>Homo_sapiens_S1PR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MGPTSVPLVKAHRSSVSDYV--------NYDIIVRHYNYTGKLNIS -------------------------------------ADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKF-HRPM YYFIGNLALSDLLAGVAYT----ANLLLSGATTYKLTPA-------QWFLREGSMF------VALSASVFSLLAIAIERY ITMLKMKLHNGSNN--FRLFLLISACWVISLILGG-LPIMG-----------WNCISA------------------LSSC STVLPLY-----HKHYILFCTTV-FTLLLLSIVILYCRIYS--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVRTRSRRLTFRK------------------------------------------------------------------- NISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLD-VGCKVKTCDILF--------------------RAEYFLV LAVLNSGTNP-------------------------IIYTLTNKEMRRAFIRIMS-----CCKCPSGD------------- ---------SAGKFKRP---IIAGMEFSRSKS-----------------------------DNSSHPQKDEGDNPETIMS ---SGNVNSSS--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Macaca_mulatta_S1PR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MGSTSVPLVKALRSSVSDYV--------NYDIIVRHYNYTGKLNTS -------------------------------------ADRENSIKLTSVVFILICCFIILENIFVLLTIWKTKKF-HRPM YYFIGNLALSDLLAGVAYT----ANLLLSGATTYKLTPA-------QWFLREGSMF------VALSASVFSLLAIAIERY ITMLKMKLHNGSNN--FRLFLLISACWVISLILGG-LPIMG-----------WNCISA------------------LPSC STVLPLY-----HKHYILFCT----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------VFIACWAPLFILLLLD-VGCKVKTCDILF--------------------RAEYFLV LAVLNSGTNP-------------------------IIYTLTNKEMRRAFIRIMS-----CCKCPSGD------------- ---------SAGKFKRP---IIAGMEFSRSKS-----------------------------DNSSHPQKDDGDNPETIMS ---SGNVNSSS--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Mus_musculus_S1PR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------MVS-TSIPEVKALRSSVSDYG--------NYDIIVRHYNYTGKLNIG -------------------------------------AEKDHGIKLTSVVFILICCFIILENIFVLLTIWKTKKF-HRPM YYFIGNLALSDLLAGVAYT----ANLLLSGATTYKLTPA-------QWFLREGSMF------VALSASVFSLLAIAIERY ITMLKMKLHNGSNS--SRSFLLISACWVISLILGG-LPIMG-----------WNCISS------------------LSSC STVLPLY-----HKHYILFCTTV-FTLLLLSIVILYCRIYS--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVRTRSRRLTFRK------------------------------------------------------------------- NISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLD-VGCKAKTCDILY--------------------KAEYFLV LAVLNSGTNP-------------------------IIYTLTNKEMRRAFIRIVS-----CCKCPNGD------------- ---------SAGKFKRP---IIPGMEFSRSKS-----------------------------DNSSHPQKDDGDNPETIMS ---SGNVNSSS--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Canis_familiaris_S1PR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MGSTSVPLVKALRSPVSDYV--------NYDIIVRHYNYTGKLNTS -------------------------------------ADKENGIKMSSVVFILICCFIILENIFVLLTIWKTKKF-HRPM YYFIGNLALSDLLAGVAYT----ANLLLSGATTYKLTPA-------QWFLREGSMF------VALSASVFSLLAIAIERY ITMLKMKLHNGSNS--FRSFLLISACWVISLVLGG-LPIMG-----------WNCIGA------------------LASC STVLPLY-----HKHYILFCTTV-FTLLLLAIVILYCRIYS--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVRTRSRRLTFRK------------------------------------------------------------------- NISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLD-VGCKVKTCDILF--------------------RAEYFLV LAVLNSGTNP-------------------------IIYTLTNKEMRRAFIRILS-----CCKCPGGD------------- ---------PAGKFKRP---IIAGVEFSRT--------SLSMVA-----------------EICLK----KSSLSTVWYP ---AGSLVSQEEQTSKTR-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Felis_catus_S1PR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MGSTSVPLVKTHRSSVSDYV--------NYDIIVRHYNYTGKLNVS -------------------------------------AD-ENGIKLSSVVFILICCFIILENIFVLLTIWKTKKF-HRPM YYFIGNLALSDLLAGVAYT----ANLLLSGATTYKLTPA-------QWFLREGSMF------VALSASVFSLLAIAIERY ITMLKMKLHNGSNS--FRSFLLISACWVISLILGG-FPIMG-----------WNCINM------------------LASC STVLPLY-----HKHYILFCTTV-FTLLLLAIVILYCRIYS--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVRTRSRRLTFRK------------------------------------------------------------------- NISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLD-VGCKVKTCDILF--------------------RAEYFLV LAVLNSGTNP-------------------------IIYTLTNKEMRRAFIRILS-----CCKCPSED------------- ---------SAGKFKRP---IIAGMEFSRSKS-----------------------------DNSSHPQKDDGDNPETIMS ---SGNVNSSS--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Pteropus_vampyrus_S1PR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MGSTSIPLVKALRSPVSDYV--------NYDIIVRHYNYTGKLNLG -------------------------------------TDKDSSIKVTSVVFILICCFIILENIFVLLTIWKTKKF-HRPM YYFIGNLALSDLLAGVAYA----VNLLFSGANTYKLTPA-------QWFLREGSMF------VALSASVFSLLAIAIERY ITMLKMKLHNESNS--SRSFLLISACWIISLILGG-LPIMG-----------WNCISM------------------LPSC STVLPLY-----HKHYILFCTTV-FTVLLLSIVILYCRIYS--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVRTRSRRLTFRK------------------------------------------------------------------- NTSKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLD-VGCKVKTCDILF--------------------KVEYFLV LAVLNSGTNP-------------------------IIYTLTNKEMRRAFIKIMS-----CCKCPRGD------------- ---------TTGKFKRP---IIAGVEFSRSKS-----------------------------DNSSHPQKDDGDNPETIMS ---SGNVNSSS--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Gallus_gallus_S1PR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MSSGTTAPVRVVSSLTNTDV--------N-YVIKEHYNYTGKLNEN -------------------------------------ADS--GIKVTSVVFIIICCFIILENIFVLLTIWKTKKF-HRPM YYFIGNLALSDLLAGVAYT----ANLLLSGHKTYSLTPS-------QWFVREGSMF------VALSASVFSLLAIAIERY ITMLKMKLHNGSNS--FRSFLLISACWVISVILGG-LPIMG-----------WNCISL------------------LSNC STVLPLY-----HKHYILFCTTV-FTGLLLSIVVLYCRIYS--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MVRTRSRRLTFRK------------------------------------------------------------------- NITKATRSSEKSLALLKTVIIVLSAFIACWAPLFILLLLD-VGCRVKTCPILY--------------------KAEYFLV LAVLNSATNP-------------------------IIYTLTNKEMRRAFIKILC-----CCKCPPTD------------- ---------SGTKFKRP---IIGGMEFSRSKS-----------------------------DNSSHPQKEEGDRPETIMS ---SGNVTSSS--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Xenopus_tropicalis_S1PR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MTPTSAT------QRRNEYY--------DHEIIIEHYNYTGKYKGN -------------------------------------LST--DIKPTSIIFIIICCFIVLENILVLLTIWRTKKF-HRPM YYFIGNLALSDLLAGTAYT----ANILLSGPHTYKLTPV-------EWLIREGSMF------VALSASVFSLVAIAIERY ITMLKMKLHNGSKS--SRSFLLISGCWILSLFLGG-LPIMG-----------WNCIKQ------------------ISAC STVLPLY-----HKHYILFCTTI-FCALLMAIVILYARIYF--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVRTRSRSLTFKR------------------------------------------------------------------- NLARPSRSSEKSMALLKTVIIVLSVFILCWSPLFIFLLLD-FGCKVKTCPVLF--------------------KAEYFLS LAVLNSATNP-------------------------IIYTLTNREMRRAFLKMAC-----CSHCSIFG------------- ---------SSSKVKRP---IITGMEFSRSKS-----------------------------DNSSHPQKDEGEYPVTLMS ---SGNVTSSS--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Danio_rerio_S1PR1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MDDLIARHYNFTGKFRKV -------------------------------------HKD-PGLKADSVVFIIVCCFIILENVLVLLTIWRTKKF-HKPM YYFIGNLALSDLLAGVVYT----ANILLSGANTYKLTPT-------QWFFREGSMF------VALAASVFSLLAIAIERH LTMLKMKLHNNGKT--CRVFMLISTVWFIAAILGG-LPVMG-----------WNCIDS------------------INNC STVLPLY-----HKAYILFCTTV-FSVILMAIVILYARIYA--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVRTRSRKLVFRKVANG-------------------------------------------------------------RG SN----KSSEKSMALLKTVIIVLSCFIACWAPLFILLLLD-VACQTLTCSILY--------------------KAEWFLA LAVLNSAMNP-------------------------LIYTLTSNEMRRAFIK-MLN----CGVCVQPS------------- -----------GKFSRP----IMGAEFSRSKS-----------------------------DNSSHPNKDEPEYSPRET- IVSSGNITSSS--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Takifugu_rubripes_S1PR1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------VGPTDQTRKRRQASVEPLY--------YSDLISKHYNYTGKFRKT -------------------------------------QQD-SGLKADSVVFIIVCCFIILENILVLTTIWRTKKF-HKPM YYFIGNLALSDLLAGVVYT----ANILLSGANTYKLTPT-------QWFFREGSMF------VALAASVFSLLAIAIERH LTMLKMKLHNNGNT--CRVFLLISAVWMVAAVLGG-LPVMG-----------WNCIQI------------------MTQC STVLPLY-----HKTYILFCTTV-FSIILMAIVVLYARIYA--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVRTRSRKLVFRKVSNG-------------------------------------------------------------RG NSGANVKSSEKSMALLKTVFIVLSCFIACWAPLFILLLLD-TACQTLSCPILY--------------------KAEWFLA LAVLNSAMNP-------------------------LIYTLTSNEMRRAFLKTLLC----CTSCLRSK------------- -----------VKFSSP----IMGAEFSRSKS-----------------------------DNSSHPNREDGEQSPRGTR TASSGTITLCS--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Tetraodon_nigroviridis_S1PR1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------DLISKHYNYTGKFRKT -------------------------------------QED-SGLKADSVVFIIVCCFIILENILVLTTIWRTKKF-HKPM YYFIGNLALSDLLAGVVYT----ANILLSGANTYKLTPT-------QWFFREGSMF------VALAASVFSLLAIAIERH LTMLKMKLHNNGNT--WRVFLLISAVWMVAAVLGG-LPVMG-----------WNCIQK------------------MSRC STVLPLY-----HKTYILFCTTV-FSIILMAIVVLYARIYT--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVRTRSRKLVFRKVSNG-------------------------------------------------------------RG NAGAAVKSSEKSLALLKTVFIVLSCFIACWAPLFVLLLLD-TACQTLSCPILY--------------------KAEWFLA LAVLNSAMNP-------------------------LIYTLTSNEMRRAFLKTLLC----CTACLRPK------------- -----------ATFTSP----IMGAEFSRSRS-----------------------------DNSSHPTREDGEHSPRGRR TASSGNVTLSS--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Gasterosteus_aculeatus_S1PR1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------SDEISSFIPVCRQKERDDAMAEPN--------YSDLIAKHYNYTGKYRKT -------------------------------------QQD-AGLKADSVVFIIVCCFIILENILVLTTIWRTKKF-HKPM YYFIGNLALSDLLAGVVYT----ANILLSGANTYKLTPT-------QWFIREGSMF------VALAASVFSLLAIAIERH LTMLQMKLHNNGNT--CRVFLLISAVWMVAAVLGG-LPVMG-----------WNCIRS------------------VTSC STVLPLY-----HKTYILFCTTV-FSIILMAIVVLYARIYA--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVRARSRRLVFRKPTNG-------------------------------------------------------------RG SAGANMKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLD-AGCETLSCPILY--------------------KAEWFLS LAVLNSAMNP-------------------------LIYTLTSNEMRRAFLKTLLC----CTACLRPK------------- -----------AKSSGP----IMGAEFSRS-S-----------------------------DK--YLKRSVLLPLPNNHR SVK----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Oryzias_latipes_S1PR1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------VVSVPIPYLRHIRLQTMAESS--------YSDLIAKHYNFTGKFRKT -------------------------------------QQD-SGLKADSVIFIIVCCFIILENILVLATIWRTKKF-HKPM YYFIGNLALSDLLAGVVYT----ANILLSGANTYKLTPT-------QWFLREGSMF------VALAASVFSLLAIAIERH LTMLKMKLHNNGNT--CRVFLLISTVWMIAAMLGG-LPLMG-----------WNCIHR------------------MSEC STVLPLY-----HKTYILFCTTV-FSIILMAIVVLYARIYT--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVRTRSSKLVFRKVTNS-------------------------------------------------------------RG NPSANTKSSEKSLALLKTVIIVLSCFIACWAPLFILLLLD-VACETLSCPILY--------------------KVDWFLA LAVLNSAMNP-------------------------LIYTLTSNEMRRAFLKTLLC----CTTCIRPK------------- -----------AKFTGP----IMGAEFSRSKS-----------------------------DNSSHPHKEEGEYSPKETT AVSSGNATSSS--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Drosophila_melanogaster_S1PR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MSAFRYFS--ITDFSFEGPLLPLHAATTSKDAKDSD------------------ -------------------------------------SPSSELNIPYTVFEVLVAIVSIIGNVLVIIV-FRRERKLRRRT NYYIVSLAMADLLVGALGI----PFAILASMGLPRNLHA--------CLFTVSLLV------VLCTISIFCLVAVSVDRY WAILYPMAY-SRNVRTRTAIFIISMCWVAGTIVGF-LPLFG----------WHADVNH------------------NQEC LFVEVMD-----YNYLVFLYFAT-IITPALLMLAFYTHIYRVIIKQVR-------------------------------- -------------------------------------------------------------------------------- -----------------------------------------QIVTMN-----------PASDLSRRSSAAVVQVTTPGRG GHTGTMLRVLG--------------------------------------------------------------------- ------AARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYVHPK----------------------LTLFCII LSHLNSAVNP-------------------------VLYAYHLKDFRAALKNLLLKMMGVDIDQQAEAIHRFSVAS----- --------QHRLQSMDSNMRSTQPRLYVGEYSPIWLRQQQEALKNSQLLPKCGVVSPCFNNINQTVAAVASVTTDLEREM WNIVEASSGAELGETSYEFPSPAPGSQRSSERNSSSTVPPAPPAPAKPSVPSASYDNHNYSFSQDEDEDDDDLEFEDVFV PASSVPNPVQPGIDPVELRRSLALVMREKLRSDDTDSRPMGNNQDLPIDEQSRERPLSTQTSPTNGPLPALLRAKLLAGN SNSAHCLPGSTASPAPQEQSGIFVIDSEASPGSNGHKPKYRKGTAFTRSSLKKSRSCNCSSIAKGRGVHDEPSSNLCRDQ ESSVLPQHPQPANHPTENFFSPLRSVGSFMQHSNLFHFLQPHAARPTSSTASSTASTPTPSPPPMGQAQEESVPVGLTTS SPSLLATSAES--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Apis_mellifera_S1PR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MEFPSNISELANNLTVTALNASTHS------------------------- -----------------------------------------ELNLPYTVCEILVAVCAVFGNGLVIIV-FSKEKKLRRRT NYYIISLATADLLVGLFAI----PFAILASIGLPKNLHA--------CLFTVSVLI------VLCTISIFCLVAVSVDRY WAILHPMGY-SRTVRTKTAIGIICVCWIAGTLVGF-LPLLG----------WNAGKKS------------------NEKC IFTEVMD-----YDYLVFLYFAT-IIFPALLIAAFYAHIYRVVVKQLQ-------------------------------- -------------------------------------------------------------------------------- -----------------------------------------QIVTMN---------------PGRRTG-----------N QTTGTMLRLLG--------------------------------------------------------------------- ------AARKREVKATQNLSRIVIFFIICWIPLYTINCVMAFCPWCRVNDV----------------------VMNFCII LSHLNSAGNP-------------------------LLYAYHLKDFRAALKNFMWNLLFPHNN------------------ -------------------MKSSVVSVIHERGSLVDSQRQYHRQIGGLSSSKRPTSSLLRQVTDVRSKGLSVSRDIS--- --------------------------IRDKETGNASSSSQS-----------------------DKQEDDNMSQNSNEFQ RNES-----------------------DKFENNRIDSNISKSSSHITSMELQTYKPLMP--------------------- -----LLPAEIDNVEETPPASIFVIEVDVNHMESVHKKVNEELTENKDKG------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Homo_sapiens_S1PR2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------MGSLYSEYL--------NPNKVQEHYNYTKETLET --------------------------------------QETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKF-HSAM YLFLGNLAASDLLAGVAFV----ANTLLSGSVTLRLTPV-------QWFAREGSAF------ITLSASVFSLLAIAIERH VAIAKVKLYGSDKS--CRMLLLIGASWLISLVLGG-LPILG-----------WNCLGH------------------LEAC STVLPLY-----AKHYVLCVVTI-FSIILLAIVALYVRIYC--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- VVRSSHADMA---------------------------------------------------------------------- --APQT------LALLKTVTIVLGVFIVCWLPAFSILLLD-YACPVHSCPILY--------------------KAHYFFA VSTLNSLLNP-------------------------VIYTWRSRDLRREVLRPLQCWRPGVGVQGRRR------------- -------------GGTPG----HHLLPLRS-------------------------------SSSLERG---MHMPTSP-T FLEGNTVV------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Pan_troglodytes_S1PR2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------MGSLYSEYL--------NPNKVQEHYNYTKETLET --------------------------------------QETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKF-HSAM YLFLGNLAASDLLAGVAFV----ANTLLSGSVTLRLTPV-------QWFAREGSAF------ITLSASVFSLLAIAIERH VAIAKVKLYGSDKS--CRMLLLIGASWLISLVLGG-LPILG-----------WNCLGH------------------LEAC STVLPLY-----AKHYVLCVVTI-FSIILLAIVALYVRIYC--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- VVRSSHADVA---------------------------------------------------------------------- --APQT------LALLKTVTIVLGVFIVCWLPAFSILLLD-YACPVHSCPILY--------------------KAHYFFA FSTLNSLLNP-------------------------VIYTWRSRDLRREVLRPLQCCRPGVGVQGRRR------------- -------------GGTPG----HHLLPLRS-------------------------------SSSLERG---MHMPTSP-T FLEGNTVV------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Macaca_mulatta_S1PR2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------MGSLYSEYL--------NPNKVQEHYNYTKETLET --------------------------------------QETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKF-HSAM YLFLGNLAASDLLAGVAFV----ANTLLSGSVTLRLTPV-------QWFAREGSAF------ITLSASVFSLLAIAIERH VAIAKVKLYGSDKS--CRMLLLIGASWLISLVLGG-LPILG-----------WNCLGH------------------LEAC STVLPLY-----AKHYVLCVVTI-FSIILLAIVALYVRIYC--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- VVRSSHADVA---------------------------------------------------------------------- --GPQT------LALLKTVTIVLGVFIVCWLPAFSILLLD-YACPVHSCPILY--------------------KAHYFFA FATLNSLLNP-------------------------VIYTWRSRDLRREVLRPLQCWRPGVGVQGRRR------------- -------------DGTPG----HHLLPLRS-------------------------------SSSLERG---MHMPTSP-T FLEGNTVV------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Mus_musculus_S1PR2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------MGGLYSEYL--------NPEKVLEHYNYTKETLDM --------------------------------------QETTSRKVASAFIIILCCAIVVENLLVLIAVARNSKF-HSAM YLFLGNLAASDLLAGVAFV----ANTLLSGHVTLSLTPV-------QWFAREGSAF------ITLSASVFSLLAIAIERQ VALAKVKLYGSDKS--CRMLMLIGASWLISLILGG-LPILG-----------WNCLNQ------------------LEAC STVLPLY-----AKHYVLCVVTI-FSVILLAIVALYVRIYF--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- VVRSSHADVA---------------------------------------------------------------------- --GPQT------LALLKTVTIVLGVFIICWLPAFSILLLD-STCPVRACPVLY--------------------KAHYFFA FATLNSLLNP-------------------------VIYTWRSRDLRREVLRPLQCWRRGKGVTGRR-------------- -------------GGNPG----HRLLPLRS-------------------------------SSSLERG---MHMPTSP-T FLEGNTVV------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Canis_familiaris_S1PR2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------MGNLYSEYL--------SPNKVREHYNYTKETLDT --------------------------------------QETASRQAALVIIIILCFAIVVENLLVLIAVARNSKF-HSAM YLFLGNLAASDMLTGVAFV----ANTLLSGPVTLGLTPI-------QWFAREGSAF------ITLSASVFSLLAIAIERH VAIAKVKLYGSDKS--CRMLLLIGASWLISVALGG-LPILG-----------WNCLGH------------------LEAC STVLPLY-----TKHYVLCVVTI-FSVILLAIVALYVRIYC--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- VVRSSQADVA---------------------------------------------------------------------- --GPQT------LALLKTVTIVLGVFIVCWLPAFSILLLD-YACPVRSCPILY--------------------KAHYFFA FATLNSLLNP-------------------------VIYTWRSRDLRREAQR-----------FGKR-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Felis_catus_S1PR2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------MGSLYSEYL--------SPSKVLEHYNYTKETLDT --------------------------------------QETTSRWVALVIIVLICFTIVVENLMVLIAVARNSKF-HSAM YLFLGNLAASDLLTGVAFV----ANTLLSGPVTLGLTPL-------EWFAREGSAF------ITLSASVFSLLAIAIERH VAIAKVKLYGSDKS--CRMLLLIVASWLISLVLGG-LPILG-----------WNCLGH------------------LEAC STVLPLY-----TKHYVLCVVTI-FSVILLAIVALYIRIYC--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- VVRSSHVDVT---------------------------------------------------------------------- --GPQT------LALLKTVTIVLGVFIVCWLPAFSILLLD-YACPVRSCPVLY--------------------KAHYFFA FATLNSLLNP-------------------------VIYTWRSRDLRREVLRPLQCCRRAAGVQGRR-------------- -------------GGTPG----HRLLPLRS-------------------------------SSSLERG---THMPTSP-T FLEGNTMV------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Pteropus_vampyrus_S1PR2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------MGSLYSEYL--------SPTKVQEHYNYTKETLDT --------------------------------------QETPSRKVASALIIILCCAIVVENLLVLIAVARNSKF-HSAM YLFLGNLAASDLLAGVAFI----ANTLLSGSVTLRLTPV-------QWFAREGSAF------ITLSASVFSLLAIAIERH VAIAKVKLYGSDKS--CRMLLLIAASWLISLALGG-LPILG-----------WNCLGH------------------LEAC STVLPLY-----AKHYVLCVVTI-FSAILLAIVVLYIRIYC--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- VVRSSHADVA---------------------------------------------------------------------- --GPQT------LALLKTVTIVLGVFIVCWLPAFSILLLD-YACPVHSCPILY--------------------KAHYFFA FATLNSLLNP-------------------------VIYTWCSRDLRREVLRPLQCWRQAAGVQGRR-------------- -------------SGTPG----HHLLPLRS-------------------------------SSSLERG---THMPTSP-T ILEGNTVV------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Danio_rerio_S1PR2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------MTTCRLFAGFCQAVTMSKYSQYF--------NKTLIQVHYLTAKEMTAE ELRD--------------------------------RIESKQSLSSLNILFVVICSIIILENLLVLIAVFRNKKF-HSAM FFFIGNLAFSDLLAGSAYI----ANIFLSGPRTFHLTPV-------QWFIREGTAF------IALSASVFSLLAIAIERY IAITKVKVYGSNKT--CRMFLLIGACWVMSILLGG-LPIIG-----------WNCINN------------------LDDC SAVLPLN-----TRYYIRFVVTI-FSIILLSIVILYVRIYL--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- IVRTSHQEAT---------------------------------------------------------------------- --NSPA------YALLKTVTIVLGVFIICWLPAFTILLLD-TSCKMKQCPILN--------------------NAGIFFS FATLNSALNP-------------------------LIYTLRSKDMRKEFLRVLCCWG-------LLNC------------ -------------GRPPH----RCMVPLKS-------------------------------SSSMEHCTNKHEHQSIP-I MQDCTTCV------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Tetraodon_nigroviridis_S1PR2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------MKSKYSQYY--------NKSLIQCYYIFAKNLTPQ DLSK--------------------------------RNDNKNQLPTLNIVIVVLCTIIILENLLVLIAVCRNKKF-HSAM FFFIGNLAFSDLLTGSAYI----ANIFLSGSRTFELMPI-------QWFIREGTAF------IALAASVFSLLAIAVERY LAITKVKVYGATKT--CRMFLLIGASWVTSILLGG-LPILG-----------WNCINN------------------LPEC SAVLPLY-----SKKYILFVVTI-FSIILLSIVILYVKIYL--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- IVRSSRQEAT---------------------------------------------------------------------- --NSAT------YSLLKTVTIVLGVFILFWLPAFTILLLD-SFCNIQFCSILS--------------------EAQMFFG FATLNSALNP-------------------------VIYTLRSKDMRKEFLRVLCCWG-------VLQS------------ -------------GRPSD----RCLVPLKS-------------------------------SSSLEHCTHKHEHQTMP-I MQDCTTCV------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Gasterosteus_aculeatus_S1PR2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------LGSVRVPS--FTYSMKSKYSQYY--------NQSLIHSYYTFAKNMSTQ ELAK--------------------------------RIENKKKLSSLDMVIVVLCTIIILENLLVLIAVCRNKKF-HSAM FFFIGNLAFSDLLAGSAYI----ANIFLSGSRTFDLMPV-------QWFIREGTAF------IALAASVFSLLAIATERY IAITKVKVYGSTKT--CRMFLLIGACWVTSILLGG-LPIMG-----------WNCIND------------------LPEC SAVLPLY-----SKKYILFVVTI-FSLILLSIVILYVRIYL--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- IVRSSHQEAT---------------------------------------------------------------------- --NLPA------YALLKTVTIVLGVFIMCWLPAFTILLLD-TSCRIQFCPILS--------------------KAEFFFS FATLNSALNP-------------------------VIYTLRSKDMRKEFLRVLCC------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Oryzias_latipes_S1PR2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------VGRTSYPPAVFCPFHKSKYSQYY--------NTNLIRLHYAHAKNMSKA EIHE--------------------------------RESEKDHPDLLSIIILVICTIIIFENLLVLMAVWRNKKF-HSAM FFFIGNLAFSDLLAGCAYI----VNIILSGPRTYSLCPV-------QWFIREGTAF------IALAASVFSLLAIAIERY VAITKVKVYGSNKS--CRMFLLIGACWVTSILLGG-LPILG-----------WNCIFD------------------LGDC STVLPLY-----SKKYIVFVVTV-FSLILLSILILYVRIYL--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- IVRSSNQVTT---------------------------------------------------------------------- --NMQA------YSLLKTVTIVLGVFIVCWLPAFTILLLD-SSCSIQVCTILD--------------------KAKIFFG FATLNSALNP-------------------------VIYTLRSKDMRREFLRVLCC------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Hydra_magnipapillata_S1PR2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MIVVHIHKIINTSSEIKKEEESKG------------------------------ ----------------------------------------------------------------------RNTSKLNVYS -----VIAFCEIGCDYN---------------IINRNAV---------YFFITTDV------LFGITSILSLTAISLERM FAVKFPTRH--FNLSSALVFIVIAFTWFIGIVFSV-AQFFI--------------------------------------- --SFQNV-----RWYIAFLLVFA-YIFPLFIIVVSYCIIYCAIR-MMR-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----DNSNQD---------------------------------------------------------------------- ------GKTKQELRVAKIISIIIGLFFICWSPFFILNTVHLFCKEVYCRKLPIW-------------------LINITKM LHYSHSMMNF-------------------------FVYGYRSPDFRHIFR-AFLKCRLSLMQGRVRSLSESINLE----- --------QSSS-----FKRERNIENSEEVLVT---LASDEI-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Homo_sapiens_S1PR3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MATALPPRLQPVRGN------------ETLREHYQYVGKLAGR LK-----------------------------------EASEG-STLTTVLFLVICSFIVLENLMVLIAIWKNNKF-HNRM YFFIGNLALCDLLAGIAYK----VNILMSGKKTFSLSPT-------VWFLREGSMF------VALGASTCSLLAIAIERH LTMIKMRPYDANKR--HRVFLLIGMCWLIAFTLGA-LPILG-----------WNCLHN------------------LPDC STILPLY-----SKKYIAFCISI-FTAILVTIVILYARIYF--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVKSSSRKVA---------------------------------------------------------------------- ----NHNNSERSMALLRTVVIVVSVFIACWSPLFILFLID-VACRVQACPILF--------------------KAQWFIV LAVLNSAMNP-------------------------VIYTLASKEMRRAFFRLVCN----CLVRGRGA------------- -------------RASP---IQPALDPSRSK-----------------------------SSSSNNSS-HSPKVKEDLPH TAPSSCIMDKNA-ALQNGIFCN---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Pan_troglodytes_S1PR3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MATALPPRLQPVRGN------------ETLREHYQYVGKLAGR LK-----------------------------------EASEG-STLTTVLFLVICSFIVLENLMVLIAIWKNNKF-HNRM YFFIGNLALCDLLAGIAYK----VNILMSGKKTFSLSPT-------VWFLREGSMF------VALGASTCSLLAIAIERH LTMIKMRPYDANKR--HRVFLLIGMCWLIAFTLGA-LPILG-----------WNCLHN------------------LPDC STILPLY-----SKKYIAFCISI-FTAILVTIVILYARIYF--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVKSSSRKVA---------------------------------------------------------------------- ----NHNNSERSMALLRTVVIVVSVFIACWSPLFILFLID-VACRVQACPVLF--------------------KAQWFIV LAVLNSAMNP-------------------------VIYTLASKEMRRAFFRLVCN----CLVRGRGA------------- -------------RASP---IQPALDPSRSK-----------------------------SSSSNNSS-HSPKVKEDLPH TAPSSCIMDKNA-ALQNGIFCN---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Macaca_mulatta_S1PR3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------XREHYQYVGKLAGR LM-----------------------------------EASEA-GTLTTVLFLVICSFIVLENLMVLIAIWKNNKF-HNRM YFFIGNLALCDLLAGIAYK----VNILMSGKKTFSLSPT-------VWFLREGSMF------VALGASTCSLLAIAIERH LTMIKMRPYDANKK--HRVFLLIGMCWLIAFTLGA-LPILG-----------WNCLHN------------------LPDC STILPLY-----SKKYIAFCISI-FTAILVTIVILYARIYF--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVKSSSRKVA---------------------------------------------------------------------- ----NHNNSERSMALLRTVVIVVSVFIACWSPLFILFLID-VACRVQACPVLF--------------------KAQWFIV LAVLNSAMNP-------------------------VIYTLASKEMRRAFFRLVCN----CLVRGRGA------------- -------------RASP---IQPALDPSRSK-----------------------------SSSSNNST-HSPKVKEDLPH TAPSSCIMDKNA-ALQNGIFCK---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Mus_musculus_S1PR3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MATTHAQGHQPVLGN------------DTLREHYDYVGKLAGR LR-----------------------------------DPPEGGTLITTILFLVTCSFIVLENLMVLIAIWKNNKF-HNRM YFFIGNLALCDLLAGIAYK----VNILMSGRKTFSLSPT-------VWFLREGSMF------VALGASTCSLLAIAIERH LTMIKMRPYDANKK--HRVFLLIGMCWLIAFSLGA-LPILG-----------WNCLEN------------------FPDC STILPLY-----SKKYIAFLISI-FTAILVTIVILYARIYC--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVKSSSRRVA---------------------------------------------------------------------- ----NHN-SERSMALLRTVVIVVSVFIACWSPLFILFLID-VACRAKECSILF--------------------KSQWFIM LAVLNSAMNP-------------------------VIYTLASKEMRRAFFRLVCG----CLVKGKGT------------- -------------QASP---MQPALDPSRSK-----------------------------SSSSNNSS-HSPKVKEDLPR VATSSCIIDKNR-SFQNGVLCK---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Canis_familiaris_S1PR3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------MCLRRPLLGSGAEPLRARAMATVVPPRARPSPGNGN--------ETETLHEHYNYVGKLEGR LR-----------------------------------EAPEG-SMPTTVLFLIICSFIVLENLMVLIAIWKNNKF-HNRM YFFIGNLALCDLLAGIAYK----VNILMSGKRTLSLSPT-------LWFLREGSMF------VALGASTCSLLAIAIERH LTMIKMRPYDANKK--HRVFLLIGMCWLIAFSLGA-LPILG-----------WNCLHN------------------LPDC STILPLY-----SKRYIAFCISI-FTAILVTIVILYARIYF--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVKSSSRRVA---------------------------------------------------------------------- ----SPHNSERSMALLRTVVIVVSVFIACWSPLFILFLVD-VACRVKQCAILF--------------------KAQWFIV LAVMNSAMNP-------------------------VIYTLASKEMRRAFFRLVCT----CLVRRWGA------------- -------------RSSP---TQPALDPSRSK-----------------------------SSGSNNSS-PSPKSKEDPPQ IAASPCIMDGNK-TLQNGILCK---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Felis_catus_S1PR3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------QHYNYVGKLEGR LK-----------------------------------EAPEG-STLTTVLFLVICSFIVLENLMVLIAIWRNNKF-HNRM YFFIGNLALCDLLAGIAYK----VNILMSGKRTLSLSPT-------VWFLREGSMF------VALGASTCSLLAIAIERH LTMIKMRPYDANKK--HRVFLLIGMCWLIALSLGA-LPILG-----------WNCVHD------------------LPDC STILPLY-----SKKYIAFCISI-FTAILVTIVILYARIYF--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVKSSSRRVA---------------------------------------------------------------------- ----SPHNSERSMALLRTVVIVVSVFIACWSPLFILFLVD-VACRVKECAVLF--------------------KAQWFIM LAVLNSAMNP-------------------------VIYTLASKEMRRAFFRLVCT----CLVRGRGA------------- -------------RSSP---TQPALDPSRSK-----------------------------SSGSNNSS-PSPKSKEDPPQ RVASPCITDGNK-------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Myotis_lucifugus_S1PR3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------LYEHYNYVGKLAGR LT-----------------------------------DAPEG-SALTTVLFLVICSFIVLENLMVLIAIWKNKKL-HNRM YFFISNLALCDLLAGIAYK----VNILMSGKRTLSLSPT-------VWFLREGSMF------VALGASTCSLLAIAIERH LTMIKMRPYNANKK--HRVFLLIGMCWLIALSLGA-LPILG-----------WNCLQN------------------LPDC STILPLY-----SKKYIAFCISI-FTAILVAIVILYARIYC--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVKSSSRRVA---------------------------------------------------------------------- ----NPQHSERSMALLRTVVIVVSVFIACWSPLFILFLVD-VACKVKECAVLF--------------------KDKWFIV LAVLNSAMNP-------------------------VIYTLASKEMRRAFFRLVCN----CLVRAQGT------------- -------------RSLP---IQLTLDPSKSK-----------------------------SSGS-NSS-PSPKSKEDITQ TAPSPCITDRNK-------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------- >Xenopus_tropicalis_S1PR3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------NMASGSLPSKKLEP----RR--------CDEVINRHYNYTGKLKER -------------------------------------E--LDHMDMTEIVFLIICSLIVLENLMVLIAIWKNNRF-HNRM YFFIGNLALCDMLAGIAYI----VNICMSGSKTMDISLT-------AWFVREGSMF------IALGASTFSLLAIAIERH LTMIKMRPYDANKK--YRVFLLIGTCWLISFSLGA-LPILG-----------WNCIED------------------LPNC STILPLY-----SKRYVGFCISI-FIAILIAIVILYARIYI--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- LVKSSSRRVT---------------------------------------------------------------------- ----NHSNSERSMALLRTVVIVVGVFIACWSPLFILLLID-VACEVKTCSILY--------------------KAQWFIA LAVLNSALNP-------------------------VIYTLASKEMRRAFFRLVCS----CLVKTNNS------------- -------------RSLP---IQPTPDQSRSK----------------------------