>Homo_sapiens_RFX1 ---------------------MATQAYT-ELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTEL QSPQPQAQPPGGQKQYVTELPAVPA-PSQPTGAPTPSPA-------------PQQYIVVTVSEGAMRASETVSEASPGST AS---------QTGVPTQVVQQVQGTQQ---RLLVQTSVQAKPGHVSPLQLTNIQVPQQALP---TQRLVVQSAAPGSKG G---QVSLTVHGTQQ--VHSPPEQSPVQAN----SSSSKTAGAPTGTVPQQLQVHGVQQSVPVTQERSVVQATPQAPKPG PVQPLTVQGLQP-VHVAQEVQQLQQVPVPHVYSSQVQYVEG-GD------ASYTASAIRSSTYSYP-------------E TPLYTQT---ASTS---YYEAA----GTATQVSTPATSQAVASS-----GSMPMY----VSGSQVVASSTSTGAGASNSS GGGGSGGGGGGGGGGGGGG----SGSTGGGGSGAGTYVIQGGY--MLGSA--------SQSYSHTTRASP-AT------- VQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGLRIKASSPL L-------------------------------RLMEDQQH----------------------------------MAMRGQ PFSQKQRLKPIQKMEG-MTNGVAVGQQP-------STGLSDISAQVQQYQQFL------DASRSLPDFTELDLQG--KVL PEGVGP--GDIKAFQVLYREHCEAIVDVMVN----LQFTLVETLWKTFWR--YNLSQPSEAPPLAVHD--------EAEK RLPKAILVLLSK----FEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSA---LTQA-IRNFAKSLESWLTHAMV--NIP EEMLRVKVAAAGAFAQTLRRYTSLNHLAQ-AARAVLQNTAQ-INQMLSDLNRVDFANVQEQAS----WVCRCEDRVVQRL EQ-----------------------DFKVTLQQQN--SLEQWAAWLDGVVS--QVLKPYQG-SAG-FPKAAKLFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMYYLIEHRVAQAKGETPIAVMGEF--------------------ANL ATSLNPLDPDKDEEEE-------------EEEESEDELPQDISLAAGGESP-ALGPE----------------------- -----------TLEPPAKLARTDARGLFVQALPSS--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Pan_troglodytes_RFX1 ---------------------MATQAYT-ELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTEL QSPQPQAQPPGGQKQYVTELPAVPA-PSQPTGAPTPSPA-------------PQQYIVVTVSEGAMRASETVSEASPGST AS---------QTGVPTQVVQQVQGTQQ---RLLVQTSVQAKPGHVSPLQLTNIQVPQQALP---TQRLVVQSAAPGSKG G---QVSLTVHGTQQ--VHSPPEQSPVQAN----SSSSKTAGAPTGTVPQQLQVHGVQQSVPVTQERSVVQATPQAPKPG PVQPLTVQGLQP-VHVAQEVQQLQQVPVPHVYSSQVQYVEG-GD------ASYTASAIRSSTYSYP-------------E TPLYTQT---ASTS---YYEAA----GTAAQVSTPATSQAVASS-----GSMPMY----VSGSQVVASSTSTGAGASNSS GGGGSGGGGGGGGGGGGGG----SGSTGGGGSGAGTYVIQGGY--MLGSA--------SQSYSHTTRASP-AT------- VQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGLRIKASSPL L-------------------------------RLMEDQQH----------------------------------MAMRGQ PFSQKQRLKPIQKMEG-MTNGVAVGQQP-------STGLSDISAQVQQYQQFL------DASRSLPDFTELDLQG--KVL PEGVGP--GDIKAFQVLYREHCEAIVDVMVN----LQFTLVETLWKTFWR--YNLSQPSEAPPLAVHD--------EAEK RLPKAILVLLSK----FEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSA---LTQA-IRNFAKSLESWLTHAMV--NIP EEMLRVKVAAAGAFAQTLRRYTSLNHLAQ-AARAVLQNTAQ-INQMLSDLNRVDFANVQEQAS----WVCRCEDRVVQRL EQ-----------------------DFKVTLQQQN--SLEQWAAWLDGVVS--QVLKPYQG-SAG-FPKAAKLFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMYYLIEHRVAQAKGETPIAVMGEF--------------------ANL ATSLNPLDPDKDEEEE-------------EEEESEDELPQDISLAAGGESP-ALGPE----------------------- -----------TLEPPAKLARTDARGLFVQALPSS--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Macaca_mulatta_RFX1 ---------------------MATQAYT-ELQAAPPPSQPPQAPPQAQPQPPPPPPPAAPQPPQPPTAAATPQPQYVTEL QSPQPQAQPPGSQKQYVTELPAVPA-PSQPTGAPTPSPA-------------PQQYIVVTVSEGAMRASETVSEASPGST AS---------QTGVPTQVVQQVQGTQQ---RLLVQTSVQAKPGHVSPLQLTNIQVPQQALP---TQRLVVQSAAPGSKG G---QVSLTVHGTQQ--VHSPPEQSPVQAN----SSSSKTAGAPTGTVPQQLQVHGVQQSVPVTQERSVVQATPQAPKAG PVQPLTVQGLQP-VHVAQEVSWFPRVPAPSLVASLLSLLCL-GA------AASPVPSCRSSTYPYP-------------E TPLYTQT---ASTS---YYEAA----GTAAQVSTPATSQAVASS-----GSMPMY----VSGSQVVASSTSTGAGASNSS GGGGSGGGGGGGGGGGGGG----SGSTGGGGSGAGTYVIQGGY--MLGSA--------SQSYSHTTRASP-AT------- VQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGLRIKASSPL L-------------------------------RLMEDQQH----------------------------------MAMRGQ PFSQKQRLKPIQKMEG-MTNGVAVGQQP-------STGLSDISAQVQQYQQFL------DASRSLPDFTELDLQG--KVL PEGVGP--GDIKAFQVLYREHCEAIVDVMVN----LQFTLVETLWKTFWR--YNLSQPSEAPPLAVHD--------EAEK RLPKAILVLLSK----FEPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSA---LTQA-IRNFAKSLESWLTHAMV--NIP EEMLRVKV------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Mus_musculus_RFX1 ---------------------MATQSYVTELQAAPQASQPPQAPPQALPQP---PPPAAPQPP----AAATPQPQYVTEL QSPQPQTQPPGSQKQYVAELPAAPA-PSQPA-TPAPSPV-------------AQQYIVVTVSEGAMRASETVSEASPSST AS---------QTGVPTQVVQQVQGTQQ---RLLVQASVQAKPGHVSPLQLTNIQVPQQAIP---TQHLVVQSPAPGTKS G---QVSLTVHSAQQ--VHSAPERSPVQAN----NSTSKTAGTPAATV-QQLQVHSVQQSVPVTQERSVVQATPQT-KAG PVQQLTVQGLQP-VHVAQEVQQLPQVPVPHVYSSQVQYVEG-GD------ASYTASAIRSSTYQYP-------------E TPIYTQT---AGTS---YYEAS----GTAAQVSTPATSQTVASS-----GSVPMY----VSGSPIVASSSSSEAGASNSS VG--AGGNGGGGSSGGGSG-------GSSG-SGAGTYVIQGGY--MLGNA--------SQSYSHTTRASP-AT------- VQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGLRIKASSPL L-------------------------------RLMEDQQH----------------------------------MAMRGQ PFSQKQRLKPIQKMEG-VANGVAVGQQ--------STGLSDISAQVQQYQQFL------DASRSLPDFAELDLQG--KVL PEGVGP--GDIKAFQVLYREHCEAIVDVMVN----LQFTLVETLWKTFWR--YNLSQPSEAPPLAVHD--------EAEK RLPRASLVLLSK----FQPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSA---LTQA-IRNFAKSLESWLTHAMV--NIP EEMLRVKVAAAGAFAQTLRRYTSLNHLAQ-AARAVLQNTAQ-INQMLSDLNRVDFANVQEQAS----WVCRCEDRVVQRL EQ-----------------------DFKVTLQQQN--SLEQWAAWLDGVVS--QVLKPYQG-SSG-FPKAAKLFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMYYLIEHRVAQAKGETPIAVMGEF--------------------ANL ATSLNPLDPDKDEEEE-------------EEEESEDELPQDISLAAGSESP-ALGPE----------------------- -----------ALEPPAKLARTDTRGLFVQALPSS--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Monodelphis_domestica_RFX1 -------------------------------------------------------------------------------- -------------------------------------------------------------TEGAMRASDTVSEASPGST AS---------QSGVPTQVVQQVQATPQQ--RLLVQASVQAKPGAVSPLQLTSIQVPQQAFL---MQRLVVQSSAQASKG G---PASLTVHSVQQ--AHSPPERSPGQGN----SSTSKAG------SVQQLQVHSVQA-VPAPQERSVVQTAPQTSKSG SVQQLTVQGLQP-VHVTQEVQQLQQVPVQHVYPGQVQYVEG-GD------ASYTASTIRSGTYPYT-------------E TPLYTQN---AGTS---YYESQ----GTTAQVSTPATSQAVASS-----GSVPMY----VSGGQIVTNSSGSSSGGGGGG GAG--------------------------------TYVIQGGY--MLGSS--------SQSYSHTTRASP-AT------- VQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGLRIKANSPL L-------------------------------RLMEDQQH----------------------------------MAMRGQ PFSQKQRLKPIQKMEG-MTNGVAVGQQQ-------AAGLSDISAQVQQYQQFL------DASRSLPEFTELDLQG--KVL PEGIGP--EDIKAFQVLYREHCEAIVDVMIN----LQFTLVETLWKTFWR--YNLNQPSEATPLAVHD--------EAEK RLPKSSLVLLSK----YEPVLKWTKDCDNLLYQGLVEILIPDVLRPIPSA---LTQA-IRNFAKSLESWLTNAMM--NIP EEMVRVKVAAASAFAQTLRRYTSLNHLAQ-AARAVLQNTAQ-INQMLSDLNRVDFANVQEQAS----WVCRCEDRVVQRL EQ-----------------------DFKVTLQQQN--SLEQWAGWLDGVVS--QVLKPYQG-SAS-FPKAAKLFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMYYLIEHRVAQAKGETPIAVMGEF--------------------ANL ASSLNPLDPDKDEEEE-------------EEEESEDELPQEISLNSSESTA-LSSES----------------------- -----------LEPP-AKLARTEGRGIFVQALPSS--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Anolis_carolinensis_RFX1 ---------------------MATQAYVTELQAAQQ-------QSQQQQQSQQQPAATAATAAPVVVAAAAAQQQYVAEL QGAQ---QQQPTPKQYVPEIPPPQT-QAPPTGQQTSTPA-------------PQQYIVVTVSEGSMRPSDTVSESSPGST AT---------QSGVPTQVVQQVQAT-QQ--RLLVQASVQTKPGTVSPLQLTSVQVPQQVIL---FQRLVVQSTSQASKG G---PVALAVHGVQQ--VHSSPEHSPVQNS----SSAAKPG------QVQQLQLHGVQQ-VPVAQERSVVQTTPSAPKAG SVQQLAVQGLQQ-VHVTQEVQQLQQVPVQHVYPNQVQYVEG-GD------ASYTASTIRSNTYSYT-------------E TPLYTQN---AGAN---YYESQ----GTSTQVSSPATSQTVASS-----GSVPMY----VSGGQIIANPSGGSSAGGGGG GSGGGGGGGGGAGNGGSSTPGGGGGSGSGSSSSTGTYVIQGGY--MLGSS--------SQSYSHTTRASP-AT------- VQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGLRIKANSPL L-------------------------------RLMEDQQH----------------------------------LAMRQQ PFSQKQRLKSIQKMEG-MTNGVAVGQQQ-------ASGLSDISAQVQQYQQFL------DASRSLPDFAEIDLQG--KTL PEGIVP--EDVKAFQLLYREHCEAIVDVMVN----LQFTLVETLWKTFWR--YNMNQPSEATSIVIHD--------EAEK RLPKSCLVTLSK----YEPVLKWTKDCDNLLYQGLVEVLIPEVLRPIPSA---LTQA-IRNFAKSLESWLTNAMM--NIP EEMVRVKVAAASAFAQTLRRYTSLNHLAQ-AARAVLQNTAQ-INQMLSDLNRVDFANVQEQAS----WVCRCEDRVVQRL EQ-----------------------DFKMTLQQQN--SLEQWAVWLDGVVS--QVLKPYHG-SPS-FPKAAKLFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMYYLIEHRVAQAKGETPIAVMGEF--------------------ANL TSSLNPLDPDKDEEEE-------------EEEESDEEMPQELSLSSNESSS-LTADP----------------------- -----------MEPPPSKLARTDARGIFVQALPSS--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Xenopus_tropicalis_RFX1 ---------------------------------------------------------------------------YVTEL QAAAP-AATQGTPQQYVAELQVTPSGSSQASGAQTPS---------------AQQYIVVTVSEGSVRGSD--GELSPGGT PTP--------TTGVPTQVVQQVQAAQQ---RLLVQARVQPKVTAVSPLQLAGSSVPQQILLSILCQRLVVQSSPQGTKA A---QVSLTVHTVQQQPAHSPPDVSTIYTVGSLGDSSLGDSPSLKAGQAQPLQLHGTQQ------ERSVVQANPQK--SS PVHQLTVQALQH-VQGAAEVQQLQQVPVQHVYPSQVQYVEG-TD------ATYTGSTIRSGSYPYT-------------E TPLYTQA---TGST---YYEAQ----GATGQVSSPTSSPALASS-----PSVPMY----VSGGQILTNTTQSAASGGTGG GG---------------------------SGSGTGTYVIQGGF--IMGSS--------TQSYSHTTRASP-AT------- VQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGLRIKASSPL L-------------------------------RLMEDQQH----------------------------------LAMRQQ PFSQKQRLKTVQKMEG-MSNGVGGSQQQ-------ASGLSDISAQVQQYQQFL------DASKTLPEFAEMDLQG--KPL PDGVTL--ANVKAFQLLYREHCEAIVDVVVN----LQFTLVETLWKTFWR--FNQTQHSDSTILSRDD--------EAEK RLPKDCLVLLSK----YEPLLKWSRDCDHLLYQVLVETLIPDVLRPIPSA---LTQA-IRNFAKSLESWLTSAMM--NIP EEMVRVKASAASAFAQTLRRYTSLNHLAQ-AARAVLQNTAQ-INQMLSDLNRVDFTNVQEQAS----WVCRCADRVVQRL EQ-----------------------DFKLTLQQQS--SLEQWAEWLDSVVS--QVLKPYQG-SPG-FPKAAKLFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMYYLIEHRVAQARGETPIAVMGEV--------------------SAT IRAGRDRETEEEEEEE---------------DESDEDLTHDLPLTMSDPSG-ALGSD----------------------- -----------SLEPPAKLARSDSQAIFVQVPPTS--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Danio_rerio_RFX1_b ---------------------MATPAYVRELQQTSQPQGG--SVTPTSGQASTVTAGPQQFLAELQTTGATPSAAPPTGR TTPP-----TSQAQKSQAIAQAPPT-QAPPTQTQYVTAEIQSSPTQSSNAQNTPQYIVVTVTEGSLHSSDSVSDSSPPAA VV---------QTGVPTQVVQQVQSAQQ---------------------------------------RSVVQATSQTTKT E--PGTQLNVTSLQS--VHLT----------------------------------------------------------- ----------------QEVQQQLQQVPVQHVYTNQVQYVEG-GE------ANYTTSTIRSSSFPYT-------------E TPLYTQS---SAGQ---YYEATP---ASGSEAASPGTPLTVSVT-----SGSPGVPMFVAGTGQIVANPTTAAGSGVTAV VAAAGTAANGSGESAGEAN------------GSGGSYVIQGGY--MLAGT-GSGSSGNGHGYPHPTRASPATLSSGP--Q VQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGLRIKASSSL L-------------------------------RLMEDQQH----------------------------------LAMRQQ PFSQKQRLKPVQKVEG-ITNGMSSGSGQQQQQ-QQSSGLSDISTQVQQYQQFL------DASKALPEFPDVDLQG--KAL PEGIEL--EHLKSFQLLYREHCEAILDVMVN----LQFPLVETLWKTFWR--FSENQAGDSATLAVHD--------ESEK RLPKTCLVILCK----YEPVLRWSRDCDNTLYQGLVEMLIPDVLRPIPSA---LTQA-IRNFAKSLESWLTNAMV--NIP EEMVRVKVTSASAFAQTLRRYTSLNHLAQ-AARAVLQNTAQ-INQMLSDLNRVDFANVQEQAS----WVCRCEDRVVQRL EQ-----------------------DFKLTLQQQN--SLEQWAAWLDGVVS--QVLKPYQS-SAA-LPKAAKLFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMYYLIEHRVAQAKGETPIAVMGEF--------------------ASL GRSLNPLDPDKEEEEE--------------EEEESDDECQELSLQS---DVGAMGDE----------------------- -----------SLEPPAKLARTDQRVLFTTGSMEN--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Takifugu_rubripes_RFX1_a ---------------------MATSGYV------------------GQTDASSTPSSPPQFLAEIQTTVVTPTVVTPTGQ ATPPDQAPSITNPKPSAANQPQPAA-QTQPAQTQYVTAEIQSSPTQSGNPQTAPQYIVVTVTEGSLHSSESVPDSNPPPA VV---------QTGVPTQVVQQVQTAQQV---------IYEHTVAGTDS-LKNYCIKSCQII---TERSVVQATSQITKT E--PGTQLSVTSLQP--VHITPETFLVCLHSISQLALCLLPVQMWQETDMYLVATSFSTARKLRQSTDFPVWDNKGPESE SETILSVECLP----TPQVQQQLSSVPVQHVYTNQVQYVEG-TD------TNYTTSTIRSSTFPYS-------------E TPLYTQT---TPTQ---YYEGQQ---TPGSQASTPGTPLTVSVT-----AGTTG------GVSMFVAQPTSATAGGATVV TTCG--TTNGAGEGAGTNG------------GTAGSYVIQGGY--MLSSSSSGGAASNTQNYSHTARASPAT-------- VQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGLRIKAGSSL L-------------------------------RLMEDQQH----------------------------------LAMRQQ PFSQKQRLKPVHKVEG-MTNGTSAGAGQQQQQ-QQGSGQVDISTQVQQYQQFL------DASRALPEFPDIDLQG--KPL PDGVEL--EHIKSFQVLYREHCEAILDVMVN----LQFTLVETLWKTFWR--FSQSQAGD-ATLAVHD--------ESEK RLPKSCLVLLCK----YEPVLRWSRDCDNSLYQGLVEILIPDVLRPIPSA---LTQA-IRNFAKSLESWLTNAMM--NIP EEMVRIKVTSANAFAQTLRRYTSLNHLAQ-AARAVLQNTAQ-INQMLSDLNRVDFANVQEQAS----WVCRCEDRVVQRL EQ-----------------------DFKLTLQQQN--SLEQWAAWLDGVVS--QVLKPYQH-SPA-FPKAAKLFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMYYLIEHRVAQAKGETPIAVMGEF--------------------ASL GRGLRQLDPDKDEEEE--------------EEEESDEEGQELSLPS---DGAVLGEE----------------------- -----------SLEPPAKLARTDQGVLFTSGSATN--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Tetraodon_nigroviridis_RFX1_a ---------------------MATSGYVGEIQPAVQPQGTGVPVTPGQPDASSTPSTAPQFLAEIQTTVVTPTVVTPTGQ AAPPDKGPSITNQKPSAGSQPQSAT-PNQPAQTQY--------------------YIVVTVTEGSLHSSESVSDSSSPPA VV---------QTGVPTQVVQQVQTAQQV---------ICMNTYSARNRQLEIAETNHCSFT---VQDIYISLLLLLPRA K--EQMIILVMFWIL--EGLRSNDQSQACRSHYWEEKAKVQSSAFSKCFFILCIKQHLVS--FCEKRSVVQATSQIAKTE PGTQLSVTSLQPVHITPEVQQQLTSVPVQHVYTNQVQYVEG-TD------SNYTTSTIRSSTFPYS-------------E TPLYTQT---TATQ---YYEGQQ---TPGSQASTPGTPLTVSVT-----TGTTG------GVSMFVAQPTSATAGGATVV TSCG--TTNGAGEGAGTNG------------GTAGSYVIQGGY--MLSSSNSGGAANNNQNYSHTARASPAT-------- VQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGLRIKAGSSL L-------------------------------RLMEDQQH----------------------------------LAMRQQ PFSQKQRLKPVHKVEG-MTNGTAAGAGQQQQQ-QQGSGQVDISTQVQQYQQFL------DASRALPEFPDIDLQG--KPL PDGVEL--EHIKSFQVLYREHCEAILDVMVN----LQFTLVETLWKTFWR--FSQSQAGD-ATLAVHD--------ESEK RLPKSCLVLLCK----YEPVLRWSRDCDNSLYQGLVEILIPDVLRPIPSA---LTQA-IRNFAKSLESWLTNAMM--NIP EEMVRIKVTSANAFAQTLRRYTSLNHLAQ-AARAVLQNTAQ-INQMLSDLNRVDFANVQEQAS----WVCRCEDRVVQRL EQ-----------------------DFKLTLQQQN--SLEQWAAWLDGVVS--QVLKPYQH-SPA-FPKAAKLFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMYYLIEHRVAQAKGETPIAVMGEF--------------------ASL GRGLRQMDPDK---------------------VSNSDCRQELSLPS---DGAVLGEE----------------------- -----------SLEPPAKLARTDQGVLFTSGSADN--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gasterosteus_aculeatus_RFX1_a ---------------------MATSGYV------------------GEIQPAAQPQGAG-------ATVAAGQPDTGSSP AAAP-QATSVASPKPADVIQVQSTS-QAQPPQTQYVTAEIQGSPTQTGNAHSTPQYIVVTVTEGSLHSSDSLSDSSPPPA VV---------QTGVPTQVVQQVQAAQQ------------QRSVVQATSQIAKTEPGTLSVT---SLQPVHISQEFLPCY D--LAALVSIASAST--GPLR------LLRHRIEQPTMQSQAQASLSRRRKMSGTQGLYSQRICPQLKVITSKATVYARW GKRIHRVCVCA---LIPQVQQQLT--PVQHVYANQVQYVEG-GE------ANYATSTIRSSAFPYT-------------D AALYTQT---TTAQ---YYEGQP---ASGSQASTPGTPITVSVT-----AGAAG------GVSMFVAQPTSAAGGGATVV TAGG--TPNGSVDGAGTNG------------GAAGSYVIQGGY--MLGSG-GGGAAGNSQSYSHTARASPAT-------- VQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGLRIKAGSSL L-------------------------------RLMEDQQH----------------------------------LAMRQQ PFSQKQRLKPVHKVEG-LTN---------------GSGQVDISTQVQQYQQFL------DASLALPDFPDIDLQG--KSP PEGIEL--EHIKSFQLLYREHCEAILDVMVN----LQFTLVETLWKTFWR--FSQNQAGD-ATLAVHD--------ESEK RLPKSCLVLLCK----YDPVLRWSRDCDNSLYQALVEILIPDVLRPIPSA---LTQA-IRNFAKSLESWLTNAMM--NIP EEMVRIKVTSANAFAQTLRRYTSLNHLAQ-AARAVLQNTAQ-INQMLSDLNRVDFANVQEQAS----WVCRCEDRVVQRL EQ-----------------------DFKLTLQQQN--SLEQWAAWLDGVVS--QVLKPYQQ-SPA-FPKAAKLFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMYYLIEHRVAQAKGETPIAVMGEF--------------------ASL GRGLHQLDPDKEEEEE--------------EDDESDDEGQELSLPS---DGGVLGDE----------------------- -----------SLEPPAKLARMDQRVLFATGSADN--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gasterosteus_aculeatus_RFX1_b -------------------------------------------------------------------------------- --------------------------------------------------------LPLASLEGSVHSNDSVSDSSPS-- -----------APGVPSQVVQPVQSTQQ---------------------------------------------------- -------------------------------------------------------------------------------- ------------------VCSLL---QAEHAYSGQVQYVDGGGD------VTFTTSSIRSSDYPFS-------------D SPIYSQTPPTSSS----YYETTP---STEADITGSVTSQSVSVA-----TGGAN-------------CGGGGAGAGGYVI QGGYMLGGGAA--CGGGQT------------FSSPNSRAPPAT--VSTEVPSEQCAVNSQSNRSTVRLPQVQ-------- --WLCDNYEGAEGVSLPRCTLYYHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGLRIKSGSPL L-------------------------------RLMDEQQH----------------------------------MAMRQQ PFSQKNRIKPLHKAQG-ITNG-SGGLGQ------QAAALCDISAQVQQYQQFL------EPSRPLPDFVDIDQQH--GTL PDGVLL--EHLHSFQALYREHCEAILDVMVN----LQFTLVETLWKSFWR--FSQSSDTE--SINLHN--------ESEK RLPKSCLVVLCK----YEPVLRWTKECDNLLYQTLVEILISDVLRPIPSA---LTQA-IRNFAKSLENWLTGAMM--NIP EEMVRIKVVCVGSFSQTLRRYTSLNHLAQ-AARAVLQNTAQ-INQMLSDLNRVDFTNVQEQAS----WVCQCEDRVVQQL EQ-----------------------DFKTTLQQQN--SLEQWATWLDGVVS--EALKPYEHNSAA-LPKAAKVFLLNWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMYYLIEHRVAQAKGVTPIAVMGEG--------------------GDL -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Oryzias_latipes_RFX1_b -------------------------------------------------------------------------------- --------------------------------------------------------SAVSFSEGSAHSNDSLSDSSPS-- -----------APGVPTQAVQPQSVQRQ---------------------------------------------------- -------------------------------------------------------------------------------- ------------------VPVVLNFQQVERVFTGQVQYVDGAGE------SSFPASTIRSNTYPFS-------------D PVIFSQTSSTSSSN---FYEATP---SPGSDIAGSVIAQPVAVA-----TAGG--------------SGGDAAGGGEYAI PVGYIIGGEAAGSAGGSHN------------YGSPNSRAPPAT--VSQNVQKG--AGQTKHLMLLAYFPKVQ-------- --WLCENYEGAEGVSLPRCTLYYHYLLHCQEQKLEPVNAASFGKLIRSVFVGLRTRRLGTR-GNSKYHYYGLRIKSGSPL L-------------------------------RLMDEQQH----------------------------------MAMRQQ PFSQKSRIKPVQKAPG-LSNGIAGGIGQL-----QPGAPGDISTQVQQYQQFL------ETSRPLPEFVDIDLQG--QSL PDGIQL--EHLKVFRDLYREHCEAVLDVMIN----LQFNVVEMLWKSFWR--FSESNNPE--SPDLRNG-SKLKPDDAEN CLPKSLLVLLCK----FEPVLLWTRWCDNLLYQALVDALIPDVLRPIPSA---LTQA-IRNFAKNLESWLTGAMM--NIP EEMVCIKVVCVSSFSQTLRRYTSLNHLAQ-AARAVLQNSAQ-INQMLSDLNRVDFSNVQEQAS----WVCQCEDGVVRRL EQ-----------------------DFKATLQQQN--SLEQWASWLDGVVS--EALKPFEQNPAA-LSKAAKVFLLNWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMYFLVEHRVAQAKGEPPVAVMAEV--------------------RER HSEAP--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Branchiostoma_floridae_RFX1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -SQGHP--VTYPTRASPIT------------------------------------------------------------- IQWLLENYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSVFLGLRTRRLGTR-GNSKYHYYGIRIKATSPL N-------------------------------RLQEDQGH----------------------------------MAMRQQ PINQGKRYMFKPTVPRPEGLGDAGADQAA------SGAGDSSQSQQQQHQQFLG-----DASSALPTFPEISTTS--DPV PSGVTA--DDVKTFQTLYKEHCEAILDVVVN----LQFALIEQVWRTFWR---NPAEGGEGQNDADME-----------K RLTKDKLYILCD----YEPVCAFMRSCDHVFYQSLVEVLIPDVLRPIPSA---LTQA-IRNFAKSLEGWLSAAMT--NIP KKMVKTKLSAVNAFSQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFAHVQEQASWV----CQCDDAVVHRL EQ-----------------------DFKMTLQQQN--SLEAWAVWLDSVVN--QVLKPYEGSET--FPKAARQFLLKWSF Y--R---------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Apis_mellifera_RFX1 MKTDTSFHKRGTNSGSDTVGVERGEGVIAMTTTGAQYALAASTRANNNGGNST-TVGVEPKPSVVVVTTSSSSGSGNAAQ SQSTRGQQLITVVTSSDPSSPNNLQPIQ----DPLEAAADSSNGSTGTPAHVTAQVVVNTTHSGQHTLVDSDAASTSAGT IVS------GSPHFITVTGTSDSPSYASL--------------------------------------------------- -------------------------------------------------------------------------------- -------------TTAVVSGEPEAVGSESVSHPTYVQYVEGDGST-----YIPTNGQMTYPVYAVG----EAGAMYTPAS SQYYTPAT--TPVT---YAQVTGQG----SNSTTGQLLSQGNGTYLIQQSVVDGD----PTAHALISAATARASPQTENT ETVVSGGGGAYLISGNSGNTT----------VTVEDAATAAAN--------------------MTHATRVSQAT------ VHWLLENYETADGVSLPRSTLYNHYLRHCSENKLDPVNAASFGKLIRSVFLGLRTRRLGTR-GNSKYHYYGIRVKPSSPL V-------------------------------MLNED--------------------------------------GTPRQ QQNTNSQTKRFKFVNQKQDTTYENNPHS--------NTNISSNNSPPQYHQYLG-----EASGAIPEFPEIIVGHSS-SL PEDCTL--EDIDTFRSIYREHCEAFLDAVLN----FEFATVESLWREFWR---SQDNNN-GDECEEE------------K YLSKTKLYQMCK----CSEVQDFIRKVDYTFYQNLVEVLMPNVLRPIPSS---LTQS-IRNFAKGLESWLTSAMA--DCP EEMTQIKLTAVSAFAQTLRRYTSLNHLAQ-AARAVLQNSSQ-INQMLADLNRVDFHNVQEQASWV----CQCDYAMVQRL EA-----------------------DFKVTLQQQN--SLEDWAIWLKSVVT--KVLKPFEEKPT--FAKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLIEHQVAVATGTTPIAVMGDKSQ--------------------- --NCSLISAFGATSNG------------------DTSNANQ--------PKRMKLS------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Anopheles_gambiae_RFX1 --------------------MYN-------TSGQGQTQMTYPVYTVGDYG------------------------------ ----------------------------TNGQQQQQQYYTTG-----------------GAYGTAGAGTGS-THTDTTGN ------------------GTSNG--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------TGTTGTGPN----------------------------------------------- GVNGSVSS--GNGG---SAAGNANQQQYIVPVDESVLLGSAGSGNTSGAQQQQSD----SSPQNMTDVASYLHAHQT--- -----------ASVGQELDS---------------APN-------------------------MTHAARVLPAT------ VSWLMENYETADGVSLPRSTLYNHYMWHCNENKLDAVNAASFGKLIRSVFSGLRTRRLGTR-GNSKYHYYGIRIKPTSPL VHAIECKPQHGSGGVGGLGGMVGHHQQLGGSNGLGGGNGTGGNNGMHGHAGGGNHANGLHGSNGSSMAHGGGGGGGGGGG GHLQQGVVGGANGGGGSGGGHGMAMHHGR------GKKNSFKAEMPESCAQYLG-----DPNGAIPQFPIIDMIHP---L PDDITM--EDVDTLRSIYREHCEAFLDAILN----LDFNMIESLWREFWR---AENNNNNGDECEEE------------K YLSKQKLYLLTQ----CEPVQEFVKHVDLQFYQSMVDVLIPDVLRPIPTG---LTQA-IRNFAKNLENWLTSAMG--GCP EPIVAIKLSAVAAFGQTLRRYTSLNHLAQ-AARAVLQNGTQ-IAQMLSDLNRVDFRNVQEQASWI----CQCDTAVVQRL EN-----------------------DFKAALQQQN--TLEQWAGWLQNVVD--DALQEYRGKPS--FVHAARQFLLKWSF Y--SSMVIRDLTLRSAGSFGSFHLIRL-LYDEYMFFIIEHKVAKATNTTPIAVMGEKIN-----------------SRPV QDDLDRMLYTSEYGMV------------------NVKLEPS--------AKRMRS------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Homo_sapiens_RFX2 -------------------------------------------------------------------------------- ---------------------------------------------------------MQNSEGGAD-SPASVALRPSAAA P-----PVPASPQRVLVQAASSNPKGAQ---------------------------------------------------- -------------------------------------------------------------------------------- ------MQP--ISLPRVQQVPQQVQPV-QHVYPAQVQYVEGGD-------AVYTNGAIRTA-YTYNP------------E PQMYAPS---STAS---YFEAPGGA-----QVTVAASSPPAVPS--HSMVGITMD----VGGSPIVSSAGAYLIHGG-MD STRHS---LAHTSRSSPAT----------LEMAIENLQKSEGI--------------------TSHKSGLLNSH------ LQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGIRLKPDSPL N-------------------------------RLQEDTQY----------------------------------MAMRQQ PMHQKPRYRPAQKTDS-LGDSGSHSGL-------HSTPEQTMAVQSQHHQQYI------DVSHVFPEFPAPDLGS--FLL QDGVTL--HDVKALQLVYRRHCEATVDVVMN----LQFHYIEKLWLSFWN--SKASSS-DGPTSLPAS----DEDPEG-A VLPKDKLISLCQ----CDPILRWMRSCDHILYQALVEILIPDVLRPVPST---LTQA-IRNFAKSLEGWLTNAMS--DFP QQVIQTKVGVVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCEESVVQRL EQ-----------------------DFKLTLQQQS--SLDQWASWLDSVVT--QVLKQHAGSPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAEATGETPIAVMGE---------------------FND LASLSLTLLDKDDMGD---------------EQRGSEAGPDARSLGEPLVKRERSD------------------------ -----------PNHSLQGI------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Pan_troglodytes_RFX2 -------------------------------------------------------------------------------- ---------------------------------------------------------MQNSEGGAD-SPASVALRPSAAA P-----PVPASPQRVLVQAASSNPKGAQ---------------------------------------------------- -------------------------------------------------------------------------------- ------MQP--ISLPRVQQIPQQVQPV-QHVYPAQVQYVEGGD-------AVYTNG------------------------ -------------------AAPGGA-----QVTVAASSPPAVPS--HSMVGITMD----VGGSPIVSSAGAYLIHGG-MD STRHS---LAHTSRSSPAT----------LEMAIENLQKSEGI--------------------TSHKSGLLNSH------ LQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGIRLKPDSPL N-------------------------------RLQEDTQY----------------------------------MAMRQQ PMHQKPRYRPAQKTDS-LGDSGSHSGL-------HSTPEQTMAVQSQHHQQYI------DVSHVFPEFPAPDLGS--VLL QDGVTL--HDVKALQLVYRRHCEATVDVVMN----LQFHYIEKLWLSFWN--SKASSS-DGPTSLPAS----DEDPEG-A VLPKDKLISLCQ----CDPILRWMRSCDHILYQALVEILIPDVLRPVPST---LTQA-IRNFAKSLEGWLTNAMS--DFP QQVIQTKVGVVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCEESVVQRL EQ-----------------------DFKLTLQQQS--SLDQWASWLDSVVT--QVLKQHAGSPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAEATGETPIAVMGE---------------------FND LASLSLTLLDKDDMGD---------------EQRGSEAGPDARSLGEPLVKRERSD------------------------ -----------PNHSLQGI------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gorilla_gorilla_RFX2 -------------------------------------------------------------------------------- ---------------------------------------------------------MQNSEGGAD-SPASVALRPSAAA P-----PVPASPQRVLVQAASSNPKGAQ---------------------------------------------------- -------------------------------------------------------------------------------- ------MQP--ISLPRVQQVPQQVQPV-QHVYPAQVQYVEGGD-------AVYTNGAIRTA-YTYNP------------E PQMYAPS---STAS---YFEAPGGA-----QVTVAASSPPAVPS--HSMVGITMD----VGGSPIVSSTGAYLIHGG-MD STRHS---LGHTSRSSPAT----------LEMAIENLQKSEGI--------------------TSHKSGLLNSH------ LQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGIRLKPDSPL N-------------------------------RLQEDTQY----------------------------------MAMRQQ PMHQKPRYRPAQKTDS-LGDSGSHSGL-------HSTPEQTMAVQSQHHQQYI------DVSHVFPEFPAPDLGS--VLL QDGVTL--HDVKALQLVYRRHCEATVDVVMN----LQFHYIEKLWLSFWN--SKASSS-DGPTSLPAS----DEDPEG-A VLPKDKLISLCQ----CDRILRWMRSCDHILYQALVEILIPDVLRPVPST---LTQA-IRNFAKSLEGWLTNAMS--DFP QQVIQTKVGVVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCEESVVQRL EQ-----------------------DFKLTLQQQS--SLDQWASWLDSVVT--QVLKQHAGSPT--FPKALPQPRTETLF H--FSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAEATGETPIAVMGE---------------------FND LASLSLTLLDKDDMGD---------------EQRGSEAGPDARSLGEPLVKRERSD------------------------ -----------PNHSLQGI------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Mus_musculus_RFX2 -------------------------------------------------------------------------------- ---------------------------------------------------------MQNSEGGAD-SPASVALRPAAQ- ------PMPASPQRVLVQAAGSTPKGTP---------------------------------------------------- -------------------------------------------------------------------------------- ------MQT--LTLPRVQPVPPQVQHV----YPAQVQYVEGGD-------AVYANGAIRAA-YAYNP------------D PQLYAPS---SAAS---YFETPGGT-----QVTVAASSPPAVPS--HGMVGITMD----VSGTPIVSGAGAYLIHGG-MD GTRHS---LAHTARSSPAT----------LEMAIETLQKSEGL--------------------APHKGGLLNSH------ LQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLEPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGIRLKPDSPL N-------------------------------RLQEDTQY----------------------------------MAMRQQ PTHQKPRYRPAQKSDS-LGDGSAHSNM-------HGMPDQAMATQGQHHQQYI------DVSHVFPEFPAPDLGS--TLL QESVTL--HDVKALQLVYRRHCEATLDVVMN----LQFQYIEKLWLSFWN--CKATSS-DSCASLPAS----DEDPEV-T LLPKEKLISLCK----CEPILQWMRSCDHILYQTLVETLIPDVLRPVPSS---LTQA-IRNFAKSLEGWLINAMS--GFP QQVIQTKVGVVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCEESLVQRL EH-----------------------DFKVTLQQQS--SLDQWASWLDNVVT--QVLKQHSGSPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FND LASLSLTLLDKEDIG----------------DGHSSEADVDGRSLGEPLVKRERSD------------------------ -----------PSHPLQGI------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Canis_familiaris_RFX2 -------------------------------------------------------------------------------- ----------------------------------------MATPLHSTSLRLSLELSMQNSEGGSD-SPASVALCPSAAA QAPVARPVPASPQRVLVQAAGSAPKGAQ---------------------------------------------------- -------------------------------------------------------------------------------- ------MQP--ISLPRVQQVPQQVQSV-QHVYPPQVQYVEGGD-------AVYTNGALRTA-YAYNP------------E PQMYAPS---SAAS---YFEAPGGA-----QVTVAGSSPPAVPS--HSMVGITMD----VGGSPIVSSAGAYLIHGG-MD STRHS---LAHTSRSSPAT----------LEMAIENLQKSEGI--------------------TSHKSGLLNSH------ LQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGIRLKPDSPL N-------------------------------RLQEDTQY----------------------------------MAMRQQ PMHQKPRYRPAQKTDS-LGDSGSHGSL-------HSTPEQAMAAQSQHHQQYI------DVSHVFPEFPAPDLGS--VLL QESITL--HDVKALQLVYRRHCEATLDVVVN----LQFHYIEKLWLSFWN--SKASSG-DGPASLPAS----DGEPEG-A VLPKDKLVSLCK----CEPILKWMRNCDHILYQALVEILIPDVLRPVPST---LTQA-IRNFAKSLEGWLTNAMR--DFP QQVIQTKVGVVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCEESVVQRL EQ-----------------------DFKLTLQQQS--SLDQWASWLDNVVT--QVLKQHAGSPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAEATGETPIAVMGE---------------------FND LASLSLTLLDKDDIS----------------EDRGSEADPDARSLGEPLVKRERSD------------------------ -----------TNHSLQGI------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gallus_gallus_RFX2 -------------------------------------------------------------------------------- ---------------------------------------------------------MQSSEGGSD-SAASVTLHPSASA QAPVVQPVPASQQRVLVQTAGSAPKGAQ---------------------------------------------------- -------------------------------------------------------------------------------- ------MQQ--ISVPRVQQVPQQVQSVQHV-YPSQVQYVEG-E-------AVYTNG-TIRTAYSYNT------------E AQIYAPS---SAAS---YFEPQGGG----AQVTTAASSPTAIPS--HNMVGITMD----IGGSPILSSSGAYLIHGG-ME NTRHS---LSHTSRSSPAT----------LEMAIENLQKNEGI--------------------TSHKSSLLNSH------ LQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGIRLKPESPL N-------------------------------RLQEDTQY----------------------------------MAMRQQ PIHQKQRYRPAQKMDG-MAEAGSNSSL-------HTTPEQSVAAQSQHHQQFI------DVTHVFPEFPAPDLGN--VLL QEGVTM--NDVKTLQLLYRRHCEATLDVVMN----LQFHYIEKLWQSFWS--PKTPSS-DGSAALPSS----EEEHEG-- TLPKDKLITLCK----YEPILKWMRSCDHILYQALVEILIPDVLRPVPST---LTQA-IRNFAKSLEGWLMNAMS--EFP PQIVQTKVGVVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCEEGMVQKL EQ-----------------------DFKLTLQQQS--SLDQWASWLDNVVT--QVLKHHEGSPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FGD LTSMSPTLLDKDHISD-----------------LGSEVDTDSRSVGEPLVKRERSD------------------------ -----------TGHSLQEI------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Xenopus_tropicalis_RFX2 -------------------------------------------------------------------------------- ---------------------------------------------------------MQNSDSGSD-SATSVALRTSASA QAPVVQPVPASQQRSLSQASGSAPKGAH---------------------------------------------------- -------------------------------------------------------------------------------- ------GQG--ISVPRAHQLQQQVQTVQHV-YPAQVQYVEG-D-------TVYTNG-AIRTAYSYNA------------E AQIYAPS---SGSS---YFDSQGGG----AQVTTVVSSPTAIPS--HSMVGIAMD----VSGSQIISSSGAYLIHGG-LE NSRHT---PSHTSRTFPAT----------LEMAIENLQKNEGI--------------------TSHKSSLLNSH------ LQWLLDNYETAEGVSLPRSSLYNHYLRHCQDHKLDPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGIRLKPDSPL N-------------------------------RLQEDTQY----------------------------------MAIRQQ PIHQKQRYRPAQKMDG-MGENTANSSQ-------HTSPEQSVAAQSQHHQQFIVQ----DTAHVFPDFPEPDLGN--VLL PEGITM--TDIKNLQLMYRRHCEATIDVVMN----LQFQYIEKLWQAFWN--SKPSSP-DGSNPMNS-----EDEQEP-- IIPKDKLMVLCK----YEPIMRWMRNCDHILYQALVEILIPDVLRPVPST---LTQA-IRNFAKSLEGWLTNAMC--DFP QQIVHAKVGVVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCEEGMVQKL EQ-----------------------DFKLTLQQQS--SLDQWANWLDNVVT--QVLKPHEGSPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FSD FASMSPVLMDKDDVSE-----------------LGSDNDGDPRISGQPPVKRERVD------------------------ -----------LNHSMQEM------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Danio_rerio_RFX2_b -------------------------------------------------------------------------------- ---------------------------------------------------------MQRSEGGSE-TPSTVALRTSTSA QAPVVQPVPASQQRVLVQATGSSQKGAQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQQ--LPVPRVQQVPQQVQQV-QHYHSQQVQYV-EGAE------AVYPNGTIRAA-YSYNP------------E SQLYGQG---SGSA---YFDSQAGGA---QVTTVVS--SGGVPT--HGMVGIAMD----VGGSQIISSGSAYLIHGG-ME GGRHH---TSHSSRSSSAM----------LEMAIENLQKSEGI--------------------ATHKSSLLNSH------ LQWLLDNYETAEGVSLPRSSLYNHYLRHCQEQKLDPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGIRLKPDSPL N-------------------------------RMQEDTQY----------------------------------MAMRQT PVHQKQRFKPFHKMDG-MGDSLNSGSQHL-----SSTPEQSVAAQCQHHQQYI------DVSHVLPPFPSLDLGS--CPL PESISM--TDVKKLQSSYRIHCEATLDVVMN----LQFHLIEKLWQTFWH--STAPSS-DGATTIPN----SEEDVEDIR GFPRDKLITLCK----YEPIKQWMRSCDHILYQALVEILIPDVLRPVPST---LTQA-IRNFAKSLEGWLTSAMT--NFP PEIISTKAAVVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCDESVVQRL EL-----------------------DFKATLQQQS--SLDQWAAWLDNVVN--QVLKPYDGSLS--FPRAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FSD LSSLMPSLKEQ-DTSFSD-----------DMTSDGDMSRMSERSLTEPAVKRERIE------------------------ -----------IPHSLQEI------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Takifugu_rubripes_RFX2_a -------------------------------------------------------------------------------- ---------------------------------------------------------MQSSEGGSDSTSSVAALRTTSSA QAPVVQPVPASQQRVLVQVIGSAKKGGQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQQ--LSVPRVQQVTQQVQQV-QHVYPSQVQYVGEGGE------TVYTNGTIRTA-YSYNP------------E AQLYGQS---SGGN---YFDSQGSGG---HVTTVVSSASGGVPP--HGMVGIAMD----VGSSHIISSGSTYLIHGGNME GSRNH---ISHSSRSSSAM----------LDMAIENLQKSEGI--------------------ASHKSSLLNSH------ LQWLLDNYETAEGVSLPRCSLYNHYLRHCQEQKLDPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGIRVKPDSPL N-------------------------------RLQEDTQY----------------------------------MAMRQQ PVHQKPRFKPLQKVDG-MSDSLCGSSQHC-----NSTPEQSVAAQSQHHQQYI------DTSHTLPPFPSPDLSA--PSL PERITV--SDIKKLQNLYRDHCEATLDVVMN----LQFHYIEKLWQTFWY--STAPSS-DGNTAINN---SDDDEVEGA- -IPREKLVALCK----YEPVRLWMRSCDHILYQALVEILIPDVLRPVPST---LTQA-IRNFAKSLEGWLTNAMS--NFP QEIIRTKVAVVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCDESVVQRL EQ-----------------------DFKVTLQQQS--SLDQWATWLDNVVT--QVLKPHQGSRS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FSD LSSMMPSLLDK-DASCTD-----------KMDELG-DADVS-RGPAEPAVKRERIE------------------------ -----------MNHPLQEM------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Tetraodon_nigroviridis_RFX2_a -------------------------------------------------------------------------------- ---------------------------------------------------------MQSSEGASDTTSSVAALRTSSSA QAPVVQPVPASQQRVLVQVIGSAKKGGQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQQ--LSVPRVHQVTPQVQQV-QHVYPSQVQYVGEGGE------TVYTNGTIRTA-YSYNP------------D AQLYGQS---SGGS---YFDSQGGGG---HVTTVVSSASGGVPS--HGMVGIAMD----VGSSHIISSGSTYLIHGGNME GSRNH---VSHSSRSSSAM----------LDMAIENLQKSEGI--------------------ASHKSSLLNSH------ LQWLLDNYETAEGVSLPRCSLYNHYLRHCQEQKLDPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGIRVKPDSPL N-------------------------------RLQEDTQY----------------------------------MAMRQQ PVHQKPRFKPLQKVDG-MSDSVCGSSQHC-----SGTPEQSVAAQSQHHQQYI------DTSHTLPSFPSPDVSP--QSL PERITL--GDIGKLRTLYRDHCEATLDVVMN----LQFHYIEKLWQTFWY--ATAPSS-DGSTAINSFL-CSDDEAEGA- -IPREKLVALCK----YEPVRVWMRSCDHILYQALVEILIPDVLRPVPST---LTQA-IRNFAKSLEGWLTNAMS--NFP QEIIRTKVAVVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCDESVVQRL EQ-----------------------DFKVTLQQQS--SLDQWATWLDNVVT--QVLKPHQGSRS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FSD LSSMMPSLLDKADASCAD-----------KMDELE-DADVS-RGPAEPAVKRERIE------------------------ -----------MSHPLQEM------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gasterosteus_aculeatus_RFX2_a -------------------------------------------------------------------------------- ---------------------------------------------------------MQSSEGGSDTTTSVAALRTSSSA QAPVVQPVPASQQRVLVQATGSAQKGGQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQQ--LSVPRVQQ---QVQQV-QHVYPSQVQYVGEGAD------AVYTNGTIRTA-YSYNP------------E AQLYGQS---SGGT---YFDSQAG------VTTVVSSAGGGVPS--HGMVGIAMD----VGSSHIISGGSTYLIHGGSME GSRNH---ISHASRSSSAM----------LEMAIENLHKSEGI--------------------ASHKSSLLNSH------ LQWLLDNYETAEGVSLPRCSLYNHYLRHCQEQKLDPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGIRVKPDSPL N-------------------------------RLQEDTQY----------------------------------MAMRQQ PVHQKQRFKPLQKVDG-MSDSLCGSSQNC-----NNTPEQSVAAQSQHHQQYI------DTSHNLPPFPSPDLGT--QPL PERINM--NDIKKLHTLYRDHCEATLDVVMN----LQFHYIEKLWQTFWY--STPPSS-DGNTTIQN----SDDDLDGV- -IPREKLVALCK----YEPVRLWMRSCDHILYQALVEILIPDVLRPVPST---LTQA-IRNFAKSLEGWLTNAMT--NFP HEIIRTKVAVVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCDESVVQRL EQ-----------------------DFKVTLQQQS--SLDQWATWLDNVVT--QVLKPHQGSSS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FSD LTSMMPSLMEKVDASFSD-----------EMSDLGSDTDVS-RGPTEPAVKRERIE------------------------ -----------MSHPLQEM------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Oryzias_latipes_RFX2_a -------------------------------------------------------------------------------- ---------------------------------------------------------MQNAEGGSDTTTTVAALRTSSSA QAPVVQPVPASQQRVLVQAVGSAQKGGQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQQ--ISVPRVQQVPQQVQQV-QHVYPSQVQYVGEGGE------AVYTNGNSRTA-YSYNP------------E SQLYGQN---SGGT---YFDSQAGGA---HVTTVVSSASGGVPP--HGMVGIAME----VGSGHIISSGSPYLIHGGSME GSRNH---ISHSSRSSSAM----------LEMAIENLQKSEGI--------------------ASHKSSLLNSH------ LQWLLDNYETAEGVSLPRCSLYNHYLRHCQEQKLDPVNAASFGKLIRSVFMGLRTRRLGTR-GNSKYHYYGIRVKPDSPL N-------------------------------RLQEDTQY----------------------------------MAMRQQ PVHQKQRFKPLQKVDS-MSDSLCGSSQAC-----NSTPEQSVAAQSQHHQHYI------DTSHTLPQFPPLDVGS--QPL PERINM--GDIKKLKTLYRDHCEVGSPLHST----FTXXXXXXLWQTFWC--STAPSS-DGSTSIPS----SDDDMEGS- -IPREKLVALCK----YEPVRLWMRSCDHILYQALVEVLIPDVLRPVPST---LTQA-IRNFAKSLEGWLTNAMT--SFP QEIVRTKVAVVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDXX------------------------ XX-----------------------DFKVTLQQQS--SLDQWATWLDNVVS--QVLKPHQGNPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FSD LSSMMPSLMEK-GKHALF-----------EMSGMGSDADAS-REISEPSVKRERIE------------------------ -----------MSQSLQEM------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Drosophila_melanogaster_RFX2 --------------------MHSRYGFDCQTRHYQQHQQTHHQHHHHHHPNPPCSIPLESPPTPPVISPSAAAAVAYSNL LEKCRCKQSVAANPVPAPPAQLQLQLHHHHHHHHHQTFVASASATSYSNCSALGLGSRTGSGSGSGSGTGS-TPSTSSLA NSS------CAAATNISGGSSNATMYH----------------------------------------------------- -------------------------------------------------------------------------------- -------------HHHRRHNNLSYCGVSGQEQNYQVQYVDSELYH-----SNSSQTQMTYPFCPVGDYQGNGQTAYYSTT GQYGTTSS--AGGS---SNGAHSTTLPYLVPVEEGILLNGSAHSLSQSQSQSHGR----DSPHSLTEVAYIQEAQSTPQT PTSTTT---THSASGGSLGTG----------GGGASPDSDQSA--------------------LGSSNKIASAT------ IKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLGTR-GNSKYHYYGIRIKPGSLL N-----------------------SQAMDDKQMLAAGYGPSSD---------------------------GTGGPGSGPM VSVTSSTAGQLTGSNGLGGGHGQRHSNG-------TKKHTFKPETYEACIQYIG-----DGTSALPSFPPIELNHS---F NSELTL--EDVDTFRGLYREHCESFLDAVLN----LEFNTVEFLLRDFWR---ASDNNN-LDECEEE------------K YLSKTKLYLLCH----CAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNA---LTQA-IRNFAKNLEIWLCESML--GVP EQLAQIKTSAVSAFCQTLRRYTSLNHLAQ-AARAVLQNGAQ-ISQMLSDLNRVDFHNVQEQAAWV----SQCAPAVVQRL ES-----------------------DFKAALQQQS--SLEQWASWLQLVVE--SAMEEYNGKPT--YARAARQFLLKWSF Y--SSMIIRDLTLRSASSFGSFHLIRL-LFDEYMFYLVEHKIAEAQDKTAIAVICERMKK----------------DMDF EFECQFAYITSDTEHQ------------------TTPSSASSGGDVGNEAKRLKQE------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Homo_sapiens_RFX3 -------------------------------------------------------------------------------- ---------------------------------------------------------MQTSETGSDT-GSTVTLQTSVAS QAA-----------VPTQVVQQVPVQQQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQ-----------QVQTVQQV-QHVYPAQVQYVEG-SD------TVYTNGAIRTTTYPYT-------------E TQMYSQN---TGGN---YFDTQG----SSAQVTTVVSSHSMVGT-----GGIQMG----VTGGQLISSSGGTYLIGNSME NSG-HS--VTHTTRASPAT----------IEMAIETLQKSDGL--------------------STHRSSLLNSH------ LQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTR-GNSKYHYYGIRVKPDSPL N-------------------------------RLQEDMQY----------------------------------MAMRQQ PMQQKQRYKPMQKVDG-VADGFTGSGQQT-----GTSVEQTVIAQSQHHQQFL------DASRALPEFGEVEIS----SL PDGTTF--EDIKSLQSLYREHCEAILDVVVN----LQFSLIEKLWQTFWR--YSPSTPTDGTTITESS-----NLSEIES RLPKAKLITLCK----HESILKWMCNCDHGMYQALVEILIPDVLRPIPSA---LTQA-IRNFAKSLEGWLSNAMN--NIP QRMIQTKVAAVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCDDNMVQRL ET-----------------------DFKMTLQQQS--TLEQWAAWLDNVMM--QALKPYEGRPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FGD LNAVSPGNLDKDEGS-----------------EVESEMDEELDDSSEPQAKREKT--ELSQAFPVGCMQP---VLETGVQ PSLLN------PIHSEHIVTS---TQTIRQCSATGNTYTAV--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gorilla_gorilla_RFX3 -------------------------------------------------------------------------------- ---------------------------------------------------------MQTSETGSDT-GSTVTLQTSVAS QAA-----------VPTQVVQQVPVQQQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQ-----------QVQTVQQV-QHVYPAQVQYVEG-SD------TVYTNGAIRTTTYPYT-------------E TQMYSQN---TGGN---YFDTQG----SSAQVTTVVSSHSMVGT-----GGIQMG----VTGGQLISSSGGTYLIGNSME NSG-HS--VTHTTRASPAT----------IEMAIETLQKSDGL--------------------STHRSSLLNSH------ LQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRRGNSKYHYYGIRVKPDSPL N-------------------------------RLQEDMQY----------------------------------MAMRQQ PMQQKQRYKPMQKVDG-VADGFTGSGQQT-----GTSVEQTVIAQSQHHQQFLVVT-VTDASRALPEFGEVEIS----SL PDGTTF--EDIKSLQSLYREHCEAILDVVVN----LQFSLIEKLWQTFWR--YSPSTPTDGTTITESS-----NLSEIES RLPKAKLITLCK----HESILKWMCNCDHGMYQALVEILIPDVLRPIPSA---LTQA-IRNFAKSLEGWLSNAMN--NIP QRMIQTKVAAVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLNDLNRVDFANVQEQASWV----CQCDDNMVQRL ET-----------------------DFKMTLQQQS--TLEQWAAWLDNVMM--QALKPYEGRPS--FPKAARQFLLKWSF YRNSSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FGD LNAVSPGNLDKDEGS-----------------EVESEMDEELDDSSEPQAKREKT--ELSQAFPVGCMQP---VLETGVQ PSLLN------PIHSEHIVTS---TQTIRQCSATGNTYTAV--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Pongo_abelii_RFX3 -------------------------------------------------------------------------------- ---------------------------------------------------------MQTSETGSDT-GSTVTLQTSVAS QAA-----------VPTQVVQQVPVQQQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQ-----------QVQTVQQV-QHVYPAQVQYVEG-SD------TVYTNGAIRTTTYPYT-------------E TQMYSQN---TGGN---YFDTQG----SSAQVTTVVSSHSMVGT-----GGIQMG----VTGGQLISSSGGTYLIGNSME NSG-HS--VTHTTRASPAT----------IEMAIETLQKSDGL--------------------STHRSSLLNSH------ LQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTR-GNSKYHYYGIRVKPDSPL N-------------------------------RLQEDMQY----------------------------------MAMRQQ PMQQKQRYKPMQKVDG-VADGFTGSGQQT-----GTSVEQTVIAQSQHHQQFL------DASRALPEFGEVEIS----SL PDGTTF--EDIKSLQSLYREHCEAILDVVVN----LQFSLIEKLWQTFWR--YSPSTPTDGTTITESS-----NLSEIES RLPKAKLITLCK----HESILKWMCNCDHGMYQALVEILIPDVLRPIPSA---LTQA-IRNFAKSLEGWLSNAMN--NIP QRMIQTKVAAVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLNDLNRVDFANVQEQASWV----CQCDDNMVQRL ET-----------------------DFKMTLQQQS--TLEQWAAWLDNVMM--QALKPYEGRPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FGD LNAMSPGNLDKGKNR-----------------K----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Macaca_mulatta_RFX3 -------------------------------------------------------------------------------- ---------------------------------------------------------MQTSETGSDT-GSTVTLQTSVAS QAA-----------VPTQVVQQVPVQQQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQ-----------QVQTVQQV-QHVYPAQVQYVEG-SD------TVYTNGAIRTTTYPYT-------------E TQMYSQN---TGGN---YFDTQG----SSAQVTTVVSSHSMVGT-----GGIQMG----VTGGQLISSSGGTYLIGNSME NSG-HS--VTHTTRASPAT----------IEMAIETLQKSDGL--------------------STHRSSLLNSH------ LQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTR-GNSKYHYYGIRVKPDSPL N-------------------------------RLQEDMQY----------------------------------MAMRQQ PMQQKQRYKPMQKVDG-VADGFTGSGQQT-----GTSVEQTVIAQSQHHQQFL------DASRALPEFGEVEIS----SL PDGTTF--EDIKSLQSLYREHCEAILDVVVN----LQFSLIEKLWQTFWR--YSPSTPTDGTTITESS-----NLSEIES RLPKAKLITLCK----HESILKWMCNCDHGMYQALVEILIPDVLRPIPSA---LTQA-IRNFAKSLEGWLSNAMN--NIP QRMIQTKVAAVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLNDLNRVDFANVQEQASWV----CQCDDNMVQRL ET-----------------------DFKMTLQQQS--TLEQWAAWLDNVMM--QALKPYEGRPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FGD LNAVSPGNLDKDEGS-----------------EVESEMDEELDDSSEPQAKREKT--ELSQAFPVGCMQP---VLETGVQ PSLLN------PIHSEHIVTS---TQTIRQCSATGNTYTAV--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Mus_musculus_RFX3 -------------------------------------------------------------------------------- ---------------------------------------------------------MQTSETGSDT-GSTVTLQTSVAS QAA-----------VPTQVVQQVPVQQQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQ-----------QVQTVQQV-QHVYPAQVQYVEG-SD------TVYTNGAIRTTTYPYT-------------E TQMYSQN---TGGN---YFDTQG----SSAQVTTVVSSHSMVGT-----GGIQMG----VTGGQLISSSGGTYLIGNSME NSG-HS--VTHTTRASPAT----------IEMAIETLQKSDGL--------------------STHRSSLLNSH------ LQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTR-GNSKYHYYGIRVKPDSPL N-------------------------------RLQEDMQY----------------------------------MAMRQQ PMQQKQRYKPMQKVDG-VADGFTGSGQQT-----GTSVEQTVIAQSQHHQQFL------DASRALPEFGEVEIS----SL PDGTTF--EDIKSLQSLYREHCEAILDVVVN----LQFSLIEKLWQTFWR--YSPSTPADGTTITESS-----NLSEIES RLPKAKLITLCK----HESILKWMCNCDHGMYQALVEILIPDVLRPIPSA---LTQA-IRNFAKSLEGWLSNAMN--NIP QRMIQTKVAAVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCDDNMVQRL ET-----------------------DFKMTLQQQS--TLEQWAAWLDNVMM--QALKPYEGRPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQVTGETPIAVMGE---------------------FGD LNAVSPGNLDKDEGS-----------------EVESETDEDLDDSSEPRAKREKT--ELSQAFPVGCMQP---VLESAVQ PSLLN------PLHSEHIVTS---TQTIRQCSATGNTYTAV--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Canis_familiaris_RFX3 -------------------------------------------------------------------------------- ---------------------------------------------------------MQTSETGSDT-GSTVTLQTSVAS QAA-----------VPTQVVQQVPVQQQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQ-----------QVQTVPQV-QHVYPAQVQYVEG-SD------TVYTNGAIRTTTYPYT-------------E TQMYSQN---TGGN---YFDTQG----SSAQVTTVVSSHSMVGT-----GGIQMG----VTGGQLISSSGGTYLIGNSME NSG-HS--VTHTTRASPAT----------IEMAIETLQKSDGL--------------------STHRSSLLNSH------ LQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTR-GNSKYHYYGIRVKPDSPL N-------------------------------RLQEDMQY----------------------------------MAMRQQ PMQQKQRYKPMQKVDG-VADGFTGSGQQT-----GTSVEQTVIAQSQHHQQFL------DASRALPEFGEVEIS----SL PDGTTF--EDIKSLQSLYREHCEAILDVVVN----LQFSLIEKLWQTFWR--YSPSTPTDGTTITESS-----NLSEIES RLPKAKLITLCK----HESILKWMCNCDHGMYQALVEILIPDVLRPIPSA---LTQA-IRNFAKSLEGWLSNAMN--NIP QRMIQTKVAAVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLNDLNRVDFANVQEQASWV----CQCDDNMVQRL ET-----------------------DFKMTLQQQS--TLEQWAAWLDNVMM--QALKPYEGRPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGETYLVDEKKTPIMELFISKLLNFGD LNAVSPGNLDKDEGS-----------------EVESEMDEELDDSSEPQAKREKT--ELNQAFPVGCMQP---VLEGGVQ PSLLN------PIHSEHIVTS---TQTIRQCSATGNTYTAV--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gallus_gallus_RFX3 -------------------------------------------------------------------------------- ---------------------------------------------------------MQTSEAGSDT-GSTVTLQTSVAG QAA-----------VPTQVVQQVPVQQQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQ-----------QVQTVQQV-QHVYPTQVQYVEG-SD------TVYTNGAIRSTTYPYT-------------E TQMYSQN---TGGN---YFDTQG----SSAQVTTVVSSHSMVGT-----GGIQMG----VTGGQLISSSGGTYLIGNSME NSG-HS--VTHTTRTSPAT----------IEMAIETLQKSDGL--------------------STHRSSLLNSH------ LQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTR-GNSKYHYYGIRVKPDSPL N-------------------------------RLQEDMQY----------------------------------MAMRQQ PMQQKQRYKPMQKVDG-VADGFTGSGQQT-----GTSVEQTVIAQSQHHQQFL------DASRVLPEFGEVEIS----SL PDGTTF--EDIKSLQSLYREHCEAILDVVVN----LQFSLIEKLWQTFWR--YSPSTPPDGTTVNEPS-----NLSEIES RLPKAKLITLCK----NESILKWMCNCDHVMYQALVEILIPDVLRPIPSA---LTQA-IRNFAKSLEGWLSNAMN--NIP QRMIQTKVAAVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLNDLNRVDFANVQEQASWV----CQCDDNMVQRL ET-----------------------DFKMTLQQQS--TLEQWAAWLDNVMM--QALKPYEGRPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FGD LNAVSPGNMDKDEGS-----------------EVESEIDEEMDENGEPQAKREKT--ELNQAFQVGCMQP---VLESGVQ QNLLN------PIHNEHIVAT---TQTIRQCSATGNTYTAV--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Anolis_carolinensis_RFX3 -------------------------------------------------------------------------------- ---------------------------------------------------------MQTSETVSDT-GSTVTLQTSVAG QAA-----------VPTQVVQQLPVQQQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQ-----------QVQTVQQV-QHVYPAQVQYVEG-SD------TVYTNGAIRTTTYPYT-------------D TQMYSQN---TGGN---YFDTQG----SSAQVTTVVSSHSMVGT-----GGIQMG----VTGGQLISSTGGTYLIGNSME NSG-HS--VTHTTRASPAT----------IEMAIETLQKSDGL--------------------STHRSSLLNSH------ LQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTR-GNSKYHYYGIRVKPDSPL N-------------------------------RLQEDMQY----------------------------------MAMRQQ PMQQKQRYKPMQKVDG-VADGFT-SGQQT-----GTSVEQTVIAQSQHHQQFL------DASRALPEFGEVEIS----SL PDGTTF--EDIKSLQSLYREHCEAILDVVVN----LQFSLIEKLWQTFWR--YSPSPTTDGTTITESS-----NLSEIES RLPKAKLITLCK----NESILKWMCNCDHVMYQALVEILIPDVLRPIPSA---LTQA-IRNFAKSLEGWLSNAMN--NIP QRMIQTKVAAVSAFAQTLRRYTSLNHLAQ-AARAVLQNTSQ-INQMLSDLNRVDFANVQEQASWV----CQCDDNMVQRL ET-----------------------DFKMTLQQQS--TLEQWAAWLDNVMM--QALKPYEGRPS--FPKAARQFLLKWSF Y--SSMVIRDLTLRSAASFGSFHLIRL-LYDEYMFYLVEHRVAQATGETPIAVMGE---------------------FGD LNAISPGNMDKDEGS-----------------EVDSEIDEELDEAGEPQAKREKT--EISQAFQVGCLQPV--VLESGVQ QNLLS------PLHNEHIVTA---TQTIRQCSTTGNTYTAV--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Xenopus_tropicalis_RFX3 -------------------------------------------------------------------------------- ---------------------------------------------------------MQTSETVSDT-GSTVTLQTSVAG QAA-----------VPTQVVQQVPVQQQ---------------------------------------------------- -------------------------------------------------------------------------------- ------VQ-----------QVQTVQQV-QHVYPAQVQYVEG-SD------TVYTNGAIRTTTYPYT-------------E TQMYSQN---TGGN---YFDTQG----GSAQVTTVVSTHSMVGT-----GGIQMG----VTGGQIISSTGGTYLIGNAME NSG-HS--VSHTTRASPAT----------IEMAIETLQKSDGL--------------------SSHRSSLLNSH------ LQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTR-GNSKYHYYGIRVKPDSPL N-------------------------------RLQEDMQY----------------------------------MAMRQQ PMQQKQRYKPMQKVDG-VGDGFAGSGQS------GASVEQTVIAQSQHHQQFL------DASRALPEFAEVEIS----SL PDGTTF--EDIKSLQSLYREHCEAFVCLVID----FGFSLFTKALTCFPN--LPX-SPADGSTITESG-----NL