>Homo_sapiens_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MAKWLNKYFSLGNS---KTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSAS SGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSG---EPGGVQRAFSASSASGAAGCCCAS SGAGAAASSSSSSGSPHLYRSSSERRPA-----------------------TPAEVRYISPKHRLIKVESAAG---GGAG DPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYS------------------DPFDAKNDLKSK AGKG-----------ESAGYMEPYEAQRIMT-------------------------------------EFQRQES----- ---------------------------------VRSQHKGIQLYDTPYEPE-------------GQSVDSDSEST--VSP RLRES-------------------------------KLPQDDDRPADEYDQPWEWNRVTIPALA---------------- ----------------------------------AQFNGNEKRQSSPSPSR----------------------------- --------------DRRRQL--RAPGGGFKPIKH---------------------------------------------- -----------------------------------------------------GSPEFCGILGERVDPAVP------LEK QI-------------------WYHGAISRGDAEN-----------LLRLCKECSYLVRNS---------------QTSKH DYSLSLRSNQG---------------------------FMHMKLAKTKE-K----------------------------- -----YVLGQNSPPFDSVPEVIHYYTT-------------------------RKLPIKGAEHLSLLYPVAV----RTL-- ------------------------------------------------------------------ >Gorilla_gorilla_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------PGSSLRKLRAMCRLDYCGGSG---EPGGVQRAFSASSASGAAGCCCAS SGAGAAASSSSSSGSPHLYRSSSERRPA-----------------------TPAEVRYISPKHRLIKVESVAG---GGAG DPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYS------------------DPFDAKNDLKSK AGKG-----------ESAGYMEPYEAQRIMT-------------------------------------EFQRQES----- ---------------------------------VRSQHKGIQLYDTPYEPE-------------GQSVDSDSEST--VSP RLRES-------------------------------KLPQDDDRPADEYDQPWEWNRVTIPALA---------------- ----------------------------------AQFNGNEKRQSSPSPSR----------------------------- --------------DRRRQL--RAPGGGFKPIKH---------------------------------------------- -----------------------------------------------------GSPEFCGILGERVDPAVP------LEK QI-------------------WYHGAISRGDAEN-----------LLRLCKECSYLVRNS---------------QTSKH DYSLSLRSNQG---------------------------FMHMKLAKTKE-K----------------------------- -----YVLGQNSPPFDSVPEVIHYYTT-------------------------RKLPIKGAEHLSLLYPVAV----RTL-- ------------------------------------------------------------------ >Pongo_abelii_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------LDYCGGSG---EPGGVQRAFSASSASGAAGCCCAS SGAGAAASSSSSSGSPHLYRSSSERRPA-----------------------TPAEVRYISPKHRLIKVESAAA---GGAG DPLGGACASGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVIIADDYS------------------DPFDAKNDLKSK AGKG-----------ESAGYMEPYEAQRIMT-------------------------------------EFQRQES----- ---------------------------------VRSQHKGIQLYDTPYEPE-------------GQSVDSDSEST--VSP RLRES-------------------------------KLPQDDDRPADEYDQPWEWNRVTIPALA---------------- ----------------------------------AQFNGNEKRQSSPSPSR----------------------------- --------------DRRRQL--RAPGGGFKPIKH---------------------------------------------- -----------------------------------------------------GSPEFCGILGERVDPAVP------LEK QI-------------------WYHGAISRGDAEN-----------LLRLCKECSYLVRNS---------------QTSKH DYSLSLRSNQG---------------------------FMHMKLAKTKE-K----------------------------- -----YILGQNSPPFDSVPEVIHYYTT-------------------------RKLPIKGAEHLSLLYPVAV----RTL-- ------------------------------------------------------------------ >Mus_musculus_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MAKWLNKYFSLGNS---KTKSPPQPPRPDYREQRRRGERREQPPQAVPQACSASSASCG-SAAACFSAS SGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGGGGG-DPGGGQRAFTA--AAGAAGCCCAA AGAGAAASSSSSSGSPHLYRSSSERRPT-----------------------TPAEVRYISPKHRLIKVESAS-----AAG DPPGGVCSGGRTWSPTTCGGKKLLNKCSA---EETGAGQKDKVTIADDYS------------------DPFDAKSDLKSK AGKG-----------ESAGYMEPYEAQRIMT-------------------------------------EFQRQES----- ---------------------------------VRSQHKGIQLYDTPYEPE-------------GQSVDSDSEST--VSL RLRES-------------------------------KLPQDDDRPADEYDQPWEWNRVTIPALA---------------- ----------------------------------AQFNGNEKRQSSPSPSR----------------------------- --------------DRRRQL--RAPGGGFKPIKH---------------------------------------------- -----------------------------------------------------GSPEFCGILGERVDPTIP------LEK QI-------------------WYHGAISRSDAEN-----------LLRLCKECSYLVRNS---------------QTSKH DYSLSLKSNQG---------------------------FMHMKLAKTKE-K----------------------------- -----YVLGQNSPPFDSVPEVIHYYTT-------------------------RKLPIKGAEHLSLLYPVAV----RTL-- ------------------------------------------------------------------ >Rattus_norvegicus_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MAKWLNKYFSLGNS---KTKSPPQPPRPDYREQRRRGERREQPPQAVPQACSASSASCG-SAAACFSAS SGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGG--G-DPGGGQRAFTA--AAGAAGCCCAA AGAGAAASSSSSSGSPHLYRSSSERRPA-----------------------TPAEVRYISPKHRLIKVESAG-----AAG DPPGGVCSGGRTWSPTTCGGKKLLNKCAA---EETGAGQKDKVTIADDYS------------------DPFDAKNDLKSK AGKG-----------ESAGYMEPYEAQRIMT-------------------------------------EFQRQES----- ---------------------------------VRSQHKGIQLYDTPYEPE-------------GQSVDSDSEST--VSL RLRES-------------------------------KLPQDDDRPADEYDQPWEWNRVTIPALA---------------- ----------------------------------AQFNGNEKRQSSPSPSR----------------------------- --------------DRRRQL--RAPGGGFKPIKH---------------------------------------------- -----------------------------------------------------GSPEFCGILGERVDPTIP------LEK QI-------------------WYHGAISRSDAEN-----------LLRLCKECSYLVRNS---------------QTSKH DYSLSLKSNQG---------------------------FMHMKLAKTKD-K----------------------------- -----YVLGQNSPPFDSVPEVIHYYTT-------------------------RKLPIKGAEHLSLLYPVAV----RTL-- ------------------------------------------------------------------ >Canis_familiaris_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MAKWLHIRGSLGNS---KTKSPPQPPRPDYREQRRRGERPSQAPQAVPQAPAGASASCGPTAASCFSTS SGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGGG---EPGGGQRAFSASSASGAAGCCCAS SGAGAAASSSSSSGSPHLYRSSSERRPA-----------------------TPAEVRYISPKHRLIKVESAA----GGAG DLPGGACSGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYS------------------DPFDAKNDLKSK AGKG-----------ESAGYMEPYEAQRIMT-------------------------------------EFQRQES----- ---------------------------------VRSQHKGIQLYDTPYEPE-------------GQSVDSDSEST--VSP RLRES-------------------------------KLPQDDDRPADEYDQPWEWNRVTIPALA---------------- ----------------------------------AQFNGNEKRQSSPSPSR----------------------------- --------------DRRRQL--RAPGGGFKPIKH---------------------------------------------- -----------------------------------------------------GSPEFCGILGERVDPAVPPT----GSR IY-------------------WYHGAISRGDAEN-----------LLRLCKECSYLVRNS---------------QTSKH DYSLSLKSNQG---------------------------FMHMKLAKTKE-K----------------------------- -----YVLGQNSPPFDSVPEVIHYYTT-------------------------RKLPIKGAEHLSLLYPVAV----RTL-- ------------------------------------------------------------------ >Equus_caballus_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MCRLDYCGGGG---EPGGGQRAFSASSASGAAGCCCAS SGAGAAASSSSSSGSPHLYRSSSERRPA-----------------------TPAEVRYISPKHRLIKVESAA----GGAG DPPGGACSGGRTWSPTASGGKKLLNKCAASAAEESGAGKKDKVTIADDYS------------------DPFDAKNDPKSK AGKG-----------ESAGYMEPYEAQRIMT-------------------------------------EFQRQES----- ---------------------------------VRSQHKSIQLYDTPYEPE-------------GQSVDSDSEST--VSP RLRES-------------------------------KLPQDDDRPADEYDQPWEWNRVTIPALA---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Dasypus_novemcinctus_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MKLARGGREIRSLSGARRRRGCRS--RGAAGRRRR-RELELGVFSGRPGRPPPGPGRRGAWAAALSPGWPRRRTG LPRRGPRRPLAMAKWLNKYFSLGNS---KTKSPPQPPRPDYREQRRRGERPSQHPQAIPQAP--ASASCGPAAASCFSAS SGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGGG---EPGGGQRAFSASSASGAAGCCCAS SGAGAAASSSSSSGSPHLYRSSSERRPA-----------------------TPAEVRYISPKHRLIKVESAAC---GGAG DSPGGACSGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYS------------------DPFDAKNDLKSK AGKG-----------ESAGYMEPYEAQRIMT-------------------------------------EFQRQES----- ---------------------------------IRSQHKGIQLYDTPYEPD-------------GQSFDSDSEST--VSP RLRES-------------------------------KLPQDDDRPADEYDQPWEWNRVTIPALA---------------- ----------------------------------AQFNGSEKRQSSPSPSR----------------------------- --------------DRRRQL--RAPGGGFKPIKH---------------------------------------------- -----------------------------------------------------GSPEFCGILGERVDPAIP------LEK QI-------------------WYHGAISRGDAEN-----------LLRLCKECSYLVRNS---------------QTSRH DYSLSLK------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Gallus_gallus_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MAKWLNKYFSLGNN---KTKSPPQPPRPDYREKRNGAGGAPRPDGPPHLHRHQHHTSPGFPHRHLR--- --------DDTSELLRAYRAQKDRDFEDPYSGPGSSLRKLRALCRPEPCAPDE----------------PGPAAPRAFSS ASCGAAASAP--AGSPLLARSQSERRPG-----------------------TPPEVRYISPRHRLIRVEIGDG------- -------------GRFGRGGEQLA----------ASAPAKEKVLIADDYS------------------DPFDAKSELN-K MVKG-----------ENTGYMEPYEAQRIMT-------------------------------------EFQKQEG----- ---------------------------------MKTHQKNMQLYDTPYEPE-------------GSGVESDSESV--VSQ RLRES-------------------------------KLPQDDDRPADEYDQPWEWNKVTIPALA---------------- ----------------------------------AQFNGSEKRQASPSSSN----------------------------- --------------DQRRQL--RAPGRGFKPIKH---------------------------------------------- -----------------------------------------------------GSPEFCGILGERIDPTVP------LEK QI-------------------WYHGAISRTDAEN-----------LLRLCKECSYLVRNS---------------QTSKH DYSLSLKSSQG---------------------------FMHMKLTKTKE-K----------------------------- -----YILGQNSPPFDSVPEVIHYYTT-------------------------KKLPIKGAEHLSLLYPVAV----RTL-- ------------------------------------------------------------------ >Xenopus_tropicalis_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MAKWLNKYFSLGNNNNNKSKSPPQPPRPDYK--RNGGTERSFHLQYP------------GGQQQFYKHH TSPLPGHCREESDLIRAYRAQKDRDFEDPYNGPGSSLRKLRAMCREEQQGEGR--------RGCTDGTNCFLQESYHGGG SSTNTTSSSSSSSSSPHLYRSNSERRPAGA---------------KQQLTGGSEHKYMVSPKHRLIKIDSCG---WGENG TGGGGAGTVGITWSPVVTP---VTNKTEE---QGNPGAKKEKVIIADDYS------------------DPFDAKSEQKIK GIKT-----------ENNGYMEPYEAQRLMT-------------------------------------DIQKNES----- ---------------------------------QKSLQKNIQLYDTPYEPE-------------SNGVESDSESI--VGL KLRES-------------------------------KLPQDDDRPADEYDQPWEWN-KALPALA---------------- ----------------------------------AQFNGGEKMQS-LSPSN----------------------------- --------------DRRRQL--RAPGGGFKPIKH---------------------------------------------- -----------------------------------------------------GSPDVCGILGERVDPNIA------LEK QI-------------------WYHGAISRTDAEN-----------LLRLCKECSYLVRNS---------------QTSKH DFSLSLKSSQG---------------------------FMHMKLSKTKE-K----------------------------- -----YILGQNSPPFESVPEVVHFYTT-------------------------RKLPIKGAEHLSLLYPVPV----RTL-- ------------------------------------------------------------------ >Strongylocentrotus_purpuratus_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MSKFLNKIFPGKKNASTRGEYLGGRPYDYCSNSLGDLTADNTPIQPASSLSSFHAGLSSASTSSTNQQY HRNGPHDSHTSSDRYRHHSTEDDGAGVTDEFVFRGAGALNLVTNGNRRISDGGSGGDGLRRNEMGAEPRSPTSKKPIVMD DYSDPKDVLKAVQESGMVIPPQKPEMVQP-------------------YPEDDYSVPYEAQRMIKMMRQSEEQKKGEEKK KEGKKGSRHTDDPEGWSVPKGKERFKHHTYEEPPDVSPPIRRSETPDSYVGESS--------------DELNGHSPASMS PSPHRQVN--YSKDHHSSSPMSSESADDTYP-------------------------------------PMHSSSSQN--- ----------------------------HRQQTPQHDRRPTAEYDNPWEWSN----------MKMAKLGPSPEGLEGPRG RSRSELPAN-R----------------------VMRTSPESDTRPGDEYDAPWEWMPMNRKLSQAITDK----------- ----------------------------------EKHHAGRISPLPETPTRG---------------------------- ----------------AKKGNMKLDIKSRPVEMP---------------------------------------------- --------------------------------------------------------------GEPVDPNIP------LTH QT-------------------WYHGKLSRSDAEK-----------KLKLCVEGSYLVRQS---------------ESAAR DYSLSLKSAKG---------------------------FMHMKIVFNHQSD----------------------------- ----GYILGEFSKPFPSISEMICYYTR-------------------------QKLNIRGAEHMALLHPVIDQLL------ ------------------------------------------------------------------ >Apis_mellifera_SHB MERVWRRVQGAGRRS----------ATARCGCPVQPCQLHVDQRAKRGGGRKSRGGPQTIVCSCQVQPCPVHPVLIR--- ----VRRTRPGVGNCDCPPESQPCPHVARTSAVRRIRRCDCPERPCRHSAAGGGTRHRVSVQPSSPTFSQASQSNQQQQQ QQQQQPCECAERINCTHTGGGGECECGEEAKPCSHTVRQRRSRRTCDCSGSGSQPCSHKPQHEG------------RIKR VKCRVRRAGCAMARCTAELAMLHLHWGLATECAPCRPR----------ALTRRLCR-RQQSDNELYRSNSFKFERFER-- SKDECATPLRKQVSLCDDYSLPVDFVNKR--------------------------------------------RPASAAA ATSTVQWA------------------------------------------------------------------------ -------------------------LPSPTVENAEVEVVEQYSDPKDSKNKAYVEPGAETSLPTIYSKVNRN-------- --YCRPYTDPSASGSSCEDDEESRQVDIRK---------------RKNSLYASTSTRAPSIDREKELSSAEG--ALVDCV ALVHLTDQSPTESNQP------------------------------VRHPSPYYYGDLFK-------------------- ---------------------------VPEQISKSQPNRYRKSVSLDVPGERSR----------------TPGIPKRNSV AGDGGSYS---SQQQQPQQQQQSQQPLHYQQQQQQQLQLQQHQLQQHYQSQDLVS--PTSGSEHAVPARSEILSSCIIT- -----EWDHTLMPPHRLLSHDLPTTVCTCVASAEEEEDELDQRQPQLTRHQVRKLRRTRRIDPQ---------------- ---PILVEDEDDVEGEDEGEEEEEEDVEVEEDEEEMA--RQRHLYETAFDCKVNRSDDDLDDLDRVTNHPVLHSQIRSSS AIPVSRTSSSTDTSKQQQQQQAPYAGQSHSNKDRRKVVLLRPKPIPSRLQQQQQQQQQQSDNISTLSQDIESLQINSSDE KTGSPRLPARGYTPSPPSTAPLPAKFHGNRDHLLLN--IRSTPNLPSQ-PDHPRLKDLRLPVKSSLRAKDSPQSSEGSIL EIKSRPKSFAQETVESSQGRRFDKELILEFKGRPREDRQRPRSLIRESKPIMEFK------------GRPHEAESDLLRP RRDVGLLEFKLRTSRRRPGYSSTESMATSSSGGS--------------------------------MESLRSSTSEGNRS TSSSESRHSTSLSSHSSD-----SG----GTNCYHHHQQPSMTGFLTHHAN-----KLHILSPISDKSSQEPASETSDNN RNNNSQK-----------------------------ASPEENVTTENNVTATNNVTNTNTTGNTNSVTSPMDTSFKKRRT PQNKNLIN----------------LALQSSSSGDAEIQGSDSGISIESRAGIKCKPFGFHLLKPQLDNINLVDNE----- -PELSDLPFDMPKLRRRRLLMQQDATTSGSATSVDLRDLPFDMPKLKRRLRC---------MQSTESSGS-QASSSLSVR -DVEPPALFGGGLARPKMTLNLDAGNGTGNGGNSGQLPPKKPGGLSLGLPLEINTARG---SADLVDVGLP------LER QG-------------------WYHGSITRIEAEA-----------VLRLLREGSYLVRNS---------------ESTKQ DYSLSLKSARG---------------------------FMHMRIQKNEELN----------------------------- ----AYILGQFSKPFDSIPEMVRHFSVN-------------------------RLPIRGAEHMCLLHPVIAQLL------ ------------------------------------------------------------------ >Caenorhabditis_elegans_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------MMMTMAADYG------------------------------ --------------SSEGHYDTPWEFLARPN------------------------------------------------- -------------------------------------SVRFSTADVRLS------------------------------- -------------------------------------TSAAGDAKVSPHGSPSLCSSSSFVNQL---------------- ----------------------------------VQIGNSAVDARRKVPRD----------------------------- --------------ESKRR------------------------------------------------------------- --------------------------------------------------------------RP-------------SDS EI-------------------YMEQNMNRVEAEK-----------RLENRNLGDYLLRS-----------------RGEG SAALSLRATKG---------------------------VVHIKIEWNGEK------------------------------ -----WVIGE-GPLFRSISSAISFYRR-------------------------HPLPIRGADHLVLKNQLKPV-------- ------------------------------------------------------------------ >Nematostella_vectensis_SHB -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------MSKKSNK LSRTFPGRVKNETKSRQPLPSGFKRFADFLTLRRKKRKGDSAARQLEKSPWFHGKITAEYAEMLMRGAGEFLVREDPAMP GMYFIAVRNKEQETLHLAITKVNHSKGTRIKYRVEDSDYMFDGIPELIQFYISERRPVSIRPPAVLTIAISKESALLKEE DFRGRTSTAGSARIHRTTRGRLERKRSDPVLSTRVPSRVFNIEADDDSSASVPDKDRPHSRSNPPSIYYDDKQKTAEGGE LFSSATTQSLEDVLDPPQIERRRHLSSSGSAPSLYRKRDSGEGPESTYDSPRSIAIPTTTLKHVSPYGRQGRKRSQESGP VQALKSKEGVPLKDYATPSSLPVNGSSNSQDELDYDVPRPSSMVTDKNNDDTNSKRDSGVTRESSTERDRAGSGVTECAK PRQTRQEIYQSVLQKLRDKIVRPFLEQSCVTLARYMTKVDLDVVWTSHMGEG-----------EGEPEGVAEGLELLILP QGRDIRSALIERYTNLTYWVGALVVAAGDLGPRTQVVTKLIELADVLSDKHGNLVSFMAVLEGLALPQVTRLHHTWSCLH HQYSSSAIMYHSTLKPLAGLLSSGAPSPFPGVCLPYVVPLAKLLEMTTEDALGGWGQDDVVQGIETLLAHLDAG------ ------------------------------RTLIQQLDAYKDEYLKRSHETIPED------------------------- -------ELKIMDYFRSRVNVGDVLGLGSDAHVR---------------------------------------------- ---------------------------------------------------TQKLVTLLNWLSENAERASKPSADIWQAT NAMAISIVCKPFDFFAIMKSGRLKGQIGRMNRGANLSAKIRLFSLHLKFPTDEKFTISRVCPGMTVKDLKNRIELETGVP RHLLRLRYLDGYDLTDDRRLSYYNMVPAATVQVLLWPEWVSLVTAACKGDYYGNQIGVFNFFRG------------VLAS QIRTPAKLGQNTPREFNEKALVALYIASHRGHVNVVSRLVESGVYPCTKLPSGRSPLHAAVNRKQITCVSILIGELYIDR VILSSAGRD--------------------------------------------------------- >Homo_sapiens_SHD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNL DFEDPYED-AESRLEPDPAG--------------------------PGDSKNPGDAKYGSPKHRLIKVEAAD-------- ---------------MARAKALLGGPGEE-------------LEADTEYL------------------DPFDAQPHP--- -------------APPDDGYMEPYDAQWVMS-------------------------------------ELPG-------- --------------------------------------RGVQLYDTPYEEQ------------DPETADGPPSG-----Q KPRQS-------------------------------RMPQEDERPADEYDQPWEWKKDH-ISRAFA-------------- ----------------------------------VQFDSPEWERTP---------------------------------- --------------GSAKEL--RRPPPRS--------------------------------------------------- -----------------------------------------------------------PQPAERVDPALP------LEK Q-------------------PWFHGPLNRADAES-----------LLSLCKEGSYLVRLS---------------ETNPQ DCSLSLRSSQG---------------------------FLHLKFARTRENQ----------------------------- -----VVLGQHSGPFPSVPELVLHYSS-------------------------RPLPVQGAEHLALLYPVVT----QTP-- ------------------------------------------------------------------ >Pan_troglodytes_SHD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNL DFEDPYED-AESRLEPDPAG--------------------------PGDSKNPGDAKYGSPKHRLIKVEAAD-------- ---------------MARAKALLGGPGEE-------------LEADTEYS------------------DPFDAQPHP--- -------------APPDDGYMEPYDAQWVMS-------------------------------------ELPG-------- --------------------------------------RGVQLYDTPYEEQ------------DPETADGPPSG-----Q KPRQS-------------------------------RMPQEDERPADEYDQPWEWKKDH-ISRAFA-------------- ----------------------------------VQFDSPEWERTP---------------------------------- --------------GSAKEL--RRPPPRS--------------------------------------------------- -----------------------------------------------------------PQPAERVDPALP------LEK Q-------------------PWFHGPLNRADAES-----------LLSLCKEGSYLVRLS---------------ETSPQ DCSLSLRSSQG---------------------------FLHLKFARTRENQ----------------------------- -----VVLGQHSGPFPSVPELVLHYSS-------------------------RPLPVQGAEHLALLYPVVT----QTP-- ------------------------------------------------------------------ >Gorilla_gorilla_SHD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNL DFEDPYED-AENRLEPDPAG--------------------------PGDSKNPGDAKYGSPKHRLIKVEAAD-------- ---------------MARAKALLGGPGEE-------------LEADTEYS------------------DPFDAQPHP--- -------------APPDDGYMEPYDAQWVMS-------------------------------------ELPG-------- --------------------------------------RGVQLYDTPYEEQ------------DPETADGPPSG-----Q KPRQS-------------------------------RMPQEDERPADEYDQPWEWKKDH-ISRAFA-------------- ----------------------------------VQFDSPEWERTP---------------------------------- --------------GSAKEL--RRPPPRS--------------------------------------------------- -----------------------------------------------------------PQPAERVDPALP------LEK Q-------------------PWFHGPLNRADAES-----------LLSLCKEGSYLVRLS---------------ETSHQ DCSLSLRSSQG---------------------------FLHLKFARTRENQ----------------------------- -----VVLGQHSGPFPSVPELVLHYSS-------------------------RPLPVQGAEHLALLYPVVT----QTP-- ------------------------------------------------------------------ >Mus_musculus_SHD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------MAKWLRDYLNLGSRRPPPQPPTPDYTESDILRAYREQKDL DFEDPYED-SNGRAEPEVTG--------------------------------SGDPKYNSPRHRLIKVEAAD-------- ---------------MARAKALLGSPGEEQ------------PEAETEYS------------------DPFDAQPQP--- -------------PAPNSGYMEPYDARSVSS-------------------------------------EQPS-------- --------------------------------------RAVQLYDTPYEEQ------------ATKPEDGGSSG------ ---QS-------------------------------RRPLEDERPADEYDQPWEWKKDH-ISRAFA-------------- ----------------------------------VQFDGPDWERTP---------------------------------- --------------CSTKEP--WRP------------------------------------------------------- ------------------------------------------------------------QPAERVDTALA------LEK Q-------------------PWFHGPLSRAEAEN-----------LLSLCKEGSYLVRLS---------------ETRAQ DCILSLRSNQG---------------------------SMHLKFARTRENQ----------------------------- -----VVLGQHSGPFPSIPELVLHYSA-------------------------RPLPVQGAEHLALLYPVTSSQSSQGPCT LAAKPERGQGDP------------------------------------------------------ >Rattus_norvegicus_SHD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------MAKWLRDYLNLGSRRPPPQPPTPDYTESDILRAYREQKDL DFEDPYED-SNGRPESEITE--------------------------------SSDPKYNSPRHRLIKVEAVN-------- ---------------LARAKTLLGSLGEE-------------PEADTEYS------------------DPFDAQPQP--- -------------PAPNNGYMEPYDARNISS-------------------------------------EQPS-------- --------------------------------------RAVQLYDTPYEEQ------------DMKPEDGGSSG------ ---QS-------------------------------RRPLEDERPADEYDQPWEWKKDH-ISRAFA-------------- ----------------------------------VQFHGPDWERTP---------------------------------- --------------CSTKEP--WRP------------------------------------------------------- ------------------------------------------------------------QPAERVDTALA------LEK Q-------------------PWFHGPLSRVEAEN-----------LLSLCKEGSYLVRLS---------------ETRAQ DCILSLRSNQG---------------------------SMHLKFAKTRENQ----------------------------- -----VVLGQHSGPFPSVPELVLHYSA-------------------------RPLPVQGIEHLALLYPVTSSQSSQGPCT LAARPEKGQGDP------------------------------------------------------ >Canis_familiaris_SHD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------SFGVTHAQMAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYREQKDL DFEDPYED-SDSRLEPDPAG--------------------------PGDCKGPGDAKYDSPKHRLIKVEAAD-------- ---------------MARD--LSHSPSEP------------WSTLNHDAPPGVPQG-CVGQCLG---GQRKEGGPHP--- -------------PPSDDGYMEPYDAQR--A-------------------------------------DLPC-------- --------------------------------------KGVQLYDTPYEEQ------------DQDPGDGAPSG-----R RPRQS-------------------------------RLPQEDERPADEYDQPWEWKKDH-ISKAFAGAPPPQALTLPPQA LSVH-------------------------VLPLSALFDSPEWERTP---------------------------------- --------------GSAKEL--RRPPSRS--------------------------------------------------- -----------------------------------------------------------PQAAERVDPALP------LEK Q-------------------PWFHGPLSRADAEN-----------LLSLCKAGSYLVRLS---------------ETSPQ DCSLSLRSSQG---------------------------FLHLKFARTRESQ----------------------------- -----FVLGQHSGPFASVPELVLHYSS-------------------------RPLPVQGAEHLALLYPVVT----QTP-- ------------------------------------------------------------------ >Equus_caballus_SHD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------MEPYDAQWVVS-------------------------------------ELPC-------- --------------------------------------RGVQLYDTPYEEQ------------DREPGDGPPSG-----R RPRQS-------------------------------RLPPEDERPADEYDQPWEWKKDH-ISKAFA-------------- ----------------------------------VQFDSPEWERTS---------------------------------- --------------GSAKEL--RRPPPRS--------------------------------------------------- -----------------------------------------------------------PQPAERVDAALP------LEK QPRNPRGLPWSDPACPRPQGVWFHGPLSRADAES-----------LLSLCKEGSYLVRLS---------------ETSPQ DCSLSLRSSQG---------------------------FLHLKFARTRENQ----------------------------- -----FVLGQHSGPFASVSELVLHYSS-------------------------RPLPVQGAEHLALLYPVGT----QTP-- ------------------------------------------------------------------ >Loxodonta_africana_SHD -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------MAKWLRDYLSFGGRRPPPQPPTPDYSESDILRAYRAQKNL DFEDPYED-ADSRLEPDPAG--------------------------TGDPKGPGDTKYDSPKHRLIKVEAAD-------- ---------------MAKAKALLGSPGEE-------------PEADTEYS------------------DPFDAQPHL--- -------------PPPDDGYMEPYDAQRVVS-------------------------------------ELPG-------- --------------------------------------RGVQLYDTPYEEE------------DQEPGDEPPSGG----Q KPRQS-------------------------------RLPQEDERPADEYDQPWEWKKDH-ISRAFA-------------- ----------------------------------VQFDSPDWERTP---------------------------------- --------------GLAKEL--RRPLPRS--------------------------------------------------- -----------------------------------------------------------PQPAERVDPTLP------LEK QPI-----------------PWFLGESHMASVPPPP--------ASSSLCLSCFLILRSE---------------HXSPQ DCSLSLRSSQG---------------------------FLHLK------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------ >Tetraodon_nigroviridis_SHD_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------MAKWLK--LNFGSKRDPPQPPRPDYTESEILRAYRAQKEL DFEDPYQH-TDKEHQNGGFSPALSLPSFPA---------------FGSVLPNGMEVKVVSPKHRLIKVDSQE-------- ---------------FGRCKVPLSPTAVQEEPVIP--SAPSALEGDADYS------------------DPFDVRPDPRGR PHWETK-----PASTDCCSYMEPFEAQRILS-------------------------------------EMQHSKKTN--- --------------------------------RSGSGDG-GQLYDNPYEERTRQPRQAAPPAQQAH-WVEAARVQ----V DSRES-------------------------------RLPQDDERPADEYDQPWEWKKDD-ISKALA-------------- ----------------------------------VQFEGAERERSWAQTEQTRFS------------------------- ------KAGNATSSVDSTTL--RLVGDTPP-------------------------------------------------- ------------------------------------------------------------RLGERVDPSVP------LER Q-------------------VWYHGTLSRSEAEG-----------LLTLCKESSYLVRNS---------------QTGRN DYSLSLRSCKG---------------------------FMHMKFSLSADGR----------------------------- -----YVLGENSPPFGTIPEVIHYYTT-------------------------HKLPIRGAEHMSLLYPVIV----QTL-- ------------------------------------------------------------------ >Gasterosteus_aculeatus_SHD_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------MAKWLKDYLNFGTRRDPPQPPRPDYSESEILRAYRAQKEL DFEDPYQH-SEKEHQNGGFS------------------------------PRSATVKVVSPKHRLIKVDSQE-------- ---------------LVRCLLLLCP-------------QQAALDADTDYS------------------DPFDVCPEPRGR QNWEPK-----PASTDYCSYMEPFEAQRIIS-------------------------------------GLLS-------- ----------------------------------GSADG-VQLYDNPYEERPRPYYRAAPAAQQQTPRVELG--L----P DSRES-------------------------------RLPRDDERPADEYDQPWEWKKDN-ISKALAAI------------ ----------------------------------VQFEGAERER------------------------------------ ------------SRVDSTTF--PLIGDTPP-------------------------------------------------- ------------------------------------------------------------LLGERVDPTMP------LER Q-------------------VWYHGALSRSEAES-----------LLTLCKESSYLVRNS---------------QTCRN DYSLSLRSCKG---------------------------FMHMKFTRSAERR----------------------------- -----YVLGENSPPFSTIPEVIHYYTT-------------------------HRLPIRGAEHMSLLYPVIV----QTL-- ------------------------------------------------------------------ >Homo_sapiens_SHE 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----------------------------MQWSPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKW-FKEFPLNLKT VSERAKPGGGGG-----------------KLRKN---------SEAGGAGPGP----GKGRKNSAAELGSGRAGV---GP KDSRLSRDSLQGLIQAAAGKGRKNSRAT-------------EEEPHRGAT-KSSGCSTYINRLIKVDTQEKNGKSNYP-- ----SSSSSSSSSSSS---ASSSPSSLGPELDKGKIIKQQETVIILEDYA------------------DPYDAKRTKGQR DAER---------VGENDGYMEPYDAQQMIT-------------------------------------EIRRRGSKDPLV KALQLLDSPCEPADGGLK-----SETLAKRRSSKDLLGKPPQLYDTPYEP--------------AEGGP-RAEG------ KARPPD-----------------------------SRLPENDERPAAEYEQPWEWKKEQIVRALS--------------- ----------------------------------VQFEGAERPSFREETVRQ---------------------------- -------------HHRQKSWTQKILKPALSDHS----------------------------------------------- -------------------------------------------------------------EGEKVDPGLP------LEK QP-------------------WYHGAISRAEAES-----------RLQPCKEAGYLVRNS---------------ESGNS RYSIALKTSQG---------------------------CVHIIVAQTKDNK----------------------------- -----YTLNQTSAVFDSIPEVVHYYSN-------------------------EKLPFKGAEHMTLLYPVHSKLH------ ------------------------------------------------------------------ >Pan_troglodytes_SHE -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MQWSPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKW-FKEFPLNLKT VSERAKPGGGGG-----------------KLRKN---------SEAGGAGPGP----GKGRKNSAAELGSGRAGV---GP KDSR---------------------------------------------------------------------------- ---------------------SSPSSLGPELDKGKIIKQQDTVIILEDYA------------------DPYDAKRTKGQR DAER---------VGENDGYMEPYDAQQMIT-------------------------------------EIRRRGSKDPLV KALQLLDSPCEPADGGLK-----SETLAKRRSSKDLLGKPPQLYDTPYEP--------------AEGGP-RAEG------ KARPPD-----------------------------SRLPENDERPAAEYEQPWEWKKEQIVRALS--------------- ----------------------------------VQFEGAERPSLREETVRQ---------------------------- -------------HHRQKSWTQKILKPALSDHS----------------------------------------------- -------------------------------------------------------------EGEKVDPGLP------LEK QP-------------------WYHGAISRAEAES-----------RLQPCKEAGYLVRNS---------------ESGNS RYSIALKTSQG---------------------------CVHIIVAQTKDNK----------------------------- -----YTLNQTSAVFDSIPEVVHYYSN-------------------------EKLPFKGAEHMTLLYPVHSKLH------ ------------------------------------------------------------------ >Gorilla_gorilla_SHE -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MQWSPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKW-FKEFPLNLKT VSERAKPGGGGG-----------------KLRKN---------SEAGGAGPGP----GKGRKNSAAELGSGRAGV---GP KDSRLSRDSLQGLIQAAAGKGRKNSRAT-------------EEEPHRGAT-KSSGCSTYINRLIKVDTQEKNGKSSYP-- ----SSSSSSSSSSSS---ASSSPSSLGPELDKGKIIKQQDTVIILEDYA------------------DPYDAKRTKGQR DAER---------VGENDGYMEPYDAQQMIT-------------------------------------EIRRRGSKDPLV KALQLLDSPCEPADGGLK-----SETLAKRRSSKDLLGKPPQLYDTPYEP--------------AEGGP-RAEG------ KARPPD-----------------------------SRLPENDERPAAEYEQPWEWKKEQIVRALS--------------- ----------------------------------VQFEGAERPSVREETVRQ---------------------------- -------------HHRQKSWTQKILKPALSDHS----------------------------------------------- -------------------------------------------------------------EGEKVDPGLP------LEK QP-------------------WYHGAISRAEAES-----------RLQPCKEAGYLVRNS---------------ESGNS RYSIALKTSQG---------------------------CVHIIVAQTKDNK----------------------------- -----YTLNQTSAVFDSIPEVVHYYSN-------------------------EKLPFKGAEHMTLLYPVHSKLH------ ------------------------------------------------------------------ >Pongo_abelii_SHE -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MQWPPTPGASACLGWASSLACSTAATLLGRAGRGPLMAAKW-FKEFPLNLKT VSERAKPGGGGGG----------------KLRKN---------SEAGGAGPGP----GKGRKNSAAELGSGRAGV---GP KDSRLSRDSLQGLIQAAAGKGRKNSRAT-------------EEEPHRGAT-KSSGCSTYINRLIKVDTQEKNGKSNYP-- ----SSSSSNSSSSSS---ASSSPSSLGPELDKGKIIKQQDTVIILEDYA------------------DPYDAKRTKGQR DAER---------VGENDGYMEPYDAQQMIT-------------------------------------EIRRRGSKDPLV KALQLLDSPCEPADGGLK-----SETLAKRRSSKDLLGKPPQLYDTPYEP--------------AEGGP-RAEG------ KARPPD-----------------------------SRLPENDERPAAEYEQPWEWKKEQIVRALS--------------- ----------------------------------VQFEGAERPSVREETVRQ---------------------------- -------------HHRQKSWTQKILKPALSDHS----------------------------------------------- -------------------------------------------------------------EGGKVDPGLP------LEK QP-------------------WYHGAISRAEAES-----------RLQPCKEAGYLVRNS---------------ESGNS RYSIALKTSQG---------------------------CVHIIVAQTKDNK----------------------------- -----YTLNQTSAVFDSIPEVVHYYSN-------------------------EKLPFKGAEHMTLLYPVHSKLH------ ------------------------------------------------------------------ >Mus_musculus_SHE -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MRRPPAPGAPRCLSWASSLFCSAASTLP-----GPLMAAKW-FKEFPLTLKT ASERARPGGAGG-----------------KPRKN---------SETGGAAPTP----GKGRKNSAAELGASKASSG--PP KDSRLSRDSLQGLIQAAAGKGRKNSRVT---------ATATEEEPHRGAVTKSAGCSTYISRLIKVDTQEKNGKSAYP-- -----GGGSTSSSSSSSSSASSSPSSLGPELDKAKIMRQQDTVIILEDYA------------------DPYDAKRTKGQR DAER---------VGENDGYMEPYDAQQMIT-------------------------------------EIRRRGSKDPLV KALQLLDGPSEPGE-TVK-----VEATAKRRSSKDLLGKPPQLYDTPYEP--------------SEGGQRVAEV------ KTRPAD-----------------------------SRLPEEDDRPAAEYEQPWEWKREQIARALS--------------- ----------------------------------VQFEGSDRPPGREDAGRP---------------------------- -------------HHWQK-----TLKPTLSDHG----------------------------------------------- -------------------------------------------------------------DGEKVDPGLA------LEK QP-------------------WYHGSISRAEAES-----------RLQPCKEAAYLVRNS---------------ESGNS KYSIALKTSQG---------------------------CVHIIVAQTKDNK----------------------------- -----YTLNQTSAVFDSIPEVVHYYSN-------------------------AKLPFKGAEHMTLLHPVH-KLH------ ------------------------------------------------------------------ >Rattus_norvegicus_SHE -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------MAAKW-FKEFPLTLKT ASERARPGGAGG-----------------KPRKN---------SETGSAAPTP----GKGRKNSAAELGGSRTGSG--PP KDSRLSRDSLQGLIQAAAGKGRKNSRVTTTATASAS-ATTTEEEPHRGAVAKSAGCSTYISRLIKVDTQEKNGKSIYP-- -----GGGSTSSSSSSSSSASSSPSSLGPELDKTKIMRQQDTVIILEDYA------------------DPYDAKRTKGQR DAER---------VGENDGYMEPYDAQQMIT-------------------------------------EIRRRGSKDPLV KALQLLDGPCEPGE-TMK-----VEATAKRRSSKDLLGKPPQLYDTPYEP--------------SEGDLRAAEV------ KARPAD-----------------------------GRLPEEDDRPAAEYEQPWEWKREQIARALS--------------- ----------------------------------VQFEGSDRSPGREEAGRP---------------------------- -------------QHWQK-----TLKPTLSDHG----------------------------------------------- -------------------------------------------------------------DGEKVDPGLA------LEK QP-------------------WYHGSISRAEAES-----------RLQPCKEAGYLVRNS---------------ESGNS KYSIALKTSQG---------------------------CVHIIVAQTKDSR----------------------------- -----YTLNQTSAVFDSIPEVVHYYST-------------------------AKLPFKGAEHMTLLHPVH-KLH------ ------------------------------------------------------------------ >Canis_familiaris_SHE 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