>Homo_sapiens_MTF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MRDSTGAGNSLVHKRSP LRRNQKTPTSLTKLSLQDGH-KAKKPACKFEEGQDVLARWSDG-LFYLGTIKK------------INILKQSCFIIFEDS SKSWVLWKDIQTG----------ATGSGEMVCTICQEEYSE------------------------APNEMVICDKCGQG- ---------------------YHQLCHTPHIDSSVIDSDEK------------------------------------WLC RQCVF---------------------------ATTTKRGGALKKGPNAK------------------------------- -----ALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEAC-VQCLQKPMLFGDR---- --------------------------FYTFICSVCSSGPEYLKRLPLQWV-DIAHLCLYNLSVIHKKKYFDSELELMTYI NENWDRLHPGELADTPKSERY---------------EHVLEALNDYKTMFMSGKE-IKKKKHLFG-----LRIRVPP--V PPNVAFKAEKEPEGTSHEFKIKGRKASKP--------------------------------ISDSREVSNGIEKKGKKK- SVGRPPGPYTRKMIQKTAEP-------------------------------------------LLDKESIS--ENPTLDL PCSIGR----------TEGTAHSSNTSDVDFTGASSAKETTSSSISRHYG------------------------------ -------------------------------------------------------------------------------- ---------LSDSRKRTRTGRSWPAAIPHLRRRRGRLPRRALQTQNSEIVKDDEGKEDYQFDELNTEILNN--------- -------------------------------------LADQELQLNHLKNSITSYFG-AAGRIACGEKYRVLARR----- ------------------------------VTLDGKVQYLVEWEGATAS------------------------------- --------------------------------------------- >Macaca_mulatta_MTF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------RDSTGAGNSLVHKRSP LRRNQKTPTSLTKLSLQDGH-KAKKPACKFEEGQDVLARWSDG-LFYLGTIKK------------INILKQSCFIIFEDS SKSWVLWKDIQTGS---------ATGSGEMVCTICQEEYSK------------------------APNEMVICDKCGQG- ---------------------YHQLCHTPHIDSSVIDSDEK------------------------------------WLC RQCVF---------------------------ATTTKRGGALKKGPNAK------------------------------- -----ALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEAC-VQCLQKPMLFGDR---- --------------------------FYTFICSVCSSGPEYLKRLPLQWV-DIAHLCLYNLSVIHKKKYFDSELELMTYI NENWDRLHPGELADTPKSERY---------------EHVLEALNDYKTMFMSGKE-IKKKKHLFG-----LRIRVPP--V PPNVAFKAEKEPEGTSHEFKIKGRKASKP--------------------------------ISDSREVSNGIEKKGKKK- SVGRPPGPYTRKMIQKTAEP-------------------------------------------LLDKESVS--ENPTLDL PCSIGR----------TEGTAHSSNTSDVDFTGASSAKETTSSSISRHYG------------------------------ -------------------------------------------------------------------------------- ---------LSDSRKRTRTGRSWPAAIPHLRRRRGRLPRRALQTQNSEIVKDDEGKEDYQFDELNTEILNN--------- -------------------------------------LADQELQLNHLKNSITSYFG-AAGRIACGEKYRVLARR----- ------------------------------VTLDGKVQYLVEWEGATAS------------------------------- --------------------------------------------- >Mus_musculus_MTF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MRDSTGAGNSLVHKRSP LRRNQKTSASLNKLSLQDGH-KAKKPACKFEEGQDVLARWSDG-LFYLGTIKK------------INILKQSCFIIFEDS SKSWVLWKDIQTG----------ATGSGEMVCTICQEEYSE------------------------APNEMVICDKCGQG- ---------------------YHQLCHTPHIDSSVIDSDEK------------------------------------WLC RQCVF---------------------------ATTTKRGGALKKGPNAK------------------------------- -----ALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEAC-VQCLQKPMLFGDR---- --------------------------FYTFICSVCSSGPEYLKRLPLQWV-DIAHLCLYNLSVIHKKKYFDSELELMTYI NENWDRLHPGELADTPKSERY---------------EHVLEALNDYKTMFMSGKE-IKKKKHLFG-----LRIRVPP--V PPNVAFKAEKEPEGTSHEFKIKGRKASKP--------------------------------TSDSREVSNGIEKKGKKK- SVGRPPGPYTRKMIQKTAEL-------------------------------------------PLDKESVS--ENPTLDL PCSIGR----------TEGIAHSSNTSDVDLTGASSANETTSASISRHCG------------------------------ -------------------------------------------------------------------------------- ---------LSDSRKRTRTGRSWPAAIPHLRRRRGRLPRRALQTQNSEVVKDDEGKEDYQFEELNTEILNN--------- -------------------------------------LADQELQLNHLKNSITSYFG-AAGRIACGEKYRVLARR----- ------------------------------VTLDGKVQYLVEWEGATAS------------------------------- --------------------------------------------- >Felis_catus_MTF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MRDSTGAGNSLVHKRSP LRRNQKTPTSLTKLSLQDGH-KVKKPACKFEEGQDVLARWSDG-LFYLGTIKK------------INILKQSCFIIFEDS SKSWVLWKDIQTG----------ATGSGEMVCTICQEEYSE------------------------APNEMVICDKCGQG- ---------------------YHQLCHTPHIDSSVIDSDEK------------------------------------WLC RQCVF---------------------------ATTTKRGGALKKGPNAK------------------------------- -----ALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEAC-VQCLQKPMLFGDR---- --------------------------FYTFICSVCSSGPEYLKRLPLQWV-DIAHLCLYNLSVIHKKKYFDSELELMTYI NENWDRLHPGELADTPKSERY---------------EHVLEALNDYKTMFMSGKE-IKKKKHLFG-----LRIRVPP--V PPNVAFKAEKEPEGTSHEFKIKGRKASKP--------------------------------ISDSREVSNGIEKKGKKK- SVGRPPGPYTRKMIQKTAEP-------------------------------------------PLDKESIS--ENPTLDL PCSIGR----------TEGTAHSSNTSDVDFTGASSTKETTSSSISRHYG------------------------------ -------------------------------------------------------------------------------- ---------LSDSRKRTRTGRSWPAAIPHLRRRRGRLPRRALQTQNSEIVKDDEGKEDYQFDELNTEILNN--------- -------------------------------------LADQELQLNHLKNSITSYFG-AAGRIACGEKYRVLARR----- ------------------------------VTLDGKVQYLVEWEGATAS------------------------------- --------------------------------------------- >Monodelphis_domestica_MTF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------MVCTICQEEYSE------------------------APNEMVICDKCGQG- ---------------------YHQLCHTPNIDSSVIDSDEK------------------------------------WLC RQCVF---------------------------ATTTKRGGALKKGPNAK------------------------------- -----ALQVMKQTLPYSVADLEWDPGHKTNAQQCYCYCGGPGDWYLKMLQCCKCKQWFHEAC-VQCLQKPMLFGDR---- --------------------------FYTFICSVCSSGPEYLKRLPLQWV-DIAHLCLYNLSVIHKKKYFDSELELMTYI NENWDRLHPGELADTPKSERY---------------EHVLEALNDYKTMFMSGKE-IKKKKHLFG-----LRIRVPP--V PPNVAFKAEKEPEGTSHEFKIKGRKASKP--------------------------------IPDPRDISNGIEKKGKKK- SVGRPPGPYTRKMIQKTSEPS------------------------------------------SLEKESVP--ENPTLDL PSSLGK----------PDGTAHSSNTSDVDLTGAASTKETTSSTISRHYG------------------------------ -------------------------------------------------------------------------------- ---------LSDSRKRTRTGRSWPAAIPHLRRRRGRLPRKALQTQNSEIVKDDEGKEDYQFDELNTEILNN--------- -------------------------------------LADQELQLNHLKNSITSYFG-AAGRIACGEKYRVLARR----- ------------------------------VTLDGKVQYLVEWEGATAS------------------------------- --------------------------------------------- >Gallus_gallus_MTF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------RDSTAVGNSLVHKRSP LRRSHKASASSPKLSLRDGQ-KAKKPLCKFEEGQDVLARWSDG-LFYLGTIKK------------INKLKQNCFIIFEDS SKSWVLWKDIQTGA----------TESGEMVCTICQEEYSE------------------------APNEMVICDKCGQG- ---------------------YHQLCHTPNIDSSVIDSDDK------------------------------------WLC RQCVF---------------------------ATTTKRGGALKKGPNAK------------------------------- -----ALQVMKQTLPYNATDLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEAC-VQCLQKPMLFGDR---- --------------------------FYTFICSVCSSGPEYLKRLPLRWV-DIAHLCLYNLSVIHKKKYFDSELELMAYI NENWDRLHPGELADTPKSERY---------------EHVLEALNDYKTMFMSGKE-IKKKKHLFG-----LRIRVPP--V PPNAALKAEKEPEGTSHEFKIKGRKSSKP--------------------------------IPDVRELSNGIERKGKKK- SVGRPPGPYTRKMIHKTPESS------------------------------------------PLDTEPVPVIETPALEL PCSVGK----------SDGTAHSSNTSDVESTGAASIKETTSSSISRHYS------------------------------ -------------------------------------------------------------------------------- ---------LSDSRKRTRTGRTWPAAIPHLRRR-GRFPRKALQTQNSEIVKDDESKEDYQYDELNTEILNN--------- -------------------------------------LADQELQLNHLKNSITSYFG-AAGRIACGEKYRVLARR----- ------------------------------VTLDGKVQYLVEWEGATAS------------------------------- --------------------------------------------- >Anolis_carolinensis_MTF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MRDSTGVGNSVVHKRSP LRRNQKPPISLTKLSSRDGQ-KAKKPVCKFEEGQDVLARWSDG-LFYLGTIKK------------INKLKQTCFVIFEDS SKSWVLWKDIQTGA----------TESGEMVCTICQEEYSE------------------------APNEIVICDKCGQG- ---------------------YHQLCHTPNIDSSVIDSDDK------------------------------------WLC RQCVF---------------------------ATTTKRGGALKKGPNAK------------------------------- -----ALQVMKQTLPYSVADLEWDAGHKTNAQQCYCYCGGPGDWYLKMLQCCKCKQWFHEAC-VQCLQKPMLYGDR---- --------------------------FYTFICSVCSSGPEYLKRLPLQWV-DIAHLCLYNLSVIHKKKYFDSELELMTYI NENWERLHPGELADTPKSERY---------------QHVLEALNDYKTMFMSGKE-IKKKKHLFG-----LRIRVPP--C PPNATFKAEKEPEGTSHEFKIKGRKSSKP--------------------------------VPDQREITNGVEKKGKKK- SVGRPPGPYTRKMIQKMSEP--------------------------------------------IPLEPVVVQESPTLDL PSTTGR----------SDGTAHSSNTSDVESTGAASTKETTSNSTSKHYS------------------------------ -------------------------------------------------------------------------------- ---------LSDSRKRTRTGRTWPAAIPHLRRR-GRLPRKALQIQNSEIVKDDESKDDYQYDELNTEILNN--------- -------------------------------------LADQELQLNHLKNSITSYFG-AAGFILHSA------------- -------------------------------------------------------------------------------- --------------------------------------------- >Xenopus_tropicalis_MTF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MRDATVVGKSLVLKRST FRRHPKAVESLTKLCVRHGT-IPKRQICKFEEGQDVLARWSDG-LFYLGTIKK------------INKLRQSCFILFEDS SKSWVLWKDIQTG----------AIESEEMVCSICQEEYSD------------------------APNEIVICDKCGQG- ---------------------YHQLCHTPKIDPNVIETDEK------------------------------------WLC RQCVF---------------------------ASTTKRGGAPKKGPNAK------------------------------- -----ALQVMKQSLPYNLEDLEWDIGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEAC-VQCLEKPMLFGDR---- --------------------------FYTFICSVCNSGPEYLKRLSLRWV-DIAHLCLYNLSVIHKKKYFDSELELITYI NDNWDRIQPGELADTPRSERY---------------EHILDALNENKTMFMSGKE-IKKKKHLFG-----LRIRVPP--V PPNAAVKMEKE-ESTSHEFKIKGRKSSKV--------------------------------TPVTKEINNGEVK--KRK- PVGRPPGSHRRKILQNEPCETPSLA-------------------------------------NNMDTEPVS--ENSLLDT PEQRSRK---------PEVTNSSSSNSDLETSGAVSAKETTSSIVSSPQ------------------------------- -------------------------------------------------------------------------------- ----------PDFRRVTRTGRTWPASIPPQKKR-GRLPRRALQTHNSDLTKNDESKEDLQPAGLNTDIVKN--------- -------------------------------------LTEQDLQLNHLKNSITNYFG-AAGRIACGEKYRILARR----- ------------------------------VTLDGKVQYLVEWDGATAS------------------------------- --------------------------------------------- >Takifugu_rubripes_MTF2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------YRDSGVVDHLPVHHRAQ PQQQQQAVSLSPTSLAARGEYGEDDMSDKFTEGQDVLARWSDG-LFYLGTITK------------IDRDKHRCFVVFEDR SKSWVLWKDIQTGDEDDE-----DDEDDDLVCSICQDETSE------------------------EPNEIVICDKCGQG- ---------------------YHQLCHSPIIDASVIDCDDN------------------------------------WLC YECEL---------------------------TSLPKGGGVQRREGSAKGFL---------------------------K ---QEQPVDVHLSLPYALDELIWDQGHITNLQQCYCYCGGPGDWYLKMLQCNRCEQWFHEAC-LHCLQMPLLYGDR---- --------------------------FYLFICSVCNTGPEYIRRLTLSWV-DVTHLSLYNLSVIHKKKYFDSEMHLMTYI NDNWELLQLGELTNTPSSERY---------------KNVLEALNNNSNTFMSGKE-VKKKKHLFG-----LRIRLPP--A PPNSSEPASKLMERSLHEITIKGCKPTKTTLSG----------------------------SKTCNNLTNGTDKKKKKK- KKKRKPGPRSLEALAKRQRSA--EV-------------------------------------LTQETRK--PLENRTLDH LASVNS------PHLSARIDRSLLS-SDAESIGALSTTETTSTSISRQS------------------------------- -------------------------------------------------------------------------------- --------SLCSSSKTHTTASIMPISSPPLKRKRGR-PRRNLQSPNPGIPPPSHADPIPTTTEVLSPLTGL--------- ------------------------------NSTDIVHSMDPNSQLSHLKNSISNYFG-AAGRLACGEKYKVLARR----- ------------------------------VTLDGKVQYLVEWEGVTAS------------------------------- --------------------------------------------- >Tetraodon_nigroviridis_MTF2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------TETSGVVDHLPVHHRAH PQRQQQVVSLSPTSLAARGEYGEDHMSDKFTEGQDVLARWSDG-LFYLGTITK------------IDRDKQRCFVVFEDR SKSWVLWKDIQTGK----------DEEDDIVCSICQDETSE------------------------EPNEIVICDKCGQG- ---------------------YHQLCHSPIIDASVIDSDDK------------------------------------WLC YECEL---------------------------TSLPKRAGAQRRGGSAKGFL---------------------------K ---QEQPVEVHLSFPYALDELVWDQGHITNMQQCYCYCGGPGDWYLKMLQCNRCEQWFHEAC-LHCLQMPLLYGDR---- --------------------------FYLFICSVCNAGPEYLTRLPLSWV-DVTHLSLYNLSVIHKKKYFDSEMHLMTYI NDNWELLQLGELTNTPRSERY---------------ENVLEALNNNSNMFMSGKE-VKKKKHLFG-----LRIRFPP--A PPNSSEQASQLMERPLHEITIKGCKSTKT-LSG----------------------------SKTCNTLTNGTDKKKKKK- KN-RKPGPRSLETLAKRQRSS--EV-------------------------------------LTQDMRK--PLENRTLDH LPSVK---------LSTRIDRSLLS-SDAESIGALSTTETTSTSISRQS------------------------------- -------------------------------------------------------------------------------- --------SLCSSSKMHTSASIVPISSPPLKRKRGR-PRRNVQVSSAQIPPPSHADPIPTTTEVLSPLP----------- --------------------------------------MDPSSQLSHLKNSISSYFG-AAGRLACGEKYKVLARR----- ------------------------------VTLDGKVQYLVEWEGVTAS------------------------------- --------------------------------------------- >Gasterosteus_aculeatus_MTF2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MRVSGDVDHLSVHHRAL PQRQQQAVSGSPTSLSARGEYGEDSMSDRFTEGQDVLARWSDG-LFYLGTITK------------INREKQQCFVVFEDR SKSWVLWKDIQTGN---F-----FNFNIYIVCSICQDETSD------------------------EPNEIVICDKCGKG- ---------------------YHQLCHSPTIDASVIDSDDK------------------------------------WLC SDCEL---------------------------TCRPKREAANMRGASAQGFV---------------------------E QELQEKHTGLHLSLPYALDELVWDQAHETNIQQCYCYCGGPGDWYLKMLQCNGCLQWFHEAC-LHCLQIPMFYGDR---- --------------------------FYLFICSVCNGGPEYLSRLPLTWE-NVTHLSLYNLSVIHKKMYFDSEMLLMSYI NDNWELLQLGELGNTPRSQRY---------------GRVLEALNNNSSIFKSGKE-VKKKKHLFS-----LRIRFPP--A PPNSHEPSGRGMDRTSHEINIKGCKSTKT--------------------------------PPGMMSLTNGTEKKKK--- ---RKQGARSLETLAKPQCS---ER-------------------------------------LSQNLRRPLPLEPNTLDH LTAAKLKCVIYFEFTFTRRERPQLSTSDVESIGALSTTETTSTSISRPSRR----------------------------- -------------------------------------------------------------------------------- --------TSCSSSKTRTTACIMPVSAPLLKRKRGR-PRRAPQPPRPEILPPSHADPNPSATEMMSPLPRL--------- ------------------------------HSADIVHGMDPNSQLSHLKSSISSYFG-AAGRLACGEKYKVLARR----- ------------------------------VTLDGKVQYLVEWEGVTAS------------------------------- --------------------------------------------- >Oryzias_latipes_MTF2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MRDSGVADHLLVQHTSH LHRQG--APLLPSSLSVREEYGEEGMSARFREGQDVLARWSDG-LFYLGTITK------------IDEEKQRCFIVFEDQ SKSWVFWKDIQTGDEDDE-----DEEDEDIVCSICQEEVSE------------------------EPNEIVICDNCGQG- ---------------------YHQLCHDPVIDAAVIDSDDE------------------------------------WLC SDCEH---------------------------ASLSKRRASATKHDAEA------------------------------- ----QQHTELQLSFPYALDKLVWDQGHKTNLQQCYCYCGDPGDWYLKMLQCKQCQQWFHEAC-LHCLPMPMLYGDR---- --------------------------FYLFICSVCNGGPEFVSRLPLSWK-DVAHLSLYNMSVIHKKKYFDSENHLLEYI NDNWELLQPGELADTPIAERC---------------ENVLKALNSNSCIFKSGKE-VKKKKHLFS-----LRVCFPP--S PPHSNEPANGLMDKTSHEIAVKGCKPTTT--------------------------------LSGMGHRHAGFHDKTFLG- ---RPESHHAMINSSSETAAV--PH-------------------------------------LFAGLQKSFCLEQESLLD TDQTQG--------SGPKKSQLSSQTLEVESIGDLSVSETTSTSISRQS------------------------------- -------------------------------------------------------------------------------- --------SLCSS-LMHRPAYGMPASSPPLKRKRGR-PRRALQPPHPEIPPPGPADANPPASERL-HLPGL--------- ------------------------------HSSNIVHGLDPDSQLSHLRSSISSYFG-AAGRLACGEKYKVIARR----- ------------------------------VTFDGKVQYLVEWEGVTAS------------------------------- --------------------------------------------- >Strongylocentrotus_purpuratus_MTF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MASSTQVSSDLA SCSYQLSPNNKPSKSTSNQSDETTDRPKPQSSPKRPIRDAVAAAKLNSALLPAKVTRIGASPKRLKKEGSWRGDESATKK QSPTKSDASEDQDQSPNTSSSGETFKDAEYSEGLDVLARWSDG-LFYLGTVKE------------VEQEHERCMVSFEDE SEFWVLYKDLQKAHNQNE--------DQDITCFVCNDGMSD------------------------FPNEIVICDRCGRG- ---------------------YHQQCHSPSIEGSILQNEDE-----------------------------------PWHC RPCVF---------------------------VNSVKVGGALKKGPAAKV------------------------------ ------FQEFKKTLPYKIETIHWDAGHKTNTEQYYCYCGGPGDWYLKMLQCCRCRQWFHEAC-VQCIEIPMLYGDR---- --------------------------FYIFVCSVCNQGPEYLKRLPLKWG-DLAQLVLYNLTLLHKKKYYDFEEEILPNL TQNWNNYQVPHLSETTRSEKQ---------------ERMLNALQSSKMRFVCGKE-VKKKKNLWG-----LRVRTPP-VS PTIVLPAIGQITDDVMNDMKMTGTKVVTFQPVQ----------------------------SLSPVPLERRRRKQKGLTP EEIMANSKKARKLLLQATSSKTGRP-------------------------------------LTSLNQSYRGYGGGMCTS STGLTVVTGGCSVLDMIPPLEMVPLGNNVVPCSMTLSSRTSISSNGSSQNG----------------------------- -------------------------------------------------------------------------------- --------AGPSNGPMNQYGRLLSEQSMGKKRRGRKRKRRLSSEDLDNETSNGSQTPEEVKDTTDLEIKLKNQQ------ ----------------------------SPSKTRVN-GITEAASPIGILQSVTSYFG-AEGRIACGEGHKVLGKR----- ------------------------------VCADGKVQYLIQWEGSSP-------------------------------- --------------------------------------------- >Ciona_savignyi_MTF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------RKLCG------VFKEGHDVLVRWSDG-LYYLGTVFK------------VT-------FIFEDK SMFWAQFKDLQMINNKDGS---DNGVDSDVTCSICHDGVSD------------------------PPNEIVLCDKCGQG- ---------------------YHQLCHIPAIDTSILNDEDT-----------------------------------PWQC RTCVF---------------------------AAVAKRGGAESDGPAAAT------------------------------ ------LRVYKQVLPYDLKSLTWDKGHKVNHEELYCYCGGPGDWYLKMLQCCRCQQWFHEAC-MQCLETPFLYGDR---- --------------------------FFLFICSICNHGSEYVKRLPMRWV-DVVHLVLYNITIAKLVKYYDFQSTMMPFF VQNWEELQLGDVGSSTRSQLK---------------ERVLETLQNNKSRFQCGSE-SKKAK------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------- >Homo_sapiens_PHF1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MAQPPRLSRSG ASSLWDPASPAPTSGPRP----------RLWEGQDVLARWTDG-LLYLGTIKK------------VDSAREVCLVQFEDD SQFLVLWKDISPAA----------LPGEELLCCVCRSETVV------------------------PGNRLVSCEKCRHA- ---------------------YHQDCHVPRAP-APGEGEGT----------------------------------S-WVC RQCVF---------------------------AIATKRGGALKKGPYARA------------------------------ ------MLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEAC-TQCLSKPLLYGDR---- --------------------------FYEFECCVCRGGPEKVRRLQLRWV-DVAHLVLYHLSVCCKKKYFDFDREILPFT SENWDSLLLGELSDTPKGERS---------------SRLLSALNSHKDRFISGRE-IKKRKCLFG-----LHARMPPPVE PPTGDGALTSFPSGQGPGGGVSRPLGKRRRPEP----------------------------EP-----LRRRQKGKVE-- --ELGPPSAVRNQPEPQEQRERAH---------------------------------------LQRALQASV-SPPSPSP NQSYQ----------------G-SSGYNFRPTDARCLPSSPIRMFASFHP------------------------------ -------------------------------------------------------------------------------- -----------SASTAGTSGDSGPPDRSPLELHIG-FPTDIPKSAPHSMTASSSSVSSPSPGLPRRSAP----------- -------------------------------------PSPLCRSLSPGTGGGVRG---GVGYLSRGDPVRVLARR----- ------------------------------VRPDGSVQYLVEWGGGGIF------------------------------- --------------------------------------------- >Macaca_mulatta_PHF1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MAQPPRLSRSG TSSLWDPASPAPTSGPRP----------RLWEGQDVLARWTDG-LLYLGTIKK------------VDSAREVCLVQFEDD SQFLVLWKDISPAA----------LPGEELLCCVCRSETVV------------------------PGNRLVSCEKCRHA- ---------------------YHQDCHVPRAP-APGEGEGT----------------------------------S-WVC RQCVF---------------------------AIATKRGGALKKGPYARA------------------------------ ------MLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEAC-TQCLSKPLLYGDR---- --------------------------FYEFECCVCRGGPEKVRRLQLRWV-DVAHLVLYHLSVCCKKKYFDFDREILPFT SENWDSLLLGELSDTPKGERS---------------SKLLSALNSHKDRFISGRE-IKKRKCLFG-----LHARMPPPVE PPTGDGALTSFPSGQGPGGGVSRPLGKRRRPEP----------------------------EP-----LRRRQKGKVE-- --ELGPPSAVRNQPEPREQRERAH---------------------------------------LQRALQASV-SPPSPSP NQTYQ----------------G-SSGYNFRPTDARCLPSSPIRMFASFHP------------------------------ -------------------------------------------------------------------------------- -----------SASTAGTSGDGEPPDRSPLELHIG-FPTDIPKNAPHSMTASSSSVSSPSPGLPRRSAP----------- -------------------------------------PSPLCRSLSPGTGGGVRG---GVGYLSRGDPVRVLARR----- ------------------------------VRPDGSVQYLVEWGGGGIF------------------------------- --------------------------------------------- >Mus_musculus_PHF1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MAQLPRLSRLG APSLWDPASPAPTSGPRP----------RLWEGQDVLARWTDG-LLYLGTIKK------------VDSAREVCLVQFEDD SQFLVLWKDISPAA----------LPGEELLCCVCRSETVV------------------------PGNRLVSCEKCRHA- ---------------------YHQDCHVPRAP-APGEGEGA----------------------------------S-WVC RQCVF---------------------------AIATKRGGALKKGPYARA------------------------------ ------MLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEAC-TQCLSKPLLYGDR---- --------------------------FYEFECCVCRGGPEKVRRLQLRWV-DVAHLVLYHLSVCCKKKYFDFDREILPFT SENWDSLLLGELSDTPKGERS---------------SQLLSALNSHKDRFISGRE-IKKRKCLFG-----LHARTPPPVE LLTGDGAPTSFPSGQGPGGGVSRPLGKRWRSEP----------------------------EP-----LRRRQKGKVE-- --ELGPPTAAHSRHGSRE----------------------------------------------QRALQASV-SPPPPSP NQSYE----------------G-SSGYNFRPTDARCLPSSPIRMFASFHP------------------------------ -------------------------------------------------------------------------------- -----------SASTAGTSGDSEPPDRSPLGLHIG-FPTDTPKSSPHSVTASSSSVPALTPGFSRHS-P----------- -------------------------------------PSPLCRSLSPGTGGGVRG---GVSYLSRGDPVRVLARR----- ------------------------------VRPDGSVQYLVEWGGGGIF------------------------------- --------------------------------------------- >Felis_catus_PHF1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------MLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEAC-TQCLSKPLLYGDR---- --------------------------FYEFECCVCRGGPEKVRRLQLRWV-DVAHLVLYHLSVCCKKKYFDFDREILPFT SENWDSLLLGELSDTPKGERS---------------SKLLSALNSHKDRFISGRE-IKKRKCLFG-----LHARIPPPVE PLTGDGAPT----RAGPWG----------RGLT----------------------------SP-----------GEAP-- --EAG-----------------------------------------------------------------------ARAP EEEAE----------------G-ENG------GAGATLSS---AQSARAP------------------------------ -------------------------------------------------------------------------------- -----------GAKGAGSSAEG---------------------------TAGLSVSTNPQP------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------- >Equus_caballus_PHF1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MAQPPRLSRSG APPLWDPASPAPTSGPRP----------RLWEGQDVLARWTDG-LLYLGTIKK------------VDSAREVCLVQFEDD SQFLVLWKDISPAA----------LPGEELLCCVCRSETVV------------------------PGNRLVSCEKCRHA- ---------------------YHQDCHVPRAP-APGEGEGT----------------------------------S-WVC RQCVF---------------------------AIATKRGGALKKGPYARA------------------------------ ------MLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEAC-TQCLSKPLLYGDR---- --------------------------FYEFECCVCRGGPEKVRRLQLRWV-DVAHLVLYHLSVCCKKKYFDFDREILPFT SENWDSLLLGELSDTPKGERS---------------SKLLSALNSHKDRFISGRE-IKKRKCLFG-----LHARIPPPVE PPTGDGAPTSFPSGQGPGGGVSRPLGKRRRPEP----------------------------EP-----LRRRQKGKME-- --ELGPPSAVRNQPEPQEQRERAR---------------------------------------LQRALQASV-SPPPPSP NQNYQ----------------G-SSGYNFRPTDARCLPSSPIRMFASFHP------------------------------ -------------------------------------------------------------------------------- -----------SASTAGTSGDGEPPDRSPLELHIG-FPTDIPKSAPHSMTASSSSVPASSPGLPRRSAP----------- -------------------------------------PSPLCRSLSPGTGGGVRG---GVGYLSRGDPVRVLARR----- ------------------------------VRPDGSVQYLVEWGGGGIF------------------------------- --------------------------------------------- >Xenopus_tropicalis_PHF1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MEGREPSTRPSR TTPASPRVTPALVKRPRFQTLA------RFWEGQDVLARWTDG-LLYLGIIKK------------VDSAQETCLVRFEDN SQFSVLWKDIFPPA----------VPGKEQLCCVCNSQTCT------------------------PDNKLVHCGKCKHA- ---------------------YHQECHVPSVP-CDTDCPG-----------------------------------SSWMC RQCVF---------------------------AVATKRGGALKKGPYARA------------------------------ ------MLHMKLSLPYQLKSLEWDQLHLTNKQQCYCYCGGPGEWNMKMLQCCRCLQWFHEAC-TQCLSKPLLYGDR---- --------------------------FYVFECSVCTRGPENAWRLPLAWV-DVSHLVLYHLSICCKKKYFDFEREILSFV NENWDSLLLGELTDTPRSERY---------------SHLLHALTAQKDRFISGKE-IKKKKCLFG-----LQTRVPPPAP QS---------TESQLSSLVGRMGITRRPTHRK----------------------------RTQSIEKQTGRERQKL--- -LPLGGSTLVKKSPLPQQLYSSTQE-------------------------------------VIQDMLKSSIITPNPFSS NQEYQG-------------YRG--SAYNFRRTGARCLQNPPIRMFASFHP------------------------------ -------------------------------------------------------------------------------- -----------SANTSGSVAAS----LQSRKTKLRLFINGMSSEVQDP-PLLGEMMETAGPAPASLSSP----------- ---------------------------------------QVTPSLPSSS-VSSEG---CAWLGSTEPGMRVLARR----- ------------------------------VTAQGAVQYLVEWGGGDVF------------------------------- --------------------------------------------- >Danio_rerio_PHF1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------EGEDVLARWSDG-LLYLGNVKR------------VDSVKQCCLIRFEDN SEFWVLRKDIHSFS-----------SGGEEVCCICDSP--P------------------------LKEPLVNCLKCRHG- ---------------------YHPEC--HTPSIEPEVDPNS------------------------------------WIC RQCVF---------------------------AVATKRGGALKRGRFARL------------------------------ ------MQIMKVRLPYQLSSLDWDPQHLTNQQQCYCYCAGPGEWNLKMLQCGSCGQWFHEAC-TQCLSKPLLYGDR---- --------------------------FYQFQCSVCSNGAESVQRLPMTWV-DLAHLVLYHLSLCCKRKYFDFDHEIMSFA NENWESLLLGTLSDTPRQDRC---------------QNLLNALNSHKDRFVSGKE-IKKKKCLFG-----LQVRAPP--- PLSSDQSPFIAEQPINITHRRSGEQWHRMCVNP----------------------------NVG------SLRHSKMQK- NQEVFTPASSHKMHSLHNIKSCPAG-------------------------------------VAADALDRVP-------C CRGYE----------------GSNLYNSRKPDEEMSLGSPPKRMFALYHP------------------------------ -------------------------------------------------------------------------------- -----------SYNASQDLSRALHHYSAEDPCGLP------------APCLPCSVSSAHAPAQRYESCP----------- --------------------------------------SLFLRDVPPFHSPVGMAAP-SSMGWAGGDAVRILARR----- ------------------------------VTADGKLQYLVEWGNVSVY------------------------------- --------------------------------------------- >Gasterosteus_aculeatus_PHF1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------EGDDVLARWSDG-LLYLGNVKRV-----------VDGVKQSCLVRFEDN SEFWVLRKDIHSCASV--------AAGVEEVCCICDAP--P------------------------LKEPLVNCLKCRHG- ---------------------YHAEC--HTPAIEPEADSDS------------------------------------WIC RQCVF---------------------------AVATKRGGALKRGRFARL------------------------------ ------MQFMKLRLPYQLSSLDWDPQHLTNQQQCYCYCAGPGEWNLKMLQCGSCGQWFHEAC-TQCLTKPLLYGDR---- --------------------------FYQFQCSVCTKGPETIQRLPMTWM-DLAHLVLYHLSLCCKRKYFDFDHEILSFT NENWDSLLLGALSDTPRQDRC---------------HNLLNALNSHKDRFVSGKE-IKKKKCLFG-----LQVRAPP--- PLTSDSSPL----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------- >Oryzias_latipes_PHF1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------EGDDVLARWSDG-LLYLGNVKR------------VDGVKQCCLVRFEDN SEFWVLRKDIHSFA-----------AGGEEVCCVCDAP--P------------------------LKEPLINCLKCRHG- ---------------------KHLEAGLLKRTIEPEADSDS------------------------------------WIC RQCVF---------------------------AVATKRGGALKRGRFARL------------------------------ ------MQFMKLRLPYQLSSLDWDPQHLTNQQQCYCYCAGPGEWNLKMVQCGSCGQWFHEAC-TQCLTKPLLYGDR---- --------------------------FYQFQCSVCTKGPETIQRLPMTWV-DLAHLVLYHLSLCCKRKYFDFDHEILSFT NENWDSLLLGALSDTPRQDRF---------------HNLLNALNSHKDRFVSGKE-IKKKKCLFG-----LQVRAPP--- PLTSDTSPL----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------- >Homo_sapiens_PHF19 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MENRALDPGT RDSYGATSHLPNKGALAKVKNNFKDLMSKLTEGQYVLCRWTDG-LYYLGKIKR------------VSSSKQSCLVTFEDN SKYWVLWKDIQHAG----------VPGEEPKCNICLGKTSG------------------------PLNEILICGKCGLG- ---------------------YHQQCHIPIAGSADQPLLTP------------------------------------WFC RRCIF---------------------------ALAVRKGGALKKGAIART------------------------------ ------LQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEAC-TQCLNEPMMFGDR---- --------------------------FYLFFCSVCNQGPEYIERLPLRWV-DVVHLALYNLGVQSKKKYFDFE-EILAFV NHHWELLQLGKLTSTPVTDRG---------------PHLLNALNSYKSRFLCGKE-IKKKKCIFR-----LRIRVPP--N PPGKLLPDKGLLPNE-NSASSELRKRGKS--------------------------------KPGLLPHEFQQQKRRVY-- --RRKRSKFLLEDAIPSSDFTSA----------------------------------------WSTNHHLASIFDFTLDE IQSLKS------------ASSGQTFFSDVDSTDAASTSGSASTSLSYDS------------------------------- -------------------------------------------------------------------------------- -----------RWTVGSRKRKLAAKAYMPLRAKRWAAELDGRCPSDSS--AEGASVPERPDEGIDSHTFES--------- -------------------------------------ISEDDSSLSHLKSSITNYFG-AAGRLACGEKYQVLARR----- ------------------------------VTPEGKVQYLVEWEGTTPY------------------------------- --------------------------------------------- >Macaca_mulatta_PHF19 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MENRALDPGT RDSYGATSHLPNKGALAKVKNNFRDLMSKLTEGQYVLCRWTDG-LYYLGKIKR------------VSSSKQSCLVTFEDN SKYWVLWKDIQHAG----------VPGEEPKCNICLGKTSG------------------------PLNEILICGKCGLG- ---------------------YHQQCHIPIAGSADQPLLTP------------------------------------WFC RRCIF---------------------------ALAVRKGGALKKGAIART------------------------------ ------LQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEAC-TQCLNEPMMFGDR---- --------------------------FYLFFCSVCNQGPEYIERLPLRWV-DVVHLALYNLGVQSKKKYFDFE-EILAFV NHHWELLQLGKLTSTPVTDRG---------------PHLLNALNSYKSRFLCGKE-IKKKKCIFR-----LRIRVPP--N PPGKLLPDKGLLPNE-NSASSELRKRGKS--------------------------------KPGLLPHEFQQQKRRVY-- --RRKRSKFLLEDAIPSSDFTSA----------------------------------------WSTNHHLASIFDFTLDE IQSLKS------------ASSGQTFFSDVDSTDAASTSGSASTSLSYDS------------------------------- -------------------------------------------------------------------------------- -----------RWTVGSRKRKLAAKAYMPLRAKRWAAELDGRCPSDSS--AEGASVPERPDEGIDSHTFES--------- -------------------------------------ISEDDSSLSHLKSSITNYFG-AAGRLACGEKYQVLARR----- ------------------------------VTPEGKVQYLVEWEGTTPY------------------------------- --------------------------------------------- >Mus_musculus_PHF19 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------METQALEPGT LEAFGATS--PNKGGLSKTKKNFKDLMSKVTEGQFVLCRWTDG-LYYLGKIKR------------VSSPKQSCLVTFEDN SKYWVLWKDIQHAG----------VPGEEPKCDVCMGKTSG------------------------PMNEILICGKCGLG- ---------------------YHQQCHIPIAVDANWPLLTH------------------------------------WFC RRCIF---------------------------ALAVRKGGALKKGAIAKT------------------------------ ------LQAVKMVLSYQPEELDWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEAC-TQCLSEPMVFGDR---- --------------------------FYLFFCSVCNQGPEYIERLPLRWV-DIVHLALYNLGVQSKKRYFDFE-EILAFV NHHWELLQLGKLTSTPMTERG---------------PHLLNALNSYKSRFLCGKE-IKKKKCIFR-----LRIRVPP--A PPGKLLPDRALMPSD-KGTSELLRKKGKS--------------------------------KPGLLPQEPQQQKRRVY-- --RRKRSKFLLEDAIPSSDFTSA----------------------------------------WSTDHHLASIFDFTLDE IQSLKS------------GSSGQTFFSDVDSTDAASTSGSASTSLSYDS------------------------------- -------------------------------------------------------------------------------- -----------RWTVGSRKRKLTAKVHRPLRAKQRAAELEGRCASDSN--AEGAVGPEQPDEGIDSHTLES--------- -------------------------------------ISGDDSSLSHLKSSITNYFG-AAGRLACGEKYRVLARR----- ------------------------------VTPEGKVQYLLEWEGTTPY------------------------------- --------------------------------------------- >Felis_catus_PHF19 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MENRALDPGA RDSYGATSHLPNKGALAKAKNNFKDLMSKLTEGQYVLCRWTDG-LYYLGKIKR------------VSSSKQSCLVTFEDN SKYWVLWKDIQHAG----------VPGEEPKCNICLGKTSG------------------------PLNEILICGKCGLG- ---------------------YHQQCHIPIAGSADRPLLTP------------------------------------WFC RRCIF---------------------------ALAVRKGGALKKGAIART------------------------------ ------LQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEAC-TQCLNEPMMFGDR---- --------------------------FYLFFCSVCNQGPEYIERLPLRWV-DVVHLALYNLGVQSKKKYFDFE-EILAFV NHHWELLQLGKLTSTPVTDRG---------------PHLLNALNSYKSRFLCGKE-IKKKKCIFR-----LRIRVPP--N PPGKLLPDKGLVPTE-SVASSELRKRGKS--------------------------------KPGLLPHEFQQQKRRVY-- --RRKRSKFLLEDAIPSSDFTSA----------------------------------------WSTNHHLASIFDFSLDE IQSLKS------------ASSGQTFFSDVDSTDAASTSGSASTSLSYDS------------------------------- -------------------------------------------------------------------------------- -----------RRTVGSRKRKLAAKAYVPLRAKRRAAEPGGRCPSDSS--AEGALGPERPDEGVDSHTFES--------- -------------------------------------ISEDDSSLSHLKSSITNYFG-AAGRLACGEKYQVLARR----- ------------------------------VTPEGKVQYLVEWEGTTPY------------------------------- --------------------------------------------- >Equus_caballus_PHF19 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------QCQWKLMENRALDPGT RDSYGATSHLPNKGVLAKAKNNFKDLMSKLTEGQYVLCRWTDG-LYYLGKIKR------------VSSSKQSCLVTFEDN SKYWVLWKDIQHAG----------VPGEEPKCNICLGKTSG------------------------PLNEILICGKCGLG- ---------------------YHQQCHIPIAGSADRPLLTP------------------------------------WFC RRCIF---------------------------ALAVRKGGALKKGAIART------------------------------ ------LQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEAC-TQCLNEPMMFGDR---- --------------------------FYLFFCSVCNQGPEYIERLPLRWV-DVVHLALYNLGVQSKKKYFDFE-EILAFV NHHWELLQLGKLTSTPVTDRG---------------PHLLNALNSYKSRFLCGKE-IKKKKCIFR-----LRIRVPP--N PPGKLLPDKGLVPTE-NGASSELRKKGKS--------------------------------KPGLLPHEFQQQKRRVY-- --RRKRSKFLLEDAIPSSDFTSA----------------------------------------WSTNHHLASIFDFTLDE IQSLKS------------ASSGQTFFSDVDSTDAASTSGSASTSLSYDS------------------------------- -------------------------------------------------------------------------------- -----------RRTVGSRKRKLAAKAYMPLRAKRRAAELGGRCPSDSS--AEGASGPERPDEGIDSHTFES--------- -------------------------------------ISEDDSSLSHLKSSITNYFG-AAGRLACGEKYQVLARR----- ------------------------------VTPEGKVQYLVEWEGTTPY------------------------------- --------------------------------------------- >Monodelphis_domestica_PHF19 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------KLMENLSLESEI QDDCGPPR---AAGAPTKSRNNFKDLMVKLTEGQYVLCRWTDG-LYYLGKIKR------------VSSSKQSCLVTFEDN SKYWVLWKDIQHAG----------VPGEEPKCNICLGKTSG------------------------PLNEILICGKCGLG- ---------------------YHQQCHIPTASSTEGPLLTP------------------------------------WFC RRCIF---------------------------ALAVRKGGALKKGAIAKTCK---------------------------H ------LVFPSILPLLSPPSLFQLIQETESRRLKLMWASSLPRWYLRMLQCYRCRQWFHEAC-TQCLNEPMMFGDRQV-- --------------------------FYVFFCSVCNQGPEYIKRLPLRWV-DVVHLALYNLGVQSKKKYFDFE-EILAFV NHHWDLLQLGKLTSTPVTERG---------------PHLLNALNSYKSRFLCGKE-IKKKKCIFR-----LRIRVPP--N PPGKLLPDKVVSLKENGGTSSDLQKRGKSKYQT----------------------------KHSSVPHE--QQKRRVV-- --RRKRSKFLLEDAIPSSDFTSA----------------------------------------WSTNHHLASIFDFTLDE IQSLKS------------ASSGQTFFSDVDSTDAASTSGSASTSLSYES------------------------------- -------------------------------------------------------------------------------- -----------RRTVGSRKRKLAAKAYTSLGAKRRATEPGGRCTSDSS--AEGGSGPERPDDGIDSHTFES--------- -------------------------------------ISEDDSSLSHLKSSITNYFG-AAGRLACGEKYQVLARR----- ------------------------------VTPEGKVQYLVEWEGTTPY------------------------------- --------------------------------------------- >Gallus_gallus_PHF19 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------MENETLNSIS RDVRGAAG---CRGSSCR----------ELSEGQYVLCRWTDG-LYYLGKIKR------------VSGSKQSCLVTFEDN SKYWVLWKDIQHAG----------VPGEEPKCNICLEKTSG------------------------PRNEILICGKCGLG- ---------------------YHQQCHVPVASSDEGPLGTP------------------------------------WFC RRCIF---------------------------ALAVRKGGALKKGAIAKT------------------------------ ------LQAVKMVLSYNPDLLEWDSPHRTNQQQCYCYCGGPGEWYLKMLQCYRCRQWFHEAC-TQCLSDPMMFGDR---- --------------------------FYVFFCSVCNQGPEYIKRLPLRWV-DVVHLALYNLGVQSKKKYFDFE-EILAFV NHHWDPLQLGKLTGTPVSERG---------------PHLLNALNSYKSRFLCGKE-IKKKKCIFR-----LRIRVPP--N PPSKVLPEKAP--GE--GSSCELKRRGKSRYVH----------------------------KDSLLPGQLQQQKRRAV-- --RWKRAKFLLEDAIPSSDFTSA----------------------------------------WSTNHHLASIFDFTLDE IQSLKS------------ASSGQTFLSDVDSTDAVSTSGSATTSLSCESS------------------------------ -------------------------------------------------------------------------------- -----------RRTVGSRKRKQTVLTPPSARPKRGGGAAGRQPAVGSPQGSEVTCGPERPDDGIDSHTFES--------- -------------------------------------ISEDDSSLSHLKSSISSYFG-AAGRLVCGEKYQVLARR----- ------------------------------VTLEGKVQYLVEWEGTTPY------------------------------- --------------------------------------------- >Anolis_carolinensis_PHF19 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------MEETANACLQP-- ----------------SMNQKGRQELMATLTEGQYVLCRWTDG-LYYLGKIKR------------VSGSKQSCLVTFEDN SKYWVLWKDIQHAG----------VPGEEPKCNICLGGTTG------------------------PLNDILICGKCGLG- ---------------------YHQQCHIPRVSGREDSLVSP------------------------------------WFC RRCVF---------------------------ALAVRNGGALKKGAIART------------------------------ ------LQRVKMVLSYDPEQLEWDSLHRTNHQQCYCYCGGPGEWYLKMLQCCRCRQWFHEAC-TQCLSDPMLFGDR---- --------------------------FYIFYCSVCNQGPEYIKRLPLRWV-DLVHLVLYNLGVRSKKKYFDFE-EIVAFV NHHWDLLQLGKLTGTPTAERG---------------PHISDALNSYKSRFLCGKE-IKKKKCIFR-----LRIRVPP--N PPSKLLPEKIPGSVD--GGANGPKKRDSK--------------------------------PGLLMPAAPQLASNQER-- --RRKRSKFLLEDAIPSSDFASA----------------------------------------WSTNHHLASIFDFTLDE IQSLKS------------ASSSHTFLSDVDSTDAVSTSGSATTSLSYQS------------------------------- -------------------------------------------------------------------------------- -----------R-------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------- >Xenopus_tropicalis_PHF19 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------Q------------VSSSKQSCLVTFEDN SKYWVLFKDIQHAG----------VPGEQPKCNVCTGKSSL------------------------PLNEILICGKCGLG- ---------------------YHQKCHIPVVDSGENGPLEP------------------------------------WFC RRCIF---------------------------VLAVRKGGALKKGPIAKA------------------------------ ------LQAVKMYLTYSPTELDWDSPHRTNQQQCYCYCGGPGEWYLKMIQCYRCRQWFHEAC-MQCLNEPMMFGDSR--- --------------------------FYAFLCSVCNQGSEFLKRLPLRWV-DIVHLALYNLGVLSKKKYFDFE-EILTFV NDNWDHLQLGKIAATLVEERA---------------HHLLDALNSYKSRFLCGKE-IKRKKCIFR-----LRIRVPP--S PPGKLLPEKAVGTAE--SRSADLKKKGRSK-YS----------------------------HKNSLPHECQRQRQQGI-- --RRKQSKFLLEDAIPSSDFTSA----------------------------------------WSTNHHLASIFDFTLDE IQSLKS------------ASSGQNFTSDLDSNDAASTSGSASTSLSCES------------------------------- -------------------------------------------------------------------------------- -----------RGNVGSRKRKFASKKYTSFEAKRRAVDRTGRLNGCATEAAEYVGASDYQDHSIESRTFDS--------- -------------------------------------LSENDTSLSHLKSSITSYFG-AAGRMACGEKYQVLARR----- ------------------------------VTLEGKVQYLVEWEGTTPY------------------------------- --------------------------------------------- >Danio_rerio_PHF19_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MLESACRD GYLTAGSESLEPKHLHPNIEKSICDQETSLTVGQYVLCCWSDG-LYYLGKIQR------------VSTSKQSCFVSFEDN SKFWVLWKDIQHAG----------IPGEEPKCSVCSDMSLD------------------------PGNEILICGKCGVG- ---------------------FHQLCHLPTVESSA--DPSP------------------------------------WFC RRCIF---------------------------ALAVRKGGALKKGQLAKD------------------------------ ------LQAMKQVLTYNPEELEWDSLHRTNHQQCYCYCGGPGQWYLKMLQCFRCEQWFHEAC-TQCLQDSMMFGDR---- --------------------------FYLFICAVCNKGVEYIKRLALRWV-DVVHLALYNLGVQSKKKYFELE-EIVAFI NNNWDRFQMGKLSNTPLPERG---------------QLILDALNNYKSKFLCGKE-IKKRKCIFR-----LRTRVPP--N PPSKLYPEKAQKSDA-HRGRKKAVSRSSN--------------------------------------SDPAEKRRK---- ----KRAKWLLEDAIPNNDLTSS----------------------------------------WSTNHHMANIFDFTLDE LQSLKS------------TSSGQTFSLDQDSTDAASTSGSATTSVSYDF------------------------------- -------------------------------------------------------------------------------- -----------RKNVGSRKRKLPTSNYNLLATKR---ELVER--EPSPINMPGEERNVLMENGIDSHTFES--------- -------------------------------------ISEDDSSLLHLKSSITSYFG-AAGRLTCGEKYQVLARR----- ------------------------------ITPEGKVQYLVEWEGTTPY------------------------------- --------------------------------------------- >Takifugu_rubripes_PHF19_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------SRMLENLTG PFSDLKPHVSPRGGTYGEGRGLEEEMASNLTVGQFVLCHWSDG-LYYLGKIHR------------VSPPRQSCFVTFEDN SKFWVLWKDIQHAG----------VPGEEPRCSVCKEGDIDGDNQTN------------------QSNQILICGKCGIG- ---------------------FHQHCHVPPVEGSI--VTSP------------------------------------WFC RRCVF---------------------------ALAVRKGGALKKGPLSKT------------------------------ ------LWAMKQVLPYKVESLDWDSQHRTNQQQCYCYCGGPGEWYLKMLQCFRCQQWFHEAC-TQCLQCSMMFGDR---- --------------------------FYLFLCAVCNKGSEYIRRLSLRWV-DLVHLVLYNLSVSSKKKYFELD-EILDFV SENWDQLQLGKLSNTPAADRG---------------KHLLDALNKYKSKFLCGKE-IKKRKCIFR-----LRTRVPP--N PSSKLFPERIQSDGG-RGCKKFGVRARKKNK--------------------------------SLSRSSSSAERKK---- ----RKAKWLLEDAIPNNGISCRS---------------------------------------WASNHHMANIFDFTLDE LQSLK-------------SSSSRAVSIDQDSTDVS-TSGSATTSTSYHS------------------------------- -------------------------------------------------------------------------------- -----------RRRVGSRKRKLPSNTHCQWASHR---EMTEE----SSVLLDDQDSMIHTHVSNSSHFLSD--------- -------------------------------------PSEIPSDSSHLHSSISSYFG-IAGRLTNGERYQVLARR----- ------------------------------ITPQGTVQYLLEWEGATPY------------------------------- --------------------------------------------- >Tetraodon_nigroviridis_PHF19_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PREGTFEEGSSLEEDKASNLTVGQFVLCHWSDG-LYYLGKIQR------------VSPPRQSCFVTFEDN SKFWVLWKDIQHAG----------VPGEEPRCSVCKEGDSDGDDQSD------------------QSNQILICGKCGIAG ---------------------FHQQCHVPPVEGSS--ATSP------------------------------------WFC RRCVF---------------------------ALAVRKGGALKKGPLSKT------------------------------ ------LWAMKQVIPYNVEHLDWDSQHRTNQQQCYCYCGGPGEWYLKMLQCFRCQQWFHEAC-TQCLQYSMMFGDR---- --------------------------FYLFLCAVCNKGSEYIRRLSLRWV-DLVHLVLYNLSVSSKKKYFELD-EILDFV SENWEQLQLGKLSNTPAADRG---------------KHLLDALNKYKSKFLCGKE-IKKRKCIFR-----LRTRVPP--N PSSKLFPERTTTQKK-LSPLKKKRKARKDGG--------------------------------SVWENSFSAERKK---- ----RKAKWLLEDAIPTNEMSCRS---------------------------------------WASNHHMASIFDFTLDE LQSLK-------------SSSSRAVSVDQDSTDAS-TSGSATTSTSYHL------------------------------- -------------------------------------------------------------------------------- -----------RRRMGSRKRKLPSNTHCQWAGRK---EAGEE----CPGLLDDQDAMIHAHVSNSSHFLSD--------- -------------------------------------PAKIPSDSSHLHSSISSYFG-IAGRLTNGERYQVLARR----- ------------------------------VTPQGTVQYLLEWEGATPY------------------------------- --------------------------------------------- >Gasterosteus_aculeatus_PHF19_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------LSTCRMFEDLIE AFCGLEPQVAQGGGTCRKGQSPREEAQFSLSVGQFVLCHWSDG-LYYLGKIQR------------VSPPRLSCFVTFEDN SKFWVLCKDIQHAG----------VPGEEPRCSVCQEAEPNADNQSN------------------PNNQILICGKCGIG- ---------------------FHQQCHLPPVESSV--SLSP------------------------------------WFC RRCVF---------------------------ALAVRKGGALKKGPIAKA------------------------------ ------LSAMKQVFPYDLDSLDWDSQHRTNHQQCYCYCGGPGEWYLKMLQCFRCQQWFHEAC-TQCLQESMMFGDR---- --------------------------FYLFLCSVCNKGSEYVRRLSLRWV-DLVHLVLYNLSVSSKKKYFELD-EILTLV SASWEPLQLGKLSHTPPSERG---------------QHLLDALNKYKSKFLCGKE-IKKRKCIFR-----LRTRVPP--N PPSKLFPERSQSDGG-LGHKKRPVRRGSP----------------------------------VVIPFSASAEKRK---- ----RKSKWLLEDAIPN---SCS----------------------------------------WTSNHHMANIFDFTLDE LQSVKRF-----------SCSSRSVSIDQDSTDAS-TSGSATTSASYHF------------------------------- -------------------------------------------------------------------------------- -----------RRKVGSRKRKLPSNGYKYWASRS---EVGEELRGEEPSRMLEDQEALTHLTADSSHFLSD--------- -------------------------------------PTQIPSDSSHLHSSISSYFG-VAGRLTNGETYQVLARR----- ------------------------------ITPQGTVQYLLEWEGTTPY------------------------------- --------------------------------------------- >Oryzias_latipes_PHF19_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------SSLSVGQFVLCHWSDG-LYYLGKIQR------------VSPPRQSCFVTFEDN SKFWVLLKDIQHAG----------VPGEEPRCSVCRRAEPDSDGQPK------------------VNNQILICGKCGIG- ---------------------FHQLCHIPPVEGS---SLSP------------------------------------WFC RRCVF---------------------------ALAVRKGGALKKGPIAKA------------------------------ ------LCAMKQVLSYKLDSLDWDSQHRTNQQQCYCYCGGPGD--------------------TQCFQESLMFGDR---- --------------------------FYLFLCAVCNKGCEYIRRLPLRWV-DVVHLVLYNLSVSSKKKYFELD-EILAFV STNWDHLQLGKLSNTPPADRG---------------QHLLDALNNYKSKFLCGKE-IKKRKCIFR-----LRTRVPP--N PPSKLLPEHALHDGG-RGRKTTSDAWGSWKSIF----------------------------VFLCFCFSSSAERKR---- ----RKSKWLLEDAIPNNELSCS----------------------------------------WTSNHHMANIFDFTLDE LQSLK-------------SSSNRTVSIDQDSTDAS-TSGSATTSASYRL------------------------------- -------------------------------------------------------------------------------- -----------KSRVGSKKRKLPSNSYSQWANRS---EVDEEPAETAEERAAAPD---ARLNTELPHFLSD--------- -------------------------------------PAHIASDSSLLHSSISSYF----GRLSSGERYQVLARR----- ------------------------------VTPQGMVQYLLEWEGTTPF------------------------------- ---------------------------------------------