>HUMAN_OSBPL3 -------------------------------------------------------------------------------- ---------------------------------------------------MMSDEK--NLGVSQKLVSPSRST-SSCSS KQGSRQ-------------------------------------------------------DSWEVVEGLRGEM-NYTQE PPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKS EEVFDEWVSKLRHHRMYRQNEIAMFPHEVN-----------------HFFSGS----TITDSSSGVFDSISSRKRSSISK QNLFQTG----SNVSFSCGG-ETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MDVLHRTYS------------APA-INAIQGGSFESPK-KEKRSHRRWRSRAI GKDAKGTLQ-------------------------VPKPFSG-PVRLHSSNPNLSTLDFGEEKNYSDGS---ETSSEFSKM QEDLCHIAHKVYFTLRSAFNIMSAEREKLKQLM-EQDASSSPSAQVIGLKNALSS-------------------ALAQNT DLKERLRRIHAESLLLDSPAVAKSGDNLAEENSRDE-NRALVHQLSNESRLSIT--DSLSEFFDAQEVLLS-----PSSS ENEISDDD------------SYVSD-----ISDNLSLDNLSNDLDNERQTLGPVLDS--GREAK---------------S RRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLN-TLQRLCEELEYSELLDKAAQ-IPSPLERMVYVAAF AISAYASSYYRAGSKPFNPVLGETYECIR--EDKGFQFFSEQVS-HHPPISACHAESRNFVFWQDVRWK--NKFWGKSME IVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYG-EIVIKNLHDDSCYCKVNFIKAKYWSTNAH-EIEGTVFD RSGKAVHRLFGKWHESIYCGGGSSSA------------------------CVWRANPMPKGYEQYYS------------- FTQFALELNEMDPSSKSLLPPTDTRFRPDQR--FLEEGNLEEA---EIQKQRIEQLQRER-------------------- -----------------------RRVLEE----------NHVEHQPRFFRKSDD-------DSWVSNGTYLELR------ -----------------KDLGFSKLDHPV--LW------------------------------- >MOUSE_OSBPL3 -------------------------------------------------------------------------------- ----------------------------------------------------MSDEK--NLGVSQKLVSPSRST-SSCSS KQGSRQ-------------------------------------------------------DSWEVVEGLRGEM-TYTQE PPVQKGFLLKKRKWPLKGWHKRFFCLEKGILKYAKSQADIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKS EELFDEWVSKLRHHRMYRQNEIAMFPRDVN-----------------HFFSGS----SVTDSAPGVFESVSSRKRSSLSK QNSFPPG----SNLSFSCGG-DTRVPFWLQSSEDMEKCSKDMAHCHAYLLEMSQLLES---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MDVLHRTYS------------APA-INAIQ----------------------- ----------------------------------VPKPFSG-PVRLHSSNPNLSTLDFGEEKSYSDGS---EASSEFSKM QEDLCHVAHKVYFALRSAFNSISVEREKLKQLM-ELDTSPSPSAQVVGLKHALSS-------------------ALAQNT DLKERLRRIHAESLLLDPPAVPKPGDNLAEENSRDE-GRALVHQLSNESRLSIT--DSLSEFFDAQEVLLS-----PSSS ENEISDDD------------SYVSD-----ISDNLSLDNLSNDLDNERQTLGPVLES--SGEAR---------------S KRRTSLPAPGPNTSSVSLWSILRNNIGKDLSKVAMPVELNEPLN-TLQRLCEELEYSELLDKASR-IPSPLERMVYVAAF AISAYASSYFRAGSKPFNPVLGETYECIR--QDKGFQFFAEQVS-HHPPISACHAESGNFVFWQDVRWK--NKFWGKSME IVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYG-EIDIKNLNDDSCHCKVNFIKAKYWSTNAH-EIEGTVFD RSGKAVHRLFGKWHESIYCGGASSST------------------------CVWRANPMPKGYEQYYG------------- FTQFALELNEMDPLSRSLLPPTDTRFRPDQR--LLEEGDIEEA---EVQKQRIEKLQRER-------------------- -----------------------RRVLEE----------NGVEHQPRFFRKSSD-------DAWVSNGTYLELR------ -----------------KDLGFSKLDHPV--LW------------------------------- >RAT_OSBPL3 -------------------------------------------------------------------------------- ----------------------------------------------------MSDEK--NLGVSQKLVSPSRST-SSCSS KQGSRQ-------------------------------------------------------DSWEVVEGLRGEM-TYTQE PPAQKGFLLKKRKWPLKGWHKRFFCLEKGILKYAKSQTDIEREKLHGSIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKS EDVFDEWVSKLRHHRMYRQNEIAMFPRDVN-----------------HFFPGS----SVTDSAPGVFESVSSRKRSSLSK QNSFPAG----SNLSFSCGG-DTRVPFWLQSSEDMEKCSKDLAHCHTYLLEMSQLLES---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MDVLHRTYS------------APA-INAIQGGAFESPK-KEKRSHRRWRSRAI GKDAKGMLQ-------------------------VPKPFSG-PVRLHSSNPNLSTLDFGEEKSYSDGS---EASSEFSKM QEDLCHVAHKVYFALRSAFNSISMEREKLKQLM-ELDTSSSPSAQVVGLKHALSS-------------------ALAQNT DLKERLRRIHAESLLLDPPAGPKPGDNLAEEISRDE-SRALVHQLSNESRLSIT--DSLSEFFDAQEVLLS-----PSSS ENEISDDD------------SYVSD-----ISDNLSLDNLSNDLDNERQTLGPVLES--SGEAR---------------S KRRTSLPAPGPNTSSVSVWSILRNNIGKDLSKVAMPVELNEPLN-TLQRLCEELEYSELLDKAAH-MPSPLERMVYVAAF AISAYASSYFRAGSKPFNPVLGETYECIR--QDKGFQFFAEQVS-HHPPISACHAESRNFVFWQDVRWK--NKFWGKSME IVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYG-EIVIKNLRDDSCHCKVNFIKAKYWSTNAH-EIEGTVFD RSGKAVHRLFGKWHESIYCGGASSST------------------------CVWRANPMPKGYEQYYG------------- FTQFALELNEMDPLSRSLLPPTDTRFRPDQR--LLEEGNIEEA---EVQKQRIEKLQRER-------------------- -----------------------RRVLEE----------NGVEHQPRFFRKSSD-------DAWVSNGTYLELR------ -----------------KDLGFSKLDHPV--LW------------------------------- >COW_OSBPL3 -------------------------------------------------------------------------------- ----------------------------------------------------MSDEK--SLAVSQKLVSPSRST-SSCSS KQGSRQ-------------------------------------------------------DSWEVVEGLRGEM-NYTQE PPIQKGFLLKKRKWPLKGWHKRFFYLDRGILKYAKNQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKS EDVFDEWVSKLRHHRMYRQNEIAMFPHEVN-----------------HFFPGS----TVPDSGPGVMDTISSRKRSSISK QNSFQTG----SNLSFSCGG-ETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQN---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MDILHRTYS------------APA-INAIQGGAFESPK-KEKRSHRRWRSRAL GKDAKGTLQ-------------------------VPKPFSG-PIRLHSSNPNLSTLDFGEEKNYSDGS---ETSSEFSKM QEDLCHIAHKVYFTLRSAFNTISTEREKLKQLM-EQDVSASPSAQVLGLKHALSS-------------------ALAQNT DLKERLCRIHAESLLLDLPAAAKSGDGLAEENSRDD-SRALVHQLSNESRLSIT--DSLSEFFDAQEVLLS-----PSSS ENEISEDD------------SYVSD-----ISDNFSLDNLSNDLDNERQTLGPVIDS--GGEAR---------------S KRRTCLPAPCPKSSNISLWNILRNNIGKDLSKVAMPVELNEPLN-TLQRLCEELEYSELLDKAAQ-LPNALERMVYVAAF AVSAYASSYFRAGSKPFNPVLGETYECIR--EDKGFRFFSEQVS-HHPPISACHAESANFVFWQDVRWK--NKFWGKSME IVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYG-EIVIKNLNDDSCHCKVNFIKAKYWSTNAH-EIEGTVFD QSGKAVHRLFGKWHESIYCGGSSSSA------------------------CIWRANPMPKGYEQYYG------------- FTQFALELNEMDPLLKSLLPPTDTRFRPDQR--FLEEGNLEEA---EIQKQRIEQLQRER-------------------- -----------------------RRVLEE----------NKVEHQPRFFRCVNGGVLRVI-VGRVLDVAGKNVR------ -----------------KGGNCSAVAVLE--LFQLEAGRDDREEEYGDLDVSIDTKESPKY--- >HORSE_OSBPL3 -------------------------------------------------------------------------------- ---------------------------------------------------MMSDEK--NLGVSQKLVSPSRST-SSCSS KQGSRQ-------------------------------------------------------DSWEVVEGLRGEM-NYTQE PPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKS EEVFDEWVSKLRHHRIFRQNEIAMFPHEVN-----------------HFFPGS----AGTDSPSGALDSISSRKRSSISK QSSFQTG----SNLSFSCG--ETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMNQLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MDVLHRTYS------------APA-INAIQGGAFESPK-KEKRSHRRWRSRAI GKDAKGTLQ-------------------------VPKPFSG-PVRLHSSNPNLSTLDFGEEKNYSDGS---ETSSEFSKM QEDLCHIAHKVYFTLRSAFTIMSAEREKLKQLM-EQDASCTPSAQVIGLKHALSS-------------------ALAQNT DLKERLCRIHAESLLLDPPAAAKSGDTLAEENSRDD-NRALVHQLSNESRLSIT--DSLSEFFDAQEVLLS-----PSSS ENEISEDD------------SYVSD-----ISDNLSLDNLSNDLDNERQTLGPVLES--GGEAK---------------S KRRTCLPAPGHNSSNISLWNILRNNIGKDLSKVAMPVELNEPLN-TLQRLCEELEYSELLDQAAR-VPSALERMVYVAAF AVSAYASSYFRAGSKPFNPVLGETYECIR--EDKGFQYFSEQVS-HHPPISACHAESRNFVFWQDVRWK--NKFWGKSME IVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYG-EIVIKNLSDDSCHCKVNFIKAKYWSTNAH-EIEGTVFD KNGKAVHRLFGKWHESIYCGGASSST------------------------CVWRANPMPKGHEQYYG------------- FTQFALELNEMDPLLKSLLPPTDTRFRPDQR--FLEEGNLEEA---ERQKQRIEQLQRER-------------------- -----------------------RRVLEE----------NNVEHQPRFFRKSDD-------DSWVSNGTYLELR------ -----------------KDLGFSKLDHPV--LW------------------------------- >OPOSSUM_OSBPL3 -------------------------------------------------------------------------------- ----------------------------------------------------MSDEK--GLGLSQKLVSPSRST-SSCSS KQGSRQ-------------------------------------------------------DSWEVVEGLRGEM-TCTQE PQIQKGFLLKKRKWPLKGWHKRFFFLEKGILKYAKNLADIEREKLHGSIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKS EEVFEEWVAKLRHHRVYRQNEIAMFPRDVN-----------------HFFPGS----TVTDSASGVFDSVSSRKRSSISK QSSLQTG----SSLSFSCG--EARVPIWPHSSEDMEKCSKDLAHCHTYLIEMSQLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MEVLHRTYS------------APA-INALQGGAFESPK-KEKRPHRRWRARAI SKEAKGMLQ-------------------------VPKPYSG-PVRLHASNPNLSTLDFGEDKNYSDGS---ETSSEFSKM QEDLCHIAHKVYFTLKSAFNTLSNEREKLRQIS-DHDYSSSPSAQIVGLKHALSS-------------------ALAQNT DLKERLRRIHAESLFLDSAAGAKSSDGLAEEISGEE-GRALVHQLSNESRLSIT--DSLSEFFDAQEVLLS-----PSSS ENEVSDDD------------SYVSD-----VSDNASVDNLSNDLDSERQTLGPILESDPGGQTRG-------------QT QRRTSLPAPCPNTSNISLWNILRNNIGKDLSKVAMPVELNEPLN-ALQRLCEELEYSELLDQASR-TPDPLERMVYVAAF AVSAYASSYFRAGSKPFNPVLGETYECIH--EEKGFQYFSEQVS-HHPPISACHAESANFVFWQDVRWK--NKFWGKSME IVPVGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYG-EIIIKNLNEDSCHCKVNFIKAKYWSTNSH-EIEGTVFD KAGKAVRRLFGKWHESIYSGTRSSST------------------------CIWRAHPMPKGHEQYYG------------- FTQFALELNELDSLTRPFLPPTDTRFRPDQR--LLEEGNLEEA---ETQKQRVEQLQRER-------------------- -----------------------RRVMEE----------NNLEHQPRFFRKSSD-------DSWVSNGTYLDLR------ -----------------RDPGFSKLDNPT--LW------------------------------- >PLATYPUS_OSBPL3 -----------------------------------------------------------------------MLVDLVSIK IKAGINFPQPQKASLHLLPNPVEKDVNQTPPAKRQAVSIRLWLKVRCGFLALKSQDRGLSLVLDEKLQQPQHLA-QGACT DKHS---------------------------------------------------------DSWEVVEGLRGSM-NYTQE PPEQKGYLLKKRKWPLKGWHKRFFFLDKGILKYAKSQADVEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKS EDVFDEWVAKLRHHRVYRQNEIAMFPRDVN-----------------HFFPGS----TVTDSAPGMFDSVSSRKGSSLSK QNSVQTG----SGFSFACTSGETRIPLWLQSSEDMDKCSKDLTHCQAYLQEMSQLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MEVLHRTYS------------APA-INVIQGGAFESPK-KEKRSQRKWRSRAI GKDAKGTLQ-------------------------VPPVYPG-LVRLHASNPNLSTLDFGEEKNYSDGC---ETSTEFSKM QEDLCHIAHKVYFTLSSAFNTISSEREKLKQML-EREASSSPSAQIVGLKHALSS-------------------AVAQNT DLRDRLRRIHAESVLLDSATFAQSSDILAEENSREG-NRVLVHQLSNESKLSIS--DSLSEFFDAQEVLLS-----PSSS ENEISDDD------------SYASD-----LSDNISEDNLSNDLDNERQTLGPVVES--VGGSQ---------------S KRRTCLPAPCPNTSNISLWNILRNNIGKDLSKVAMPVELNEPLN-TLQRLCEELEYSELLDKAVL-LDNPLERMVYVAAF AISAYASSYFRAGSKPFNPVLGETYECIR--EDKGFQFFSEQVS-HHPPISACHAESKNFVFWQDVRWK--NKFWGKSME IVPIGTTHVTLPSFGDHFEWNKVTSCIHNILSGQRWIEHYG-EIIIKNQNDESCHCKVNFIKAKYWNPNAH-EIEGTVFD KNGKAVHRLFGKWHESIYCGTPSSAT------------------------CIWRANPMPKGYEQCYG------------- FTQFALELNEMDPSIRALLPPTDTRFRPDQR--FLEEGDIEGA---EFQKQRIEQLQRER-------------------- -----------------------RRVLED----------NNMEHQPRFFRKSED-------ESWVSNGTYLDLR------ -----------------KDLGFSKLDNPI--LW------------------------------- >CHICKEN_OSBPL3 -------------------------------------------------------------------------------- ----------------------------------------------------MSEEK--NFGASQKMLSPSRST-SSCSS KQGSRQ-------------------------------------------------------DSWEIVEGLRGAM-NCTQE PQKQEGCLLKKRKWPLKGWHKRYFFLDRGILKYSKCQADIERGKLHGCIDVGLSVMSVKKSTKCIDLDTEEQIYHLKVKS QELFDEWVAKLRHHRMYRQNEISMFPHDVNN----------------LFFPVS----TTVDSGPGLCDLTPSRKAGSLTK QNSLSAG----GNLSFSFSSNESRIPSWLQSSEDMEKCSRDLSTCHAYLLEMNQLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MDVLHRTCS------------APA-INAMQVGPFESPK-KEKRAHRRWRSRVV GKEAKGTLQ-------------------------VPSVFSA-PMRLHASNPNLSTIDFVEEKNYSDGS---ETSSEFTKM QEDLVHIAHKVYFTLKSAFSSISTEREKLKQML-EHEASSSPSAQIVGLKNALTS-------------------AIAQNT DLKDRLRRIHAESMILDSASNAKSSPDLVKENSREE-NRGLVHQISNESRLSIA--DSLTEFFDAQEVLLS-----ASSS ENEVSDDD------------SYVSD-----ISDNVSEDNLSNDIENERQTLDCISES--GIGCH---------------S KRRTCLPAPCPNTSNISLWNILRNNIGKDLSKVAMPVELNEPLN-TLQRLCEELEYSELLDKAAH-TPNPFERMVYIAAF AVSAYASSYYRAGSKPFNPVLGETYECIR--EDKGFQFFAEQVS-HHPPISACHAESVNFAFWQDVRWK--NKFWGKSME IVPVGTTHVTLPAFRDHFAWNKVTSCIHNILSGQRWIEHYG-EIIIKNLNDDTCYCKLTFIKAKYWNPNAH-EIEGSVMD KTGNVVHRLFGKWHESLYCGTTSSSK------------------------CIWRANPMPKDYEQWYG------------- FTQFALELNELDLQTRSLLPSTDTRFRPDQR--FLEEGNIEAA---EMQKQRIEQLQRER-------------------- -----------------------RKVLEE----------NNLEHQPRFFRKSKD-------DSWVSNGTYMDLR------ -----------------REPGFSKLDNPV--LW------------------------------- >ANOLE_LIZARD_OSBPL3 -------------------------------------------------------------------------------- ---------------------------------------------------IMTEEK--NLGVSQKVLSPSRST-SSSSS KQGSRQ-------------------------------------------------------DSWEIVEGLRGAM-NYTQE PQKQEGYLLKKRKWPLKGWHKRCFFLDRGILKYAKSPADIERGKLHGCIDVGLSVMSVKKSTKCIDLDTEEHIYHLKAKS QEVFDEWVRQLRHHRMYRQNEISMFPHDINN----------------HFFPASS---SITDSVTGFLESPTSRKRGTLTQ QNSVQTG----SSLSFSCSANESRIPPWLHSSEEMERCSKELSHCHSYLLEMSQLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MEVLHRTYS------------APA-INAMQGIPFESPK-KEKRSHRRWRSRAL GKDTKAMLQ-------------------------VPSVLSA-PLRLHASNPNLSTLDFAEEKIYSNGS---ETTSEFSKM QEDLCHIAHKVYFTLKSAFSTISTEREKLKQMF-DHDAVSSPSAQIVGLKNALSS-------------------AIAQNT DLKDRLRRIHAESMLLDSAANAKSNPDLAKENSEDE-SRGLVHQLSNESRLSIT--DSVTEFFDAQEVLLS-----ASSS ENEVSDDD------------SYASD-----ISDNISEDNLSNDIENERQPLDCVPDG--RVESH---------------S KRRTCLPAPCPNTSNISLWNILRNNIGKDLSKVAMPVELNEPLN-TLQRLCEELEYSELLDKAAH-TPDMFERMVYVAAF AVSAYASSYYRAGSKPFNPVLGETYECVR--EDKGLQYFSEQV------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------- >ZEBRAFISH_OSBPL3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------MKGWHKRYFYLDKGILKYAKCAADVEKGKLHGCIDVGLSVMAIKKKAKCIDLDTEENIYHLKIKS QELFDEWVSKLRHHRLYRQNEIAMFPHEKA-----------------LFHPHYP--LTSSPT--------IPD---SQAI RKRPS----------------DLLVTAWLQSSDDMDRCTKELSVCEAQLLELNHLLRS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MEVLHRTYS------------APA-INALQASTYDSPK-KEKRHPRKWRPKNY GKDNKTTLQ-------------------------VPSCISAGSVRLHASNPNLSSVDLTTEKTYHEPL---DSPIDVSKL QEDFCRVANNLHTTMKSALCMLTTEKERVKQML-DYILDQ---------------------------------------- -------------------------------DSSDC-SRPLVHQASNESRASIS--ESLSEFFDAQEVLLS-----ASSS ENEASEDD------------SYISD-----ISDNVSMDNFSNEAENERLNT-----GGNDAFLQ---------------- -RRSCLPSPSPNTSNISLWNILKNNIGKDLSKVAMPVELNEPLN-TLQRLCEELEYSELLDKAAH-TQDPFERMVYIATF AVSGYASSYYRAGGKPFNPVLGETYECDR--PDKGFRFVAEQVS-HHPPISSCHAESKNFIFWQDVRWR--NKFWGKSME IVPVGSSHVVLPGFGDHYEWNKVTSCIHNILSGQRWIEHYG-EISIKNSNSEKCQCKVTFIKAKYWNSSMN-EVEGSVTD HKGKVVHKLFGKWHEGMYCGSPPSAT------------------------CIWRTNPMPPEFEQYYG------------- FTKFAMELNELDPLTKPLLPPTDTRLRPDQR--LLEEGNVQSA---EVQKQRIEQLQRER-------------------- -----------------------RKVLEE----------NHMTHQPRFFQKSKD-------ETWVSNNTYWDLR------ -----------------KDPGFSNLDCPV--LW------------------------------- >FUGU_OSBPL3 -------------------------------------------------------------------------------- ---------------------------------------------------------------KMTSPSPTHSDNSSSSS KHDGNQ-------------------------------------------------------DSWEIIEGLRGVS-ANIQE PDRQEGFLLKRRKWPMKGWHKRYFLLEKGILKYAKRAADLKKGKLHGCIDVGLSVMSIKKKAMCIDLDTEDNIFHLKVKS QELFEEWVSKLRHHRVFRQNEIATYPHERH-----------------LFYPHTS--PSLNES--------MKK-RSTLTK QTSIH----------------QSKLSSWLHSSMDMDKCCKDLEECESYLLELNLLLKS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MEVLHRTYS------------APA-ISGLQASTYELPK-KEKRQ-RKWRSKNN GKETKSTLQ-------------------------VPSCISSQSPRFHASNPNLSTTDSNAQELCPESP---DSPTEVSRL QQDFCRLANNIHGRLKSTLSTMLAEQDRLRQTI-EVQAPQP--AQVMGLKTAYAS-------------------PLSVNL FP---------------------------YQECSGG-SHSLVHQASSESKASIP--ESISEFFDAQEYLLS-----SSSS ENEVSDDD------------SYISD-----VSDSISMDTCSNEGNSERQNS----VSGAVTLVR---------------- -RRSTLPSPRPSSS-VSLWNILRNNIGKDLSKVAMPVQLNEPIN-TLQRLCEELEYSELLDTANQ-TQDPYQRMVYVATF AVSAYASTHHRAGSKPFNPVLGETYECDR--PDKGFRFIAEQVK-HHPPVSACHSDSQNFTFWQDVRWK--NKFWGKSME IVQMGTTHVTLPAFGDHYEWNKVTSCIHNILSGQRWIEHYG-EMAIKNINSDNCQCKITFVKANSWSSSVN-EIEGVVTD SKGKVVHSIFGKWHESVFQGDPPTAM------------------------CIWRANPMPSDQEQYYG------------- FTQFAMELNELEPSLRLRLPPTDTRFRPDQR--FLEEGNVDGA---EEQKQRIEQLQRER-------------------- -----------------------RKVLQD----------NNMTHKPRFFKKSNN-------DTWVSNNTYWDLR------ -----------------REPGFSKIDFPV--LW------------------------------- >MEDAKA_OSBPL3 -------------------------------------------------------------------------------- ----------------------------------------------------SSSTRHLSENRKMTTPSPTHSD-SSDSS KHESNR-------------------------------------------------------DSWEIVEGLRGVP-ASMQE PDRQEGFLLKRRKWPMKGWHKRYFVLVKGIMTYGKRGTDIQKGKIHGCIDVGLSVMSIKKKAMCIDLDTEDNIYHLKVKS SELFEEWVSKLRHHRLFRQNEIAVYPHERH-----------------LFHPHASSSPTFNDS--------YRR--STLTK QASVH----------------QAKVSSWLHSSEDMNKCSKELEECESYLLELNLLLKS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MEVMHRTYS------------APA-ITSLQASAYDNPK-KEKRP-KRWRSKNN GKETKATLQ-------------------------VPSCISSQSPRLHASNPNLSTTSS--QEVCSESP---DSPTDVSRL QEDFCRLANNIHTTLKSAHSSLTAERDRLKHTI-DLQGPQP--AQVVGLKGVFSS-------------------VSSRAH QKVIHCVFD---------------------QESPGT-PQSLVHQISNESKTSIP--ESISEFFDAQEYLLS-----SSSS ENEVSDDD------------SYVSD-----VSDSVSMDTFD--GRSERQNSGTGILSSVVTVAR---------------- -RRSTLPSTCPSSS-VSLWNILRNNIGKDLSKVAMPVQLNEPLN-TLQRLCEELEYSNLLDIANQ-THDPYQRMVFVATF AISAYTSTYCRAGSKPFNPVLAETYECDR--PEKGFRFIAEQVS-HHPPVSACHADSKNFKFWQDVRWK--NKFWGKSME IVPIGTTHVTLPAFGDHYEWNKVTSCIHNILSGQRWIEHYG-EMSIKNVNGDVCQCKITFIKAKSWSSTVN-EIKGVVTN AEGKTVHSIFGKWHESVFQGDPPSAT------------------------CIWRAKPMPKDQEQYYG------------- FTQFAVELNELDSNLRPLLPPTDTRFRPDQR--LLEEGNIDGA---EEQKQRIEQLQRER-------------------- -----------------------RKVLQD----------NNMTHQPRFFKKSKD-------DTWISNNTYWELR------ -----------------RDSGFSKMDFSV--LW------------------------------- >TETRAODON_OSBPL3 -------------------------------------------------------------------------------- --------------------------------------------------------------------SPTHSD-SSSSS KPDGNQ-------------------------------------------------------DSWEIVEGLRGFS-ATMQE PDRQEGFLLKRRKWPMKGWHKRYFGLEKGILKYAKSATDLKKGKLHGCIDVGLSVMSIKKKAMCIDLDTEANIFHLKIKT QELFEEWVSKLRHHRVFRQNEIAMYPHERH-----------------LFYPHSS--PSLNES--------MKKQRSTLTK QTSIH----------------QAKVSSWLHSSVDMDKCCKDLEECESYLLELNLLLKS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MEVLHRTYS------------APA-ISGLQASTFELPK-KEKRQ-RKWRSKNN GKETKSTLQ-------------------------VPSCISSQSPRLHASNPNLSTTDSNTQELSPESL---DSPTEVSRL QQDFCRLAYNIHGRLKSTLSTLLAERDRLRQTI-DLQAPQP--VQLMGLKNAYAS--------------------VSVST IPKIPVRPVCPR----------------RYQECSDG-PHSLVHQASSESKASIP--ESISEFFDAKEYLLS-----SSSS ENEVSDDD------------SYISD-----VSDSISMDTCSNEGTTERQNS----VSSVVALVR---------------- -RRSTLPSPRPSSS-VSLWNILRNNIGKDLSKVAMPVQLNEPIN-TLQRLCEELEYSELLDTANQ-TQDPYQRMVYVATF AISAYASTYHRAGSKPFNPVLGETYECDR--PDKGFRFIAEQVK-HHPPVSACHSDSKNFTFWQDVRWK--NKFWGKSME IVPMGTTHVTLPAFGDHYEWNKVTSCIHNILSGQRWIEHYG-EMAIKNLNSDACQCKITFVKANSWSSSVN-EIEGVVTD SKGKVVHSIFGKWHESIFQGDPPTAM------------------------CIWRANPMPLDQEQYYG------------- FTQFAMELNELDSSLRPLLPRTDTRFRPDQR--LLEEGNVDGA---EEQKQRIEQLQRER-------------------- -----------------------RKVLQD----------NNMTHKPRFFKKSNN-------DNWVSNNSYWDLR------ -----------------REPGFSKVDFPV--LW------------------------------- >HUMAN_OSBPL6 -------------------------------------------------------------------------------- ----------------------------------------------------MSSDEKGISPAHKTSTPTHRSASSSTSS QRDSRQS---------------------IHILERTASSS-TEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQ-TNVQK PDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKS QDWFDAWVSKLRHHRLYRQNEIVRSPRDASF----------------HIFPSTSTAESSPAANVSVMDGKMQPNSFPWQS PLPCSN------SLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQN---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEILQRTQS------------APN-FTDMQANCVDISK-KDKRVTRRWRTKSV SKDTKIQLQ-------------------------VPFSATMSPVRLHSSNPNLCAD-IEFQTPPSHLTDPLESSTDYTKL QEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQ-------------------ALNQNA ELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANESRLSMS--ESVSEFFDAQEVLLS-----ASSS ENEASDDE------------SYISD-----VSDNISEDNTSVADNISRQILNGELTG--GAFRN---------------- GRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLN-TLQHLCEEMEYSELLDKASE-TDDPYERMVLVAAF AVSGYCSTYFRAGSKPFNPVLGETYECIR--EDKGFRFFSEQVS-HHPPISACHCESKNFVFWQDIRWK--NKFWGKSME ILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYG-EVTIRNTKSSVCICKLTFVKVNYWNSNMN-EVQGVVID QEGKAVYRLFGKWHEGLYCGVAPSAK------------------------CIWRPGSMPTNYELYYG------------- FTRFAIELNELDPVLKDLLPPTDARFRPDQR--FLEEGNLEAA---ASEKQRVEELQRSR-------------------- -----------------------RRYMEE----------NNLEHIPKFFKKVIDANQR---EAWVSNDTYWELR------ -----------------KDPGFSKVDSPV--LW------------------------------- >MOUSE_OSBPL6 -------------------------------------------------------------------------------- ----------------------------------------------------MSSDEKGISPAHKTSTPTHRSASSSTSS QRESRQS---------------------IHVLERTASSS-TEPSVSRQLLEPEPIPLSKEADSWEIIEGLKIGQ-TNVQK PDRHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKS QDWFDAWVSKLRHHRLYRQNEIVRSPRDASF----------------HIFPATSTAESSPAANVSVVDGKMQPNSFPWQS PLPCSN------SLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQN---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEILQRTQS------------APN-FTDMQANCVDISK-KDKRVTRRWRTKSV SKDTKIQLQEGPPAKGQFNTTRRRQRLAAAVATTVPFSATMSPVRLHSSNPNLCAD-IEFQTPPSHLTDPLESSTDYTKL QEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQVVSEQDHNKGHSTQMARLRQSLSQSEGAGKSW-----------ALNQNA ELRSRLNRIHSESTICDHVVSVNIIPSPDEPGEQIHVSLPLSQQVANESRLSMS--ESVSEFFDAQEVLLS-----ASSS ENEASDDE------------SYISD-----VSDNISEDNTSVADNISRQILNGELTG--GAFRN---------------- GRRTCLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLN-TLQHLCEEMEYSELLDKASE-TDDPYERMVLVAAF AVSGYCSTYFRAGSKPFNPVLGETYECIR--EDKGFRFFSEQVS-HHPPISACHCESKNFVFWQDIRWK--NKFWGKSME ILPVGTLNVTLPKYGDYYVWNKVTTCIHNILSGRRWIEHYG-EVTLRNTKSSVCICKLTFVKVNYWNSNVN-EVQGVVID QEGKVVHRLFGKWHEGLYCGVAPSAK------------------------CIWRPGSLPTNYELYYG------------- FTRFAVELNELDPVLKDLLPPTDARFRPDQR--FLEEGNLEAA---AAEKQRVEELQRSR-------------------- -----------------------RRYMEE----------NNLEHIPKFFKKVIDANQR---EAWVSNDTYWELR------ -----------------KDPGFSKVDSPV--LW------------------------------- >RAT_OSBPL6 -------------------------------------------------------------------------------- ----------------------------------------------------MSSDEKGISPAHKTSTPTHRSALSSTSS QRESRQS---------------------IHVLERTASSS-TEPSISRQLLEPEPIPLSKEADSWEIIEGLKIGQ-TNVQK PDRHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKS QDWFDAWVSKLRHHRLYRQNEIVRSPRDASF----------------HIFPATSTAESSPAANVSVVDGKMQPSSFPWQS PLPCSN------SLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQN---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEILQRTQS------------APN-FTDMQANCVDISK-KDKRVTRRWRTKSV SKDTKIQLQ-------------------------VPFSATMSPVRLHSSNPNLCAD-IEFQTPPSHLTDPLESSTDYTKL QEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHNKGHSTQMARLRQSLSQ-------------------ALNQNA ELRSRLNRIHSESTICDHVVSVNIIPSPDEPGEQIHANLPLSQQVVNESRLSMS--ESVSEFFDAQEVLLS-----ASSS ENEASDDE------------SYISD-----VSDNISEDNTSVADNISRQILNGELTG--GAFRN---------------- GRRTCLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLN-TLQHLCEEMEYSELLDKASE-TDDPYERMVLVAAF AVSGYCSTYFRAGSKPFNPVLGETYECIR--EDKGFRFFSEQVS-HHPPISACHCESKNFVFWQDIRWK--NKFWGKSME ILPVGTLNVTLPKYGDYYVWNKVTTCIHNILSGRRWIEHYG-EVTIRNTKSSVCICKLTFVKVNYWNSNVN-EVQGVVID QEGKVVHRLFGKWHEGLYCGVAPSAK------------------------CIWRPGSLPTNYELYYG------------- FTRFAVELNELDPVLKELLPPTDARFRPDQR--FLEEGNLEAA---AAEKQRVEELQRSR-------------------- -----------------------RRYMEE----------NNLEHIPKFFKKVIDANQR---EAWVSNDTYWELR------ -----------------KDPGFSKVDSPV--LW------------------------------- >COW_OSBPL6 -------------------------------------------------------------------------------- ----------------------------------------------------MSSDEKGISPAHKTSTPTHRSASSSTSS QRDSRQS---------------------IHILERTSSTS-TEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQ-TNVQR PDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKS QDWFDAWVSKLRHHRLYRQNEIVRSPRDASF----------------HIFPSTSTAESSPAANVSVVDGKVQPNSFPWQS PLPCSS------SLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQN---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEILQRTQS------------APN-FTDMQANCVDISK-KDKRVTRRWRTKSV SKDTKIQLQ-------------------------VPFSATMSPVRLHSSNPNLCAD-IEFQTPPSHLTDPLESSTDYTKL QEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHNKGHSTQMARLRQSLSQ-------------------ALNQNA ELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANESRLSMS--ESVSEFFDAQEVLLS-----ASSS ENEASDDE------------SYISD-----VSDNISEDNTSVADNISRQILNGELTG--GAFRN---------------- GRRTCLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLN-TLQHLCEEMEYSELLDKASE-TDSPYERMVLIAAF AVSGYCSTYFRAGSKPFNPVLGETYECIR--EDKGFRFFSEQVS-HHPPISACHCESKNFVFWQDIRWK--NKFWGKSME ILPVGTLNVMLPKYGDCYVWNKVTTCIHNILSGRRWIEHYG-EVTVRNTKSSVCICKLTFVKVNYWNSNVN-EVQGVVMD QEGKVVHRLFGKWHEGLYCGVAPSAK------------------------CIWRPGSMPTNYELYYG------------- FTRFAIELNELDPVLKDLLPPTDARFRPDQR--FLEEGNLEAA---AAEKQRVEELQRSR-------------------- -----------------------RRYMEE----------NNLEHIPKFFKKVIDANQR---EAWVSNDTYWELR------ -----------------KDPGFSKVDSPV--LW------------------------------- >OP0SSUM_OSBPL6 -------------------------------------------------------------------------------- ----------------------------------------------------MSSEEKGISPAHKTSTPTHRSASSSSSS QRESRQS---------------------VHILERNASTG-NEPSASRQLLETEPVSLSKEADSWEIIEGLKIGQ-TNVQK PDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKS QDWFDGWVSKLRHHRLYRQNEIVRSPRDASF----------------HIFPSTSTTESSPAANVAVMDGKVQQNSFPWQP PIPCSN------SLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQN---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEILQRTQS------------APN-FTDMQANCVDISK-KDKRVTRRWRTKSV SKDAKIQLQ-------------------------VPFSATMSPVRLHSSNPNLCAD-IEFQTPPSHLADPLETSTDYTKL QEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHNQGHNPQMARLRQSLSQ-------------------ALNQNA ELRSRLNRIHSESIICDQVVSVNIIPSPDEPGEQIHVSLPLSQQAANESRLSMS--ESVSEFFDAQEVLLS-----ASSS ENEASDDE------------SYISD-----VSDNISEDNTSVADNISRQILNGELTG--GAFRN---------------- GRRTCLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLN-TLQHLCEEIEYSELLDKASE-TDDPYERMVLIAAF AVSGYCSTYFRAGSKPFNPVLGETYECIR--EDKGFRFFSEQVS-HHPPISACHCESKNFVFWQDIRWK--NKFWGKSME ILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYG-EITIRNTKSSICICKLTFVKVNYWNSNVN-EVQGVVMD QEGKVVHRLFGKWHEGLYCGVAPSAK------------------------CIWRPGSMPTNYELYYG------------- FTRFAIELNELDPVLKDLLPPTDARFRPDQR--FLEEGNLEAA---AAEKLRVEELQRSR-------------------- -----------------------RRYMEE----------NHLEHIPKFFKKVIDANQR---EAWVSNDTYWELR------ -----------------KDPGFSKVESPV--LW------------------------------- >PLATYPUS_OSBPL6 -------------------------------------------------------------------------------- ----------------------------------------------------MSSEEKGVSPAHKTSTPTHRSASSSSSS QRESRQG---------------------GYILERNASAG-HEPSVSRQFLENEPVSLSKEADSWEIIEGLKIGQ-TNVQK PDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPMDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKS QDWFDAWVSRLRHHRLYRQNEIVRSPRDASF----------------HIFPSTSTTESSPAANMAMVDGKVQPNSFLWQP PLPCSS------SLPATCTSGQSKVVAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQN---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEILQRTQS------------APN-FTDMQANCVDMSK-KDKRVTRRWRTKSV SKDAKIQLQ-------------------------VPFSATMSPVRLHSSNPNLCAD-IEFQTPPSHLADPLESSTDYTKL QEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDLNKGHSAQMARLRQSLSQ-------------------ALNQNA ELRSRLNRIHSESVICDQVVSVNIIPSPDEPGEQIHVSLPLTQQAANESRLSMS--ESVSEFFDAQEVLLS-----ASSS ENEASDDE------------SYISD-----VSDNISEDNTSVADNISRQILNGELTG--GAFRN---------------- GRRTCLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLN-TLQHLCEEVEYSELLDKASE-TDDAYERMVLIAAF AVSGYCSTYFRAGSKPFNPVLGETYECIR--EDKGFRFFSEQVS-HHPPISACHCESKNFVFWQDIRWK--NKFWGKSME ILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYG-EVTIRNTKSSVCICKLTFVKVNYWNSNVN-EVQGVVMD QEGKVVHRLFGKWHEGLFCGVAPSAK------------------------CIWRPGSMPTNYELYYG------------- FTRFAIELNELDPVLKDLLPPTDARFRPDQR--FLEEGDLEAA---ASEKQRVEELQRSR-------------------- -----------------------RRYMEE----------NHLEHIPKFFKKVTDANQR---EAWVSNDTYWGLR------ -----------------KEPGFSKVESPV--LW------------------------------- >CHICKEN_OSBPL6 -------------------------------------------------------------------------------- ----------------------------------------------------MSSEEKSISPAHKTSTPSHRSASSSSSS QRDRRQS---------------------VNLLERKASSGSTDPSLSKQFLEADPISLSKEPDSWEIIEGLKIGQ-TNVQK PDKHEGFMLKKRKWPLKGWHKRFFVLDNGLLKYSKSPIDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKS QDTFDAWVSKLRHHRLYRQNEIVRSPRDASF----------------HIFPSASTTESSPAANVP--DGKVQQNSFPWQS PIPCSN------SLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQN---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEILQRTQS------------APN-FTDMQANCVDISK-KDKRVTRRWRTKSV SKDAKIQLQ-------------------------VPFSATMSPVRLHSSNPNLCAD-IEFQTPPSHVTDPLECSTEYMKL QEEFCLMAQKVHSLLKSAFNSIAIEKEKLKQIVSEQDLT-GHNAQIAHLRQSLSQ-------------------ALNQNA ELRSRLNRIHSESVICDQVVSVNIIPSPDETGEQIHVSLPLSQQVSNESRLSMS--ESVSEFFDAQEVLLS-----ASSS ENEASDDE------------SYISD-----VSDNISEDNTSVAD-ISRQIVNGELTG--GAFRN---------------- GRRTCLPAPSPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLN-TLQHLCEELEYSELLDKAAE-TDDPYERMVLIAAF AASGYASTYFRAGSKPFNPVLGETYECIR--EDKGFRFFSEQVS-HHPPISACHCESKNFVFWQDIRWK--NKFWGKSME ILPVGTLNVTLPKYGDYYVWNKVTTCIHNILSGRRWIEHYG-EITIRNTKSSVCICKLTFVKVNYWNSNVN-EVQGVVID QEGKVVHRLFGKWHEGLYCGVAPSAK------------------------CVWRPGSMPTNYERYYG------------- FTRFAIELNELDPVLKDLLPTTDARFRPDQR--LLEEGNIEAA---ASEKQRIEELQRSR-------------------- -----------------------RRYMEE----------NSIEYVPKFFKKVIDANQR---EAWVTNETYWELR------ -----------------KDPGFSKVEIPV--LW------------------------------- >ANOLE_LIZARD_OSBPL6 -------------------------------------------------------------------------------- ----------------------------------------------KNLAAKMSSEEKGISPAHKTSTPSHKSASSSSSS QRDSRQS---------------------GHILERNISSGSADLVMGKQLLENEPVIISKEPDNWEIIEGLKIGQ-TNVQK PDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKSPIDTQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKS QDSFDAWVSRLRHHRLYRQNEIVRSPRDASF----------------HIFPSTSTTESSPAANVAMLEAKVSQNNFPWQP PIPCSNSL---SPLPATCTTGQSKVVAWLQDSEEMDRCSEDLAHCQSNLVELSKILQN---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEILQRTQS------------APN-FTDMQANCVD--K-KDKRVTRRWRTKSV SKDAKIQLQEGTTLKSQFSSARRRQRLAAAVATTVPFSSTMSPVRLHSSNPNLCAD-IEFQMPPSHVADPLETSTDYIKL QEEFCLMAQKVHSLLKSAFNSIAIEKEKLKQMVSEHDFT-GHSTQITRLRQSLSQ-------------------ALNQNA ELRSRLNRIHSDSVLCDQVVSVNIIPSPDESGEQIHVSLPLSQQVSHESRLSMS--ESVSEFFDAQEVLLS-----ASSS ENEASDDE------------SYISD-----VSDNISEDNTSVADNISRQILNGELSG--GAFRN---------------- GRRTCLPSPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLN-TLQHLCEELEYSELLDKAAE-SDDPYERMVLIAAF ATSGYASTYYRAGSKPFNPVLGETYESIR--EDKGFRFFSEQVS-HHPPISACHCESKNFVFWQDIRWK--NKFWGKSME ILPIGTLNVTLPKYGDCYVWNKVTTCIHNILSGRRWIEHYG-EITIRNTKSGVCICKLTFMKVNYWNSNVN-EVHGVIMD QEGKVVHRLFGKWHEGLYCGVGPSAK------------------------CIWRPGSMPTNYERYYG------------- FTRFAIELNELDPALKDLLPRTDARFRPDQRQEFLEEGHLEAA---ATEKQRIEELQRSR-------------------- -----------------------RRYLEE----------NHMEHVPRFFKKVIDANQR---EAWVSNDTYWELR------ -----------------KDPGFSKIETLK--LW------------------------------- >ZEBRAFISH_OSBPL6 -------------------------------------------------------------------------------- -------------------------------------MSRHQSRTTSLEEKVATPIHRSTAPLQKSSTPTHKSASSSSSS QRDSRQ-----------------------------------------------------EPDSWEIIEGLRIGQ-THVQR PEKHEGFMLKKRKWPLKGWHKRFFVLDNGILKYSKSPVDIQKGKLHGSIDVGLSVMSIKKRARRIDLDTEEHIYHLKVKS PDVFDLWVCKLRHHRLFRQNEIVRSPRDATL----------------RTFPPSAGAESPQNTPSSTHPKKQGKPSS---- ----FPW-----QLPPSCSNGQSKVAAWLQESEEMDKCAEELAYCQSSLLELNQLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEILQRTQS------------APN-FTDMQSNCVDLSK-KEKRVSRRWRTKSV SKDAKLQQQ-------------------------VPLSASMSQVRLHSSNPNLCAELADFQAPVTRLTDGIDSAGDYIKL QEDFCIIAQKVHSLLKSAFNTVAIEKEKIKQVLLDHEQT-GQSNQIVTLRRSLSQ-------------------ALSQNA ELKTRLNRIHSESVLSEQVVSVNIISSPDEACEPLHVGLPLSQQVSNESRLSMS--ESVSEFFDAQEVLLS-----ASSS ENEASDDE------------SYVSD-----VSDNISEDNASVTDNVSRQMPNGELAS--SMFRN---------------- GRRPCLPAPAPDTSNINLWNILKNNIGKDLSKVSMPVELNEPLN-TLQHMCEELEYTELLDKAAQ-TDDPYERMAIVAAF AVSGYSSTYYRAGSKPFNPLLGETYECIR--EDK--------VS-HHPPISACHCDSQNFTFWQDVRWK--NKFWGKSME ILPIGTVNVMLPSYGDHYEWNKVTTCVHNILSGRRWIEHYG-EVTIRNTRSTTCICKLSFIKGNYWSSNVN-EVQGSVMD QEGRVIHRLFGKWHEGLYCGVPPSAK------------------------CIWRPGSMPTDYELYYG------------- FTRFAVELNELFPEMKELLPPTDARFRPDQR--FLEEGNVQMA---TAEKQRIEEQQRNR-------------------- -----------------------RKWMEE----------NNIKHQPRFFKKVMDSNQR---ERWVSNSMYWELR------ -----------------KDPGFLKLENPE--LW------------------------------- >FUGU_OSBPL6 -------------------------------------------------------------------------------- ----------------------------------------------------LSSEERTPTSINKTSTPVHKSASSSSSS QRDSRQ-----------------------------------------------------EPDSWEIIEGLKIGQ-SNVQR PDKHEGFMLKKRKWPLKGWHKRFFVLDNGILKYSKSPIDIQKGKLHGSIDVGLSVMSIKKRARRIDLDTEEHIYHLKIKS QDIFDAWVSKLRHHRLYRQNEIVRSPRDATM----------------RTFPPPAAVESPQPTLSVVREAKCSNATY---- GTIVQCH-----SNVSHNGNGQSKVVAWLQESEEMDKCAEELARCQSNLTELSRLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEILQRTQS------------APN-FIEMQTNCVEISK-KEKRLNRRWRTKSV GKDAKFQLQ-------------------------VPLSASMSPIRLHSSNPNLCAELVDFQPPVSRLTDSVECSSDYIKL QEEFCTIAQKVHSLLKSAFNTVAIEKEKIKQILSDQEQS-DQSSQINSLRKSLSQ-------------------ALSQNT ELRTRLNRIHSESILTEQVVSVNIISTPDEAEEQM--GIPLTQQASNESRLSMS--ESVSEFFDAQEVLLS-----ASSS ENEGSDDE------------SYVSD-----VSDNISEDNASVTDNISRQMANGDFAG--SAFRN---------------- GRRTCLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLN-TLQRMCEEVEYSELLDKAAD-TEDPFERMVLVAAF AVSGYSSTYYRAGSKPFNPLLGETYECIR--EDKGFCFFSEQVS-HHPPISACHCESKNFTFWQDVRWK--NKFWGKSME ILPIGTVNLTIPRFGDHYEWNKVTTCVHNILSGRRWIEHYG-EITIRNMKSSACLCKLTFIKGNYWSSNVN-EVQGFVMD QEGKVIHRLFGKWHEGLYCGVPPSAK------------------------CVWRPGSMPTDYELYYG------------- FTRFAIELNELCPELKDVLPRTDTRFRPDQR--YLEEGNLEMA---SSEKQRIEDLQRTR-------------------- -----------------------RRWRED----------SNVKQEPCFFKKVVDANHR---ERWVSNNTYWELR------ -----------------KNPGFINMECAVS-LW------------------------------- >STICKLEBACK_OSBPL6 -------------------------------------------------------------------------------- ---------------------------------------------RGVHGRTMSTEERSSPPVLKSSTPVHKSASSSSSS QRDSRQ----------------------FMHLTDLKTLTAQLKSLKHQLCFPQIQRQLQEADSWEIIEGLKIGQ-SNVQR PDKHEGFMLKKRKWPLKGWHKRFFVLDNGILKYSKSPIDIQKGKLHGSIDVGLSVMSIKKRARRIDLDTEEHIYHLKVKS QDIFDAWVSKLRHHRLYRQNEIVRSPREATM----------------RTFPPPAAKESPKPAPSEVREAKAKPSSLPWQP VAPSSNS-----SLPASYSNGQSKVVAWLQESEEMDKCAEELARCQSNLTELSRLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEILQRTQS------------APNSTCVTKTNCVEMSK-KEKRLNRRWRTKSV GKDAKFQLQVQDTQTHSTCKCPLVVS------LQVPLSASMSPVRLHSSNPNLCAELVDFQPPVTRLTDSTECASDYIKL QEEFCTIAQKVHSLLKSSFNTVAIEKEKIKQILSDQEQS-DQSAQINSLRKSLSQ-------------------ALSQNA ELRTRLNRIHSESVLTEQVVSVNIISTPEQAGDQM--GIPLTQQASNESRLSMS--ESVSEFFDAQEVLLS-----ASSS ENEGSDDE------------SYVSD-----VSDNISEDNASVTDNVSRQMANGDFAG--SAFRN---------------- GRRSCLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLN-TLQRMCEELEYSELLDKAAE-TEDPLERMVVVAAF AVSGYSSTYYRAGSKPFNPLLGESYECIR--EDKGFCFFSEQVVSHHPPISACHCESKNFTFWQDVRWK--NKFWGKSME VLPIGTVNLMIPRFGDQYEWNKVTTCVHNILSGQRWIEHYG-EITIRNTKSSACLCKLTFVKGNYWSSNVN-EVQGFVMD QEGKVVHRLFGKWHEGLYCGVPPSAK------------------------CIWRPGSMPTDYELYYG------------- FTRFAIELNELCPELKDVLPRTDARFRPDQR--HLEEGNLEMA---SSEKQRIEDLQRVR-------------------- -----------------------RKCNDE----------NNVKLEPRFFKKVVDGNHR---ERWVSNNTYWELR------ -----------------KNPGFINMESTMN-LW------------------------------- >TETRAODON_OSBPL6 -------------------------------------------------------------------------------- ---------------------------------------------RGPTGRTLSSEERNSTAINKTSTPVHKSASSSSSS QRDSRQQNIE-----------------YLNSTAFGSSVGTTSPSAVREIFQSDLLLQQKEPDSWEIIEGLKIGQ-SHVQR PDKHEGFMLKKRKWPLKGWHKRFFVLDNGILKYSKSPIDIQKGKLHGSIDVGLSVMSIKKRARRIDLDTEEHIYHLKIKS QDIFDAWVSRLRHHRLYRQNEIVRSPREATV----------------RTFPPPAAVESPQPTSSVVREAKQQAKPS---- SLPWQQA-----ALPASYSNGQSKVVAWLQESEEMDKCAEELARCQSSLTELSRLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LEILQRTQS------------APN-FTEMQTNCVEISK-KEKRLNRRWRTKSV GKDAKFQLQPSPPLGVRFSFSLVFLSLYSALCLTVPLSASMSPIRLHSSNPNLCAELVDFQPPISRLTDSVECSSDYIKL QEEFCTIAQKVHSLLKSAFNTVAIEKEKIKQILSDQEQS-DQSAQISSLRKSLSQ-------------------ALSQNT ELRTRLNRIHSESILTEQVVSVNIISTPDEAEEQM--GIPLTQQASNESRLSMS--ESVSEFFDAQEVLLS-----ASSS ENEGSDDE------------SYVSD-----VSDNISEDNASVTDNISRQMANGDFAG--SAFRN---------------- GRRTCLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLN-TLQRMCEELEYSELLDKAAD-TEDPFERMVLVAAF AVSGYSSTYYRAGSKPFNPLLGETYECIR--EDKGFCFFSEQVS-HHPPISACYCESKNFTFWQDMRWK--NKFWGKSME ILPIGTVNLTIPRFGDHYEWNKVTTCVHNILSGQRWIEHYG-EVTIRNTKSSACLCKLTFVKGNYWSSNVN-EVQGFVMD QEGKAIHRLFGKWHEGLYCGVPPSAK------------------------CVWRPGSMPTDYELYYG------------- FTRFAIELNELCPELKDVLPRTDTRFRPDQR--YLEEGNLEMA---SSEKQRIEDLQRTR-------------------- -----------------------RRCRED----------SNSKLEPSFFKKVVDTNHR---ERWVSNNTYWELR------ -----------------KNPGFINMERAVS-LW------------------------------- >HUMAN_OSBPL7 -------------------------------------------------------------------------------- ----------------------------------------------------MDFQERDPPFLPESAQSSKPSSAQQAS- -------------------------------------------------------------ELWEVVEEPRVRLGTEGVM PERQEGHLLKKRKWPLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIYHLKIKS QDLFQSWVAQLRAHRLAHRLDMPRG--SLPS----------------TAHRKVPGAQLPTAATASALPGLGP-------- ---------------------REKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LESLHRIPS------------APVIPTHQASVTTERPK-KGKRTSRMWCTQSF AKDDTIGRV----------------------------------GRLHGSVPNLSRYLESRDSSGTRGL----PPTDYAHL QRSFWALAQKVHSSLSSVLAALTMERDQLRDMHQGSELSRMGVSEASTGQRRLHSL------------------STSSDT TADSFSSLNPEE------------------QEALYMKGRELTPQLSQTSILSLA--DSHTEFFDACEVLLS-----ASSS ENEGSEEEE-----------SCTSE-----ITTSLSEEMLDLR-GAERCQKGG---CVPGRPMG---------------P PRRRCLPAASGPGADVSLWNILRNNIGKDLSKVSMPVQLNEPLN-TLQRLCEELEYSSLLDQASR-IADPCERMVYIAAF AVSAYSSTYHRAGCKPFNPVLGETYECER--PDRGFRFISEQVS-HHPPISACHAESENFAFWQDMKWK--NKFWGKSLE IVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYG-EVLIRNTQDSSCHCKITFCKAKYWSSNVH-EVQGAVLS RSGRVLHRLFGKWHEGLYRGPTPGGQ------------------------CIWKPNSMPPDHERNFG------------- FTQFALELNELTAELKRSLPSTDTRLRPDQR--YLEEGNIQAA---EAQKRRIEQLQRDR-------------------- -----------------------RKVMEE----------NNIVHQARFFRRQTDSSGK---EWWVTNNTYWRLR------ -----------------AEPGYGNMDGAV--LW------------------------------- >MOUSE_OSBPL7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M PERQEGHLLKKRKWPLKGWHKRYFVLEDGILHYATTRQDITKGKVHGSIDVRLSVMSINKKAQRIDLDTEDNIYHLKIKS QDLFHSWVAQLRAHRLAQRLDMP-------S----------------ATHRKAPGTQMLTAGSASALPGVGP-------- ---------------------REKVSSWLRDSDGLDRCSHALSECQGKLQELHRLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LESLHRIPS------------APVIPTHQTSVTTERPK-KGKRTSRMWCTQGF AKDDTIGRV----------------------------------GRLHGSVPNLSRYLESRDTSGPRGL----PPPDYAHL QRSFWALAQKVHNSLSSVLVALTTERDRLRDLHQGSELSRMVVSEAPDGQRRLHSL------------------SISSDT TADSFSSLNPEE------------------QEALYMKGRELTPQLSQSSVLSLA--DSHTEFFDACEVLLS-----ASSS ENE-VREEG-----------SCASE-----ITTSLSEEVLDIR-GADRYQKGP---CVPGIAVG---------------P PRRRCLPAASGPGTDVSLWNILRNNIGKDLSKVSMPVQLNEPLN-TLQRLCEELEYSSLLDQASR-MADPCERMVYIAAF AVSAYSSTYHRAGCKPFNPVLGETYECER--PDRGFRFISEQVS-HHPPISACHAESENFIFWQDMKWK--NKFWGKSLE IVPVGTVNVSLPRFGDHFEWNKVTSCIHNILSGQRWIEHYG-EVLIRNTQDSSCHCKITFCKAKYWSSNIH-EVQGAVLS RSGRVLHRLFGKWHEGLYRGPPPGGQ------------------------CIWKPNSMPPDHERNFG------------- FTQFALELNELTSELKRTLPSTDTRLRPDQR--YLEEGNIQAA---EAQKRRIEQLQRDR-------------------- -----------------------RRVMEE----------NNIVHQARFFRRQTDSSGK---EWWVTNHTYWRLR------ -----------------AEPGYGNLDGAV--LW------------------------------- >RAT_OSBPL7 -------------------------------------------------------------------------------- ----------------------------------------------------MDFQERDTPSLAESTQSSKPSSTQQAS- -------------------------------------------------------------ELWEVVEEPRGRLGAEDIM PERQEGHLLKKRKWPLKGWHK------------------ITKGKVHGSIDVRLSVMSINKKAQRIDLDTEDNIYHLKIKS QDLFQSWVSQLRAHRLAQRSDLP-------N----------------ATHRKAPGTQTLTAGSASALPGVGP-------- ---------------------REKVSSWLRDSDGLDRCSHALSECQGKLQELHRLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LESLHRIPS------------APVIPTHQASVTTERPK-KGKRTSRMWCTQGF AKDDTIGRV----------------------------------GRLHGSVPNLSRYLESRDTSGPRGL----PPPDYAHL QRSFWALAQKVHNSLSSVLVALTTERDRLRDLHQGSELSRMAVSEAPDGQRRLHSL------------------SISSDT TADSFSSLNPEE------------------QEALYRKGRELTPQLSQSSVLSLA--DSHTEFFDACEVLLS-----ASSS ENEGSEEEE-----------SCASE-----ITTSLSEEVLDIR-GADRYPKGA---CVPGIAVG---------------P PRRRCLPAASGPGTDVSLWNILRNNIGKDLSKVSMPVQLNEPLN-TLQRLCEELEYSSLLDQASR-MADPCERMVYIAAF AVSAYSSTYHRAGCKPFNPVLGETYECER--PDRGFRFISEQVS-HHPPISACHAESENFIFWQDMKWK--NKFWGKSLE IVPVGTVNVSLPRFGDHFEWNKVTSCIHNILSGQRWIEHYG-EVLIRNTQDSSCHCKITFCKAKYWSSNIH-EVQGAVLS RSGRVLHRLFGKWHEGLYRGPPPGGQ------------------------CIWKPNSMPPDHERNFG------------- FTQFALELNELTAELKRTLPSTDTRLRPDQR--YLEEGNIQAA---EAQKRRIEQLQRDR-------------------- -----------------------RRVMEE----------NNIVHQARFFRRQTDSSGK---EWWVTNHTYWRLR------ -----------------AEPGYGNLDGAV--LW------------------------------- >COW_OSBPL7 -------------------------------------------------------------------------------- ----------------------------------------------------MDFQEWDPPSLAESTQSAKPSGAQQAS- -------------------------------------------------------------ELWEVVEEPRGRLGAEGIM PERQEGHLLKKRKWPLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIYHLKIKS QDLFQSWVAQLRAHRSAQHLDVPRS--LLPS----------------TAHWKVTGAQPAVSGSASALPGVGP-------- ---------------------REKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LESLHRIPS------------APVIPTHQASVTTERPK-KGKRTSRMWCTQSF AKDDTIGRV----------------------------------GRLHGSVPNLSRYLESRDPSGPRGL----PPPDYAHL QRSFWALAQKVHSSLSSVLAALTAERDRLRDLHPGSEPSRLGVSETSAGPRRLHSL------------------SISSDT TADSFSSLNPEE------------------QEALYMKGRELTPQLSQSSVLSLA--DSHTEFFDACEVLLS-----ASSS ENEGSEEEE-----------SCTSE-----VTTSLSEEVLDLR-GAERCQKEGQATCVPGAAVG---------------P PRRRCLPAASGPGTDVSLWNILRNNIGKDLSKVSMPVQLNEPLN-TLQRLCEELEYSSLLDRASR-TADPCERMVYIAAF AVSAYSSTYHRAGCKPFNPVLGETYECER--PDRGFRFISEQVS-HHPPISACHAESENFIFWQDMKWK--NKFWGKSLE IVPVGTVNVSLPRFGDHFEWNKVTSCIHNILSGQRWIEHYG-EVLIRNTQDSSCHCKLTFCKAKYWSSNVH-EVQGAVFS RSGRVLHRLFGKWHEGLYRGPPPGGQ------------------------CIWKPNSMPPNYERNFG------------- FTQFALELNELTAELKRSLPSTDTRLRPDQR--YLEEGNIQAA---EAQKRRIEQLQRDR-------------------- -----------------------RKVMEE----------NNIVHQARFFRRQTDSSGK---EWWVTNNTYWQLR------ -----------------AEPGYGNLDGAV--LW------------------------------- >HORSE_OSBPL7 -------------------------------------------------------------------------------- ----------------------------------------------------MDFQERVPPSLAVSTQSAKPGSVQQVS- -------------------------------------------------------------ELWEVVEEPRGRLGAEGIM PERQEGHLLKKRKWPLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIYHLKIKS QDLFQSWVAQLRAHRLAQRLDMPRG--SLPS----------------TTHRKAPGAQLPTASGASALPGVGS-------- ---------------------REKVSSWLRDNDGLDRCSHELSECQGKLQELHRLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LESLHRIPS------------APVIPTHQASVTTERPK-KGKRTSRMWCTQSF AKDDTIGRV----------------------------------GRLHGSVPNLSRYLESRDPSGSRGL----PPPDYAHL QRSFWALAQKVHSSLSSVLAALTAERDRLRDLHQGSELSRMGVSEASAGPRRLHSL------------------SISSDT TADSFSSLNPEE------------------QEALYMKGRELTPQLSQSSILSLA--DSHTEFFDACEVLLS-----ASSS ENEGSEEEE-----------SCTSE-----VTTSLSEEVLDLR-LAERCQKGG---CVPGRAAG---------------P PRRRCLPAASGPGADVSLWNILRNNIGKDLSKVSMPVQLNEPLN-TLQRLCEELEYSSLLDQASR-ITDPCERMVYIAAF AVSAYSSTYHRAGCKPFNPVLGETYECER--PDRGFRFISEQVS-HHPPISACHAESENFIFWQDMKWK--NKFWGKSLE IVPVGTVNVSLPRFGDHFEWNKVTSCIHNILSGQRWIEHYG-EVLIRNTQDSSCHCKITFCKAKYWSSNVH-EVQGAVFS RSGRVLHRLFGKWHEGLYRGPPPSSQ------------------------CIWKPNSMPPDHERNFG------------- FTQFALELNELTAELKRSLPSTDTRLRPDQR--YLEEGNIQAA---EAQKRRIEQLQRDR-------------------- -----------------------RRVMEE----------NNIIHQARFFRRQTDSSGK---EWWVTNNTYWRLR------ -----------------AEPGYGNLDGAV--LW------------------------------- >OPOSSUM_OSBPL7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------MGTTGL- -------------------------------------------------------------ELWELVEEPQGRLGTEGTQ PGRQEGPLLKKRKWPLKGWHKRYFVWDLPMLFNSSRNVSYAKGKLHGSIDVRSSVMSINKKAQRIDLDTEDNIYHLKIKS QELFQSWVARLCAHRMAQRPDMARCPKLPAS----------------STNRKTSSARLAST---DNMPALGS-------- ---------------------QDKVSTWLKDSEGLDRCSHELSECQGKLQELHKLLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LESLHRIPS------------APVISTNQ------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------QEALYMKGRELTPQLSQRSVLSLA--DSHTEFFDACEVFLS-----ASSS ENEGSEEE------------SCTSE-----VTTSLSEEVLDIG-STEHCQKGA----SPGGAGV---------------P PRRRCLPAASGPGTDVSLWNILRNNIGKDLSKVSMPVQLNEPLN-TLQRLCEELEYSNLLDQASR-TPDPCERMLYIAAF AVSAYSSTYHRAGCKPFNPVLGETYECER--PDRGFRFISEQVS-HHPPISACHAESDNFIFWQDMKWK--NKFWGKSLE IVPVGTVNVRLPRFGDHFEWNKVTSCIHNILSGQRWIEHYG-EVLIRNTQDSSCHCKITFCKAKYWSSSVH-EVQGAVFS RSGRVIHRLFGKWHEGLYRGPPPGGQ------------------------CIWKPNLMPQDHERNFG------------- FTQFALELNELTAELKRSLPSTDTRLRPDQR--YLEEGNIQAA---ESQKRRIEQLQRDR-------------------- -----------------------RKVMEE----------NNITHQARFFRRQTDGNGK---EWWVTNNTYWRLR------ -----------------AEPGYGNLDGAV--LW------------------------------- >ANOLE_LIZARD_OSBPL7 -------------------------------------------------------------------------------- ------------------------------------------------------------------------------S- -------------------------------------------------------------ESWEVVDELQIQGGVIQE- PERQEGYLLKKRKWPLKGWHKRYFVLEDGILKYATTRQDVLKGKLHGSIDVRLSVMSVNKKAQRVDLDTEDNIYHLKIKS QELFNNWVAKLCSHRQAEKFLMGKMD--FPN----------------TLNHGNARHRILMSESAPALSSMGSH------- ---------------------RDKVNSWLSDSKGLDRCSAELTECQEKLQELNRMLQS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------LDSLHRIPS------------APLISNSQTSTSTERPR-KGKRSTRIWCTQSF AKDDTIGRV----------------------------------GRLHGSVPNLSRYLESCQNQAIFSV----PP-EYSQL QRSFWILAQKVHGSLTSVLAVLSAERGRLQELQQTLDLQRLTLDN-PECIRRFHSL------------------SISSDT TLDSFASFNPDEP-----------------NNTLLVKSQEQ--QLSNRSIVSLS--DSHTEFFDACEVFLS-----ASSS ENEATDDE------------SCVSE-----VTNSISEEMAEVAGGPGRYTSGS----QPGKGPG---------------I MRRNCLPASHVHASDVSVWNILRNNIGKDLSKVSMPVQLNEPLN-TLQRLCEELEYSALLDAASR-TLDPCERLICMAAF AVSAYASTYFRAGSKPFNPVLGETYECVR--PDKGFRFISEQVC-HHPPVSACHAESDNFVFWQDMKWK--NKFWGKSLE IIPVGTVNVHLPRFGDHYEWNKVTSCIHNILSGQRWIEHYG-EVLIRNTRDSTYHCKLTFCKARYWGSGVN-EVQGAILS HSGKVIHRLFGKWHDGLYRGVAPVGK------------------------CIWRPNPMPRDYEKNYG------------- FTQFALELNELTPELKRLLPSTDTRLRPDQR--YLEEGNAQAA---ESQKRRIEQLQRDR-------------------- -----------------------RRVMDD----------NNILHQARFFRRQVDANGK---ESWVSNSSYWKLR------ -----------------GEPGFSNMDSAV--LW------------------------------- >HUMAN_OSBPL8 ----------------------------MEGGLADGEPDRTSLLGDSKDVLGPSTVVANSDESQLLTPGKMSQRQGKEAY PTPTKDLHQ-----------PSLSPASPHSQGFERGKEDIS------------QNKDESSLSMSKSKSESKLYNGSEKDS STSSK--------------------------------------------LTKKESLKVQKKNYREEKKRATKELLSTITD PSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNGQ--WVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAV KGPKGEAVG-SITQPLPSSYLIIRATS---------------ESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSVSS DSTH-----------VTFYGLLRANNLHSGDNFQLNDSEIERQHFKDQDMYSDKSDKEN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------DQEHDESDNEVMGKSEESDTDTSERQDDS YIEP-------------------------------------EPVEPLKETTYTEQS-HEELGEAGEASQTETVSEENKSL IWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALE------------------------------- ------------------------------ENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIH---PRTN SKTFYIAEQ---------------------VSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGN---------------- -SLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGK LKLGKEVLATLEGHWDSEVFITDKKT------DNSEVFWNPTPDIKQWRLIRHTVKFE----EQGDFES--EKLWQRVTR AINA-KDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLFELD------PLTGEWHYKFADTRPWDPLN----DMIQFE KDGVIQTKVKHR-TPMV------------------------------------SVPKMKHKPTRQ--------------- -QKKVAKGYSSPEPDIQDSSGSEAQSVKPSTR-RKKGIELG------DIQSSIESIKQTQ-------------------- -----------------------EEIKRN---------IMALRN------HLVSSTP--------ATDYFLQQK------ ---------------DYFIIFLLILLQVIINFMFK----------------------------- >MOUSE_OSBPL8 ----------------------------MEAALADGEPDRSSLLGDSKDVLGPSTVVANSDEPQHLTPGKMSQRQGRDAN PTPTRDLPQ-----------PSLSPASLHSQGFERGKEDIS------------QNKDDSSLSMSKSKSESKLYNGSEKDS STSSK--------------------------------------------LTKKESLKVQKKNYREEKKRATKELLSTITD PSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNGQ--WVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAV KGPKGEAVG-SITQPLPSSYLIIRATS---------------ESDGRCWMDALELALKCSSLLKRTMVREGKEHDLSISS DSTH-----------VTLYGLLRANNLHSGDNFQLNDSEIERQHFKDQDLYSDKSDKEN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------DPEHDESDNEVLGKSEESDTDTSERQDDS YIDP-------------------------------------EPVEPLKETTYMEQS-HEELGEAGEASQTETVSEENKSL IWTLLKQVRPGMDLSRVVLPTFILEPRSFLDKLSDYYYHADFLSEAALE------------------------------- ------------------------------ENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIH---PRTN SKTFYIAEQ---------------------VSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGN---------------- -SLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDYVNQISGK LKLGKEVLATLEGHWDSEVFINDKKT------DNSEIFWNPTPDIKQWRLIRHTVKFE----EQDDFES--EKLWQRVTK AINA-KDQTEATQEKYVLEEAQRQAARDRKTKTQEWVCKLFELD------PLTGEWHYKFSDTRPWDPLN----DMIQFE KDGVIQTKVKHR-TPMV------------------------------------SVPKMKHKPTRQ--------------- -QKKVVKGYSSPEPDIQDSSGSEAQSVKPSTR-RKKGIDLG------DIQSSIESIKQTQ-------------------- -----------------------EEIKRN---------IMALRN------HLLSSTP--------ATDYFLQQK------ ---------------DYFVIFLLILLQVIINFIFK----------------------------- >HORSE_OSBPL8 ----------------------------MEAGLADGEPDRTSLLGDSKDVLGPSTVVANSDESQLLTPGKMSQRQGKEAY PVPTRDSYQ-----------PSFSPASPHSQGFERTKEDIS------------QNKDESSLSMSKSKSESKLYNGSEKDS STSSK--------------------------------------------LTKKESLKVQKKNYREEKKRATKELLSTITD PSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNGQ--WVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAV KGPKGEAVG-SITQPLPSSYLIIRATS---------------ESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSISS ESTH-----------VTLYGLLRANNLHSGDNFQLNDSEIERQHFKDQDMYSDKSDKEN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------DQEHDESDNEVMGKSEESDTDTSERQDDS YIEP-------------------------------------EPVEPLKETTYTEQS-HEELGEAGEASQTETVSEENKSL IWTLLKQVRPGMDLSRVVLPTFILEPRSFLDKLSDYYYHADFLSEAALE------------------------------- ------------------------------ENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIH---PRTN SKTFYIAEQ---------------------VSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGN---------------- -SLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAVLEFKLKPFLGSSDCVNQISGK LKLGKEVLATLEGHWDSEVFINEKKT------DNSEVFWNPTPDIKQWRLIRHTVKFE----EQEDFES--EKLWQRVTR AINA-KDQTEATQEKYVLEEAQRQAARDRKTKNEEWTCKLFELD------PLTGEWHYKFADTRPWDPLN----DMIQFE KDGVIQTKVKHR-TPMV------------------------------------SVPKMKHKPTRQ--------------- -QKKVAKGYSSPEPDIQDSSGSEAQSLKPSTR-RKKGIELG------DIQNSIESIKQTQ-------------------- -----------------------EEIKRN---------IMALRN------HLVSSTP--------ATD-FLQQK------ ---------------DYFIIFLLILLQVIINFMFK----------------------------- >OPOSSUM_OSBPL8 ------------------------MVLELSFNLDSDSWTTSLHVGDAKDVHGPSTLVTNNDDSHLLTSAKMNQRQGKEAY LTPTKDLLQ-----------PSLSPGSAHSQGFERGKDDLS------------QNREETSHSMSKSKSESKLYNGSEKDI SSSSK--------------------------------------------LTKKESLKVQKKNYREEKKRATKELLSTITD PSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNGQ--WVGTVLLNACELIERPSKKDGFCFKLFHPLEQSIWAV KGPKGEAVG-SITQPLPSSYLIIRATS---------------ESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSMSS ENSH-----------VTFYGLLRANNLHSGDNFQLNDSEIERQHFKDQDMYSDKSDKEN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------DQEHDESDNEGIGKSEESDTDTSERQDDS YIDP-------------------------------------EPTEVLKETTYTEQG-QEELGEAGEASQTETVSEENKSL IWTLLKQVRPGMDLSRVVLPTFILEPRSFLDKLSDYYYHADFLSEASLE------------------------------- ------------------------------ENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWVH---PRTN SKTFYIAEQ---------------------VSHHPPISAFYISNRKDGFCLSGSILAKSKFYGN---------------- -SLSALLEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAVLEFKLKPFLGSSDCVNQISGK LKLGKEVLATLEGHWDSEVIIHDKKT------DSSEVFWNPTSEIKQRRLIRHTVKFE----EQEPFES--EKLWQRVTR AINV-KDQTEATQEKYVLEEAQRKAARERKGKNEEWICKLFELD------AATGEWHYRYSDTRPWDPLN----DLIQFE KDGVIQTKVRHR-TPMV------------------------------------SVPKMKHKPSRQ--------------- -PKKAGKGYSSPELDIQDSSGSEAQVLKPSSR-RKKTVDLG------DLQCSIDCIKQTQ-------------------- -----------------------EEIKRS---------IVALRN------HLISSSS--------VTDTFLQPR------ ---------------DYFIIFLLILLQIIINFMFK----------------------------- >CHICKEN_OSBPL8 -------------------------MADIDVFDRRYAVESLLMLGRRLPHVQNFAVVTNSDESQLLTPGKMSQRQGKEAY FTPTKELLQ-----------PSLSPATAHSHGFDKGKDEAS------------QSKEDTAHSMSKSKSESKLFNGSEKDI SLSSS-------------------------------------------KLTKKESLKVQKKNYREEKKRATKELLSTITD PSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLVYKTPKNGQ--WVGTVLLNACELIERPSKKDGFCFKLFHPLEQSIWAI KGPKGEAVG-SITQPLPSSYLIIRAAS---------------ESDGRCWMDALELALKCSSLLKRTMIREGKEHDLNSSS DSAH-----------VSLYGLLRANNLNSGDNLPLNDSEIERHHFKDQDMYSDKSDKEN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------DHEHDESDNDGLGKSEESDSDTSERQDDS YVDP-------------------------------------EPID-IKETTYLEQS-HEELGEAGEAAQTEVVSEENKSL IWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALE------------------------------- ------------------------------ENAYNRMKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCMWIH---PRTN SKTFYIAEQ---------------------VSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGN---------------- -SLSAILDGEGRLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCEKTGYSATIEFKLKPFLGNNDSVNQISGK IKLGKEVLAILEGHWDSEVTIRDKKT------DVSETFWNPTSDIKQRRLPRYTVKFE----EQDDFES--EKLWQQVTK AINN-KDQTEATQEKYVLEEAQRKSAKERKLKGEEWTCKLFDQD------SVTGEWHYRYADTRPWDPLN----DMIQFE KDGTIQTKVRHR-TPMV------------------------------------TVPKIKRKPTG---------------- -QKKGECGFSSPEPDNQDSSGSEAQLTKHNTRIRKKGADLG------ELQSAIESIKETQ-------------------- -----------------------EDIKRD---------IMALRN------RVTSNSPP-------VDNQFLQLK------ ---------------HYIFILLLVLLQLIINFLFK----------------------------- >ANOLELIZARD_OSBPL8 -------------------------------------------------------------------------------- -------------------------------GFDRGKDDAS------------QGKDDSSQSMSKSKSESKLYNGSEKDI AAASTTT-------------------------------------SSTTKLTKKESLKVQKKNYREEKKRATKELLSTITD PSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTPKNGQ--WVGTVLLNACELIERPSKKDGFCFKLFHPLEQSIWAV KGPKGEAVG-SITQPLPSSYLIIRAAS---------------ESDGRCWMDALELALKCSSLLKRTMIREGKEHEPN-LT DGAH-----------VSFYGLLRANNVHSSESFPLNDSEIERHHFKDPDLYSDKSDREN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------DHDRDESDNDALG---ESDSDTSERQDDS YIDP-------------------------------------EPDH-VKETTYIEEA-HEELGEAGEASQTETVSEENKSL IWTLLKQVRPGMDLSKVVLPTFILETRSFLDKLSDYYYHADFLSEAALE------------------------------- ------------------------------ENAYNRMKQVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWVH---PKTN SKTFYIAEQ---------------------VSHHPPISAFYVSNRKDGFCLSGNILAKSRFYGN---------------- -SLSAILEGEGRLLFLNRGEEYIMNMPYAHCKGILYGTLTLELGGTVNIACEKTGYSAALEFKLKPFLGNNDNVNQIMGK IKLGKEVLATLEGHWDSEVFIRDKKT------GISATFWNPTSEIRQCRLRRHTVKFE----EQSDFES--AKLWQHVTR AINN-KDQAEATQEKYVLEEAQRKSAKERKAHDEEWICRLFEPD------PLTGEWIYRYADTRPWDPLN----DMIQFE KGGAIQTKVKHR-TPMV------------------------------------SVAKIKRSAK----------------- -SKKGECGFSSPEPDNQDSSGSEAQLT-HSTRVRKKTLDLI------ELQSAIESIRETQ-------------------- -----------------------EDIRRD---------ITALRT------RMSTSPPP-------QDNTFFQFK------ ---------------HYVFILLMILLQLMINYLFK----------------------------- >FROG_OSBPL8 -------------------------------MKEEGPLRRRSCAG-----VSPGTFLPRPDGRKLVRNASFGGYN----- ---------------------ELSPALP---GFDKGKDEVL------------QSKEDTSISMSKSKSESKLYNGSERDI ASASS-------------------------------------------KLTKKESLKVQKKNYREEKKRATKELLSTITD PSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTPKNGQ--WVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAV KGPKGEAVG-SITQPLPSSYLIIRAAS---------------ESDGRCWMDALELALKCSSLLKRTMIREGKEHDLNSSA DNSH-----------VGFYGLLRVNNLHSNENFQLNDSEIERHHFKDQDTYSDKSDKDN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------DHDHDESDNDGLGKSEESDSDTSERQDDS FVDP-------------------------------------DPPELIKETTYVEEA-HEELGEAGEASQTETVSEEHKSL IWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALE------------------------------- ------------------------------ENPYSRMKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIH---PRTS SKTFYISEQ---------------------VSHHPPVSAFYVSNRKDGFCLSGSILAKSKFYGN---------------- -SLSALLEGEGRLTFLNRGEDYLMTMPYAHCKGILYGTMTLELGGSVTITCEKTSYSATLDFKLKPFLGSDDSVNQISGK IKLGKEVLATLEGHWDSEVFIHDKKT------DVFETFWNPTLEIRHHRLIRCTVNQE----EQGEFES--ERLWRLVTL AINN-KDQTEATQEKFVLEEAQRKAAKERKAKGEEWTCKLFEQD------PLTGEWHYKYADTRPWDPLN----DLIQFE NDGVIQTKVRHR-TPMV------------------------------------CVPKLKHKASGQ--------------- -QKKGESGCSSPELDNQDSSGSEAHLLSHNNRVRKKGADHG------ELQSAIDSIKKTQ-------------------- -----------------------EEINRN---------IIALRN------RVSVNTSS-------TENSFLQQR------ ---------------DYFIIFFLITLQIAVSYLFK----------------------------- >MEDAKA_OSBPL8 ---------------------------MDSSSESQTEPEKTLHNAESREHHAALAAVASGDEPGLLTPGRMSQRQVKEKD REREKEAGLQTPSREHMASPSALSPGVSYSHGFERGKEDLLP-----------LPLKEDSNSISKSKSETKLYNGSDKDV PGSGG-------------------------------------------KLTKKESLKVQKKNYREEKKRATKELLSTITD PSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTHKNGQ--WVGTVLLNACELIERPSKKDGFCFKLFHPLEQSIWAV KGPKGEAVG-SITQPLPSSHLIFRAAS---------------ESDGRCWMDALELALKCSSLLKRTMIREGKEDMSAVST SGEHS----------INFYSLLRAHNLHG---FQFNDS----DHLKDPDLYSDKSDREG--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------EPDHEESDPEGLE---ESDSDTSERQDDS YIDL-------------------------------------DANEHLLETLYQEQS-HEELGEA----QTETVSEENKSL IWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAAVE------------------------------- ------------------------------ENAYNRLKKVVKWYISGFYKKPKGLKKPYNPIIGETFRCLWLH---QNTN SKTFYIAEQ---------------------VSHHPPVSAFYVSNRKDGFCLSGSILAKSKFYGN---------------- -SLSAILDGEARLTFLNRGEDYVMNMPYAHCKGILYGTMTLELGGQITIACEKTGYSAQLEFKLKPFLGSSDCVNQISGK IKLGKEVLATLEGHWDSEIFINDKKT------GTMDTFWNPTSELRQSRLIRCTVPLE----EQSEFES--ERLWQQVTR AINN-KDQT