>Homo_sapiens_GADD45A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEEFSAG-EQKTE--------- ------------------------------RMDKVGDALEEV-----------------------LSKALSQR------T ITVG--------VYEAAKLLN----------------------------------------VDP---------------D NVVLCLLAADEDDDRDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVS-------------------NPGRLAEL LLLETD--------------------------------------------------------------------AGPAAS EGAEQPPDLHCVLVT--------NPHSSQWKDPALSQLICFCRESRYMDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Pan_troglodytes_GADD45A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEEFSAG-EQKTE--------- ------------------------------RMDKVGDALEEV-----------------------LSKALSQR------T ITVG--------VYEAAKLLN----------------------------------------VDP---------------D NVVLCLLAADEDDDRDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVS-------------------NPGRLAEL LLLETD--------------------------------------------------------------------AGPAAS EGAEQPPDLHCVLVT--------NPHSSQWKDPALSQLICFCRESRYMDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Macaca_mulatta_GADD45A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEEFSAG-EQKTE--------- ------------------------------RMDKVGDALEEV-----------------------LSKALSQR------T ITVG--------VYEAAKLLN----------------------------------------VDP---------------D NVVLCLLAADEDDDRDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVS-------------------NPGRLAEL LLLETD--------------------------------------------------------------------AGPAAT EGAEQPPDLHCVLVT--------NPHSSQWKDPALSQLICFCRESRYMDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Mus_musculus_GADD45A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEEFSAA-EQKTE--------- ------------------------------RMDTVGDALEEV-----------------------LSKARSQR------T ITVG--------VYEAAKLLN----------------------------------------VDP---------------D NVVLCLLAADEDDDRDVALQ---------------------------------------IHFTLIRAFCCEND------- ----------------------------------------------INILRVS-------------------NPGRLAEL LLLEND--------------------------------------------------------------------AGPAES GGAAQTPDLHCVLVT--------NPHSSQWKDPALSQLICFCRESRYMDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Oryctolagus_cuniculus_GADD45A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEEFSAG-EQKTE--------- ------------------------------RMDKVGDALEEV-----------------------LSKALSQR------T ITVG--------VYEAAKLLN----------------------------------------VDP---------------D NVVLCLLAADEDDDRDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVS-------------------NPGRLAKL LLLETD--------------------------------------------------------------------ASPAAS EGAAQPPDLHCVLVT--------NPHSSQWKDPALSQLICFCRESRYMDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Canis_familiaris_GADD45A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEEFSAA-EQKSE--------- ------------------------------RMDKVGDALEEV-----------------------LSKALSQR------T ITVG--------VYEAAKLLN----------------------------------------VDP---------------D NVVLCLLAADEDDDRDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------IDILRVS-------------------NPGRLAEL LLLEPH--------------------------------------------------------------------AGP-AS EGAEQPPDLHCVLVT--------NPHSSQWKDPALSQLICFCRESRYMDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Bos_taurus_GADD45A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEEFSAG-EQKTE--------- ------------------------------RMDKVGDALEEV-----------------------LSKALSQR------T ITVG--------VYEAAKLLN----------------------------------------VDP---------------D NVVLCLLAADEDDDRDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------IDILRVS-------------------NPGRLAEL LLLETD--------------------------------------------------------------------AGPAAS EGAEQPPDLHCVLVT--------NPHSSQWKDPALSQLICFCRESRYMDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Dasypus_novemcinctus_GADD45A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEEFSAG-EQKTE--------- ------------------------------RMDKVGDALEEV-----------------------LSKALSQR------T ITVG--------VYEAAKLLN----------------------------------------VDP---------------D NVVLCLLAADEDDDRDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVS-------------------NPGRLAEL LLLETG--------------------------------------------------------------------TGPAAS EGAEQPPDLHCVLVT--------NPHSSQWKDPALSQLICFCRESRYMDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Monodelphis_domestica_GADD45A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEEFAAG-EQKPE--------- ------------------------------GMDKVGDALEEV-----------------------LSKALSQR------S ITVG--------VYEAAKLLN----------------------------------------VDP---------------D NVVLCLLAADEDDDRDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVS-------------------NPGRLAEL LLLGTGGP-----------------------------------------------------------------ASAAAAA AAAEQPPDLHCVLVT--------NPHSSQWKDPALSQLICFCRESRYMDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Gallus_gallus_GADD45A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEELPGD-QRTAG--------- ------------------------------RMEQAGDALEEV-----------------------LSKALSQR------S LTLG--------VYEAAKLLN----------------------------------------VDP---------------D NVVLCLLAADEEEEGDAALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVS-------------------NPARLAQL LLPDGG-------------------------------------------------------------------------- --PEPPTDLHCVLVT--------NPHASQWKDPALSQLMCFCRESRYMDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Anolis_carolinensis_GADD45A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEELAGE-HQALG--------- ------------------------------SMEKVGDALEEV-----------------------LSKALTQR------S ITVG--------VYEAAKLLN----------------------------------------VDP---------------D NVVLCLLAADEEDNQDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVS-------------------NPSRLAEL LLLGAG-------------------------------------------------------------------------G GGGEPPADLHCVLVT--------NPHASQWKDPALSQLICFCRESRYMDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Xenopus_tropicalis_GADD45A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------QYNMTLEEQLSG-DQSIG--------- ------------------------------KMESVGNALEEV-----------------------LCKAKLQR------T ITIG--------VYEAAKLLN----------------------------------------VDP---------------D NVVLCLLATDDTYDQDIALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVS-------------------NMSRLAEI LG----------------------------------------------------------------------------GS DKPGEPADLHCILIN--------SPHELQVKDPALKEVICYCKESRYLDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Danio_rerio_GADD45A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTFEEPCGD-NATE---------- ------------------------------RMDSVEKALEEV-----------------------LTAALPQG------C ITVG--------VYEAAKSLN----------------------------------------VDP---------------D NVVLCLLATDEEDVKDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVN-------------------NMRRLAEI LEGMKP-------------------------------------------------------------------------- --GGESMDLHCVLVT--------NPQSSTWKDPALSKLNRFCRDSRGLDQWVPV-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Danio_rerio_GADD45A_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTFEELNGD-YSIE---------- ------------------------------RMNSVIKALEEV-----------------------LRSALPQG------C ITVG--------VYEAAKSLN----------------------------------------VDP---------------D NVVLCILATDDDDVKDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVN-------------------NTRRLANI LG-GAG-------------------------------------------------------------------------- MHGSEQMDLHCILVT--------VPHASTWKNPALGKVNRFCRESRCMDQWVPI-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Takifugu_rubripes_GADD45A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTFEELNGD-YSQES--------- ------------------------------RMDSVAKALEEV-----------------------LTSALPQG------C ITVG--------VYEAAKSLN----------------------------------------VDP---------------D NVVLCILATDDEDVQDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVN-------------------NTRRLAEI LGGGSG-------------------------------------------------------------------------K QSGGEPMDLHCVLVT--------SPHSTLWKDPALSKVNRFCRESRCMDQWVPI-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Tetraodon_nigroviridis_GADD45A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTFEELGAD-YSQE---------- ------------------------------RMDSVARALEEV-----------------------LTSALPQG------C ITVG--------VYEAAKSLN----------------------------------------VDP---------------D NVVLCILATDDEDVQDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVN-------------------NTRRLAEI LGGGNG-------------------------------------------------------------------------K QSGGEPLDLHCVLVT--------SPHSTSWKDPALGKVNRFCRESRCMDQWVPI-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Gasterosteus_aculeatus_GADD45A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTFEELSGD-FSQE---------- ------------------------------RMDSVAKALEEV-----------------------LTSALPQG------S ITIG--------VYEAAKSLN----------------------------------------VDP---------------D NVVLCILATDDEDVKDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVN-------------------NTQRLAEI LGGAAGG------------------------------------------------------------------------K QSGGEPMDLHCVLVT--------SPHSTSWKDPALSKVNRFCRESRCMDQWVPI-------INLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Gasterosteus_aculeatus_GADD45A_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTFEETSGD-NSSE---------- ------------------------------RMESVAEALEEV-----------------------LSSAVPQG------C TTVG--------VYEAAKSLN----------------------------------------ADP---------------D NVVLCLLATDDE--EDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVS-------------------NLQRLAEI LGGGKA-------------------------------------------------------------------------- --GGEPTDLHCVLVT--------NPQSSLWKDPALSKVTRFCRESRCLDQWVPV-------INLPDR------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Oryzias_latipes_GADD45A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------MDSVAKALEEV-----------------------LTSALPQG------A ITVG--------VYEAAKSLN----------------------------------------VDP---------------D NVVLCVLATDEDDVKDVALQ---------------------------------------IHFTLIQAFCCEND------- ----------------------------------------------INILRVN-------------------STRRLGQI LAGGGK-------------------------------------------------------------------------- QSGGEPLDLHCVLVS--------SPHSTSWKDPALSKVSRFCRESRGMDQWVPI-------IYLPER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Oryzias_latipes_GADD45A_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEEVVGSSSTDKK--------- -------------------------------METVSQALEEL-----------------------LVAAQRQD------C LTVG--------VYESAKLMN----------------------------------------VDP---------------D SVVLCLLATDEEDADDIALQ---------------------------------------IHFTLLQAFCCDND------- ----------------------------------------------INILRVS-------------------GMRRLAQL LGEDTE------------------------------------------------------------------------NS N-GNEPRDLHCILVT--------NPPVQPLQCQALQDVSSFCAESRCRNLWVPC-------LELKDR------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Homo_sapiens_GADD45B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEELVACDNAAQK--------- -------------------------------MQTVTAAVEEL-----------------------LVAAQRQD------R LTVG--------VYESAKLMN----------------------------------------VDP---------------D SVVLCLLAIDEEEEDDIALQ---------------------------------------IHFTLIQSFCCDND------- ----------------------------------------------INIVRVS-------------------GMQRLAQL LGEPA-------------------------------------------------------------------------ET QGTTEARDLHCLLVT--------NPHTDAWKSHGLVEVASYCEESRGNNQWVPY-------ISLQER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Pan_troglodytes_GADD45B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEELVACDNAAQK--------- -------------------------------MQTVTAAVEEL-----------------------LVAAQRQD------R LTVG--------VYESAKLMN----------------------------------------VDP---------------D SVVLCLLAIDEEEEDDIALQ---------------------------------------IHFTLIQSFCCDND------- ----------------------------------------------INIVRVS-------------------GMQRLAQL LGEPA-------------------------------------------------------------------------ET QGTTEARDLHCLLVT--------NPHTDAWKSHGLVEVASYCEESRGNNQWVPY-------ISLQER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Macaca_mulatta_GADD45B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEELVACDNAAQK--------- -------------------------------MQTVTAAVEEL-----------------------LVAAQRQD------R LTVG--------VYESAKLMN----------------------------------------VDP---------------D SVVLCLLAIDEEEEDDIALQ---------------------------------------IHFTLIQSFCCDND------- ----------------------------------------------INIMRVS-------------------GMQRLAQL LGEPA-------------------------------------------------------------------------ET QGTTEARDLHCLLVT--------NPHTDAWKSHGLVEVASYCEESRGNNQWVPY-------ISLQER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Mus_musculus_GADD45B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEELVASDNAVQK--------- -------------------------------MQAVTAAVEQL-----------------------LVAAQRQD------R LTVG--------VYEAAKLMN----------------------------------------VDP---------------D SVVLCLLAIDEEEEDDIALQ---------------------------------------IHFTLIQSFCCDND------- ----------------------------------------------IDIVRVS-------------------GMQRLAQL LGEPA-------------------------------------------------------------------------ET LGTTEARDLHCLLVT--------NCHTDSWKSQGLVEVASYCEESRGNNQWVPY-------ISLEER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Canis_familiaris_GADD45B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEELVACDNAAQK--------- -------------------------------MQTVSAAVEEL-----------------------LVAAQRQD------R LTVG--------VYESAKLMN----------------------------------------VDP---------------D SVVLCLLAIDEEEEDDIALQ---------------------------------------IHFTLIQSFCCDND------- ----------------------------------------------IDIVRVS-------------------GMQRLAQL LGEPA-------------------------------------------------------------------------ET QGTAEARDLHCLLVT--------NPHTDAWKSHGLVEVASYCEESRGNNQWVPY-------ISLQER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Equus_caballus_GADD45B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEELVACDNAAQK--------- -------------------------------MQTVSAAVEEL-----------------------LVAAQRQD------R LTVG--------VYESAKLMN----------------------------------------VDP---------------D SVVLCLLAIDEEEEDDIALQ---------------------------------------IHFTLIQSFCCDND------- ----------------------------------------------INIVRVS-------------------GMQRLAQL LGEPA-------------------------------------------------------------------------ET QGTTEARDLHCLLVT--------NPHTDAWKSHGLVEVASYCEESRGNNQWVPY-------ISLQER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Pteropus_vampyrus_GADD45B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEELVACDNAAQK--------- -------------------------------MQTVSAAVEEL-----------------------LVAAQRQD------R LTVG--------VYESAKLMN----------------------------------------VDP---------------D SVVLCLLAIDEEEEGDIALQ---------------------------------------IHFTLIQSFCCDND------- ----------------------------------------------IDIVRVS-------------------GMQRLAQL LGEPD-------------------------------------------------------------------------EA QGTAEARDLHCLLVT--------NPHTDAWKSQGLVEVASYCEESRGNNQWVPY-------ISLQER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Monodelphis_domestica_GADD45B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEEVVACESAAQK--------- -------------------------------MQTVSNAVEEL-----------------------LVAAQRQD------R LTVG--------VYESAKLMN----------------------------------------VDP---------------D SVVLCLLAIDEDEEDDIALQ---------------------------------------IHFTLIQAFCCDND------- ----------------------------------------------IDIVRVS-------------------GMRRLAEL LGEPG-------------------------------------------------------------------------PN EESEETRDLHCLLVT--------NPHTDSWKSHGLVEVASYCEESRENNQWLPN-------ISLQER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Gallus_gallus_GADD45B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MDGQPQEGSDTEPRGRKAAPLLLP L---------------------------LLLLLTTTARSSRT-----------------------LRPAAPGG------R KEKG--------GLHRPHPHD----------------------------------------APPFH------PH--RDPD SVVLCVLATDEEDEGDIALQ---------------------------------------IHFTLIQAFCCDND------- ----------------------------------------------IHIVRVA-------------------GMRRLAAV LGEPA--------------------------------------------------------------------------- -PGAEPRDLHCLLVT--------MPHADAWQSHGLAEVANYCAESRDRNQWVPV-------VRLQER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Pelodiscus_sinensis_GADD45B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEELVACDNTAQK--------- -------------------------------MRIVSGAVEQL-----------------------LVAAPRRG------R LEF--------------SLDG----------------------------------------NDP---------------D SVVLCLLATDEEDADDIALQ---------------------------------------IHFTLIQAFCCDND------- ----------------------------------------------IHILRVS-------------------GMQRLATV LGENP--------------------------------------------------------------------------- QDNSEPRDLHCILVT--------NPHTDSWKSQGLEEVASYCEESRCNNQWVPC-------LSLLER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------- >Danio_rerio_GADD45B_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MTLEEVVGCNITDTK--------- -------------------------------MDTVSQALEEL-----------------------LVAAQRQD------C LTVG--------VYESAKLMN----------------------------------------VDP---------------D CVVLCILATDEEDLDDIALQ---------------------------------------IHFTLLQAFCCDND------- ----------------------------------------------INILRVS-------------------GLRRLAQV LDEPAT------------------------------------------------------------------------VE N--SEPRDFHCILVT--------NSQCQPLKCQALKDVGTYCEESRCKNQWIPY-------LSLQER------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------