>Homo_sapiens_MAN1A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MPVGGLLPLFSSPAGGVLGGGLGG--------GG-----------------GRKGSGPA ALRLTEKFVLLLVFSAFITLCFGAIFFLPDSSKLLS-----------------------------------GVLFHSSPA LQPAADHKPGPGARAEDAAEGRARRR--------EEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDIL LEKKK--VAQDQLRDKAPFRGLPPVDFVPP-------------------------IGVESREPADAAIREKRAKIKE--- ----------------------------MMKHAWNNYKGYAWGLNELKPISKGGHSSSLFG----NIKGA------TIVD ALDTLFIMEMKHEFEEAKSWVEENLDFNVN-AEISVFEVNIRFVGGLLSAYYLSG--------------EEIFRKKA-VE LGVKLLPAFH-TPSGIPWALLNMKSGIGRNWPWASGG-SSILAEFGTLHLEFMHLSHLSGNPIFAEK--VMNIRTVLNKL EKPQG-----------------------LYPNYLNPSSG-QWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDL-EAKKMYF DAVQAIETHLIRKSS---------SGLTYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMFALG AD-------------AAPEG-MAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIA------TRQNEKYYILR PEVMETYMYMWRLTHDPKYRKWAWEAVE---------ALENHCRVNGG-YSGLRDVYLLHESYDDV----------QQSF FLAETLK----YLYLIFSDDD--LLPLE-HWIFNSEAHLLP--------------------------------------- -------------------------------------ILPKDKKEVEIREE----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Pan_troglodytes_MAN1A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MPVGGLLPLFSSPAGGGLGGGLGG--------GG-----------------GRKGSGPA ALRLTEKFVLLLVFSAFITLCFGAIFFLPDSSKLLS-----------------------------------GVLFHSSPA LQPDADHKPGPGARAEDAAEGRARRR--------EEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDIL LEKKK--VARDQLRDKAPFRGLPPVDFVPP-------------------------IGVESREPADAAIREKRAKIKE--- ----------------------------MMKHAWNNYKGYAWGLNELKPISKGGHSSSLFG----NIKGA------TIVD ALDTLFIMEMKHEFEEAKSWVEENLDFNVN-AEISVFEVNIRFVGGLLSAYYLSG--------------EEIFRKKA-VE LGVKLLPAFH-TPSGIPWALLNMKSGIGRNWPWASGG-SSILAEFGTLHLEFMHLSHLSGNPIFAEK--VMNIRTVLNKL EKPQG-----------------------LYPNYLNPSSG-QWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDL-EAKKMYF DAVQAIETHLIRKSS---------SGLTYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMFALG AD-------------AAPEG-MAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIA------TRQNEKYYILR PEVMETYMYMWRLTHDPKYRKWAWEAVE---------ALEKHCRVNGG-YSGLRDVYLLHESYDDV----------QQSF FLAETLK----YLYLIFSDDD--LLPLE-HWIFNSEAHLLP--------------------------------------- -------------------------------------ILPKDKKEVEIREE----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Macaca_mulatta_MAN1A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MPVGGLLPLFSSPAGGGLGGGLGG--------GG-----------------GRKVSGPA ALRLTEKFVLLLVFSAFITLCFGAIFFLPDSSKLLS-----------------------------------GVLFHSSPA LQPAADHKPGPGARAEDAAEGRARRR--------EEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDIL LEKKK--VAQDQLRDKAPFRGLPPVDFVPP-------------------------IGVESREPADAAIREKRAKIKE--- ----------------------------MQKENWQSYSGWHLALNQESQYSSSNPASNLYK----DISTAP-----AIID VNKDYFTMEQVTSYMDGRSQREKELRFPLYNAEISVFEVNIRFVGGLLSAYYLSG--------------EEIFRKKA-VE LGVKLLPAFH-TPSGIPWALLNMKSGIGRNWPWASGG-SSILAEFGTLHLEFMHLSHLSGNPIFAEK--VMNIRTVLNKL EKPQG-----------------------LYPNYLNPSSG-QWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDL-EAKKMYF DAVQAIETHLIRKSS---------SGLTYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMFALG AD-------------GAPEA-MAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIA------TRQNEKYYILR PEVMETYMYMWRLTHDPKYRKWAWEAVE---------ALENHCRVNGG-YSGLRDVYLLHESYDDV----------QQSF FLAETLK----YLYLIFSDDD--LLPLE-HWIFNSEAHLLP--------------------------------------- -------------------------------------ILRKEKKEVEIREE----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Mus_musculus_MAN1A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MPVGGLLPLFSSPGGGGLGSGLGGG------LGG-----------------GRKGSGPA AFRLTEKFVLLLVFSAFITLCFGAIFFLPDSSKLLS-----------------------------------GVLFHSNPA LQPPAEHKPGLGARAEDAAEGRVRHR--------EEGAPGDPGAGLEDNLARIRENHERALREAKETLQKLPEEIQRDIL LEKEK--VAQDQLRDKDLFRGLPKVDFLPP-------------------------VGVENREPADATIREKRAKIKE--- ----------------------------MMTHAWNNYKRYAWGLNELKPISKEGHSSSLFG----NIKGA------TIVD ALDTLFIMGMKTEFQEAKSWIKKYLDFNVN-AEVSVFEVNIRFVGGLLSAYYLSG--------------EEIFRKKA-VE LGVKLLPAFH-TPSGIPWALLNMKSGIGRNWPWASGG-SSILAEFGTLHLEFMHLSHLSGDPVFAEK--VMKIRTVLNKL DKPEG-----------------------LYPNYLNPSSG-QWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDL-EAKKMYF DAVQAIETHLIRKSS---------GGLTYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMFALG AD-------------GAPEA-RAQHYLELGAEIARTCHESYNRTYVKLGPEAFRFDGGVEAIA------TRQNEKYYILR PEVIETYMYMWRLTHDPKYRTWAWEAVE---------ALESHCRVNGG-YSGLRDVYIARESYDDV----------QQSF FLAETLK----YLYLIFSDDD--LLPLE-HWIFNTEAHPFP--------------------------------------- -------------------------------------ILREQKKEIDGKEK----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Rattus_norvegicus_MAN1A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MPVGGLLPLFSSPGGGGLGGGLGGG------LGG-----------------GRKGSGPA AFRLTEKFVLLLVFSAFITLCFGAIFFLPDSSKLLS-----------------------------------GVLFHSNPA LQPPAEHKPGLGARAEDAAEGRVRHR--------EEGVPGDPGAGLEDNLARIRENHERALREAKETLQKLPEEIQRDIL LEKEK--VAQDQLRDKDLFGGLPKVDFLPP-------------------------IGVENREPADATIREKRSKIKE--- ----------------------------MMAHAWNNYKRYAWGLNELKPISKEGHSSSLFG----NIKGA------TIVD ALDTLFIMGMKTEFQEAKSWIKKYLDFNVN-AEVSVFEVNIRFVGGLLSAYYLSG--------------EEIFRKKA-VE LGVKLLPAFH-SPSGIPWALLNMKSGIGRNWPWASGG-SSILAEFGTLHLEFMHLAHLSGNPVFAEK--VMNIRTVLNKL DKPEG-----------------------LYPNYLNPSSG-QWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDL-EAKKMYF DAVQAIETHLIRKSS---------GGLTYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMFALG AD-------------GAPEA-RAQHYLELGAEIARTCHESYNRTYVKLGPEAFRFDGGVEAIA------TRQNEKYYILR PEVIETYMYMWRLTHDPKYRTWAWEAVE---------ALESHCRVNGG-YSGLRDVYIAHESYDDV----------QQSF FLAETLK----YLYLIFSDDD--LLPLE-HWIFNTEAHPFP--------------------------------------- -------------------------------------ILRDQKKEVDVQEK----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Oryctolagus_cuniculus_MAN1A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MPVGGLLPLFGSPAGGGLGGGLGGGLG----GGG-----------------GRKGSGPA AFRLTEKFVLLLVFSAFITLCFGAIFFLPDSSKLLS-----------------------------------GVLFHSSPA LQPAADHKPGPGARAEDAAEGRARRR--------EEGAPEDPAADREDPLARIRENHERALREAKETLQKLPEEIQRDIL REKEK--VAQDQLRDRAPFRRLPPVDFVPP-------------------------IGLENREPADAAVREKRAKIKE--- ----------------------------MMEHAWNSYKRYAWGLNELKPITKEGHSSSLFG----TIKGA------TIVD ALDTLFIMGMESEFQEAKSWIAENLDFNVN-AEISVFEVNIRFVGGLLSAYYLSG--------------EEIFRKKA-VE LGIKLLPAFH-TPSGIPWALLNIKSGIGRNWPWASGG-SSILAEFGTLHLEFMHLSHLSGNPIFAEK--VMNIRKVLNKL EKPEG-----------------------LYPNYLNPSSG-QWGQHHVSIGGLGDSFYEYLLKAWLMSEKTDL-EAKKMYF DAVQAIETHLIRKSS---------GGLTYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMFALG AD-------------GAPEG-RAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIA------TRQNEKYYILR PEVVETYMYMWRLTHDPKYRKWAWEAVE---------ALESHCRVNGG-YSGLRDVYFTHEKYDNV----------QQSF FLAETLK----YLYLIFSDDD--LLPLE-HWIFNTEAHLLP--------------------------------------- -------------------------------------ILPTDQKEVEVKVK----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Ornithorhynchus_anatinus_MAN1A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------QMMKHSWDNYKRYAWGLNELKPISKQGHSSNLFG----NIQGA------TIVD ALDTLYIMEMKDEFKEAKEWVEKNLEFNVN-AEISVFEVNIRFVGGLLSAYYLSG--------------EEIFRRKA-VE LGEKLLPAFN-TPTGIPWALLNMKSGIGRNWPWASGG-SSILAEFGTLHLEFIHLSHLSGNPVFAEK--VMNIRKVLNQL DKPEG-----------------------LYPNYLNPSSG-QWGQHHVSIGGLGDSFYEYLLKAWLMSDKTDE-EAKKMYF EAVQAIETHLIRKSS---------SGLTYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMFALG AD-------------SAPND-KTGRHIELGAEIARTCHESYDRTNVKLGPEAFRFDGGVEAIA------TRQNEKYYILR PEVLETYMYMWRLTHDPKYRKWGWEAVETQ-------ALEKHCRIDGG-YSGLRDVYSNHLSHDDV----------QQSF FLAETLK----YLYLLFSDDD--LLPLE-HWIFNTEAHLLP--------------------------------------- -------------------------------------ILRKDAEKEDKH------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Gallus_gallus_MAN1A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------HQFKICMLKGKKEIILE--- ----------------------------MMKYAWDNYKRYAWGLNELKPISKQGHSSNLFG----NIQGA------TIVD ALDTLFIMEMKEEFKEAKEWVEKNLDFNVN-AEISVFEVNIRFVGGLLSAYYLSG--------------EEIFRKKA-VE LGEKLLPAFN-TPTGIPWALLNIKSGIGRNWPWASGG-SSILAEFGTLHLEFVHLSHLSGNPVFAEK--VMNIRKVLSRL DKPEG-----------------------LYPNYLNPSSG-QWGQHHVSIGGLGDSFYEYLLKAWLMSDKTDE-EGKKMYY DAVQAIETHLIRKSS---------GGLTYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMFALG AD-------------GAPSD-KTGHHIELGAEIARTCHESYDRTSMKLGPEAFRFDGGVEAIA------TRQNEKYYILR PEVIETYMYMWRLTHDPKYRQWAWEAVE---------ALEKHCRVDGG-YSGIRDVYSNHESHDDV----------QQSF FLSETLK----YLYLLFSDDD--LLPFE-HWVFNTEAHPFP--------------------------------------- -------------------------------------ILRKEDGSKEEKEK----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Anolis_carolinensis_MAN1A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MPAVSLLPLFGSPSGPGASLGASLGGG---APGG-----------------ARKAPGPS AFRLTEKFVLLLVFSAFITLCFGAIFFLPDSPKLLS-----------------------------------GVLFHSRPP PQQQHPPP-------------LPPLP--------PAGGGLSSSSDANANLAKIREDHERALREAKETLQKQPDEIRSDIH RDKEKFLLLQDRVGRSGAKDGLPELPFRKP-------------------------VGAVGGEPPDPAARQKRDKIKE--- ----------------------------MMKHAWDNYKHYAWGLNELKPISKQGHSSNLFG----NIQGA------TIVD ALDTLYIMEMKDEFKEAKEWVEKNLDFNVN-AEVSVFEVNIRFVGGLLSAYYLSG--------------EEIFRKKA-VE LGEKLLPAFN-TPTGIPWALLNIKSGIGRNWPWASGG-SSILAEFGTLHLEFIHLSYLSGNPVFAEK--VMNIRKVLNRL DKPEG-----------------------LYPNYLNPNSG-QWGQHHVSIGGLGDSFYEYLLKAWLMSDKTDE-EGRQMYY DAVQSIDTHLIRKSS---------TGLMYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMFVLG AD-------------GAPAD-KTGRHVELGAEIARTCHESYDRTSMKLGPEAFRFDGGVEAIA------TRQNEKYYILR PEVIETYMYMWRFTHDPKYREWGWEAVE---------ALEKYCRVDGG-YSGVKDVYSNHPSHDDV----------QQSF FLSETLK----YLYLLFSEDD--LLPFE-HWVFNTEAHPFP--------------------------------------- -------------------------------------ILTTE-ERQKVKGK----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Pelodiscus_sinensis_MAN1A1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MMKHSWDNYKRYSWGLNELKPISKQGHSSNLFG----NIQGA------TIVD ALDTLYIMEMKDEFKEAKEWVEKNLDFNVN-AEISVFEVNIRFVGGLLSAYYLSG--------------EEIFRKKA-VE LGEKLLPAFN-TPTGIPWALLNIKSGIGRNWPWASGG-SSILAEFGTLHLEFIHLSHLSGNPVFAEK--VMNIRKVLNRL DKPEG-----------------------LYPNYLNPSSG-QWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDE-EGKKMYY DAVQSIETHLIRKSS---------GGLTYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMFALG AD-------------GAPND-KTGHHIELGAEIARTCHESYDRTSMKLGPEAFRFDGGVEAIA------TRQNEKYYILR PEVIETYMYMWRFTHDPKYRQWGWEAVE---------ALEQHCRVDGG-YSGIRDVYSNHQSHDDV----------QQSF FLSETLK----YLYLLFSEDD--LLPFE-HWIFNTEAHPLP--------------------------------------- -------------------------------------VLHRDDEKKEEKHK----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Danio_rerio_MAN1A1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MPVASLLPFTATPNR--------------------------------------KSASPT SFRLTEKFILLLVFSAFITLCFGAIFFLPDSSKLLS-----------------------------------GVFFRSS-- -----------------SVEAETRAG--------TVSDTSTGTGKDEKILAKIRKDHEKALLEAKDTLQKRPDEIKEDIN NDKIK--FEQNR---PVKDDSLPFVPYVRP-------------------------PGATGHEPADPDIKAKRAKIKE--- ----------------------------MMQFAWDNYKHYAWGSNELRPVSKQGHSSNLFG----SLKGA------TIVD ALDTLYIMEMYDEFEAATEWVEKNLDFNMN-AEISVFEVNIRFVGGLLSAYYLSG--------------KEVFRKKA-VE LGEKLLPAFK-TPTGVPWALLNLKSGVGRNWPWASGG-SSILAEYGTLHLEFMHLSALSGRPVFAEK--VMNIRKVLTRL DKPQG-----------------------LYPNYLNPNSG-QWGQHHVSVGGLGDSFYEYLLKAWLMSDKIDE-EGKKLYY DALQAIEKNLIRKSS---------GGLTYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMIALG AD-------------GAPDE-KTGHQMELAAEIARTCHESYVRTNLKLGPEAFRFDGGVEAIA------TRQNEKYFILR PEVIETYMYMWRFTHDPKYRQWGWEAVQ---------ALEKHCRVEGG-YSGVRDVYSNNPNHDDV----------QQSF YLAETLK----YLYLLFSDDD--HLPFD-HWVFNTEAHPLP--------------------------------------- -------------------------------------VIKKESPELPNHLK----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Gasterosteus_aculeatus_MAN1A1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------TPPPGFPPLTGQKCEPGG---------------I-----------------GVSSLRPT SFRLTEKFILLLVFSAFITLCFGAIFFLPDSSKLLS-----------------------------------GVFFHSP-- -----------------AVETNTRPG--------SDSSDPASA-NDERVLAKIRKDHEKALLEAKDTLQKRPDEIKQDIL NEKEK--VAKEN--TGQGGNDLPFVEYHRP-------------------------PGATGHEPQDPETKEKRAKIKE--- ----------------------------MMKHAWGSYRRYAWGSNELRPVSKQGHSSNLFG---GSIKGA------TIVD ALDTLYIMEMFEEFDAATDWVEKNLDFNMN-AEVSVFEVNIRFVGGLLSAYYLSG--------------KEVYRRKA-VE LGEKLLPAFK-TPTGIPWALLNLKSGIGRNWPWASGG-SSILAEYGTLHLEFMHLSKLSGNPDFEQK--VMNIRKVLNRL DKPQG-----------------------LYPNYLNPNSG-QWGQHHVSVGGLGDSFYEYLLKAWLMSDKADE-EGKKMYY DALQAIETNLMRKST---------SGLTYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMIALG AD-------------GAPGD-KTGHQMEQAAEIARTCHESYARTALKLGPEAFRFDGGVEAIA------TRQNEKYFILR PEVIETYMYMWRFTHDPKYREWGWEAVQ---------ALEQHCRVEGG-YSGVRDVYASAPNHDDV----------QQSF YLAETLK----YLYLLFSDDD--HLPFD-HWVFNTEAHPLP--------------------------------------- -------------------------------------VLKKDKTDIPNEVE----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Oryzias_latipes_MAN1A1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MPVATLLPFTSTPNR--------------------------------------KSVSAT SFRLTEKFILLLVFSAFITLCFGAIFFLPDSSKLLS-----------------------------------GVFFRSS-- -----------------AVETNTRTG--------PDGSEPGSAGNDGRVLDKIRKDHDKALLEAKDILQKRPDDIKNDIL SDKNK--VPNSSDQNGKKANDLPSVEFHRP-------------------------PGAIGSEPRDPETRERRAKVKE--- ----------------------------MMKHAWDSYRRYAWGSNELRPVSKQGHSSNLFG----SIKGA------TIVD ALDTLFIMEMSEEFNAATEWVEKNLDFNVN-AEVSVFEVNIRFVGGLLSAYYLSG--------------KEVFRQKA-VE LGEKLLPAFR-TSTGIPWALLNLKSGVGRNWPWASGG-SSILAEYGTLHLEFMHLSKLSGNQEFAQK--VMNIRKVLNRL DKPQG-----------------------LYPNYLNPNSG-QWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDE-EGKKMYY DSLQAIETSLIRKSS---------GGLTYIAEWKGG-LLE-HKMG----------------------HLTCFAGGMIALG AD-------------GAPGD-KTGHQMELAAEIARTCHESYARTALKLGPEAFRFDGGVEAIA------TRQNEKYFILR PEVIETYMYMWRFTHDPKYREWGWEAVQ---------ALERHCKVEGG-YSGVRDVYSSNPSLDDV----------QQSF FLAETLK----YLYLLFSEDD--QLPFD-HWVFNTEAHPLP--------------------------------------- -------------------------------------VIRKEQTDRPNEVE----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Homo_sapiens_MAN1A2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MTTPALLPLSGR-------------RIPPLNLGP-----------------PSFPHHRA TLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKR-----------------------------------FDLGLEDVL IPHVDAGK-GAKNPGVFLIHGP---------------DEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQ TEKNK--VVQEMKIKE--NKPLPP--VPIPN-----------------------LVGIRGGDPEDNDIREKREKIKE--- ----------------------------MMKHAWDNYRTYGWGHNELRPIARKGHSPNIF--GS-SQMGA------TIVD ALDTLYIMGLHDEFLDGQRWIEDNLDFSVN-SEVSVFEVNIRFIGGLLAAYYLSG--------------EEIFKIKA-VQ LAEKLLPAFN-TPTGIPWAMVNLKSGVGRNWGWASAG-SSILAEFGTLHMEFIHLSYLTGDLTYYKK--VMHIRKLLQKM DRPNG-----------------------LYPNYLNPRTG-RWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDH-EARKMYD DAIEAIEKHLIKKSR---------GGLTFIGEWKNG-HLE-KKMG----------------------HLACFAGGMFALG AD-------------GSRAD-KAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVA------VRQAEKYYILR PEVIETYWYLWRFTHDPRYRQWGWEAA--L-------AIEKYCRVNGG-FSGVKDVYSSTPTHDDV----------QQSF FLAETLK----YLYLLFSGDD--LLPLD-HWVFNTEAHPLP--------------------------------------- -------------------------------------VLHLANTTLSGNPAVR--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Pan_troglodytes_MAN1A2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MTTPALLPLSGR-------------RIPPLNLGP-----------------PSFPHHRA TLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKR-----------------------------------FDLGLEDVL IPHVDAGK-GAKNPGVFLIHGP---------------DEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQ TEKNK--VVQEMKIKE--NKPLPP--VPIPK-----------------------LVGVSGGDPEDNDIREKREKIKE--- ----------------------------MMKHAWDNYRTYGWGHNELRPIARKGHSPNIF--GS-SQMGA------TIVD ALDTLYIMGLHDEFLDGQRWIEDNLDFSVN-SEVSVFEVNIRFIGGLLAAYYLSG--------------EEIFKTKA-VQ LAEKLLPAFN-TPTGIPWAMVNLKSGVGRNWGWASAG-SSILAEFGTLHMEFIHLSYLTGDLTYYKK--VMHIRKLLQKM DRPNG-----------------------LYPNYLNPRTG-RWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDH-EARKMYD DAIEAIEKHLIKKSR---------GGLTFIGEWKNG-HLE-KKMG----------------------HLACFAGGMFALG AD-------------GSRAD-KAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVA------VRQAEKYYILR PEVIETYWYLWRFTHDPRYRQWGWEAA--L-------AIEKYCRVSGG-FSGVKDVYSSTPTHDDV----------QQSF FLAETLK----YLYLLFSGDD--LLPLD-HWVFNTEAHPLP--------------------------------------- -------------------------------------VLHLANTTLSGNPAVR--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Macaca_mulatta_MAN1A2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MTTPALLPLSGR-------------RIPPLNLGP-----------------PSFPHHRA TLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKR-----------------------------------FDLGLEDVL IPHVDAGK-GAKNPGVFLIHGP---------------DEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQ TEKNK--VVQEMKIKE--NKPLPP--VPIPN-----------------------LVGISGGDPEDNDIREKREKIKE--- ----------------------------MMKHAWDNYRTYGWGHNELRPIARKGHSPNIF--GN-SQMGA------TIVD ALDTLYIMGLHAEFLDGQRWIEDNLDFSVN-SEVSVFEVNIRFIGGLLAAYYLSG--------------EEIFKIKA-VQ LAEKLLPAFN-TPTGIPWAMVNLKSGVGRNWGWASAG-SSILAEFGTLHMEFIHLSYLTGDLIYYKK--VMHIRKLLQKM DRPNG-----------------------LYPNYLNPRTG-RWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDH-EARKMYD DAIEAIEKHLIKKSR---------GGLVFIGEWKNG-HLE-KKMG----------------------HLACFAGGMFALG AD-------------GSRTD-KAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVA------VRQAEKYYILR PEVIETYWYLWRFTHDPRYRQWGWEAA--L-------AIEKYCRVTGG-FSGVKDVYSSTPTHDDV----------QQSF FLAETLK----YLYLLFSGDD--LLPLD-HWVFNTEAHPLP--------------------------------------- -------------------------------------VLHLANTTLSGNPAVR--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Mus_musculus_MAN1A2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MTTPALLPLSGR-------------RIPPLNLGP-----------------PSFPHHRA TLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKR-----------------------------------FDLGLEDVL IPHVDAGK-GAKNPGVFLIHGP---------------DEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQ TEKNK--VAQAMKTKE--TRVLPP--VPVPQ-----------------------RVGVSGGDPEDMEIKKKRDKIKE--- ----------------------------MMKHAWDNYRTYGWGHNELRPIARKGHSTNIF--GS-SQMGA------TIVD ALDTLYIMGLHDEFMDGQRWIEENLDFSVN-SEVSVFEVNIRFIGGLLAAYYLSG--------------EEIFKTKA-VQ LAEKLLPAFN-TPTGIPWAMVNLKSGVGRNWGWASAG-SSILAEFGTLHMEFVHLSYLTGDLTYYNK--VMHIRKLLQKM ERPNG-----------------------LYPNYLNPRTG-RWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDH-EARRMYD DAVEAIEKHLIKKSR---------GGLVFIGEWKNG-HLE-RKMG----------------------HLACFAGGMFALG AD-------------GSRKD-KAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVA------VRQAEKYYILR PEVIETYWYLWRFTHDPRYRQWGWEAA--L-------AIEKSCRVSGG-FSGVKDVYAPTPVHDDV----------QQSF FLAETLK----YLYLLFSGDD--LLPLD-HWVFNTEAHPLP--------------------------------------- -------------------------------------VLRLANSTLSGNPAVR--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Rattus_norvegicus_MAN1A2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MTTPALLPLSGR-------------RIPPLNLGP-----------------PSFPHHRA TLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKR-----------------------------------FDLGLEDVL IPHVDAGK-GAKDPGVFLIHGP---------------DEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQ TEKNK--VAQAMKTKE--TRVLPP--VPVPQ-----------------------RVGVSGGDPEDAEIRKKRDKIKE--- ----------------------------VISRGWDVADSKGWNHNKLKIIARKGHSTNIF--GS-SQMGA------TIVD ALDTLYIMGLHDEFMDGQRWIEDNLDFSVN-SEVSVFEVNIRFIGGLLAAYYLSG--------------EEIFKTKA-VQ LAEKLLPAFN-TPTGIPWAMVNLKSGVGRNWGWASAG-SSILAEFGTLHMEFVHLSYLTGDLTYYNK--VMHIRKLLQKM ERPNG-----------------------LYPNYLNPRTG-RWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDH-EARRMYD DAVEAIEKHLIKKSR---------GGLVFIGEWKNG-HLE-RKMG----------------------HLACFAGGMFALG AD-------------GSRKD-KAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVA------VRQAEKYYILR PEVIETYWYLWRFTHDPRYRQWGWEAA--L-------AIEKSCRVSGG-FSGVKDVYSPTPAHDDV----------QQSF FLAETLK----YLYLLFSGDD--LLPLD-HWVFNTEAHPLP--------------------------------------- -------------------------------------VLRLANTTLSGNPAVR--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Felis_catus_MAN1A2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MTTPALLPLSGR-------------RIPPLNLGP-----------------PSFPHHRA TLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKR-----------------------------------FDLGLEDVL IPHVDASK-GAKNPGVFLIHGP---------------DEHRHREEEERLRNKIRADHEKALEEAKEKLKKSREEIRAEIQ TEKNK--VVQEMKTKE--KKPLPP--VPIPN-----------------------LIGIDGGDPEDNDIRKKREKIKE--- ----------------------------MMKHAWDNYRIYGWGHNELRPIARKGHSTNIF--GS-SQMGA------TIVD ALDTLYIMGLHDEFRDGQKWIEHNLDFSVN-SEVSVFEVNIRFIGGLLAAYYLSG--------------EEIFKIKA-VQ LAEKLLPAFN-TPTGIPWAMVNLKSGVGRNWGWASAG-SSILAEFGTLHMEFVHLSYLTGDPVYYKK--VMHIRKLLQKM DRPNG-----------------------LYPNYLNPRTG-RWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDH-EARKMYD DAIEAIEKHLIKKSR---------GGLTFIGEWKNG-HLE-KKMG----------------------HLACFAGGMFALG AD-------------GSRMD-KAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVA------VRQAEKYYILR PEVIETYWYLWRFTHDPRYRQWGWEAA--L-------AIEKYCRVSGG-FSGVKDVYSSTPTHDDV----------QQSF FLAETLK----YLYLLFSSDD--LLPLD-HWVFNTEAHPLP--------------------------------------- -------------------------------------VLHLANTTLSGNPAVR--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Gallus_gallus_MAN1A2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MSAPALLPLAGR-------------RLPALNLGA-----------------SSFPHHRA TLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKR-----------------------------------FDLGLEDVL IPHVDTSK-GGKHLGSFLIHGQG-------------HDEHRHREEEERLRNKIRADHEKALEEAKEKLKKSRDEIQAEIQ TEKNK--VVQELKKKD--SKPLPP--VPLPN-----------------------LVGINSGEPADPDIREKRNKIKE--- ----------------------------MMKHAWDNYRQYGWGHNELKPIARKGHSTNIF--GN-SQMGA------TIVD ALDTLYIMGLRDEFREGQEWIDKNLDFSVN-SEVSVFEVNIRFIGGLLAAYYLSG--------------QEVFKIKA-VQ LAGKLLPAFN-TPTGIPWAMVNLKSGVGRNWGWASAG-SSILAEFGTLHMEFVHLSYLTGDPVYYNK--VMHIRKLLQKM DRPNG-----------------------LYPNYLNPRTG-RWGQHHTSVGGLGDSFYEYLLKAWLMSDKTDT-EARKMYD DAIEAIEKHLIRKSN---------GGLTFIGEWKNG-HLE-RKMG----------------------HLTCFAGGMFALG AD-------------GSRDD-KAGHYLQLGAEIAHTCHESYDRTTLKLGPEAFKFDGGVEAVA------VRQNEKYYILR PEVIETYWYMWRFTHDPKYRQWGWEAT--Q-------AIDKYCRVSGG-FSGVKDVYSSSPTYDDV----------QQSF FLAETLK----YLYLLFSNDD--LLPLD-NWVFNTEAHPLP--------------------------------------- -------------------------------------VLHLANTTLSGNPAYR--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Anolis_carolinensis_MAN1A2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MTTPALLPLSGR-------------RIPPRSLGPS----------------SSFPHHRA TLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKR-----------------------------------FDLGLEDVL IPHVEAGE-GGKQAGGYLIHGQG-------------RDQHRHREEEERLRNKIRADHEKALEEAKEKLQKSQVEIQAEIQ TEKSK--IAKSLKNKS--NKPLPP--VPVPN-----------------------LIGINDGDPVDPNIREKRDKIKE--- ----------------------------MMKHAWDNYRRYGWGHNELKPIGRKGHSTNIF--GN-SQLGA------TIVD ALDTLYIMGLHDEFREGQEWIDNHLDFSVN-SEVSVFEVNIRFIGGLLAAYYLSG--------------QEVFKIKA-VQ LAGKLLPAFN-TPTGIPWAMVNLKSGVGRNWGWASAG-SSILSEFGTLHMEFVHLSYLTGNPVYYEK--VMHIRKLLQKM DRPNG-----------------------LYPNYLNPRTG-RWGQHHTSMGGLGDSFYEYLLKAWLMSDKMDV-EARKMYD DAMEAIEKHLIRKSN---------GGLTFIGEWKNG-HLE-RKMG----------------------HLTCFAGGMFALG AD-------------GSRDD-KAGHYLQLGAEIAHTCHESYDRTTLKLGPEAFKFDGGGEAVP------VR-------LE PEASVNNWSCC-FTHAAQYRLWGWGSSTER-------AIDKYCRVSGG-FSGVKDVYSSAPTFDDV----------QQSF FLAETLK----YLYLLFSSDD--LLPLD-HWVFNTEAHPLP--------------------------------------- -------------------------------------VLHLANTTLSGNHVYR--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Xenopus_tropicalis_MAN1A2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MTTPALLPLTGR-------------RIPALNLGP-----------------SSFPHHRA TLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKR-----------------------------------FDLGLEDVL IPHIESNK-GAKNSGSVLIHGQ-------------GHDEHRHREEEEQLRNKIRADHERALEEAKEKLKKSRDEIRAEIQ TEKSK--LAEELKKKDNPPPPLAP--VPN-------------------------LPEIKNGDPGDPDIREKRDKIKE--- ----------------------------MMKHAWDNYKQYGWGHNELKPIARKGHSTNIF--GN-SQMGA------TIVD ALDSLYIMGLLDEFREGQEWVQNNLDFSVN-AEVSVFEVNIRFIGGLLAAFYLSG--------------QEVFKNKA-VL LAEKLLPAFN-TPTGIPWAMVNLKTGVGRNWGWASAG-SSILAEFGTLHLEFVHLSYLTGNPVYYNK--VMHIRKLLQKM DRPNG-----------------------LFPNYLNPRTG-RWGQHHTSVGGLGDSFYEYLLKAWLVSDRSDI-EARHMYD SAIEAIERHLVRKSS---------GGLTFIGEWKNG-HLE-RKMG----------------------HLTCFAGGMLALG AD-------------GSPGE-KAGHYLQLGAEIAHTCHESYDRTVLKLGPEAFKFDGGAEAVA------VRQNEKYYILR PEVIETYWYMWRFTHDPKYRRWGWEAA--Q-------AIDKYCRVSGG-FSGIKDVYSSSPTYDDV----------QQSF FLAETLK----YLYLLFSSDD--LLPLD-NWVFNTEAHPLP--------------------------------------- -------------------------------------VIHLVNSTLPGNPVAR--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Danio_rerio_MAN1A2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MTTPALLPLSGR-------------RIPTLSPGA-----------------SSFPHHRA TLRLSEKFILLLILSAFITLCFGAFFFLPDNSKHKR-----------------------------------FDFGLEDVL IPHIETEKESRHGS-RQVIHGV------------GAHDEHRHREEEESLRDKIRADHERALQEAKEKLRKSKEELKAEIQ TAKAK--VSEDLKKKD-GPKPLPP--VPMPK-----------------------LVGVNDGDPGDPDTKEKRDKIRE--- ----------------------------MMKHAWDSYRQYGWGHNELKPLAKKGHSTNIF--GN-SQMGA------TIVD ALDTLYIMGLHDEFKDGQEWIEQNLDFSVN-AEVSVFEVNIRFIGGLLAAYYLSG--------------QEVFKLKA-VQ LAEKLLPAFN-TPTGIPWAMVNLKSGVGRNWGWASGG-SSILAEFGTLHMEFVHLTYLTGNPAYYQK--VMHIRKLLAKM DRPNG-----------------------LYPNYLNPRTG-RWGQHHTSVGGLGDSFYEYLLKAWLMSDKTDA-EARKTYD DAIEAIERHLIRKSN---------GGLTFIGEWKNG-HLE-RKMG----------------------HLTCFAGGMFALG AD-------------GSPDD-KAGHYLQLGAEIAHTCHESYDRTVLKLGPEAFKFDSGLEAVA------VRQNEKYYILR PEVIETYWYMWRFTHDPKYRQWGWEAA--Q-------AIDKHCRVSGG-FSGVKDVYSSNPTYDDV----------QQSF FLAETLK----YLYLLFSSDE--LLPLE-NWVFNTEAHPLP--------------------------------------- -------------------------------------VLHLGNITLPGSESQR--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Takifugu_rubripes_MAN1A2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------RTLDHLLPLREHAPGSFGFKTQQAGKWAAGGGGG-----------------GRCFGGRA TLRLSEKFILLLILSAFVTLCFGAFFFLPDNSKHKR-----------------------------------FDLGLEDVL IPHIDPPKEGKHSSGQRVETASSQAPGLFVAAPGGGPRGQPAREEEESLRDKIRADHERALQEAKEKLRKSREELQAEIQ TEKNK--VVEDLKKKDSGPKPLPP--VPMPK-----------------------VVGVSDGEPLEPDVKEKRDKIRE--- ----------------------------MMKHAWDSYRQYGWGHNELKPLAKKGHSTNIF--GN-SQLGA------TIVD ALDTLYIMGLHEEFRDGQEWIEQNLDFGVN-AEVSVFEVNIRFIGGLLAAYYLSG--------------QEVFKMKA-VQ LAEKLLPAFN-TPTGIPWAIVNLKSGVGRNWGWASAG-SSILAEFGTLHMEFVHLTYLTGNPAYYQK--VMHIRKLLAKM DRPNG-----------------------LYPNYLNPRTG-RWGQHHTSVGGLGDSFYEYLLKAWLMSDKTDA-EARKTYD DAIEAIERHLIRKSN---------GGLTFIGEWKNG-HLE-RKMG----------------------HLACFAGGMFALG AD-------------GSPDD-KAGHYLQLGAEIAHTCHESYDRTVLKLGPEAFKFDSGLEAVA------VRQNEKYYILR PEVIETYWYMWRFTHDPKYRQWGWEAA--Q-------AIDKYCRVSGG-FSGVKDVYSSNPTYDDV----------QQSF FLAETLK----YLYLLFSSDD--LMPFE-SWVFNTEAHPLP--------------------------------------- -------------------------------------VLHLGNITLPGSEP----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Tetraodon_nigroviridis_MAN1A2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MTTPALLPLSGR-------------RIPTLSPGA-----------------SSFPHHRA TLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKR-----------------------------------FDLGLEDVL IPHIDSPKEGKHASGQVVIHGQ------------GAHDEHRHREEEESLRDKIRADHERALQEAKEKLRKSREELQAEIQ TEKNK--VAEDLKKKDSGPKPLPP--VPMPR-----------------------VVGVSDGEPPEPDVKEKRDKIRE--- ----------------------------MMKHAWDSYRQYGWGHNELKPLAKKGHSTNIF--GN-SQLGA------TIVD ALDTLYIMGLHEEFKDGQEWIEQNLDFGVN-AEVSVFEVNIRFIGGLLAAYYLSG--------------QEVFKMKA-VQ LAEKLLPAFN-TPTGIPWAIVNLKSGVGRNWGWASAG-SSILAEFGTLHMEFVHLTYLTGNPAYYQK--VMHIRKLLAKM DRPNG-----------------------LYPNYLNPRTG-RWGQHHTSVGGLGDSFYEYLLKAWLMSDKTDT-EARKTYD EAMEAIERHLIRKSN---------GGLTFIGEWKNG-HLE-RKMG----------------------HLACFAGGMFALG AD-------------GSPDD-KAGHYLQLGAEIAHTCHESYDRTVLKLGPEAFKFDSGLEAVA------VRQNEKYYILR PEVIETYWYMWRFTHDPKYRQWGWEAA--Q-------AIDKYCRVSGG-FSGVKDVYSSSPTYDDV----------QQSF FLAETLK----YLYLLFSSDD--LMPFE-SWVFNTEAHPLP--------------------------------------- -------------------------------------VLHLGNITLPGSEPAQR-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Gasterosteus_aculeatus_MAN1A2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MKTPALLALSGR-------------RIPTLSPGA-----------------SSFPHHRA TLRLSEKFILLLILSAFITLCFGAFFFLPDNSKHKR-----------------------------------FDLGLEDVL IPHIDSPKEGKHTSGQVVIHGQ------------GGHDEHRHREEEESLRDKIRADHERALQEAKEKLRKSREELQAEIQ TEKNK--VMEDLKKKDAGPKPLPP--VPLPK-----------------------VVGVSDGEPPEPDAKERRDKIRE--- ----------------------------MMKHAWDSYRQYGWGHNELKPLAKKGHSTNIF--GN-SQLGA------TIVD ALDTLYIMGLHDEFKDGQDWIEQNLDFGVN-AEVSVFEVNIRFIGGLLAAYYLSG--------------QEMFKLKA-VQ LAEKLLPAFN-TPTGIPWAMVNLKSGVGRNWGWASAG-SSILAEFGTLHMEFVHLTYLTGNPAYYQK--VMHIRKLLAKM DRPNG-----------------------LYPNYLNPRTG-RWGQHHTSVGGLGDSFYEYLLKAWLMSDKTDT-EARRTYD DAIEAIERHLIRKSN---------GGLTFIGEWKNG-HLE-RKMG----------------------HLACFAGGMFALG AD-------------GSPDD-KAGHYLQLGAEIAHTCHESYDRTVLKLGPEAFKFDSGLEAVA------VRQNEKYYILR PEVIETYWYMWRFTHDPKYRQWGWEAA--Q-------AIDKYCRVSGG-FSGVKDVYSSNPTYDDV----------QQSF FLAETLK----YLYLLFSSDD--LMPFE-SWVYNTEAHPLP--------------------------------------- -------------------------------------VLHRRNITLPGSEPAQ--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Oryzias_latipes_MAN1A2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------IRFIGGLLAAYYLSG--------------QEVFKLKA-VQ LAEKLLPAFN-TPTGIPWAMVNLKSGVGRNWGWASAG-SSILAEFGTLHMEFVHLTYLTGNPVYYQK--VMHIRKLLAKM DRPNG-----------------------LYPNYLNPRTG-RWGQHHTSVGGLGDSFYEYLLKAWLMSDKTDT-EARKTYD DAVEAIERHLVRKSN---------GGLTFIGEWKNG-HLE-RKMG----------------------HLACFAGGMFALG AD-------------GSPDD-KAGHYLQLGAEIAHTCHESYDRTVLKLGPEAFKFDSGLEAVA------VRQNEKYYILR PEVIETYWYMWRFTHDPKYRQWGWEAA--Q-------AIDKYCRVSGG-FSGVKDVYSSNPTYDDV----------QQSF FLAETLK------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Ciona_intestinalis_MAN1A2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------GNPTDPDIIEKRESIKN--- ----------------------------MMKLAWKGYKDFAWGANELRPISKSRHSANIFG---SADTGA------TIVD ALDTLYIMGMHKEFKEGAEWVMG-LNMNSR-TDISVFEVNIRFIGGLLSAYFLSG--------------DTTLLNQA-KI ITDKLLPAFN-TATGIPYALINPTTGNVKNWGWASGG-SSILSEFGTLHLEFSMLSKATGNPVYLEK--VVKIREFLRKA DKPNG-----------------------LYPNYINPQTG-AWGQRHVSVGALGDSFYEYLLKSWVLSDKTDV-VARQMYD EAVEAIEKHVMGKSP---------GGLTYLGEWRSG-RLE-PKMG----------------------HLTCFAGGMFALG AE-------------GSK---DKDHYMKLGGEIAHTCHESYDKATLKLGPEAFHLSGGNEATA------LRANEKYYILR PEVIETYFYMWRLTKDPKYRQWGWDAAQ---------ALEKNCRTENG-YTGIKDVYAANPQYDDV----------QQSF FLAETLK----YLYLLFSDDD--LLNLN-EWVFNSEAHPLP--------------------------------------- -------------------------------------IIKQS-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Branchiostoma_floridae_MAN1A2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------MKFAWDNYVQYAWGQNELKPISKRGHSASIFG---NSAMGA------TIVD GLDTLYLMGLMDEYKKGRDWIATNLKMEAT-ADISVFEVTIRFVGGLLAAFAMTG--------------DQMFKDKA-VM IADKLLPAFN-TPTGIPWALVNTKRGNGRNWGWASGG-SSLLAEYGTLHLEFAYLTELTGNSVYLDK--VKRVREVISEL DKPDG-----------------------LYPIYINPKTG-KWGQNHASLGAMGDSFYEYLLKSWIMSGKIDN-NARRMYD QAMTVSCSN--------------------------------HKDS----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Homo_sapiens_MAN1B1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MAACEGRRSGALGSSQSDFLTP PVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGEN------YDNSKSWRR-------------------RSCWRKWKQ LSRLQRNMIL-FLLAFLLFCGLLFYINLADHWKALA----------------------------FRLEEEQKMRPEIAGL KPANPPVLPAPQKADTDPENLPEISSQKTQR--HIQRGPPHLQIRPPSQDLKDG--TQEEATKRQEAPVDPRPEGDPQRT VISWRGAVIEPEQGTELPSRRAEVPTKP-PLPPAR-------------------------TQGTPVHLNYRQKGVID--- ----------------------------VFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLG--------------LTLID ALDTMWILGLRKEFEEARKWVSKKLHFEKD-VDVNLFESTIRILGGLLSAYHLSG--------------DSLFLRKA-ED FGNRLMPAFR-TPSKIPYSDVNIGTGVAHPPRWTSDS---TVAEVTSIQLEFRELSRLTGDKKF-QE-AVEKVTQHIHGL SGKKDG----------------------LVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQET-QLLEDYV EAIEGVRTHLLRHSEP--------SKLTFVGELAHG-RFS-AKMD----------------------HLVCFLPGTLALG -----------------VYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGR--RDVEVKPADRHNLLR PETVESLFYLYRVTGDRKYQDWGWEILQ---------SFSRFTRVPSGGYSSINNVQDPQKPEPRD---------KMESF FLGETLK----YLFLLFSDDP-NLLSLD-AYVFNTEAHPLP--------------------------------------- -------------------------------------IWTPA-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Pan_troglodytes_MAN1B1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MAACEGRRSGALGSSQSDFLTP PVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGES------YDNSKSWRR-------------------RSCWRKWKQ LSRLQRNMIL-FLLAFLLFCGLLFYINLADHWKALA----------------------------FRLEEQQKMRPEIAGL KPANPPVLPAPQKADTDPENLPEISSQKTQR--HVQRGPPHLQIRPPSQDLKDG--TQEEATKRQEAPVDPHPEGDPQRT VISWRGAVIEPEQGTELPSRRAEVPTKP-PLPPAR-------------------------TQGTPVHPNYRQKGVID--- ----------------------------VFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLG--------------LTLID ALDTMWILGLRKEFEEARKWVSKKLHFEKD-VDVNLFESTIRILGGLLSAYHLSG--------------DSLFLRKA-ED FGNRLMPAFR-TPSKIPYSDVNIGTGVAHPPRWTSDS---TVAEVTSIQLEFRELSRLTGDKKF-QE-AVEKVTQHIHGL SGKKDG----------------------LVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQET-QLLEDYV EAIEGVRTHLLRHSEP--------SKLTFVGELAHG-RFS-AKMD----------------------HLVCFLPGTLALG -----------------VYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGR--RDVEVKPADRHNLLR PETVESLFYLYRVTGDRKYQDWGWEILQ---------SFNRFTRVPSGGYSSINNVQDPQKPEPRD---------KMESF FLGETLK----YLFLLFSDDP-NLLSLD-AYVFNTEAHPLP--------------------------------------- -------------------------------------IWTPA-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Macaca_mulatta_MAN1B1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------MAACEGRRSGALGSSQSDFLTP PVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGES------YDNSKSWRR-------------------RSCWRKWKQ LSRLQRNMIL-FLLAFLIFCGFLFYINLADHWKALA----------------------------FRLEEEQKMRPEITGL KPANPPVLPAPQKADTDPEDFTEISSQKSQR--RVQRGPPHLQIRPPSQDLKDG--TQEEAMKREEVPVDPRPEGDPQRT VISWRGAVIEPERGTELPSRKAAVPTKP-PLPPSR-------------------------TQGTPAHPNYRQKGVID--- ----------------------------VFLHAWKGYRKFAWGRDELKPVSRSFNEWFGLG--------------LTLID ALDTMWILGLRKEFEEARKWVSKKLHFEKD-VDVNLFESTIRILGGLLSAYHLSG--------------DSLFLRKA-ED FGNRLMPAFR-TPSKIPYSDVNIGTGVAHPPRWTSDS---TVAEVTSIQLEFRELSRLTGAKKF-QE-AVEKVTQHIHGL SGKKDG----------------------LVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQET-QLLEDYV EAIEGVRTHLLRHSEP--------SKLTFVGELAHG-RFS-AKMD----------------------HLVCFLPGTLALG -----------------VYHGLPASHMELARELMETCYQMNRQMETGLSPEIVHFNLYPQPGR--RDVEVKPADRHNLLR PETVESLFYLYRVTGDRKYQDWGWEILQ---------SFSRFTRVPSGGYSSINNVQDPQKPEPRD---------KMESF FLGETLK----YLFLLFSDDP-NLLSLD-AYVFNTEAHPLP--------------------------------------- -------------------------------------IWTPA-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Mus_musculus_MAN1B1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MYPP PA----------------PPPAPHRDFISVTLSLGES------YDNSKSRRR-------------------RSCWRKWKQ LSRLQRNVIL-FVLGFLILCGFLYSLHTADQWKALS----------------------------GRPAEVEKMKQEVL-- -----PVLPAPQKESAEQEGFADILSQKRQR--HFRRGPPHLQIRPPNTVSKDG--MQDDAKEREAALGKAQQEENTQRT VISWRGAVIEPEQATELPYKRAEASIKP-LVLASK-------------------------IWKEPAPPNERQKGVIE--- ----------------------------AFLHAWKGYQKFAWGHDELKPVSKTFSEWFGLG--------------LTLID ALDTMWILGLKQEFKQARKWVSENLDFQKN-VDVNLFESTIRILGGLLSTYHLSG--------------DSLFLTKA-ED FGKRLMPAFT-TPSKIPYSDVNIGTGFAHSPQWTSDS---TVAEVTSIQLEFRELSRLTGIKKF-QE-AVEEVTKHIHSL SGKKDG----------------------LVPMFINTNSGLFTHPGVFTLGARADSYYEYLLKQWIQGGKKET-QLLEDYV KAIEGIKAHLLRQSQP--------RKLTFVGELAHG-RFS-AKMD----------------------HLVCFLPGTLALG -----------------VHHGLPADHMDLARALMETCYQMNQQMETGLSPEIAHFNMYPRADH--KDVEVKPADRHNLLR PETVESLFYLYRVTRDRKYQDWGWEILQ---------SFNKYTRVPSGGYSSINNVQNSHKPEPRD---------KMESF FVGETLK----YLYLLFSDDL-ELLSLD-SCVFNTEAHPLP--------------------------------------- -------------------------------------IWAPA-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Rattus_norvegicus_MAN1B1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MYPP P-----------------PAPAPHRDFISVTLSLGES------YDNSKSRRR-------------------RSCWRKWKQ LSRLQRNVIL-FVLGFLILCGFLYSLQVSDQWKALS----------------------------GSRAEVEKMKLEVL-- -----PVLPAPQKESAEPEGFADILSQKRQR--HLRRGPPHLQIRPPNTVSKDG--MQDDAKEREAALGKAQQEENTQRT VISWRGAVIEPEQATEPPSKRAEASIKP-LFLASR-------------------------IWKEPAPPNERQKGVIE--- ----------------------------AFLHAWKGYQKFAWGHDELKPVSKTFSEWFGLG--------------LTLID ALDTMWILGLKQEFKEARKWVSENLDFQKN-VDVNLFESTIRILGGLLSAYHLSG--------------DSLFLSKA-ED FGNRLMPAFT-TPSKIPYSDVNIGTGFAHSPQWTSDS---TVAEVTSIQLEFRELSRLTGIKKF-QE-AVEEVTKHIHSL SGKKDG----------------------LVPMFINTNSGLFTHPGVFTLGARADSYYEYLLKQWIQGGKKET-QLLEDYV RAIEGIKAHLLRQSQP--------RKLTFVGELAHG-RFS-AKMD----------------------HLVCFLPGTLALG -----------------VHHGLPADHMDLARALMETCYQMNQQMETGLSPEIAHFNMYPRADH--KDVEVKPADRHNLLR PETVESLFYLYRVTKDRKYQDWGWEILQ---------SFNKYTRVPSGGYSSINNVQNSHKPEPRD---------KMESF FVGETLK----YLYLLFSDDL-ELLGLD-TCVFNTEAHPLP--------------------------------------- -------------------------------------IWSPA-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Bos_taurus_MAN1B1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MYP--PPAPARRDFISVTLSPGRS------YDGGQGLRR-------------------RSCWRKWKQ LSRLQRTVVL-FLLVVVMLFGLLSYVHVADEWT--------------------------------AVDSRS---AAAGQM RPANPPVLPAPQKAAENPEAVAGLSPQKPQR--HFRRGPPNLQIRAPDGDPQER--RQDRAQRRAEVVGEAGWGAEAQRD GLRWRGAGTKLEQGPRHPPKKAEFFGWPFQQQALR-------------------------IRASRTPQNERQKAVVD--- ----------------------------AFLHAWAGYRKFAWGHDELKPLTRSFSEWFGLG--------------LTLID ALDTMWILGLKKEFQEARKWVSKKLRFRKN-VDVNLFESTIRILGGLLSAFHLSG--------------DILFLKKA-ED FGNRLMPAFR-TPSKIPYSMVNIGTGVAHPPRWTSDS---TVAEVTSIQLEFRELSRLTGDKKF-QE-AAEEVTRRVHAL HGKLDG----------------------LVPMFINTNSGSFTHLGMFTLGARADSYYEYLLKQWIQGGKKER-QLLEDYL EAVDGIRKHLLARSEP--------RKLTFVGELNHG-RFS-AKMD----------------------HLVCFLPGTLALG -----------------AHHGLPAEHMELAQALMDTCYQMYRQMETGLSPETAHFNLHHTKIL--KDVQVKAADRHNLLR PETVESLFYLYRLTGDRKYQDWGWEILH---------SFNTYTRVPSGGYSSISNVQDPRHPQPRD---------KMESF FLGETLK----YLYLLFSDDP-DLLSLD-TYVFNTEAHPLP--------------------------------------- -------------------------------------IWAPS-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Gallus_gallus_MAN1B1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MYAAAAAAVAASPPRRDFISVTLSPEEAVGAGGYNNS-KAWRR-------------------RSCWRKWKQ LSRLQRSIIL-FLFAFLTVCGVISYTSVREPWKSLT----------------------------SKSSDEHGTEPDAPGL RLANPAVLPAPQKADANAGDYPELSPQKKPKLPHGRRNPSNFQIKPPWGDVRLQ--TRHDTRKAVEEPAQADKQEKTEKS VISWRGAVIEPDQSSEPPSSRVKEPEKP-SSVEGE-------------------------SQKEPVPINERQMAVIE--- ----------------------------AFRHAWKGYKDFAWGHDELKPLSKSYSEWFGLG--------------LTLID ALDTMWILGLREEFEEARKWVANDLAFDKN-VDVNLFESTIRILGGLLSTYHLSG--------------DSLFLEKA-KD IGNRLMPAFK-TPSKIPYSDVNIGRGTAHPPRWTSDS---TVAEVTSIQLEFRELSRLTGDEKY-QK-AVDEVMKHVHTL SGKNDG----------------------LVPMFINTNSGQFTHLGVYTLGARADSYYEYLLKQWIQGGKTEN-ELLEDYM KAIEGVKKHLLQRSQP--------KKLTFVGELAHG-HFS-AKMD----------------------HLVCFLPGTLALG -----------------AHNGLTADHMKLAEALIETCYQMYAQVETGLSPEIVHFNLHAQKGH--KDVEIKPADRHNLLR PETVESLFYMYRFTGDKKYQDWGWEILQ---------NFNKYTRVPTGGYTSINNVQNPSNPEPRD---------KMESF FLGETLK----YMFLLFSDDI-DLINLD-KYVFNTEAHPLP--------------------------------------- -------------------------------------IWVPA-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Taeniopygia_guttata_MAN1B1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------PRRDFISVTLGPEEAVGVGGYNNS-KAWRR-------------------RSCWRKWKQ LSRLQRSVIL-FLFAFLALCGAISYTSMGETWKSIT----------------------------NKSLDDQRKEQEIPRL KLANPAVLPAPQKADANHRDYPELSLQKPPKLPHVRRGPSNLQIKAPQRDTRLK--TRHDTMRAVEELVEVHKVEKTEKS IISWRGAVIEPDQSTEPPSSKIMEPEKP-SSVEAE-------------------------DRKEAVPINERQLAVIE--- ----------------------------AFRHAWKGYKDFAWGHDELKPLSKSYSEWFGLG--------------LTLID ALDTMWILGLKEEFEEARKWVANDLVFDKN-VDVNLFESTIRILGGLLSTYHLSG--------------DSLFLEKA-KD IGNRLMPAFK-TPSKIPYSDVNLGRGTAHPPRWTSDS---TVAEVTSIQLEFRELSRLTGDEKF-RK-AVDEVMKHVHIL SGKNDG----------------------LVPMFINTNSGQFTHLGVYTLGARADSYYEYLLKQWIQGGKKEN-ELLEDYT RAIEGVKKHLLQRSEP--------KKLTFVGELAHG-HFS-AKMD----------------------HLVCFLPGTLALG -----------------AHNGLAADHMKLAETLIETCYQMYAQVETGLSPEIVHFNLHAQKGH--KDIEIKPADRHNLLR PETVESLFYMYRFTGDKKYQDWGWEILQ---------NFNRYTRVPTGGYTSINNVQNPSNPEPRD---------KMESF FLGETLK----YMFLLFSDDT-DLINLD-KYIFNTEAHPLP--------------------------------------- -------------------------------------IWVPA-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------- >Anolis_carolinensis_MAN1B1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------MQVRNKIITSTSEP---------------------------------------------- -----GFICI-FFFFFF--------------------------------------------------------------- -------------------------------------------------------------------------------- --SWRGAVIEPDQGTELPSSKIKEPDKP-SPMEAE-------------------------DQKEPVPFNERQLAVIE--- ----------------------------AFRHAWKGYKEFAWGHDELKPISKSFNEWFGLG--------------LTLID ALDTMWIMDLKEEFAEARQWVATELRFDKN-VDVNLFESAIRILGGLLSTYHLSG--------------DSLFLEKA-KD IGSRLMPAFN-TPSKIPFSDVNIGRGTAHPPRWTSDS---TVAEVTSIQLEFRELSRLTGEEKY-QK-AVDGVMEHVHTL AGKNDG----------------------LVPMFINTNTGQFTHLGVYTLGARADSYYEYLLKQWIQGGKKEN-ALLEDYV KGIEGVKAHLLRKSQP--------KRLTFVGELAHG-RFS-AKMD----------------------HLVCFLPGALALG -----------------AHNGLPADHMTLAAELAETCYQMYAQVETGLSPEIVHFNLHAQKNR--KDVEIKAADRHNLLR PETVESLFYLYRFTGDKKYQDWGWEILQ---------SFNRYTRVPTGGYTSINNVQNPSSPEPKD---------KMESF FLGETLK----YFFLLFSDDV-NLINLD-KFVFNTEAHPLP--------------------------------------- -------------------------------------IWPSA-------------------------------------- ---------------------------------------------------