>HUMAN_NFE2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------MSPCPPQ QSRNRVIQLSTSELGEMELT-WQEIMSITELQGLNAPSEPSFEPQAP-------------APYLGPPPPT---------- ----------------TYCPCSIHPDSGFPLPPPPYELPASTSHVPDPPYSYG--------------------------- -------------------------------------------------------------------------------- ---NMAIPVSKPLSLSGLLSEPLQDPLALLDIGLPAGPP----KPQEDP------------------------------- --------------------------------------ESDSG----------LSLNYSDAESLELEGTEAGRRRSEYVE MYPVEY---------------------------PYSLMPNSLAHSNYTLP------------AAETPLALEPS------- --------------------------------------------------------------------------SGPVRA KPTARGEAG---------------------------------------------SRDERRALAMKIPFPTDKIVNLPVDD FNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLTNERERLLRARGEADRTLEVMRQQLTEL YRDIFQHLRDESGNSYSPEEYALQQAADGTIFLVPRG------------------------------------------- ------------------------------------------------TKMEATD------------------------- ------------------- >MOUSE_NFE2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------MPPCPPQ QNRNRLSQLPVGELGEMELT-WQEIMSITELQGLNVPSETSFEPQAP-------------TPYPGPLPPP---------- ----------------TYCPCSIHPDAGFSLPPPSYELPASTPHVPELPYSYG--------------------------- -------------------------------------------------------------------------------- ---NVAIPVSKPLTLSGLLNEPLPDHLALLDIGLPVGQP----KPQEDP------------------------------- --------------------------------------ESDSG----------LSLNYSDAESLELEGMEAGRRRSEYAD MYPVEY---------------------------PYSLMPNSLAHPNYTLP------------PTETPLALESS------- --------------------------------------------------------------------------SGPVRA KPAVRGEAG---------------------------------------------SRDERRALAMKIPFPTDKIVNLPVDD FNELLAQYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLSSERERLLRARGEADRTLEVMRQQLAEL YHDIFQHLRDESGNSYSPEEYVLQQAADGAIFLVPRG------------------------------------------- ------------------------------------------------TKMEATD------------------------- ------------------- >RAT_NFE2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------MPPCPPQ PNRNRLPQLPTGELGEMELT-WQEIMSITELQGLNVPSEPSFEPQAP-------------TPYPGPLPPP---------- ----------------TYCPCSIHPDAGFTLPPPPYELPASTPHAPDLPYSYG--------------------------- -------------------------------------------------------------------------------- ---NIAIPVSKPLTLSGLLNEPLPDPLALLDIGLPVGQP----KPQEDP------------------------------- --------------------------------------ESDSG----------LSLNYSDAESLELEGTEAGRRRSEYVD MYPVEY---------------------------PYSLMPNSLAHPNYTLP------------PTETPLVLESS------- --------------------------------------------------------------------------SGPVRA KPAVRGEAG---------------------------------------------SRDERRALAMKIPFPTDKIVNLPVDD FNELLAQYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLGSERERLLRARGEADRTLEVMRQQLTEL YHDIFQHLRDESGNSYSPEEYVLQQAADGAIFLVPRG------------------------------------------- ------------------------------------------------TKMEATD------------------------- ------------------- >DOG_NFE2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------MPPCPPQ QSRDRGTQLPTPELGEMELT-WQEIMSITELQGLNAPSEPSFETPAP-------------APYPGPPPPP---------- ----------------TYCPCSIHPDAGFPLPPTPYELPAAASHVPDPSYSYG--------------------------- -------------------------------------------------------------------------------- ---NMAIPVSKPLTLSGLLSETLPDPLALLDIGLPAGPP----KPQEDP------------------------------- --------------------------------------ESDSG----------LSLNYSDAESLELEGTEAGRRRSEYVE MYPVEY---------------------------PYSLMPNSLAHPNYALP------------PAETPLALEPS------- --------------------------------------------------------------------------AGPVRA KSTARGEAG---------------------------------------------SRDERRALAMKIPFPTDKIVNLPVDD FNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLGNERERLLRARGEADRTLEVMRQQLTEL YCDIFQHLRDEAGNSYSPEEYALQQAADGAIFLVPRG------------------------------------------- ------------------------------------------------TKVEAED------------------------- ------------------- >HORSE_NFE2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------MEPNQKAQVFLQILSLLPLLKWENLGDRKIVAS TLSAQQWPGGGARPSPALRGSRDPHPGGVSPGPASPETAPGASSLSSLCSDPATGCWGCLGFGGPWTRPWPSRMPPCPPQ QSRNRVTQLPTPELGEMELT-WQEIMSITELQGLNAPTEPSFEPPAP-------------APYPGPPPPS---------- ----------------TYCPCSIHPDAGFPLPPPPYELPAPTSHVQDPPYSYC--------------------------- -------------------------------------------------------------------------------- ---NMAIPVSKPLTLSGLLSEPLPDPLALLDIGLPAGPP----KPQEDP------------------------------- --------------------------------------ESDSG----------LSLNYSDAESLELEGTEVGRRRGEYVE MYPVEY---------------------------PYSIMPNSLAHPNYALP------------PAETPLALEPS------- --------------------------------------------------------------------------SGPVRA KPTARGEVG---------------------------------------------SRDERRALAMKIPFPTDKIVNLPVDD FNELLARYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLGSERERLLRARGEADRTLEVMRQQLTEL YRDIFQHLRDEAGNNYSPEEYVLQQAADGAIFLVPRG------------------------------------------- ------------------------------------------------PKVEATD------------------------- ------------------- >PLATYPUS_NFE2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------FPTDKIVNLPVDD FNELLGRYPLSESQLALVRDIRRRGKNKVAAQNCRKRKLETLVQLERELAELSTRRERLLRARGEAGRTLGLLRQQLGDL YRDVFARLQDEEGNGYSPDEYVLQQAADGTVFLAPRG------------------------------------------- ------------------------------------------------TPAQED-------------------------- ------------------- >Fugu_NFE2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MTANFPGARPHGTLHDCEMDVTWQEL MAITELQ-FDAPAEGSFEAMQYQSMEAMAPMGGYGMPSSHSALPPAP-------------SHRLGGNTEA---------- ----------------MYSHAETQLSQRVLPAPSHPQLSVMAPGEQNTFPSTGQVQRGPSAH------------------ -------------------------------------------------------------------------------- --FSQGPSQHMLWSVHEQALHARSADDLESDSGLSLGSS----PSLASP------------------------------- --------------------------------------DYPGGSGAPCYQSAEMGPTYSDGEAD--MTERVQTARIHYSM EYQSQC---------------------------HTYVQSAGHPSNFATQP------------VVAHAQTHWST------- ----------------------------------------------------------------KEPDQTAAVNSLYVDP GVSSRGSPHPSSFPKPQASVS----------------------------T--PLSRDERRAKALKIPFPMDQIINLPVDD FNELLTQYTLTDSQLALVRDIRRRGKNKVAAQNCRKRKLESIIHLETELNQLQTQRELLSKQRFEFTRSLAFIKRRLSDL YSQVFSRLRDEDGQPYSVEDYALQQTPDGKVYLVPHS------------------------------------------- ------------------------------------------------MKT----------------------------- ------------------- >STICKLEBACK_NFE2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MDVAWQEL MAIPELQEFEVSSAGSYETAQYQTMEPMVPVGGYEMAQSHPEALPAACALSTADAYDG-CFHRLGDNAGA---------- ----------------MYGHADSQHFQRMLPASGHAQPSHVALREQMNASGAGQGHRRAHAG------------------ -------------------------------------------------------------------------------- --LSQDPRRHMLWTTHGHGAHVLPADEIESDSGLSLGSS----PPLASP------------------------------- --------------------------------------DNPVG-GAPGYQRVDVGVTYSDGEPDS-MAEQARRASAHYSM DYQSQS---------------------------YSYLHPGGHP-AYSTEP------------NLSHPAPIALSR------ --------------------------------------------------------------PVKPPGQNCALGHLSIDM GASSRGSSQYNVYAKPQGSIS----------------------------TPAPLSRDERRAMSLKIPFPMEKIVNLPVDD FNELLTQYTLTDHQLALVRDIRRRGKNKVAAQNCRKRKLESIIHLEKELNQLQAQREHLARERVEFQRSLTFIKCHLTDL YSQVFSHLRDEEGQPFSIDEYALQQTLDGKIYLVPNA------------------------------------------- ------------------------------------------------TMQKR--------------------------- ------------------- >TETRAODON_NFE2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MDVAWQEL MAITELQ-FDAPTEGSFEAMQYQSMEAMTPMEGYGMGSSQSVPPASGESYNGCYHNEVPLGHRSGNNMDA---------- ----------------MYSHTETQLSQRVLPAPFHAQLTVIAPGEQNSFP-------GP--------------------- -------------------------------------------------------------------------------- ---SQGLSQNMLWSMHERALHTRSADDLESDSGLSLGSS----PSLASP------------------------------- --------------------------------------DYPGGSSAPCYQSADVGPTYSDGEAD--MTERVQSAHIHYSM EYQSQC---------------------------HTYVQSARQPSHFSTQP------------IASHTQTQWSS------- ----------------------------------------------------------------KDPDQAGAVNSLHVDP RVPSRGSPHPNSFTKPQTSMP----------------------------T--PLSRDERKAKALNIPFPMDQIINLPVDD FNELLTQYTLTDTQLALVRDIRRRGKNKVAAQNCRKRKLESIIHLEAELNQLKTQKEILSKQRFEFNRSLAFIKRRLSEL YSQVFSRLRDEDGQPYSVKDYSLQQTPDGKVYLVPHS------------------------------------------- ------------------------------------------------MKTWGK-------------------------- ------------------- >HUMAN_NFE2L1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQL PPLR-----------EIILGPSSAYTQTQFHNLRNTLDGYGIHPKSIDLDNYFT-----ARRLLSQVRALDRFQVPTTEV NAWLVHRDPEGSVSGS-QPNSGLALESSSGLQDVTGPDNG------VRESETEQGFGEDLEDLGAVAPP----------- -----------------VSGDLTKEDIDLIDILWRQDIDLGAGREVFDYSHRQKEQDVEKEL-----RDGGE-QDTWAGE GAEALARN--LLVDGETGESFPAQVPSGEDQTALSLEECLRLLEATCPFGENAEF-PADISSITEAVPSESEPPALQNNL LSPLLTGTESPFDLEQQWQDLMSIMEMQAMEVN-TSASEILYSAPPGDP----------LSTNYSLAP-NTPINQNVSLH QASLGGCSQDF-LLFSPEVE---SLPVASSSTLLPLAPSNSTSLNSTFGSTNLTGLFFPPQLN-GTANDTAGPELPDPLG GLLDEAMLDE----ISLMDLAIEEGFNPVQASQLEEEFDSDSGLSLDSSH-------SP---SSLSSSEGSSSSSSSSSS SSSSASSSASSSFSEEGAVGYSSDSETLDLEEAEGAVG-YQPEYSKFCR-MSYQDPAQLSCLPYLEHVGHNHTYNMAPSA LDSADLPPPSALKKGSKEKQA--------------------------DFLDKQMSRDEHRARAMKIPFTNDKIINLPVEE FNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMKQKVQSL YQEVFGRLRDENGRPYSPSQYALQYAGDGSVLLIPRT------------------------------------------- ------------------------------------------------MAD-QQARRQERKPKDRRK------------- ------------------- >MOUSE_NFE2L1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQL PPLR-----------EIILGPSSAYTQTQFHNLRNTLDGYGIHPKSIDLDNYFT-----ARRLLSQVRALDRFQVPTTEV NAWLVHRDPEGSVSGS-QPNSGLALESSSGLQDVTGPDNG------VRESETEQGFGEDLEDLGAVAPP----------- -----------------VSGDLTKEDIDLIDILWRQDIDLGAGREVFDYSHRQKEQDVDKEL-----QDGREREDTWSGE GAEALARD--LLVDGETGESFPAQFP-------------------------------ADVSSIPEAVPSESESPALQNSL LSPLLTGTESPFDLEQQWQDLMSIMEMQAMEVN-TSASEILYNAPPGDP----------LSTNYSLAP-NTPINQNVSLH QASLGGCSQDF-SLFSPEVE---SLPVASSSTLLPLVPSNSTSLNSTFGSTNLAGLFFPSQLN-GTANDTSGPELPDPLG GLLDEAMLDE----ISLMDLAIEEGFNPVQASQLEEEFDSDSGLSLDSSH-------SP---SSLSSSEGSSSSSSSSSS SS--ASSSASSSFSEEGAVGYSSDSETLDLEEAEGAVG-YQPEYSKFCR-MSYQDPSQLSCLPYLEHVGHNHTYNMAPSA LDSADLPPPSTLKKGSKEKQA--------------------------DFLDKQMSRDEHRARAMKIPFTNDKIINLPVEE FNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMKQKVQSL YQEVFGRLRDEHGRPYSPSQYALQYAGDGSVLLIPRT------------------------------------------- ------------------------------------------------MAD-QQARRQERKPKDRRK------------- ------------------- >RAT_NFE2L1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------MEVN-TSASEILYSAPPGDP----------LTTNYSLAP-NTPINQNVSLH QASLGGCSQDF-SLFSPEVE---SLPVASSSTLLPLVPSNSTSLNSTFGSTNLAGLFFPSQLN-GTANDTSGPELPDPLG GLLDEAMLDE----ISLMDLAIEEGFNPGQASQLEEEFDSDSGLSLDSSH-------SP---SSLSSSEGSSSSSSSSSS ----ASSSASSSFSEEGAVGYSSDSETLDLEEAEGAVG-YQPEYSKFCR-MSYQDPSQLSCLPYLEHVGHNHTYNMAPSA LDSADLPPPSTLKKGSKEKQA--------------------------DFLDKQMSRDEHRARAMKIPFTNDKIINLPVEE FNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKQEIYRTVTD-------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------- >DOG_NFE2L1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQL PPLR-----------EIILGPSSAYTQTQFHNLRNTLDGYGIHPKSIDLDNYFT-----ARRLLSQVRALDRFQVPTTEV NAWLVHRDPEGSVSGS-QPSSGLTLESSSGLQDVTGPDNG------VRESETEQGFSEDLEDLGAVAPP----------- -----------------VSGDLTKEDIDLIDILWRQDIDLGAGREIFDYSHRQKEQDVDKDL-----RDGAEQEDTWSGE GAEALARN--LLVDGETGESFPAQFP-------------------------------ADISSITEAVPSESEPPGLQNNL LSPLLTGTESPFDLEQQWQDLMSIMEMQAMEVN-TSTNEILYNAPPGDP----------LSTNYSLAP-NTPINQNVSLH QASLGGCSQDF-SLFSPEAE---SLPVASGSTLLPLLPSNSTSLNSSFGSTNLAGLFFPPQLN-GTANDTAGPELPDPLG GLLDEAMLDE----ISLMDLAIEEGFNPVQASQLEEEFDSDSGLSLDSSH-------SP---SSLSSSE----------- --------ASSSFSEEGAVGYSSDSETLDLEEAEGAVG-YQPEYSKFCR-MSYQDPSQLSCLPYLEHVGHNHTYNMAPSA LDSADLPPPSGLKKGSKEKQA--------------------------DFLDKQMSRDEHRARAMKIPFTNDKIINLPVEE FNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMKQKVQSL YQEVFGRLRDENGRPYSPSQYALQYAGDGSVLLIPRT------------------------------------------- ------------------------------------------------LAD-QQARRQERKPKDRRK------------- ------------------- >HORSE_NFE2L1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQL PPLR-----------EIILGPSSAYTQTQFHNLRNTLDGYGIHPKSIDLDNYFT-----ARRLLSQVRALDRFQVPTTEV NAWLVHRDPEGSVSGS-QPSSSLILSVSSGHQDVTGSDNW------GRESKSVQRFMEDLEDFEAVAPP----------- -----------------VSGDLSREDIDLIDILWRQDIDLGAGREIFDYSHRQKEQDVDKEL-----QDGAEQEDTWPGE GAEALARN--LLVDGETGESFPAQVPGGEDQRALSLEECLRLLEATCPFGENAEF-PADISSITEAVPSESEPPGLQNNL LSPLLTGTESPFDLEQQWQDLMSIMEMQAMEVN-TSTSEILYNAPPGDP----------LSTNYSLAP-NTPINQNVSLH QASLGGCSQDF-SLFSPEVE---SLPVAGSSTLLPLAPSN-TSLSSTFESTNLLG-FFPPQLN-GTSPDTTDPELPDPVV GVL?EAMLD?----ISLIDLASE?RLIP-AASQLEKKIDSYSCISWDSFI?PFLPE-QP?--RQLSSSSSSSSSSPLLSS SS--ASSSASSSFSEEGAVGYSSDSETLDLEEAEGAVG-YQPEYSKFCR-MSYQDPSQLSCLPYLEHVGHNHTYNMAPSA LDSADLPPPSTVKKGSKEKQA--------------------------DFLDKQMSRDEHRARAMKIPFTNDKIINLPVEE FNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLQEKVEFLRSLRQMKQKVQSL YQEVFGRLRDENGRPYSPSQYALQYAGDGSVLLIPRT------------------------------------------- ------------------------------------------------LAD-QQARRQERKPKDRRK------------- ------------------- >PLATYPUS_NFE2L1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----GSCAQDC-ALFGGAAERESPPPGPGGAPLLPLTPGNATGLNSTFGATNLTGLFLPAPLN-GSANGTAGPELPDPLG GLLDEAMLDE----ISLMDLVIEEGFNPVQASRLREELDSDSGLSLDSSHSPASSSGSPSSSASSSSSASSSSSSSSSSS SSSSSSSSSSSSSSEEGAVGYSSDLETLDPEEAEGAVGGYQPEYSKLCR-MDSRDPAPLRYLPYLEHVDHNHTYNMVP-- -------------EPSKEKRA--------------------------DFLDKQMSRDEHRARAMKIPFTNDKIINLPVEE FNELLSKYQLSDAQLGLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKAQLLREKVEFLKSLRQMKQKVQSL YQEVFGRLRDENGQPYSPSRYALQYASDGSVILIPRA------------------------------------------- ------------------------------------------------LAD-QQARRQDRKQKDRRK------------- ------------------- >ZEBRAFINCH_NFE2L1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------PDPLG GLLDEAMLDE----ISLMDLAIEEGFNPVQASQLEEEFDSDSGLSLDSGH-------SP---ASLSSSEASSSSSSSSS- ------SSSSSSFSEEGAVGYSSDSENVDLEEAEGAVG-YQPEYSKFCR-MSYQDPAQLHYLPYLEHVGHNHTYNMAPGA LDPEEPKAPGAGKKSGKEKPS--------------------------ELLDKQLSRDEHRARAMKIPFTNDKIINLPVEE FNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRMLDTILNLERDVEELQRDKSKLLREKVEFLKSIRQMKQKVQSL YQEVFGRLRDEQGRPYSPSRYALQYGSDGSVLLIPRA------------------------------------------- ------------------------------------------------PAD-QERRREKKEEKEKQKLFRGSKQLLERFP ------------------- >Human_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRK EYELEKQKKLEK-ERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGS-ANYSQVAHIPKSD---------- --------------ALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATN-----QAQSPETSVAQVA PVDLDGM------------------------------------------------------------------------- -QQDIEQVWEELLSIPELQ-CLNIENDKLVETTMVPSPE-AKLTEVDN-----------YHFYSSIP----SMEKEVGNC SPHFLNAFEDSFSSILSTEDPN---------QLTV--NSLNSDATVNTDFGDEFYSAFIAEPSISNS-MPSPATLSHSLS ELLNGP--------IDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSP------------SVASPEHSVESS-SYGDT LL------------------GLSDSEVEELDSAPGSVKQNGPKT-PVHSSGDMVQPLSPSQGQSTHVHDA-QCENTPEKE LPVSP-GHRKTPFTKDKHSSR----------------------------LEAHLTRDELRAKALHIPFPVEKIINLPVVD FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTL YLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKS------------------------------------------- ------------------------------------------------KKPDVKKN------------------------ ------------------- >Mouse_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQK DYELEKQKKLEK-ERQEQLQKEQEKAFFAQFQLDEETGEFLPIQPAQHIQTDTSGS-ASYSQVAHIPKQD---------- --------------ALYFEDCMQLLAETFPFVDDH-------ESLALDIPSHAESSVFTAPH-----QAQSLNS-SLEAA MTDLSSI------------------------------------------------------------------------- -EQDMEQVWQELFSIPELQ-CLNTENKQLADTTAVPSPE-ATLTEMDSN----------YHFYSSIS----SLEKEVGNC GPHFLHGFEDSFSSILSTDDAS---------QLT----SLDSNPTLNTDFGDEFYSAFIAEPSDGGS-MPSSAAISQSLS ELLDGT--------IEGCDLSLCKAFNPKHAEGTMEFNDSDSGISLNTSP------------SRASPEHSVESS-IYGDP PP------------------GFSDSEMEELDSAPGSVKQNGPKAQPAHSPGDTVQPLSPAQGHSAPMRES-QCENTTKKE VPVSP-GHQKAPFTKDKHSSR----------------------------LEAHLTRDELRAKALHIPFPVEKIINLPVDD FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRRLSTL YLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKS------------------------------------------- ------------------------------------------------KKPDTKKN------------------------ ------------------- >Rat_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQK DYELEKQKKLEK-ERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQTDTSGS-VSYSQVAHIPKQD---------- --------------ALYFEDCMQLLAETFPFVDDH-------ESLALDIPSHVESSVFTTPD-----QAQSLDS-SLETA MTDLSSI------------------------------------------------------------------------- -QQDMEQVWQELFSIPELQ-CLNTENKQQAETTTVPSPE-ATLTEMDSN----------YHFYSSIP----SLEKEVDSC SPHFLHGFEDSFSSILSTDDAS---------QLN----SLDSNPTLNTDFGDEFYSAFLAEPSGGGS-MPSSAAISQSLS ELLGGP--------IEGCDLSLCKAFNQKHTEGTVEFNDSDSGISLNTSP------------SRASPEHSVESS-IYGDP PP------------------GFSDSEMEELDSAPGSVKQNGPKAQPTHSSGDTVQPLSPAQGHSAAVHES-QCENTTKKE VPVSP-GHQKVPFTKDKHSSR----------------------------LEAHLTRDELRAKALHIPFPVEKIINLPVDD FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRKLSTL YLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKS------------------------------------------- ------------------------------------------------KKPDTKKN------------------------ ------------------- >Dog_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MRSLLEKLG----KDMDLIDILWRQDIDLGVSREVFDFSQRRK EHELEKQKKLEK-ERQEQLQKEQEKAFFAQLQLDEETGEFLPVQPAPHIPSETSAS-ANYSQVPHIPKPD---------- --------------ALYFDDCMQLLAETFPFVDDNEVSSAAFQSLVPDIPSQIENPVFIAPN-----QAQSPQTLAVQSV IADLDNM------------------------------------------------------------------------- -QQDIEQVWEELLSIPELQ-CLNIQNDKLVETSMVPSPE-TKMTEIDNN----------YHFYPSMP----SLEKEVGNC SPPFLSAFEDSFSSILSTEDSS---------QLTV--NSLNSDATINTDFGDEFYSAFIAEPSSSNS-MPSSASFSQSLS ELLNGP--------IDVSDLSLCKAFNQNHPEST-EFNDSDSGISLNTSP------------GMASPEHSVESS-VYGDT AL------------------GFSDSEMEETDSAPGSVKQTGPKTQPGQSAGDPAQPPSPSPGPSAPAHDA-QCENTPKKE SPVNP-GHRKAPFTKDKHSSR----------------------------LEAHLTRDELRAKALHIPFPVEKIINLPVDD FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTL YLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKS------------------------------------------- ------------------------------------------------KKPDIKKN------------------------ ------------------- >HORSE_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDLIDILWRQDIDLGVSREVFDFTQR-L QHELEKQKTLERQERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHISSETSGS-ANFSQVSHIPKPD---------- --------------ALNFDDCMQLLAETFPFVDDNEVSPATFQSLVPDIPSNIESPDFIAPN-----QAQSPETLVLQPA VADSDNM------------------------------------------------------------------------- -QQDLEQVWEELLSIPELQ-CLNIQNDKLVETSTVPSSE-TKVTEIDNN----------YHFYSSIP----SLEKEVGNC SPQLLNAFDDSFSSILSTEDTS---------QLTM--NSLNSEATINPDFGDGFYSAFV-EPSVSSS-MPSSATVSQSLS ELLNGP--------IDVSDLSLCKAFNQNHPESTSEFNDSDSGISLRTSP------------SMASPEHSVESS-TYEDT PL------------------GFSDSEMEETDSAPGSVKQNGPKTQPVQSSGDTVQPMSPSQGHSVPVHDA-QRENTPKKE VPISP-GHRKTPLTKDKHSSR----------------------------LEVHLTRDELRAKALHIPFPVEKIINLPVED FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTL YLEVFSMLRDEDGRPYSPSEYSLQQTRDGSVFLVPKS------------------------------------------- ------------------------------------------------RKTDVKK------------------------- ------------------- >Opossum_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MNLIDILWRQDIDLGARREVFDFSQRRK EHELEKQKKLEK-ERQEQLQKEQEKAFLAQLQLDEETGEFLPIQPAQHIEPSTS---ASYSQAADIPKAD---------- --------------ALFFDDCMQLLAETFPFVEDNEVSSATFQSLVPDHID--SNPVFITSS-----QAQLPESSVLQSI VENN---------------------------------------------------------------------------- -MQDIEQVWEELLSIPELQ-CLNIENDKLAEATIVPSPE-AKPTEINDS----------YNFYTSLS----TMEKEVATC NPDFLSAFEDSFGNILPTEDPN---------QLRM--NSLNSNATINTDFCEEFYSTFIAETNINNS-MPSPAHISQSLS ELLNEP--------IDISDLSLCKAFNSNPPENPPECNDSDSGISLNTSS------------NMASPEHSVESS-LYGDT PL------------------GFSDSEMEDVDSAPGSTQQSGARMQPVPFQEDMPYPVSPTQGPTVPAPDALQSVSTPKRE SPTSP-GHQKVPFTKDKHSGR----------------------------LESHFTRDEMRAKALHIPFPVEKIINLPVDD FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLRERGENDKSLHLLKKQLSTL YLEVFSMLRDENGEPYSPSEYSLQQTRDGNVFLVPKS------------------------------------------- ------------------------------------------------KKPDIKRN------------------------ ------------------- >Platypus_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MLRAHVRCQSRRECHRTGFPGCEVRPEPNAGYRRTDGS WVAEAPLNQKPPPTPAFSSRGQVDHSPSFDFKHFPLPISYRPAQVEGFGRRKPLMRESRLWTETFDPSTTRSPVSINFRL PFPLPTSTSHASREAQVRYPRAARAVGHPAVAVTVFERSQSAAPILERGRQLTSHGGGPGSGAGTPGQQERDRVASRSRG TRREAGSSGHVSRRCPRCQRARVRRSLICLICLLRSGPGDLMSPGKQPARNPILVRGPKKESSMSQSSTCCPKEFGLWNF SNRKLPTEPGGVYSQALASLAWCSWLPVFSAGAQRQKPGFDLHPSTFRLGAGLRGCSRSICYLYIGQEEAELEKIYLTLA RQGEKSMTLDCTWLGSKVKNQEIHGLISEKVLFSAGVVRFTILSKLIGLDTDMNLIDILWRQDIDLGAGREVFDFCQRQK EYELEKQKKLEK-ERQEQLQKEREQALLAQFQLDEETGEFLPIQPARPSQLEGGDGPAAFSQSPPTPKPD---------- --------------ALTFDDCMQLLTETFPFVDDNEVAPATLQSLSPPPAE--SSPVFVPPSP----TPAPAEAPVLEPA ATDSAAM------------------------------------------------------------------------- --QDIEQVWEELLSIPELQ-CLNIQNDKQAEAAPLPSPE-PKSGAADRP----------YGFYDVLSPLACTIEKEMSDS SPAFLGAFEG---SALPTQDLS---------VSGA--CAQPPSPSLGPDFCEDFYTTFVVELEPGAEGAGAP---SRLLT DLLNEP--------VDLADLALCKAFATPRPCGRPESNDADSGISLNTSP------------AAASPEPLADSV--DGDA AP------------------GSSDSETDDVDSGP----PGGAKIRPHAG------------------AEGGRQADPPKKE VLAGR-GPP--PGTRDRPAGR----------------------------LEAHFTRDEQRAKALQIPFPVEKIINLPVDD FNEMMSKEQFSEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGEHDLSLRLLKQQLSSL YLEVFSMLRDQDGQPYSPADYSLQQTRDGHVFLVPKS------------------------------------------- ------------------------------------------------KKPVRAMQEQLEEKEKRV-------------- ------------------- >Zebrafinch_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MNLIDILWRQDIDLGARREVFDSRQRQK EYELEKQKKLEK-ERQEQLQKEQEEALLAQLELDEETGEFVPVQPAQCIQSENPEPPVAFSQTTEPSKQEAE-------- --------------ALSFDDCMQLLAEAFPFIDEHEASSAAFQSVAPAQVN--SNPPFVSSD-----QIQPPESPDLVQP TDAEN--------------------------------------------------------------------------- -MQNIEQVWEELLSLPELQ-CLNIENDNLAEVSTVTSPE-PKPAEMHNS----------YSYCSSLP----MLKKD---C SPDFLDGMEGTFSGILPPEDTS---------QLSV--NSLNDTSPSNSDFCEDFYSTFIDTKVNGD--AAATNTISQSLA EILSEP--------IDLSDFALCKAFNGNRSGTRAEGTDSDSGISLNASS------------SVASPEHSVQSS-ACADK TL------------------GCSDSDMEDTDSAPGSRLQNSAGVYSLHLQDQVLSSLGPS-----TQTPSLPRTATPKKE PPPAP-GQPKAPFTKDKPPGR----------------------------LDAHLTRDEQRARALQIPFPVEKIINLPVAD FSEMMSKEQFNEAQLTLIRDIRRRGKNKVAAQNCRKRKLENIVELEHDLSNLKDEKEKLLKEKGEHDRSLYQMKKQLTTL YLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKS------------------------------------------- ------------------------------------------------RQSGTKL------------------------- ------------------- >Chicken_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MNLIDILWRQDIDLGARREVFDFSQRQK EYELEKQKKLEK-ERQEQLQKEREKALLAQLVLDEETGEFVPAQPAQRVQSENAEPPISFSQSTDTSKPE-E-------- --------------ALSFDDCMQLLAEAFPFIDDNEASPAAFQSLVPDQID--SDPVFISAN-----QTQPPSSPGIVPL TDAEN--------------------------------------------------------------------------- -MQNIEQVWEELLSLPELQ-CLNIENDNLAEVSTITSPE-TKPAEMHNS----------YDYYNSLP----IMRKDV-NC GPDFLENIEGPFSSILQPDDSS---------QLNV--NSLNNSLTLSSDFCEDFYTNFICAKGDGD--TGTTNTISQSLA DILSEP--------IDLSDFPLWRAFNDDHSGTVPECNDSDSGISLNANS------------SIASPEHSVESS-TCGDK TF------------------GCSDSEMEDMDSSPGSVPQGNASVYSSRFPDQVLPSVEPG-----TQTPSLQRMNTPKKD PPAGP-GHPKAPFTKDKPSGR----------------------------LEAHLTRDEQRAKALQIPFPVEKIINLPVDD FNEMMSKEQFSEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLSHLKDEREKLLKEKGENDKSLRQMKKQLTTL YIEVFSMLRDEDGKSYSPSEYSLQQTRDGNIFLVPKS------------------------------------------- ------------------------------------------------RKAETKL------------------------- ------------------- >ANOLE_LIZARD_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------QDMNLIDILWRQDIDLGARREVFDFSQRKK ASELEKQKKLER-ERQEQLQKEQEKAFLAQLQLDEETGEFVPIQPTQAIESGNTAISNNYSQNVHISKQDADN------- ------------LFSDVFDDCMQVLAETFLFVEDPKVSPVEFQQVAPSDIE--SNQVFVDPN-----HMQPLDSSVLQPA ISEFAMTPG----------------------------------------------------------------------E STQDMEQVWEELLSIPELQ-CLNIQNDNLAEVTPNTCTA-NTMSEAAID----------FTFYNPLP----PMENEVSTC SPEFLKPLEASYSGILLPD------------------LSQNNTSSTSSDFCEDFYPDFIDVKANNSITSPPPNFVDQALT GFLNEP--------IDLSDFAQCKAFNCDLAGNPQECTDSDSGISLNRSP------------STTSPAHSIDSSSICRDT GF------------------GCSDTEIEEMDSAPGSVQQSNTQMPVFQF----LLPLSPPVEQRSPTAAS-PVKGEVKRE LPANP-GHSEAPFMKDKSYSQ----------------------------DEAHLTRDELRAKALQIPFPVEKIINLPVDD FNEMMSKEQFTEAQVTLIRDIRRRGKNKVAAQNCRKRKLENITELEYDLGYLKDEREKLLKEKAENDKSLHLLKKQLSTL YLEVFGMLRDEDGKPYSVNEYSLQQTRDGGIFLVPKT------------------------------------------- ------------------------------------------------KKPGTK-------------------------- ------------------- >FROG_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MMEIEMPLPLQSQQDMDLIDILWKQDIDLGVSREVFDYNQRQK ENELEKQKKLEK-ERQEQLQKEREKALYAQLQLDEETGEFIPIQQAAPIETAAVTQELASSIEVKPSLVH---------- --------------DLSFDECLKILGETFQLGPANEESSLAYQTLEPSDPIE-TNQTFLQSE------PNPVPAGTLSSI PAEGEIM------------------------------------------------------------------------- --HEMNQAWEELLSIPELQ-CLNNEIENMVDLSMYTNQESITMTETPDT----------YSFLSPLS----TIEKP-HES STVFSSDLVDTFTSSLP---------------------SVNTNTAFN---VESFCDDIFTLDPKVTNVVPLTDNSGQLLN ELLNDN--------VDITDLSLCKAFNGN---NQPEFNDSDSGVSVNASP------------CATSPSQSMSGS-VYGEP HH------------------SYSDSDMEDMDSTPETAQQKPPDNFTAAFTEDTYFTLSPFVSHDTDPFDI-EAHTPSAKE IPASP-GYSKAPFAKDKYLSR----------------------------QEARFTRDEQRAKVLNIPFSVDKIVNLPVDN FNELMSKYQFNEAQLALIRDIRRRGKNKVAAQNCRKRKMDNIVELETDLDKLKYEKEKLLAERGEYNNSLSQLKKKLGAL YMEVFNKLQDENGQPYSPHEYSLQQTKEGNIFLVPKT------------------------------------------- ------------------------------------------------KKVSIKKE------------------------ ------------------- >FUGU_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------MTMEMDVMHSIQ-QDMNLIDILWKQDIDLGASREVFDYNHRQK EHELQRQLEQQE-EKRLHLLREQEKALLAQLQLDEETGEYVP-RPVALPPLQSAVIPLEVSQVT--VSHSGD-------- --------------AMSFDECLQLLAETFP-VGETENSSVGLNTTEV-RPMLSPELAAVPS--------PTLSPDPLSA- -SPSQAMC------------------------------------------------------------------------ --PELEEAWMELLSLPELQPCLNIKMEDAVETAAYPLPP---SPDAQNP---------NCQFYQTN--SAEVETNAINIC PVEFLNTVEASVPSMVQSDHLT---------QAD--SPQFHTDFAAESFG-EMFYSNPVQKENTGQH--GLDGYNSDAMS DMASQP-FTP----AGLYSLSPGDAFD--KHDLMAELPDSDSGISSHTSP------------NASSPG---KSV--YGDG SF------------------HHSDSDMEEMDHNPGSAETDFSEMFSINFEPDDLQRTLSVSA-LERSEEQMEGKLEPHKM DSVEECGQSGAPFTKDK-KRR----------------------------SDARLSRDEQRAKALKIPLSVSRIINLPVDD FKELLSKHHLNDAQMALVQDIRRRGKNKVAAQNCRKRKMENIVGLEGELDSLKEEKERLLSEKVQKAAHLKEMKQQLNSL YLEVFSKLRDEKGNSYSPSEYSLQQSTNGSIFLVPRV------------------------------------------- ------------------------------------------------KKTLAKSD------------------------ ------------------- >MEDAKA_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------FCLRLFFQDLDLIDILWKQDIDLGARREVFDYNHRQK EHELQRQRQLEE-EKKLHLLREQEKALLAQLKLDEETGEYIP-HTKPILPPQQAVVSIEISQDANFTEETGD-------- --------------GMSFDECLQLLAETFP-VGETEVYKCMFAAQNPSVCMELPPVSVYPSGTMMPSEQPALSPAVLPNP LTPPQRVT------------------------------------------------------------------------ --PDLEEAWMEILSLPELQ-CFKMQVDETMEATNFPIQT---SPQVQNPSYPNNQLFPNTPYYPMPS-ASDLKTKNLNVG PGEFMNTCDGPVPSMAPSD-IS---------QINVEDPQVNPNFTPDSFCSSVFYPDTIVEESSSQH--GHEES--ENVS EIPSKPSFTP----MDLYTLSPEDVFDR-SKRLPADFPDSDSGISTHSSP------------YSSSPS---KSA--YGGG SY------------------NFSDSEMDDLDHNPGSAESDYSEMFSLNFQPEDLELAKPESE-QTGQCKQLDKKPKQHME DPAEESGHSGTPFTKDKPKKR----------------------------SDVRLSRDEQRAKALKIPFTVSMIINLPVDD FNEMMSKHELNEAQLALVRDIRRRGKNKVAAQNCRKRKMENIVGLEHELDLLKEEKERLLDEKSKNATNLKEMKRQLNSL YLEVFGKLRDEKGNSYSPSEYSLQQSTDGSIFLVPRM------------------------------------------- ------------------------------------------------KKTYIKPH------------------------ ------------------- >STICKLEBACK_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------MIEMEVMHSGH-QDMELIDILWKQDIDLGARREVFDYNHRQK EHELRRQRELEE-EKRQHLVREREKALLAQLQLDEETGEYIP-RPPAG-------APLEDTQNVNFPGETDD-------- --------------AMSFDECLQLLADTFP-VEETETASVCLDTAAVSAPMMSPEQPGLPP--------AALSTGPPLA- -TPPERMS------------------------------------------------------------------------ --PDLEQAWMELLSLPELQQCLSMQMEDTLETTTYPLSN---SPEVQNP---------NYPFYPMN--ATDRLTNPLNVS PAQFMNTFDGSLPSLVSPDSLH---------QVKENSPQLNAKFNAEIFC-DMFYPNDVLDESGG-----LEGNGSNAMP DISNKPPFTP----VDLYSLSPDDAFDREKTNLTAERPDSDSGISSNTSP------------NASSPG---KSS--HGDE SF------------------GFSDSDMEEMDDNPGSVESDYSDMFSLNFQPDHLHQAISLSARIGQPQQQQEKNPKEHKT DPDEESGHNSSPFAKDKQKKR----------------------------SEKRLSRDEQRAKALKIPFTVDMIINLPVDD FNEMMSKHQLNEAQLALVRDIRRRGKNKVAAQNCRKRKMENIVGLESNLDSLKEEKERLLGEKSQNATSLKEMKKQLNSL YLEVFSTLRDEKGSSYSPSDYSLQQSTDGSVFLVPRV------------------------------------------- ------------------------------------------------KKTFLKSEDNLLSPL----------------- ------------------- >TETRAODON_NFE2L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------LLPVDFCASVIISEQDMNLIDILWKQDIDLGASREVFDYNHRQK EHELQRQLELQE-EKRLHLLQEQEKALLAQLQLDEETGEYVP-RPAPVPALQSAIMPLEVSQDVGFPADSSD-------- --------------AMSFDECLQLLAETFP-VEETENTSVSLNASEV-APMASPELSVVPS--------TTQSPGSLSG- -SSMPAMY------------------------------------------------------------------------ --PELEEAWMELLSLPELQPCLNIKMEDAVETTAYPLPN---SPAGQQP---------KGPFYPPN--CSKVETNNINVC PAEFMNTVEGSVPRMVQSDHLN---------QAH--NPAFGADFAAKNFD-EMFYPNPILEESTGQR--GLDGSNSDAMS DMASQP-FTP----ADLYSLSPGDALD--QHELMAELPDSDSGISSHTSP------------NASSPG---KSL--YGDG SF------------------HHSDSDMDEMDQNPGSAETDFSEMFTINFQPDDLQPTPSESA-LQRSEQQMEGKLERHEM DSVEECGPRCSPFTKDK-KRR----------------------------TDARLSRDEQRAKALKIPLSVSMIINLPVDD FKELLSKHHLNDAQMALVQDIRRRGKNKVAAQNCRKRKMENIVGLEGELDSLKEEKERLLSEKVQRAAQLKQMKQQLSSL YLEVFSKLRDDKGNSYSPSEYSLQQSTNGSIFLVPRV------------------------------------------- ------------------------------------------------KKTFAKSD------------------------ ------------------- >Human_NFE2L3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MKLPKPWWAGGG-LLQLTILLSLVGLRVDLDLFLPPPA AALW------------EELLPLCPTRPASASNPFSASEGWERTPLLPAK-----------GRLLHEVRALGVPFIPRTRV DAWLVHSVATGNADGA------------HGLLGTAA--SSAVGDGG------QSASAGGGDPRAAHSSPLAAE------- ------------EEEE-KAAEPTAQVPDAGGCGSQENGMLREKSEAVDHSSQQEENEEGVSAQ---AKSRQQSKTEEHKM ACASAREAE-----------------------------------------------------------KITEARNESHLH WSDTSFSLEDLFQLLSS-QPEHSLEG-----ISVEDIPPFLSSVCESVN-----------SSAQN-INLSQAISHDVNLH EAMLLYPNNTFRRDPSARSSQA--------QEPFLQLNP-HTNPEQATPAMSL----PPFDNQMRNLTS-------QDLL YDLDSNIFDG----INLMSLATG--FSPLEVSQLFEEP--DSGLSLNSSY------------NSTSLTN---SYRIYDG- -----------------TVGYNSDLQSLCHD--LGAVGGCYPEPHKHCH-MDHRTIAGFHVSLECQQVFHDHTYHLQSGA SEPTSES--FAWSEKSQKTS------------------------GCLDNPDRNLSRDEQRAKALHIPFSVDEIVRMPVDS FNSMLSRYYLTDLQVSLIRDIRRRGKNKVAAQNCRKRKLDIILNLEDDICNLQAKKEALKNEQTQCSKAIDIMRQKLHGL HQDVFNRLRDDQGRPVNPSQYALQYSHDGTVLIVPKE------------------------------------------- ------------------------------------------------LISSGHKKEAPKGKRERRN------------- ------------------- >Mouse_NFE2L3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MKLPKPWWAGGG-LLQLTILLSLVGLRVDLDLFLPPPA AALW------------EELLPLCPTRPASASNPFSASEGWERTPLLPAK-----------GRLLHEVRALGVPFIPRTRV DAWLVHSVATGNADGA------------HGLLGTAA--SSAVGDGG------QSASAGGGDPRAAHSSPLAAE------- ------------EEEE-KAAEPTAQVPDAGGCGSQENGMLREKSEAVDHSSQQEENEEGVSAQ---AKSRQQSKTEEHKM ACASAREAE-----------------------------------------------------------KITEARNESHLH WSDTSFSLEDLFQLLSS-QPEHSLEG-----ISVEDIPPFLSSVCESVN-----------SSAQN-INLSQAISHDVNLH EAMLLYPNNTFRRDPSARSSQA--------QEPFLQLNP-HTNPEQATPAMSL----PPFDNQMRNLTS-------QDLL YDLDSNIFDG----INLMSLATG--FSPLEVSQLFEEP--DSGLSLNSSY------------NSTSLTN---SYRIYDG- -----------------TVGYNSDLQSLCHD--LGAVGGCYPEPHKHCH-MDHRTIAGFHVSLECQQVFHDHTYHLQSGA SEPTSES--FAWSEKSQKTS------------------------GCLDNPDRNLSRDEQRAKALHIPFSVDEIVRMPVDS FNSMLSRYYLTDLQVSLIRDIRRRGKNKVAAQNCRKRKLDIILNLEDDICNLQAKKEALKNEQTQCSKAIDIMRQKLHGL HQDVFNRLRDDQGRPVNPSQYALQYSHDGTVLIVPKE------------------------------------------- ------------------------------------------------LISSGHKKEAPKGKRERRN------------- ------------------- >Rat_NFE2L3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------MRAGFNCGALPGNGAGPESWELQVSSLPIWVPGSSRHCVGSRGSAFV PGWGEAATAPCTPWSFVFPAGATRAAVGPGRVDTGISGAPWEMKLPKPWWASGG-LLHLRLLLSLVGLRVDLDLCLLPPV AALW------------EELLPFFPTRPASASNPFSASEGWGRTPLLPAK-----------GRLLHEVRALGVPFIPRTLV DAWLVHSVATGDADGT------------HGLLGTAA--SSAVGDGG------QSASAGGGDPGEAHSSPLAAE------- ------------EEEEEKAAEPTAQVPDAGGRGSQETEVLSEKSEAVDHSSQQKENEEGVSAQ---ATSRQQRKREENKM TGASAWEAE-----------------------------------------------------------KIVEARNESHLH WSDTSFSLEDLFQLLSS-QPEHSLEG-----ISVEDIPPFLSSVCESVN-----------PSVHN-INLNQAISHDVNLH EAMLLCSNTSIR-DPSARPSQA--------QEPFLQLNS-PTSPQQAIPAMSL----PLANNQMRNLTS-------QDLL YDLDSNIFDG----LNLMSLATG--FSPLEVSQLFEEP--DSGVSLNSSY------------NSTSLTN---SNCTFDG- -----------------TN--------------LGAVGGCYPEPRKHCH-VDHRTISGFHGALECHQVFHDHTYHLQSGV PEATSET--FTWTGKSQKIS------------------------GCLDDPDRNLSRDEERAKAMHIPFSVDEIVHMPVDS FNSMLSRYYLTDSQVSLIRDIRRRGKNKVAAQNCRKRKLDIILNLEDDICNLQAKKEALKSEQTQWNKAINTMRQKLYDL YHNVLNRLRDDQGRPVNPSHYALQYSHDGTILIVPKE------------------------------------------- ------------------------------------------------LVSSGHKKEVPKVKRERN-------------- ------------------- >Cow_NFE2L3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------MKYLKPWWSDGGSLFHLTILLSLAELRLDLDLDLDLDL YLLFPPRT----LLGDELLLRNGQTSHISALSPFPASGGWGRAELLHPKCWERDPAAPPEGRLLREVRALGVPFIPSIRV DAWLVHSVATGDADGA------------HALLGAAA-ASSAGGVGAGVEGVSQAAPGGGGGPRAVQSSPLAAG------- ------------EEEEKAPAERTAQVSDADGHASEENEVLRG----VSHSPQHEENEQRSSTQ--KEKSLQQKNEDENKV ADKPAWEAE-----------------------------------------------------------KTTESRSERYQN GTDAFFSLEDLFQLLSS-QPENLLEG-----VSLGDIAPLPRSINDGMN-----------SPTHYNVNFSEAVSHDVSLH EAMLRCSDNTFRRDPVARTSQP--------QEQILQLSS-ITNTEQTLPGTNLTGFLPFVDNQMRNLS--------QDHL YDLDINILDE----TNLMSLATG--FDPMEVSWLLEEPGYDSGLSLDSSN------------NSTSVIKSNSSHSICEG- -----------------ATGSSSD---LSHHDLEGAVGGYCPEPSKLCY-MNDKSDSHFHGDLVFQHVSHNHTYHLEPSA LESTSES--FSMPGKSQKIS------------------------RYLNDTDRNLSRDEQRAKALHIPFSVDEIIRMPVDS FNSMLSRHYLTDLQVSLIRDIRRRGKNKVAAQNCRKRKLDVILNLEDDVCSLQAKKETLKREQSQCHKAINIMKQKLHHL YCDVFSRLRDDQGRPVSPNQYALQCTHDGSVVIVPKE------------------------------------------- ------------------------------------------------LIIPGQKKENQKGKRKNERKN----------- ------------------- >Dog_NFE2L3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------MLVSCHMSFYIGLTHNI AALS-----------KKERIRDAERSATYALSPFAASAGWGRADQLHPKGREPE----PEGRLLREVRALGVPFIPRTRV DAWLVHSVAAADADGA------------HGLLGATASAASAGGVGAGVEDSSQAAPGDGD-PRAAASSPVAAG------- ------------EEE-RAPAGPTAQVLDAGGRANQGSEVLREKHEAVDHSSQNEENEQRVSSA--QERS--QKNE-ESKI ANNPDWEAE-----------------------------------------------------------KPTESSNERALN GTDTAFSLEDLFQMFSS-QPENSLEG-----ISLEDT--FPGNINDGVN-----------SSIHHNVNFSQAISQDVNLH EAMLLCPDNTFRREPVARTSQ----------EPFLHLNSQNTNSEQNLPGTNLTGFFPLVGNQMRNLTS-------QDLL YDLDLNIFDE----INLMSLATG--FDPMEVAQLFEEPDSDSGLSLNSSH------------NSTSVTKSNSSHSVCEG- -----------------ATGSSSDLESLSHHDLEGAVGGYYAEPSKLCH-MDHRSNSGFHGDLTFQHVFHNHTYHLQPSA LESTSTS--LSRHGKSQKSR------------------------RYLNDTDRNLSRDERRAKALHIPFSVDEIVRMPVDS FNNNLSRHYLTDLQVSLIRDIRRRGKNKVAAQNCRKRKLDIILNLEDDVCNLQAKREILKRERARYNKAINTMKQKLHEL YHDIFSRLRDDEGRPVNPNQYVLQCSQDGSVLIVPKE------------------------------------------- ------------------------------------------------LVTSGHKKENHKGKRK---------------- ------------------- >Horse_NFE2L3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MTAPNVEAQIHT YSLE-----------NPGAVAPNKEQHLWALELDLFVHPVPPSSVPTAS----------EGQLLREVRALGVPFIPRTRV DAWLVHRVAAGDADGA------------HGLLGAAA-ASSAGGVGAGVDGGSQAAPGGGGDPRASPSSPLAAR------- ------------QEE-KAPAEQTARVPDADGRASEENEVLRERHEAVDHSSQHEENEQRVSAQ--EEKSLQQKNEDENKT ADKPDWEAE-----------------------------------------------------------KTTESRNERHLN GTDTSFSMEDLFQLLSSSQPENSVEG-----ISLGDIPALPGSSNDGMN-----------SSAHYNVNFSQAISHDVNLH EAMLLCPDNTFRRDPVVRTSQP--------QEPFLQLNSHTTNAEQSLPVANLTAFLPFVDNQMRNLTS-------EDFL HDLNINIFDE----INLMSLATGD-LDAMEVSQLFQEPDSDSGLSLNSSH------------NSTSITKSNTSHSICEEG -----------------ATGYSSDPESLPHHNLEGAVGGNYPAP------MGHRSDSGFCGDLAFQHVFHNHTYHLEPRA LESNSES--FSWPEKPEKMS------------------------RYLSDTERNLSRDERRAKALRIPFSVDEIVRMPVDS FNSMLSRHYLTDLQVSLIRDIRRRGKNKVAAQNCRRRKMDIILNLEEDVCNLQAKKETLKRERAQCNKAINIMKQKLHHL YHDVFSRLRDDEGRPVNPNQYALQYSHDGSVLIVPKE------------------------------------------- ------------------------------------------------LVTSGHKKENRKRKREGIEDGFH--------- ------------------- >Opossum_NFE2L3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLNSQL PPLR-----------EIILGPSSAYTQTQFHNLRNTLDGYGIHPKSVDLDYYFT-----ARRLLNQVRALDRFQVPTTEV NAWLVHRDPEGSVSGS-QPSSALALESASGLQDVTGSESG------VRESEAEQGFGEELEDLGAVAPP----------- -----------------VSGELTKEDIDLIDILWRQDIDLGAGREIFDYSHRQKESEVDKEL-----RDGGECGDSWPNE GTEALAGN--LLVDGETGESFPAQFP------------------------------TADVSSITEAVPSESESSAIQNNL LSPLLTETESPFDLEQQWQDLMSIMEMQAMEVN-TATNEILYSATTGDA----------LSTNYSLAP-NTPINQNVSLH QASLGSCAQDF-SLFSPEIE---SLPVANGSTLLQLAPNNSTSLNSTFGSTNLTGIFFPPQLN-STANETANPELPDPLG GLLDEAMLDE----ISLMDLAIEEGFNPVQASQLEEEFDSDSGLSLDSSH-------SP---ASLSSSEGSSSASSS--- ----ASSSASSSFSEEGAVGYSSDSENLDLEEPEGAVG-YQPEYTKFCR-MSYQDPSQLSYLPFLEHVGHNHTYNMAPGA LDTSEPQLNGVLKKGSREKQA--------------------------DFLDKQMSRDEHRARAMKIPFTNDKIINLPVEE FNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKSKLLREKVEFLKSLRQMKQKVQSL YQEVFGRLRDENGQPYSPTQYALQYAGDGSVILIPRT------------------------------------------- ------------------------------------------------MAD-QQARRQEKKQKDRRK------------- ------------------- >Platypus_NFE2L3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------MRPPK YNIR--------------------KAQRASSGRMETSG--PPPPVFPRR-----------SSTGLQVRVSAVPLSGLEGC GLALLRGRVAEDDD--------------LPILVASS-------------------------PCPDQRS--TED------- ------------KKRWVWSARPLADVAVAN---------------TVCHS------------------------------ -VVPVAVAS-----------------------------------------------------------ALSTSRNE---- -ADGTLSLEDMFQLFSS-QTENAPKG-----ISLGDVQPATSESRGGSS-----------SSRHS-VNFTQAISHDVSLH EATLLSSD-ASRRNSGSENCRS--------QETFLPFNSSSTNSSQSPSASNLTALFPFVDTSVGNATS-------QDLL PGLDDNIFDE----INLMSLALEEGFNPLAVSRLFEEPDSDSGLSLNSSR------------SSASASNSDSSALACNGE G----------------AVGYGSDVGSPRHDGLEGAVGSDWPESGRLRRPGDYLGDPETPGKPTFRHVLHNHTYHLLPDP ALSTPESP-DSWPGTSPQVRD-----------------------RDLRDLER