>Homo_sapiens_UNC5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MAVRPGLWPALLGIVLAAWLR-GSGAQQSATVAN----PVPGAN------PDLLPHFLVEPEDVYIVKNKPV LLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLP----------------------------------------- ---------------------------TMEVRINVSRQQVEKVFG--LEEYWCQCVAWSS--SGTTKSQK---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYIRIAYLRKN--------------- ---FEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH----------------------- ------------------------------------------------------------------SLVVRQARLADTAN YTCVAKNIVARRRSASA------------------AVIVY--------------------------------------V- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------DGSWSPWSKWSACGLDCTH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECSDPAPRNGGE---ECQGTDLDTRNCTSDLCVHTA----------------------------SG PEDVALYVG----LIAVAVCLVLLLLVLILVYCRKKEGL----------------------------------------- ----------DSDVADSS----ILTSG-FQPVSIKPSKADNP-------------------------------HLLTIQP DLSTTTTTYQGSLCPRQ-----DGPSPKFQLTNGHLLS------------------------------------------ -------------------------------------------------------------------------------- -PLGGGRHTLHHSSPTS-----------EAEEFVSR-------------------------------------------- --LSTQN-------YFRSLPRGTSNMTYGTFN-----FLG-----------------GRLMIPNT--------------- ---------------------------------------------------------------------------GISLL IPPDAIPRGKIYEIYLTLHKPEDV-------------------------------------------------------- ---------------------------------------RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPD --SWSLRLKKQS------------------CEGSWE-------------------------------------------- -------------------------------DVLHLGEEA------------PSHLYYCQLEASACYVFTEQLGR-FALV GEA---LSVA-AAKRLKLLLFAP-VACTSLEYNIRVY---------------CLHDTHDALKE-VVQLEKQLG------- ------------------------------------------------------------------------------GQ LIQEPR---VLHFKDSYHNLRLSIHDVPSSLWKSKLLVSY-QEIPFYHIWNG-TQRYLHCTFTLERVSPSTSDLA----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKLWVWQVEGDGQSFSINFNITK --------------------------------DTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRG-- -ADWRTLAQKLHLD----SHLSFFASKPS----PTAMILNLWEARHFPN---------GNLSQLAAAVAGLGQPDAGLFT -----------VSEAEC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Macaca_mulatta_UNC5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------TGAQQSATVAN----PVPGAN------PDLLPHFLVEPEDVYIVKNKPV LLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLP----------------------------------------- ---------------------------TMEVRINVSRQQVEKVFG--LEEYWCQCVAWSS--SGTTKSQK---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYIRIAYLRKN--------------- ---FEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH----------------------- ------------------------------------------------------------------SLVVRQARLADTAN YTCVAKNIVARRRSASA------------------AVIVY--------------------------------------V- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------DGSWSPWSKWSACGLDCTH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECSDPAPRNGGE---ECQGADLDTRNCTTDLCVHTA----------------------------SG PEDVALYVG----LIAVAVCLVLLLLVLILVYCRKKEGL----------------------------------------- ----------DSDVADSS----ILTSG-FQPVSIKPSKADNP-------------------------------HLLTIQP DLSTTTTTYQGSLCPRQ-----DGPSPKFQLTNGHLLS------------------------------------------ -------------------------------------------------------------------------------- -PLGGGRHTLHHSSPTS-----------EAEEFVSR-------------------------------------------- --LSTQN-------YFRSLPRGTSNMTYGTFN-----FLG-----------------GRLMIPNT--------------- ---------------------------------------------------------------------------GISLL IPPDAIPRGKIYEIYLTLHKPEDV-------------------------------------------------------- ---------------------------------------RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPD --SWSLRLKKQS------------------CEGSWE-------------------------------------------- -------------------------------DVLHLGEEA------------PSHLYYCQLEASACYVFTEQLGR-FALV GEA---LSVA-AAKRLKLLLFAP-VACTSLEYNIRVY---------------CLHDTHDALKE-VVQLEKQLG------- ------------------------------------------------------------------------------GQ LIQEPR---VLHFKDSYHNLRLSIHDVPSSLWQSKLLVSY-QEIPFYHIWNG-TQQYLHCTFTLERVSPSTSDLA----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKLWVWQVEGDGQSFNINFNITK --------------------------------DTRFAELLALESEGGVPALVGPSAFKIPFLIRQKIISSLDPPCNRG-- -ADWRTLAQKLHLD----SHLSFFASKPS----PTAMILNLWEARHFPN---------GNLSQLAAAVAGLGQPDAGLFT -----------VSEAEC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Mus_musculus_UNC5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MAVRPGLWPALLGIVLTAWLR-GSGAQQSATVAN----PVPGAN------PDLLPHFLVEPEDVYIVKNKPV LLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLP----------------------------------------- ---------------------------TMEVRINVSRQQVEKVFG--LEEYWCQCVAWSS--SGTTKSQK---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYIRIAYLRKN--------------- ---FEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH----------------------- ------------------------------------------------------------------SLVVRQARLADTAN YTCVAKNIVARRRSASA------------------AVIVY--------------------------------------VN GGWST-WTEWSVCSAS---------------CGRGWQKRSRSCTNPAPLNGGAFCEGQNVQKTACATLCP---------- -------------------------------------------------------------------------------- ------------------------------VDGSWSPWSKWSACGLDCTH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECSDPAPRNGGE---ECRGADLDTRNCTSDLCLHTS----------------------------SG PEDVALYIG----LVAVAVCLILLLLVLVLIYCRKKEGL----------------------------------------- ----------DSDVADSS----ILTSG-FQPVSIKPSKADNP-------------------------------HLLTIQP DLSTTTTTYQGSLCPRQ-----DGPSPKFQLSNGHLLS------------------------------------------ -------------------------------------------------------------------------------- -PLGSGRHTLHHSSPTS-----------EAEDFVSR-------------------------------------------- --LSTQN-------YFRSLPRGTSNMAYGTFN-----FLG-----------------GRLMIPNT--------------- ---------------------------------------------------------------------------GISLL IPPDAIPRGKIYEIYLTLHKPEDV-------------------------------------------------------- ---------------------------------------RLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPD --SWSLRLKKQS------------------CEGSWE-------------------------------------------- -------------------------------DVLHLGEES------------PSHLYYCQLEAGACYVFTEQLGR-FALV GEA---LSVA-ATKRLRLLLFAP-VACTSLEYNIRVY---------------CLHDTHDALKE-VVQLEKQLG------- ------------------------------------------------------------------------------GQ LIQEPR---VLHFKDSYHNLRLSIHDVPSSLWKSKLLVSY-QEIPFYHIWNG-TQQYLHCTFTLERVNASTSDLA----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKVWVWQVEGDGQSFNINFNITK --------------------------------DTRFAEMLALESEGGVPALVGPSAFKIPFLIRQKIITSLDPPCSRG-- -ADWRTLAQKLHLD----SHLSFFASKPS----PTAMILNLWEARHFPN---------GNLGQLAAAVAGLGQPDAGLFT -----------VSEAEC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Gallus_gallus_UNC5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------GGDSCRTWSRWCPWRWLSSHVPTGAQQSVTVAS----PASGAS------PDLLPHFLLEPDDVYIVKNKAV SLACRATPATQIYFKCNGEWVHQGDHITQRSTDRGTGLP----------------------------------------- ---------------------------VMEVRIEITRQQVEKLFG--LEEYWCQCVAWSS--SGTTKSQK---------- -------------------------------------------------------------------------------- ------------------------------------------------------AFVRIAYLRKN--------------- ---FEQEPTAREVSIEQGVVLPCRPPEGIPPAEVEWLRNEELVDPALDANVLVTPEH----------------------- ------------------------------------------------------------------SLVLRQARLADTAN YTCVAKNIVARRRSASA------------------AITVY--------------------------------------VN GGWST-WTQWSGCSTS---------------CGRGWQKRSRTCTNPTPLNGGAFCEGQNVQKSACTTLCP---------- -------------------------------------------------------------------------------- ------------------------------VDGDWSEWSKWSVCGAECTH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECSEPAPRNGGQ---ECHGPELETHNCTSELCSPMCPRG----AD------------NLPHAATPG AEDLALYVG----LIAVAVCLVLLLLVGVLVYCRKKGGL----------------------------------------- ----------DADVADSS----ILTTG-FQPVSIKPSKADN---------------------------------LLTIQP DLSTATMTYQGSLCPRQ-----DG-PAKLQLPNGHLLS------------------------------------------ -------------------------------------------------------------------------------- -PLGAGRHTLHHSSPAA-----------EGADFVAR-------------------------------------------- --LSTQS-------YFRSLPRGTANMAYGTFN-----FLG-----------------GRLMIPNT--------------- ---------------------------------------------------------------------------GVSLL IPPDAIPRGKIYEVYLTLHKHEEV-------------------------------------------------------- ---------------------------------------RLPLAGCQTLLSPIVSCGPPGVLLTRPAILAMGHCVEAGAE --HWSLRLKKQS------------------CEGTWE-------------------------------------------- -------------------------------DVLQLGAEP------------RTELYYCQLEAQACYIFTEQLGR-FALV GES---LSMA-ASKRLKLVLFAP-TACPSLEYNIRVY---------------CLSDTQDALKE-VMQLEKQMG------- ------------------------------------------------------------------------------GQ LIGAPR---VLHFKDSYHNLRLSIHDMPSSLWKSKLLASY-QEIPFYHIWSG-LQPYLHCTFTLERLSPSTCELA----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKIWIWQVEGDGQSFTINCNIAK --------------------------------DTRFSDWLVPDSEVGSPALVGPSAFKIPFLIRQKIISSLDTPCARG-- -ADWRTLAQKLNLD----SHVSFYASKPS----PTAMILNLWEARHFPN---------GNLSQLAAAVAEVGKQDSALFA -----------VSEAEC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Taeniopygia_guttata_UNC5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------TGAQQSATVAN----PASGAS------SDLLPHFQLEPEDVYIVKNKAV SLACRATPATQIYFKCNGEWVHQGDHVTQHSTDRGTGLP----------------------------------------- ---------------------------VMEVRIEVTRQQVEKIFG--LEEYWCQCVAWSS--SGTTKSQK---------- -------------------------------------------------------------------------------- ------------------------------------------------------AFVRIAYLRKN--------------- ---FEQEPTAREVSIEQGIVLPCRPPEGIPPAEVEWLRNEELVDPELDANVYVTPEH----------------------- ------------------------------------------------------------------SLVLRQARLADTAN YTCVAKNIVARRRSASA------------------AIIVY--------------------------------------VN GGWST-WTQWSGCSTS---------------CGRGWQKRSRTCTNPTPLNGGAFCEGQNVQKTACTTLCP---------- -------------------------------------------------------------------------------- ------------------------------VDGAWSEWSKWSECGAECTH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECSEPAPRNGGR---DCHGPELDTRNCTSELCT----------------------------HAAPG AEDVALYVG----LVAVAVCLVLLLLVGVLVYCRKKGGL----------------------------------------- ----------DADVADSS----ILTAG-FQPVSIKPSKADNP-------------------------------SLLTIQP DLSTTTMTYQGSLCPRQ-----DG-PAKLQLPNGHLLS------------------------------------------ -------------------------------------------------------------------------------- -PLGAGRHTLHHSSPAA-----------EGADFVAR-------------------------------------------- --LSTQS-------YFRSLPRGTNNMAYGTFN-----FLG-----------------GRLMIPNT--------------- ---------------------------------------------------------------------------GISLL IPPDAIPRGKIYEVYLTLHKQEEV-------------------------------------------------------- ---------------------------------------RLPLAGCQTLLSPIVSCGPPGVLLTRPAILAMGHCVEASAE --NWSIRLKKQS------------------CEGTWE-------------------------------------------- -------------------------------DVLQLGAEP------------CTELYYCQLEAQACYVFTEQLGR-FALV GES---LSMA-ASKRLKLVLFAP-AACPSLEYNIRVY---------------CLRDPQDVLKE-VIQLEKQLG------- ------------------------------------------------------------------------------GQ LIGAPR---VLHFKDSYHNLRLSIHDMPSSLWKSKLLASY-QEIPFYHIWSG-LQPFLHCTFTLERLSTSTCELA----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKIWVWQVEGDGQSFTVNFNIAK --------------------------------DTRFSDWLVPD-EVGTPALVGP-AFKIPFLIRQKIISSLDPPGTRG-- -ADWRTLAQKLNLD----SHLSIFASKPS----HTAMILNLWEARHFPN---------GNLSQLAAAVAEVGKQDGALF- ------------SEAEC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Danio_rerio_UNC5A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------SGLP----------------------------------------- ---------------------------VMQVKIDISRQQVEKIFG--LEDYWCQCVAWST--TGTQKSQK---------- -------------------------------------------------------------------------------- ------------------------------------------------------AFVRIAYLRKN--------------- ---FEEEPLGKEVALDQELLLRCHPPEGVPPAEVEWQRNEELIDPKTDPNFFITTDH----------------------- ------------------------------------------------------------------NLIIKQTRLADTGN YTCVAKNIVARRKSSSA------------------TVIVY--------------------------------------VN GGWST-WATWSSCSAV---------------CGRGWQKRSRSCTNPTPLNGGTSCEGQSLQKSACTATCP---------- -------------------------------------------------------------------------------- ------------------------------VDGGWSEWSKWSPCGADCSM------------------------------ -------------------------------------------------------------------------------- ----------WRSRECTQPTPGTGGK---DCQGLDLQSLNCTSEQCPQTAS----------------------------G AEDVALYVG----MVTVALCLALLLVVLVLVYRRKKEGL----------------------------------------- ----------DADVADSS----ILTTG-FQPMGIKPSKPENS-------------------------------HLLTIQP DLTTSTSSYQGSLRSRH-----EV-SSKFSMSNGPLLD------------------------------------------ -------------------------------------------------------------------------------- -PLPNGSHTLHNGKLSS-----------DADDFMSR-------------------------------------------- --LSSQT-------YLKTLPRENGNTSYGTFNFLG----------------------GRLTLPNT--------------- ---------------------------------------------------------------------------GISLL IPPEAIPRGKIYEIYLTIQKKEDMS------------------------------------------------------- ---------------------------------------RLPLAGCQTLLSPVVSCGPPGVMLTRPVILCMDHCSDACLE --NWAIRLKKQS------------------YEGTWE-------------------------------------------- -------------------------------DVLLLGEDL------------LSEPYYCQLEAETCRVFTEQLGR-FALV GES---LSMA-AAKRLKLLLFAP-AYCSTLEYNIRVY---------------CTDDTQDLLKE-VMQMERQLG------- ------------------------------------------------------------------------------GR LIDEPH---VLLFKDSYHNLRLSIHDMPHTHWRSKLLAGY-QEIPFYHIWSG-SQRTLHCSFTLERQSLSTSDLS----- -------------------------------------------------------------------------------- ---------------------------------------------------------CTLCVWQVEGEGQSFSLDFNIAK --------------------------------DIRPLDSDFLLLENCSPALAGPSAFQIPYLIRQKICSSLDAPCPNG-- -ADWRLLAQRLKLD----RY------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Takifugu_rubripes_UNC5A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------GAEHAATATLPAAF------SDLLPHFQVEPEDEYIVKNKPV TLTCRSTPATQIYFKCNGEWVHQDDHLIERTVDPATALP----------------------------------------- ---------------------------IMQVTIDITRQQVEKIFG--LDQYWCQCVAWST--TGTQKSQK---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYIRIAYLRKN--------------- ---FEEEPQGKEVALDQEVLLRCHPPEGVPQPEVEWQRNEDILNPESDPNFFVTADH----------------------- ------------------------------------------------------------------NLIIRKARMADTGN YTCVAKNIVARRKSTSA------------------AVLVYGGAFALLIFFHVVSCQQVRIWHLRAFKPSPPAPALT--VN GGWST-WTTWSSCSAV---------------CGRGWQKRSRSCTNPTPLNGGSSCEGQNIQKSVCVATCP---------- -------------------------------------------------------------------------------- ------------------------------VDGGWSEWSKWSACGADCSM------------------------------ -------------------------------------------------------------------------------- ----------WRTRECTQPSPGTGGK---DCQGLDLQSLNCTSEQCPQSYG----------SRLTL-----LLSVAAVSG AEDVALYVG----VVAVALCLTLLLIVVVLVYRRKKEGL----------------------------------------- ----------DADVADSS----ILTTG-FQPMGIKPSKPENS-------------------------------HLLTIQP DLTTTTTSYQGTLRSRH-----DT-TGKFSMTNGTLLD------------------------------------------ -------------------------------------------------------------------------------- -PLPNGSHTLHNGKLNP-----------DPPEFVSR-------------------------------------------- --LSTQS-------YFKTLPRDVANASYGTFNFLG----------------------GRLTIPNT--------------- ---------------------------------------------------------------------------GISLL IPPEAIPRGKIYEIYLTVQRKEDL-------------------------------------------------------- ---------------------------------------RLPLAGCQTLLGPVVSCGPPGVVLSRPVILSMDHCSDGCLD --NWALRLKKQN------------------YEGVWE-------------------------------------------- -------------------------------DVLLMGEEL------------VSEPYYCQLEAETCRLFSEQLGT-FALV GES---LHMG-AAKRLRLVLFSD-AYCSTLEYNIRVY---------------CMDDTQEVFKE-VMQMERQLG------- ------------------------------------------------------------------------------GR LIDEPH---ILLFKDSYHNLRLSIHDMPQAHWRSKLLAGY-QEIPFYHIWNG-SQRYLHCTFTLERLSLSTCELT----- -------------------------------------------------------------------------------- ---------------------------------------------------------CQLCVWQVEGEGQSFSLDFNIAK VTARALASSHGV--------------------DTRAIDAEFMLMDSSASALAGPSAFQIPYLIRQKICSSLDAPCPNG-- -ADWRMLAQRLKLE----RHMSFFASKAS----PTSVILDLWEAQHFHS---------GNINQLAAVMADIGKQEAMIFL -----------VSDGEC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Tetraodon_nigroviridis_UNC5A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------LP----------------------------------------- ---------------------------VMQVTIDITRQQVEKIFG--LDQYWCQCVAWST--TGTQKSQK---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYIRIAYLRKN--------------- ---FEEEPQGKEVALDQEVLLRCHPPEGVPQAEVEWQRNEDILNPEMDPNFFITADH----------------------- ------------------------------------------------------------------NLIIRKARMADTGN YTCVAKNIVARRKSTSA------------------AVIVY--------------------------------------VN GGWST-WTTWSSCSAV---------------CGRGWQKRSRSCTNPTPLNGGSSCDGQNVQKSVCVATCP---------- -------------------------------------------------------------------------------- ------------------------------VDGGWSEWSKWSACGADCSM------------------------------ -------------------------------------------------------------------------------- ----------WRSRECTQPSPGTGGK---DCQGLDLQSLNCTSEQCPQTFQGF----LSAHHRRQR-----QCEVAAVSG AEDVALYVG----VVAVALCLTLLLIIVVLVYRRKKEGL----------------------------------------- ----------DADVADSS----ILTTG-FQPMGIKPSKPENS-------------------------------HLLTIQP DLTTTTTSYQGTLRSRH-----DT-TGKFAMTNGTLLD------------------------------------------ -------------------------------------------------------------------------------- -ALPNGSHTLHNGKLNS-----------DPSEFVSR-------------------------------------------- --LSTQS-------YFKTLPRDVANASYGTFNFLG----------------------GRLTIPNT--------------- ---------------------------------------------------------------------------GISLL IPPEAIPRGKIYEIYLTVQRREDL-------------------------------------------------------- ---------------------------------------RLPLAGCQTLLGPVVSCGPPGVVLSRSVILSMDHCSDGCLD --NWALRLKKQN------------------YEGVWE-------------------------------------------- -------------------------------DVLLMGEEL------------VSEPYYCQLEAETCRLFSEQLGT-FALV GES---LHMG-AAKRLRLVLFSD-AYCSTLEYNIRVY---------------CMDDTEEVFKE-VMQMERQLG------- ------------------------------------------------------------------------------GR LIDEPH---ILLFKDSYHNLRLSIHDMPQAHWRSKLLAGY-QEIPFYHIWNG-SQRYLHCTFTLERLSLSTCELT----- -------------------------------------------------------------------------------- ---------------------------------------------------------CQLCVWQVEGEGQSFSLDFNIAK --------------------------------DTRAIDAEFMLMDSNATALAGPSAFQIPYLIRQKICSSLDAPCPNG-- -ADWRMLAQRLKLE----RHMSFFASKSS----PTSVILDLWEAQHFHS---------GNINQLAAVMADIGKQEAMIFL -----------VSDGEC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Gasterosteus_aculeatus_UNC5A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------TLPAAF------SDLLPHFLVEPEDEFIVKNKPV TLTCRSSPATQIYFKCNGEWVHQDDHLIERTVDPATALP----------------------------------------- ---------------------------IMQVTIDITRQQVEKIFG--LDEYWCQCVAWST--TGTQKSQK---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYIRIAYLRKN--------------- ---FEEEPQGKEVALDQEVLLRCHPPEGVPQAEVEWQRNEDVITPASDPNVFITTDY----------------------- ------------------------------------------------------------------NLVIKKARLADTGN YTCVAKNIVARRKSTSA------------------TVLVY--------------------------------------VN GGWST-WTTWSSCSAV---------------CGRGWQKRSRSCTNPTPLNGGTSCEGQNVQKSACVATCP---------- -------------------------------------------------------------------------------- ------------------------------VDGGWSEWSKWSACGADCSM------------------------------ -------------------------------------------------------------------------------- ----------WRSRECTQPSPGTGGK---DCQGLDLQSLNCTSEQCPQIVLIL----IFLPSHPPP-----PLP-SAVSG AEDVALYVG----MVAVALCLTLLLIVVVLVYRRKKEDL----------------------------------------- ----------DADVADSS----ILTTG-FQPMGIKP---KNS-------------------------------HLLTIQP DLTTTTTSYQGTLRSRH-----DT-TGKFSMTNGPLLD------------------------------------------ -------------------------------------------------------------------------------- -PLPNGSHTLHNGKLNS-----------DPAEFVSR-------------------------------------------- --LSTQS-------YFKTLPRDVANSSYGTFNFLG----------------------GRLTIPST--------------- ---------------------------------------------------------------------------GISLL IPPEAIPRGKIYEIYLTVQRKEDL-------------------------------------------------------- ---------------------------------------RLPLAGCQTLLSPVVSCGPPGVVLSRPVILSMDHCSDACLD --NWAIRLKKQN------------------YEGTWE-------------------------------------------- -------------------------------DVLLMGEEL------------VSEPYYCQLEAETCRLFSEQLGT-LALV GES---LHMG-AAKRLRLVLFSD-AYCSTLEYNIRVY---------------CMDDTQDVFKE-VMQMERQLG------- ------------------------------------------------------------------------------GR LIDEPH---VLLFKDSYHNLRLSIHDMPQAHWRSKLLAGY-QEIPFYHIWNG-SQRYLHCTFTLERLSLSTCELT----- -------------------------------------------------------------------------------- ---------------------------------------------------------CQLCVWQVEGEGQSFSLDFNIAK --------------------------------VTLAIRIPLLEPDSTAAALAGPSAFQIPYLIRQKICSSLDAPCPNG-- -ADWRMLAQRLKLES---RHMSFFASKAS----PTSVILDLWEAQHFHS---------GNINQLATVMADIGKQEAMIFL -----------VSDGEC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Oryzias_latipes_UNC5A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------RSYRGARGAAKSFLFMCHWRKSNNSKNVKSSEYAATAALPAAF------SDRLPHFLVEPEDKYIVKNKPV TLTCRSTPATQIYFKCNGEWVHQDDHYIEHSVDPATGLP----------------------------------------- ---------------------------VMWVTIDITRQQVEKIFG--LDEYWCQCVAWST--TGTQKSQK---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYIRIAYLRKN--------------- ---FEEEPQSKEVALDQEVSLRCHPPEGVPPAEVEWQRNEDLVDPTSDPNFVITPDH----------------------- ------------------------------------------------------------------NLVIKAARLADTGN YTCVAKNIVARRKSNSA------------------TVLVF--------------------------------------VN GGWST-WTTWSSCSAV---------------CGRGWQKRSRSCTNPTPLNGGTSCEGQNVQKSACVATCP---------- -------------------------------------------------------------------------------- ------------------------------VDGGWSEWSKWSACGADCSM------------------------------ -------------------------------------------------------------------------------- ----------WRSRECTQPSPGTGGK---DCQGLDLQSLNCTSEQCPQICT------------SLN-----VQQLRAVRG AEDVALYVG----MVAVALCLTLLLIVVVLVYRRKKEGL----------------------------------------- ----------DADVADSS----ILTTG-FQPMGIKPSKPENS-------------------------------HLLTIQP DLTTTTTSYQGTLRSRH-----DA-TAKFSMTNGPLLD------------------------------------------ -------------------------------------------------------------------------------- -PLPNGSHTLHNGKLNP-----------DPAEFVSR-------------------------------------------- --FSTQS-------YFKTLPRDVANTSYGTFNFLG----------------------GRLTIPNT--------------- ---------------------------------------------------------------------------GISLL IPPEAIPRGKIYEIYLTVQRKEDL-------------------------------------------------------- ---------------------------------------RLPLAGCQTLLSPVVSCGPPGVVLSRPVILSMDHCFDACLD --NWAVRLKKQN------------------YEGTWE-------------------------------------------- -------------------------------DVLLMGEEL------------VSEPFYCQLEAETCRLFSEQLGT-FAVV GES---LHMG-AAKRLRLVLFSD-AYCSTLEYNIRVY---------------CMDDTQDVFKE-VMQMERQLG------- ------------------------------------------------------------------------------GR LIDEPH---VLLFKDSYHNLRLSIHDMPQAHWRSKLLAGY-QEIPFYHIWNG-SQRYLHCTFTLERLSLSTCELT----- -------------------------------------------------------------------------------- ---------------------------------------------------------CQLCVWQVEGEGQSFSLDFNIAK --------------------------------DTRAVDSEFLVMDSNATALAGPSAFQIPYLIRQKICSSLDAPCPNG-- -ADWRMLAQRLKLE----RHMSFFASKAS----PTSGILDLWEAQHFHS---------GNINQLAAVMADIGKQEAMIFL -----------VSDGDC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Oryzias_latipes_UNC5A_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------DDDFAGLGELPETFPSDP------PEPLPVFLMEPEEAYIVKNKPV NLYCKATPATQIYFKCNSEWVHQKEHTVEERVDENS-------------------------------------------- ------------------------GLVVREASIEITRQQVEELFG--PEDFWCQCVAWSS--AGTTKSRK---------- -------------------------------------------------------------------------------- ------------------------------------------------------AHVRIAYLRKP--------------- ---FDQEPLGKEVSIEQEVLLQCRPPEGIPPAEVEWLKNDEIIDPAEDRNFYITIDH----------------------- ------------------------------------------------------------------NLIIKQARLSDTAN YTCVAKNIVAKRYSTTA------------------TVIVY--------------------------------------VN GGWST-WTEWSVCNSR---------------CGRGYQKRTRSCTNPAPLNGGAICDGQGIQKLPCNPLCPGGV------- -------------------------------------------------------------------------------- -----------------------------IVDGLWTEWSKWSTCGTECTH------------------------------ -------------------------------------------------------------------------------- ----------WRRRDCGAPAPKNGGK---DCEGTVLQSKNCTDGLCMQSSLNP----KSSEAKG-----KNDLGNSLAPS TDDVALYVGI---VIAVIMCLVISVVVALFVYRRNHRDF----------------------------------------- ----------SSDILDSS----ALNGG-FQPVSIKTAR---------------------------------KADLLTAPP DLTSAAALYRGPVYALH------DVADKIPMTNSPLLE------------------------------------------ -------------------------------------------------------------------------------- -PLPNLKIKVYNSSGLVT-----------PQDDLGGEFSSKLSP----KLP-----------------------HCLLDN SDSTMGRRTQ---SQTLLRTRDPSCTALGSFS-----SQG-----------------GQLIVP----------------- -------------------------------------------------------------------------NSGVSLL IPAGAVPQGRVYEMYVTVQRKENL-------------------------------------------------------- ---------------------------------------RPSVEDGQTVLSPVVSCGPPGALLTRPVVITMHHCAVCDGQ -QDWLIQLKSQS------------------QQNQWE-------------------------------------------- -------------------------------DVVVVGEEN------------FTTPCYVQMDDEACHILTETLGT-YCLV GQS---LSAA-TIKRLKLAIFGP-VTCAAMEYHIRVY---------------CLDDTQDALKE-VLQMEKQMG------- ------------------------------------------------------------------------------GK LLDEPK---TLSFKDSTHNLRLSIHDVPHMMWKSKLLAKY-QELSFQQVWSG-SQRNLHCCFTLERFSTSTVDLT----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKICVRQVEGEGQIFQLDTTLSE DS-----------------------------QSIDTSLLDPA---SNITTLVGPNAFRIPVSIRQKLCSSLDAPQTRG-- -NDWRMLAHKLNLD----RYLNYFATKSS----PTGVILDLWEAQHFPD---------GNLSRLAQVLEEMGRHDSLVPA -----------VFEH----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Homo_sapiens_UNC5B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MGARSGAR-GALLLALLLCWDP--------RLSQAGTDSGSEVLPDSFPSAP------AEPLPYFLQEPQDAYIVKNKPV ELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLR----------------------------------------- ---------------------------VREVQIEVSRQQVEELFG--LEDYWCQCVAWSS--AGTTKSRR---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYVRIAYLRKN--------------- ---FDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDH----------------------- ------------------------------------------------------------------NLIIRQARLSDTAN YTCVAKNIVAKRRSTTA------------------TVIVY--------------------------------------VN GGWSS-WAEWSPCSNR---------------CGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICP---------- -------------------------------------------------------------------------------- ------------------------------VDGAWTEWSKWSACSTECAH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECMAPPPQNGGR---DCSGTLLDSKNCTDGLCMQNK-----------------KTLSDPNSHLLEA SGDAALYAGL---VVAIFVVVAILMAVGVVVYRRNCRDF----------------------------------------- ----------DTDITDSSA---ALTGG-FHPVNFKTARPSN-----------------------------PQLLHPSVPP DLTASAGIYRGPVYALQ------DSTDKIPMTNSPLLD------------------------------------------ -------------------------------------------------------------------------------- -PLPSLKVKVYSSSTTGS-----------GPGLADGADLLGVLP----PGTYPS--------------------DFARDT HFLHLRSASL-GSQQLLGLPRDPGSSVSGTFG-----CLG-----------------GRLSIP----------------- -------------------------------------------------------------------------GTGVSLL VPNGAIPQGKFYEMYLLINKAESTLP------------------------------------------------------ -----------------------------------------LSEGTQTVLSPSVTCGPTGLLLCRPVILTMPHCAEVSA- -RDWIFQLKTQA------------------HQGHWE-------------------------------------------- -------------------------------EVVTLDEET------------LNTPCYCQLEPRACHILLDQLGT-YVFT GES---YSRS-AVKRLQLAVFAP-ALCTSLEYSLRVY---------------CLEDTPVALKE-VLELERTLG------- ------------------------------------------------------------------------------GY LVEEPK---PLMFKDSYHNLRLSLHDLPHAHWRSKLLAKY-QEIPFYHIWSG-SQKALHCTFTLERHSLASTELT----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKICVRQVEGEGQIFQLHTTLAE TPAG----------------------------SLDTLCSAPG---STVTTQLGPYAFKIPLSIRQKICNSLDAPNSRG-- -NDWRMLAQKLSMD----RYLNYFATKAS----PTGVILDLWEALQQDD---------GDLNSLASALEEMGKSEMLVAV -----------ATDGDC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Macaca_mulatta_UNC5B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MWTRSGAR-DALLLALLLCWDP--------RLSQAGTDSGSEALPDSFPSAP------AEPLPYFLQEPQDAYIVKNKPV ELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLR----------------------------------------- ---------------------------VREVQIEVSRQQVEELFG--LEDYWCQCVAWSS--AGTTKSRR---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYVRIAYLRKN--------------- ---FDQEPLGKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPTQDTNFLLTIDH----------------------- ------------------------------------------------------------------NLIIRQARLSDTAN YTCVAKNIVAKRRSTTA------------------TVIVY--------------------------------------VN GGWSS-WAEWSPCSNR---------------CGRGWQKRTRTCTNPTPLNGGAFCEGQAFQKTACTTICP---------- -------------------------------------------------------------------------------- ------------------------------VDGAWTEWSKWSACSTECAH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECMAPPPQNGGR---DCSGTLLDSKNCTDGLCMQNK-----------------KTLSDPNSHLLEA SGDAALYAGL---VVAVFVVVAILMAVGVVVYRRNCRDF----------------------------------------- ----------DTDITDSSA---ALTGG-FHPVNFKTARPNN-----------------------------PQLLHPSVPP DLTASAGIYRGPVYALQ------DSTDKIPMTNSPLLD------------------------------------------ -------------------------------------------------------------------------------- -PLPSLKVKVYSSSTTGS-----------GPGLADGADLLGVLP----PGTYPS--------------------DFTRDT HLLHLRSASL-GSQQLLGLPRDPGSSVSGTFG-----CLG-----------------GRLSIP----------------- -------------------------------------------------------------------------GTGVSLL VPNGAIPQGKFYEMYLLINKAESTLP------------------------------------------------------ -----------------------------------------LSEGTQTVLSPSVTCGPTGLLLCRPVILTVPHCAKVSV- -GDWIFQLKTQA------------------HQGHWE-------------------------------------------- -------------------------------EVVTLDEET------------LNTPCYCQLEPRACHILLDQLGT-YVFT GES---YSRS-AVKRLQLAVFAP-ALCTSLEYSLRVY---------------CLEDTPVALKE-VLDLERTLG------- ------------------------------------------------------------------------------GY LVEEPK---PLMFKDSYHNLRLSLHDLPHAHWRSKLLAKY-QEIPFYHIWSG-SQKALHCTFTLERHSLASTELT----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKICVRQVEGEGQIFQLHTTLAE TPAG----------------------------SLDTLCSAPG---SAVTTQLGPYAFKIPLSIRQKICNSLDAPNSRG-- -NDWRMLAQKLSMD----RYLNYFATKAS----PTGVILDLWEALQQDD---------GDLNSLASALEEMGKSEMLVAV -----------ATDGDC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Mus_musculus_UNC5B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- MRARSGVR-SALLLALLLCWDP--------TPSLAGVDSAGQVLPDSYPSAP------AEQLPYFLLEPQDAYIVKNKPV ELHCRAFPATQIYFKCNGEWVSQNDHVTQESLDEATGLR----------------------------------------- ---------------------------VREVQIEVSRQQVEELFG--LEDYWCQCVAWSS--SGTTKSRR---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYIRIAYLRKN--------------- ---FDQEPLAKEVPLDHEVLLQCRPPEGVPVAEVEWLKNEDVIDPAQDTNFLLTIDH----------------------- ------------------------------------------------------------------NLIIRQARLSDTAN YTCVAKNIVAKRRSTTA------------------TVIVY--------------------------------------VN GGWSS-WAEWSPCSNR---------------CGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTVCP---------- -------------------------------------------------------------------------------- ------------------------------VDGAWTEWSKWSACSTECAH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECMAPPPQNGGR---DCSGTLLDSKNCTDGLCVLNQ-----------------RTLNDPKSHPLET SGDVALYAGL---VVAVFVVVAVLMAVGVIVYRRNCRDF----------------------------------------- ----------DTDITDSSA---ALTGG-FHPVNFKTARPNN-----------------------------PQLLHPSAPP DLTASAGIYRGPVYALQ------DSADKIPMTNSPLLD------------------------------------------ -------------------------------------------------------------------------------- -PLPSLKIKVYNSSTIGS-----------GSGLADGADLLGVLP----PGTYPG--------------------DFSRDT HFLHLRSASL-GSQHLLGLPRDPSSSVSGTFG-----CLG-----------------GRLSLP----------------- -------------------------------------------------------------------------GTGVSLL VPNGAIPQGKFYDLYLHINKAESTLP------------------------------------------------------ -----------------------------------------LSEGSQTVLSPSVTCGPTGLLLCRPVVLTVPHCAEVIA- -GDWIFQLKTQA------------------HQGHWE-------------------------------------------- -------------------------------EVVTLDEET------------LNTPCYCQLEAKSCHILLDQLGT-YVFM GES---YSRS-AVKRLQLAIFAP-ALCTSLEYSLRVY---------------CLEDTPVALKE-VLELERTLG------- ------------------------------------------------------------------------------GY LVEEPK---PLLFKDSYHNLRLSLHDIPHAHWRSKLLAKY-QEIPFYHVWNG-SQRALHCTFTLERHSLASTEFT----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKVCVRQVEGEGQIFQLHTTLAE TPAG----------------------------SLDALCSAPG---NAITTQLGPYAFKIPLSIRQKICSSLDAPNSRG-- -NDWRLLAQKLSMD----RYLNYFATKAS----PTGVILDLWEARQQDD---------GDLNSLASALEEMGKSEMLVAM -----------ATDGDC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Gallus_gallus_UNC5B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M PPARRLLLPFFLLLLLPLHLRWA--------LAAAGLEYS-EVLPDSFPSAP------AETLPHFLREPQDAYIVKNKPV ELVCRANPATQIYFKCNGEWVNQNDHVTTESLDEVTG------------------------------------------- ------------------------L-LVREVQIEVSRQQVEELFG--LEDYWCQCVAWSS--AGTTKSRR---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYVRIAYLRKN--------------- ---FDQEPLGKEVPLEQEVLLQCRPPEGVPQAEVEWLRNEDVIDPTQDTNFLITIDH----------------------- ------------------------------------------------------------------NLIIKQARLLDTAN YTCMAKNIVAKRRSTTA------------------AVIVY--------------------------------------VN GGWST-WSEWSPCNNR---------------CGRGWQKRTRTCTNPAPLNGGSFCDGQPFQKVTCTTLCP---------- -------------------------------------------------------------------------------- ------------------------------VDGAWTEWSKWSACSTECTH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECSAPAPRNGGK---DCSGGLLDSKNCTDGLCLHNK-----------------RVLSEPKSHLLEA TGDVALYAGL---VVAIFVFIVILMAVGVVVYRRRCRDF----------------------------------------- ----------DTDITDSSA---ALTGG-FHPVNFKTARH-DN----------------------------PQLLHPSMQP DLTANAGVYRGPMYALQ------DSSDKIPMTNSPLLD------------------------------------------ -------------------------------------------------------------------------------- -PLPNLKIKVYNSSTTSS-----------SPGLHDGTDLLGGIPA---VGTFPG--------------------DSS--S QFVNMRNKAQQGSQHLLSLPREHGTSASGTFS-----YLG-----------------GRLTIP----------------- -------------------------------------------------------------------------GTGVSLL VPHGAIPQGKFYEIYLVINKAESGLLP----------------------------------------------------- ------------------------------------------SEGTQTVLSPAVTCGPTGLLLCRPVVLTIPHCADVSS- -SDWIFQLKTQS------------------HQGNWE-------------------------------------------- -------------------------------EVVTLDEET------------LNTPCYCQLEAKSCHVLLDQLGT-YVFV GES---YSRS-AIKRLQLAIFAP-AICTSLEYSLKVY---------------CLEDTPDALKE-VLELERTLG------- ------------------------------------------------------------------------------GY LLEEPK---PLPFKDSYHNLRLSIHDIPHSLWRSKLLAKY-QEIPFYHIWSG-SQRALHCTFTLERYSQASTELT----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKICVRQVEGEGQIFQLHVTLGE HAN-----------------------------SFDTLHSHNS---SAPTTQLGPYAFKIPLSIRQKICNSLDAPNSRG-- -NDWRLLAQKLSMD----RYLNYFATKAS----PTGVILDLWEAEHQDD---------GDLNTLASALEEMGKSEMLVVM -----------ATEGDC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Xenopus_tropicalis_UNC5B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------GIEYS-DVLPDSFPSAP------AESLPHFLLEPEDAYIVKNKPV ELVCKANPATQIYFKCNGEWVNQNDHITKERVDEVTASLG---------------------------------------- ------------------------L-VVREVQIEVSRQQVEELFG--LEDYWCQCVAWSS--AGTTKSKR---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYVRIAYLRKN--------------- ---FDQEPLGKEVALEQEALLQCRPPEGVPPAEVEWLKNEEIIDPTKDTNFLITIDH----------------------- ------------------------------------------------------------------NLIIKQARLSDTAN YTCVAKNIVAKRRSTTA------------------TVIVF--------------------------------------VN GGWSS-WTEWSPCNNR---------------CGHGWQKRTRTCTNPAPLNGGTMCEGQQYQKFACNTMCP---------- -------------------------------------------------------------------------------- ------------------------------VDGGWTAWSKWSACSTECTH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECNAPTPKNGGK---DCSGMLLDSKNCTDGLCMQNK-----------------RVLGETKSHLLES TGDVALYAGL---VVAIFIVIILLMAVGIVVYRRNCREL----------------------------------------- ----------DTDITDSSA---ALTGG-FHPVNFKTSRHADN----------------------------SHLIHPAMQP DLTANAGIYRGHMYALQ------DSADKIPMTNSPLLD------------------------------------------ -------------------------------------------------------------------------------- -PLPNLKIKVFNSSTVGS-----------SPGIHDGNDLLGVKP----TGTYPS--------------------DNN--- -IMNARNKNM-STQHLLTLPRDSSNSVTGTFG-----SLG-----------------GRLTFPNT--------------- -------------------------------------------------------------------------ATGVSLL IPQGAIPQGKYYEMYLMINKRENTVLP----------------------------------------------------- ------------------------------------------SEGTQTILSPIITCGPTGLLLCKPVILTVPHCADIAT- -SDWILQLKTQS------------------HQGNWE-------------------------------------------- -------------------------------EVVTLNEET------------LNTPCYCQLESHSCHILLDQLGT-YAFV GES---YSKS-AIKRLQLAIFAP-MLCTSLEYNLKVY---------------CVEDTPDALKE-VLELEKTLG------- ------------------------------------------------------------------------------GY LVEDPK---PLMFKDSYHNLRLSIHDIPHSLWRSKLLAKY-QEIPFYHIWSG-SQRTLHCTFTLERYSLAATELT----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKICVRQVEGEGQIFQLHTSLEE NVK-----------------------------SFDPFCSHTEN---SVTTQLGPYAFKIPYSIRQKICNSLDAPNSRG-- -NDWRLLAQKLCMD----RYLNYFATKAS----PTGVILDLWEALHQDD---------GDLNTLASALEEMGKSEMMLVM -----------ATDGDC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Danio_rerio_UNC5B_a -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ML STWIHRDQSPASLLGLLLLSSTL--------VIHADGSDYSEVLPDSFPSAP------AEPLPEFQSEPEDAFIVKNRPV KLSCKAAPATQIYFKCNGEWVNQNDHVTKESLDHITGLV----------------------------------------- ---------------------------VREVDISVSRTQVEELFG--LEDYWCQCVAWSS--AGTTKSRR---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYVRIAYLRKN--------------- ---FEQEPLGREVRLEQEVLLQCRPPEGSPPAEVDWLKNEELIDPALDSNFLITIEH----------------------- ------------------------------------------------------------------DLIIKQARLSDTAN YTCVARNVVAKRRSSTA------------------TLIVY--------------------------------------VS GGWSS-WTEWSECNAQ---------------CGRGWQRRTRSCTNPAPLNGGAFCDGPPFQRVTCTTLCP---------- -------------------------------------------------------------------------------- ------------------------------VDGGWTEWAKWSACGTECTH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECQAPPPRNGGR---HCSGSMMESKNCTEGLCARNK-----------------KVSVEHTSHPLGS GTGVAVYAGL---VGALLLCVILVLCVGILVYRRSCRHL----------------------------------------- ----------HGEITDSSS---ALTAA-FHPGNYKPPRQDN-----------------------------PHLLHPTAPP DLTASAGTFRGPLFSLQQA--TLDSHHKIPMTTSPLLD------------------------------------------ -------------------------------------------------------------------------------- -PLPSLKIKVYNSSTMSS-----------LELPTGLGSVDGDIM------------------------------------ SLKTVGSGPK--DHHGHTLPREPSHSASATLG-----SLG-----------------GRLTIP----------------- -------------------------------------------------------------------------NTGVSLL VPPGTIPQGKFYEMYLIINKWEKTTLP----------------------------------------------------- ------------------------------------------SDGSQTVLSPVVSCGPSGMLLSRPVVLTLPHCAQLEP- -PDWTLTLKMQN------------------HQGAWE-------------------------------------------- -------------------------------EVLTVGEES------------LSSPCYLQVEEQSCHILMEQLGT-YGLV GQS---APPRPACKRLQLALFAPRAPCLSLDYSLRVY---------------CIQDTPHALKE-VLEVERSLG------- ------------------------------------------------------------------------------GV LLEDPK---PLLFKDSYHNMRLSIHDIPHSHWRSKLLAKY-QEIPFYHIWSG-SQRPLHCTFSLERGSLVVSQLT----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKICVRQVEGEGQIFQLNTDIQE --------------------------------TLPPHSPLPAGGSCLPSSQVGPYAFRLPVSIRQKICASLDAPSARG-- -CDWRMLARSLAFD----RYLNYFATKPS----PTGVLLDLWEACHQGD---------ADLVSLATALEEMGKSEVLVVM -----------TTDGDC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Takifugu_rubripes_UNC5B_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------SDAEVLPDSFPSAP------AEPLPEFLLEPEDAFIVKNRPV QLRCRASPATQIYFKCNGEWVNQNDHITRESLDQITGLV----------------------------------------- ---------------------------VREVEISVSRTQVEELFG--LEDYWCQCVAWSS--AGTTKSNR---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYVRIAYLRKN--------------- ---FEQEPLGREVRLEQEVLLQCRPPEGMPAAEVDWLKNEDAIDPSQDSNFLITIDH----------------------- ------------------------------------------------------------------DLIIKQARLSDTAN YTCVARNVVAKRRSSTA------------------TLIVYGSCLAVVFKIEFNCRARSHLPSVCPSPS----------VS GGWSS-WTEWSECNAQ---------------CGRGWQRRTRSCTNPAPLNGGAFCEGPPFQRVTCTTLCP---------- -------------------------------------------------------------------------------- ------------------------------VDGGWTEWAKWSACGTECTH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECQAPPPRNGGK---HCSGSMMESKNCTEGLCARYK-----------------KVSIEHASHPLAP DTGVAVYAGL---VGALLLCVILVLCVGVLAYRRRCRHL----------------------------------------- ----------HGDITDSSS---ALTAA-FHPGNYKPSRQDN-----------------------------PNPLHPSAPP DLTATAGTFRGPLFSLQQG--ANDSPHKIPMTTSPLLD------------------------------------------ -------------------------------------------------------------------------------- -PLPSLKIKVYNSSTLSS-----------LELPADVR-SDGEIL------------------------------------ SLNSVGTVGRERDYYSHTLSREPGLSTSATLG-----NLG-----------------GRLTIP----------------- -------------------------------------------------------------------------NTGVSLL VPPGTIPQGKFYEMYLIINKWDKMTLP----------------------------------------------------- ------------------------------------------SEGSQTVLSPVVSCGPSGMLLNRPVVLTLPHCAQLDTP TPDWTLTLKTQT------------------HQGAWE-------------------------------------------- -------------------------------EVLTVGEET------------LSSPCYLQLEEECCHVLMEQLGT-YGLV GQS---CPPQPACKRLQLALFAPRAPCLSLDYSLRIY---------------CIHDTPHALKD-VLDLERSLG------- ------------------------------------------------------------------------------GV LLEDPK---PLLFKDSYHNLRLSIHDIPHTHWRSKLLAKY-QEIPFYHIWSG-SQRPLHCTFSLERSSLAVSQLT----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKICVRQVEGEGQIFQLHTDIQE VVKRRRCHKILSSAFEKNDALRS-------FQTLPPHSPLPSGGSCPPSSQVGPYAFRLPDSIRQKICASLDVPSARG-- -CDWRLLARSLGFD----RYLNYFATKPS----PTGVLLDLWEACHQAD---------ADLVSLATALEDMGKSEVLVVM -----------TTDGDC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Tetraodon_nigroviridis_UNC5B_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------SEAEVLPDSFPSAP------AEPLPEFLLEPEDAFIVKNRPV QLRCRASPATQIYFKCNGEWVNQNDHITRESLDQITGLV----------------------------------------- ---------------------------LREVEISVSRTQVEELFG--LEDYWCQCVAWSS--AGTTKSNR---------- -------------------------------------------------------------------------------- ------------------------------------------------------AYVRIAYLRKN--------------- ---FEQEPLGREVRLEQEVLLQCRPPEGMPAAEVDWLKNEDVIDPSQDSNFLITIDH----------------------- ------------------------------------------------------------------DLIIKQARLSDTAN YTCVARNVVAKRRSSTA------------------TLIVY--------------------------------------VS GGWSS-WTEWSECNAQ---------------CGRGWQRRTRSCTNPAPLNGGAFCEGPPFQRVTCTTLCP---------- -------------------------------------------------------------------------------- ------------------------------VDGGWTEWAKWSACGTECTH------------------------------ -------------------------------------------------------------------------------- ----------WRSRECQAPSPRNGGK---HCSGSMMESKNCTEGLCAR----------------------------SLAP DTGVAVYAGL---VGALLLCVILVLCVGVLAYRRRCRHL----------------------------------------- ----------HGDITDSSS---ALTAA-FHPGNYKPSRQDN-----------------------------PNPLHPSAPP DLTATAGTFRGPLFSLQQG--VNDSPHKIPMTTSPLLD------------------------------------------ -------------------------------------------------------------------------------- -PLPSLKIKVYNSSTLSS-----------LELPADVC-SDGEIL------------------------------------ SLKSVGTVGRERDCYGHTLSREPGLSTSATLG-----NLG-----------------GRLTIP----------------- -------------------------------------------------------------------------NTGVSLL VPPGTIPQGKFYEMYLIINKWDKMTLP----------------------------------------------------- ------------------------------------------SEGSQTVLSPVVSCGPSGMLLNRPVVLTLPHCAQLDSP TPDWTLTLKTQT------------------HQGAWE-------------------------------------------- -------------------------------EVLTVGEET------------LSSPCYLQLEEECCHLLMEQLGT-YGLV GQS---CPPQPACKRLQLALFAPRAPCLSLDYSLRIY---------------CIHDTPHALKE-VLDLERSLG------- ------------------------------------------------------------------------------GV LLEDPK---PLPFKDSYHNLRLSIHEIPHTHWRSKLLAKY-QEIPFYHIWSG-SQRPLHCTFSLERSSLAVSQLA----- -------------------------------------------------------------------------------- ---------------------------------------------------------CKICVRQVEGEGQIFQLHTDIQE --------------------------------TLPPHSPLPSGGSCLPSSQVGPYAFRLPDSIRQKICASLDAPSARG-- -CDWRLLARSLGFD----RYLNYFATKPS----PTGVLLDLWEACHQGD---------ADLVSLATALEEMGKSEVLVVM -----------TTDGDC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------- >Gasterosteus_aculeatus_UNC5B_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------A VSYTHILPFGCLFISYLSNSWVT--------AKE