>Homo_sapiens_TSPAN5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MSGK HYKG-------------------------------PEVSCCIKYFIFGFN---VIFWFL--------------------G -ITFLGIGLWAWNEKGVL--SNISSITDLGG------FDPVWLF---LVVGGVMF-ILGFAGCIGALRENTFLLKFF--- -SVFLGIIFFLELTAG--VLAFVFKD---WIKDQLY-FFINNNIRAYRDDIDLQNL-----------------IDFTQEY --WQCCG----------AFGADDWN----LNIYFNC--TDSNA------------SRERCGVPFSCCTKDPAED------ VINTQCGYDAR------------------QKPEVDQQIVIYTKGCVP-QFEKWLQDNLTIVAGIFIG---IALL---QIF G-----------------ICLAQNLVSDIE---------AVRA----SW------------------------------- -------------------------------------------------------------------------------- ----- >Mus_musculus_TSPAN5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MSGK HYKG-------------------------------PEVSCCIKYFIFGFN---VIFWFL--------------------G -ITFLGIGLWAWNEKGVL--SNISSITDLGG------FDPVWLF---LVVGGVMF-ILGFAGCIGALRENTFLLKFF--- -SVFLGIIFFLELTAG--VLAFVFKD---WIKDQLY-FFINNNIRAYRDDIDLQNL-----------------IDFTQEY --WQCCG----------AFGADDWN----LNIYFNC--TDSNA------------SRERCGVPFSCCTKDPAED------ VINTQCGYDAR------------------QKPEVDQQIVIYTKGCVP-QFEKWLQDNLTIVAGIFIG---IALL---QIF G-----------------ICLAQNLVSDIE---------AVRA----SW------------------------------- -------------------------------------------------------------------------------- ----- >Rattus_norvegicus_TSPAN5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MSGK HYKG-------------------------------PEVSCCIKYFIFGFN---VIFWFL--------------------G -ITFLGIGLWAWNEKGVL--SNISSITDLGG------FDPVWLF---LVVGGVMF-ILGFAGCIGALRENTFLLKFF--- -SVFLGIIFFLELTAG--VLAFVFKD---WIKDQLY-FFINNNIRAYRDDIDLQNL-----------------IDFTQEY --WQCCG----------AFGADDWN----LNIYFNC--TDSNA------------SRERCGVPFSCCTKDPAED------ VINTQCGYDAR------------------QKPEVDQQIVIYTKGCVP-QFEKWLQDNLTIVAGIFIG---IALL---QIF G-----------------ICLAQNLVSDIE---------AVRA----SW------------------------------- -------------------------------------------------------------------------------- ----- >Xenopus_tropicalis_TSPAN5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MSGK HYKG-------------------------------PEVSCCIKYFIFGFN---VIFWLL--------------------G -ITFLGVGLWAWSEKGVL--SNISSITDLGG------FDPVWLF---LVVGGVMF-ILGFAGCIGALRENTFLLKFF--- -SVFLGIIFFLELTAG--VLAFVFKD---WIKDQLQ-FFINNNIRAYRDDIDLQNL-----------------IDFTQEY --WQCCG----------AFGADDWN----LNIYFNC--TDANA------------SRERCGVPFSCCTKDPAED------ VINTQCGYDVR------------------QKPELDQQETIHTKGCVP-QFEKWLQDNLTIVAGVFIG---IALL---QIF G-----------------ICLAQNLVSDIE---------AVRA----SW------------------------------- -------------------------------------------------------------------------------- ----- >Danio_rerio_TSPAN5a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MLAGSFVLEINEPMMTGK HYKG-------------------------------QEVSCCIKYFIFGFN---IIFWLL--------------------G -VAFLGIGLWAWSEKGVL--SNISSITDLGG------FDPVWLF---LVVGGVMF-ILGFAGCIGALRENTFLLKFF--- -SVFLGIIFFLELTAG--ILAFVFKD---WIKDQLN-FFINNNIRAYRDDIDLQNL-----------------IDFTQEY --WECCG----------AFGADDWN----LNIYFNC--TDSNP------------SREKCGVPFSCCTKDPAED------ VINTQCGYDVR------------------AKPDAEQKTYIHVKGCVP-QFEKWLQDNLTVVAGIFIG---IALL---QIF G-----------------ICLAQNLVSDIE---------AVRA----SCLFT---------------------------- -------------------------------------------------------------------------------- ----- >Takifugu_rubripes_TSPAN5a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MSGN HYKG-------------------------------HEVSCCIKYFIFGFN---ILFWLL--------------------G -MALVGIGLWAWSEKGVL--SNISSITDLGG------LDPVWLF---MVVGGVMF-ILGFAGCIGALRENTFLLKFF--- -SVFLGIIFFLELTTG--VLAFVFKD---WIKDQLN-LFINNNIRAYRDDIDLQNL-----------------IDFTQEY --WECCG----------AFGADDWN----LNIYFNC--TDGNP------------SREKCGVPFSCCTKDPAED------ VINTQCGYDVR------------------AKPDSEQKDSINVKGCVP-QFEKWLQDNLTLVAGIFIG---VALL---QIF G-----------------ICLAQNLVSDIE---------AVQA----SCFFT---------------------------- -------------------------------------------------------------------------------- ----- >Takifugu_rubripes_TSPAN5b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MSGK HFKA-------------------------------HEVSCCIKYFIFGFN---VIFWFL--------------------G -VAFLAIGLWAWSEKGVL--SNISSITDLGG------FDPVWLF---LVVGGVMF-ILGFAGCIGALRENSFLLKFF--- -SVFLGIIFFLELX-------LFFKD---WIKDQLN-FFINNNIRAYRDDIDLQNL-----------------IDFTQEY --WECCG----------AFGADDWN----LNIYFNC--TDSNP------------SREKCGVPFSCCTKDPGED------ VINTQCGYDIR------------------AKTDSEQRTHIYMKGCVP-QFEKWLQDNLTVVAGIFIG---IALL---QIF G-----------------ICLAQNLVSDIE---------AVRE----SCLFT---------------------------- -------------------------------------------------------------------------------- ----- >Tetraodon_nigroviridis_TSPAN5a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------PARRPASGQMMPGK YFKA-------------------------------HEVSCCIKYFIFGFN---IIFWFL--------------------G -VAFLAIGLWAWSEKGVL--SNISSITDLGG------FDPVWLF---LVVGGVMF-ILGFAGCIGALRENSFLLKFF--- -SVFLGIIFFLELTAG--VLAFVFKD---WIKDQLN-FFINNNIRAYRDDIDLQNL-----------------IDFTQEY --WECCG----------AFGADDWN----LNIYFNC--TDSNP------------SREKCGVPFSCCTKDPGED------ VINTQCGYDIR------------------AKADSEQRTHIYIKGCVP-QFEKWLQDNLTVVAGIFIG---IALL---QIF G-----------------ICLAQNLVSDIE---------AVRE----SW------------------------------- -------------------------------------------------------------------------------- ----- >Gasterosteus_aculeatus_TSPAN5a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MSGN QYKG-------------------------------NDVSCCIKYFIFGFN---ILFWLL--------------------G -MALVGIGLWAWSEKGVL--SNISSITDLGG------LDPVWLF---MVVGGVMF-ILGFAGCIGALRENTFLLKFF--- -SVFLGIIFFLELTTG--VLAFVFKD---WIKDQLN-LFINNNIRAYRDDIDLQNL-----------------IDFTQEY --WECCG----------AFGADDWN----LNIYFNC--TDGNP------------SREKCGVPFSCCTKDPAED------ VINTQCGYDIF------------------CAKGRQKENVVSLLQARP-AFEKCCRT-TPLVAGISCY---PFLLFHPQIF G-----------------ICLAQTLVSDIE---------AVQA----SCFFT---------------------------- -------------------------------------------------------------------------------- ----- >Oryzias_latipes_TSPAN5a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------CSNMSGN PYKGG------------------------------HEVSCCIKYFIFGFN---ILFWLL--------------------G -MALVGIGIWAWSEKGVL--SNISSITDLGG------LDPVWLF---VVVGGVMF-ILGFAGCIGALRENTFLLKFF--- -SVFLGIIFFLELTAG--ILAFVFKD---WIKDQLN-LFINNNIRAYRDDIDLQNL-----------------IDFTQEY --WECCG----------AFGVDDWN----LNIYFNC--TDGNP------------SREKCGVPFSCCTKDPAED------ VINTQCGYDIR------------------AKPDSEQKDYINVKGCVP-QFEKWLQDNLTLVAGIFIG---VALL---QIF G-----------------ICLAQNLVSDIE---------ALIR----LSVTSKKQSDPPWF------------------- -------------------------------------------------------------------------------- ----- >Oryzias_latipes_TSPAN5b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------MISGK HFKA-------------------------------HEVSCCIKYFIFGFN---IIFWFL--------------------G -VAFLGIGLWAWSEKGVL--SNISSITDLGG------FDPVWLF---LVVGGVMF-ILGFAGCIGALRENSFLLKFF--- -SVFLGIIFFLELTAG--VLAFVFKD---WIKDQLN-FFINNNIRAYRDDIDLQNL-----------------IDFTQEY --WECCG----------AFGADDWN----LNIYFNC--TDSNP------------SREKCGVPFSCCTKDPAED------ VINTQCGYDIR------------------AKTDSEQRTFIYIKGCVP-QFEKWLQDNLTVVAGIFIG---IALL---QVI L-----------------V------------------------------------------------------------- -------------------------------------------------------------------------------- ----- >Ciona_intestinalis_TSPAN5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----M-----------------------------PQEVGCCTKYFLFSFN---ILFWII--------------------G -LCLLGAGIWAWSEKGFF--DNLTAISSLP-------IDPVLVV---IIIALVMF-LLSFSGCLGSLRENIFLLKCF--- -SICLGVIFFAELIAG--ILGFVYKD---WFHQQFA-IFVNKTIKGYRDDPDLQNI-----------------IDFSQEY --LKCCGG---------DTGVADWDN----NIYFDCA-SNISFNDVF------LKPAESCGVPFSCCIKLGTSN------ VVNTQCGYGLRDPG----------------VTASEQVTKIYTSGCIT-QFGDWLKTNLYTVAGVFIG---VALI---QIV P-----------------ICFAQNLISDIQ---------AVKA----G-------------------------------- -------------------------------------------------------------------------------- ----- >Ciona_savignyi_TSPAN5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----M-----------------------------PHEIGCCTKYFLFSFN---ILFWII--------------------G -LCLLGAGIWAWSEKGFF--DNISVISSLP-------IDPVLVL---IIIALVMF-LLSFSGCLGSLRENIFLLKCF--- -SICLGVIFFAELIAG--ILGFVYKD---WFHQQFA-IFVNKTIKGYRDDPDLQNI-----------------IDFSQEY --LKCCGG---------DTGVSDWDN----NVYFSCT-SRIKFNDVF------LKPAESCGVPFSCCIKENAAD------ VVNTQCGYGLREDS----------------VTVAEQVTRIHTSGCIT-QFGDWLKTNLYTVAGAFIG---VALI---QII P-----------------ICFAQNLISDIQ---------AVKA----GWLEEKWSRLESMLKEESRLSNAERFTRTAYHP RSKTARSNSTVSPWYPVQCQEPQLTPVYCNVPHHNRMYVSVPDITMHRRQDSIHGAPVRRSWTSPSCVNVLMHCDDDGTL LEDYE >Branchiostoma_floridae_TSPAN5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------MRHITCNVNN----LS---SLLQLA--------------------G -GFILGIGLWAWFEKGTF--DNIAKVANVP-------VDPVLIF---VVVGAIMF-ILGFSGCVGALRENIILLRFF--- -SVVLGIIFFVELAVG--VLGFVYKD---WFRQQLD-NFIQANIIHYRDDPDLQNI-----------------IDFVQSY --FQCCG----------GEDYNDWEN----NIYFNCTLKESRG------------SREACGVPFSCCKDQGNNN------ VLNTQCGYDVREEE--------------INDIKLELDSMNPDQGCVP-QFEAWLQENLFVVAGVAIG---IALL---QVF G-----------------IYLANSLVSDIQ---------AIQA----LW------------------------------- -------------------------------------------------------------------------------- ----- >Caenorhabditis_elegans_TSPAN5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MANRRQPVQHRAQQR VYRQSQIRYAPG-------------------AGGESEISCCVKYSVFSFN---VIFFLL--------------------G -FGLLLFGVWAQIEKNTFV-NMLSKASKLY-------LDPTWPL---LIVGFLTF-IIGFSGCVGSLRENTSFLTFY--- -STLLGLLLIAEFSAG--VFAYACRD---QLDNYIR-NLLNDVVVGYRDDPDLQLL-----------------IDSMQET --WM-CCG---------INGADDWD----RNTYFSI--EAREVA-----------SPEAGGVPFSCCINSSKLE------ FKNYFCGHGVRLKPESHMAAHL------AAQRVMAHTASIYTEGCLP-KLQLWLNNNMLLVAVSMVI---IAII---QVL G-----------------ICFAQNLKSDIL---------AQRA----KWYYTH--------------------------- -------------------------------------------------------------------------------- ----- >Homo_sapiens_TSPAN17 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MPGK HQHFQ-----------------------------EPEVGCCGKYFLFGFN---IVFWVL--------------------G -ALFLAIGLWAWGEKGVL--SNISALTDLGG------LDPVWLF---VVVGGVMS-VLGFAGCIGALRENTFLLKFF--- -SVFLGLIFFLELATG--ILAFVFKD---WIRDQLN-LFINNNVKAYRDDIDLQNL-----------------IDFAQEY --WSCCG----------ARGPNDWN----LNIYFNC--TDLNP------------SRERCGVPFSCCVRDPAED------ VLNTQCGYDVR--LK-------------LVRGELEQQGFIHTKGCVG-QFEKWLQDNLIVVAGVFMG---IALL---QIF G-----------------ICLAQNLVSDIK---------AVKA----NWSKWNDDFENHWLTPTISEVLSTAGPQQNSLT GAPGPAPPSRHVFFGLGGLYPEPTFKNW---------------------------------------------------- ----- >Mus_musculus_TSPAN17 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MPGK HQQFQ-----------------------------DPEVGCCGKYFLFGFN---IVFWVL--------------------G -ALFLAIGLWAWGEKGVL--SNISALTDLGG------LDPVWLF---VVVGGVMS-VLGFAGCIGALRENTFLLKFF--- -SVFLGLIFFLELAAG--ILAFVFKD---WIRDQLN-LFINNNVKAYRDDLDLQNL-----------------IDFAQEY --WSCCG----------ARGPNDWN----LNIYFNC--TDLNP------------SRERCGVPFSCCVRDPAED------ VLNTQCGYDIR--LK-------------LVRRELEQQGSIYTKGCVG-QFEKWLQDNLIVVAGVLVG---IALL---QIF G-----------------LCLAQNLVSDIK---------AVKA----NW------------------------------- -------------------------------------------------------------------------------- ----- >Rattus_norvegicus_TSPAN17 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MPGK HQQFQ-----------------------------DPEVGCCGKYFLFGFN---IVFWVL--------------------G -ALFLAIGLWAWGEKGVL--SNISGLTDLGG------LDPVWLF---VVIGGIMS-VLGFAGCIGALRENTFLLKFF--- -SVFLGLIFFLELAAG--ILAFVFKD---WIRDQLN-LFINNNVKAYRDDIDLQNL-----------------IDFAQEY --WSCCG----------ARGPNDWN----LNIYFNC--TDLNP------------SRERCGVPFSCCVRDPAED------ VLNTQCGYDIR--LK-------------L---ELEQQGSIYTKGCVG-QFEKWLQDNLIVVAGVLVA---IALL---QIC G-----------------ICLAQNLVSDIE---------AVKA----NW------------------------------- -------------------------------------------------------------------------------- ----- >Anolis_carolinensis_TSPAN17 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MPGK AQHFQ-----------------------------GPQVSCCSKYLLFASN---VLFWLL--------------------G -AAFLAIGLWAWAEKGVL--SNLSSITDLGG------FDPVWLF---LVVGVVMF-VLGFAGCIGALRENTFLLKFF--- -SVFLGLIFFLELTAG--ILAFIFKD---WIKDQLN-FFINNNVKAYRDDIDLQNL-----------------IDFAQEY --WSCCG----------AHGPNDWN----LNIYFNC--TDSNP------------SRERCGVPFSCCVKDPAED------ VLNTQCGYDVR--LK-------------L---ELEQQSFIHTKGCAG-QFEKWVQDNLIVVAGTFVG---VALL---QIF G-----------------ICLAQNLVSDIN---------AVKA----NW------------------------------- -------------------------------------------------------------------------------- ----- >Xenopus_tropicalis_TSPAN17 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MSGK HQHFK-----------------------------GPEVSCCVKYFLFGFN---IVFWLL--------------------G -AAFLAIGLWAWAEKGVL--SNISSITDLGG------FDPVWLF---IVTGAVMF-VLGFAGCIGALRENTTLLKFF--- -SVFLGLIFFLELTAG--ILAFVFKD---WIKDQLN-FFINNNVKAYRDDIDLQNL-----------------IDFAQEY --WSCCG----------AHGPNDWN----LNIYFNC--TDSNP------------SRERCGVPFSCCVKDPAED------ VPNTQCGYDVR--LK-------------L---ELEQQSYIYTKGCVG-QFEKWLQDNLIVVAGVFVA---IALL---QIF G-----------------ICLAQNLVSDIK---------AVKA----NW------------------------------- -------------------------------------------------------------------------------- ----- >Tetraodon_nigroviridis_TSPAN17a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MSRK HHHFR-----------------------------GAEVSCCVKYFLFGFN---ILFWLL--------------------G -AAFLAIGLWAWKEKGVL--SNLSSITDLGG------FDPVWLF---IVVGGVMF-ILGFAGCIGALRENTFLLKFF--- -SVFLGLIFFLELTAG--ILAFVFKD---WIKDQLN-FFINNNVK-YRDDIDLQNL-----------------IDFAQDY --WSCCG----------AHGPDDWN----LNIYFNC--TDLNP------------SRERCGVPFSCCVKDPAED------ VINTQCGYDVR--HK-------------V---ELERQKHIYTKGCVG-QFEKWLQDNLIFVAGIFVG---IALL---QIF G-----------------ICLAQNLVSDVK---------AVKA----NW------------------------------- -------------------------------------------------------------------------------- ----- >Gasterosteus_aculeatus_TSPAN17b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MSRK HHHLK-----------------------------GAEVSCCVKYFLFGFN---ILFWLL--------------------G -AAFLAVGLWAWAEK-------------------------------------------------------------F--- -SVFLGLIFFLELTAG--VLAFVFKD---WLKDQLN-FFINNNVKAYRDDIDLQNL-----------------IDFAQEY --WSCCG----------AHGPDDWD----LNIYFNC--TEPNP------------SRERCGVPFSCCVKDPAED------ VINTQCGYDVR--LQ-------------K---ELDWQKYIHTKGCVG-QFEKWLQDNLIIVAGIFVG---VALL---QIF G-----------------ICLAQNLVSDVK---------AVKA----NW------------------------------- -------------------------------------------------------------------------------- ----- >Oryzias_latipes_TSPAN17a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MSRK RRHFK-----------------------------GTEVSCCVKYILFGFN---IIFWLL--------------------G -AAFLSIGLWAWAEKGVL--SNISSITDLGG------LDPVWLF---IVVGGVMF-ILGFAGCIGALRENTVLLKFF--- -SVFLGLIFFLELTTG--ILAYVFKD---WIKDQLN-LFINNNVKAYRDDIDLQNL-----------------IDFAQEY --WSCCG----------AHGPDDWN----LNMYFNC--TNSNP------------SRERCGVPFSCCVKDPAED------ VINTQCGYDVRRLTK-------------K---DLERQPFIHTKGCVG-QFEKWLQDNLILVAGIFVG---IALL---QIF G-----------------ICLAQNLVSDIK---------TVKA----NW------------------------------- -------------------------------------------------------------------------------- ----- >Homo_sapiens_TSPAN14 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MH YYRYS-----------------------------NAKVSCWYKYLLFSYN---IIFWLA--------------------G -VVFLGVGLWAWSEKGVL--SDLTKVTRMHG------IDPVVLV---LMVGVVMF-TLGFAGCVGALRENICLLNFF--- -CGTIVLIFFLELAVA--VLAFLFQD---WVRDRFR-EFFESNIKSYRDDIDLQNL-----------------IDSLQKA --NQCCG----------AYGPEDWD----LNVYFNC--SGASY------------SREKCGVPFSCCVPDPAQK------ VVNTQCGYDVRIQL------------------KSKWDESIFTKGCIQ-ALESWLPRNIYIVAGVFIA---ISL---LQIF G-----------------IFLARTLISDIE---------AVKA----GHHF----------------------------- -------------------------------------------------------------------------------- ----- >Mus_musculus_TSPAN14 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MH YYRYS-----------------------------NAEVSCWYKYLLFSYN---IVFWLA--------------------G -VVFLGVGLWAWSEKGVL--SDLTKVTRLHG------IDPVVLV---LMVGVVMF-TLGFAGCVGALRENICLLKFF--- -CGAIVLIFFLELAVA--VLAFLFQD---WVRDRFR-EFFESNIKSYRDDIDLQNL-----------------IDSLQKA --NQCCG----------AYGPEDWD----LNVYFNC--SGASY------------SREKCGVPFSCCVPDPAQK------ VVNTQCGYDVRIQL------------------KSKWDEFIFTKGCIQ-ALEGWLPRNIYIVAGVFIA---ISL---LQIF G-----------------IFLARTLISDIE---------AVKA----GHHF----------------------------- -------------------------------------------------------------------------------- ----- >Rattus_norvegicus_TSPAN14 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MH YYRYS-----------------------------NAEVSCWYKYLLFSYN---IVFWLA--------------------G -VVFLGVGLWAWSEKGVL--SDLTKVTRLHG------IDPVVLV---LMVGVVMF-TLGFAGCVGALRENICLLKFF--- -CGAIVLIFFLELAVA--VLAFLFQD---WVRDRFR-EFFESNIRSYRDDIDLQNL-----------------IDSLQKA --NQCCG----------AYGPEDWD----LNVYFNC--SGASY------------SREKCGVPFSCCVPDPAQK------ VVNTQCGYDVRIQL------------------KSKWDEFIFTKGCIQ-ALEGWLPRNIYIVAGVFIA---ISL---LQIF G-----------------IFLARTLISDIE---------AVKA----GHHF----------------------------- -------------------------------------------------------------------------------- ----- >Gallus_gallus_TSPAN14 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MH YYRYS-----------------------------NAEVSCWYKYLLFSYN---IVFWLA--------------------G -MAFLAAGLWAWSEKGVL--SDLTKVTGLHG------LDPVVLV---LVVGIVMF-TLGFAGCVGALRENICLLKFF--- -CGTIVLIFLLEVAVA--VLAVLFQD---WVRDKVK-EFFENNIKSYRDDIDLQNL-----------------IDSLQKI --NHCCG----------AQGPDDWD----FNIYFNC--SSESK------------SREKCGVPFSCCVPDPAQK------ VVNTQCGYDVRKKS------------------KSHWDDQIFIKGCIV-ALEAWLPRNIYVVAGVFIA---ISL---LQIF G-----------------IFLARTLISDIE---------AVKA----GNAF----------------------------- -------------------------------------------------------------------------------- ----- >Danio_rerio_TSPAN14a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MH YYRYE-----------------------------NAEVSCCYKYLMFSYN---IIFWLA--------------------G -SAFIAIGFWAWSEKGVL--SDLTQVTRLHG------FDPVWGV---LVVGTVTF-ILGFAGCVGALRENICLLKFF--- -SGVIGFIFFLELTAA--VLAFVFQG---QVREWIS-EFFLANVKAYRDDIDLQNL-----------------IDSLQKL --NHCCG----------AKHPNDWN----MNVYFNCS-NKNNL------------SREKCGVPFSCCISDPAVT------ VLNTQCGYDVREKGT-----------------LNDWSSSIYIKGCID-ALEDWLPRNLYIVAGVFIV---ISL---LQMV G-----------------IFLARTLIGDIE---------KVKF----NYY------------------------------ -------------------------------------------------------------------------------- ----- >Takifugu_rubripes_TSPAN14a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MY YYRYG-----------------------------TTEVSCCYKYLMFSYN---IIFWLA--------------------G -AAFIAIGFWAWSEKGIL--RDLTQVTQLHG------FDPVWLV---LLVGGVTF-TLGFAGCVGALRENICLLKFF--- -SGLIGLIFVLEMTVA--VLAIVFQS---QVREWIN-EFFIVNIRAYRDDIDLQNL-----------------IDSLQKM --NHCCG----------AQEPDDWN----QNVYFRC--NETHL------------SREKCGVPFSCCIPDPADT------ VVNTQCGYDIRKKL------------------KPDWEKHIYMKGCIA-ALEDWLPRNLYMLAVVFII---ISL---LQMV G-----------------IYLARTLISDIE---------KVKS----AFYSF---------------------------- -------------------------------------------------------------------------------- ----- >Tetraodon_nigroviridis_TSPAN14a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MY YYRYE-----------------------------NAEVSCCYKYLMFTYN---IIFWLA--------------------G -AAFIAIGFWAWSEKGIL--MDLTKVTQLHG------FDPVWLV---LLVGGITF-TLGFAGCVGALRENICLLKFF--- -TGLIGLIFILELTVA--VLAVVFQS---QVKEWFS-EFFLDNIRGYRDDSDLQNL-----------------IDSLQKM --NHCCG----------AREPDDWD----HNVYFGC--NETNL------------SRKKCGVPFSCCIFDPADT------ VVNSQCGYDVRKKP------------------KAEWANHIYTKGCIA-ALEDWLPRNLYTVAIVFVV---ISL---LQMV G-----------------IYLAKTLISDIE---------KVK-----ACDNF---------------------------- -------------------------------------------------------------------------------- ----- >Gasterosteus_aculeatus_TSPAN14a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MY YYRYE-----------------------------SAEVSCCYKYLMFSYN---IIFWLA--------------------G -VAFIAVGFWAWSEKGVL--LDLTQVTQLHG------FDPVWLV---LVVGGVTF-ILGFAGCVGALRENICLLKFF--- -SGVIGFIFLLELTAA--VLAVVFQS---QVREWIN-DFFLANVKGYRDDIDLQNL-----------------IDSLQRM --NHCCG----------AQGPNDWN----QNVYFSC--NGTHR------------SREKCGVPFSCCITDPADS------ VLNSQCGYDVRNRP------------------TSEWTEHIYTKGCIA-ALEDWLPGNLYTVAIVFIV---ISL---LQMV G-----------------IYLARTLISDIE---------KVNF----SY------------------------------- -------------------------------------------------------------------------------- ----- >Oryzias_latipes_TSPAN14a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------LKNAPHFPNMY YYRYE-----------------------------NSEVSCCYKYLMFSYN---IIFWLA--------------------G -AAFIAAGFWAWSEK------DLTQVTRLHG------FDPVWLV---LVVGGITF-ILGFAGCVGALRENICLLKFF--- -SGVIGLIFFLELTAA--VLAVVFQS---QVREWIN-DFFLQNIRSYRDDIDLQNL-----------------IDSLQKM --NQCCG----------AKDPNDWD----ENLYFNC--NMTNR------------SRESCGVPFSCCISDPTDL------ VINTQCGYDVRKK-------------------KDDWANYIHTKGCIT-ALEDWLPRNLYTVAIVFVV---ISL---LQMV G-----------------IYLAKTLISDIHKYCNLKIFSKKKR----RNYWY---------------------------- -------------------------------------------------------------------------------- ----- >Homo_sapiens_TSPAN15 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MPRGDSEQVRY CARFS---------------------------------YLWLKFSLIIYS---TVFWL---------------------I GALVLSVGIYAEVERQ--------KYKTLES----AFLAPAIIL---ILLGVVMF-MVSFIGVLASLRDNLYLLQAF--- -MYILGICLIMELIGG--VVALTFRN----QTIDFLNDNIRRGIENYYDDLDFKNI-----------------MDFVQKK --FKCCGG--------EDYRDWSKN------QYHDCS--APGP--------------LACGVPYTCCIRN-T-----TE- VVNTMCGYKTI------------------DKERFSVQDVIYVRGCTN-AVIIWFMDNYTIMAGILLG-ILLPQFLG---- ------------------VLLTLLYITRVE--------DIIMEHS-VTDGLLG-PGAKPSVEAAG--TGCCLCYPN---- -------------------------------------------------------------------------------- ----- >Mus_musculus_TSPAN15 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MPRGDSEQVRY CARFS---------------------------------YLWLKFSLIIYS---TVFWL---------------------I GGLVLSVGIYAEAERQ--------KYKTLES----AFLAPAIIL---ILLGVVMF-IVSFIGVLASLRDNLCLLQSF--- -MYILGICLVMELIGG--IVALIFRN----QTIDFLNDNIRRGIENYYDDLDFKNI-----------------MDFVQKK --FKCCGG--------EDYRDWSKN------QYHDCS--APGP--------------LACGVPYTCCIRN-T-----TD- VVNTMCGYKTI------------------DKERLNAQNIIHVRGCTN-AVLIWFMDNYTIMAGLLLG-ILLPQFLG---- ------------------VLLTLLYITRVE--------DIILEHS-VTDGLLG-PGAKSRTDTAG--TGCCLCYPD---- -------------------------------------------------------------------------------- ----- >Rattus_norvegicus_TSPAN15 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MPRGDSEQVRY CARFS---------------------------------YLSLKFSLIIYS---TVFWL---------------------I GGLVLSVGIYAEAERQ--------KYKTLES----AFLAPAIIL---ILLGVVMF-IVSFIGVLASLRDNLCLLQSF--- -MFILGLCLVMELIGG--IVALIFRN----QTIDFLNDNIRRGIENYYDDLDFKNI-----------------MDFVQKK --VTGAAGY-------EGQRGTSRT------LALDRV--LPIP--------------GHIPTPWLFCKRR-V-----TD- VVNTMCGYKTI------------------DKERLNAQNIIHVRGCTN-AVLIWFMDNYSIMAGLLLG-ILLPQFLG---- ------------------VLLTLLYITRVE--------DIILEHS-VTDGLLG-PGAKSSTDTAG--TGCCLCYPD---- -------------------------------------------------------------------------------- ----- >Gallus_gallus_TSPAN15 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MATGDAEQARY CARLS---------------------------------YLCLKFSLITYC---TAFWV---------------------I GGLVLAVGIYAEVERQ--------KYKTLES----AFLAPAIIL---ILLGIIMF-FVSFVGVLASLRDNLCLLQAF--- -MYILGLCLMIELAGA--VVALIFRN----QTIKFLNDNIRRGIENYYDDLDFKNI-----------------MDSVQKR --FKCCGG--------EDYTDWSKN------AYHDCA--APGP--------------LACGVPYTCCVRN-K-----TD- IINTMCGYKTI------------------DQERLSIQDVIYIRGCTN-AVLIWFLDNYSIMAGVLLG-ILLPQFLG---- ------------------VLLSLLYITRVE--------DIIAEHK-LGESLFGGTRQHPDPEFAS--PGCCMCYPG---- -------------------------------------------------------------------------------- ----- >Anolis_carolinensis_TSPAN15 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------RMAAGDSEQVRY CARFS---------------------------------YLCLKFSLVTYS---TVFWL---------------------L GAFVLAVGIYAEVERQ--------KYKTLES----AFLAPAIIL---ILLGIVMF-LVSFVGVLASLRDNLSLLQAF--- -MYILGICLLIELTGG--VMALIFRH----KTIDFVNDNIRRGIVNYYDDLDFKNI-----------------MDFVQEE --FKCCGG--------EDFKDWSIN------QYHACS--APGP--------------MACGVPYSCCITN-K-----TA- VINTMCGYNTI------------------DKERLSVQPFIHVRGCTN-AVLIWFLDNYAIMAGILLG-ILLPQFLG---- ------------------VVLTFLYISRVE--------DIITEHK-QNETLLDGGRQKMDVEFAG--AGCCMCFPA---- -------------------------------------------------------------------------------- ----- >Danio_rerio_TSPAN15a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------MTGEVRY CEKCS---------------------------------YFFLKFSLIGYA---TIFWL---------------------I GGFILAIGIYAEVERQ--------RYKTLEG----VFLAPAIIL---IVLGIIMF-IVSFIGVLASLRDNLCLLKVF--- -LYMLALCLVLELVGG--IVALIFKN----QTVDILNKNIRKGMVNYYDDLDFKNI-----------------MDFVQKT --FKCCGG--------TEYQDWEVN------MYHNCS--APGP--------------LACAAPYTCCIVT-P-----GE- VVNTMCGYKTL------------------NKERNENTNVIYIRGCTD-AVFIWLIDNYKTMAGLLLG-IFLPQFFG---- ------------------VIFTWLYITRVE--------DAIEEYGYYMDGLLQSDSVQPETKRQSKLAKCCKCMPLMD-- -------------------------------------------------------------------------------- ----- >Takifugu_rubripes_TSPAN15a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------NNGDIRY CHKFS---------------------------------YVFLKFLLFFYA---IVFWL---------------------I GGFILAVGIYAEVERQ--------RYKTLEG----VFLAPAIIL---ILLGVVMF-IVSFIGVLASLRDNLTLLKVF--- -MYTLAVCLILELLGG--VVALLFRN----QTVELLNKNIRKGIVNYYDDLDFKNI-----------------MDFVQQK --FKCCGG--------QEYKDWSVN------MYHNCS--APGP--------------LACGVPYTCCITTNP-----NE- VANSFCGYKVL------------------NKERLDLIEVIYTRGCTD-AFFIWLTDNYKIMAGLMLG-ILLPQFLG---- ------------------VIISWLYITRVE--------DAINEYGHYMDGLLSSSAGERTAKNHGRVAKWFKCMPDID-- -------------------------------------------------------------------------------- ----- >Tetraodon_nigroviridis_TSPAN15a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------SNGDIRY CHRFS---------------------------------YVFLKFLLFFYA---IVFWL---------------------I GGFILAVGIYAEVERQ--------RYKTLEG----VFLAPAIIL---ILLGIVMF-VVSFIGVLASLRDNLILLKVF--- -MYTLTICLILELLGG--VLALLFHN----QTVELLNKNIRKGIVNYYDDLDFKNI-----------------MDFVQKK --FKCCGG--------QEYKDWSVN------MYHNCS--APGP--------------LACGVPYTCCITNNP-----NA- VANTFCGYKVL------------------GKERLDLIEVIYTRGCTD-AVFIWLTDNYKTMAGLLLG-ILLPQFFG---- ------------------VIISWLYITRVE--------DAISEYGHYMDGLLDSGAGERAAKRHGRMAKWFKCMPDID-- -------------------------------------------------------------------------------- ----- >Tetraodon_nigroviridis_TSPAN15b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MP--SYTELRK TNHFY----------------------------------YFIKFTLNVYS---MLFSL---------------------V GLCVLCVGVYAEVERQ--------KNRTLEG----LFLAPAVVL---ILLGLVMF-TVSVVGMVGSLRDNKTLLHMF--- -LCVLCVLLLLQAVAL--TMALIFEK----KTSALFQSSIREGIKHYYDDLDFKNI-----------------LDYVQQK --FSCCGG--------DEYKDWGVN------QYHFCN--GTGP--------------LACGVPYTCCVRHKV-----GE- VINTLCGYQTL------------------DKARESLQDKIHVRGCIH-AVNLWMGDNIGITVALCCA-VGLPQLLG---- ------------------IILSCVFWNLLV--------DMSESPDMVDFKLKKAEVNYSELDLAG--AGWCMCLPRDGGY L------------------------------------------------------------------------------- ----- >Gasterosteus_aculeatus_TSPAN15a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MSDDDVRY CERCS---------------------------------YIFLKLILFAYA---IIWWL---------------------I GGFILAIGIYAEVERQ--------RYKTLEG----VFLAPAIIL---ILLGIIMF-IVSLVGLVGSLRDNLTLLKVF--- -MYTLAVCLILELLGG--ILALAFRH----QTVGLVNKNIRKGIVNYYDDLDFKNI-----------------MDFVQKR --FKCCGG--------QEYTDWSVN------MYHNCS--ALSP--------------SACGVPYTCCITTKP-----NE- VANTMCGYKVL------------------EKTRLELIEIIHIRGCTD-AFFIWLMDNYKIMAGLLLG-ILLPQFFG---- ------------------VVVSWLYMTRVE--------DAISEYGHYMD-LLDSSADERVHKEQPHVAKWFRCMPEI--- -------------------------------------------------------------------------------- ----- >Oryzias_latipes_TSPAN15b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MP--PYSELRK TNHFY----------------------------------FFIKFTLNIYS---MIFSL---------------------M GLCVLCVGVYAEVERQ--------KNRTLEG----LFLAPAVLL---ILLGLVMF-TVSVVGMVGSLRDNKTLLHMF--- -LCVLCVLLLLQAVGL--VMALIFEK----KTSALFQRSLREGIKHYYDDLDFKNI-----------------LDYVQQK --FSCCGG--------DEYKDWEVN------QYHFCN--GSGP--------------LACGVPYTCCVRGKV-----GE- VINTLCGYNTL------------------SQQRETLQEVIHVRGCIH-AVNLWMSDNIGITVALCCA-IGLPQLLG---- ------------------IILSCVFWNLLV--------DMSKSADMVDFKIKKAEFSYSELDLAG--AGWCLCLPRDGGY LPVPASEPDLDPIDVHLQKLKKQQPRSYSQLQKLQQSRSASGLDEVDVGR------------------------------ ----- >Branchiostoma_floridae_TSPAN15 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------MTYLEQLVS------------------------------ -AAIMGLGIFAEVVRR--------DLGSMNT----FLVSPAAAL---IAAGLVVF-VVTFLGMAGALRDNLILLKIF--- -IGLMITGLLLQLIVG--LVAFAFKD----QAKNFINEQVSKGVKSYFADLDFKNT-----------------MDWVQER --FYCCGG--------ADYEDWEKN------DYFRCA--SPGP--------------ASCGVPHTCCDRR---------- -------------------------------ARLELVDIVYIRGCTD-AVLIWFEDNFDIFAGLCIG-LLLPQLLG---- ------------------ILLSYIYINRIE--------DEIDQIKTAPYGTWG-GGDDTDAPAEK---DTAV-------- -------------------------------------------------------------------------------- ----- >Homo_sapiens_TSPAN33 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MARRPR-APAA SGEEFS------------------------------FVSPLVKYLLFFFN----MLFWV--------------------I SMVMVAVGVYARLMKH--------AEAALAC----LAVDPAILL---IVVGVLMF-LLTFCGCIGSLRENICLLQTF--- -SLCLTAVFLLQLAAG--ILGFVFSD----KARGKVSEIINNAIVHYRDDLDLQNL-----------------IDFGQKK --FSCCGG--------ISYKDWSQN------MYFNCSEDNPSR--------------ERCSVPYSCCLPTPD-----QA- VINTMCGQGMQ------------------AFDYLEASKVIYTNGCID-KLVNWIHSNLFLLGGVALG-LAIPQLVG---- ------------------ILLSQILVNQIK--------DQIKLQLYNQQHRADPWY------------------------ -------------------------------------------------------------------------------- ----- >Mus_musculus_TSPAN33 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MARRPG-VPAA YGDEFS------------------------------FVSPLVKYLLFFFN----MLFWV--------------------I SMVMVAVGVYARLMKH--------AEAALAC----LAVDPAILL---IVVGVLMF-LLTFCGCIGSLRENICLLQTF--- -SLCLTIVFLLQLAAG--ILGFVFSD----KARGKVSEIINNAIVHYRDDLDLQNL-----------------IDFGQKK --FSCCGG--------ISYRDWSQN------MYFNCSEDNPSR--------------ERCSVPYSCCLPTPN-----QA- VINTMCGQGMQ------------------ALDYLEASKVIYTNGCID-KLVNWIHSNLFLLGGVALG-LAIPQLVG---- ------------------ILLSQVLVNQIK--------DQIKLQLYNQQHRADPWY------------------------ -------------------------------------------------------------------------------- ----- >Rattus_norvegicus_TSPAN33 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MARRPG-VPAA YGEEFS------------------------------FVSPLVKYLLFFFN----MLFWV--------------------I SMVMVAVGVYARLMKH--------AEAALAC----LAVDPAILL---IVVGVLMF-LLTFCGCIGSLRENICLLQTF--- -SLCLTIVFLLQLAAG--ILGFVFSD----KARGKVSEIINNAIVHYRDDLDLQNL-----------------IDFGQKK --FSCCGG--------ISYRDWSQN------MYFNCSEDNPSR--------------ERCSVPYSCCLPTPN-----QA- VINTMCGQGMQ------------------ALDYLEASKVIYTNGCID-KLVNWIHSNLFLLGGVALG-LAIPQLVG---- ------------------ILLSQVLVNQIK--------DQIKLQLYNQQHRADPWY------------------------ -------------------------------------------------------------------------------- ----- >Xenopus_tropicalis_TSPAN33 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------LAMARRSP--GSG KEEDFS------------------------------FVSPVVKYLLFFFN----TLFWV--------------------I SMVMVGIGVYARLLKH--------AEAAMAC----LAVDPALLL---IGVGILMF-LITFCGCIGSLRENICLLQTF--- -AICLTLVFLLQLAVG--IVGFIFSD----KARGKVSEIISNAIEHYRDDLDLQNL-----------------IDFGQKE --FSCCGG--------ISYKDWSQN------MYFNCSSENRSR--------------ERCSVPYSCCLHDED-----EA- VINTLCGQGMQ------------------ELDYLEAGAFIHTNGCID-RLVNWLHSNLFLLGGVALG-LAIPQLVG---- ------------------ILLSQILINQIR--------DQIKLQRYNQQHKTDPWY------------------------ -------------------------------------------------------------------------------- ----- >Takifugu_rubripes_TSPAN33a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MGGKRRGAPERT YDEDFT------------------------------FVSPVVKYLLFIFN----FIFWV--------------------I SMVMVSIGVYARMMKQ--------AETALAC----LSVDPAIML---LVVGVLMF-IITFCGCVGSLRENICLLQTF--- -CISLTVIFLLQLVAG--ILGFVFAD----KARDKVTKIINKAITYYRDDIDLQNL-----------------IDFGQTE --FACCGG--------VAYTDWSSN------VYFNCSMQNPSR--------------ERCSVPFSCCVMTKITV-LEQM- VINTMCGQGMQ------------------ILEYSEAATYIYTNGCID-KLVNLIHSNMFLLGGIAMG-LAIPQLVG---- ------------------ILLSQILINQIK--------DQIELQRYNLKHRSDPWR------------------------ -------------------------------------------------------------------------------- ----- >Tetraodon_nigroviridis_TSPAN33a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------LFTHSVAMAERG -DEDYT------------------------------YVSRVVKYLLFLFN----FIFWL--------------------I SMVMVSIGVYARMIKH--------AETALAC----LTVDPAMML---LVVGILMF-IITFCGCVGSLRENICLLQTF--- -CICLTVIFLLQLIAG--ILGFIFAD----KARNKVTEIINNAITHYRDDIDLQNL-----------------IDFGQKE --FSCCGG--------VAFTDWSNN------MYFNCSKQNPST--------------ERCSVPFSCCIVTNT-----QM- VINTKCGQGMQ------------------LLEYTEAAASIHTNGCID-KLVNWIHSNMFLLGGIAMG-LAIPQLVG---- ------------------IFLSQTLINQIK--------DQIALQSYTLRHRSDPWS------------------------ -------------------------------------------------------------------------------- ----- >Tetraodon_nigroviridis_TSPAN33b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MDRKLN---LD RAETFS------------------------------FINPWIRYFLFFFS----FLFWI--------------------F SLLIVAIGVYAKVQKVT--------DTVRDT----FFVDPAVIL---IVVGVIMF-FITFCGCIGALRENIRLLKMF--- -SFSLTLVFLTQLAMA--ILGFFYSD----QTRDALGKFVRKAIVHYRDDLDLQNL-----------------MDYVQKE --FKCCGW--------NNYTDWSWN------LYFNCTPANPSS--------------ERCAVPYSCCTPIPG-----EA- VINTMCGFGVQ------------------TQNHLEANRSIYAVGCAD-KAVMWMESHLLLVGALALG-LALPQIAG---- ------------------IVLSQILISQIQ--------DEITLRLHRCEATARVCV------------------------ -------------------------------------------------------------------------------- ----- >Gasterosteus_aculeatus_TSPAN33a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MGGRG-GAPGSG --DDYS------------------------------FVSPVVKYLLFLFN----FIFWI--------------------C SLVMVAIGVFARLMKH--------AEAALAC----LAVDPAVML---MVVGFLMF-IITFCGCVGSLRENICLLQTF--- -CICLTVIFLLQLIAG--ILGFVFAD----KSRDRVTWMINNAIVHYREDIDLQNL-----------------IDFGQRE --FGCCGA--------VTYTDWSQN------MYFNCTQDNPSN--------------ERCSVPFSCCNLSED-----KV- VINTMCGAGMQ------------------HLEYIEAGDHIYTNGCID-KLVNWIHSNMFLLGGVALG-LAIPQLVG---- ------------------ILLSQILINQIK--------DQIALQNYNLKHRSDPWS------------------------ -------------------------------------------------------------------------------- ----- >Gasterosteus_aculeatus_TSPAN33b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -AKDFS------------------------------FVNPWIRYFLFFFS----FVFWV--------------------F SLLIVAVGVYAKIQKATGT----NIDAVRNT----FLIDPAVIL---IVVGVVMF-FITFCGCIGALRQNIRLLKTF--- -SLSLTLVFLTQLAIA--VLGFFYSE----QTRDALGKFVKKAVVHYRDDLDLQNL-----------------MDHIQKE --FQCCGW--------NNYTDWSWN------LYFNCTHENPSS--------------ERCAVPYSCCAPVPG-----ET- VINTMCGFGVQ------------------TMSHLEANKSIYAAGCMD-KAAMWIESHLLLVGALALG-TALPQIAG---- ------------------IVLSHILVSQIQ--------GIQHNTEQQGDGAYLRITPAHF-------------------- -------------------------------------------------------------------------------- ----- >Oryzias_latipes_TSPAN33a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------ITMGNGKDAAT SDAEFT------------------------------FVSPVVKYLLFVFN----FIFWV--------------------I SFVMVGIGVYARLIKQ--------AETALAC----LTVDPAVML---MVVGIFMF-IVTFCGCVGSLRENICLLQTF--- -CISLTVIFILQLTAG--IMGFIFSD----KARGKVTEVINKSIIHYRDDVDLQNL-----------------IDYGQKE --FRCCGG--------EAFTDWSQN------IYFNCSEKNPSR--------------ERCSVPFSCCIITKV-----KE- LFNSMCGEGMQ------------------KLDYITAGQYVYTDGCID-KLVNWIHSNLFIIGGIALG-LAIPQLVG---- ------------------ILLSQILINQIK--------DQIELQNYNARHRSDPWS------------------------ -------------------------------------------------------------------------------- ----- >Oryzias_latipes_TSPAN33b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------TMERELS---LN RAETFS------------------------------FVNPWIRYFLFFFS----FLFWV--------------------F SLLIVAIGVYAKVQKAT--------ETVRDR----FLVDPAVIL---IVVGVVMF-FITFCGCIGALRENIRLLKTF--- -SFSLTLVFLIHLAVA--ILGFFYSD----QTRSALEKFARKAIVHYRDDLDLQNL-----------------MDYIQKE --FKCCGW--------NSYTDWSWN------LYFNCTRENPSS--------------ERCAVPYSCCTPVPG-----ET- VINTMCGFGVQ------------------TQKYLDANKSIYPVGCAD-RAVMWIETHLLLVGALTLG-LALPQVTK---- ------------------THTSIEIIMGWP--------QGLRL------------------------------------- -------------------------------------------------------------------------------- ----- >Homo_sapiens_CD151 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MGEF-NEK KTTCG---------------------------------TVCLKYLLFTYN---CCFWLA--------------------G LA-VMAVGIWTLALKS-------DYISLLAS-------GTYLATAYILVVAGTVVMVTGVLGCCATFKERRNLLRL---- YFILLLIIFLLEIIAG--ILAYAYY---QQLNTELKENLKDTMTKR-YHQPGHEAV--------------TSAVDQLQQE F--HCCG----------SNNSQDWR----D-SEWIR-----------------SQEAGGRVVPDSCCKTV---------- --VALCGQRDHASNIYKVEG-----------------------GCIT-KLETFIQEHLRVIGAVGIG---IACV---QVF G-----------------MIFTCCLYRS-LKLE------HY--------------------------------------- -------------------------------------------------------------------------------- ----- >Macaca_mulatta_CD151 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MGEF-NEK KTTCG---------------------------------TVCLKYLLFTYN---CCFWLA--------------------G LA-VMAVGIWTLALKS-------DYISLLAS-------GTYLATAYILVVAGAVVMVTGVLGCCATFKERRNLLRL---- YFILLLIIFLLEIIAG--VLAYVYY---QQLNTELKENLKDTMAKR-YHQPGHQAV--------------TSAVDQLQQE F--HCCG----------SNNSQDWR----D-SEWIR-----------------SGEAGGRVVPDSCCKTV---------- --VAGCGQRDHASNIYKVEG-----------------------GCIT-KLETFIQEHLRVIGAVGTG---IACV---QVF G-----------------MIFTCCLYRS-LKLE------HY--------------------------------------- -------------------------------------------------------------------------------- ----- >Mus_musculus_CD151 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MGEF-NEK KATCG---------------------------------TVCLKYLLFTYN---CCFWLA--------------------G LA-VMAVGIWTLALKS-------DYISLLAS-------STYLATAYILVVAGVVVMVTGVLGCCATFKERRNLLRL---- YFILLLIIFLLEIIAG--ILAYVYY---QQLNTELKENLKDTMVKR-YHQSGHEGV--------------SSAVDKLQQE F--HCCG----------SNNSQDWQ----D-SEWIR-----------------SGEADSRVVPDSCCKTM---------- --VAGCGKRDHASNIYKVEG-----------------------GCIT-KLETFIQEHLRVIGAVGIG---IACV---QVF G-----------------MIFTCCLYRS-LKLE------HY--------------------------------------- -------------------------------------------------------------------------------- ----- >Rattus_norvegicus_CD151 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MGEF-NEK KATCG---------------------------------TVCLKYLLFTYN---CCFWLA--------------------G LA-VMAVGIWTLALKS-------DYISLLAS-------STYLATAYILVVAGVVVMVTGVLGCCATFKERRNLLRL---- YFILLLIIFLLEIIAG--ILAYVYY---QQLNTELKENLKDTMIKR-YHQSGHEGV--------------TNAVDKLQQE F--HCCG----------SNNSRDWR----D-SEWIR-----------------SGEADSRVVPDSCCKTV---------- --VTGCGKREHASNIYKVEG-----------------------GCIT-KLESFIQEHLRVIGAVGIG---IACV---QVF G-----------------MIFTCCLYRS-LKLE------HY--------------------------------------- -------------------------------------------------------------------------------- ----- >Gallus_gallus_CD151 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MREY-TEK KETCG---------------------------------TICLKYLLFIFN---FFFWLA--------------------G GA-VMAVGAWTLAKKS-------DYISLLSS-------STYSATAYILVVAGVVVMVTGILGCCATFKERRNLLRV---- YFILLLCIFLLEIIAG--ILAYIYY---QQLSTELKENLKNTMTEK-YRKEGEERV--------------TSAVDKLQQE F--KCCG----------SNNYTDWA----D-SMWIK-----------------SPEASGRKVPDSCCKTI---------- --TVLCGRRDHPSNIYK-EN-----------------------GCIT-KLENFIQEHLKIIGIVGIS---IACV---QIF G-----------------MIFTCCLYRS-LKQE------PY--------------------------------------- -------------------------------------------------------------------------------- ----- >Anolis_carolinensis_CD151 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MREY-SEN KETCG---------------------------------TICLKYLLFTFN---FFFWLA--------------------G GA-VMAVGIWTLAEKS-------DYISLLQS-------NTYMATAYILVVAGVVVMITGILGCCATFREQRSLLRA---- YFILLLCIFLLEIIAG--ILAYIYY---QQLNAELKQNLKETMTKK-YQKEGEEGV--------------TSAVDKLQQE F--KCCG----------SHNYTDWS----D-SDWIK-----------------SPEAKGRKVPDSCCKTI---------- --TTNCGTRDHPSNIYK-EG-----------------------GCIT-KLENFIQEHLKIIGAVGLG---IAFV---QIF G-----------------MIFTCCLYRS-LKSE------PY--------------------------------------- -------------------------------------------------------------------------------- ----- >Takifugu_rubripes_CD151a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MGAY-EEP KETCG---------------------------------TICLKYLLFAFN---FMFWLA--------------------G GV-VMAVGVWTLIEKT-------DYISLLPS-------MTYAASAYILVLAGVIVMVTGVLGCCATFKEHRKLLRV---- YFVLLLCIFLLEILAG--VLAYIYY---QQLNQELKQSLKETMTTK-YAQKGHDQV--------------TKAVDKLQQE F--KCCG----------SNGSSDWA----E-SIFIR-----------------SG-ANGRLVPDSCCKTS---------- --TELCGLRDHPSNIYKVEG-----------------------GCIS-KLEEFILDHLKIIGAVGVG---IACV---QII G-----------------MVFTCCLYRN-LKAE------PY--------------------------------------- -------------------------------------------------------------------------------- ----- >Tetraodon_nigroviridis_CD151a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MGAY-EEP KETCG---------------------------------TICLKYLLFAFN---FLFWLA--------------------G GV-VMAVGVWTLIEKT-------DYISLLPS-------KTYAASAYILVLAGVIVMVTGVLGCCATFKEHRRLLRV---- YFVLLLCIFLLEILAG--VLAYIYY---QQLNEELKQSLKETMTKK-YSQSGYDQV--------------TQAVDKLQQG F--KCCG----------SNGSSDWA----E-SLYIR-----------------SG-AEGRLVPDSCCKTP---------- --GQLCGLRDHPSNIYKVEG-----------------------GCIS-KLEQFTLDHLKIIGAVGVG---VACV---QIF G-----------------MVFTCCLYRN-LKAE------PY--------------------------------------- -------------------------------------------------------------------------------- ----- >Gasterosteus_aculeatus_CD151a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------MGVY-EEK KETCG---------------------------------TICLKYLLFSFN---FLFWLA--------------------G GG-VMAVGVWTLVEKS-------DYISLLSS-------KTYAASAYILVLAGAIVMVTGVLGCCATFKEQRKLLRVVQ-G YFVRLLCISLWEILSA--IRGYIYYQ--QQLNEELKQNLRETMTQK-YEQSSHEHV--------------TRAVDKLQQE F--KCCG----------SNSSSDWS----D-SVWIR-----------------SRDAAGRMVPDSCCKTR---------- --TDLCGRRDHPSNIYKVEG-----------------------GCIT-KLENFILDHLKIIGAVGVG---IACV---QVI G-----------------MVFTCCLYRS-LKAE------PY-