>Homo_sapiens_LEF1 ----------------------------------------------------------------------------MPQL SG-GGGGGGG--------------DPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE--------- ----SEIIPASNGHEVARQAQTSQEPYHDKAREHPDD---GKHPDGGLYNKGP--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------SYSSYSGYIMMPN----MNNDPYMSNGSLSPPIPRT---------------------- ------------------------------------SNKVPVVQPSHAV-HPLTPLITYSD-EHFSPGSHPSHIPSDV-- ---NSKQ-G------------------MSRHPPAPDIPTF----------------YPLSPGGVGQITPPLGWQGQ---- ------PVYPI---TGGFRQPYPSSLSVDTSMS----------RFSHHMIPG-PPGPHTTGIPHP--AIVTPQVKQEHPH TDSDLMHVK----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PQHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKLQESASG--------------------------------- ----------------------------------------------TGPRMTAAYI------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Macaca_mulatta_LEF1 ----------------------------------------------------------------------------MPQL SG-GGGGGGG--------------DPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE--------- ----SEIIPASNGHEVARQAQTSQEPYHDKAREHPDD---GKHPDGGLYNKGP--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------SYSSYSGYIMMPN----MNNDPYMSNGSLSPPIPRT---------------------- ------------------------------------SNKVPVVQPSHAV-HPLTPLITYSD-EHFSPGSHPSHIPSDV-- ---NSKQ-G------------------MSRHPPAPDIPTF----------------YPLSPGGVGQITPPLGWQGQ---- ------PVYPI---TGGFRQPYPSSLSVDTSMS----------RFSHHMIPG-PPGPHTTGIPHP--AIVTPQVKQEHPH TDSDLMHVK----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PQHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKLQESTSG--------------------------------- ----------------------------------------------TGPRMTAAYI------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Mus_musculus_LEF1 ----------------------------------------------------------------------------MPQL SGGGGGG-----------------DPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE--------- ----SEIIPASNGHEVVRQAPSSQEPYHDKAREHPDE---GKHPDGGLYNKGP--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------SYSSYSGYIMMPN----MNSDPYMSNGSLSPPIPRT---------------------- ------------------------------------SNKVPVVQPSHAV-HPLTPLITYSD-EHFSPGSHPSHIPSDV-- ---NSKQ-G------------------MSRHPPAPEIPTF----------------YPLSPGGVGQITPPIGWQGQ---- ------PVYPI---TGGFRQPYPSSLSGDTSMS----------RFSHHMIPG-PPGPHTTGIPHP--AIVTPQVKQEHPH TDSDLMHVK----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PQHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKLQESTSG--------------------------------- ----------------------------------------------TGPRMTAAYI------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Loxodonta_africana_LEF1 ----------------------------------------------------------------------------MPQL SG-GGGGGGG--------------DPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE--------- ----SEIIPASNGHEVARQAQTSQESYHDKAREHPDE---GKHPDGGLYNKGP--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------SYSGYSGYIMMPN----MNNDPYMSNGSLSPPIPRT---------------------- ------------------------------------SNKVPVVQPSHAV-HPLTPLITYSD-EHFSPGSHPSHIPSDV-- ---NSKQ-G------------------MPRHPPAPDIPTF----------------YPLSPGGVGQITPPLGWQGQ---- ------PVYPI---TGGFRQPYPSSLSVDTSMS----------RFSHHMIPG-PPGPHTTGIPHP--AIVTPQVKQEHPH TDSDLMHVK----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PQHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKLQESTSG--------------------------------- ----------------------------------------------TGPRMTAAYI------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Anolis_carolinensis_LEF1 ----------------------------------------------------------------------------MPQL SGGGGGGGGGGG----------GGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE--------- ----SETISSSNGHEVSRQGQ-PQEIYHDKGREHPEE---GKHTDGGLYGKGP--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------SYSGYSGYIMMPN----MNNDPYMSNGSLSPPIPRT---------------------- ------------------------------------SNKVPVVQPSHAV-HPLTPLITYSD-EHFSPGTHPSHLPSDV-- ---NSKQ-G------------------MSRHPPGPDMPTF----------------YPLSPGSVGQITPPLGWQGQ---- ------PVYPI---SSGFRQPYPSSLSVDTSMS----------RFSHHMIPG-PPGPHTTGIPHP--AIVTPQVKQEHPH TDSDLMHVK----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PQHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKLQESTSG--------------------------------- ----------------------------------------------AAPRMTAAYI------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Xenopus_tropicalis_LEF1 ----------------------------------------------------------------------------MPQL SGAGGGNGGGG-------------DPELCATDEMIPFKDEGDPQKEKIYAEISNPEEEGDLADIKSSLVNE--------- ----TEIIPSSNSHEISRRRQ---DSYHEKSREHPED---GKHPDGGLYSKGP--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------SYTGYPSYIMMPN----MNNEPYMSNGSLSPPIPRT---------------------- ------------------------------------SNKVPVVQPSHAI-HPLTPLITYSD-EHFAPGAHPSHIPSDV-- ---NSKQ-G------------------MHRHPQAPDLPTF----------------YPLSPGSVGQMTPPLGW------- --------------------------------------------YPHHMVSG-PPGPHATGIPHP--AIVNPQVKQEHPH NDNDLMHMK----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PHHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKLQESTSG--------------------------------- ----------------------------------------------VCAELHLLWV------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Takifugu_rubripes_LEF1a ----------------------------------------------------------------------------MEGG GGGGEGRGGGEGGGGGGGQGCGGGDPELCATDEMIPFKDEGDPHKEQIFAELSHSEEEGDLADIKSSLVNE--------- ----SESSPNSNSHDGVRQSQIP-DSYHEKHRDHQEDEERGKLQD--LYCKGH--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------PYSGYPSYSMMSN----MDAS-YMNNGSLSPPMPRTEVYIQTLWALLDMPSHGNGRD- ---------------------------TQRPPPDSISNKVPVVQPSHAV-HPLTPLITYSD-EHFAPGSHSGHHPHDG-- ---SNKQ-G------------------MPRQHPGPDMANF----------------YSLSPGGVGQITPPLGWLLQRRGR ---HPYDIQLY---HLLPFLPPICLCS-SCVSG----------LFSHHMVPG-PPGPHATGIPHP--AIVNPQIKHEPLH -ETDIMHMK----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PQHEQRKDQEPKKP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREK---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Tetraodon_nigroviridis_LEF1a ----------------------------------------------------------------------------MPQL SGGG-------------------GDPELCATDEMIPFKDEGDPHKEQIFAELSHSEEEGDLADIKSSLVNE--------- ----SESSPNSNSH-GVRQSQIP-DSYHEKHRDHQEDV--GKLQD--LYSKGH--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------PYSGYPSYSMMSN----MNDSSYMNNGSLSPPMPRTHLYTTHTHICVYNTHAHQIKSN YLQSGKWSTVKNQGGSLMSKQEQLSFRSPPHPHIPESNKVPVVQPSHAV-HPLTPLITYSD-EHFAPGSHSGHHPHDG-- ---SSKQ-G------------------MPRQHPGPDMPNF----------------YSLSPGGVGQITPPLGWFC----- ---FVFFPFFL---PNYRNFSPLFQLM-LTDIS----------TFSHHMVPG-PPGPHATGIPHP--AIVNPQIKHEPLH -ETDIMHMK----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PQHEQRKDQEPKKP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREK---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Gasterosteus_aculeatus_LEF1b ----------------------------------------------------------------------------MPQL SGGG-------------------GDPELCATDEMIPFKDEGDPHKEQIFAELSHSEEEGDLADIKSSLVNE--------- ----SESSPNSNSHDGARLSQIPQDSYHEKHRDHLED---GKLQD--LYSKGH--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------PYQGYPGYIMMSN----MNDS-YMNNGSLSPPMPRT---------------------- ------------------------------------SNKVPVVQPSHAV-HPLTPLITYSD-EHFAPGPHP-QDVNNK-- ---QACL-G------------------MQRHHQGPDMTNF----------------YSLSPGGVGQLTPPLGWF------ ---------------------------------------------SHHMVPG-PQGPHATGIPHP--AIVNPQVKHEPLH -ETDIMHMK----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PQHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRRKQWHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKMQESAPG--------------------------------- ----------------------------------------------TGQRMKTAYIS----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Oryzias_latipes_LEF1b ----------------------------------------------------------------------------MPQL SGGG------------------GGDPELCATDEMIPFKDEGDPHKEQIFAELSHSEEEGDLADIKSSLVNE--------- ----SESSPNSNNHDAARQSQIPPDSYHEKHRDLIEDE-RGKHAD--MYGKGH--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------VYPSYPGYIMMN-----MNSDSYMNNGSLSPPMPRTYNFFKWDYITVQTESVVTTQT- -----------------------LCDLHSESNSHLASNKVPVVQPSHAV-HPLTPLITYSD-EHFAPGSHSGLHPQDA-- ---NNKQ-G------------------MPRHHPGPDMPNF----------------YSLSPGGVGQITPPLGWLNTREGP ---KCDPTGCH---RKSLFSTSLQSLKNPLHSR----------MFSHHMVPG-PPGPHATGIPHP--AIVNPQIKHEPPH -ETDIMHIRK---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------PQHEQRKEQEPKKP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREK---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Branchiostoma_floridae_LEF1 ----------------------------------------------------------------------------MPQL NGSGGDDLGAG--------------------DETISFKDEGEQEEKSAENVSN------DLSDIKSSLANE--------- ------SESSQSGAVPSEGSKPPLQSYPREDSRRGDEG--SKAESVPVVSRGP--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------AYLTPGGVIVSNMG------VYPHPNGSLAASATSN---------------------- --------------------------------------KVSVVHGPPHP-GPLTQLMMYSN-EHFAPG-TPPHIGVPPNS IEVDPKTG-------------------IPRPRHPADLPPM----------------YAIPPNQLPQLGPSYPKIEEYHSQ ALWQSQGVYPIS--AAGYRHPYPTAIAVNATNMP----------RYPVLQHPHHPGMPPTGIPHP--AIVSP--HGMNLK HDPSQMHQK----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QDQKKEPEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALPREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKRDKQQGDTSEVSN------------------------------ ------------------------------------PKRCRARFGLDQQQAWCKPCR-------YGADEWR--------- ---------ESPILFCFC-LPVWN-------------------------------GGFKAQALP--NGSVV--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Homo_sapiens_TCF7 -----------------------------------------------------------------------MPQLDSGGG GAGGGDDLGAP--------------------DELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSLVNESEGAAGGAGIP GVPGAGAGAR-GEAEALGREHAAQRLFPDKLPEPLEDGLKAPECTS-GMYKETV-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------YSAFNLLMHYPP-----------PSGAGQHPQPQ----------------------- ----------------------------------------PPLH-KANQPPHGVPQLS-LY-EHFNSP-HPTPAPADI-- ---SQKQ--------------------VHRPLQTPDLSGF----------------YSLTSGSMGQLPHTVSW------- -------------------------------------------FTHPSLMLGSGVPGHPAAIPHP--AIVPPSGKQELQP FDRNLKTQA----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------ESKAEKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKRRSREKHQESTT---------------------------------- -------------------------------------DPGSPKKCRARFGLNQQT-DWCGPCRRKKKCIRYLPGEGRCPS PVPSDDSALGCPGSPAPQDSPSYHLLPRFPTELLTSPAEPAPTSPGLSTALSLPTPGPPQAPRSTLQSTQVQQQESQRQV A------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Macaca_mulatta_TCF7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------H-KANQPPHGVPQLS-LY-DHFNSP-HPTPAPADV-- ---SQKQ--------------------VHRPLQTPDLSGF----------------YSLTSGSMGQLPHTVSW------- -------------------------------------------FTHPSLMLGSSVPGHPAAIPHP--AIVPPSGKQELQS FDRNLKTQA----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------ESKAEKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKRRSREKHQESTT---------------------------------- -------------------------------------DPGSPKKCRARFGLNQQT-DWCGPCR----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Mus_musculus_TCF7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MYKETV-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------YSAFNLLMPYPP-----------ASGAGQHPQPQ----------------------- ----------------------------------------PPLHNKPGQPPHGVPQLSPLY-EHFSSP-HPTPAPADI-- ---SQKQG-------------------VHRPLQTPDLSGF----------------YSLTSGSMGQLPHTVSWPSPPLY- --------PLSP--SCGYRQHFPAPTAAPGA--------PYPRFTHPSLMLGSGVPGHPAAIPHP--AIVPSSGKQELQP YDRNLKTQA----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------EPKAEKEAKKP---VIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKRRSREKHQESTT---------------------------------- ------------------------------------------GGKRNAFGTYPEK-AAA-PAP-------FLP------- -----MTVL----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Canis_familiaris_TCF7 -----------------------------------------------------------------------MPQLDAGGG GA-GGGDLDAP--------------------EELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSRVNESEGAAGGAGVP GAGAGARGAAEVGAEALGREHASQRLFPDKLPESLEDGLKAPECAS-GMYKDTV-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------YSAFNLLMHYPP-----------PSGAGQHPQPQ----------------------- ----------------------------------------PPLHNKASQPAHSVPQLSPLY-EHFSSP-HPTSAPADI-- ---SQKQG-------------------VHRPLQTPDLSGF----------------YSLTSGSMGQLPHTVSWPSPPLY- --------PLSP--SCGYRQHFPAPTAAPGA--------PYPRFTHPSLMLGSGVPGHPAAIPHP--AIVPPSGKQELQP YDRSLKTQA----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------ESKVEKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKRRSREKHQESTT---------------------------------- ------------------------------------------GGKRNAFGTYPEK-AAA-PAP-------FLP------- -----MTVL----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Bos_taurus_TCF7 ------------------------------------------------------------------------PQLDSGGG GAGGGDDLGAP--------------------DELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSLVNESEGAAGDAGVP GAGAGARGEAEVGAEALGREHTSQRLFPDKLPESLEDGLKAPECTS-GMYKDTV-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------YSAFNLLMHYPP-----------PSGAGQHPQPQ----------------------- ----------------------------------------PPLHNKASQPSHGVPQLSPLY-DHFSSP-HPTPAPADI-- ---SQKQG-------------------VHRPLQTPDLSGF----------------YSLTSGSMGQLPHTVSWPSPPLY- --------PLSP--SCGYRQHFPAPTAAPGA--------PYPRFTHPPLMLGSGVPGHPAAIPHP--AIVPSSGKQELQP YDRSLKAQA----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------DSKAEKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKRRSREKHQESNS---------------------------------- ------------------------------------------GGKRNAFGTYPEK-AAA-PAP-------FLP------- -----MTVL----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Loxodonta_africana_TCF7 -----------------------------------------------------------------------MPQLDSGGG SAGGGDDLGAP--------------------DELLAFQDEGEEQD-KSRDSAAGPERDLAELKSSLVNESEGAAGGAGVP ---GTGAEAE-ARAEALGREHTSQRLFSDKLPESLEDGLKAPECVS-GMYKETV-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------YSAFNLLMHYPP-----------PSGAGQHPQPQ----------------------- ----------------------------------------PPLHNKASQPPHGVPQLSPLY-EHFSSP-HPTPAPADI-- ---NQKQ--------------------VHRPLQTPDLSGF----------------YSLTSGSMGQLPHTVSW------- -------------------------------------------FTHPSLMLGSGVPGHPAAIPHP--AIVPPSGKQELQP YDRSLKTQA----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------EAKVEKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKRRSREKHQESNT---------------------------------- -------------------------------------DPGSPKKCRARFGLNQQT-DWCGPCRRKKKCIRYLPGEGRCPS PVPSDDSALGCPGSPAPQDSPSYLLLPHLPTELLASPAEPAPTSPGLCATLSLPATGPQQAPRRTLQSTQVQPQESQR-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Gallus_gallus_TCF7 ----------------------------------------------------------------------------MPQL GSGGGDDLGAT--------------------DEMLAFKDEG--EQEEKIPENAFTERDLADLKSSLVNES---------- EGSGSPAAAADP-EAIRRVQD-PQRVYQEKLPDHMDDAG--MKHQDPGMYKGSA-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------YSGYPFLMLSDPY---------LPNGSMSPL-------------------------- -------------------------------------SNKVPVVQPSHGVHPLTPLIPYSN-DHFSHGSHSPHLPADI-- ---SQKQA-------------------VHRPSQTSDIPGF----------------YPLPPAGVGQITPSMG-------- ------------------------------------------WFTHPLML-GSGMH--TTGIPHP--AIVPHSGKQEMEH YDRN--MKP----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------QPEPKREKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKRRTREKQQDS------------------------------------ -----------------------------------NSDPASPKKCRARFGLNQQT-DWCGPCSFLQQFQLLSKYLFEFLK PL------------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Anolis_carolinensis_TCF7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------MSPL----------------SNKVPVGQ----------------------- -----------------------------------------PSH--GVHPLT--PLIPYSN-EHFSHGSHSPHLPADI-- ---SQKQG-------------------VHRPSQTSDIPGF----------------YSLPPTGVGQITSSMGW------- -------------------------------------------ITHP-LMLGSGM--HTTGISHP--GITSP-GKQEMDH YDRSMKSQP----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------EPKREKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKRRTREKQQDSNSG--------------------------------- -------------------------------------G------KRSAFGTYKED-AVP---------AQF--------- ---LPMEVL----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Danio_rerio_TCF7a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------V---PKHHDGGMYKAP--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------YSGYPFLMLPEPY---------LPNGPVSPS-------------------------- -------------------------------------SNKVSVVQQ--GMHPLTPLLPY---EHFNP--SPTHMPTDG-- ---GQKPG-------------------VHR-HQTQEISGF----------------YSLPQG---QITPSMN-------- ------------------------------------------WFSHSLML-QSGMH--PTGIPHP--AIVPPSGKQEHDQ FDRSIYNKS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------HAEAKREKEPKKP---VIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALTREEQA KYYELARKERQLHMQLYPSWSARDNYVSALGKKKRRKRDKQQDS------------------------------------ -----------------------------------STEPGSPKKCRARFGLNQQT-DWCGPCR----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Takifugu_rubripes_TCF7a ----------------------------------------------------------------------------MPQL SSGGGDDLGAN--------------------DEMIAFKDEG--EQEEKIQENALTERDLADLKSSLVNES---------- ETNQSPNAASTPPQAIRRAQQGEQRGFAEKHREHLDGV---SKHQDGGIYKTPT-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------YPGYPFLMLPDPY---------LPNGSVSPS-------------------------- -------------------------------------SNKVSVVQQSHGMHPLSSLLPYGN-EHFSP--SPPHLPADM-- ---SQKPG-------------------VHR-HQSQDLSGY----------------YSLPPGGVGQITPSMS-------- ------------------------------------------WFPHPLMLGPSGMH--PTGIPHP--AIVPPTGKQDHDQ YDRGMYLK------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QEVKQQKEPKKP---VIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALTREEQA KYYELARKERQLHMQLYPTWSARDNY----GKRKKRKREKLQDS------------------------------------ -----------------------------------GADPGSPKKCRARFGLNQQT-DWCGPCSSFATQKGQRNHFLSLFL SPL----------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Tetraodon_nigroviridis_TCF7b ----------------------------------------------------------------------------MPQL SSGGGDDLGAN--------------------DEMIAFKDEG--EQEEKIQENALTERDLADLKSSLVNES---------- ETNQSPNAA-----AIRRAQQGEQRSFAEKHRELIDGV---SKHQDGGMYKTPA-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------YTGYPFLMLPDPY---------LPNGSVSPSSRFPLICIWPLRMTAQAGHSRKRPVR IDVTGFSPVFVLQQ-----------------------SNKVSVVQQSHGMHPLSSLLPYGN-EHFSP--SPPHLPADM-- ---SQKPG-------------------VHR-HQSQDLSGY----------------YSLPPGGVGQISPSVSWLLVRQG- --------QAVY--PTLSPCGFRQPYASNLS----STPSSYSRFPHPLMLGPSGMH--PTGIPHP--AIVPPTGKQEHDQ YDRGMYLK------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------QEVKQQKEPKKP---VIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALTREEQA KYYELARKERQLHMQLYPTWSARDNY----GKKKEEKTGE---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Oryzias_latipes_TCF7b ----------------------------------------------------------------------------MPQL SSGGGDDLGAN--------------------DEMISFKDEG--EQEEKIQENAFTERDLADLKSSLVNES---------- EISQSPSAA-----AARRGHQGEQRGFPDKHREHLEGV---SKQQDGSMYKSAA-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------YPGYPFLMLPDPY---------LPNSSVSPSQRTYIKKKRWRIISKQQKMLQRRTGV LHLENPTSAHIVD------------------------SNKVSVVQQSHGMHPLTSLLPYSN-DHFSP--SPPHLPTDM-- ---SQKTG-------------------VHR-HQSQDLSGY----------------YSLPPGGVGQIPPSMSCFLPKQS- --------QPVY--PGLSPCGFRQSYSSNLPRNFLSSFLPGTRFPHSLMLGPSGMH--PTGIPHP--AIVPPSGKQEHDQ YDRGILLSPI---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------RKQQVETKREKEPKKP---VIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALTREEQA KYYELARKERQLHMQLYPTWSARDNY----GKKKRRKREKQQDSNTAHICTVQ--------------------------- ---------------------YPGVSLGITPGRSLRSDPGSPKKCRARFGLNQQT-DWCGPC---------RLKFLDVCP PSSEK--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Homo_sapiens_TCF7L2 ----------------------------------------------------------------------------MPQL NGGGGDDLGAN--------------------DELISFKDEGEQEEKSSENSSA----ERDLADVKS-------------- -SLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGP--PYPGYPFIMIPDLT---SPYLPNGS LSPTARTLHFQSGS------------------------------------------------------------------ -------------------------------------------------------------------------------- -------THYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVS---------------------- -------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLPADV-- ---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG- -----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHTLHTTGIPHP--AIVTPTVKQESSQ SDVGSLHSS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KHQDSKKEEEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKRDKQP-GETN-EHS----ECFLNPCLSLP-----PITDLSAPK KCRARFGLDQQNNWCGPCRRKKKCVRYIQG-EGSCLSPPSSDGSLLDSPPPSPNLL--GSPPRDAKSQTEQTQPLSLSLK P----DPLAHLSMMPPPPA--LL------LAEATHKASAL--------CPNGALDLP-PAALQP--AAPSSSIAQPSTSS LH-----SHSSLAGT-QPQPLSLVTKSLE--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Macaca_mulatta_TCF7L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------LHFQSGST---HYSAYKTI EHQIAV-------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------QYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVS---------------------- -------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLPADV-- ---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG- -----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHTLHTTGIPHP--AIVTPTVKQESSQ SDVGSLHSS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KHQDSKKEEEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKRDKQP-GETNEHS-----ECFLNPCLSLP-----PITDANTPK KCRALFGLDRQTLWCKPCRRKKKCVRYIQG-EGSCLSPPSSDGSLLDSPPPSPNLL--GSPPRDAKSQTEQTQPLSLSLK P----DPLAHLSMMPPPP--ALL------LAEATH-KAS-AL------CPNGALDLP-PTALQP-AAPS-SSVAQPSTSS LH-----SHSSLAGT-QPQPLSLVTKSLE--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Mus_musculus_TCF7L2 ----------------------------------------------------------------------------MPQL NGGGGDDLGAN--------------------DELISFKDEGEQEEKNSENSSA----ERDLADVKS-------------- -SLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGP--PYPGYPFIMIPDLT---SPYLPNGS LSPTAR-------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------TYLQMKWPLLDVQAGSLQSRQTLKDARSPSPAHIVS---------------------- -------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLPADV-- ---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG- -----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHTLHTTGIPHP--AIVTPTVKQESSQ SDVGSLHSS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KHQDSKKEEEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKRDKQP-GETNDLSAPK--KCRARFGLDQQNNWCGPCRDANTPK KCRALFGLDRQTLWCKPCRRKKKCVRYIQG-EGSCLSPPSSDGSLLDSPPPSPHLL--GSPPQDAKSQTEQTQPLSLSLK P----DPLAHLSMMPPPP--ALL------LAEAAHGKAS-AL------CPNGALDLP-PAALQPSMVPS-SSLAQPSTSS LH-----SHNSLAGT-QPQPLSLVTKSLE--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Gallus_gallus_TCF7L2 ----------------------------------------------------------------------------MPQL NGGGGDDLGAN--------------------DELISFKDEGEQEEKISENSSA----ERDLADVKS-------------- -SLVNESETNQNSSSDSEAERRPPPRSETFRDKSRESLEEAAKRQDGGLFKGP--PYPGYPFIMIPDLS---SPYLPNGS LSPTAR-------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------TYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVS---------------------- -------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLPADV-- ---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG- -----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHSLHTTGIPHP--AIVTPTVKQESSQ SDVGSLHSS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KHQDSKKEEEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKRDKQP-GETNEHS-----ECFLNPCLSLP-----PITDLSAPK KCRARFGLDQQNNWCGPCRRKKKCVRYIQG-EGSCVSPPSSDGSLLDSPPSSPAML--ASPSRDSKPQTEQTQPLSLSLK P----DPLAHLVMMPPPS--SLV------LAESAASKPG-ALPAAS--CPNGALDHA-PAALPP-----AASLAQPSTSS LH-----SHSSLAGP-QPQPLSLVTKSLE--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Anolis_carolinensis_TCF7L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MKWPLLDVQAGSLQSRQALKDARSPSPAHIVS---------------------- -------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLPADV-- ---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGAVGQIPHPLGWLVPQQG- -----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHSLHTTGIPHP--AIVTPTVKQESSQ NDVGSLHSS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KHQDSKKEEEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKRDKQP-GETNGKTQ----RMFLNPCLSLP-----PITDLSAPK KCRARFGLDQQNNWCGPCRRKKKCVRYIQG-EGSCVSPPSSDGSLLDSPPSSPNML--ASPTRDSKSQTEQTQPLSLTLK P----DPLAHLPLMPPASSSSVV------LTESSTSKPR-GLPASN--CQNGALDHQ-SATLQQ-SAPSSSSLVQPSTSS LH-----SHNSLAGT-QPQPLSLVTKSLE--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Xenopus_tropicalis_TCF7L2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------S---------------------- -------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLQADV-- ---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGAVGQIPHPLGWLVPQQG- -----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHSLHTTGIPHP--AIVTPTVKQESSQ SDMGSLHSS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KHQDSKKEEEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKQQ-GEANEHS-----ECYLNPCLSLP-----PITDLSAPK KCRARFGLDQQNNWCGPCRRKKKCIRYIQG-EGSCVSPPSSDGSLLDSPPSSPAMP--DSPASDSKPQTEQTQPLSLSLK P----DPLARI-CVPHSP-----------LAQSPARKPS-ALP--VTICQNGAEHAH-PHNVLQSSLPYGLSLTQPSTSF LP-----SHRSLAGTTQLQPLSLVTKPLE--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Danio_rerio_TCF7L2a ----------------------------------------------------------------------------MPQL NGGGGDDLGAN--------------------DEMISFKDEGEQEEKISENSSA----ERDLADVKS-------------- -SLVNESETNQNSSSDSEAERRPPPRSESFRDKTRESLEEAAKRQDGGLFKSP--PYPGYPFIMIPDLT---SPYLPNGS LSPTAR-------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------TYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVS---------------------- -------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLQADV-- ---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG- -----QPVYPIT--TGGFRHPYPTALTVNASMSS-----LLSSRFPPHMVPP-HHSLHTTGIPHP--AIVTPNVKQESSH SDIGSLNSS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KHQDAKKEEEKKKQP--HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKQA-GEGNEHR-----EYFPNPCLSLPP-----ITDLSAPK KCRARFGLDQQNNWCGPCRRKKKCIRYIQG-EGSCASPPSSDGSLLESPPSSPSMISPSPSSKESKPQTEQMQPLSLTMK PPPLLSSSQHQHLSMAPPPPLAL------LDNSGAG-KTSG------SAHNGSLDPSDVSSSRSTGS----ASSRP-ISA CH-----SHSLLPSSAPTQPLSLVTKSID--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Takifugu_rubripes_TCF7L2a ----------------------------------------------------------------------------MPQL NGGGGDDLGAN--------------------DEMISFKDEGEQEEKISENSSA----ERDLADVKS-------------- -SLVNESETNQNSSSDSEAERRPPPRSETFRDKTRESLEEAAKRQDGGLFKSP--PYPGYPFIMIPDLT---SPYLPNGS LSPTAR-------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------TYLQMKWPLLDVQPGGLQSRQALKDARSPSPAHIVS---------------------- -------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLQTDV-- ---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG- -----QPVYPIT--TGGFRHPYPTALTVNASMSS-----LLSSRFPPHMVPP-HHSLHTTGIPHP--AIVTPNVKQESTH SDINSLNSS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KQSDSKKEPEKKKEV--HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKRKKRKREKQQQAEGNEHR-----EYFPNPCLSLPPI--TAASDLSAPK KCRARFGLDQQNNWCGPCRRKKKCIRYIQG-EGSCASPPSTDGSLLDSPPSSPSSVVPSPSPKESKPQTEQMQPLSLTMK P--AHQPLHHPHLLAGPTPPLVQ------LENSAAASKTPGA-----SSHNGALEHVNVSSSRQRGSSVVPSMARPSASL CH-----SQSLLP----AQPLSLVTKSIE--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Tetraodon_nigroviridis_TCF7L2a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ILQSP------FTQILT-YFV---SPFS---- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------FLQ-------------------------------S---------------------- -------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLQTDV-- ---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG- -----QPVYPIT--TGGFRHPYPTALTVNASMSS-----LLSSRFPPHMVPP-HHSLHTTGIPHP--AIVTPNVKQESTH SDINSLNSS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KQSDSKKEPEKKKEV--HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKRKKRKREKQQQAEGN--------------------------------- -----------------GKRKKKCIRYIQG-EGSCASPPSTDGSLLDSPPSSPSSVVPSPSPKESKPQTEQMQPLSLTMK P--AHQPLHHPHLLAGPTPSLVQ------LENTAAASKTPGT-----SSHNGALEHGDVSSSRQRGSSVVPSMARPSASL CH-----SQSLLPT--APQPLSLVTKSIE--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Oryzias_latipes_TCF7L2a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------Q--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------S---------------------- -------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLQTDV-- ---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG- -----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHSLHTTGIPHP--AIVTPNVKQESSH SDISSLNSS----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KQSDAKKEEEKKKQV--HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA KYYELARKERQLHMQLYPGWSARDNY----GKRKKRKREKQQ-AESN--------------------------------- -----------------------------------ASDLS--------------------APKKCR-------------- ---ARFGLDQQNNWCGPCRC------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Strongylocentrotus_purpuratus_TCF7L2 ----------------------------------------------------------------------------MPQQ HSRGGEDDGPP--------------------DETKTYHTEGEQEEKASENVVGPRDSFDHLNDVKSSLIDEGE------- ----SVSQKGSSSQRNKRLSSGYGDHSKEDRHKKLHSVSDGSKLDHIARFTPYS-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------SLAFIANAGYPNGSMVGGPGITPKCGVPNVFPSPLRLGE---------------------- ------------------------------------GQKMPVLHPGAYPPSLAQLMMYQQEHYSHSPGTPPPHVRGLEV- ---DSKTG--------------------ILRRSHSEISPY----------------HPLSPSSLGTHPLEVYNMSWPGQ- ------PFYPLT--SSALRSPYPSSLAVSPASMAR-------LGPSPIGAGPIPVGSLPHFLMHP---IGSSQQHDAQQQ SNDRHQKEK----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------EKKLAAQEAKNKQQ---HIKKPLNAFMLYMKEMRASVVKECTLK--ESAAINQILGRR--WHALTREEQA KYYELARKERQLHMQLYPGWSARDNYAIH-GKKKKKKRDKSHGDNPG--------------------------------- -------------------------------------EPSTPKKCRARFGVDQQDFWCKPCRRKKKCIRYISSDENDHGR NDDDMDDDDSSLSRRKSWLKHGGTQH------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Homo_sapiens_TCF7L1 -------------------------------------------------------MPQLGGGGGGGGGG-SGGGGGSSAG AAGGGDDLGAN--------------------DELIPFQDEGGEEQEPSSDSASA---QRDLDEVKSSLVNESENQ----- -SSSSDSEA---ERR--PQPVR--DTFQKPRDYFAEV----RRPQDSAFFKGP--PYPGYPFLMIPDLS---SPYLSNGP LSPGGART------------------------------------------------------------------------ -------------------------------------------------------------------------------- -----------------------YLQMKWPLLDVP-----SSATVKDTRSPSPAHLSN---------------------- --------------------------------------KVPVVQHPHHM-HPLTPLITYSN-DHFSPGSPPTHLSPEI-- ---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLGWLVPQQG- -----QPMYSLP--PGGFRHPYP-ALAMNASMSS-----LVSSRFSPHMVAPAHPGLPTSGIPHP--AIVSPIVKQEPAP PSLSPAVSV----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KSPVTVKKEEEKKP---HVKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRK--WHNLSREEQA KYYELARKERQLHSQLYPTWSARDNY----GKKKKRKREKQLSQTQS--------QQQVQEAEG---------------- --------------ALASKSKKPCVQYLPP-EKPCDSPASSHGSMLDSPATPSAAL--ASPAAPAATHSEQAQPLSLTTK P----ETRAQLAL-HSAAFLSAK--------AAASSSGQMG-------SQPPLLSRPLPLGSMP--TALLASPP-SFPAT L------HAHQALPVLQAQPLSLVTKSAH--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Macaca_mulatta_TCF7L1 -------------------------------------------------------MPQLGGGGGGGGGGCSGGGSGSSAG AAGGGDDLGAN--------------------DELIPFQDEGSEEQEPSSDSASA---QRDLDEVKSSLVNESENQ----- -SSSSDSEA---ERR--PQPAR--DTFQKPRDYFADV----RRPQDSAFFKGP--PYPGYPFLMIPDLS---SPYLSNGP LSPGGART------------------------------------------------------------------------ -------------------------------------------------------------------------------- -----------------------YLQMKWPLLDVP-----SSATVKDTRSPSPAHLSN---------------------- --------------------------------------KVPVVQHPHHM-HPLTPLITYSN-DHFSPGSPPTHLSPEI-- ---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLGWLVPQQG- -----QPVYSLP--PGGFRHPYP-ALAMNASMSS-----LVSSRFSPHMVAPAHPGLPTSGIPHP--AIVSPIVKQEPAP PSLSPAVSA----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KSPVTVKKEEEKKP---HVKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRK--WHNLSREEQA KYYELARKERQLHSQLYPTWSARDNY----GKKKKRKREKQLSQTQS--------QQQVQEAEG---------------- --------------ALASKSKKPCVQYLPP-EKPCDSPASSHGSMLDSPATPSAAL--ASPAAPAATHSEQAQPLSLTTK P----ETRAQLAL-HSAAFLSAK--------AAASSSGQMG-------SQPPLLSRPLPLGSMP--TALLASPP-SFPAT L------HAHQALPVLQAQPLSLVTKSAH--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Mus_musculus_TCF7L1 -------------------------------------------------------MPQLGGGRGGGAG---GGGGGSGAG ATSGGDDLGAN--------------------DELIPFQDEGGEEQEPSSDSASA---QRDLDEVKSSLVNESENQ----- -SSSSDSEA---ERR--PQPAR--DAFQKPRDYFAEV----RRPQDGAFFKGP--AYPGYPFLMIPDLS---SPYLSNGP LSPGGART------------------------------------------------------------------------ -------------------------------------------------------------------------------- -----------------------YLQMKWPLLDVP-----SSATVKDTRSPSPAHLYGDPARW----------------- -----------------------------MVPPTFRSNKVPVVQHPHHM-HPLTPLITYSN-DHFSPASPPTHLSPEI-- ---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLGWLVPQQG- -----QPMYSLP--PGGFRHPYP-ALAMNASMSS-----LVSSRF-PHMVAPAHPGLPTSGIPHP--AIVSPIVKQEPAA PSLSPAVSA----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KSPVTVKKEEEKKP---HVKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRK--WHNLSREEQA KYYELARKERQLHAQLYPTWSARDNY----GKKKKRKREKQLSQTQS--------QQQIQEAEG---------------- --------------ALASKSKKPCIQYLPP-EKPCDSPASSHGSTLDSPATPSAAL--ASPAAPAATHSEQAQPLSLTTK P----EARAQLAL-HSAAFLSAK--------AAASNSSQMG-------SQPPLLSRPLPLGSMP--AALLTSPP-TFPAT L------HAHQALPVLQAQPLSLVTKSAH--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Rattus_norvegicus_TCF7L1 -------------------------------------------------------MPQLGGGRGGGAG---GGGGGSGAG ATSGGDDLGAN--------------------DELIPFQDEGGEEQEPSSDSASA---QRDLDEVKSSLVNESENQ----- -SSSSDSEA---ERR--PQPAR--DAFQKPRDYFAEV----RRPQDGAFFKGP--AYPGYPFLMIPDLS---SPYLSNGP LSPGGART------------------------------------------------------------------------ -------------------------------------------------------------------------------- -----------------------YLQMKWPLLDVP-----SSATVKDTRSPSPAHLS----------------------- -------------------------------------NKVPVLQHPHHLQHPLTPLITYSN-DHFSPASPPTHLSPEI-- ---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLGWLVPQQG- -----QPMYSLP--PGGFRHPYP-ALAMNASMSS-----LVSSRFSPHMVAPAHPGLPTSGIPHP--AIVSPIVKQEPAP PSLSPAVSA----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KSPVTVKKEEEKKP---HVKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRK--WHNLSREEQA KYYELARKERQLHAQLYPTWSARDNY----GKKKKRKREKQLSQTQS--------QQQIQEAEG---------------- --------------ALVSKSKKPCIQYLPP-EKPCDSPASSHGSTLDSPATPSAAL--ASPAAPAATHSEQAQPLSLTTK P----ETRAQLAL-HSAAFLSAK--------ATASNSSQMG-------SQPPLLSRPLPLGSMP--TALLTSPP-SFPAT L------HAHQTLPVLQAQPLSLVTKSAH--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Canis_familiaris_TCF7L1 ------------------------------------------------------------GGGGGGGGGGGGGGGGSGAG AAGGGDDLGAN--------------------DELIPFQDEGGEEQEPSSDSASA---QRDLDEVKSSLVNESENQ----- -SSSSDSEA---ERR--PQPAR--DAFQKPRDYFAEV----RRPQDGAFFKGP--PYPGYPFLMIPDLS---SPYLSNGP LSPGGART------------------------------------------------------------------------ -------------------------------------------------------------------------------- -----------------------YLQMKWPLLDVP-----SSTTVKDTRSPSPAHLSN---------------------- --------------------------------------KVPVVQPPHHM-HPLTPLITYSN-DHFSPGSPPTHLSPEI-- ---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLGWLVPQQG- -----QPMYSLP--PGGFRHPYP-ALAMNASMSS-----LVSSRFSPHMVAPAHPGLPTSGIPHP--AIVSPIVKQEPAP PSLSPAVSA----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KSPVTVKKEEEKKP---HVKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRK--WHNLSREEQA KYYELARKERQLHSQLYPTWSARDNY----GKKKKRKREKQLSQTQS--------QQQVQEAEG---------------- --------------ALASKSKKPCVQYLPP-EKSCDSPASSHGSMLDSPATPSAAL--ASPAAPAATHSEQAQPLSLTTK P----ESRAQLAL-HSAAFLSAK--------ATATSSGQMG-------SQPPLLSRPLPLGSLP--TALLTSPP-SFPAT L------HAHQALPVLQAQPLSLVTKSAH--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Bos_taurus_TCF7L1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------YLQMKWPLLDVP-----ASATVKDARSPSPAHLSN---------------------- --------------------------------------KVPVVQHPHHM-HPLTPLITYSN-DHFSPGSPPTHLSPEI-- ---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLSWLVPQQG- -----QPMYSLP--PGGFRHPYP-ALAMNASMSS-----LVSSRFSPHMVAPTHPGLPTSGIPHP--AIVSPIVKQEPAP PSLSPAVSA----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------KSPVTVKKEEEKKP---HVKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRK--WHNLSREEQA KYYELARKERQLHSQLYPTWSARDNY----GKKKKRKREKQLSQTQS-------QQQQVQETDG---------------- --------------ALASKSKKPCVQYLPP-EKPCDSPASSHGSMLDSPATPSAAL--ASPAAPAATHSEQAQPLSLTTK P----ETRAQLAL-HSAAFLSSK--------AAATSSGQMG-------SQPPLLSRPLPLGSVP--TALLTSPP-SFPAT L------HTHQALPVLQAQPLSLVTKSAH--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------- >Loxodonta_africana_TCF7L1 -------------------------------------------------------MPQLGGGGAGGGG----GGGGSGAG AAGGGDDLGAN--------------------DELIPFQDEGSEEQEPSSDSASA---QRDLDEVKSSLVNESENQ----- -SSSSDSEA---ERR--PQPAR--DAFQKPRDYFAEV----RRPQDGAFFKGP--PYPGYPFLMIPDLS---SPYLPNGP LSPGGART------------------------------------------------------------------------ -------------------------------------------------------------------------------- -----------------------YLQMKWPLLDVP-----SSSTVKDTRSPSPAHLVSLPSPWQ---------------- -----------------------------LFLSVFQSNKVPVVQHPHHM-HPLTPLITYSN-DHFSPGSPPTHLSPEI-- ---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLGWLVPQQG- -----QPMYSLP--PGSFRHSYP-ALAMNASMSS-----LVSSRFSPHMVAPAHPGLPTSGIPHP--AIVSPIVKQEPTP PSLSPAVSV--------------------------------------------------------------------