>Homo_sapiens_SYNPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MGTGDFICISMTGGAPWGFRLQGGK-EQKQPLQVAKIRNQSKASGSGLCEGDEVVSI NGNPCADLTYPEVIKLMESITDSLQMLIKRP---SSGISEALI------------------------------------- ------------------------------------------------------SENENKNLEHLTHGGYVESTTLQIRP ATKTQCTEFFLAPVKTEVPLAENQRSGPDCAGSLKEETGPSYQ-RAPQMPDSQRGRVAEELILREKVEAVQPGPVVELQL SLSQERHKGASGPLVALPG-AEKSKSPDPDPNLSHDRIVHINSIPTNEKADPFLRSSK---------------------- ---------------------------------IIQISSG-RELRVIQESEAGDAGLPRVEVILDCSDRQK--------- -----------------TEGCRLQAGKECVDSPVEGGQS----------------------------------------- ---EAPPSLVSFAVSSEGTEQGED--------------PRSEKDHSRPHKHRARHA------------------------ ------------------------------------------RLRRSESLSEKQVKEAKSKCKSIALLLTDAP-NPNSKG VLMFKKRRRRARKYTLVSYGTGELEREADEEEE---------------------------GDKEDTCEVAFLGASESEVD EELLS----DVDDN---TQVVNFDWD-SGLVDIEKKLNR-GDKM-EMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGG TP--------------------------SREQDAAQTDGLRTTTS----------------------------------- -----------------------YQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGTSETANIQRM------VPMN RTAKPFPGSVN------------------------QPATPFSPTRNMTSPIA----------DFPAPPPYSAVTPP-PDA F-------SRGVSSPIA-GPAQPPPWPQPAPWSQPA-----------------------------------FYDSSERIA S--------------RDER------------------------------------------------------------- -----------------------------ISVPAKRTGILQEAKRRSTTKPMFTFK---EPKVSPNPELLSLLQNSEG-- ------------------------------KRGTGAGGDSGPEEDYLSLGAEACNFMQSSS------------------- ---------------------------AKQKTPPPVAPKPAVKSS-SSQPVTPVS---------------PVWSPG---- --------VAPTQPPAFPTSNPS---KGTVVSSIKIAQPSYPPARPAS-TLNVAGPFKGPQAAVASQNYTPKP----TVS TPTVNAVQPGAVGPSNELP---GMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAA------RAQSP-------------TP SLPASWKYSSNVRAPPPVAYNPIHSPSYP--------------------LAALKSQP--SAAQPSKMGKKKGKK------ -----PLNALDVMKHQ--PYQLNASLFTFQPPD-AKDGLPQKSSVKVNS-----------------ALAMKQALPPRP-- VNAAS------PTNVQASSVYSVPAYTSPPSFFA-EASSPVSASPVP----------VGIPTSPKQESASSSYFVAPRPK FSAKKSGVTIQESGRSLSL-----------PGRSVPPPISTS-PWVYQPTYSYSSKPT-DGLEKANKRPTPWEAAAKSPL GLVDD----------AFQPRNIQESIVANVVSAARRKVLPGPPEDWNERLSYIPQTQKAY--MGSCGRQEYNVT--ANNN ----MSTTSQYGSQLPYAYYRQASRNDSAIMSMETRSDYCLPVADYNYNPHPRGWRRQT--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------- >Pan_troglodytes_SYNPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MGTGDFICISMTGGAPWGFRLQGGK-EQKQPLQVAKIRNQSKASGSGLCEGDEVVSI NGNPCADLTYPEVIKLMESITDSLQMLIKRP---SSGISEALI------------------------------------- ------------------------------------------------------SENENKNLEHLTHGGYVESTTLQIRP ATKTQCTEFFLDPVKTEVPLAENQRSGPDCAGSLKEETGPSYQ-RAPQMPDSQRGRVAEELILREKVEAVQPGPVVELQL SLSQERHKGASGPLVALPG-AEKSKSPDPDPNLSHDRIVHINSIPTNEKADPFLRSSK---------------------- ---------------------------------IIQISSG-RELRVIQESEAGDAGLPRVEVILDCSDRQK--------- -----------------TEGCRLQAGKECVDSPVEGGQS----------------------------------------- ---EAPPSLVSFAVSSEGTEQGED--------------PRSEKDHSRPHKHRARHA------------------------ ------------------------------------------RLRRSESLSEKQVKEAKSKCKSIALLLTDAP-NPNSKG VLMFKKRRRRARKYTLVSYGTGELEREADEEEE---------------------------GDKEDTCEVAFLGASESEVD EELLS----DVDDN---TQVVNFDWD-SGLVDIEKKLNR-GDKM-EMLPDTTGKGALMFAKRRERMDQITAQKEEDKVGG TP--------------------------NREQDAAQTDGLRTTTS----------------------------------- -----------------------YQRKEEESVRTQSSVSKSYIEVSHGLGHVPQQNGFSGASETANIQRM------VPMN RTAKPFPGSVN------------------------QPATPFSPTRNMTSPIA----------DFPAPPPYSAVTPP-PDA F-------SRGVSSPIA-GPAQPPPWPQPAPWSQPA-----------------------------------FYDSSERIA S--------------RDER------------------------------------------------------------- -----------------------------ISVPAKRTGILQEAKRRSTTKPMFTFK---EPKVSPNPELLSLLQNSEG-- ------------------------------KRGTGAGGDSGPEEDYLSLGAEACNFMQSSS------------------- ---------------------------AKQKTPPPVAPKPAVKSS-SSQPVTPVS---------------PVWSPG---- --------VAPTQPPAFPTSNPS---KGTVVSSIKIAQPSYPPARPAS-TLNVAGPFKGPQAAVASQNYTPKP----TVS TPTVNAVQPGAVGPSNELP---GMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAA------RAQSP-------------TP SLPASWKYSSNVRAPPPVAYNPIHSPSYP--------------------LAALKSQP--SAAQPSKTGKKKGKK------ -----PLNALDVMKHQ--PYQLNASLFTFQPPD-AKDGLPQKSSVKVNS-----------------ALAMKQALPPRP-- VNAAS------PTNVQASSVYSVPAYTSPPSFFA-EASSPVSASPVP----------VGIPTSPKQESASSSYFVAPRPK FSAKKSGVTIQESGRSLSL-----------PGRSVPPTISTS-PWVYQPTYSYPSKPT-DGLEKANKRPTPWEAAAKSPL GLVDD----------AFKPRNIQESIVANVVSAARRKVLPGPPEDWNERLSYIPQTQKAY--MSSCGRQEYNVT--ANN- ----MSTNSQYGSQLPYAYYRQASRNDSEIMSMETRSDYCLPVADYNYNPHPRGWRRQT--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------- >Mus_musculus_SYNPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MGTGDFICISMTGGAPWGFRLQGGK-EEQQPLQVAKIRSQSKASGSGLREGDEVVSI NGNPCADLTYPEVIKLMEGITDSLHLLVKRP---SSGTSETLD------------------------------------- ------------------------------------------------------SESETTNHQHLTHEGPMESTTLQIQQ ATETQSEDFFLAPVQTKVPLTEDQSNAWGYAECPKEEQ-------APPMLGSQEGHLVEEVILRQKAEAGQPGHVVELQL SLSKERHQCTSGPIVTLQG-NDKSTSPDPDWSSQLERTVHINSIPAPEKADTSLTS------------------------ -----------------------------------STSSG-RELRVIQGRDPGGAGLPQVEVILDCSDRLK--------- -----------------AEECRLQTGRGCVASPVEGGRS----------------------------------------- ---EAPPSLVSFAVSSEGTEHGED--------------QRSGKDQSRPHKHRARHA------------------------ ------------------------------------------RLRRSESLSEKQVKEAKSKCKSIALLLTDAP-NPNSKG VLMFKKRRRRARKYTLVSYGTGELEREEEEEEDQE---A---------------------GDKDEISEVAFLGTSESEVD EELLS----DVDDN---TQVVNFDWD-SGLVDIEKRLNR-GDKM-EMLPDTTGKGALMFAKRRERMEQFTAQNEEEKTGG MA--------------------------GGGPDALQTDGLRTMTS----------------------------------- -----------------------YQRKEE-SVRMQSSVSESSFQMGRSLASVPQQNGFSGVSETAGAQRM------FPMN RTAKPFLGSMN------------------------QPAAPFSPTRSVTSPIS----------DFPAPPPYSAVSPP-PEA F-------SRGVSSPVA-GPAQPPPWPQPAPWSQPA-----------------------------------FYDSSEQIA S--------------RDER------------------------------------------------------------- -----------------------------IAVPAKRTGILQEAKRRGTTKPMFTFK---ETKVSPNPELLSLLQNAEG-- ------------------------------KRGT--GGDSGPEEDYLSLGAEACNFMQSS-------------------- ---------------------------AKQKTPPPVAPKPAVKSPSSSQPVAPVS---------------PVWSPG---- --------VAPAQRPAFSTSNPPNPPQVTAVSSIKIAQPAAPPARPAS-ALNLAGPFKGPQAVVVSHNYTPKP----SAP TPLVNAAPAGAGGPSNELP---GMSGKGAQLFAKRQSRMEKYVVDSDTVQAHTV------RAQSP-------------TP SLPASWKYSSNVRAPPPVAYNPIHSPSYP--------------------LAAIKSQP--PGAQASKTSKKKGKK------ -----PLNTLDVMKHQ--PYQLNASLFTFQPPD-SKDGLPQKSTVKVSS-----------------APAMKQALPPRQ-- ANVGS------PTNAQASSVYSVPAYTSQPNFFAAEATSPVSASPVP----------VSVPTSPKQESTSTSYFVAPRPK FSAKKSGVTVQENGRSLSL-----------PGRSAPPIISAS-PWLYQSACNYSSKPT-FELEKANKRPTPWEAAARSPL GLVDD----------AFRPRNIQESIVAHVVSAARRKVSPGSQEDWKERLSFVPQTQKTN--MSFSERQEYPAPSPVNSH ----VSSHSLYSSQLPYVCYRQESRNDLKTMSMETRSEYCLPLGGYDYNPHPRGWRQQP--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------- >Rattus_norvegicus_SYNPO2 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MGTGDFICISMTGGAPWGFRLQGGK-EEKQPLQVAKIRSQSKASDSGLCVGDEVVSI NGNPCADLTYPEVIKLMESITDSLHLLIKRP---TSGTSEALD------------------------------------- ------------------------------------------------------SETENTNHQHLPHGGPMESTTLQIQH AAKTQGKDFLLASVQTSAPRTEDQGNAWGYAECTTEDQ-------VSQMPGSQEGHLVEEVILRKKPEAGQPGHVVELQL SLSKERQRCTSDPIVTLLG-NEKFKSPDPDWGTQHGRTVHINSIPAPEKADTSLTSGT---------------------- ---------------------------------TVQTSSG-RELTVIQGRDPGGTGLPQVEVILDCSDRLK--------- -----------------AEECRLQAGRGCVASPVEGGRS----------------------------------------- ---EAPPSLVSFAVSSEGTEQGED--------------QRSGKDQGRPHKHRARHA------------------------ ------------------------------------------RLRRSESLSEKQVKEAKSKCKSIALLLTDAP-NPNSKG VLMFKKRRRRARKYTLVSYGTGELEREEEEE-DQE---A---------------------GDKDEISDLAFLGTSESEVD EELLS----DVDDN---TQVVNFDWD-SGLVDIEKRLNR-GDKM-EMLPDTTGKGALMFAKRRERMEQFTAQNEEEKTGG LA--------------------------GGGSDALQTDGLRTMTS----------------------------------- -----------------------YQRKEE-SVRMQSSVSESSFQMGRSLGSVPQQNGFSGVSETAGPQRM------IPMN RTAKPFLGSVN------------------------QTAAPFSPTQSVTSPIP----------DFPAPPPYSAVSPP-PEA F-------SRGISSPVA-GPAQPPPWPQPAPWSQPA-----------------------------------FYDSSEQIA S--------------RDER------------------------------------------------------------- -----------------------------IAVPAKRTGILQEAKRRGTTKPMFTFK---ETKVSPNPELLSLLQNAEG-- ------------------------------KRGTGAGGDSGPEEDYLSLGAEACNFMQSS-------------------- ---------------------------AKQKTPPPVAPKPAVKTSSSSQPVAPVS---------------PVWSPG---- --------VAPAQGPAFSTTNPPNPPQVTAVSSIKIAQPTCPPARPAS-ALNLAGPFKGPQAAVVSHNYTPKP----SAP TPLVNAAPAGAGGPSNELP---GMSGKGAQLFAKRQSRMEKYVVDSDTVQAHTV------RAQSP-------------TP SLPASWKYSSNVRAPPPVAYNPIHSPSYP--------------------LAAIKSQP--PGAQASKTSKKKGKK------ -----PLNTLDVMKHQ--PYQLNASLFTFQPPD-SKDGLPQKSTVKVSSV----------------APAMKQALPPRQ-- ADIGS------PTNAKASSVYSVPAYTSQPNFFA-EATSPVSASPVP----------VSVPTSPKQETTSTSYFVAPRPK FSAKKSGVTVQENWRSLSL-----------PGRAAPPIMSAP-PWLCQPAYSYSSKPT-LEQEKANKRPTPWEAAAKSPL GLVDE----------AFRPRNIEESIVANVVSAARRKVFAGSQEDWKERLSFVPQTQKTS--MSFSERREYNVPSPVNSH ----VSSHSLYSSQLPYVCYRKESRNDLKAMSMDTRSEYCLPLGGYDYNPHPRGWRHQP--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------- >Loxodonta_africana_SYNPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------QIRSQSKASGSGLCEGDEVISI NGNPCADLTYPEVIKLMESITDSLQMLIKRP---SSGINETLI------------------------------------- ------------------------------------------------------SETENKNHEHLTHEGYVESTTLQIRP ATKTQYREFYVASVKSGVSLVEDEGNGLNCSGNIKEET------MAPQMPASQSGCMTDEVILREKAET---GPMVELQL SLSQEEPKATSAPQVAPLG-AEKSESPEADTNLQHDETVHINSVPTDEKGDP---------------------------- ---------------------------------FSEISSS-KELRVIPGREAGDPGLPRVEVILDCSDRQK--------- -----------------TEGCRLQAGKGYVDSSVEGGQS----------------------------------------- ---EAPPSLVFFAVSSEGTEQGED--------------PRSERDHSRPHKHRARHA------------------------ ------------------------------------------RLRRSESLSEKQVKEAKSKCKSIALLLTDAP-NPNSKG VLMFKKRRRRARKYTLVSYGTGELEREADEEEE---------------------------GDKEDTCEVAFLGTSESEVD EELLS----DADDN---TQVVNFDWD-SGLVDIEKKLNR-GDKM-EMLPDTTGKGALMFAKRRERMDQITAQKEEERVSG MP--------------------------RREPDAAQTDGVRTMTS----------------------------------- -----------------------YQRKEEESVRTQSSVSRSYIEVNQGLGNVPQQNGFSGAPETAEAQRM------IPMN RTAKPFPGSVN------------------------QPATPFSPARNVMSPTA----------DFPAPPPYSAVTPP-PEA F-------SRGVSSPTA-GPTQPPPWPQPAPWSQPA-----------------------------------FYDSSERIA S--------------RDER------------------------------------------------------------- -----------------------------IAVPAKRTGILQEAKRRSTTKPMFTFK---EPKVSPNPELLSLLQNSEG-- ------------------------------KRGTGAGGDSGPEEDYLSLGAEACNFMQGSS------------------- ---------------------------GKQKTPPPVAPKPAVKSS-SSQPVTPVS---------------PVWSPG---- --------VAPTQPPAFPVSNPS---QGTVVSSIKIAQPSYPPARSTS-AVHVAGPFKGPQAAVASQSVTPKP----TAP TPTVNTAHAGAVGPSNELP---GMSGKGAQLFAKRQSRMEKYVVDSDTVQARAA------RAQSP-------------TP SLPASWKYSSNVRAPPPVAYNPIHSPSYP--------------------LAAAKSQS--SAPQPS-TSKKKGKK------ -----PLNALEVMKHQ--PYQLNASLFTFQPPD-AKDGLPKKSAVKISS-----------------APALKQALPPRP-- VNASS------PTNVQPSSVYSVPAYSSQPTFFA-EATSPVSASPVP----------VAIPTSPKQESASSPYFVAPRPK FSAKKSGVAVQESGRSLSL-----------PGRSIPPTISTIPPWMFQPAYSYSSKST-DGLEKANKRLTPWEAAAKSPL GLVDD----------AFRPRNIQESIVANVVSAARRKVLSGPSESWKEKVSYVPQTQKAN--MSSSGRQEYSVTSLPDNS ----MSTNSQYGSQLQYAYYRQPSRNDSEIMSMETRSDYCLSVRDCNYNPHPRGWRRQT--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------- >Gallus_gallus_SYNPO2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------MSGGAPWGFRLQGGK-EQKQPLQIAKVRNKSKAAKAGLCEGDEVVSI NGKPCGDLTYAEVIVLMESLTDVLQMLIKRS---SSGINETFS------------------------------------- ------------------------------------------------------AEKENGKHDNIKNEDYRESTTLQINT AKEIPHGDLCIT-EIYSETHQGAGESNMHFSEKKQET--TQSHRITPKVIGTSKALVTDESAFRGKTEERRPSKMVELQL SLSNDGHKSTNAPAVTLIG-AEKCTPSGRGPSVQEDGTSPVIAIPLSVKEGNIQWSSK---------------------- ---------------------------------VVQFSSS-KEVKRIQS---AAPSIPRVEVILACSDREK--------- ------------------EGPTSLAERGCVDSQVEGGQS----------------------------------------- ---EAPPSLPSFAISSEGTEQGEDN-------------QHSERDH-RPLKHRARHA------------------------ ------------------------------------------RLRRSESLSEKQVKEAKSKCKSIALLLTAAP-NPNSKG VLMFKKRRQRARKYTLVSYGTGELERDEDEGEEGEVE-E---------------------GDKENTFEVSLLATSESEID EDFFS----DIDND---KKIVTFDWD-SGLLEVEKKTKS-GDEM-QTLPETTGKGALMFARRRQRMDQITAEQEEMKART MH-------------------------AEEQREVTVSENFQKVSSS---------------------------------- ----------------------AYQTKEEETLRQQPCISKSYADVSQNDGKTVQQNGFGLAPDTNLSFQSSEAQKAASLN RTAKPFPFGVQN-----------------------RAAAPFSPTRNVTSPLS----------DLPAPPPYCSISPP-PEA L-------YRPLSAPAA-SKAAPILWSH--------------------------------------------TEPTERIA S--------------RDER------------------------------------------------------------- -----------------------------IAVPAKRTGILQEAKRRSTSKPMFSFKE--APKVSPNPALLSLVHNAEG-- ------------------------------KKGSGAGFESGPEEDYLSLGAEACNFMQSQA------------------- ---------------------------SKQKAPPPIAPKPSLKVS--PAAGTPVS---------------PVWSP----- -------AVASNKAPSFPAPASP---QAAYPAAPKSPQYPHSPSANPPNTLNLSGPFKGPQATLASPN-HPAK----TPT TPS-----AGETKPPFEMPP--DMRGKGAQLFARRHSRMEKYVVDSETVQANMA------RASSP-------------TP SLPASWKYSSNVRAPPPVAYNPIHSPSYP--------------------PAATKPFP--KSTAATKNTKRKPKK------ -----GLNALDIMKHQ--PYQLDASLFTFQPPS-NKESLATKQIPKLPT-----------------SKQAMSFR---L-- PGSGS------PTNARASSVYSVPAYSSQPSFQS-NASTPVNESYTP----------TGYSAFSKPESTTSSLFTAPRPK FSAKKAGVIAQERSSGRSLSLPG-------KPSFISRATSPTSPLIFQPAPDYFSKPDTA-ADKPGKRLTPWEAAAKSPL GLVDE----------AFGPQNMQESIAANVVSAAHRKMLPEPPDEWKKKVSYDPPGPSAS--LALLGGKQPGVTAARKSS LS-VSNATTQAGSQQQYAYCSQRSQTDPDIMSMDSRSDYGLSTADSNYNPQPKGWRRPT--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------- >Danio_rerio_SYNPO2_a 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-------------------------------------------------------------------------------- ------------------------EGGNIEEAPTSSSVS----------------------------------------- ---FGLPS----------EEWDSE----------------SEREVYQPNKHRARHA------------------------ ------------------------------------------RLRRSESLSEKQVKEAKSKCKRIALLLSAPAPNPNNKG VLMFKKHRQRAKKYTLVSYGTGEDESDYKDEYDDSDK-------------------------EEHAVEFTVLATSEKEIG TDFFTN----ASAQ---KSIVSFDWD-TGLLEIERKLDN-QQDM-EALPETKGKGALMFAQRKQRMDEIVAEHEELRRKG IP----------------------------------VEAVQEPETHQ--------------------------------- ----------------------TYQHMEEHAYMH-AQETQNYMDVNL--------------------------------- -------------------------------------------HHSIVEQYS----------HQMNGMYDQQTQNEMQAS V-------ANRSAKPFSTQNRVAVPFSSPPNADNQEQSGY-------------------------------SLGQGEQIA S--------------RDER------------------------------------------------------------- -----------------------------ISVPAIKTGILQDTRRRNASKPMFTFKE--SPKVSPNPALLNLLNRN---- --------------------------------DKKAGFESCPEEDYLSLGAEACNFLQSPK------------------- ---------------------------MKHKTPPPVAPKPHINPASPPWTSPLMPHWAP----PPQQQPQPPWAQP---- --------QRQTQPQP-PWVSQA---KQQEPAQPPPAQP----IKQWSPP--------QPTPPRRINSYTTGTKVPSPVP ASSTVASH--GFGSAFEMP---ALKGKGAELFAKRQSRMEKYIVDSTTVQSNKA------RPSSP-------------SP SLPTSWKYSPNCRAPPPLAYNPIHSPSYP--------------------PGAVKQSP---SSSSSTANKNKSKD----KG KPAPKPLHVLDVMKHQ--PYQLNSSLFTYGPAAEKLAA--EKEAAEKLA-----------------AQKADQQAPSP--- ---PYQ-----QSSPPSYQAGPTPAYQTGPAMAYQ-QAPSSYVVPSYQ---------VAARA---DSASGSSVTAAPKPK FSAKKS-------------------------------------------------------------------------- --AAQ----------VWKPGTAEK-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------- >Danio_rerio_SYNPO2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- --------------------------------------------MEHLPQTKGKGVLMFAKRRQRMDEISAEHEEMRRKG IPVD-----------------------AIEETKREIVMPPPQESK----------------------------------- ------------------------QSPQDFYARQEKHYQGQPFQLQMLQQSANSMNGLDPHQGSAVPKPLVS-------N RTAKPFFSGHN------------------------QGQKTFSPVRGVSSPTS----------KKPENIFKVPIPVN---- --------------------TTPNVWSP----------------------------------------------TSDVIA S--------------RDER------------------------------------------------------------- -----------------------------IAIPAIKTGILPETKRRGANKTDLKER-----------------PLHQK-- ------------------------------KRDEKSLTEFVQEEDLLSLGAEACNFMQAPT------------------- ---------------------------VKQKNPPPVLPKPVINPAHPLWSADGHAVS------------TSLLMTS---- ---------SSAQAMGHNQVQAG--HTKQHPAAAWTPEPHQTPHKLRAGPSKSKTPWIKSQSEENSVASCPPQHLSTYLP ASKAPSASHQEYSSETGASEGLNLKGKGAELFARRQTRMEKFIVDNETVRTNKV------RPSSP-------------TL SMPSTWKYSSNIRAPPPVSYNPILSPFYP--------------------LAAVKQPPPATSPKTKPKVNKEKKN------ -PPPKHLNVLDVMKHQ--PYQLDSSLFTYNFTPEVEEAVSPKDSKPTSANSS------------SKISQTDKQNPSKATG EVSAVYPFVRQTTSNETAAVAPQQLDGKQLNMYDGTRNKGIFSVRLPPGSSGGNVSVGSSALENNQYASRSVLPVAPRPK FSAKKSN------------------------------------------------------------------------- -MTGK----------QWKPMILQH-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------- >Tetraodon_nigroviridis_SYNPO2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MGIGDYMCVTLRGGAPWGFTLKEGEGETYRPFLVSQVEEGGRASLAGVRDGDEMVSL NGEPCADLTLSQALEVMHTSADCLQLLFKR----YCTVSAEEE------------------------------------- ------------------------------------------------------EESEDMCSGQD-SEATLESTTLHIFS SDQRCQSPKELCMSEAQGEPYCG-LNSDEAVSK---LVCTELR--VSSPADQGG-----QEPDE--ERCFSPGEMVELQV SLSKQTSSDLGSTSLGSALGILGEPSGREAAEMVHKSTTGVLRLEPGALRNPLKQLGVV--------------------- ---------------------------------LSPPTVLGQGDGLVGHPARSE-------------------------- -----------------------------EGDPQSFSVS----------------------------------------- ---FGIPSDE----VTPAEEQDSD----------------SEGEQDKPHKHHARHA------------------------ ------------------------------------------RLRRCESLSEKQVKEAKSKCKRIALLLTAAPSNPNNKG VLMFKKHRQRAKKYTLVSYGTGEDEPES----------------------------------KRCTVELTLVATSHSEID KQFQTN----IHNS---KSVLAVSLD-KGLLEIERNLNN-REEM-ECLPETKGKGALMFAQRRQRMDEIAAEHEELRRHG IP----------------------------------VEGIQEAE------------------------------------ ------------------------KNLAENSYMQSTAESHIYMDVNA--------------------------------- ---------------------------------------QEYHQEQQMQHYS----------TNINGTVQQQTS-EMQHT F-------SNRTAKPFSVENMAAVPYSPAVSGCNQD-----------------------------------SFGQGEQIA S--------------RDER------------------------------------------------------------- -----------------------------IATPAIKTGVLMEGRKRNTGKPMFTFKE--CPKVSPNPALLNLLNKS---- --------------------------------DKKLGLESGPEEDYLSLGAEACNFLQSS-------------------- ---------------------------LKHKNPPPVAPKPVS-TQAQPSAQPEANVNPWAPP-SAQAQPQPPW--A---- --------QSSAERAQ----------QPAPANISTSLVNTRPSPKPWTPP----QTHTHPPPPQRMHSFTIGHRASSPIN PMATVLNP-SSQSPSLNMP---AVRGKGADMFVKRQSRMEKFVVDSETVEANKAS-----RSTSP-------------AA SLPNEWKYTPNVRAPPSRAYNPIQSPFYP--------------------PAATKQPP---SSSPSVKAKNKGKQ----KE TPP-KPLSVVDVMRHQ--PYQLSSSLFIFGPGTEANKSSAPKPAPSLPK-----------------PPAEDQAVRYEQMP RVQADG-----PYSQPA--CANSPPYLATPSVALQPQAPGSYVAPNVA---------VAAKA---ESVSGGN--AAPKPK FTAKKS-------------------------------------------------------------------------- --SAQ----------IWKPTAVDK-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------- >Gasterosteus_aculeatus_SYNPO2_a 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MGTGDYICVTLRGGAPWGFSLREGEGDTSRPFLVSQVEEGSRAFLAGVREGDEVVSL NGEPCANLLLSQAFTLIDTSIDCLQLLVKRSGLIYSTTPPGEA------------------------------------- ------------------------------------------------------ESEETDCGGRDSTDETLKSTTLHIFT ARHGSQSPR--------DEAYYGELGIDTEVPKGPKLLYTELH--VPSSGNGRGRGHDFQENDGEGLQRFSPGAVVEFQV SLSNQTLDDVGFTSLGSAHGIDGELSNKEAVEMIRPDTAS--HPVQCPLRQPLGQHGVV--------------------- ---------------------------------LGSPSKLGQVELILQQPAASGAGRGLPSVGGPGVGGSVG-------- -----------------SHSEGEEGGGQCEGVPGSFTVS----------------------------------------- ---FEIPSEE----ATAAEEHGSD----------------SEGDQDKPNKHRARHA------------------------ ------------------------------------------RLRRSESLSEKHVKEVKSKCKRIALLLTAAPPNPNNKG VLMFKKHRQRAKKYTLVSYGTGEDEPEYSDEEDEENEIE---------------------NQETHAVEFTLVAPNGSKID KHFLTN----AHST---KGVLTINWD-NSLLEIERKLNN-QAQM-ECLPETKGKGASMFAQRRQRMDEISAEHDELRRQG IP----------------------------------VEAVSVVK------------------------------------ ------------------------EKREDHSYTQSTTEGHAYMDVNT--------------------------------- -----------------------------------------HQQGQQQQNYQ----------QYQ----ERQYY-EQQQN Y-------N-RTAKPFSVENIPATPYSPAMSRANQD-----------------------------------IVSQGEQIA S--------------RDER------------------------------------------------------------- -----------------------------ISTPASRTGLLSDSRRRNAGKPMFTFKE--APKVSPNPALLNLLNRK---- --------------------------------DKK-GFESGPEEDYLSLGAEACNFLQSQQ------------------- ---------------------------IKHKTPPPVAPKPVINPNSPPWSPQPQ---------HQQQPSINAWPPS---- --------KTQDQVQP-PWIQAA---QPQPPAQPQAILN------PWLPVP----AQAQSPP-----SWAQQPRVSPPIN PMATVLNP-SSQGSAFEMP---AVRGKGADMFAKRQSRMEKFVVDSETVQANKTS-----RPESP-------------AA SLPNEWKYTPNVRAPPSRGYNPILSPSYP--------------------PAATKQPP---TSSPSTKANKKGKD------ -----PSSVLEVMKHQ--PYQLNASLLYFQPPGGPYQQAYNQQTYQQPA-----------------PPAYHPQAPHS--- PNPPYQ-----HAPQALYQPANSPPYLTPPSVSYQPQAPSVYVAPSFP---------IAARP---ESAAGGNTAAAPKPR FTAKKS-------------------------------------------------------------------------- --SAQ----------VWKPTAVDK-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------- >Oryzias_latipes_SYNPO2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MGTGDYVCVTLSGAAPWGFSLAEGEVDNQRSFLVSQVEQGGRAFLAGIQDGDVVVSI NGKPCADLTLLRASALIDTSTDSLQLCLKRN---VFIPAERLE------------------------------------- ------------------------------------------------------SE------GRSLSSEVLESTTLNIFS PDHRFQLPKELYISESRHEADFG-HSENDTDSPKTSQLCSVQQ--DTSSCENQG-----SNHEEGAEWSVSPGDILELQV SLSKQTLSDAGSTALGSAHGIEGEFSKREVIKALHKTTATSLCT-PCPVREPLGQHGVV--------------------- ---------------------------------VTPTSMLGQVEVILQQPAASGAGRGILSVGGPKVSESLG-------- -----------------SQSERQEGGGISEGVPGSFTIS----------------------------------------- ---FKTPSEE----AS-GEEQGSD----------------SEGDQEKPSKHHARHA------------------------ ------------------------------------------RLRRKDSISEKQLKEAKSKCKRIALLLTAAPSNPNNKG VLMFKKHRQRAKKYTLVSYGTGEDEQEYSDEEDEENGDI---------------------KQEIPAAEITFLATINSATD KTFIRD----ATSS---KCVLNFNLD-KALMDIEQNLQN-QAEM-ECLPETKGKGALMFAQRRLRMDEISAEHEELRRQG MP----------------------------------VEAVQETN------------------------------------ ------------------------KRAAELSFMQSATEGRTYMDVNN--------------------------------- -----------------------------------------LQEQKQMQQYP----------AIINGTNQQQAN-EIQSS F-------NNLSAKPFAAENMVATPYSHGASGTIQD-----------------------------------FAAQGEQIA S--------------RDER------------------------------------------------------------- -----------------------------ISTPAIKTSFLQDARRRNTGKPMFTFKE--APKMSPNPELLNLLNRS---- --------------------------------DKKLGFESGPEEDYLSLGAEACNFLQSQR------------------- ---------------------------VKPKIPPPVAPKPVINPNSPTPPQPQG----------------DTWAPA---- --------QTQLQTHVDSWTSQS---QQTSTNVSVSKINNRPSPKPWQPLQNTSQNLATPPPPRRMQSFTIGQRP-LPIN PMATVLNPKSSPGSAFEMP---VVKGKGADMFAKRQSRMEKFVVDSETVEANKAS-----RSTSP-------------AA SLPNEWKYTSNVRAPPPRAYNPIQSPLYP--------------------PAASKQPA---AASPSTKAKKKDQE----KQ TPAPKPLNVIDVMKHQ--PYQLDSSLFIFGPGAEAVKP--PISKPSPPN-----------------PPNENQPITLQ--P SNSPYS-----QPLQAAYQPANSPPYMAPPPVPYEQQSTSCYIAPSFP---------VVGRA---DSVSGGSNAAAPRPK FTANKS-------------------------------------------------------------------------- --SAQ----------VWKPAAAEK-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------- >Homo_sapiens_SYNPO -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MLGPHLPPPPLAPSEGRPTPCAFQIPDGSYRCLALEAEESSGEEGLQGEVGPTDL EEDEGVSRSGDDSACRVTQGTPQLPKALGIQPPSCSREEQGAS------------------------------------- ------------------------------------------------------QHDDRASQDWDVVKAGQMMTASPSPG P----GPRVAQKPALGRSTSLTEKDLKEAKARSQQIAAQLTTP-----------------------------PSSNSRGV QLFNRRRQRVNEFTLESHGQRGQ----KPSQESLRVLPSSLPGHAPGLSLSST--------------------------- -------------------------------------SLPEPGPPRHPSPQSPDRGVPGHSMEGYSEEAS---------- ---------------------LLRHLEKVASEE-EEVPL----------------------------------------- ---------------------------------------------VVYLKENAALLTAN--------------------- ------------------------------------------GLHLSQNREAQQSSPAPP-PAEVHSPAADVNQNLASPS ATLTTPTSNSSHNPP---ATDVNQNP-------------------------------------PATVVPQSLPLSSIQQN SSEAQLPSNGTGPASK-PSTLCAD-GQPQAPAEEVRCST---LLIDKVSTP-ATTTSTFSREATLIPSSRPPASDFMSSS LLI-------------------DIQPNTLVVSADQEMSGRAAATT----------------------------------- -------------------PTKVYSEVHFTLAKPPSVVNRTARPFGIQAPGGTSQMERSPMLERRHFGEKAPAPQPPSLP DRSPRPQRHIMSR-----------------------SPMVERRMMGQRSPAS-----------ERRPLGNFTAPPTYTET LS------TAPLASWVRSPPSYSVLYPSSDPKSSHLKG------------------------------------------ -------------------------------------------------------------------------------- -----------------------------QAVPASKTGILEESMARRGSRKSMFTFV-EKPKVTPNPDLLDLVQTADE-- ----------------------------KRRQ--RDQGEVGVEEEPFALGAEASNFQQEPAPRD---------------- --------------------------RASPAAAEEVVPEWASCLKSPRIQAKPKPK------------------------ -------------------------------------------------------------------------------- ----------------PNQNLSEASGKGAELYARRQSRMEKYVIESS-SHTPELARCP-----SP-------------TM SLPSSWKYPTNAPG------A-FRVASRS---------------------PARTPPASLYHGYLPENGVLR--------- ---------PEPTKQP--PYQLRPSLFVLSPIKEPAKVSPRAASP-----------------------AKPSSLDLVPN- --------------LP-KGALPPSPALPRPSRSSPGLYTSPGQDS-------------LQPTAVSPPYGGDISPVSPSRA WSPRAKQ--------------------------------------------------------------APRPSFSTRNA GIEAQ----------VWKPSFCFK-------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------