>Homo_sapiens_SPOCK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD KYWNRFRDDDYF---------------------------RNWNPNKPFDQ--ALDPSKDPCLKVKCSPHKVCVTQDYQTA -----------------------------LCVSRKHLLP--------------------------RQKKGNVAQKHWVGP SNLVKCKPCP--------------------------------VAQS---AMVCGSDGHSYTS------------------ -KCKLEFHACSTGKS-----------------------------LATLCDGP---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PEPEP--PKHKAER SA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSNTAQG- ---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDP-----------------------SEIN AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC VDKYG--NELAGSRKQGAVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEYE---RELGPKDKEGKLRVHTRAVTEDDEDEDD DKEDEVGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Gorilla_gorilla_SPOCK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD KYWNRFRDVSTG---------------------------ATR-PRGAGGL--LSLLCKTEALKVKCSPHKVCVTQDYQTA -----------------------------LCVSRKHLLP--------------------------RQKKGNVAHKHWVGP SNLVKCKPCP--------------------------------VAQS---AMVCGSDGHSYTS------------------ -KCKLEFHACSTGKS-----------------------------LTTLCDGP---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PEPEP--PKHKAER SA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSNTAQA- ---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDP-----------------------SEIN AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----KY----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Macaca_mulatta_SPOCK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD KYWNRFRDDDYF---------------------------RNWNPNKPFDQ--ALDPSKDPCLKVKCSPHKVCVTQDYQTA -----------------------------LCVSRKHLLP--------------------------RQKKGNVAHKHWVGP SNLVKCKPCP--------------------------------VAQS---AMVCGSDGHSYTS------------------ -KCKLEFHACSTGKS-----------------------------LTTLCDGP---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PEPEP--PKHKAER SA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSNTAQG- ---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC VDKYG--NELAGSRKQGAVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEDE---RELGPKDKEGKLRVHTRAVTEDDEDEDD DKEDEVGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Mus_musculus_SPOCK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MPAIAVLAAAAAAWCFLQVDSRHLDALAGGAALNNANFLDNDQWLSTVSQYDRD KYWNRFRDDDYF---------------------------RNWNPNKPFDQ--ALDPSKDPCLKVKCSPHKVCVTQDYQTA -----------------------------LCVSRKHLLP--------------------------RQKKGNVAHKHWLGP SNLVKCKPCP--------------------------------VAQS---AMVCGSDGHTYTS------------------ -KCKLEFHACSTGKS-----------------------------LNSLCDGP---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PEPEP--LKPKAEK SA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSDPAQG- ---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPA------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC VDKYG--NELAGSRKQGTVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEDE---RELGPKDKEGKLRVRTRAVREDDEDEDD DKEDEVGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Rattus_norvegicus_SPOCK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- AA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSDTTQG- ---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC VDKYG--NELAGSRKQGTVS-CEEEQ-ETSGDFGSGG-SVVLLDDLDDE---RELGPKDKEGKLRVHTRAVREDDEDEDD DKEDEVGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Canis_familiaris_SPOCK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------MVCGSDGHTYTS------------------ -KCKLEFHACSTGKS-----------------------------LNILCDGP---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PEPEP--SKHKTEK NA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSDGAQG- ---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC VDKYG--NELAGSRKQGTVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEDE---RELGPKDKLGKLRVHTRAVTEDDEDEDD DKEDEVGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Bos_taurus_SPOCK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -A---------------------CTDKELRNLASR---LKDWFGALHEDANRVINP---------------TSSETAQG- ---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC VDKYG--NELAGSRKQGAVN-CEEEQ-ETSGDFGSGG-SVVLLDDLEDE---QDLGPKDRLGKPRVHARAVTEDDEDEDD DKEDEVGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Equus_caballus_SPOCK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------MVCGSDGHTYTS------------------ -KCKLEFHACSTGKS-----------------------------LTTLCDGP---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PEPEP--PKHKAEK NA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSDTAQG- ---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC VDKYG--NELAGSRKQGTVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEDE---RELGPKDKLGKLRVHTRAVTEDDEDEDD DKEDEVGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Gallus_gallus_SPOCK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MVKCKPCP--------------------------------TVHAS---PVCGSDGHTYTT------------------ -KCKLEFHACTSGKT-----------------------------ITARCEGP---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PGPES--PKHKTEK TA---------------------CTDKELRSLASR---LKDWFGALHEDANRVIKP---------------TSSETAQG- ---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDP-----------------------SEIS AIYLDKY--EPCVKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPG------GLPCQNEMNRIQKLSR---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC VDKYG--NEIAGSRKQGTVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEEE---PEATKKDKEGKVKIHVRAANEDDEDEDD DKDDEIGYIWTSEWGEPRRALCIHTTQTACWWGRCCWLRFNCRKTLRNKFTFSSPL------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Taeniopygia_guttata_SPOCK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------AAWCFLQVESRHPEIITSNS--NHGNFLDNDKWLSTVSQYDKD KYWNKFRDDDYF---------------------------RNWNPNKPFDQ--ALDPSKDPCLKVKCSPHKVCVTHDYETA -----------------------------ICVSRKQLVH--------------------------RQKKGNLAQKHWAGA ANVAKCKPCP--------------------------------VAHS---SAVCGSDGHTYSS------------------ -QCKMEFHACTSGKT-----------------------------ITTRCEGP---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PGPES--LKHKTEK TA---------------------CTDKELRSLASR---LKDWFGALHEDANRVIKP---------------TSSETAQG- ---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDP-----------------------SEIS AIYLDKY--EPCVKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPG------GLPCQNEMNRIQKLSR---GKILFG-----VFIPRCNEEGYYKATQCHD-----STGQCWC VDKYG--NEIAGSRKRGTVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEEE---PEATKKDKEGKLKIHVRAANEDDEDEDD DKDDEIGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Pelodiscus_sinensis_SPOCK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -IRNGEIISLKL---------------------------LTLLFLHLFLI--ALDPSKDPCLKVKCSPHKVCVTHDYETA -----------------------------ICVSRKQLVHS------------------------LWQKKGNLAPKHWIGP ANLVKCKPCP--------------------------------GTHSS---PVCGSDGHTYSS------------------ -KCKLEFHACTSAKT-----------------------------IAARCEGP---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PGQES--PKHKAEK TA---------------------CTDKELRSLASR---LKDWFGALHEDANRVIKP---------------TSSDTAQG- ---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----VFLPRCNEEGYYKATQCHG-----STGQCWC VDKYG--NEIAGSRKQGTIS-CEEEQ-ETSGDFGSGG-SVVLLDDLEED---REGAKKDKEGKMKIHVRATNEDDEDEDD DKDDEIGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Takifugu_rubripes_SPOCK1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------DATKDPCLKVRCPAHRVCISHDVQTA -----------------------------ICTNRKQPAHS------------------------VKPRKGSTGHKHRLEA SAHGKCRLCS--------------------------------ALQS---SPVCGSDGHPYSS------------------ -KCKLEFQSCISGKS-----------------------------ISVKCAGL---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PGQELRNAAPKAER AGV------------------PCCENKELHSLAAR---LKDWFRILHLDTNRDLKSS--------------DNSDSTAG- ---------------------HFDTSILPICKDSLG-WMFNKLDMNFDLLLDQ-----------------------SELS ALYLDKY--ETCMKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPE------GLPCQTEKTRIQSQ-----RKTLIG-----SYIPRCTDEGYFKPTQCHG-----STGQCWC VDKYG--NEIAGSRKQGNPN-CDEEQ-ETSGDFGSGG-GVILLDDQEDE-PSQSGRSRQKKRRGRLHPRGTIEDDEDEDD DKDDETGYTW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Tetraodon_nigroviridis_SPOCK1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------DATKDPCLKVRCPPHRVCVSHDFQTA -----------------------------ICTNRKQPAHRY-----------------------VKPRKGSTGHKHRVEA GAHGKCRLCS--------------------------------VLQS---SPVCGSDGHSYSS------------------ -KCKLEFQSCISGKS-----------------------------ISVKCEGL---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PGRRAQNCS--AQR TG---------------------CTDSELHSLAAR---LKDWFRVLHLDANRDLKSS--------------DNFDSTTG- ---------------------HFDTSILPICKDSLG-WMFNKLDINFDLLLDQ-----------------------SELS ALYLDKY--EMCMKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPE------GLPCQSEKTRVQAQSQ---RKTLIG-----SYIPRCTDEGYFKSTQCHS-----STGQCWC VDKYG--NEIAGSRKQGNPN-CDEDQ-ETSGDFASGG-GVILLDDQEEE-PSQSGRSRQKKRRGRIHPRGTIEDDEDEED DKDDETGYTW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Gasterosteus_aculeatus_SPOCK1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------MLLFLLPAVALLLSRESTVSGSGTDKWLSTVAQY-KD RSWNRFRDDDYFKSWAPAKSLDQEREVEPGRQGDPGTKAHSGSAKKTAQD--GPDATKDPCLKVRCPPHKVCVSHDYQTA -----------------------------ICTNHKQPPHS------------------------VKPRKGGAGHKHRLEA GAHGKCRPCS--------------------------------GIQS---GPVCGSDGHTYSS------------------ -WCKLEFQSCLSGKT-----------------------------ISVKCDGP---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PGQQPSKPPHKTDK AG----------------------TDTQLHSLAAR---LKDWFGVLHLDANRDLKSS--------------DSFDSTAG- ---------------------HFDTSILPICKDSLG-WMFNKLDMNFDLLLDQ-----------------------SELS AIYLDKY--ELCMKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPE------GLPCQAEKSIIQNQSR---RKSLIG-----FYIPRCTEEGYYKPTQCHG-----STGQCWC VDKYG--NEIAGSRKQGNPN-CDEDQ-ETSGDFGSGG-AVILLDDQEEE-PSRSGRSRQNKRRGRIHPRGAIEDDEDEED DKDDEIGYVW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Oryzias_latipes_SPOCK1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------NDKWLGTGAQYNKD RSWNRFRDVSCVG----------------------TTQEKLQFFASFLAS--GPDTTKDPCLRLHCPPHKVCVSHDFQTA -----------------------------ICINQKQPGHR----------------------------KGSVNPKHRSEA GAHGKCRLCS--------------------------------ALKT---SPVCGSDGHSYSS------------------ -KCKLDFHGCMSGKA-----------------------------VSVKCKGL---------------------------- -CPCL--------------------------------------------------------------------------- ------------------------------------------------------------------PHYENIKSPHDTEK TS---------------------CTDAELHSLAAR---LKDWFGVLHLDANRDLKS---------------DSFDSTAG- ---------------------HFDTSILPICKDSLG-WMFNKLDMNFDLLLDH-----------------------SELS AIYLDKY--ELCMKP-----LFNSCD-SFKDG----------------------------------------------KL SNNEWCYCFQKPE------GLPCQSEKSRIQSQSH---RKSLVG-----SYVPRCTEEGYYKPTQCHS-----STGQCWC VDKYG--NEIAGSRKQGNPK-CDEDH-ETSGDFGSGD-AVLLLDDQEEE-PSQVGRSQQKKRRGR--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Ciona_intestinalis_SPOCK1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------MNVKTVILAVLVVGICTLCGTAEAKKRKRSQQAKLDLLPDEKLCARK -----------------------------RCGRKPKGSWC-----------------------------QVVRDENGHRT PTCVCPRSCN--------------------------------TTQIE---PVCSMYGRQYDS------------------ -ECLMHLEACKKRKN-----------------------------IKLAYEGP---------------------------- -CIAS--------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------QAKCQSHELQQFPFR---LLDWFVHLKDVDEFGSVDY----------------QKT---- ----------------------VMSLSETDRKDVAQ-WKFQHLDRNKDGKLSN-----------------------KEIK RFRFALMPLEHCAKH-----FFKKCDLDKN-----------------------------------------------RKL SSDEWSECLVTRALT----WYQGRNEVNR---------------------------EESIQ------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Homo_sapiens_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MRAPGCGR-LVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK IKHWNRFRDE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA -----------------------------MCISRKKLEH--------------------------RIKQPTVKLHGNKDS ----ICKPCH--------------------------------MAQLA---SVCGSDGHTYSS------------------ -VCKLEQQACLSSKQ-----------------------------LAVRCEGP---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------TEQAATSTAD-GKP ---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGSAS--------------SVAGPASG- ----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------TELA AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCDQ-----SSGDCWC VDQLG--LELTGTRTHGSPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA GEADDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Gorilla_gorilla_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------FSSCSVFHGL LLFPD--LQE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA -----------------------------MCISRKKLEH--------------------------RIKQPTVKLHGNKDS ----ICKPCH--------------------------------MAQLA---SVCGSDGHTYSS------------------ -VCKLEQQACLSSKQ-----------------------------LAVRCEGP---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------TEQAATSTAD-GKP ---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGSAS--------------SVASPASG- ----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------TELA AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCDQ-----SSGDCWC VDQLG--LELTGTRTHGSPDCD--DIVGFSGDFGSGVGC---------------------------------------EA GEADDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Macaca_mulatta_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MHAPGCGR-LVLPLLLLTAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK IKHWNRFRDE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA -----------------------------MCISRKKLEH--------------------------RIKQPTVKLHGNKDS ----ICKPCH--------------------------------MAQLA---SVCGSDGHTYSS------------------ -VCKLEQQACLSNKQ-----------------------------LAVRCDGP---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------TEQAATSTAD-GKP ---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGSAS--------------SAASPASG- ----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------TELA AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLAELERVQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCDQ-----SSGDCWC VDQLG--LELTGTRTHGSPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA GEADDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Mus_musculus_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MRAPGSGR-LALPLLLLAVVALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK IKHWNRFRD--E---------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCVAQGYQRA -----------------------------MCISRKKLEH--------------------------RIKQPSLKLHGGKDS ----VCKPCH--------------------------------MAQLA---SVCGSDGHTYSS------------------ -VCKLEQQACLSSKQ-----------------------------LAVRCEGP---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------TEQSTASTTD-SKS ---------------------ETCTGQDLADLGDR---LRDWFQLLRENSKQNGSAN--------------SATNPAG-- ----------------------LDKSLGASCKDSIG-WMFSKLDTSGDLFLDQ-----------------------TELA AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLAELERTQIQEA---AKKKPG-----VFIPSCDEDGYYRKMQCDQ-----SRGDCWC VDQLG--LELTGTRMHGTPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA GEADDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Rattus_norvegicus_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MRAPGSGR-LALPLLLLAVVALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK IKHWNRFRDVSS---------------------VDDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCVAQGYQRA -----------------------------MCISRKKLEH--------------------------RIKQPSLKLHGGKDS ----ICKPCH--------------------------------MAQLA---SVCGSDGHTYSS------------------ -VCKLEQQACLSNKH-----------------------------LAVRCEGP---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------TEQSTASTTD-SKS ---------------------ETCTGQDLADLGDR---LRDWFQLLRENSKQNGSAS--------------SSSSPAG-- ----------------------LDKSLGASCKDSIG-WMFSKLDTSGDLFLDQ-----------------------TELA AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLAELERTQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCDQ-----SSGDCWC VDQLG--LELTGTRMHGNPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA GEADDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Canis_familiaris_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MRAPGCGR-LVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDKQWLSSISQYSGK IKHGTRFRDE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA -----------------------------MCISRKKLEH--------------------------RIKQPTLKLPGNKDT ----ICKPCH--------------------------------MAPLA---SVCGSDGHTYSS------------------ -VCKLEQQACLSSKQ-----------------------------LTVRCEGP---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------TEQASLSTTD-GKP ---------------------ETCTGQDLADLGDR---LRDWFQLLHENAKQNGSAG--------------SGANLASG- ----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------TELA AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLAELERIQIQEA---SKKKPG-----IFIPSCDEDGYYRKLQCDQ-----SSGDCWC VDQLG--LELTGTRTHGSPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA GESDDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Bos_taurus_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MRARGCGR-LALPLLLLSAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK IKHWNRFRDE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA -----------------------------MCISRKKLEH--------------------------RIKQPAVKLHGNKDT ----ICKPCH--------------------------------MAHLA---SVCGSDGHTYSS------------------ -VCKLEQQACLSSKQ-----------------------------LTVRCEGP---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------TEQAATSTSD-SKP ---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGSAN--------------SGASPASG- ----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------TELA AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCDQ-----SSGDCWC VDQLG--LELTGTRTHGSPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEETE--EEEGEA GEADDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Equus_caballus_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MRAPGCGQ-LALPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK IKHWNRFRDE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA -----------------------------MCISRKKLEH--------------------------RIKQPTLKVHGNKDS ----VCKPCH--------------------------------MAQLT---SICGSDGHTYSS------------------ -VCKLEQQACLSSKQ-----------------------------LTVRCEGP---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------TEQAATSTAD-GKP ---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGSAS--------------SGASPASG- ----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------MELA AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCDQ-----SSGDCWC VDQLG--LELTGTRTHGSPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA GEADDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Loxodonta_africana_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MRAPSCGR-LALPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK IKHWNRFRDE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA -----------------------------MCISRKKLEH--------------------------RIKQPTLKLHGNKDT ----VCKPCH--------------------------------MAHLA---SVCGSDGHTYSS------------------ -VCKLEQQACLSSKQ-----------------------------LAVRCEGP---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------TEQAATSTTD-GKP ---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGSS---------------SGASPTTG- ----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------TELA AVNLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKRPG-----VFIPSCDEDGYYRKMQCDQ-----SSGDCWC VDQLG--LELTGSRMHGSPDCD--DIVGFSGDFGSGVGS----------------------------------------- GEADDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Monodelphis_domestica_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------MLPLGKLTSP----------------------------------- --------EE-----------------------VEDDYIKSWEDSQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA -----------------------------MCISRKKLEH--------------------------RIKQPALKLHENKEG ----FCKPCH--------------------------------MTQLA---SVCGSDGHTYSS------------------ -MCKLEQQACLTSKQ-----------------------------LTVKCEGQ---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------TEQAPASTTD-TKQ ---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGTAN--------------TGANPASG- ----------------------LDKSLGASCKDSIG-WMFSKLDTSNDLFLDQ-----------------------SELA AINLDKY--EICIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKKPG-----VFIPSCDEDGYYRKMQCDQ-----GSGDCWC VDQVG--QELTGTRLHGSPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA GEADDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Ornithorhynchus_anatinus_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------QDDYIKSWEDNQQGDEA--LDTTKDPCQNVKCSRHKVCIAQGYQRA -----------------------------MCISRKKLEH--------------------------RIKQPALKLHGNRES ----FCKPCH--------------------------------MTQLA---SVCGSDGHTYSS------------------ -VCKLEQQACLTSKQ-----------------------------LTVKCEGQ---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------TDHVPASTAD-GKQ ---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNSSAA--------------PLVRPANG- ----------------------LEKGLGASCKDSIG-WMFAKLDTSSDLFLDQ-----------------------AELA AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCNQ-----SSGECWC VDQLG--MELTGTRVHGNPDCD--DLVGFSGDFGSGVGWEDEEEKEAEE-----------------AGEEAE--EEEGEA GEADDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Anolis_carolinensis_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------MRAMPAPGCCSSCLVPMLLLLLSLAWPTRSKPGKEGESPGNFMEDEQWLSSISQYSGK IKHWNRFRD--------------------------DDYIKSWEDNQPVDEG--LDTTKDPCQKVKCSRHKVCIAQGYQRA -----------------------------MCISRKKLEH--------------------------RIKQPALKPHGNKDS ----LCKPCH--------------------------------MTQLA---SVCGSDGHTYSS------------------ -VCKLEQQGCLTNKQ-----------------------------LTVKCEGP---------------------------- -CPCA--------------------------------------------------------------------------- ------------------------------------------------------------------SDHSPTSATD-GKQ ---------------------ETCTGQDLADLGDR---LRDWFQLLHENAKQNSSGS--------------TGTNPVNV- ----------------------LDKSLVASCKDSIG-WMFSKLDTNSDLFLDQ-----------------------TELA AINLDKY--EICIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLVELERIQIQEA---AKKKPG-----AFIPSCDEDGYYRKMQCDS-----SSGECWC VDHLG--TELTGTRMHGNPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA GEADDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Xenopus_tropicalis_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------MWNPGGSCLILLPLLLPIAWAQGDG-----KEVENTGNFMEDEQWLSSINQYSGK IKHWNRFRD--------------------------DDYIKSWEDNQPGDEA--LDTTKDPCQKVKCSRHKVCIAHGYQKA -----------------------------MCISRKKLEH--------------------------RIKQPSMKIHGNRDS ----LCKPCH--------------------------------VTQPA---AVCGSDGHTYSS------------------ -VCKLEQQACLSSKQ-----------------------------LTVKCQGS---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------TEHTPTTTTETGKQ G--------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNNTSN--------------PGSKQVNV- ----------------------LDKSLVAGCKDSIG-WMFSKLDSNNDLFLDQ-----------------------AELA AINLDKY--EICIRP-----FFNSCD-TYKDG----------------------------------------------RV STAEWCFCFWREK-------PPCLVELEKVQIQEA---AKRKPG-----VFIPSCDEDGYYRKMQCDQ-----ASGECWC VDQHG--SELTGTRIHGNPDCD--DMVGFSGDFGSGVGWEDEEEKETED-----------------AGEEAE--EEEGET GEADDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Danio_rerio_SPOCK2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MVWMNNPGCVLVPLLMLVRVAMQVDVKSGKEAEKTGNFMEDEQWLSTISQYSRK IKHWNRFRD--------------------------DDYIRSWDENQGSNEN--VDTTKDPCQKVKCSRHKVCVAQGYQRA -----------------------------VCVNRKKLEH--------------------------RLK--QQVIRQQQES ----NCKPCP--------------------------------VSSSG---PVCGSDGHNYAS------------------ -QCKLEQQACLAGKE-----------------------------LKVRCPGL---------------------------- -CPCT--------------------------------------------------------------------------- ------------------------------------------------------------------ATTAPATD--VDGK H--------------------ESCTGQDLADLGDR---LRDWFQLLQGNGKQNSTG--------------SPAASSASI- ----------------------VDRTLVATCKDSIG-WMFSKLDTNSDLYLDQ-----------------------AELA AINLDKY--EVCIRP-----FFNSCD-SYRDG----------------------------------------------KV STAEWCLCFWREK-------PPCLAELERIQLQEG---AKKKS-----DTYIPSCDEDGFYRRLQCDK-----SRGECWC VDQHG--GELMGSRIHGNPDCD--EVVTYSGDFGSGLGWEDEEEKEAEE-----------------NGEEAE--EEEGEV GEVDDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Takifugu_rubripes_SPOCK2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------CSANMVAARLVASLCLLAGFSLQVDVKSAKEAGKAGNFMEDEQWLSTISQYSRK IKHWNRFRDE-----------------------VEDDYVKNGEENTASDET--VDTTKDPCQNVKCSRHKVCVAQGYQRA -----------------------------MCVNRRKLEQ--------------------------KVR--QSGQSEGHEG ----SCKSCP--------------------------------VTATS---PVCGSDGHNYAT------------------ -ECKLEQQACLTGKD-----------------------------LSVMCSGF---------------------------- -CPCA--------------------------------------------------------------------------- ------------------------------------------------------------------TS----TITEAKR- ---------------------DSCTGQDLADLGDR---LKDWFQLLHGNAKQNNSG--------------KLGSGTSSA- ----------------------LDRSLGASCKDSIG-WMFSKLDTNNDLYLDQ-----------------------SELT AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------KI SMAEWCLCFWRETE------PPCLAELERIQVQGA---AKMNP-----GMYIPSCDEDGYYRKVQCDQ-----SRGECWC VDQHG--GELMGSRIHGNPDCD--EVAGYSGDFGSGVGWEDEEEKEAED-----------------IGEEAE--EEEEEE GETDDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Takifugu_rubripes_SPOCK2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MVGITNIACLLIPLVMLADSAFQSDLKTVKEAEKTGNFMEDEQWLSTISQYSRK IKHWNRFRDE-----------------------VEDDYVRTWDENQGSNEN--VDTTKDPCQKIKCSQHKVCIAQGYQRA -----------------------------VCINRKKLEH--------------------------RLK--QPALRSPNG- ----NCQPCP--------------------------------ISSTG---PVCGSDGHNYAS------------------ -KCKLEQQACLTGKD-----------------------------LTLKCTGL---------------------------- -CPCT--------------------------------------------------------------------------- ------------------------------------------------------------------TAAPTPNS-SPLAS T--------------------ESCTGQDLADLGER---LRDWFQLLQTNAKQNNNSKRG---------ARTTAASTTSV- ----------------------LDRSLVASCKDSIG-WMFSKLDTNGDLYLDQ-----------------------AELA AINLDKY--EVCIRP-----FFNSCD-SYKDG----------------------------------------------KV STAEWCLCFWREKE------PPCLTELERIQILDG---GKRKY-----GRFIPSCDEDGFYRKLQCD-------RGECWC VDQNG--GEVAGTRTRGKTDCD--DEMAYSGDTGSAVGWEDEEEKEAEE-----------------TAEEAE--EEEGEV GEVDDGGYIW---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Tetraodon_nigroviridis_SPOCK2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MVEMTDLACLLVPLVMLADAAFQTDLKSVKEAEKTGNFMEDEQWLSTISQYSRK IKHWNRFRDE-----------------------VEDDYVRTWDENQGSDDN--VDTTKDPCQKIKCSRHKVCIAQGYQRA -----------------------------VCINRKKLEH--------------------------RQHSGQLVLHVQIAG LLMETVSPAP--------------------------------SPPWG---PVCGSDGHNYAS------------------ -KCKLEQQACLSGKD-----------------------------LTLRCAGL---------------------------- -CPCT--------------------------------------------------------------------------- ------------------------------------------------------------------TAAPTPKFFTPLAS T--------------------ESCTGQDLADLGER---LRDWFQLLQTNAKQSNNSKPG---------ARAAAASTTSV- ----------------------LDRSLVASCKDSIG-WMFSKLDTNGDLYLDQ-----------------------AELA AINLDKY--EVCIRP-----FFNSCD-SYKDG----------------------------------------------KV STAEWCLCFWREK-------PPCLTELERIQILDG---GKRKYV---QGQFISSCDEDGFYRKLQCD-------RGECWC VDQNG--GEVAGTRTRGKTDCD--DEMAYSGDTGS--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Tetraodon_nigroviridis_SPOCK2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------A--VDTTKDPCQNVKCSRHKVCVAQGYQRA -----------------------------MCVNRRKLEQ--------------------------KVQ--QPGQPEGHER ----SCKSCP--------------------------------VTVPS---PVCGSDGHNYAS------------------ -ECKLEQQACLTGKD-----------------------------LSVMCTGF---------------------------- -CPCA--------------------------------------------------------------------------- ------------------------------------------------------------------AS----TITESKRG GQSI---------------KRNSCTGQDLADLGDR---LKDWFQLLHGNAKQNNSG--------------RPGSGTSSA- ----------------------LDRSLGASCKDSIG-WMFSKLDTDSDLYLGQ-----------------------AELT AINLDKY--EICIRP-----FFNSCD-TYKDG----------------------------------------------KI SMAEWCLCFWRETE------PPCLAELEKIQVQGA---AKMNP-----GMYIPSCDEDGYYRKVQCHQ-----SRGECWC VDQHG--GELMGSRIHGNPECD--EVAGYSGDFGSG-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Gasterosteus_aculeatus_SPOCK2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------ATMVGITDIACLLVPLAVLAGSTFQTDVKGVKEAEKTGNFMEDEQWLSTISQYSRK IKHWNRFRDE-----------------------VEDDYVRTGEESQGSNDN--VDTTKDPCQKVKCSRHKVCVAQGDQKA -----------------------------VCVNRKKLEH--------------------------RLK--QPALRSPDG- ----NCQPCP--------------------------------ISSAG---PVCGSDGRSYAS------------------ -KCKLEQQACLIGKD-----------------------------LTLKCSGL---------------------------- -CPCA--------------------------------------------------------------------------- ------------------------------------------------------------------TAAPASTE--TIHA T--------------------EGCTGQDLADLGER---LRDWFQLLQGNAKQNNNSKTG---------ARTTAASSTSV- ----------------------LDRSLVASCKDSIG-WMFSKLDTNGDLYLDQ-----------------------AELA AINLDKY--EVCIRP-----FFNSCD-SYRDG----------------------------------------------KV STAEWCLCFWREK-------PPCLAVLERIQVLDG---GKRKF-----GRFIPSCDEDGFYRKQQCD-------RGECWC VDQNG--GKVAGSRMRGKPDCGTMMKMAYFSYFGQGVWDGKNEEKKGRQ--------------------GVE--EEEGEG EEVITGGPIG---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Gasterosteus_aculeatus_SPOCK2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------SYVCNYSGR LFSIHHLKLY-----------------------WKDDYIKNMEQNIGSDET--VDTTKDPCQNVKCSRHKVCVAQGYQRA -----------------------------MCVNRKKMEQ--------------------------RVK--QSGQPEARES ----GCKPCP--------------------------------VVSSSS--PVCGSDGHNYAS------------------ -QCKLEQQACLASKE-----------------------------LSAACAGF---------------------------- -CPCA--------------------------------------------------------------------------- ------------------------------------------------------------------TASVSLSNTDTKPP --------------------SESCTGQDLADLGDR---LRDWFQLLHVNAKQNNSG--------------KLRGDTASA- ----------------------LDKSLAASCKDSIG-WMFSRLDTNSDLYLDQ-----------------------AELT AINLDKY--EVCIRP-----FFNSCD-SYKDG----------------------------------------------KV STAEWCLCFWRE-K------PPCLAELERIQVQEA---AKKKP-----GVYIPSCDEDGYFRKVQCDQ-----SRGECWC VDQHG--GEMMGTRIHGNPDCD--EAAGYSGDLGSGVGW----------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Oryzias_latipes_SPOCK2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------VKCSQHKVCVAQGYQRA -----------------------------MCVSRKKLEH--------------------------RIK--QSEQLERHES ----NCAPCA--------------------------------EAASS---PVCGSDGHNYAS------------------ -QCKLELQACLTGKD-----------------------------LSIMCTGF---------------------------- -CPCV--------------------------------------------------------------------------- ------------------------------------------------------------------TS--SLSNSDTKR- --------------------AESCTGQDLADLGDR---LRDWFQLLHGNAKQNKSG--------------QPGTGTVSV- ----------------------LERSLIASCKDSIG-WMFSKLDTNSDLYLDQ-----------------------AELA AINLEKY--EVCIRP-----FFHSCD-SYKDG----------------------------------------------KV STAEWCLCFWRETE------PPCLAELERIQVQEA---AKKKP-----GIYIPSCDEDGYYRKVQCDQ-----SRGECWC VDQHG--GEIMGSRIHGNPDCD--EVAGYSGDFGSG-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Apis_mellifera_SPOCK2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MPFVSFSS----LQDDKSSQQQPLDSG----LSMQMKQDQQ--QMIPEKKKWI HDPSSDLCKPLNCK--------------------KKELCLLEDAYTAVCVSKKELHKNKEE--------IITKSKYFDEE EAKRKAEAEAAA---------------------AAAAAAAATG-LGGAVGSGVAGAADTGSMTLMAASGDSSTGSNANDG -----------------------------TSSGLEHEEREDD---ESSSQDDD-----------------VFYDSEKEED -----CKPCP--------------------------------VVKPT---YLCGSDNWTYSS------------------ -LCRLEYHNCIHTTE-----------------------------VKVNCMGF---------------------------- -CPCK----GKRWQ----------------QQQQQQQLK----------------------------------------E EKNRHYNHINSQYTFTPEEIKYDNKHYKYIKYTTYKGKYDGYGSSGSGSTRMTGEDKHKIRGYNEVLDKPASTSNNNGNS KPSKLSGS----------SARNECKPQQLTAIGNR---LLDWFSVIMADSKKRRQHQQQ--------------------- ---------------------KNKVHFPAACKLEAR-WMFGHLDLNNDGELST-----------------------QELY DLEHDQN--ERCIKP-----FIDTCD-LDQDN----------------------------------------------TI DPREWCRCFEKTDR-------PCAAVRRRLGNDLSG-------------SYAPDCDSQGFYKPTQCHQ-----AVGVCWC VDEHG--VEFANTRTRG-KPNCEEIINNATT--LNSD----DEDTEDSDDD-----------------------DDSQEG SADRLLVF------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Homo_sapiens_SPOCK3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKE VG-QWNKFR----------------------DEVEDDYFRTWSPGKPFDQ--ALDPAKDPCLKMKCSRHKVCIAQDSQTA -----------------------------VCISHRRLTH--------------------------RMKEAGVDHRQWR-G PILSTCKQCP--------------------------------VVYP---SPVCGSDGHTYSF------------------ -QCKLEYQACVLGKQ-----------------------------ISVKCEGH---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------SDKPT--STSRNVK R---------------------ACSDLEFREVANR---LRDWFKALHESGSQNKKTK--------------TLLRPERS- ---------------------RFDTSILPICKDSLG-WMFNRLDTNYDLLLDQ-----------------------SELR SIYLDKN--EQCTKA-----FFNSCD-TYKDS----------------------------------------------LI SNNEWCYCFQRQQ------DPPCQTELSNIQKRQG---VKKLLG-----QYIPLCDEDGYYKPTQCHG-----SVGQCWC VDRYG--NEVMGSRINGVAD--CAIDFEISGDFASGDFHEWTDDEDDED---DIMNDEDE-----IEDDD-EDEGDDDDG -GDDHDVYI----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Macaca_mulatta_SPOCK3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKE VG-QWNKFR----------------------DEVEDDYFRTWSPGKPFDQ--ALDPAKDPCLKMKCSRHKVCIAQDSQTA -----------------------------VCISHRRLTH--------------------------RMKEAGVDHRQWR-G PILSTCKQCP--------------------------------MVYP---SPVCGSDGHTYSF------------------ -QCKLEYQACVLGKQ-----------------------------ISVKCEGH---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------SDKPT--STSRNVE R---------------------ACSDLEFREVANR---LRDWFKALHESGSQNKKTK--------------TLLRTERS- ---------------------RFDTSILPICKDSLG-WMFNRLDTNYDLLLDQ-----------------------SELR SIYLDKN--EQCTKA-----FFNSCD-TYKDS----------------------------------------------LI SNNEWCYCFQRQQ------DPPCQTELSNIQKRQG---VKKLLG-----QYIPLCDEDGYYKPTQCHG-----SVGQCWC VDRYG--NEVMGSRINGVAD--CEP-HSFVQAFNHGDFHEWTDDEDDED---DIMNDEDE-----IEDDD-EDEGDDDDG -GDDHDGYI----------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Mus_musculus_SPOCK3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MLKVSALLCVCAAAWCSQTLAAAAAVAVAGGRSDGGNFLDEKQWLTTISQYDKE VG-QWNKFR----------------------DEVEDDYFRTWNPGKPFDQ--ALDPAKDPCLKTKCSRHKVCITQDAQTA -----------------------------LCISHRRLTH--------------------------SMKEVGGSHKQWR-G LPSSTCKPCP--------------------------------IAYA---SPVCGSDGHSYSS------------------ -QCKLEYQACVLGKQ-----------------------------ISIKCEGR---------------------------- -CPCP--------------------------------------------------------------------------- ------------------------------------------------------------------SDKSM--NIGRNVK R---------------------ACSDLEFREVANR---LRDWFKALHESGSQNKKTK--------------ALLRPERS- ---------------------RFDTSILPICKDSLG-WMFNRLDTNYDLLLDQ-----------------------SELG SIYLDKN--EQCTKA-----FFNSCD-TYKDS--------------------------------------------