>Homo_sapiens_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------MALTPGWGSSAGPVRPELWLLL-WAAAWRLG -ASACP-------------------------------------ALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELN--- GNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIP RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRTFRLHSNHLFCDCHLAWLSQ WLRQ-RPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSG---QGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCIRPDAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADFLR TNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDY--QLNSECNSDVVCPHKCRCEANVVECSSLKL TKIP----ERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSG MFRGLDGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWL RKR--KIVTGNPRCQNPDFLRQIP---LQDVAFPDFRCEE-------GQEEGGCLPRP-QCPQECACLDTVVRCSNKHLR ALPKG-IPKNVTELYLDGN-QFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQG LRSLR-LLSLHGNDISTLQEGIFADVTSLSHL----AIGANPLYCDCHLRWLSS-WVK--TGYKEPGIARCAG---PQDM EGKLLLTTPAKKFECQG-------PPTLAVQAKCDLCLSSPCQNQGTCHND-PLEVYRCACPSGYKGRDCEVSLDSCSSG PCENGGTCHAQEG-EDAPFTCSCPTGFEGPTCGVNTDDCVDHAC-ANGGVCVDGVGNYTCQ------------------- ---CPLQYEGK---------ACEQLVDLCSPDLNPCQHEAQCVGTPDGPR---------CECMPG---YAGDNCSENQDD CRDHRCQNG--------AQCMDEVN---SYSCLCA-----EGYSGQLCEIPPHLPAPK---SPCEGTECQNGANCVDQ-G NR---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------AETINDGQFHTVELVAFDQMVN-LSID GG------SPMTMDNFGKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTGFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPA---------------DGPCHGHKCVH GQ-CVPLD------------------------------ALSYSCQCQDGYSGALCNQAGA-------------------- -----------LAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGEL-CEQ--ESE---------CRGDPVRDFHQVQRGY AICQTTRPLSWVECRGSCP---------------------------GQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTK CGCALCA------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Gorilla_gorilla_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MLPELLFQNNQALSRLDLSENAIQAIP RKAFRGATDLKNLQLDKNRISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRTFRLHSNHLFCDCHLAWLSQ WLRQ-RPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSG---QGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCIRPDAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLSLFQT---PNSCKATLNFHAHLLD VNN-IDFA-AVLLAPRDLTFKRPGAVAHTCFRCSAK-EQYFIPGTEDY--QLNSECSSDVVCPHKCRCEANVVECSSLKL TKIP----ERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSG MFRGLDGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWL RKR--KIVTGNPRCQNPDFLRQIP---LQDVAFPDFRCEE-------GQEEGSCLPRP-QCPQECACLDTVVRCSNKHLR ALPKG-IPKNVTELYLDGN-QFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALRCIPPLAFQG LRSLR-LLSLHGNDISTLQEGIFADVTSLSHL----AIGANPLYCDCHLRWLSS-WVK--TGYKEPGIARCAG---PQDM EGKLLLTTPAKKFECQG-------PPTLAVQAKCDPCLSSPCQNQGTCHND-PLEE---------QGRDCEVSLDSCSSG PCENGGTCHAQEG-EDVPFTCSCPTGFEGPTCGVNTDDCVDHAC-ANGGICVDGVGNYTCQ------------------- ---CPLQYEGK---------ACEQLVDLCSPDLNPCQHEAQCVSTPDGPR---------CECMPG---YAGDNCSENQDD CRDHRCQNG--------AQCMDEVN---SYSCLCA-----EGYSGQLCEIPPHLPAPK---SPCEGTECQNGANCVDQ-G NR---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------AETINDGQFHTVELVAFDQMVN-LSID GG------SPMTMDNFGKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTGFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKLYCLHGICQPNATPGPMCHCESGWVGLHCDQPA---------------DGPCHGHKCVH GQ-CVPLD------------------------------ALSYSCQCQDGYSGALCNQAGA-------------------- -----------LAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGEL-CEQ--ESE---------CRGDPVRDFHQVQRGY AICQTTRPLSWVECQGSCP---------------------------GQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTK CGCALCA------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Pongo_abelii_SLIT1 -----MTAGWERARGCVCVWCVRRVRARAGPAHFPPRSSQLGAGGRERETQAAKRRGAERPPPKAPSLRPRTGAVAWRSK VPPSPQGRRAQARGLFGGSAPGLHLEAAPDGDGQRLLPSGSRAGRGEGTMALTPGWGSSAGPVRPELWLLL-WAAAWRLG -ASACP-------------------------------------ALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELN--- GNNITRIHKNDFVGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIP RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRT------------------- -----------------------------------------QGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCIRPDAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADFLR TNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDY--QLNSECNSDVVCPHKCRCEASVVECSSLKL TKIP----ERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAGSVSELHLTANQLESIRSG MFRGLDGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWL RKR--KIVTGNPRCQNPDFLRQIP---LQDVAFPDFRCEE-------GQEEGGCLPRP-QCPQECACLDTVVRCSNKHLR ALPKG-IPKNVTELYLDGN-QFTLVPGQL-STFKYLQLV------------------------ILSYNALQCIPPLAFQG LRSLR-LLSLHGNDISTLQEGIFADVTSLSHL----AIGANPLYCDCHLRWLSS-WVK--TGYKEPGIARCAG---PQDM EGKLLLTTPAKKFECQG-------PPTLAVQAKCDPCLSSPCQNQGTCHND-PLEVYRCACPSSYKGRDCEVSLDSCSSG PCENGGTCHAQEG-EDAPFTCSCPTGFEGPTCGVNMDDCVDHAC-ANGGVCVDGVGNYTCQ------------------- ---CPLQYEGK---------ACEQLVDLCSPDLNPCQHEAQCVGTPDGPR---------CECMPG---YAGDNCSENQDD CRDHRCQNG--------AQCIDEVN---SYSCLCA-----EGYSGQLCEIPPHLPAPK---SPCEGTECQNGANCVDQ-G NR---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------AETINDGQFHTVELVAFDQMMN-LSID GG------SPMTMDNFGKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTGFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPA---------------DGPCHGHKCVH GQ-CVPLD------------------------------ALSYSCQCQDGYSGALCNQAGA-------------------- -----------LAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGEL-CEQ--ESE---------CRGDPVRDFHQVQRGY AICQTTRPLSWVECRGSCP---------------------------GQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTK CGCALCA------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Macaca_mulatta_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------MALTPGWGSSAGPVRPELWLLL-WAAAWSLG -ASACP-------------------------------------ALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELN--- GNNITRIHKNDFVGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIP RKAFRGATDLKNLQLDKNQINCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRTFRLHSNHLFCDCHLAWLSQ WLRQ-RPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSG---QGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCIRPDAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADFLR TNP-IETSGARCASPRRLSNKRIGQIKSKKFRCSAK-EQYFIPGTEDY--QLNSECNSDVICPHKCRCEASVVECSSLKL TKIP----ERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSG MFRGLDGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWL RKR--KIVTGNPRCQNPDFLRQIP---LQDVAFPDFRCEE-------GQEEGGCLPRP-QCPQECACLDTVVRCSNKHLR ALPKG-IPKNVTELYLDGN-QFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQG LRSLR-LLSLHGNDISTLQEGIFADVTSLSHL----AIGANPLYCDCHLRWLSS-WVK--TGYKEPGIARCAG---PLDM EGKLLLTTPAKKFECQG-------PPTLAVQAKCDPCLSSPCQNQGICHND-PLEVYRCACPSGYKGRDCEVSLDSCSSG PCENGGTCHAQEG-KDAPFMCSCPTGFEGPTCGVNTDDCVDHAC-ANGGVCVDGVGNYTCQ------------------- ---CPVQYEGR---------ACEQLVDLCSPDLNPCQHEARCVGTPDGPR---------CECVPG---YAGDNCSENQDD CRDHRCQNG--------AQCMDEVN---SYSCLCA-----EGYSGQLCEIPPHLPTPK---SPCEGTECQNGANCVDQ-G NR---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVIVSQNQGRDLVSWG----- ------------EPAGVSGEVPR---QGWSRLTPTPG-WGTPSCSS-------AETINDGQFHTVELVAFDQMVN-LSID GG------SPMTMDNFGKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTGFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CLKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPA---------------DGPCHGHKCVH GQ-CVPLD------------------------------ALSYSCQCQDGYSGALCNQAGA-------------------- -----------LAEPCRGLQCLHGHCQASATKGAHCVCDPGFSGEL-CEQ--ESE---------CRGDPVRDFHQVQRGY AICQTTRPLSWVECRGSCP---------------------------GQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTK CGCALCA------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Callithrix_jacchus_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MLPELLFQNNQALSRLDLSENAIQAIP RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRTFRLHSNHLFCDCHLAWLSQ WLRQ-RPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSG---PGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNSIKSIPPGAFSRYRKLRRIDLSNNQIAEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCIRPDAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADFLR TNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDY--QLNHEFVYTYVYAHRC-LQASVIYICKFFM AFLM----DLKCPSFVDVRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSG MFRGLDGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGDWL RKR--KIVTGNPRCQNPDFLRQIP---LQDVAFPDFRCEE-------GQEEGGCLPRP-QCPQECACLDTVVRCSNKHLR ALPRG-VPKNVTELYLDGN-QFTLVPGQL-FTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQG LRSLR-LLSLHGNDISTLREGIFADVTSLSHL----AIGANPLYCDCHLRWLSS-WVK--TGYKEPGIARCAG---PPDM EGKLLLTTPAKKFECQG-------KPRIGVGEKGFLCFSVAAGSSGYLHSQCILEMLEGSAIAGRQGRDCEVSLDSCSSG PCENGGTCHAQED-EDAPFTCSCPTGFEGPTCGVNTDDCVEHAC-ANGGICVDGVGNYTCQ------------------- ---CPLQYEGR---------ACEQLVDLCSPDLNPCQHKAQCVGTPDGPR---------CECVPG---YAGDNCSENQDD CRDHRCQNG--------AQCVDEVN---SYSCLCA-----EGYSGQLCEIPPHPPAPK---SPCEGTECQNGANCVDQ-G NR---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------AETINDGQFHTVELVAFDQMVN-LSID GG------SPMTMDNFGKHYTLNSEAP--------------------------------LYVG----------GMPVDIN SAAFR-----LWQILNGTSFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKLYCLHGICQPNATPGPTCHCEAGWGGLHCDQPT---------------DGPCHGHKCVH GQ-CVPLD------------------------------ALSYSCQCQDGYSGALCNQAGA-------------------- -----------PAEPCRGLQCLHGHCQASANKGAHCVCDPGFSGEL-CEQ--ESE---------CRGDPVRDFHQVQRGY AVCRTTRPLSWVECQGSCP---------------------------GQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTK CGCALCA------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Mus_musculus_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------MALTPQRGSSSGLSRPELWLLL-WAAAWRLG -ATACP-------------------------------------ALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELN--- GNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENFLQAVP RKAFRGATDLKNLQLDKNRISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRTFRLHSNHLFCDCHLAWLSQ WLRQ-RPTIGLFTQCSGPASLRGLNVAEVQKGEFSCSG---QGEAAGAPACTLSSGSCPAMCSCSSGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCIRPDAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADFLR TNP-IETTGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDY--HLNSECTSDVACPHKCRCEASVVECSSLKL SKIP----ERIPQSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGAASVSELHLTANQLESIRSG MFRGLDGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFNCNCHLSWLGDWL RKR--KIVTGNPRCQNPDFLRQIP---LQDVAFPDFRCEE-------GQEEVGCLPRP-QCPQECACLDTVVRCSNKHLQ ALPKG-IPKNVTELYLDGN-QFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQG LRSLR-LLSLHGNDVSTLQEGIFADVTSLSHL----AIGANPLYCDCRLRWLSS-WVK--TGYKEPGIARCAG---PPEM EGKLLLTTPAKKFECQG-------PPSLAVQAKCDPCLSSPCQNQGTCHND-PLEVYRCTCPSGYKGRHCEVSLDGCSSN PCGNGGTCHAQEG-EDAGFTCSCPSGFEGPTCGVDTDDCVKHAC-VNGGVCVDGVGNYTCQ------------------- ---CPLQYTGR---------ACEQLVDFCSPDMNPCQHEAQCVGTPDGPR---------CECMLG---YTGDNCSENQDD CKDHKCQNG--------AQCVDEVN---SYACLCV-----EGYSGQLCEIP---PAPR---SSCEGTECQNGANCVDQ-G SR---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------AETINDGQFHTVELVTFDQMVN-LSID GG------SPMTMDNFGKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTSFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPV---------------DGPCHGHKCVH GK-CVPLD------------------------------ALAYSCQCQDGYSGALCNQVGA-------------------- -----------VAEPCGGLQCLHGHCQASATKGAHCVCSPGFSGEL-CEQ--ESE---------CRGDPVRDFHRVQRGY AICQTTRPLSWVECRGACP---------------------------GQGCCQGLRLKRRKLTFECSDGTSFAEEVEKPTK CGCAQCA------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Rattus_norvegicus_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------MALTPQRGSSSGLSRPELWLLL-WAAAWRLG -ATACP-------------------------------------ALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELN--- GNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENSLQAVP RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRTFRLHSNHLFCDCHLAWLSQ WLRQ-RPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSG---QGEAAQVPACTLSSGSCPAMCSCSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCIRPDAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADFLR TNP-IETTGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDY--HLNSECTSDVACPHKCRCEASVVECSGLKL SKIP----ERIPQSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQLESVRSG MFRGLDGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWL RKR--KIVTGNPRCQNPDFLRQIP---LQDVAFPDFRCEE-------GQEEVGCLPRP-QCPQECACLDTVVRCSNKHLQ ALPKG-IPKNVTELYLDGN-QFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQG LRSLR-LLSLHGNDVSTLQEGIFADVTSLSHL----AIGANPLY-DCHLRWLSS-WVK--TGYKEPGIARCAG---PPEM EGKLLLTTPAKKFECQG-------PPSLAVQAKCDPCLSSPCQNQGTCHND-PLEVYRCTCPSGYKGRNCEVSLDSCSSN PCGNGGTCHAQEG-EDAGFTCSCPSGFEGLTCGMNTDDCVKHDC-VNGGVCVDGIGNYTCQ------------------- ---CPLQYTGR---------ACEQLVDFCSPDLNPCQHEAQCVGTPEGPR---------CECVPG---YTGDNCSKNQDD CKDHQCQNG--------AQCVDEIN---SYACLCA-----EGYSGQLCEIP---PAPR---NSCEGTECQNGANCVDQ-G SR---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------AETINDGQFHTVELVTFDQMVN-LSID GG------SPMTMDNFGKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTSFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPV---------------DGPCHGHKCVH GK-CVPLD------------------------------ALAYSCQCQDGYSGALCNQVGA-------------------- -----------VAEPCGGLQCLHGHCQASATRGAHCVCSPGFSGEL-CEQ--ESE---------CRGDPVRDFHRVQRGY AICQTTRPLSWVECRGACP---------------------------GQGCCQGLRLKRRKLTFECSDGTSFAEEVEKPTK CGCAPCA------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Oryctolagus_cuniculus_SLIT1 MRTSSTCLQRKFAGVGNPAVRGPSPGNSWIPWFPPGESSQLGAAGRERETQAARNPSGAERPPPKAPSPGPRTSAVAGSR KVPPSPQGRSAGLAGCGVALPRTAPGGGPARGWSAAAAVWHASGRGEGTMALTAQRGS-----RPELWLLLLWAAACLPG -ASACP-------------------------------------ALCTCSGTTVDCHGTGLQAVPKNIPRSTERLELN--- GNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHTLPELLFQNNQALSRLDLSENAIQSIP RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRTFRLHSNHLFCDCHLAWLSQ WLRQ-RPTIGLFTQCAGPASLRGLNVAEVQKNEFSCSG---QGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIQSIPPGAFSPYRKLRRIDLSNNHISEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFSGLY TLQLL-LLNANKINCIRPDAFQDLQN--LSLLSLYDNKIQSLARGTFTSLRAIQTLHLAQN---PFICDCSLKWLADFLR TNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDY--QLNSECNSDVVCPHKCRCEASVVECSSLKL TKIP----ERIPQSTAELRLNNNEIAILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSG MFRGLDGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTIAPGAFDTLQALSTLNLLANPFNCDCQLAWLGDWL RKR--RVVTGNPRCQNPDFLRQIP---LQDVAFPDFRCEE-------GQEEGGCLPRP-QCPQECACLDTVVRCSNKHLR ALPVG-IPKNVTELYLDGN-QFTQVPGQL-STFKFLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQG LRSLR-LLSLHGNDVATLQEGTFTDVTSLSHL----AIGANPLYCDCHLRWLSS-WVK--TGYKEPGIARCAG---PPHM EGKLLLTTPAKKFECQG-------PPTLAVQAKCDPCLSSPCQNQGTCHND-VLERYRCTCASGYKGRDCEVSSDSCFSS PCGNGGTCQAQEG-EDAGFTVSCALG----RCGVGSEDDVDSTG-RGGQSCLSVPPNYLMQKTLLLS------------- ---CPLKWEAAP--------VTPSLKPLCCQSPKPWQETVNFR---TGPA---------CECAPG---YAGDNCSENQDD CRDHRCQNG--------AQCVDEVN---SYTCVCA-----EGYSGQLCEIPSQPPAPR---SPCEGTECQNGANCVDQ-G SR---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------TETINDGQFHTVELVTFDQMVN-LSID GG------SPMTMDNFGKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTSFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKLYCLHGICQPDATPGPVCHCDAGWGGVHCDQPA---------------DGPCLGHKCVH GK-CVPLD------------------------------ALSYSCQCQEGYSGALCNQAGA-------------------- -----------PAEPCGGLQCLHGHCQASAAKGAHCVCDPGFSGEL-CEQ--ESE---------CRGDPVRDFHQVQRGY AICQTTRPLSWVECRGSCP---------------------------GSGCCRGLRLKRRKLTFECSDGTSFAEEVEKPTK CGCALCA------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Canis_familiaris_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------MALAPRRGPPARRVRPELWLLL-WAAAWRLG -ATACP-------------------------------------ALCTCTGATVDCHGAGLQAIPKNIPRSTERLELN--- GNNITRIHKNDFVGLKQLRVLQLMENQIGVVERGAFDDMKELERLRLNRNQLHTLPELLFQNNQALSRLDLSENTIQAIP RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRTFRLHSNHLFCDCHLAWLSQ WLRQ-RPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSG---QGEAGRVPSCTLSSGSCPAMCSCSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCVRPDAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADFLR TNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDY--QLNSECNSDAVCPHKCRCEASLAECSSLKL TKIP----ERIPQSTAELRLNNNEISILEATGIFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSG MFRGLDGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNQIATISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWL RRR--KIVTGNPRCQNPDFLRQIP---LQDVAFPDFRCEE-------GQEEGSCLPRP-QCPQECACLDTVVRCSNKHLH VLPKG-IPKNVTELYLDGN-QFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQG LRSLR-LLSLHGNDISTLREGIFTDVTSLSHL----AIGANPLYCDCHLRWLSS-WVK--TGYKEPGIARCVG---PPDM EGKLLLTTPAKKFECQG-------PPTLAVQAKCDPCLSSPCRNQGTCHND-PLEVYRCVCSSGYKGRDCEVSLDGCSSS PCGNGGTCRPQEG-GDAGFTCSCPPGFEGPTCEVNTDDCVEHTC-ANGGICVDGVGNYTCQ------------------- ---CPLQYTGR---------GCEQLVDFCSSDLNPCQHEAQCVGTPDGPR---------CECAPG---YVGDNCSENQDD CRDHRCQHG--------AQCVDEVN---SYSCLCA-----EGYSGQFCEAPPRPPAPR---SPCEGTECQNGANCVDQ-G SG---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHMAVELY----QGHVRVSYDPGSYPSSAIYS-------AETINDGQFHTVELVTFDQMVN-LSID GG------SPMTMDNFGKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTSFHGCIRNLY-------------------INNELQDFTK-----------------TRMKPG VVPGCEP-----------CRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPA---------------DGPCHGHKCVH GK-CVPLD------------------------------ALSYSCQCQDGYSGALCNQARA-------------------- -----------PADPCGGLQCLHGHCQVLATKGAHCVCDPGFSGEL-CEQ--ESE---------CRGDPVRDFHQVQRGY AICQTTRPLSWVECRGSCP---------------------------GQGCCQGLRLKRRKLTFECSDGTSFAEEVEKPTK CGCAVCA------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Felis_catus_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------MALTPGRGPSAGLVRPELWLLL-WAAAWRLG -ATACP-------------------------------------ALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELN--- GNNITRIHKNDFVGLKQLRVLQLMENQIGVVERGAFDDMKELERLRLNRNQVHSLPELLFQNNQALSRLDLSENTIQAIP RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRTFRLHSNHLFCDCHLAWLSQ WLRQ-RPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSG---QGEAGRVPSCTLSSGSCPAMCTCSNGIVDCRGKGLTAIP ANLPES-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCVRPDAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---PFICDCNLKGLADFLR TNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDY--QLNSECNSDVVCPHKCRCEASLVECSSLKL TKIP----ERIPQSTAELRLNNNEISILEATGIFKKLTHLKKINLSNNKVSEIEDGAFEGAGSVSELHLTANQLESIRSG MFRGLDGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNQIATISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWL RRR--KIVTGNPRCQNPDFLRQIP---LQDVAFPDFRCEE-------GQEEGGCLPRP-QCPQECACLDTVVRCSNKHLQ VLPKG-IPKNVTELYLDGN-QFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQG LRSLR-LLSLHGNDISTLQEGIFTDVTSLSHL----AIGANPLYCDCHLRWLSG-WVK--TGYKEPGIARCAG---PPDM EGKLLLTTPAKKFECQG-------PPALAVQAKCDPCLSSPCQNQGTCHND-ALEAYRCVCSSSYKGRDCEVSLDSCSSS PCGNGGTCHPRQG-EDAGFMCSCPTGFEGPTCEVNTDDCVEHTC-ANGGTCVDGVGNYTCQ------------------- ---CPLQYAGR---------ACEQLVDFCSPDLNPCQHGAQCVGTPDGPR---------CECASG---YAGNNCSENQDD CRDHRCQHG--------ARCVDGVN---SYSCLCA-----EGYSGQFCETPPRPPAPR---SPCEGTECQNGANCVDQ-G SG---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------AETINDGQFHTVELVTFDQMVN-LSID GG------SPMTMDNFGKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTSFHGCIRNLY-------------------INNELQDFTK-----------------TRMKPG VVPGCEP-----------CRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPA---------------DGPCHGHKCVH GQ-CMPLD------------------------------ALSYSCQCQDGYSGALCNQAGA-------------------- -----------PVDPCGGLQCLHGHCQALATKGAHCVCDPGFSGEL-CEQ--ESE---------CRGDPVRDFHQVQRGY AICQTTRPLSWVECRGSCP---------------------------GQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTK CGCALC-------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Bos_taurus_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------DLSENTIQAIP RKAFRGATDLKNLQLDKNQIGCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRTFRLHSNHLFCDCHLAWLSQ WLRQ-RPTIGLFTQCSGPAGLRGLNVAEVQKSEFSCSG---QGEAGRTPSCTLSSGSCPAMCACSNGIVDCRGKGLTAIP ANLPEA-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQISEIAPDAFQG-LRSLNS-LVLYGNKITDLPQGVFGGLF TLQLL-LLNANKINCIRLDAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADFLR SNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGAEDY--QLNSECNSDVVCPHKCRCEASMVECSSLKL TKIP----ERVPQATAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSG MFRGLEGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNQIATISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWL RKR--KIVTGNPRCQNPDFLRQIP---LQDVASPDFRCEE-------GQEEGGCLPRP-QCPQECACLDTVVRCSNKHLQ TLPKG-IPKNVTELYLDGN-QFTLVPAQL-STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNSLQCIPPLAFQG LRSLR-LLSLHGNDISTLQEGIFADVTSLSHL----AIGANPLYCDCHLRWLSS-WVK--TGYKEPGIARCAG---PLDM EGKLLLTTPAKKFECQG-------PPTLTVQAKCDPCLSSPCQNQGTCRND-PLVGYRCACPSGYKGRDCEVSLDSCSSS PCGNGGTCRSQEG-EDAGFTCSCPTGFEGPTCGVDTDDCVEHSC-ANGGTCVDGVGSYTCQ------------------- ---CPLQYSGR---------ACELLVDFCAPDLNPCQHEAQCVGTPDGPR---------CECAPG---YAGGNCTEKQDD CRDHRCQNG--------AQCVDEAN---GYSCLCT-----QGYSGQLCETPPRPPGPR---SPCEGTECQNGANCVDQ-G NG---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------TETINDGQFHTVELVTFDQMVN-LSID GG------SPMTMDNFGKHYTLNSDAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTSFHGCIRNLY-------------------INNELQDFTK-----------------TRMKPG VVPGCEP-----------CRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPA---------------DGPCHGHKCVH GK-CVPLD------------------------------ALSYSCQCQDGYSGALCNQAGA-------------------- -----------PADPCEGLRCLHGHCQASATKGTYCVCDPGFSGEL-CEQ--ESE---------CRGDPVRDFHQVQRGY AICRTTRPLSWVECRGSCP---------------------------GQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTK CGCALCA------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Equus_caballus_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------MALTPRRGPSAGLARPELWLLL-WAAAWRLG -ATACP-------------------------------------ALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELN--- GNNITRIHKNDFAGLKQLRVLQLMENQIGVVERGAFDDMKELERLRLNRNLLHTLPELLFQNNQALSRLDLSENTIQAIP RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNISTIPVSSFN-HMPKLRTFRLHSNHLFCDCHL-WLSQ WLRQ-RPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSG---QGEAGRVPSCTLSSGSCPAMCTCSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCIRPDAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADFLR TNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDY--QLNSECNSDVVCPHKCRCEASMVECSSLKL TKLP----ERVPQSTAELRLNNNEISILEATGMFKKLNHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSG MFRGLDGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNQIATISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWL RKR--KIVTGNPRCQQPDFLRQIP---LQDVAFPDFRCEE-------GREEGGCLPRP-QCPQECACLDTVVRCSNKHLQ ALPKG-IPKNVTELYLDGN-QFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQG LRSLR-LLSLHGNDISTLREGIFADVTSLSHL----AIGANPLYCDCHLRWLSS-WVK--TGYKEPGIARCAG---PPDM EGKLLLTTPAKKFECQG-------PPTLAVQAKCDPCLSSPCQNQGTCHDD-PLEVYRCACPSGYKGRDCEVSLDSCSSG PCGNGGTCHPQEG-EEAGFTCSCPTGFEGPTCGVNTDDCVEHAC-ANGGICVDGVGNYTCQ------------------- ---CPLLYSGR---------ACEQLVDFCSPDLNPCQHEAQCVGTPDGPR---------CECAPG---YTGDNCSENQDD CRDHGCQNG--------AQCMDEVN---SYSCVCA-----EGYSGQLCETPPRPPAPR---SPCEGTECQNGADCVDQ-G SR---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------AETINDGQFHTVELVTLDQMVN-LSID GG------SPMTMDNFGKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWPILNGSSFHGCIRNLY-------------------INNELQDFTK-----------------TRMKPG VVPGCEP-----------CRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPA---------------DGPCHGHKCVH GK-CVPLD------------------------------ALSYSCQCQDGYSGALCNQAGA-------------------- -----------PADPCGGLQCLHGHCQASATKGAHCVCDPGFSGEL-CEQ--ESE---------CRGDPVRDFHQVQRGY AICQTTRPLSWVECRGSCP---------------------------GQGCCQ---------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Loxodonta_africana_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------DLSENTIQAIP RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRTFRLHSNHLFCDCHLAWLSQ WLRQ-RPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSG---QGEAGRVPSCTLSSGSCPAMCTCSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCIRPDAFQDLQN--LSLLSLYDNKIQGLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADFLR TNP-IETSGARCATPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDY--QLNSECNSDVVCPHKCRCEASVVDCASLKL TKIP----ERIPQSTAELRLNNNEISILEATGIFKKLTHLKKINLSNNKLSEIEDGAFEGAASVSELHLTANQLESIRSG MFRGLDSLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTISPGAFDTLQSLSTLNLLANPFNCNCRLAWLGDWL RKR--KIVTGNPRCQNPDFLRQIP---LQDVAYPDFRCEE-------GQEEGGCLPRP-QCPQECTCLDTVVRCSNKHLR ALPKG-IPKNVTELYLDGN-QFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQG LRSLR-LLSLHGNDISTLRE-IFADVTPFFHIQ---AIGANPLYCDCHLRWLSG-WVK--TGYKEPGIARCAG---PPDM EGKLLLTTPAKKFECQG-------PPTLAVQAKCDPCLSSPCQNQGTCHND-PLEVYRCACPSGYKGRNCEVSLDGCISG PCENGGTCLAQEG-DDASFTCSCPTGFEGPTCGVNTDDCVEHAC-ANGGSCVDGVGNYTCQ------------------- ---CPLQYVGK---------ACEQLVDFCSPDLNPCQHDAQCVGTPDGPR---------CECMPG---YTGHNCSENQDD CGNHRCQNG--------AQCVDEVN---SYSCLCA-----EGYSGQLCEIPPRPPAPR---SPCEGTECQNGANCVDQ-G SQ---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------AETINDGQFHTVELVTFDQMVN-LSID GG------SPMTMDNFDKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTSFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPA---------------DGPCHGHKCVH GN-CVPLD------------------------------ALSYSCQCQDGYSGALCSQAGA-------------------- -----------PADPCGGLRCLHGHCQASATKGSHCVCDPGFSGEL-CEQ--ESE---------CRGDPVRDFHQVQRGY AICQTTRPLSWVECRGACP---------------------------GQGCCQGLRLKRRKFTFECRDGTSFAEEVEKPTK CGCALCV------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Dasypus_novemcinctus_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------RDLSENTIQAIP RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNISTIPVSSFN-HMPKLRTLITDDLFLCLKNEFGDLGQ YICLNRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSG---QGEAGRVAACTLSSGSCPAVCTCSNGIVDCRGKGLTAIP ANLPEA-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCIRPDAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADFLR TNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDY--QLNSECSSDVVCPHKCRCEAGVVECSSLKL TKIP----ERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSG MFRGLEGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWL RKR--KIVTGNPRCQNPDFLRQIP---LQDVAFPDFRCEE-------GQEEGGCLPRP-QCPQECTCLDTVVRCSNKHLR VLPKG-IPKNVTELYLDGN-QFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFRG LRSLR-LLSLHGNDISTLREGIFADVTSLSHL----AIGANPLHCDCHLRWLSG-WVK--TGYKEPGIARCSG---PPDM EGKLLLTTPAKKFECQG-------PPSLAVQAKCEPCLSSPCQNQGTCHNH-PVEVYRCTCPSGHQGRDCEVSLDSCSSG PCENGGTCLPQEG-EDAGFTCSCPTGFEGPTCGVNTDNCMEHAC-ANGGTCVDGMGNYTCQ------------------- ---CPPQYVGR---------ACEQLVDFCSLDLNPCQHEAQCVGTPDGPR---------CECAPG---YTGDNCSENQDD CRDHRCQNG--------AQCVDDVN---SYSCLCA-----EGYSGQLCEIPPRLPASR---SPCEGTECQNGAHCVAQ-G SR---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------AETINDGQFHTVELVTFDQMVN-LSID GG------SPMTMDNFGKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQVLNGTSFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKLYCLHGICQPNASPGPVCHCEAGWGGLHCDQPA---------------DGPCHGHKCVH GK-CVPLD------------------------------ALSYSCQCQDGYSGALCNQAGA-------------------- -----------PADPCGGLQCLYGHCQASATKGAHCVCDPGFSGEL-CEQ--GSE---------CRGDPVRDFHQVQRGY AICQTTRPLSWVQCRGSCP---------------------------GQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTK CGCALCA------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Monodelphis_domestica_SLIT1 -------------------------------------------------------------------------------- --------------------------------------------------MALKHRAGHSAWLRPEVWLLV-WNALCQLC -ARGCP-------------------------------------ALCTCTGTTVDCHGMGLRAVPKNIPRNTERLELN--- GNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMRELERLRLNRNHLHLLPELLFQNNQALSRLDLSENSIQAIP RKAFRGATDLKNLQLDKNQISCIEDGAFRALRGLEVLTLNNNNITTIPVSSFN-HMPKLRTFRLHSNHLFCDCHLAWLSQ WLRQ-RPSIGLFTQCAGPASLRSLNVAEVQKNEFSCSG---PGEATRAPVCTLSSGSCPPMCACSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQISEIAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFGGLY TLQLL-LLNANKINCVRADAFQDLQN--LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADFLR TNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFLPGTEDY--QLNSECNSDAICPHKCRCESIVVECSNRKL NKE---------------RLNNNEISILEATGIFKKLPHLKKINLSNNKVAEIEDGAFEGAASVSELHLTVNQLESIRSG MFRGLDGLRTL-MLRNNRISCIHNDSFTGLRNVRLLSLYDNQISTISPGAFDTLQSLSTLNLLANPFNCNCQLAWLGDWL RRR--KIVTGNPRCQNPDFLRQIP---LQDVAFPDFRCEE-------GQEEGGCLPRP-QCPQECTCLDTVVRCSNKHLR ALPKG-IPKNVTELYLDGN-QFTLVPAQL-STFRYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNSLQCIPPLAFEG LRSLR-LLSLHGNDISTLREGIFTDVTSLSHL----AIGANPLYCNCHLRWLSS-WVK--TGYKEPGIARCAG---PPDM EGKLLLTTPAKKFECQG-------PPSIAVQAKCNPCLSSPCQNQGSCQND-PLDSYRCACPSGYKGRDCEMSLNSCSSG PCENGGTCHSGAG-EGAGFTCSCPMGFEGPTCGVDTDDCRDHTC-ENGGICEDGINNYTCV------------------- ---CPLQYTGR---------ACEQLVDFCSQDLNPCQHGAKCVGTPEGPK---------CECAPG---YIGDNCSINYDD CTHHQCQNG--------ARCVDEVN---GYSCLCE-----EGYSGQLCEMASQLLKPL---SPCEGAECQNGANCVDL-G NR---------PVCQCLPGFGGPECEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVATAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVRVSYDPGSYPSSAIYS-------AETINDGQFHTVELVTFDQMVN-LSID GG------SPMTMDNFGKHYTLNREAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTSFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKLYCLHGICQPNAAQGPICHCEPGWGGPHCDQQL---------------GHPCQGHKCVH GT-CVPLD------------------------------ALSYSCQCQDGYRGALCNQPGE-------------------- -----------PLDPCENLHCLHGHCQISSEGAARCVCRSGFAGEL-CEQ--ARELESPF----CQGDSVWDFHLVQSGY AICQTTRP----ACRGSCL---------------------------GQGCCTGLRMKRRRFTFECSDGSSFVEDVEKTIK CGCAGCM------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Anolis_carolinensis_SLIT1 -------------------------------------------------------------------------------- -------------------------------------------------------MAPRKRAAAPWALLLASWAALGVSG -ASACP-------------------------------------ALCACSGTTVDCHGLGLRAVPKNIPRGAERLELN--- GNNITRINKHDFAGLKQLRVLQLMENQISVVERGVFDDMKELERLRLNRNQLHTLPELLFQNNQALSRLDLSENLLQAVP RKAFRGATDLKNLQLDKNHISCIEEGAFRALRGLEVLTLNNNNITTIPISSFN-HMPKLRTFRLHSNQLFCDCHLGWLSQ WLRQ-RPTIGLFTQCAGPPALRGLNVAEIQKNEFTCTG---QDDATRAQICSFSSGSCPAMCTCSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIKSIPPGAFSSYKKLRRIDLSNNQISELAPDAFQG-LRSLNS-LVLYGNKITELPKGVFGGLY ALQLL-LLNANKINCIRADTFADLQN--LSLLSLYDNKIQTLAKGTFTTLRAIQTLHLAQN---PFICDCNLKWLADFLR ANP-IETSGARCASPRRLANKRIGQIKSKKFRCSPK-EQYFIPGTEDY--QLNSECHSDVVCPPKCRCEANVVECSNLKL TKIP----ERLPQATAELRLNNNEITVLEATGIFKKLPHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLDSVRSS MFRGLEGLRTL-MLRNNRINCIHNDSFTGLRNVRLLSLYDNQISTISPGAFDTLQSLSTLNLLANPFNCNCRLAWLGDWL RKR--KIVTGNPRCHNPDFLRQIP---LQDVAFPDFRCEE-------GQEETSCFPRP-QCPQECTCLDTVVRCSNKHLK ALPKG-IPKNVTELYLDGN-QFTLVPGQL-STFRYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFEG LRSLR-LLSLHGNDVSMLPEGIFADVTSLSHL----AIGANPLYCDCHMRWLSG-WVK--TGYKEPGIARCAG---PTDM EGKLLLTTPAKKFECQA-------PPPVAIQAKCNPCLSNPCQNKGTCQQD-PLDSYQCACPNKYKGRNCEFSVDSCSSR PCENGGTCLSHDG-AGVGFMCFCIDGFEGPTCSLKTNSCNDSSC-KNGGTCITGTSNYTCM------------------- ---CLPFYTGT---------YCEQLVDVCSPELNPCQHGAICRISSEGPK---------CECMPG---YMGDNCSMNYDD CLDHRCQNS--------AKCLDEPN---GYSCLCA-----GGYSGQLCEIPPHRSLQP---TPCERAECQNGANCVEL-G SR---------ALCQCLPGFGGPKCEKLLSVNF----VDRDTYLQFTDLQNWPSANITLQVSTAEDNG-ILLYNG----- ------------DTDHMAVELY----QGHVRVSYDPGTYPSSAIYS-------AETINDGQFHTVELVTFERMVN-LSID GG------DPMTMDGFGKVHTLNPDAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGSSFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKLYCLHGICQPNTPHGPICRCDPGWVGPHCDQPI---------------SNPCQGHKCVH GI-CVPLD------------------------------PLSYSCQCQEDYKGALCNQQGE-------------------- -----------LHNPCKNLQCVHGQCQISDTGEAYCECNGGFDGDL-CDQ--ESE---------CRGEAMRDFHQVQRGY AICQTTRPVSWVECRGSCP---------------------------GPGCCVGLRLKRRKYTFECSDGSSFVEEVEKPSK CGCSQCM------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Xenopus_tropicalis_SLIT1 -------------------------------------------------------------------------------- ---------------------------------------------------MDAKGSPTFPLWLRAGVWILAWSWICQVC -ANGCP-------------------------------------ALCTCSGTTVDCHGLALKGVPKNIPRSTERLELY--- GNNITRINKNDFSGLKQLRVLQLMENQISNVERGAFDDMKELERLRLNRNQLHTLPELLFQNNQALSRLDLSENLIQAIP RKTFRGATELKNLQLDKNQISCIEDGAFRALRGLEVLTLNNNNITAIPVSSFN-HMPKLRTFRLHSNNLFCDCHLAWLSQ WLRQ-RPTIGLFTQCTGPSPLRGLNVAEIQKHEFSCSG---QSDPPSSQICSLSIGSCPAMCTCSNGIVDCRGKGLTAIP ANLPET-MTEIRLELNGIKSVPPGAFSPYKKLRRIDLSNNQISEIAPDAFQG-LRSLNS-LVLYGNKITDLPKGVFSGLH ALQLL-LLNANKINCIRADTFQDLQN--LSLLSLYDNKIQSLAKGTFAALRAIQTLHLAQN---PFICDCNLKWLADFLR TNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDY--QLNSECNSDVVCPPKCRCESNVVDCSNLKL TKIP----DRIPQSTAELRLNNNEIATLEATGLFRKLPHLKKINLSNNKISEIEDAAFEGAASVSELHLTANHLESVRSG MFRGLEGLRTL-MLRNNRVSCVHNDSFTGLRNVRLLSLYDNQISTITPGAFDTLQSLSTLNLLANPFNCNCQLAWLGDWL RKR--KIVTGNPRCQNPDFLRQIP---LQDVAFPDFRCED-------GQEELSCAPQP-QCPQECTCLDTVVRCSNKHLL SLPKG-IPKNVTELYLDGN-QFTMVPGQL-SSFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNSLQCIPPLAFEG LRSLR-LLSVHGNDISSLPEGIFSDVTSLSHL----AIGANPLYCDCNLRWLSN-WVK--TGYKEPGIARCTG---PPEM DGKLLLTTPAKKFECNG-------PPSLNILAKCNPCLSDPCKNQGTCQDD-AVQYYKCVCPAGFKGKNCEISLNACSSN PCENQGLCLSKE--EGSGFMCTCADGFEGPTCAVNKDDCKYSDC-ENGGTCLDGINNYTCL------------------- ---CPSQYTGE---------YCEHLVDICSTDLNPCHSDSKCTVTPEGPK---------CECAPG---YGGDDCSLNYDD CKDHRCQNN--------ALCVDEVN---GYSCLCT-----EGYSGQLCEMP---SQAP---SPCKLTPCQNGANCIEV-G NS---------AVCQCLPGFGGSKCEKLLSVNF----VDRDTYLQFTDLQNWPRANITLQVSTAEDNG-ILLYNG----- ------------DHDHMAVELY----QGHVRVSYDPGSFPSSAIYS-------AETINDGQFHTVELVTFDQMVN-LSID GG------APMTMDKFGKHYTLNSEAP--------------------------------LYVG----------GMPVDVN SAAFR-----LWQILNGTSFHGCIRNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKLFCLHGICQPNAANGPVCHCETGWAGPHCDQQL---------------NDPCQGHKCVH GA-CMPLD------------------------------ALTYSCLCQDGYKGALCNQQGE-------------------- -----------LYNPCKTLQCQHGRCQISDLGEAYCECESGYVGDN-CDQ--ESE---------CRGEPVRDYYQVQRGY AICQTTRTVSWVECRGSCH---------------------------NQGCCTGLRMKRRKYTFECSDGSSFVEDVEKPIK CGCAQCV------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Danio_rerio_SLIT1_a -------------------------------------------------------------------------------- ----------------------------------------------------------MPARGGCCLLEVCVWVLLLVCK TGSGCP-------------------------------------ALCTCSGTTVDCHGLGLKNIPRNIPRNTERLELN--- GNNLTRINRNDFTGLKYLRVLQLMENQIVTVERGAFDEMRELERLRLNRNQLHQLPELLFQKNAALSRLDLSENFIQAIP RKAFRGATDIKNLQLDKNHISCIEDGAFRAMRGLEVLTLNNNNISSIPVSSFN-HMPKLRTFRLHSNNLVCDCVLSWLSQ WLRE-RPNIGLFTQCSSPAPLRGLNVAEVQKHEFSCSG---QSDSAVGQSCSLSSGSCPAVCSCNNNIVDCRGKGLTLIP SSLPDS-MTEIRLEQNSIKSIPPGAFSPYKKLRRIDLSNNQISELAPDAFQG-LRSLNS-LVLYGNKITDLPRGVFDGLH ALQLL-LLNANKIHCLRANTFQDLQN--LSLLSLYDNKIQTLAKGTFSSLRAIQTLHLAQN---PFICDCNLKWLADYLR SNP-IETSGARCTSPRRLANKRIGQIKSKKFRCSAK-EQYVIPGTEDS--RLNNDCNNDPVCPAKCRCESNVVDCSNLRL DRIP----EHIPASTTELRLNNNEITTIEAMGAFKTLTHLKKINLSNNKISEIEDGAFEGASSVNELHLTANQLDSVHSR MFRGLEGLRML-MLRNNRISCIHNNSFTGLHNVRLLSLYDNTLTTIAPGAFDTLQSLSTLNLLANPFNCNCRLAWLSSWL RNR--KIVTGNPRCHRPAFLKEIP---LQDVAAPDFRCED-------DHEDVSCAPPV-HCPADCTCLESVVRCSNKHLQ ALPKG-IPRNITELYLDGN-QLSTVPKEL-SSFKSLQLVDLSNNRISSLTNSSFTNMSQLTTLILSYNALRCIPTLAFSG LRSLR-LLSLHGNDISELPDGIFSDAQSLSHL----AIGANPLHCDCGLRWLSD-WVK--TGYKEPGIARCAS---PHGM EGKLLLTTPAKRFECQG-------EVDSAILAKCNPCASGPCLHQGVCEAD-QTDGYRCRCADGFKGKNCETVVNACVSE PCKNGGTCHVSTD-EDEGYSCSCAAGFEGPSCEVDTDECRDNDC-QNGATCIDGINNYTCL------------------- ---CAPFYTGE---------MCEDLEDMCSSARSPCKQQSTCFITVTGPK---------CICAAG---YVGEDCSVNYDD CKDHRCQNG--------AQCVDELN---GYSCVCQ-----KGYSGQLCEVA---PPPR---SPCERADCQNNAPCVER-A GH---------PLCQCLEGFGGPRCEKLVSVNF----VDRDSYLLLSDLKNWPQANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVEIH----EGHVKVSYDPGSQQSHAIYS-------TETVNDGQFHTVELVTFDQMVN-LSID GG------SPTTMDSFGKVQPLRGEAP--------------------------------LYVG----------GMPVSVH PTAPR-----VWQIQNSSSFHGCIQNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CRKIYCLHGICQPNTATGPVCHCQPGWSGQHCDQPL---------------ANPCMGSKCVH GR-CIPMD------------------------------MQSYRCECQEGFHGALCNQHEE-------------------- -----------LFNPCRKLQCKHGHCQISDTGDAYCHCEPGYSGDL-CDR--ESE---------CRGEPVRDFYQVQRGY SICQTTRMVSWVECSGVCE---------------------------SGSCCASQRMKRRKYSFECSDGTSFSEEVEKTIK CGCVGCM------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Takifugu_rubripes_SLIT1_b -------------------------------------------------------------------------------- --------------------------------------------LVNMPLRGNRFGAFLCRQAGRPLWMWLVMLSALLMG NAGACP-------------------------------------ALCTCSGTTVDCHGLGLRTMPRNIPRNAERLELN--- GNNLTRITKSDFAGLKYIRVLQLMENQITVIERGAFDDMKELERLRLNRNQLQQLPELLFQKNPALSRLDLSENFIQSIP RKAFRGATDIKNLQLDKNHIGCIEDGAFRAMRGLEVLTLNNNNISSIPVSSFN-HMPKLRTFRLHSNNLHCDCHLGWLAQ WLRQ-RPTVGLFTQCTSPAELRGLNVAEVQKHEFSCSG---HQESFATQACSVGGGSCPAMCTCSNNIVDCRGKGLTAIP ANLPES-MAEIRLEQNGIKSVPPGAFSPYKKLRRIDLSNNQISEIAPDAFQG-LRSLNS-LVLYGNKITDLPKGVFDGLY ALQLL-LLNANKIHCVRANAFQDLQN--LSLLSLYDNKIQTLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADYLR SNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDT--RLSNACNSDPVCPPKCRCESNVVDCSNLKL TKIP----EHIPSSTNELRLNNNDITTLEASGAFKSLSQLKKINLSNNKITEIEDGAFEGASSVIELHLTANQIDSVRSS MFRGLEGLRML-MLRNNKISCVHNDSFTGLHNVRLLSLYDNQLTTITPGAFDTLQALSTLNLLANTFNCDCRLAWLGDWL RSR--KIVTGNPRCQRPGFLKEIP---LQDVAQPDFRCDE-------GQEELSCVPRP-QCPSECTCLETVVRCSNKHLH ALPKG-IPRNVTELYLDGN-QFSIVPKEL-SGFKYLQLVDLSNNRINSLTNSSFSNMSQLTTLILSYNSLRCIPKMAFGG LHSLR-LLSLHGNEISELPDGIFNDVTSLSHL----AIGANPLYCDCRLRWLSD-WVK--TGYKEPGIARCAG---PQGM EGKLLLTTPAKKFECTG-------DVDPEVLAKCNPCLSSPCLNQGVCHSD-LMEIYRCSCPPGFKGKNCETALNACVSG PCANGGTCRVEAEGDYTHHSCKCPLGFEGPTCQTNTDECEDHDC-ENGATCIDGVNNYTCF------------------- ---CPPYYTGE---------MCEEMEDVCAPGRSPCKHQSTCLIAPTGPK---------CVCAPG---YVGDDCSVDYND CEDHRCQNG--------AHCVDELN---GYSCVCR-----QGYSGQLCEVP---PSPL---SLCELADCQNSAPCVER-G GR---------ALCQCPPEFGGPRCEKLVSVNF----VDRDSYLLLSDLKNWPQANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVKVSYDPGSQPGHAIYS-------TETINDGQFHTVELVTFDQMVN-LSID GG------LPTTMDSFGAVRTLNGEAP--------------------------------LYVG----------GMPVDVH AGTFR-----LWQIQNGSSFHGCIQNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CKKIYCVHGICQPDGIQGPVCHCQPGWSGPHCDEPA---------------ANPCQGSKCVH GR-CIPLD------------------------------SQSYRCECDEGYRGALCNQEGE-------------------- -----------LFNPCRRLSCKHGRCQISDTGDAFCNCESGYTGEL-CDA--ESE---------CRGEPMRDFYQVQRGY AICQTTRMVSWVECSGVCD---------------------------KGACCASQRMKRRKYTFECSDGTSFSEEVEKTIK CGCVGCM------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Tetraodon_nigroviridis_SLIT1_a -------------------------------------------------------------------------------- -----------------------------------------------FPLSPGEQ-----SEAG-PLWMWLVMLSALLMG NVGACP-------------------------------------ALCTCSGTTVDCHGLGLRSMPRNIPRNAERLELN--- GNNLTRITKSDFAGLKYIRVLQLMENQITVIERGAFDDMKELERLRLNRNQLQQLPELLFQKNPALSRLDLSENFIQSIP RKAFRGATDIKNLQLDKNHIGCIEDGAFRAMRGLEVLTLNNNNISSIPVSSFN-HMPKLRTFRLHSNNLHCDCHLAWLAQ WLRQ-RPTVGLFTQCTLPAELRGLNVAEVQKHEFSCSG---HQDSSGLQACSVGGGSCPAMCTCSNNIVDCRGKGLTAIP ANLPES-MAEIRLEQNGIKSVPPGAFSPYKKLRRIDLSNNQISEIAPDAFQG-LRSLNSLLCVYGNKITDLPKGVFDGLY ALQLL-LLNANKIHCIRANAFQDLQN--LSLLSLYDNKIQTLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADYLR SNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDT--RLNNACNSDPVCPPKCRCESNVVDCSNLKL TKVP----EHIPSSTSELRLNNNDITTLEATGAFKSLSQLKKINLSNNKITEIEDGAFEGASSVIELHLTANQIDSVRSG MFRGLEGLRMM-MLRNNKISCVHNDSFTGLHNVRLLSLYDNQLTTITPGAFDTLQALSTLNLLANSFNCDCRLAWLGDWL RSR--KIVTGNPRCQRPGFLKEIP---LQDVALPDFRCDEA------GQEESSCVPRP-QCPSECTCLETVVRCSNKHLH ALPKG-IPRNVTELYLDGN-QFSIVPKEL-SGFKYLQLVDLSNNRINSLTNSSFSNMSQLTTLILSYNSLRCIPKMAFGG LHSLR-LLSLHGNEISELPDGIFNDVTSLSHL----AIGANPLYCDCRLRWLSD-WVK--TGYKEPGIARCAG---PQGM EGKLLLTTPAKKFECTG-------DVDPEVLAKCNPCLSSPCLNQGVCQSD-LMEIYRCSCPPGFKGKNCETALNACVSN PCANGGTCRVDEE-EEGEYICKCPLGFEGPTCQTNADDCEDHDC-ENGATCVDGVNNYTCF------------------- ---CPPYYTGE---------MCEEMEDVCAPERSPCKHQSTCLITPTGPK---------CVCSPG---YVGDDCSVDYND CGDHRCQNG--------AQCIDELN---GYSCVCH-----QGYSGQLCEVP---PSPL---SLCELADCQNNAPCVER-G GR---------ALCQCPPEFGGPRCEKLVSVNF----VDRDSYLLLSDPKNWPQANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVKVSYDPGSQPGHAIYS-------TETINDGQFHTVELVTYDQMVN-LSID GG------LPTTMDSFGAVRTLNGEAP--------------------------------LYVG----------G------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Tetraodon_nigroviridis_SLIT1_b -------------------------------------------------------------------------------- ---------------------------------------------------SGGGSSAAGCLPRVQLAWAAALLLVPWGG GVEACP-------------------------------------SPCSCLGATVDCHGRGIHAVPKNIPRATERLDLN--- GNNLTVISRTDFAGLRHLRVLHLMENQIVAVERGAFDELKELERLRLNRNRLGQIPELLFQKNEALTRLDLSENVLQAIP RRTFRGATELKNLQLDKNHISCIEEGAFRALRTLEVLTLNNNNISSIPVSSFN-HMPKLRTFRLHSNSLRCDCHLA-LSP WLRQ-RASLGLYAQCSSPPSLRGLNLAELRKSDLACSG-----EAPPPGPCSLASGSCPPMCTCSNNIVDCRGRGLTAIP AHLPEA-MTEIRLEQNGIKSVPPGAFSSYKKLRRIDLSNNQIAEMAPDAFQG-LRALSS-LVLYGNKIAELPAGVFDGLS SLELL-LLNANRIHCIRASLFKDLEN--LALLSLYDNRIQSLAKGTFGSLRSIQTLHLAQN---PFVCDCHVRWLAEFLR ANP-IETSGARCASPRRLANKRIAQ-KSSKFRCSEKSPAYNNP-------RSSTSSQANRLCP------ANVVDCDNQRL TLFQPPPDQLPP-TPASQRLNNNDLSVLEATGAFKGLSQLKKINLSNNKISEIEDGAFEGAASVVELHLTANHLDAVRGS MFKGMEGLRML-MLRNNKISCLHNGSFTGLNNVRLLSLYDNQLSTILPGAFDTLPNLSTLNLLANPFNCDCRLSWFGAWL RSR--RIVTGNPRCQSPAFLREIP---LQDVAAPDFRCEDGA-----AQEEAGCGLGP-QCPSQCTCMDSVVRCSNKHLQ ALPRG-LPRNVTELYLDGN-QFTSVPKEL-ATFRFLQLVDLSNNKISFLSDDSFSNMSQLTTLWRLQTLSAASPLLALSG LRSLQIWLSLHGNDISELTDRASYSRRAPSLSHSVRAIGANPLYCDCRLLWLSD-WVK--SGYKEPGIARCAG---PGGV EGKLLLTAPAHSFQCDG-------PVEPSVRAKCSPCVSSPCQNQGVCKDD-HTQLFTCTCKPGFTGKHCETPVDACVSN PCTNGGVCLSDEQ--TGGFRCACAFGFHGTFCEVNVDDCQDHGC-ENGATCVDGVGNYTCL------------------- ---CAPSYKGL---------FCEEVDSVCGPGRNPCQHQSTCISTPAGPRILYL-----CNRIPG---WVGPECSIDYNE CVDHRCQNG--------AECVDHLD---GYSCVCP-----QGFSGQFCEAP---PPPA---SPCQLAQCQNGALCVEA-A GA---------AACTCAPGFEGQRCEKLVSVNF----LERDSYVQLQDVKNWPHANITLQVSTAEDNG-VLLYNG----- ------------DNEPIAVELH----QGHVRVTYDPGDQPATSIY----------------------------------- -----------TLEGRGRSQAAAGEAP--------------------------------LYVG----------GLPEEAV PAAP--------DAVNVSGFHGCIRKLY-------------------INHELQDFTR-----------------SHMGAG VEPGCQA-----------CRQSYCAHGTCQPDAAQGPRCHCHPGWAGPRCDRPATAEG-----VTVATGVDPCADSRCVQ GA-CVPVD------------------------------ARTYRCDCRDGYEGALCHLQRQ-------------------- -----------PASWCGRLPCVHGQCERTE-KAERCACEDGFSGQS-CDI--ELP---------CGGQPVRDHHRLRRGS ALCQTAKPFSWVECRGRCG---------------------------VATCCAPLRLRRRRLSFQCDDGTTFTQDVEKPVE CGCKECV------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Gasterosteus_aculeatus_SLIT1_a -------------------------------------------------------------------------------- ----------------------------------------------------------TGRRAG--LWMWVVMLSALLVG NVSACP-------------------------------------ALCTCSGTTVDCHGLGLKTMPRNIPRTTERLELN--- GNNLTRITKSDFAGLKYIRVLQLMENQITAIERGAFDDMKELERLRLNRNQLQQLPELLFQKNPALSRLDLSENFIQSIP RKAFRGATDIKNLQLDKNHISCIEDGGFRALRGLEVLTLNNNNISSIPVSSFN-HMPKLRTFRLHSNNLNCDCHLAWLAQ WLRQ-RPTIGLFTQCTAPSELRGLNVAEVQKHEFSCSG---HQEPGSPQPCSVGVGSCPAMCTCSNNIVDCRGKGLTAIP ANLPDT-MAEIRLEQNGIKSVPPGAFSPYKKLRRIDLSNNHISEIAPDAFQG-LRSLNS-LVLYGNKITDLPKGVFDGLY ALQLL-LLNANKIHCVRANAFQDLQN--LSLLSLYDNKIQTLAKGTFASLRAIQTLHLAQN---PFICDCNLKWLADYLR SNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYFIPGTEDT--RLNNACNSDPVCPPKCRCESNVVDCSNLKL TKIP----EHIPTSTSELRLNNNDITALEATGVFKSLSQLKKINLSNNKITEIEDGSFEGASAVNELHLTANQIDSVRSG MFRGLEGLRML-MLRNNKISCVHNDSFTGLHNVRLLSLYDNQLTTITPGAFDTLQTLSTLNLLANSFNCDCRLGWLGDWL RSR--KIVTGNPRCQRPAFLKEIP---LQDVALPDFRCEEG------QEEPSSCVPRP-QCPSECTCLETVVRCSNKHLH TLPKG-IPRNVTELYLDGN-QFNVVPKEL-STYKYLQLVDLSNNKINSLTNSSFANMSQLTTLILSYNSLRCIPKMAFSG LHSLR-LLSLHGNEISELPDGIFNDVASLSHL----AIGANPLHCDCHLRWLSD-WVK--TSYKEPGIARCAG---PQGM EGKLLLTTPAKKFECTG-------DVDTTVVAKCNPCVSSPCLNHGICHSD-MVEIYRCSCPPGFKGKNCETALDACLSS PCANRGTCQVNDG-EEGQYSCTCPLGFEGPTCQTNIDECEDNDC-ENGATCLDGVNNYTCF------------------- ---CPPYYTGE---------MCEEMEDVCAPGRSPCKHQSTCLITSNGPK---------CVCSPG---YVGDDCSVDYKE CEEHRCQNG--------AQCAPFHL---LHHQRRP--LSLGLRSGQLCEFL---PYAL---SLCELADCQNNAPCLER-G GR---------ALCQCPPEFGGPRCEKLVSVNF----IDRDSYLLLSDLKNWPQANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELY----QGHVKVSYDPGSQPGHAIYSS------TETINDGQFHTVELVTFDQMVN-LSID GG------LPTTMDSFGAVRPLNGEAP--------------------------------LYVG----------GMPVAVH SGAFR-----LWQLQNGSSFHGCIQNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CKKIYCVHGICQPDGFQGPVCHCQPGWTGPQCDQTA---------------TNPCQGTKCVH GK-CIPLD------------------------------PQSYRCECEEGYRGALCNQQGE-------------------- -----------LFNPCRRLSCKHGRCQISDTGEAYCHCESGYTGGL-CDA--ESE---------CRGEPVRDFYQVQRGY AICQTTRMVSWVECSGACD---------------------------AGACCASQRMKRRKYTFECSDGTSFSEEVEKTIK CGCVGCM------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Oryzias_latipes_SLIT1_a -------------------------------------------------------------------------------- -----------------------------------------------MSITGSCFEAGMGCPAV--QWMWLLMLSALIIG NASACP-------------------------------------ALCTCSGVTVDCHGLGLKTMPRNIPRNTERLELN--- GNNLTRITKSDFTGLKYVRVLQLMENQITVVERGAFDDMKELERLRLNRNQLQQLPELLFQKNPALSRLDLSENFIQSIP RKAFRGATDIKNLQLDKNHISCIEDGAFRAMRGLEVLTLNNNNISSIPVSSFN-HMPKLRTFRLHSNNLNCDCHLAWLAQ WLRQ-RPTIGLFTQCTVPSELKGLNVAEVQKHEFTCSG---HQESSSLQPCSIGGGSCPAMCTCSNNIVDCRGKGLTAIP ANLPDN-MAEIRLEQNGIKSVPPGAFSSYKKLRRIDLSNNQISEIAPDAFQG-LRSLNS-LVLYGNKITDLPKGVFDGLY ALQLL-LLNANKIHCIRANTFQDLQN--LSLLSLYDNKIQTLAKGTFTSLRAIQTLHLAQN---PFICDCNLKWLADYLR SNP-IETSGARCASPRRLANKRIGQIKSKKFRCSAK-EQYVIPGTEDV--RLNDACNSDPVCPPKCRCESNVVDCSNLKL TKIP----EHIPSSTSELRLNNNEITSLDANGAFKNLAQLKKINLSNNKITEIEDGTFEGASAVIELHLTANQIDSVRSG MFRGLEGLRML-MLRNNKISCVHNDSFTGLHNVRLLSLYDNQLTTITPGAFDTLQTLSTLNLLANSFNCDCRLAWLGDWL RSR--KIVTGNPRCQRPAFLKEIP---LQDVALPDFRCDEG------QEE-SSCIPRP-QCPSECTCLETVVRCSNKHLH SLPRG-IPRNVTELYLDGN-QFSIVPKEL-STFKYLQLVDLSNNKINSLTNSSFANMSQLTTLILSYNSLRCIPKMAFSG LHSLR-LLSLHGNEISELPDGIFNDVASLSHL----AIGANPLHCDCRLRWLSD-WVK--TGYKEPGIARCAG---PQGL EGKLLLTTPAKKFECHG-------DVDIAVLSKCNPCLSNPCMNHGICHND-PVEIYRCSCPPGFKGKNCESGLNACVSN PCANGGTCRVHED-NEGQYSCTCALGFEGPTCKINTDDCEDNDC-ENGATCVDGINNYTCF------------------- ---CPPYYTGE---------MCEEMEDVCAPGRSPCQHQSTCLITSSGPK---------CVCSPG---YVGDDCSIDYND CEEHRCQNG--------AQCVDELS---GYSCICPKGFRVSPRSGQLCEVP---PSPL---SLCELADCQNDAPCVER-G GR---------ALCQCPPEFGGPRCEKLVSVNF----IDRDSYLLLSDLKNWPQANITLQVSTAEDNG-ILLYNG----- ------------DNDHIAVELF----QGHVKVSYDPGSQPGHAIYS-------TETINDGQFHTVELVTFDQMVN-LSID GG------LPTTMDSFGAVRPLNREAP--------------------------------LYVG----------GMPVDVH SGTFR-----LWQIQNSSSFHGCIQNLY-------------------INNELQDFTK-----------------TQMKPG VVPGCEP-----------CKKLYCVHGICQPDGAQGPVCHCQPGWIGAHCDQPA---------------LNPCQGSKCVH GK-CIPLD------------------------------AQSYRCECQEGYRGALCNQQGE-------------------- -----------LFNPCRRLSCKHGRCQISDAGSAYCHCESGYTGEL-CDA--ESE---------CRGEPVRDFYQVQRGY AICQTTRMVSWVECSGACS---------------------------TGACCGSQRMKRRKYTFECSDGTSFSEEVEKTIK CGCVGCM------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------- >Oryzias_latipes_SLIT1_b ------------------------------------------------------------------