>Homo_sapiens_RUFY3 -------------------------------------------------------------------------------- MSALTPP----------------------------------TDMPTPTTDKITQ------------AAMETIYLCKFRVS MDG-------EWLCLRELDDISLTPDPEP-----------------THED------------------------------ -------------------------------------------------------------------------------- ------------------------------------------------------------------------------PN YLMANERMNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------AKKTFLG-QNKSFWGPLELVEKLV------------------------------------ ------------------PEAAEITASVKDLPG-LKTPVGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSEYMKALINKKELL---------------------SE FYEPNALMMEEEGAIIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------FCMKGEDLDSQ-VGVI DFSMYLKDG-NSSKGTE-G------------DGQITAILDQKNYVEELNRHL-----------NATVNNLQAKVDALEKS NTKLTEELAVANN-RIITLQEEMERVKEESSYILESNR-----------------KGPKQDRTAEGQALS---------- -------EARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQ--- -----------SSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEEL T--------------RQRNQLELELKQEKE------------------------RRLQNDRS-IPGRGSQK-SESKMDGK HKMQEEN------------VKLKKPLEESHRLQPHP-MDEQ-DQLLLSEKP--------QLCQL---------------- -----------CQEDG---SLTKNVCKNCSGTFCDACSTNELPLPSSIKLERVCNPCHKHLMKQYSTSPS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Pongo_abelii_RUFY3 -------------------------------------------------------------------------------- MSALTPP----------------------------------TDMPTPTTDKITQ------------AAMETIYLCKFRVS MDG-------EWLCLRELDDISLTPDPEP-----------------THED------------------------------ -------------------------------------------------------------------------------- ------------------------------------------------------------------------------PN YLMANERMNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------AKKTFLG-QNKSFWGPLELVEKLV------------------------------------ ------------------PEAAEITASVKDLPG-LKTPVGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSEYMKALINKKELL---------------------SE FYEPNALMMEEEGAIIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------FCMKGEDLDSQ-VGVI DFSMYLKDG-NSSKGTE-G------------DGQITAILDQKNYVEELNRHL-----------NATVNNLQAKVDALEKS NTKLTEEXAVANN-RIITLQEEMERVKEESSYILESNR-----------------KGPKQDRTAEGQALS---------- -------EARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQ--- -----------SSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEEL T--------------RQRNQLELELKQEKE------------------------RRLQNDRS-IPGRGSQK-SESKMDGK HKMQEEK------------VKLKKPLEESHRLQPHP-MDEQ-DQLLLSEKP--------QVCQL---------------- -----------CQEDG---SLTKNVCKNCRGTFCDACSTNELPLPSSIKLERVCNPCHKHLMKQYFTSPS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Macaca_mulatta_RUFY3 -------------------------------------------------------------------------------- MSALTPP----------------------------------TDMPTPTTDKITQ------------AAMETIYLCKFRVS MDG-------EWLCLRELDDISLTPDPEP-----------------THED------------------------------ -------------------------------------------------------------------------------- ------------------------------------------------------------------------------PN YLMANERMNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------AKKTFLG-QNKSFWGPLELVEKLV------------------------------------ ------------------PEAAEITASVKDLPG-LKTPVGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSEYMKALINKKELL---------------------SE FYEPNALMMEEEGAIIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------FCMKGEDLDSQ-VGVI DFSMYLKDG-NSSKGTE-G------------DGQITAILDQKNYVEELNRHL-----------NATVNNLQAKVDALEKS NTKLTEELAVANN-RIITLQEEMERVKEESSYILESNR-----------------KGPKQDRTAEGQALS---------- -------EARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQ--- -----------SSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEEL T--------------RQRRQDPFPDKKKKK------------------------KKLLS--F-IP--KLRH-CRRKYDGK HNMQEEN------------VKLKKPLEESHRLQPHP-TDEQ-DQLLLSGKP--------QVCQL---------------- -----------CQEDG---SLTKNVCKNCRGTFCDACSTNELPLPSSIKPERVCNPCHKHLMKQYSTSPS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Mus_musculus_RUFY3 -------------------------------------------------------------------------------- MSALTPP----------------------------------TDMPTPTTDKITQ------------AAMETIYLCKFRVS MDG-------EWLCLRELDDISLTPDPEP-----------------THED------------------------------ -------------------------------------------------------------------------------- ------------------------------------------------------------------------------PN YLMANERMNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------AKKTFLG-QNKSFWGPLELVEKLV------------------------------------ ------------------PEAAEITASVKDLPG-LKTPVGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSEYMKALINKKELL---------------------SE FYEVNALMMEEEGAIIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------FCMKGEDLDSQ-VGVI DFSMYLKDG-NSSKGSE-G------------DGQITAILDQKNYVEELNRHL-----------NATVNNLQTKVDLLEKS NTKLTEELAVANN-RIITLQEEMERVKEESSYLLESNRK-----------------GPKQDRTAEGQALS---------- -------EARKHLKEETQLRLDVEKELELQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQ--- -----------SSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ----SEKD---------LVKQAK-----TLNSAANKL I--------------PKHH------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Rattus_norvegicus_RUFY3 -------------------------------------------------------------------------------- MSALTPP----------------------------------TDMPTPTTDKITQ------------AAMETIYLCKFRVS MDG-------EWLCLRELDDISLTPDPEP-----------------THED------------------------------ -------------------------------------------------------------------------------- ------------------------------------------------------------------------------PN YLMANERMNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------AKKTFLG-QNKSFWGPLELVEKLV------------------------------------ ------------------PEAAEITASVKDLPG-LKTPVGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSEYMKALINKKELL---------------------SE FYEANALMMEEEGAIIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------FCMKGEDLDSQ-VGVI DFSMYLKDG-NSSKGSE-G------------DGQITAILDQKNYVEELNRHL-----------NATVNNLQAKVDALEKS NTKLTEELAVANN-RIITLQEEMERVKEESSYLLESNRK-----------------GPKQDRTAEGQALS---------- -------EARKHLKEETQLRLDVEKELELQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQ--- -----------SSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ----SEKD---------LVKQAK-----TLNSAANKL I--------------PKHH------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Felis_catus_RUFY3 -------------------------------------------------------------------------------- MSALTPP----------------------------------TDMPTPTTDKITQ------------AAMETIYLCKFRVS MDG-------EWLCLRELDDISLTPDPEP-----------------THED------------------------------ -------------------------------------------------------------------------------- ------------------------------------------------------------------------------PN YLMANERMNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------AKKTFLG-QNKSFWGPLELVEKLV------------------------------------ ------------------PEAAEITASVKDLPG-LKTPVGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSEYMKALINKKELL---------------------SE FYEPNALMMEEEGAIIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------FCMKGEDLDSQ-VGVI DFSMYLKDG-NSSKGSE-G------------DGQITAILDQKNYVEELNRHL-----------NATVNNLQAKVDALEKS NTKLTEELAVANN-RIITLQEEMERVKEESSYILESNR-----------------KGPKQDRTSDGQALS---------- -------EARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQ--- -----------SSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERDRQSAELDNRLFKQDFGDKINSLQLEVEEL T--------------RQRHQLELELKQERE------------------------RRLQNNRN-IPGKGFQK-PEPKTDGK HRIQEEN------------AKLKKPLDESHRCLLIK-YDIN-DQPLLSAKP--------QMCQL---------------- -----------CQQDG---RLAKNMCKNCRGTFCDACSTNELPLPSSIKPERVCNPCHEHLMKQYSASPS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Bos_taurus_RUFY3 -------------------------------------------------------------------------------- MAETSPPPTAGAESCSEEPARGGKQRPEEPRRAPAGGADREDEAGPPLASPAGQ------------SEPGSPVAAPFFLL YPGDGGAGFVARPPPQQQRSWRTPPSPGSPLPFLLLNYPSGGGGGGGKHH------------------------------ -------------------------------------------------------------------------------- ------------------------------------------------------------------------------PN YLMANERMNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------AKKTFLG-QNKSFWGPLDIVRRAL------------------------------------ ------------------VIALWISASESQETR-SRTPVGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSEYMKALINKKELL---------------------SE FYEPNALMMEEEGAIIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------FCMKGEDLDSQ-VGVI DFSMYLKDG-NSSKGSE-G------------DGQITAILDQKNYVEELNRHL-----------NATVNNLQAKVDALEKS NTKLTEELAVANN-RIITLQEEMERVKEESSYILESNR-----------------KGPKPDRTSEGQALS---------- -------EARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQQ-- -----------SSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERGRQSAELDNRLFKQDFGDKINSLQLEVEAL T--------------RQRNHLELELKQERE------------------------RRLQNSRS-IPGKGSQKPEEPKMDGK HKIQEEN------------VKLNKPLEESHRLQSHP-VDQQ-DQPLPSEKPP-------KYCQL---------------- -----------CQED---CSLTKNVCRNCRGTFCNICSTNELPLPSSIKPERVCNPCHEHLMKQYSTSPS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Loxodonta_africana_RUFY3 -------------------------------------------------------------------------------- MAETPSPPSAGAESYSEEPVRGGERRPEEPRSAPAGGADRESEAGPPLASPAAQ------------SEPDSPVAAPFFLL YPGNGGAGFPARLPPQQQRVWRTPPSPGSPLPFLLLSYPSGGGGGGGKHN------------------------------ -------------------------------------------------------------------------------- ------------------------------------------------------------------------------PN YLMANERMNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------AKKTFLG-QNKSFWGPLELVEKLV------------------------------------ ------------------PEAAEITASVKDLPG-LKTPVGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSEYMKALINKKELL---------------------SE FYEPNALMMEEEGAIIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------FCMKGEDLDSQ-VGVI DFSMYLKDG-NSSKGSE-G------------DGQITAILDQKNYVEELNRHL-----------NATVNNLQAKVDALEKS NTKLTEELAVANN-RIITLQEEMERVKEESSYILESNR-----------------KGPKQDRTSEGQALS---------- -------EARKHLKEETQLRLDVEKELEIQIGMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQ--- -----------SSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERGRQSAELDNRLFKQDFGDKINSLQLEVEEL T--------------RQRNQLELELKQERE------------------------RRLQNNSN-VPGKGSQK-TEPKTDGK HRIQEEN------------VNLKKPLEESHRLQSHP-MDQQ-DQPLLSEKP--------QVCQL---------------- -----------CQEDD--GSIKKNVCKNCKGTFCNACSTNELPLPSSITPERVCNSCHKHLMKQYSTSP----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Dasypus_novemcinctus_RUFY3 -------------------------------------------------------------------------------- MSALTPP----------------------------------TDMPTPTTDKITQ------------AAMETIYLCKFRVS MDG-------EWLCLRELDDISLTPDPEP-----------------THED------------------------------ -------------------------------------------------------------------------------- ------------------------------------------------------------------------------PN YLMANERMNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------AKKTFLG-QNKSFWGPLE-VEKLV------------------------------------ ------------------PEAAEITASVKDLPG-LKTPVGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSEYMKALINKKELL---------------------SE FYEPNALMMEEEGAIIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------FCMKGEDLDSQ-VGVI DFSMYLKDG-NSSKGSE-G------------DGQITAILDQKNYVEELNRHL-----------NATVNNLQAKVDALEKS NTKLTEELAVANN-RIITLQEEMERVKEESSYILESNR-----------------KGPKQDRTSEGQALT---------- -------EARKHLKEETQLRLDVEKELEIQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQ--- -----------SSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLHQAERGRQSAELDNRLFKQDFGDKINSLQLEVEEL T--------------RQRHRLELELKQERE------------------------SRLQNNRSSIPGKGMQK-PEPKMVEK QKIQEEN------------VKLKTPFEEIYRLQSHS-LDEQ-DQPPDSEKT--------DKLTL---------------- -----------LNKKMF-LSVTENVCKNCRGTFCNACSANELPLPSSIKPERVCNPCHQHLIKQYSTSPS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Gallus_gallus_RUFY3 -------------------------------------------------------------------------------- -------------------------------------------MPTPTTDKITQ------------AAMETIYLCKFRVS MDG-------EWLCLRELDDISLTPDPEP-----------------THED------------------------------ -------------------------------------------------------------------------------- ------------------------------------------------------------------------------PN YLMANERMNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------AKKTFLG-QNKSFWGPLELVEKLV------------------------------------ ------------------PEAAEITASVKDLPG-LKTPVGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSEYMKALINRKDLL---------------------SE FYEPNALMMEEEGAIIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------FCMKGEDLDSQ-VGVI DFSMYLKDG-NSTKGSE-G------------DGQITAILDQKNYVEELNRHL-----------SATVNNLQAKVDALEKS NTKLTEELAVANN-RIITLQEEMERVKEESSYILESNRK-----------------VTK-DRTADGQALT---------- -------EARKQLKEETQLRLDVEKELEAQIGMRQEMELAMKMLEKDVCEKQDALVALRQQLDDLRALKHELSFKLQ--- -----------SSDMGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAEKDRQLAQQDNRLFKQEFGDKINSLQLEVEEL S--------------RQRSHLELELKRERERWS------------------HSHQSSQGNK------KGP-KNWLKPDGK LRIQDENA-----------KLKQAPREENSVLPHKLQSSTQEEQEQPSGPGNAQICQL---------------------- ------------CQEESSRSKKKNICKNCGGIFCEACSANELPLPSSINPERVCNPCHKQLIQQYSTSPL---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Xenopus_tropicalis_RUFY3 -------------------------------------------------------------------------------- MSALTPP----------------------------------SDMPTPTTDKITQ------------AAMETIYLCKFRVS MDG-------EWLCLRELDDISLTPDPEP-----------------NPED------------------------------ -------------------------------------------------------------------------------- ------------------------------------------------------------------------------PN YLMANERMNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------AKKTFLG-QNKSFWGPLELVEKLV------------------------------------ ------------------PEAAEITASVKDLPG-LRTPVGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSEYMKALINRKDLL---------------------SE FYEPNALMMEEEGAIISG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------FCMKGEDLDSQ-VGVI DFSMYLKEG-PIAKCSE-G------------DGQITAILDQKNYVEELNRQL-----------SATVNNLQAKVDALEKS NTKLTEELAVANN-RIITMQEEMERIKEETSYYSEASKK-----------------VNKQERTADGQALS---------- -------EVKKHLKEETQLRLDIEKELEVQIGMRQEMELAMKMLDKDVCEKQDALAALRQQLDDLRALKHELSFKLQ--- -----------SSDLALKQKSELNSRLEEKTNQMAATVKQLEQ----SEKD---------LVKQAK-----TLNSVAHKL L--------------QKQH------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Danio_rerio_RUFY3a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------DP--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------K DPIAIERLNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------SKKTFLG-QNKSFWGPLELVEKLT------------------------------------ ------------------PEAGEITASVKDLPG-LKTPLGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSDYMKTIINRKDLL---------------------GE FYEPNALMMEEEGAVIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCMKGEDLDSQ-VGVI DFSMYLKDGAHSSKSTE-G------------DGQITAILDQKNYVEELNRHL-----------SASVNNLQAKVDALEKS NTKLTEELAVANN-RIITLQEELERVKEEGSYFVESSRK-----------------ASRADGTANGQVLG---------- -------ETRKQLKEETQLRLDVEKELELQIGMKQEMELSMKMLEKDICEKHDALVELRQQLDDVRTLNHELSVKSQ--- -----------SSESSAKQKSDIIGRLEEKTNQMGSIIKQLESRCKKAERERDLADEANRLFKQEFGDKIESLQTEVEQL R--------------RQRWILEQELKKGRD---------------------------HPG-VQTPETLLGKTPPQQRDSK QHIEDIRK-----------ENDTLRTALEEKTSLSSSLTLSHEDE-----------QNQSLCKEVD-------------- ------PSICTMCENQDSLTSPKSQCKNCSGVFCENCMANELPLPSSINPEHVCDVCYSQLLEQYSSSPS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Takifugu_rubripes_RUFY3a -------------------------------------------------------------------------------- -------------------------------------------------RAGDH------------LSLQLSRVRGRRVA LPAR---------AQRHLPHPGPRAGPHP--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------K DPIAIERLNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------TKKTFLG-QNKSFWGALELVEKLT------------------------------------ ------------------PEAGEITASVKDLPG-LKTPLGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSDYMKTIINRKDLL---------------------SE FYEPNALMMEEEGAVIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCMKGEDLDSQ-VGVI DFSMYLKDGGHSSKSAE-G------------DGQITAILDQKNYVEELNRHL-----------SASVNNLQAKVDALEKS NTKLTEELAVANN-RIITLQEDVERVKEESSYQLESRKKRVEAFLCYFIII--FLQAVRSDSASDGQALG---------- -------ETRKQLKEETLLRLDVEKELEVQIGMKQEMEMSMKMLEKDVCEKQDALVELRQQLEDLRAINQQLLHKTQ--- -----------SSDAGSKQKSETISRLDEKINQMTGTVKQMEARCKQAERERDLALEANRLFKQDFGDKIESLQEEVEQL K--------------KHRFYLERQLKKERE---------------------------QRS--ASRQVVIPQKEPRPTESS PKVSSNERKLLLWSRFSVTEYISPTVDSRRPVGQKGEQPVNHRSRGQIQS----QLQPESFVNISQ-------------- ------PSICSMCEEDESLLKTKKQCKNCSGVFCDSCVRNELPLPSSILPEIVCNGCFSLLLQQYASTPT---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Tetraodon_nigroviridis_RUFY3a -------------------------------------------------------------------------------- MSDLTPQ----------------------------------GETPTPTTDKITQ------------AARETIYLCNFRVS VDG-------EWLCLRELNDISLTPDPEP-----------------AHE------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------DPK DPIAIERLNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------TKKTFLG-QNKSFWGALELVEKLT------------------------------------ ------------------PEAGEITASVKDLPG-LKTPLGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSDYMKTIINRKDLL---------------------SE FYEPNALMMEEEGAVIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCMKGEDLDSQ-VGVI DFSMYLKDGGHSSKSAE-G------------DGQITAILDQKNYVEELNRHL-----------SASVNNLQAKVDALEKS NTKLTEELAVANN-RIITLQEDVERVKEESSYQLESRKA------------------VRSDSASDGQALG---------- -------ETRKQLKEETLLRLDVEKELEVQIGMKQEMEMSMKMLEKDICEKQDALVELRQQLEDLRAINQQLLHKSQ--- -----------TSDASSKQKNEAISRLEEKINQMSGTVKQMEA----SEKH---------LVKQAR-----NLNSAAGKL L--------------QFQQ------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Gasterosteus_aculeatus_RUFY3a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MNMGQ-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------TKKTFLG-QNKSFWGALELVEKLT------------------------------------ ------------------PEAGEITASVKDLPG-LRTPLGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSDYMKTIINRKDLL---------------------SE FYEANALMMEEEGAVIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCMKGEDLDSQ-VGVI DFSMYLKDGGHSSKSAE-G------------DGQITAILDQKNYVEELNRHL-----------SASVNNLQAKVDALEKS NTKLTEELAVANN-RIITLQEDVERVQEESSYQLETRKVSASSSLG---------SASRSESAPDGQVLG---------- -------ETRKQLKEETLLRLDVEKELEVQIGMKQEMELSMKMLEKDVCEKQDALVELRQQLEDLRVINQQLSHKSQ--- -----------SADAGSKQKSEAIARLEEKINQMSGTVKQMETRCKQAERERVLALEANRLFKQEFGDKIESLQVEVEQL R--------------KHRSHLELELRKERH---------------------------RHGDGSSSQSGVPRRETRLPEDI ANIPKVQLRVTTRPSIYIGQKGERAVQHGNRGQNQSELQLCLISEASTNPSLVYYVQDEEEEEVCQ-------------- ------PSICSMCERDDSLTKTKRRCKNCEGVFCEGCVSNELPLASSILPETVCTACYSLLLQQYASTPT---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Oryzias_latipes_RUFY3a -------------------------------------------------------------------------------- MSDLTPQ----------------------------------SETPTPTTDKITQ------------AARETIYLCNFRVS VDG-------EWLCLRELNDISLTPDPEP-----------------AHEEKWDSFKKSEDV------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------SPDPK DPVAIERLNLMNMAK-----------------LSIKGL------IESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-- --------------------TKKTFLG-QNKSFWGALELVEKLT------------------------------------ ------------------PEAGEITASVKDLPG-LRTPLGRG-------------------------------------- ------------------------------RAWLRLALMQKKLSDYMKTIINRKDLL---------------------SE FYEPNALMMEEEGAVIAG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCMKGEDLDSQ-VGVI DFSMYLKDGGHSSKSAE-G------------DGQITAILDQKNYVEELNRHL-----------SASVNNLQAKVDALEKA NTKLTEELAVANN-RIITLQEDVERVKEESSFQLESRKS------------------ARGDPAADGSALT---------- -------ETRKQLKEETLLRLDVERELEVQIGMKQEMEMSMKMLEKDVCEKQDALMELRQQLDDLRTINQQLSHKSQ--- -----------SADSSSKQKGEVIARLEDKISQMSGTVKQLES----SDKH---------LVKQAR-----NLSTSAGKL L--------------QLKP------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Ciona_savignyi_RUFY3 -------------------------------------------------------------------------------- ----------------------------------------------------GK------------KSMK---------- VE------------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------RRSLLGMAK-----------------LSVKGL------IESSLSAGHTLDSDHTPLQQFFVIIEYVLRQGLK-- --------------------APKNFFM-PNKYFWPPLEAIERLN------------------------------------ ------------------SEASEITSSVRSLPG-IRTHLGKG-------------------------------------- ------------------------------RAWLRLAIMQKKLADYFKILIDNKEML---------------------SE WYDEGALLMNEEATVLAG---------------------------------------------------------HLVGL NCIDAH----------------------------------------------------------LLHVSDSFEY--EMVI DYSLYMKDGNHG---IFMEEENG-----DEDESAMQKLVNQKNYLEERNRHLE-----------DSSNDLQKRTDQLEAE NKTMMQEVEALKI-QMSELKSEREKMI----------------REKDLDT---ERETLRKSKAGLDEMYT---------- -------QIQKQLKHETQMRMEVEKELELQMSMKHELEVAMKLLEKDIYDKQDGLVTLREQLDNVKAINLEIYKKLQ--- -----------SKSIVEEDKNKTILSLENETRSLAKKVSKLQQQLEEEERNTLVAR-----------EQAGRYNQQLDDM E--------------NKRIALTTNIQVEREWRQSLEAKLE-----------------KMEQDKVLLEEQLSVMSQLREEL RLVTIDR------------DDLRQSCMEQEHTINDLAGHLGESKQVLGDLKEVHKTMTS-SQWESDKQ------------ ------ASTCAQCEKPFNLARRKHHCRNCGQIYCNSCSDNTMPLASSAKPVRVCDTCHTTL------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Branchiostoma_floridae_RUFY3 -------------------------------------------------------------------------------- -------------------------------------MAEETIYLCNFRVSVDG------------EWLCLRELGDLSVT PQ--------------LESPQEVPEEND---------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------PPK DPTAIERANLLNMVK-----------------LSIKSL------IESSYQVGRTLDKDFAPLQQFLIVMEHVLKHGLK-- --------------------GVSHGLH-SNK---LTVSSGPSAA------------------------------------ ------------------PSKVQIHVPDSDVGT-LLTYPGKA-------------------------------------- ------------------------------RAWLRLAMMQKRLADYVKTLVEKK-DV--------------------MGE FYEPFALLMEEEGMVLAG---------------------------------------------------------LLVGL NVIDCN----------------------------------------------------------FCVKEDDFDSQ-LGVI DFSMYLKDPGNYTDRSPGE---------ASRKIFLTYILQ---LLENYRYHLSL----------ATVTNLQARIENLEKD NSNLSEKLAMANN-RVLQLQEEGDKLQTENTRIKGDLE---------------KKLVKSR--AGLDDMYV---------- -------EAQKQLRDETQMRLDVEKELELQISMKQEMEMAMKLLEKDIHEKQDMIVGLRKQLDDIKAINIDMYKKFQ--- -----------AAEGSLKHKTEMLVKLEEKCTQMSQTIKDIEQR------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----SVLLICVSVNCNEAV------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Homo_sapiens_RUFY1 ------------------------------MADREGGCAAGRGRELEPELEPGPGPGSAL---------------EPGEE FEIVDRSQLPGPGDLRSATRPRA-------------AEGWSAPILTLARRATGN------------LSASCGSALRAAAG LG------GGDSG-DGTAR----AASKCQ--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MMEERANLMHMMK-----------------LSIKVL------LQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLK-- --------------------VKKSFIG-QNKSFFGPLELVEKLC------------------------------------ ------------------PEASDIATSVRNLPE-LKTAVGRG-------------------------------------- ------------------------------RAWLYLALMQKKLADYLKVLIDNKHLL---------------------SE FYEPEALMMEEEGMVIVG---------------------------------------------------------LLVGL NVLDAN----------------------------------------------------------LCLKGEDLDSQ-VGVI DFSLYLKDVQDLDGGKE--------------HERITDVLDQKNYVEELNRHL-----------SCTVGDLQTKIDGLEKT NSKLQEELSAATD-RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKV---ELETYKQTRQGLDEMYS---------- -------DVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQ--- -----------NAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQL H--------------EQCSSLEKELKSEKEQRQALQRELQ---------------HEKDTSSLLRM--ELQQVEGLKKEL RELQDEK------------AELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKG-HAWLKDDE------------ ------ATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Pongo_abelii_RUFY1 ------------------------------MADREGGWAAGRERELEPEPEPGPGPGSAL---------------EPGEE FEIVDRSQLPGPGDLRSATRPRA-------------AEGWSAPILTLARRATGN------------LSASCGSALRAAAG LG------GGDSG-DGTAR----AASKCQ--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MMEERANLMHMMK-----------------LSIKVL------LQSALSLGRSLDADYAPLQQFFVVMEHCLKHGLK-- --------------------VKKSFIG-QNKSFFGPLELVEKLC------------------------------------ ------------------PEASDIATSVRNLPE-LKTAVGRG-------------------------------------- ------------------------------RAWLYLALMQKKLADYLKVLIDNKHLL---------------------SE FYEPEALMMEEEGMVIVG---------------------------------------------------------LLVGL NVLDAN----------------------------------------------------------LCLKGEDLDSQ-VGVI DFSLYLKDVQDLDGGKE--------------HERITDVLDQKNYVEELNRHL-----------SCTVGDLQTKIDGLEKT NSKLQEELSAATD-RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKV---ELETYKQTRQGLDEMYS---------- -------DVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQ--- -----------NAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQL H--------------EQCSSLEKELKSEKEQRQALQRELQ---------------HEKDTSCLLRT--ELQQVEGLKKEL RELQDEK------------AELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKG-HTWLKDDE------------ ------ATHCRQCEKEFSISRRKVRGSSTHPPSALSHCPLRFPLSLVPEAHIRPGSLPVTVLTGWQMGSPASPVCLCRWL SILAPSF------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Mus_musculus_RUFY1 ------------------------------MAARGECRRAGQDSEPEPEREPESEPGPEPEPQAG---------LESGEA FEIVDRSQLPSPGELRSASRPRV-------------ADSWSAPILTLARRATGN------------LSASCGSALRAAAG LG--------DGGGGG-ER----AASKGQ--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MMEERANLMHMMK-----------------LSIKVL------LQSALSLGRSLDADYAPLQQFFVVMEHCLKHGLK-- --------------------VKKSFIG-QNKSFFGPLELVEKLC------------------------------------ ------------------PEASDIATSVRNLPE-LKTAVGRG-------------------------------------- ------------------------------RAWLYLALMQKKLADYLKVLIDNKQLL---------------------SE FYEPEALMMEEEGMVIVG---------------------------------------------------------LLVGL NVLDAN----------------------------------------------------------LCLKGEDLDSQ-VGVI DFSLCLKDAQDLDSGRE--------------HERITDVLDQKNYVEELNRHL-----------SCTVGDLQTKIDGLEKT NSKLQEELSAATD-RICSLQKEQQQLREQNEVIRERSEKSVEITKQDTKV---ELETYKQTRQGLDEMYS---------- -------DVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKVQ--- -----------SAESSLQQKNEAIASFEGKTTQVMSSMKQMEERLQQAERARQAAEERSHKLQQELSGRGSALQLQLSQL R--------------DQCSGLEKELKSEKEQRQALQRELQ---------------REKDTSCLLQT--ELQQVEGLKKEL RELQDEK------------AELRKVCEEQEQALQEMGLHLSQSKLKMEDIKEVNKALKG-HTWLKDDE------------ ------ATHCKQCEKDFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Rattus_norvegicus_RUFY1 ------------------------------MAARGDCRRAGQDSEPEPKPEPESR--PEPGLQAG---------LESGEE FEIVDRSQLPSPGELRSASRTRA-------------AESWSAPILTLARRATGN------------LSASCGSALRAAAG LG--------DGGGGGGER----AASKGQ--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MMEERANLMHMMK-----------------LSIKVL------LQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLK-- --------------------VKKSFIG-QNKSFFGPLELVEKLC------------------------------------ ------------------PEASDIATSVRNLPE-LKTAVGRG-------------------------------------- ------------------------------RAWLYLALMQKKLADYLKVLIDNKHLL---------------------SE FYEPEALMMEEEGMVIVG---------------------------------------------------------LLVGL NVLDAN----------------------------------------------------------LCLKGEDLDSQ-VGVI DFSLYLKDVQDLDSGRE--------------HERITDVLDQKNYVEELNRHL-----------SCTVGDLQTKIDGLEKT NSKLQEELSAATD-RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKV---ELETYKQTRQGLDEMYS---------- -------DVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKVQ--- -----------SAESSLQQKDEAIASFEGKTTQVMSSMKQMEERLQQAERARQGAEERSYKLQQELSGRVSALQLQLSQL R--------------DQCSGLEKELKSEKEQRQTLQRELQ---------------HEKDTSCLLQT--ELQQVEGLKKEL RELQDEK------------AELRKVCEEQEQALQEMGLHLSQSKLKMEDIKEVNKALKG-HTWLKDDE------------ ------ATHCKQCEKDFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Felis_catus_RUFY1 ------------------------------MADGESGCPAGR----EPEQAPGP---------------------EPGEE FEIVDRSQLPSPSELRSAAKPRVG------------PEGWSAPILTLARKATGN------------LSASCGSALRAAAG LG------GADGGADGAAR----AASKCQ--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MMEERANLMHMMK-----------------LSVKVL------LQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLK-- --------------------VKKSFIG-QNKSFFGPLELVEKLC------------------------------------ ------------------PEASDIATSVRNLPE-LKTAVGRG-------------------------------------- ------------------------------RAWLYLALMQKKLADYLKVLIDNKHLL---------------------SE FYEPEALMMEEEGMVIVG---------------------------------------------------------LLVGL NVLDAN----------------------------------------------------------LCLKGEDLDSQ-VGVI DFSLYLKDVQGLDGGKE--------------HERITDVLDQKNYVEELNRHL-----------SCTVGDLQNKIDGLEKT NSKLQEELSAATD-RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKV---ELDTYKQTRQGLDEMYS---------- -------DVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKVQ--- -----------NAESCLQQKNEAITSFEEKTNQVMSSMKQMEERLRQSERARQGAEERSHRLQQELGGRTCALQQQLSQL H--------------EQCSSLEKELKSEKEQRQALQRELQ---------------QEKDTSSLLPI--LEKQAAVIAKEL RELQDEK------------AELQKVCEEQEQALQEMGLHLSQSKLKMEDIKEVNKALKG-HTWLKDDE------------ ------ATHCKQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSSTG---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Loxodonta_africana_RUFY1 ---------------------------------------PER--------GPEPGP-------------------ESGEE FEIVDRNQLPSPGELKSAAQPRAA------------ADGWSAPILTLARKATVN------------LSASCGSALRAAAG RG------VGDGIGDGAAR----AAAKCQ--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MMEERANLMHMMK-----------------LSIKVL------LQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLK-- --------------------VKKSFIG-QNKSFFGPLELVEKFC------------------------------------ ------------------PEASDIATSVKNLPE-LKTAVGRG-------------------------------------- ------------------------------RAWLYLALMQKKLADYLKVLIDNKHLL---------------------SE FYEPEALMMEEEGTVIVG---------------------------------------------------------LLVGL NVLDAN----------------------------------------------------------LCLKGEDLDSQ-VGVI DFSLYLKDVQDLDGGKE--------------HERITDVLDQKNYVEELNRHL-----------SCTVGDLQAKIDGLEKT NSKLQEELSAAAG-RICSLQEEQHQLREQNELIRERSEKSVEITKQDTKV---ELETYKQTRQGLDEMYS---------- -------DVWKQLKEEKRVRSELEKELELQIAMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKVQ--- -----------NAESNLQQKNEAITSFEGKTTQVMSSMKQMEERLQHSEQARQGAEERSHKLQQELGGRVSALQQQLAQL H--------------MQCSSLEKELKSEKEQRQALQRELQ---------------HEKDTSSLLRT--ELQQVEGLKKEL RELQDEK------------AELQKVCNEQEQALQEMGLHLSQSKLKMEDIKEVNKALKG-HTWLKDDE------------ ------ATHCKQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Dasypus_novemcinctus_RUFY1 ------------------------------MADGEDGGPAGR--------GPGPGP-------------------DPGEE FEIVDRSQLPGPGELRGSARPRAA------------AESWSAPILTLARRATGN------------LSASCGSALRAAAG ---------LDGGADGAAR----AASKSQ--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MMEERVNLMHMMK-----------------LSIKVL------LQSALSLGRSLDADHAPLQQFFVVMEHCLKHELK-- --------------------VKKSFIG-QNKSFFGPLELVEKLC------------------------------------ ------------------PEASDIATSVKNLPE-LKTAVGRG-------------------------------------- ------------------------------RAWLYLALMQKKLADYLKVLTDNKHLL---------------------SE FYEPEALMMEEEGMVIVG---------------------------------------------------------LLVGL NVLDAN----------------------------------------------------------LCLKGEDLDSQ-VGVI DFSLYLRDVQDLNGGKE--------------HERITDVLDQKNYVEELNRHL-----------SCTVGDLQAKVDGLEKT NSKLQEELSAATD-RICSLQQEQQQLREQNDLIRERSEKSVEITKQDTKV---ELETYKQTRQGLDEMYS---------- -------DVWKQLKEEKRVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEDVKAINLQMFHKVQ--- -----------SAESNLQQKNEAILSFEGKTNQAMSSMKQMEERLQHSERARQGAEERSRKLQQELGGRVGALQQQLSQL H--------------DQCSSLEKELKSEKEHRQALQRELQ---------------HEKDTSSLLRT--ELQQVEGLKKEL RELQDEK------------TDLQKVCDEQEQALQEMGLHLSQSKLKMEDIKEVNKALKG-HAWLKDDE------------ ------ATHCKQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTTS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Ornithorhynchus_anatinus_RUFY1 ------------------------------MAEEEAGVAPGP---------------------------------GSGPD SELGGGGGGEGEGEGEGCLAPRPAERSREEKEKAPEEAGWSAPILSLAKKASEN------------LSAGYGNALKSAVS VA-LVSKLPG--GGDHPAKTSRDPFPKCQ--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MMEERSNLMNMMK-----------------LSVKVL------IQSALSLGRSLDSDYPPLQQFFVVMEHCLKHGLK-- --------------------VKKSFIG-QNKSFFGPLELVEKLC------------------------------------ ------------------PEASDIATSVKNLPE-LKTAVGRG-------------------------------------- ------------------------------RAWLYLALMQKKLADYLKVLIDNKHLL---------------------SE FYEPEALMVEEEGAVIVG---------------------------------------------------------LLVGL NVLDAN----------------------------------------------------------LCLKGEDLDSQ-VGVI DFSLYLKDGQDIGGTENSR------------HENITDVLDQKNYVEELNRRL-----------SCTVGDLQAKIDCLEKT NAKLQEEAQCSAL-SCTSLTEEQLQLKKQNELIRERSEKSVEVTKQDTKV---ELETYKQTRQGLDELYS---------- -------DVWKQLKEEKRVRAELEKELELQIGLKTEMEIAMKLLEKDTHEKQDSLVALRQQVEEVKAINLQMFQKAQ--- -----------NAESSLQQKSEAITSYEGKTCQVMTAMKQMEERWRHSEKARQGAEEKNSKLKQEFGGQIEALRQQLSQL D--------------KQCSSLERELKSEKEQRQTLQQELE---------------REKDTTSLLKT--ELQQVDGLKQEL RKLQGEK------------EKLQNTCEEQEQALQEMGLHLSQSKLKMEDIKEVNKALKG-HTWLKDDE------------ ------ATQCKQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDACHTLLLQRCSSNSS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Gallus_gallus_RUFY1 ----------------------------------------------------------------------------MKED FEIIDKTQVPDTAELKNVE-----------KEK--EEAKWSAPILSLAKKASEN------------LALSYGSALKSAAS VG--------LISKAVSNDSTAKTTARHH--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --AMEERANLMNMMK-----------------LSIKTL------IQSALSLGRTLDSDFPPLQQFFVVLEHCLKHGLK-- --------------------AKKTFIG-QNKSFFGPLELVEKLC------------------------------------ ------------------PEASDIATSVKNLPE-LKTAVGRG-------------------------------------- ------------------------------RAWLYLALMQKKLADYLKVLLDHKHLL---------------------SE FYEPDALMMEEEGAVIVG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCLKGEDLDSQ-VGVI DFSLYLKETQDSD-GKQ--------------DGDITAVLDQKHYVEELNRHLR-C--------SCTVTDLQNKIDCLEKT NSKLQEELAAATD-RIGSLQEEQQQLKQQNELIRERSEKSVEVTKEDTKV---ELDTYRQSRQGLDEMYS---------- -------DVWKQLKEEKKIRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKSQ--- -----------NAECSLQQKTEAISSFEG-TNEMMSAMKQMEERLQHAEKARQAAEERCNKMKQELASRLDTCRQQMSQL D--------------SKCSTLEKELKSEKEQRQTLQRELH---------------REKDATSLLKT--ELEQMEGLKKEL RKLQDEK------------QQLEKVCEEQEQALQEMGLHLSQSKLKMEDIKEVNKALKG-HTWLKDDE------------ ------ATHCKQCEKEFSISRRKHHCRNCGDIFCNACSSNELALPSYPKPVRVCDSCHTLLLQRCSSNSS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Taeniopygia_guttata_RUFY1 ------------------------------------------------------------------------------ED FEIIDKKQLPDAAELSNEE-----------KAKP-EEARWSAPILSLARKASEN------------LALSYGSALKSASL VG--------LVDSPAK---TIRSRMRCH--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --TMEERANLMNMMK-----------------LSIKIL------IQSALSLGRTLDSDFPPLQQFFVVLEHCLKHGLK-- --------------------AKKTFIG-QNKSFFGPLELVEKLC------------------------------------ ------------------PEASDIATSVKNLPE-LKTAVGRG-------------------------------------- ------------------------------RAWLYLALMQKKLADYLKVLLDHKHLL---------------------SE FYEPDALMMEEEGAVIVG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCLKGEDLDSQ-VGVI DFSLYLKETQDSD-SKQ--------------DGGITAVLDQKHYVEELNRHL-----------SCTVADLQNKIDCLEKT NSKLQEELAAATD-RIGSLQEEQQQLKQQNELIRERSEKSVEVTKEDTKV---ELDTYKQSRQGLDEMYS---------- -------DVWKQLKEEKKIRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKSQ--- -----------NAECSLQQKTEAISSFEGKTNEMMSSMKQMEERLQQAEKARQAAEERCNKMKQELAGRLDSCRQQMAQL D--------------SKCSTLEKELKSEKEQRQTLQKELH---------------QEKDATTLLKT--ELQQMEGLKKEL RKLQDEK------------QQLKKVREEQEQALQEMGLHLSQSKLKMEDIKEVNKALKG-HTWLKDDE------------ ------ATHCKQCKKEFSISRRKHHCRNCGDIFCNTCSSNELALPSYPKPVRVCDNCHTLLLQQCSNSS----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Anolis_carolinensis_RUFY1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---MEERSNLMNMIK-----------------LSIKVL------IQSALSLGRTLDSDFPPLQQFFVVMEHCLKHGLK-- --------------------AKKSFIG-QNKSFFGPLELVEKLC------------------------------------ ------------------PEASDLATSVRNLPE-LKTPVGRG-------------------------------------- ------------------------------RAWLYLAVMQKKLADYLKVLLDHKHLL---------------------SE FYESDALMMEEEGAVMVG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCLKGEDLDSQ-VAVI DFSLYLKDTQSSDNGKE--------------DGGITAVLDQKHYVEELNRHL-----------SCTVGDLQTKIESLEKT NSKLQEELTAATD-RIRALQDEQQELRQQNEQIRERSEKHVEVTKEDTKV---ELETYKQTRQGLDEMYS---------- -------DAWKQLKEEKRIRMELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFNKSQ--- -----------NTETTLQQKKEAISSFEGKTNQIMSSIKQMEDRLQHAEKAKRDAEEKSVKLKRELGSRIETLKQQLSQL D--------------NKCSTLEKELKSEKEQRQTLQQELH---------------QEKDTTTLLKT--ELQQVEGLKKEL RKLQEEK------------QQLEKTCEEQEQALQEMGLHLSQSKLKMEDIKEVNKALKG-HTWLKDDE------------ ------ATHCKQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDTCHTLLLQRCSSNSS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Xenopus_tropicalis_RUFY1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------H--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --KMDERANLMNRMK-----------------LSIKVL------IQSALNLGRCIDSEYPPLQQFFLVMEHCLKHGLK-- --------------------VKKTFMA-QNKSFYGPLELVEKLC------------------------------------ ------------------PESSDLFANIKNLPE-LKTAIGKG-------------------------------------- ------------------------------RAWLHLALMQKKLADYLQALIDHKDLLR-------------------ISD FYEQDALMMEEEGAVIVG---------------------------------------------------------LLVGL NMIDAN----------------------------------------------------------LCLKGEDLDSQ-VGVI DFSFYLKDMQQNDNEKQ--------------SDEIVAVLDQKHYVEELNRHL-----------SCTVGDLQAKIDSLEKT NSKLTKELLAAKD-RIVSLQEEHNHILQESTLIREKSERSVEVSFQDTKV---ELDTYKQSRQGLDEMYN---------- -------EIWKQLKVEKQARLELEKEFELQVGMKTEMEMAMKLMEKDIHEKQDTLVVLRKQLDDVKAINLQMCQKVL--- -----------DAETALHKKNEIVNSVQAKGDQLTSALKQIEERLQKSEKTREAAEENCNKMKMEHGAKIGSLQQQLEKL N--------------KTCAVLEKDLKSEKEKHDTLQDKLH---------------KEKETATSLRN--ELHQFSLLQKNF DNLHQEK------------KQLQRLCEEQEQALQEMGQHLSQSKLKMEDIKEVNKALKG-HTWLKDDE------------ ------ATECKQCNKEFSISRRKHHCRNCGDIFCNSCSSNELSLPSYPKPVRVCDICHNLLLQRCSSNSS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Danio_rerio_RUFY1a ------------------------------MADEDPNTKVESGD------------------------------VPAKEE EPEVTETGQEDVANNTDELQKDR-----------PADSSWSAPILSFARKATET------------LSS--GVNHYSAGL KT-------PDTTQQHSSDPVKIAAVKDP--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --VVVERSNLLSMMK-----------------LSIKVL------IQSSLSLGRTLDSEYPPLQQFFVVLEHCLKHGLK-- --------------------VRKSFIGLQNKSIWAPLEMIEKLC------------------------------------ ------------------PESADIATSVRDMPG-IKTGLGRA-------------------------------------- ------------------------------RAWLHLALMQKKIADYMKVLINRRDLL---------------------GE FYEPGALVMEEEGAVIVG---------------------------------------------------------MLVGL NVIDAN----------------------------------------------------------LCVKGEDLDSQ-VCVI DFSMYLKDPQATESKQD--------------DSKMTAILDQKHYIEELNRHL-----------SCTVTDLQAKMDSLEKT NSKLIEELTAATD-RINALREEQEQLKQENANILQSSQRKEEVTLQDSQV---ELETYRQTRQGLDEMYS---------- -------VVWKQYKEEKRIRQELQKELELQIGLKQEMEVAMKLLEKDTHEKQDTLVALRQQLDQVKNLNLQMFNKAQ--- -----------ASDRVAQKKEEDMVHLEKKMIQMEAAMKELEQRLQNSEDVQKNTDEQQNEIRTEMKGKVNALQKRLSDL D--------------TLRAGLETELSAEKEQRQILQKELQ---------------REQDNSAELRT--QLQQLQGLQTEL LDLRQEK------------QQLQQLCEEQEQALQEMGLHLSQSKLKMEDFKEVNKALKG-HAWLKDDE------------ ------ATQCKQCQKEFSISRRKHHCRNCGDIYCGNCSSNELALPSYPKPVRVCDVCHSLLLQRSSTGS----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Takifugu_rubripes_RUFY1a -------------------------AEGANMADEAEEVNTPAED------------------------------GNTGQQ LQGTEVSEAEKNSQFCSSDRPDPGEK----PSPASTEHSWSAPLLSFARKATET------------ISS--GGAAASSPT NS-------LPENDINYTSHQPVVPFKDH--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MSIERSNLLSMMK-----------------LSIKVL------IQSSLSLGRTLDSEYPPLQQFFVVLEHCLKHGLK-- --------------------AKKSFIG-QNKSIWGPLELVERLC------------------------------------ ------------------PESANIATSARDLPG-IRTGLGRG-------------------------------------- ------------------------------RAWLHLALMQKKVADYMKALLDRKDLL---------------------SE FYEPGALMMEEEGVVMGG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCIKGEDLDSQ-VGVI DFSLYLKDPASSETPRD--------------DSKMTAILDQKHYIEELNRHL-----------SGTVTDLQAKMDSLEKT NSKLVEELTAATD-RINSLREEREKLQQENDSILQSSQKKEEAALQDSQV---ELETYKQTRQGLDEMYN---------- -------VVWKQYKEEKRIRQDLERELELQVGLKQEMEVAMKLLEKDTHEKQDTLAALRLQLDQVKTLNLQMFQKAQ--- -----------DSEQEAERKHAKAVQLEQRMNDMEKVIMELEQRLENSEQEHKESDQSDKDMKMELEGKVDALQKQLTDL D--------------TLRLGLENDLRAEREQRQSLQKSLQ---------------REQDNSGELRT--QLQQLQGLHEEL RSLKEEK------------QQLQQKCELQEQTLQEMGLHLSQSKLKMEDFKEVNKALKG-HAWLKDDE------------ ------ATHCKQCQKEFSIARRKHHCRNCGDIYCSSCSSNELALPSYPRPVRVCDVCHTFLLQRSSFGSS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Tetraodon_nigroviridis_RUFY1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------VPSKDP--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MSIERSNLLSMMK-----------------LSIKVL------IQSSLSLGRTLDSEYPPLLQFFIVLEHCLKHGLK-- --------------------TRKSFIG-QNKSIWGPLELVEKLC------------------------------------ ------------------PESANIATSARDLPG-IRTGLGRG-------------------------------------- ------------------------------RAWLHLALMQKKVADYMKALLDRKDLL---------------------SD FYEPGALMMEEEGVVMGG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCIKGEDLDSQ-VGVI DFSLYLKDPASSEPQRD--------------DSKMTAILDQKHYIEELNRHL-----------SGTVTDLQAKMDSLEKT NSKLVEELTAATD-RINSLREEQEKLRQENDSILQSSQKKEEVTDDDSQV---ELETYKQTRQG-DEMYN---------- -------VVWKQYKEEKHIRQDLERELELQVGLKQEMEVAMKLLEKDTHEKQDTLAALRLQLDQVKTLNLQMFKKAQ--- -----------DSEQEAERKEAKAVQLEQRMNDMEKVIVELEQRLQNSERERKQSDQSDRDMKLELEGKVDALQRQLTDL D--------------ALRLGLENSLRVEREQRQSLQKALQ---------------REQDNSVELRT--QLQQLQGLHEEL RSLKEEK------------QQLQQKCELQEQTLQEMGLHLSQSKLKMEDFKEVNKALKG-HAWLKDDE------------ ------ATHCKQCQKEFSIARRKHHCRNCGDIYCSGCSSNELALPSYPRPVRVCDMCHALLLQRSSFGSS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Gasterosteus_aculeatus_RUFY1a -------------------------------------------------------------------------------- ------------------AER-------------PAESGWSAPLRSLARKATET------------ISS--GVSYAAAQR ---------SLSTGSAASAPGDFVPPKDP--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MAIERSNLLSMMK-----------------LSIKVL------IQSSMSLGRTLDSEYPPLQQFFIVLEHCLKHGLK-- --------------------AKKSFIG-QNKSIWGPLELVEKLC------------------------------------ ------------------PESVNIATSARDLPG-IKTGLGRG-------------------------------------- ------------------------------RAWLHLALMQKTVADYMKALLDRKDLL---------------------SE FYDSGALMVEEEGAVMGG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCIKGEDLDTQ-VGVI DFSLYLKDPAKSETPKD--------------DTKMTAILDQKHYIEELNRHL-----------SGTVTDLQAKMDSIEKT NSKLVEELTAATD-RINSLREEQEQLRKANETILQCTQKKEEAALQDSQV---ELETYKQTRQGLDEMYN---------- -------VVWKQYKEEKRIRQELEHELELQVGLKQEIETAMRLLEKDTHEKQDTLEALRLQLDQVKTLNLQMFHKAQ--- -----------ASDRVAERKQTEAAQLEGKMDEMERAMMDLEQRLQHSEQQRKHSDQSDEDMREELEGKVEALQKQLTDL D--------------TQRLGLETELRTEREHRQSLQKALQ---------------QEQDNSTELRT--QLQQLQGLQAEV QDLKHEK------------RQLQQTCGQQEQALQEMGLHLSQSKLKMEDFKEVNKALKG-HAWLKDDE------------ ------ATQCKQCEKEFSIARRKHHCRNCGDIYCNSCSSNELALPSYPRPVRVCDACHALLLQRSSSTGC---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Oryzias_latipes_RUFY1a -----------------TGTTARCRSRSRDEVLGQVQSRDEPEM------------------------------SQRQDP QPGVGEEDSEAFEELSDRAEQDAAGK----SPSVAAENSWSAPIFSLARKASET------------ISH--GMSYAAAPR ---------KLSHGSSASS---FLPPKDP--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MGIERSNLLSMMK-----------------LSIKVL------IQSSLSLGRTLDSEYPPLQQFFVVLEQCLKHGLK-- --------------------TKKSFIG-QNKSIWGPLELVEKLC------------------------------------ ------------------PESANIATSARDLPG-IRTGLGRG-------------------------------------- ------------------------------RAWLHLALMQKKIADYIKALLDHKDLL---------------------SE FYDSGAMMLEEEGSVLGG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCIKGEDLDSQ-VGVI DFSLYLKDPASSETPKD--------------DANMTAILDQKHYIEELNRHL-----------SGTVTDLQAKLDSIEKT NSKLVEELTAATD-RINSLQDEQEQLKKENESILQCSQKKEEAALQDSQV---ELETYKQTRQGLDEMYN---------- -------VVWQQYKEEKRIRQELQRELELQVGLKQEMEVAMKLLEKDSHEKQDTLAALRLQLEQVKTLNLQMFHRAQ--- -----------ESERQAEKKQEEAVKLEQRMKDMEKAMEEMEQRLQNSECERKQSDQSDEDMKVELEGKVDALQTQLTDL D--------------TLRLGLENELRTEREQRQSLQKALQ---------------REQDNSSELRT--QLQQLQGLHVEL QELKQEK------------QQLQERCEQQEQALQEMGLHLSQSKLKMEDFKEVNKALKG-HAWLKDDE------------ ------ATQCKQCQKEFSIARRKHHCRNCGDIYCNSCSSNELALPSYPRPVRVCDVCHALLLQRSSSTAS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Strongylocentrotus_purpuratus_RUFY1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------DSVIK NPVLVERANLLNVAK-----------------LCIKTL------IESAMEEARILDDEYVPLQQFFVVLEHVMNHGVK-- --------------------GKKTFLE-KKRSFWGAVESLEKSL------------------------------------ ------------------PDFAEIIDSVRNLPG-IKTSIGRG-------------------------------------- ------------------------------RAWLRLAMMQKKLADYFKAIIESK-HL--------------------LSE WYEPTALVMEEESMVIAG---------------------------------------------------------LLVGL NAIDCN----------------------------------------------------------FCLKGDDLDSA-PSVI DFSMYFKDELNVXTNKVID-----------RNVVLSALLDQKNYLEEHNRHLT-----------SQITGLHTRIKALEEA NASMKGEHAMANN-NILSIQAENDLLRAENNTLKQHTD---------------RKLEMVKADIETERETYN-----TSRQ GLNEMYSEAKQRLQQETQMRLDVEQELQLQISLKMEMEMAMRLLEKDIHEKQDTIISLRKQLEDIKSMNIDLYKKIQ--- -----------GTEETMKHKSVLVGKLEEKTNQMVDTIKQLEERLRSVEREKQA-----------CAETARKLGMQIAER D--------------IKCSNMAADLKVEGEWRATLQKEIA-----------------QEKELISQLQAEVADVRSLREQL ATLLGKH------------EELGKTCHEQELALTEMGSKLSDSQLKMDSMKELVQSAEGR-------------------V WADDRDAKNCLTCDKPFSVARRKHHCRNCGGIYCGPCSDNLMPLPSSAKPVRVCDHCNTELLQRYSATSR---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Homo_sapiens_RUFY2 -------------------------------------------------------------------------------- --------------------------------------------------------------------MTFQVWGWRRED ASQVLAWVPDAEGGRRGMLTRRSLATKDP--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --TAVERANLLNMAK-----------------LSIKGL------IESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLK-- --------------------VRKSFLS-YNKTIWGPLELVEKLY------------------------------------ ------------------PEAEEIGASVRDLPG-LKTPLGRA-------------------------------------- ------------------------------RAWLRLALMQKKMADYLRCLIIQRDLL---------------------SE FYEYHALMMEEEGAVIVG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCVKGEDLDSQ-VGVI DFSMYLKNE-EDIGNKE-R------------NVQIAAILDQKNYVEELNRQL-----------NSTVSSLHSRVDSLEKS NTKLIEELAIAKN-NIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVET---ELQTYKHSRQGLDEMYN---------- -------EARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQ--- -----------GSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQK E--------------KQLVQLETDLKIEKEWRQTLQEDLQ---------------KEKDALSHLRN--ETQQIISLKKEF LNLQDEN------------QQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQG-LVWLKDKE------------ ------ATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSCHALLIQRCSSNLP---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Callithrix_jacchus_RUFY2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------ATKDP--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --TAVERANLLNMAK-----------------LSIKGL------IESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLK-- --------------------VRKSFLS-YNKTIWGPLELVEKLY------------------------------------ ------------------PEAEEIGASVRDLPG-LKTPLGRA-------------------------------------- ------------------------------RAWLRLALMQKKMADYLRCLIIQRDLL---------------------SE FYEYHALMMEEEGAVIVG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCVKGEDLDSQ-VGVI DFSMYLKNE-EDIGNKE-R------------NVQIAAILDQKNYVEELNRQL-----------NSTVSSLHSRVDSLEKS NTKLIEELAIAKN-NIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVET---ELQTYKHSRQGLDEMYN---------- -------EARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQ--- -----------GSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQK E--------------KQLVQLETDLKIEKEWRQTLQEDLQ---------------KEKDALSHLRN--ETQQIISLKKEF LNLQDEN------------QQLKKIHHEQEQALQELGNKLSESKLKIEDIKEANKALQG-LVWLKDKE------------ ------ATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSCHALLIQRCSSNLP---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Mus_musculus_RUFY2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MATKDP--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --TAVERANLLNMAK-----------------LSIKGL------IESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLK-- --------------------GRKSFLS-YNKTIWGPLELVEKLY------------------------------------ ------------------PEAEEIGASVRDLPG-LKTPLGRA-------------------------------------- ------------------------------RAWLRLALMQKKMADYLRCLIIQRELL---------------------SE FYEYHALMMEEEGAVIVG---------------------------------------------------------LLVGL NVIDAN----------------------------------------------------------LCVKGEDLDSQ-VGVI DFSMYLKNE-EEIGNKE-R------------NVQIAAILDQKNYVEELNRQL-----------NSTVSSLHSRVDSLEKS NTKLIEELAIAKN-NIIKLQEENHQLRSENELILMRTRQHLEVTKVDVET---ELQTYKHSRQGLDEMYN---------- -------DARRQLRDESQLRQDVENELSVQVGMKHEMELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQRLQ--- -----------GSEDGLKEKNEIIARLEEKTNKITTAMRQLEQRLQQAEKAQKEAEAEDEKYAQECLSQSDSLQRQISQK E--------------QQLVQLETDLKIEKEWRQTLQEDLQ---------------KEKDVLSHLRH--ETQKVISLKKEF LNLQDEN------------QQLKRIYQEQEQALQELGSKLCESKLKIDDIKEANKALQG-LVWLKDKD----------