>Homo_sapiens_RHOH -------------------------------------------------------------------------------- ----------------MLSSIKCVLVGDSAVGKTSLLVRFTSE-----------TFPEAYKPTVY--ENTGVD------- --VFMDGIQISLGLWDTAG--------------------------NDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKN KWIGEI------------RSNLPCTPVLVVATQTDQREMGPHRASCVN----------------------------AMEG KKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARR-----------------RNRR------------------- ---------RLFSINECKIF------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Pan_troglodytes_RHOH -------------------------------------------------------------------------------- ----------------MLSSIKCVLVGDSAVGKTSLLVRFTSE-----------TFPEAYKPTVY--ENTGVD------- --VFMDGIQISLGLWDTAG--------------------------NDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKN KWIGEI------------RSNLPCTPVLVVATQTDQRETGPHRASCVN----------------------------AMEG KKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARR-----------------RNRR------------------- ---------RLFSINECKIF------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Mus_musculus_RHOH -------------------------------------------------------------------------------- ----------------MLSSIKCVLVGDSAVGKTSLLVRFTSE-----------TFPEAYKPTVY--ENTGVD------- --VFMDGIQISLGLWDTAG--------------------------NDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKN KWISEI------------RSNLPCTPVLVVATQTDQREVGPHRASCIN----------------------------AIEG KRLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARR-----------------RNRR------------------- ---------KLFSINECKIF------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Gallus_gallus_RHOH -------------------------------------------------------------------------------- ----------------MLDSIKCVLVGDSAVGKTSLLVRFISD-----------TFPDNYRPTVY--ENTGVD------- --VFMDGVQISLGLWDTSG--------------------------SDAFKGIRPLSYQQADVVLMCYSVANHNSFLNLRS KWIGEI------------RNHLPRIPVLVVATQTDQRDTGPYRSSCIS----------------------------SMDG KRLAQDVRAKGYLECSALSNRGVQQVFEYAVRTAVNQAKR-----------------QNRR------------------- ---------KLFSINECKIF------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Xenopus_tropicalis_RHOH -------------------------------------------------------------------------------- ----------------KMNSIKCVLVGDAAVGKTALLVRFTSE-----------AFPDSYRPTVY--ENTGVD------- --VYMDGVQISLGLWDTAG--------------------------NDAFRSIRPLSLQNADIVLLCFSVANHTSFLNVRN KWIGEV------------RQHLPRIPVLVVATQTDQRELDHMRLPCIN----------------------------SIDG KQLAQDVRAKGYLECSALSNRGVQQVFECAVRTAINQAKK-----------------RARR------------------- ---------HRFLSQECKIF------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Takifugu_rubripes_RHOH_a -------------------------------------------------------------------------------- ------------------MSIKCVLVGDNAVGKTALLVRFTSE-----------TFPESYRPTVF--DNTGVE------- --VYMDGVHISLGLWDTAG--------------------------NDTFQQIRPRSYQQADIVLICYSVANPNSLANVHK KWLPEV------------REHLPNVPVLVVATQTDLREMGAYRGNCTT----------------------------SAEG AQMAREIKAKGYVECSAFSNRGVQQVFEYAVRIVVNQAKK-----------------QARR------------------- ---------RMFRINQCKVF------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Tetraodon_nigroviridis_RHOH_a -------------------------------------------------------------------------------- ------------------MSVKCVLVGDSAVGKTALLVRFTSE-----------TFPESYRPTVF--DNTGVE------- --VYMDGVHISLGLWDTAG--------------------------NDNFQQIRPRSYQQADIVLICYSVANPNSLANVQN RWIPEV------------RQNLPKVPVMVVATQTDLREMGAYRGNCIT----------------------------AAEG AQVAREIKAKGYVECSAFSNRGVQQVFEYAVRIAVNQAKK-----------------QARR------------------- ---------RMFSINQCKVF------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Anopheles_gambiae_RHOH -------------------------------------------------------------------------------- -------------MSS-GRPIKCVVVGDGTVGKTCMLISYTTD-----------SFPGEYVPTVF--DNYSAP------- --MVVDGVQVSLGLWDTAG--------------------------QEDYDRLRPLSYPQTDVFLICYSVASPSSFENVTS KWYPEI------------KHHCPDAPIILVGTKIDLREDRETISLLAD---------------------QGLSALKREQG QKLANKIRAVKYMECSALTQRGLKQVFDEAVRAVLR-PEP-----------------LKR-------------------- ------------RQRKCVVM------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Homo_sapiens_RHOBTB2 ---------------------------------------------------------------MQAWRKGPDGPQKTSSD SMSRLMDSDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER SRDVVDDVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKT MWYPEIKH------------FCPRAPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKPNEILPPEKG REVAKELGIP-YYETSVVAQFGIKDVFDNAIRAALISRRH-LQFWKSHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSS EECPAHLLEDPLCADVILVLQE-RVRIFAHKIYLSTSSSKFYDLFLMDLSEGELGGPSEPGGTHPEDHQGHSDQH--HHH HHHHHGRDFLLRAAS-FDVCESVDEA---------------------------------------------G-GSGPAGL RAST-----SDGILRGN----GTGYLPGRGRVLSSW-----------------------SRAFVSIQEE-MAEDPLTYKS RLMVVVKMDSSIQPGPFRAVLKYLYTGELDENERD---LMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRR TNRVKECLA-KGTFSDVTFILDDGTISAHKPLLISSCD-WMAAMFGGPFVESSTREVV-FPYTSKSCMRAVLEYLYTGMF T---SSPDLDDMKLIILANR-LCLPHLVALTEQYTVTGLMEATQM-MVDIDGDVLVFLELAQFHCAYQLADWCLHHICTN YNNVCRKFPRDMKAM-SPENQ----EYFEKHRWPPVWYLKEEDHYQRARKEREK----------------EDYLHLKRQP KRRWLFWNSPS---SPSSSAASSSSPSSSSAVV----------------------------------------------- ---------------- >Pan_troglodytes_RHOBTB2 -------------------------------------------------------------------------------- -----MDSDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER SRDVVDDVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKT MWYPEIKH------------FCPRAPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKPNEILPPEKG REVAKELGIP-YYETSVVAQFGIKDVFDNAIRAALISRRH-LQFWKSHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSS EECPAHLLEDPLCADVILVLQE-RVRIFAHKIYLSTSSSKFYDLFLMDLSEGELGGPSEPGGTHPEDHQGHSDQQ--HHH HHHHHGRDFLLRAAS-FDVCESVDEA---------------------------------------------G-GSGPAGL RAST-----SDGILRGN----GTGYLPGRGRVLSSW-----------------------SRAFVSIQEE-MAEDPLTYKS RLMVVVKMDNSIQPGPFRAVLKYLYTGELDENERD---LMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRR TNRVKECLA-KGTFSDVTFILDDGTISAHKPLLISSCD-WMAAMFGGPFVESSTREVV-FPYTSKSCMRAVLEYLYTGMF T---SSPDLDDMKLIILANR-LCLPHLVALTEQYTVTGLMEATQM-MVDIDGDVLVFLELAQFHCAYQLADWCLHHICTN YNNVCRKFPRDMKAM-SPENQ----EYFEKHRWPPVWYLKEEDHYQRARKEREK----------------EDYLHLKRQP KRRWLFWNSPS---SPSSSAASSSSPSSSSAVV----------------------------------------------- ---------------- >Mus_musculus_RHOBTB2 -------------------------------------------------------------------------------- -----MDSDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER SRDVVDDVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKT MWYPEIKH------------FCPRAPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKPNEILPPEKG REVAKELGIP-YYETSVVAQFGIKDVFDNAIRAALISRRH-LQFWKSHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSS EECPAHLLEDPLCADVILVLQE-RVRIFAHKIYLSTSSSKFYDLFLMDLSEGELGGPSGSGGPRPEDHRSHPEQH--HHH HHHHHGRDFLLRAAS-FDVCESVDEA---------------------------------------------G-GSGPAGL RAST-----SDGILRGN----GTGYLPGRGRVLSSW-----------------------SRAFVSIQEE-MAEDPLTFKS RLMVVVKMDNSIQPGPFRAVLKYLYTGELGENERD---LMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRR TNRVKECLA-KGTFSDVTFILDDGTISAHKPLLISSCD-WMAAMFGGPFVESSTREVV-FPYTSKSCMRAVLEYLYTGMF T---SSPDLDDMKLIVLANR-LCLPHLVALTEQYTVTGLMEATQM-MVDIDGDVLVFLELAQFHCAYQLADWCLHHICTN YNNVCRKFPRDMKAM-SPENQ----EYFEKHRWPPVWYLKEEDHYQRARKEREK----------------EDYLHLRRQP KRRWLFWNSPS---SPSSSAAGSASPSSSSSAVV---------------------------------------------- ---------------- >Xenopus_tropicalis_RHOBTB2 ------------------------------------------------------------------------------CL IRSQLLDTDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER SRDVVDDVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLQHVQT MWYPEIKH------------FCPRAPVILVGCQLDLRYADLEAVNRA----RRPLAS---------RPIRPQEILPPEKG REVAKELGIP-YYETSVVAQCGIKEVFDNAIRSALISRRH-LQFWKSHLRSVRRPLPQAPFLPPRPPPPVIIVPDPPTKS EDHPARLLEEASCADVVLVVQE-RIRIYAHRIYLSTASSKFCDLFLMEDGDSP--------------------------- ---TQTRDPLLRASS-FDACEVSGES---------------------------------------------E----GAGM RASA-----SDGTLGRE-----------CGRDLSSW-----------------------SRAFESIHSG-VLEEPPGYRA RRVAVVKMDSSVRPGPFRAVLKFLYTGRLDEREPD---LMEVAHIAELLEVFDLRMMVANILNREAFMNQEITRAFHVRR SNRVKECLA-KGTFSDVTFMLDDGSIKAHKPLLISGCD-WMAAMFGGPFLESSTTEVV-IPYTSRGSMRAVLEYLYTGQF SYRISSTNPLDCKHTQTAIG-YPLPHLVALTEQHTVSVMLDASLN-NKDIDGEALMLLEAAQFHGADQLAAWCMHHISTN YNRVCRKFPRDIKAV-SAENQ----QALETQRWPPVWYLKEEDHFQRAQREREK----------------ETALHQKRQP KRRWLFWNNSR--------AGSSATPTPSSSAV----------------------------------------------- ---------------- >Danio_rerio_RHOBTB2_a --------------------------------------------------------------------------MHPFSS LRSQFTDTDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER SRDVVDDVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLFHVKT MWYPEIKH------------FCPRAPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKANEILPPEKG REVAKELCVP-YYETSVVAQFGVKDVFDNAIRAALISRRH-LQFWKSHLRDVQRPLLQAPFLPPKPPPPVITVPPAPSPT DEHPGRLLEEPLCADVLLVLQE-HHRVFAHKVYLATASSKFYDLFVQDSVLGR-ESPAQADSFDIEN------------- ----------STSHQ-HPVSESIDED---------------------------------------------S----TVKM RACI-----SDGTLTND----APLEMSHGGRLSSAL-----------------------GRAFISMRRE-SVQDPVTLVS RPMTVVHLDPSVLFGPFAVVLRYLYTGRLDENEKD---LMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRR TNRVKECLA-KGTFSDVVFQLDDGTVEAHKPLLISSCD-WMAAMFGGPFVESSTKEVL-FPNTSRSSMQAVLEYLYTGRF C---SRPDLDTMELIILANR-LCLPHLVALTELHTVTVLKESAAA-GTDIDGDVLLYLEMAQFHCAEQLTSWCLHHICTN YNNVCRKFPRDMRAK-SAENQ----EYFEKQRWPPVWFLKEDDHYQRALKERQQ----------------EDSLNLKRQS RRRWTLRSIQSP--APPSSPSSSPSSSGSSAII----------------------------------------------- ---------------- >Danio_rerio_RHOBTB2_b -------------------------------------------------------------------------------- -----MDIDTDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER SRDVVDEVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSLANPNSLRHVRT MWFPEIKH------------FCPRTPIILVGCQLDLRYADLDAVNRA----RRPLA----------KPIKPTDILPPERG HEVAKELGVP-YYETSIVAQFGVKDVFDNAIRAALISRRH-LQFWKSHLKKVQRPLLQAPFLPPRPPRPVVGIPDPPPAD GEAPDSLFCQPLCADVLFLLQAGTTRVFAHKVYLATSCSKFYDLFTMDLG-----AAG-MENEHEESSEGSEEEEQ---- -SRRGAKEQAGRTKS-LDIEKEG-DG---------------------------------------------GTRGANRLL MLQQGSLRTSQSDNALPAKGQYSAGTLGAGRALLGW-----------------------GRGFLGVYLE-MVDDPVTGRP RLMTVVSMDDLIQKGPFQAVLQYLYTGHLDERRGD---LMQVATIAELLEVFDLRMMVANVLNRESFMNQEITKAFHVRR ANRIKECLS-KGTFADVVFQLDDGYLPAHKPLLISSCD-WMAAMFRGSFMESYIEEVS-IPNTSCACMRAVLEFLYCGVL T---PSSELEPMDLIILANR-LCLPRLVALTEQHAVEDLLQLSVK-GLDIDGHVLAYLEMAQFHNAKQLSAWCLHHICTN YNSVCRKFPKDMKIM-SPENQ----KHFEKYRWPPVWFLKEEDRYLRSQKERER----------------EEEILRKQHT KRGWCFWRHPS------SSAPHIS-------------------------------------------------------- ---------------- >Takifugu_rubripes_RHOBTB2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------VS----------RPIKSNEILPPERG REVAKELGVP-YYETSVVAQFGVKDVFDNAIRAALISRRH-LQFWKSHLRNVQRPLLQAPFLPPKPPPPLITVPPPPTTT EEHPVGLLEDPHCADVILVLQE-RQKIFAHKIYLATSSSKFYDLFILDVQNAASERPA---------------------- RAPLSGRELLMRAAS-FDVCESNDDG---------------------------------------------D----RANL RACT-----SDGTLKDF-------EGSRRGRMLSSW-----------------------SRAFVSIQEE-LVEDPVTYGP RPMTVVHMDQSMQLGPFRAVLRYLYTGQLDENEKE---LMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRR TNRVKECLA-KGTFSDVVFKLDDGTIMAHKPLLISSCD-WMAAMFGGPFVESCTKEVL-FPNTSRSSMRAVLEYLYTGRF C---SRPDLDAMELIVLANR-LCLPHLVALTELYTVTVLTEAAMM-GPNIDGDVLLYLDMAQFHGAQQLTGWCLHHICTN YNSICRKFPRDMKAK-SADNQ----EYFEKHRWPPVWYLKEDDHYQRARRERDK----------------EDYLYQRRQC KRKWLFWNLPS---SPSSHSPSSGSSAVI--------------------------------------------------- ---------------- >Takifugu_rubripes_RHOBTB2_b ------------------------------------------------------------------------------LF SRALSMDIDTDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER SRDVVDEVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSLANPNSLRHVRT MWFPEIKH------------FCPRTPIILVGCQLDLRYADLDAVNRA----RRPLA----------KPIKPTDILPPERG HEVAKELGIP-YYETSIVAQFGVKDVFDNAIRAALISRRH-LQFWKSHLKKVQRPLLQAPFLPPRPPRPIIGIPDPPPTD GEGPDSLFCQPLCADVLFLLQAGSTRVFAHKVYLATSCSKFYDLFTLDLGGSFVVQKG-EDEENKENFESGEEDEQ---- -SRRGAKEQAGRTKS-LDIDKDGVDG---------------------------------------------GVRGLNRPQ LLQQGSLRTSQSDNALPSRAIYSLGALGTGRALSGW-----------------------GRGFLSVCLE-HVDDPVTGRP RLMTVVAMDALIQEEPFKAVLQYLYTGSLDEGRGD---LMQVATIAELLEVFDLRMMVANVLNRESFMNQEITKAFHVRR ANRIKECLN-KGTFADVVFRPDDGCLPAHKPLLISSCN-WMAAMFRGSFMESYIEEVP-IPNTSTACMRGVLEFLYSGLL T---PCPGLEPMELIVLANR-LCLPRLVALTEQHAADELLQLAVK-GGDIDGQVLAYLEVAQFHNAKQLSAWCLHHICTN YNSICRKFPKDMKAM-SSENQ----RHFEKHRWPPVWFLKEEDRYLRSQKERER----------------EEEILRKQHT KRGWCFWRHPS------S-------------------------------------------------------------- ---------------- >Tetraodon_nigroviridis_RHOBTB2_a ------------------------------------------------------------------------------IF SRALSMDIDTDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YRLP-RDVPTVWAIDQYRVCQEVVLER SRDVVDEVSVSRRVWDTFW----------------------------RSSQEHRFSPSRSDVVVLCFSLANPNSLRHVRT MWFPEIKH------------FCPRTPIILVGCQLDLRYADLDAVNRA----RRPLA----------KPIKPTDILPPERG HEVAKELGIP-YYETSIVAQFGVKDVFDNAIRAALISRRH-LQFWKSHLKKVQRPLLQAPFLPPRPPRPIIGIPDPPPVD GEGPDSLFCQPLCADVLFLLQS-SIRVFAHKVYLATSCSKFYDLFTLDLGGSCVVQQR-EEDENKENFESGEEDEQ---- -SRRGAKEQAGRTKS-LDIDKDGVDG---------------------------------------------GVRGLNRPQ LLQQGSLRTSQSDNALPSRAIYSVGALGTGRTLLGW-----------------------GRGFLSVCLE-HVDDPVTGRP RLMTVVAMDALIQEEPFKAVLQYLYTGSLDEGRGD---LMQVATIAELLEVFDLRMMVANVLNRESFMNQEITKAFHVRR ANRIKECLN-KGTFADVVFRPDDGCLPAHKPLLISSCN-WMAAMFRGSFMESYIEEVP-IPNTSTACMRGVLEFLYSGLL T---PCPGLEPMELIVLANR-LCLPRLVALTEQHAADELLQLAVK-GGDIDGQVLAYLDVAQFHNAKQLSAWCLHHICTN YNSICRKFPKDMKAM-SSENQ----RHFEKHRWPPVWFLKEEDRYLRSQKERER----------------EEEILRKQHT KRGWCFWRHPS------S-------------------------------------------------------------- ---------------- >Tetraodon_nigroviridis_RHOBTB2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------EILPPERG REVAKELGVP-YYETSVVAQFGVKDVFDNAIRAALISRRH-LQFWKSHLRNVQRPLLQAPFLPPKPPPPIITVPPPPTTT EEHPVGLLEDPHCADVILVLQE-RQKIFAHKIYLATSSSKFYDLFIMDMQNEESDRPI---------------------- RGPLSGRELLMRAAS-FDVCESSDDG---------------------------------------------D----RANL RACT-----SDGTLKDF-------EGGRRGRVLSSW-----------------------SRAFVSIQEE-LVEDPVTYSP RPMTVVHMDQSMQLGPFRAVLRYLYTGQLDENEKE---LMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRR TNRVKECLA-KGTFSDVVFKLDDGTIMAHKPLLISSCD-WMAAMFGGPFVESCTKEVL-FPNTTRSSMRAVLEYLYTGRF C---SRSDLDAMELIVLANR-LCLPHLVALT-----------------------------AQFHGAQQLTGWCLHHICTN YNSICRKFPRDMKAK-SADNQ----EYFEKHRWPPVWYLKEDDHYQRARKERDK----------------EDYLYQRRQC KRKWLFWNLPS---SPNSH------------------------------------------------------------- ---------------- >Branchiostoma_floridae_RHOBTB2 -------------------------------------------------------------------------------- -------MALLNQRPHLVELVKCVVVGDNAVGKTRLICARACATPITK-----QQLLATHVPTVWAIDQYQISPQI-LER SYDIVDGVHVSLRLWDTFG----------------------------DHEKDRRFAYGRSDVVLLCFSIANPTSLKHAML MWYPEIKQ------------FCPHAPIILAGCQADLRYADLDLYNKH----KGPFA----------RKVKPSDIMMPDEG RSVAKELGIP-YYETSIVDNYGIRDLFHNVTRAALLARRS-FLFWKSNLKKVQKPLLQLPFLPPPPPLPIITVP--LNTH VEELRDFFHNPGCSDVTFLAQG--VRIPANKVFLVAASPFFKDLFMMDLS------------------------------ ------QDLANQTHLDNDPCKDKGLS---------------------------------------------RTTNLHVTK SQLG-----GQGDVNGNG---TTDFHGFPSHILEHS-----------------------VIHSIHLANQ-SDPFVESERP TLHTFVTLNPSVLPKAFQHCLEFLYTGHLEEKGLP---LTEMLHLAKELQMVVLVEMVRNHLNEEEFMNSEVTFRFHKRR NSGLKDMLS-KGLLSDVVFRVDDGTVTAHKPLLMAHCD-VMSAMFGGNFLESSIKEVP-LPGTTKACLQALLEYLYTGQL S---LPANRDCIGLIELANR-ICLPRLVALTEHHIVLELSRAREN-NQDIHLEVLMLLEPAQLHNACQLSAWCVSHITTN YKHICRRYSKELHTL-TPETQ----QYVAKHRWPPIWYLKERDYYDKAQRERERAEE-------------KKAALQKVKR VKKWCF-------------------------------------------------------------------------- ---------------- >Strongylocentrotus_purpuratus_RHOBTB2 -------------------------------------------------------------------------------- ---------MDNELPR-QELVKCVVVGDSAVGKTRLIVARATNQAMTR-----SQLFQTHIPSVWAIDQYRMCQEV-LEN SWETIDGVSVSLRLWDTFG----------------------------DHEKDRQFAYGRADVVLLCFSIADAISLKNVKK KWLPEIRH------------FCPRAPIIMCGCKNDLRYADLEALKKE----RGPVSHQCS----RHRAFDPEGILPPKEG RNIAKESNLV-YYETSSYTLYGVQEVFDNVVRAALIYRRQ-HRFWQSNLKKVQKPLLQAPYLPGCPRGPCIHIPESTYAT --DISILLKEPACADVIFTAHG--ESICAHKVCLLAASPIFSELFLDDEKDIELSKQS--SSSGSNSSNENQSQAKDILQ QHHHHTAHQSPRSESPMCCHSPTPDRSQSPDCNHENICPSPPLGLHPNCNTLLAEDQCLSISPNGNTCLFSGSAQHKNCS KAAPTTMGSSSPLHHHHQQTSTPTRLRSSSPSIRSSPLQQINTPTVPANLQCLPTKTLKHQAFNSIHLQ-QVTDSLGGRT TQRHIVVLNPKITAEAFRAVLEFLYTGSLDIKVYSS--LSDIITAASLLDLSDLVAFVANVKNQDEFLNADLVDNFLHRR KERFAKLFANQGLLSDLVINVEDGQVKSHKCLVMVRCD-PMLAMLSGNFKESS-SEVS-MKTFKKATFELFLEYLYTDQC H---MESNSDALAVLELANF-LCLPHLVALCEKSVVHELQSSMET-QDVLDEAVVSVLQIAKLHNAHQLHSWCIHYMTIR FIDVQKGRPKLFKEL-APEYR----KQIERQRWPPAYYLDEAAYFEKCLAELKK-------------------GNDIRTK KHKWCLR------------------------------------------------------------------------- ---------------- >Hydra_magnipapillata_RHOBTB2 ----------------------------------------------------------------------------MDID SWPASSNSFDAYDNKPSEEFIKCVVVGDTAVGKTRLICSYIFDQPPTS---IQSLHLKPHIPTVFAIDQYVGNSDI-RKR GKTVIDGVNVELRIWDTFG----------------------------DHEKDRKYAYENAHVVVVCFSIGMQSSLINVNA KWVPEIKK------------YCPRAAIVLVGTQLDRRYTNPEMYKNALQVTTLTNILNTGGRFKLHSGFSMSDIIYAETA RQISKEIKAACYIEVSVVSKHGVNAVFENSIRAALILRRNSKLILKSHLKNIKTPHIQEPYLPPCPEAPDINILAEGEMF DFSCLHSVSS--FCDIEFIVEN--EHLHAHSVVLISADEVFQSLLMHPFILDLLG------------------------- --FPKGKNIQNFESFSLEYAPING-------------------------------------------------------- ------------------------------------------------------------VLCYGIPRGFSSISVVTDFN LKRKVTVNVSQVTAVSFRNILEFVYCGSISNIKDS----AQLLTNATYLQLSMLCNYLTSSIEESSQLKNTFYQMLFKKR KKILLNFVFNKSLYSDISFSMEGALIPSHKPLLVVQCN-VMAGMFRKKTFKESITHVVDFSNCDKESFMTVLEYLYTCDL CN-----HGDLHNVLQLANF-LCLPRLITLCELELTKKITEVNSNQCDEACALVLDTFIFAKFHNAVQLSDWCLYFMASN YNKMCQYQGREMKALDETTKN-----YLEKNRWPPVWYLKDQDLYERCMQKIEK----------------ENTFKISKER KESRCFSFFKNL-------------------------------------------------------------------- ---------------- >Homo_sapiens_RHOBTB1 -------------------------------------------------------------------------------- -----MDADMDYERPN-VETIKCVVVGDNAVGKTRLICARACNTTLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER SRDVVDEVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKS MWYPEIKH------------FCPRTPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKRGDILPPEKG REVAKELGLP-YYETSVFDQFGIKDVFDNAIRAALISRRH-LQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPSMG TNEAACLLDNPLCADVLFILQD-QEHIFAHRIYLATSSSKFYDLFLMEC---------------EESPNGSEGACE---- -KEKQSRDFQGRILS-VDPEEEREE----------------------------------------------GPPRIPQAD QWKS----SNKSLV--EALGLEAEGAVPETQTLTGW-----------------------SKGFIGMHRE-MQVNPISKRM GPMTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKD---LVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRK ANRIKECLS-KGTFSDVTFKLDDGAISAHKPLLICSCE-WMAAMFGGSFVESANSEVY-LPNINKISMQAVLDYLYTKQL S---PNLDLDPLELIALANR-FCLPHLVALAEQHAVQELTKAATS-GVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTN YNSVCSKFRKEIKSK-SADNQ----EYFERHRWPPVWYLKEEDHYQRVKREREK----------------EDIALNKHRS RRKWCFWNSSP------AVA------------------------------------------------------------ ---------------- >Pan_troglodytes_RHOBTB1 -------------------------------------------------------------------------------- -----MDADMDYERPN-VETIKCVVVGDNAVGKTRLICARACNTTLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER SRDVVDEVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKS MWYPEIKH------------FCPRTPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKRGDILPPEKG REVAKELGLP-YYETSVFDQFGIKDVFDNAIRAALISRRH-LQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPSMG TNEAACLLDNPLCADVLFILQD-QEHIFAHRIYLATSSSKFYDLFLMEC---------------EESPNWSEGACE---- -KEKQSRDFQGRILS-VDPEEEREE----------------------------------------------GPPRIPQAD QWKS----SNKSLV--EALGLEAEGAVPETQTLAGW-----------------------SKGFIGMHRE-MQVNPISKRV GPMTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKD---LVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRK ANRIKECLS-KGTFSDVTFKLDDGAISAHKPLLICSCE-WMAAMFGGSFVESANSEVY-LPNINKISMQAVLDYLYTKQL S---PNLDLDPLELIALANR-FCLPHLVALAEQHAVQELTKAAMS-GVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTN YNSVCSKFRKEIKSK-SADNQ----EYFERHRWPPVWYLKEEDHYQRVKREREK----------------EDIALNKHRS RRKWCFWNSSP------AVA------------------------------------------------------------ ---------------- >Mus_musculus_RHOBTB1 -------------------------------------------------------------------------------- -----MDSDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNTTLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER SRDVVDEVSISLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKT MWYQEIKH------------FCPRTPVVLVGCQLDLRYADLEAVNRA----RRPLA----------RPIKRGDILPPEKG REVAKELGIP-YYETSVFDQFGIKDVFDNAIRAALISRRH-LQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSAG TSDAACLLDNPLCADVLFVLHD-EEHIFAHRIYLATSSSKFYDLFLMEC---------------EESPCWGGGAG----- -EEVPCRDFQGRTQS-LGSAEEGKE----------------------------------------------GPQRTPQAD PGAS----SGQDLP--ESLALQMEASGSEGHALSGW-----------------------SKGFVSMHRE-VRVNPISKRV GPVTVVRLDPSMQSGPFRTLLRFLYSGQLDEKEKD---LLGLAQMAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRK ANRIKECLS-KGTFSDVTFTLDDGAISAHKPLLICSCE-WMAAMFGGSFVESANREVH-LPNINKMSMQAVLEYLYTKQL S---PNLDLDPLELIALANR-FCLTHLVALVEQHAVQELTKAAVS-GVSIDGEVLSYLELAQFHNANQLAAWCLHHICTN YNSVCSKFRKEIKSK-SADNQ----EYFERHRWPPVWYLKEEDHYQRVKREREK----------------EDLALNKHHS RRKWCFWHSSP------AVA------------------------------------------------------------ ---------------- >Gallus_gallus_RHOBTB1 -------------------------------------------------------------------------------- -----MDIDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNTTLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER SRDVVDEVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKT MWYQEIKH------------FCPRTPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKRGDILPPEKG REVAKELGIP-YYETSVFDQFGIKDVFDNAIRAALISRRH-LQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPVPS VNEAGYLLDSPLCADVMFVLQE-QDCIFAHKIYLATSSSKFYDLFLMEC---------------EESSDLGETQCN---- -KENTSKDVLTS--HLETNYDSDE------------------------------------------------ISLKSADV KIPA----S-ESTDSLNMLKPEPAETISAARSLSSW-----------------------GKGFVSVHKE-MQVNPVSNRL CPVTVVKMDSSVQAGPFKTVLQFLYTGQLDENEKD---LTRLAQIAEILEVFDLRMMVENIMNKEAFMNQEITKAFHVRK ANRIKECLC-KGTFSDVTFKLDDGTINAHKPLLICSCE-WMSAMFGGSFIESLNSEVV-LPNINKTSMQAVLDYLYTKQL S---STQELDILELIALANR-FCLPHLVALAEQHAVQELTKASMS-GIAIDGDVLSCLELAQFHNANQLAAWCLHYICTN YNSVCSKFRKEIKAK-SSDNQ----EYFERHRWPPVWYLKEEDHYQRVKKEREK----------------EDFALNKHHS RRKWCFWNSSA------VVA------------------------------------------------------------ ---------------- >Danio_rerio_RHOBTB1 -------------------------------------------------------------------------------- ---------MDYERPN-VETIKCVVVGDNAVGKTRLICARACNTTLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER SRDVVDDVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKT MWYLEIKH------------FCPRTPVILVGCQLDLRYADLEAVNRA----RRPLS----------RPIKPGDILPPESG REVAKELGIP-YYETSVFDQFGIKDIFDNAIRAALISRRH-LQFWKSHLRRVQKPLLQAPFLPPKAPPPLIKIPECPAKN RDGPKQLLETPLCADVMFIVQE-HVHLYAHRIYLSTSSSKFFDLFQMDF---------------SDE---SQCLVV---- -TERHGRDQLMRTLS-LDTEEDVMV----------------------------------------------LPNLSPCSL RASK----SDGTLK----MMSFSGMHRRTRLSLASW-----------------------SKAFYSIHKE-NVINPVTGTP ALMTIVKMDHSIHHGPFSAVLRFLYTGELDEKEKD---LMKIAQIAEILEVFDLRMMVENIMNNEGFMNQEITKAFHVRK ANRIKECLA-KNNFTDVVFRLDDGTINAHKPLLISSCD-WMAALFGGSFMESANDEVS-FPNTSRVCMQAVLEYLYTNQL S---PMADLDPMELIALANR-LCLPRLIALTEQYAVSELLKASKD-GQDIDGEVLTYLELAQFHNANQLAAWCLHHICTH YNRICANYRKEIKSK-SPENQ----EYFEKHRWPPVWYLKEEDHYQRVKKEREK----------------EDVVLNKHHS RRRWCFWSTSP------AVA------------------------------------------------------------ ---------------- >Caenorhabditis_elegans_RHOBTB1 -------------------------------------------------------------------------------- -------------MQA----IKCVVVGDGAVGKTCLLISYTTN-----------AFPGEYIPTVF--DNYSAN------- --VMVDGRPINLGLWDTAG--------------------------QEDYDRLRPLSYPQTDVFLVCFALNNPASFENVRA KWYPEV------------SHHCPNTPIILVGTKADLREDRDTVERLRE---------------------RRLQPVSQTQG YVMAKEIKAVKYLECSALTQRGLKQVFDEAIRAVLTPPQR-----------------AKK-------------------- --------------SKCTVL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Homo_sapiens_RHOU -----------------MPPQQ--GDPAFPDR----------------CEAPPVPPRRERGGRGGRGPGEPGGRGR---- ------------AGGAEGRGVKCVLVGDGAVGKTSLVVSYTTN-----------GYPTEYIPTAF--DNFS---AV---- --VSVDGRPVRLQLCDTAG--------------------------QDEFDKLRPLCYTNTDIFLLCFSVVSPSSFQNVSE KWVPEI------------RCHCPKAPIILVGTQSDLREDVKVLIELDK---------------------CKEKPVPEEAA KLCAEEIKAASYIECSALTQKNLKEVFDAAIVAGIQYSDT-----------------QQQ-------PKKSKSRTPD--- ---KMKNLSKSWWKKYCCFV------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Pan_troglodytes_RHOU -------------------------------------------------------------------------------- ---------------------------------------------------------------------------V---- --VSVDGRPVRLQLCDTAG--------------------------QDEFDKLRPLCYTNTDIFLLCFSVVSPSSFQNVSE KWVPEI------------RCHCPKAPIILVGTQSDLREDVKVLIELDK---------------------CKEKPVPEEAA KLCAEEIKAASYIECSALTQKNLKEVFDAAIVAGIQYSDT-----------------QQQ-------PKKSKSRTPD--- ---KMKNLSKSWWKKYCCFV------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Mus_musculus_RHOU -----------------MAPQQ--GRPALPARCEPP-------------AAPPVPPRRERGGRGARGPGVSGGRGR---- ------------AGGAEGRGVKCVLVGDGAVGKTSLVVSYTTN-----------GYPTEYIPTAF--DNFS---AV---- --VSVDGRPVRLQLCDTAG--------------------------QDEFDKLRPLCYTNTDIFLLCFSVVSPTSFQNVGE KWVPEI------------RRHCPKAPIILVGTQSDLREDVKVLIELDK---------------------CKEKPVPEEAA KLCAEEVKAVSYIECSALTQKNLKEVFDAAIVAGIQHSDS-----------------QLQ-------PKKSKSRTPD--- ---KVRDLSKSWWRKYCCLA------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Danio_rerio_RHOU_a -----------------MPPQGGGGEYKPVPG----------------TVVPPVPPRRLRSRDLSSAVKSR--------- ------------FGTAAERRVKCVLVGDGAVGKTSLIVSYTTN-----------GYPTEYVPTAF--DNFA---AV---- --VAVDGKPVKLQLCDTAG--------------------------QDEFDKLRPLCYTNADVFLLCFSVVSPSSFQNVRE KWVPEI------------RRHCPRAPILLVGTQSDLREDVKVLIQLAQ---------------------YKERPVEPQDA SVCAEEVQAVSYMECSALTQKNLKEVFDTAIVASIQYSDS-----------------QQQ--------KRLKKRTPD--- ---KMRKLSESWWKKYCCLA------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Homo_sapiens_RHOQ -------------------------------------------------------------------------------- ----------MAHG-PGALMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVS------- --VTVGGKQYLLGLYDTAG--------------------------QEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKE EWVPEL------------KEYAPNVPFLLIGTQIDLRDDPKTLARLND---------------------MKEKPICVEQG QKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKK-------------------HTV------------------- -----KKRIGSRCINCCLIT------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Mus_musculus_RHOQ -------------------------------------------------------------------------------- ----------MAHG-PGALMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVS------- --VTVGGKQYLLGLYDTAG--------------------------QEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKE EWVPEL------------KEYAPNVPFLLIGTQIDLRDDPKTLARLND---------------------MKEKPVCVEQG QKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKK-------------------HTV------------------- -----KKRIGSRCINCCLIT------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Gallus_gallus_RHOQ -------------------------------------------------------------------------------- ---------------------------------------YAND-----------AFPEEYVPTVF--DHYAVS------- --VTVEGKQYLLGLYDTAG--------------------------QEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKE EWVPEL------------KEYAPNVPFLLVGTQIDLRDDPKTLARLND---------------------MKEKPLSVEQG QKLAKEIGAYCYVECSALTQKGLKTVFDEAIIAILTPKK-------------------HTV------------------- -----KKRIGSRCINCCLIT------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Danio_rerio_RHOQ -------------------------------------------------------------------------------- ----------MANG-TGSIMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVS------- --VTVGGKQYLLGLYDTAG--------------------------QEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVRE EWVPEL------------QEYAPNIPYLLIGTQIDLRDDPKTIAKLND---------------------VKEKPIVTEQG QKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILAPKK-------------------GAL------------------- -----KRRLGPRCINCCLIT------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Tetraodon_nigroviridis_RHOQ_a -------------------------------------------------------------------------------- -EDGAGQVGIMANG-TGTIMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVS------- --VNVGGKQYLLGLYDTAG--------------------------QEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVRE EWVPEL------------QEYAPSVPYLLIGTQIDLRDDPKTIAKLND---------------------MKEKPIVTEQG QKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILAPKKK-----------------KGAL------------------- -----KRRLGPRCINCCLIT------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Homo_sapiens_RHOG -------------------------------------------------------------------------------- -------------MQS----IKCVVVGDGAVGKTCLLICYTTN-----------AFPKEYIPTVF--DNYSAQ------- --SAVDGRTVNLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRH KWHPEV------------CHHCPDVPILLVGTKKDLRAQPDTLRRLKE---------------------QGQAPITPQQG QALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLN-PTP-----------------IKR-------------------- -------------GRSCILL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Pan_troglodytes_RHOG -------------------------------------------------------------------------------- -------------MQS----IKCVVVGDGAVGKTCLLICYTTN-----------AFPKEYIPTVF--DNYSAQ------- --SAVDGRTVNLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRH KWHPEV------------CHHCPDVPILLVGTKKDLRAQPDTLRRLKE---------------------QGQAPITPQQG QALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLN-PTP-----------------IKP-------------------- -------------ARSCILL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Mus_musculus_RHOG -------------------------------------------------------------------------------- -------------MQS----IKCVVVGDGAVGKTCLLICYTTN-----------AFPKEYIPTVF--DNYSAQ------- --SAVDGRTVNLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRH KWHPEV------------CHHCPDVPILLVGTKKDLRAQPDTLRRLKE---------------------QGQAPITPQQG QALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLN-PTP-----------------IKR-------------------- -------------GRSCILL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Gallus_gallus_RHOG -------------------------------------------------------------------------------- -----AAEADSAAMQS----IKCVVVGDGAVGKTCLLICYTTN-----------AFPKEYIPTVF--DNYSAQ------- --NTVDGRTINLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFIICFSIASPPSYENVKH KWYPEV------------CHHCPSVPVLLVGTKKDLRTNPDTMRRLKE---------------------QNQAPISTQQG LSLCRQIRAVKYLECSALQQEGIKEVFTEAVRAVLN-PAP-----------------AKA-------------------- -------------KRPCVLL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Danio_rerio_RHOG_a -------------------------------------------------------------------------------- -------------MQS----IKCVVVGDGAVGKTCLLISYTTG-----------AFPKEYIPTVF--DNYSSQ------- --VSVDNRTVSLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFIICFSISSPPSYENIKH KWHPEV------------THHCPSVPILLVGTKSDLRNDADVLKKLKE---------------------QNQAPITTQQG QALARQIHAVKYRECSALSQDGIKDVFADAVRAYLS-PQP-----------------VAN-------------------- -------------KKPCILL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Danio_rerio_RHOG_b -------------------------------------------------------------------------------- -------------MQT----IKCVVVGDGAVGKTCLLISYTTN-----------AFPDEYIPTVF--DNYSTQ------- --TCVDGRAVSLNLWDTAG--------------------------QEEYDRLRTLSYPQTHVFIICFSVASPSSHANVRH KWHPEV------------CHHCPGVPVLLVGTKRDLRGDKETLEKLKE---------------------QGMSPTTPQQG SALARSIGAVRYLECSALLQEGVREVFNEAVRAVLY-PNA-----------------KKH-------------------- -------------TKKCVLL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Takifugu_rubripes_RHOG_a -------------------------------------------------------------------------------- -------------MQT----IKCVVVGDGAVGKTCLLISYTTN-----------AFPEEYIPTVF--DNYSAQ------- --MSVDGRTVSLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFIICFSIGSPSSHANVRH KWHPEV------------SHHCPNVPILLVGTKKDLRGDTETVKKLKE---------------------QGLAPTTHQQG NALAKQIGAVKYMECSALLQDGVREVFAEAVRAVLY-PVA-----------------KKN-------------------- -------------PKKCVLL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Takifugu_rubripes_RHOG_b -------------------------------------------------------------------------------- -------------MQS----VKCVVVGDGAVGKTCLLISYTTG-----------AFPKEYIPTVF--DNYSSQ------- --VTVDSRIVSLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFIICFSISSPASYENVKH KWHPEVRVQWHNFDNHQVSHHCPDVAILLVGTKSDLRNDPDTQKKLKE---------------------QNQSPVTHQQG AALARQIQAVRYMECSALNQDGIKDVFAEAVRAFLN-PQP-----------------TVS-------------------- -------------KRHCILL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Tetraodon_nigroviridis_RHOG_a -------------------------------------------------------------------------------- -------------MQS----VKCVVVGDGAVGKTCLLISYTTG-----------AFPKEYIPTVF--DNYSSQ------- --VTIDNRIVSLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFIICFAISSPASYENVKH KWHPEV------------SHHCPDVPILLVGTKSDLRSDPDTQKKLKE---------------------QNQTPVTHQQG AALARQIQAVRYMECSALNQDGIKDVFSEAVRAFLN-PQP-----------------TVS-------------------- -------------KRHCVLL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Tetraodon_nigroviridis_RHOG_b -------------------------------------------------------------------------------- -------------MQT----IKCVVVGDGAVGKTCLLISYTTN-----------AFPEEYIPTVF--DNYSAQ------- --MSVDGRTVSLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFIICFSIGSPSSHANVRH KWHPEV------------SHHCPNVPILLVGTKKDLRGDTETVKKLKE---------------------QGLAPTTHQQG NALAKQIGAVKYMECSALLQDGVKEVFAEAVRAVLY-PVA-----------------KKN-------------------- -------------PKRCVLL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Branchiostoma_floridae_RHOG -------------------------------------------------------------------------------- -------------MQA----IKCVVVGDGAVGKTCLLISYTTN-----------AFPGEYIPTVF--DNYSAN------- --VMVDGKPINLGLWDTAG--------------------------QEDYDRLRPLSYPQTDVFLICFSLISPASFENVRA KWHPEV------------SHHCPNTPIILVGTKLDLRDDKETIDKLQE---------------------KRLAPITYPQG LQMMKDIGAVKYLECSALTQKGLKTVFDEAIRAVLCPTKV-----------------PKK-------------------- -------------KKECIII------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Anopheles_gambiae_RHOG -------------------------------------------------------------------------------- -------------MQA----IKCVVVGDGAVGKTCLLISYTTN-----------AFPGEYIPTVF--DNYSAN------- --VMVDGKPINLGLWDTAG--------------------------QEDYDRLRPLSYPQTDVFLICFSLVNPASFENVRA KWYPEV------------RHHCPNIPIILVGTKLDLRDDKNTVDKLRD---------------------KKLSPITYPQG LAMAKEIGAVKYLECSALTQKGLKTVFDEAIRAVLCPMIP-----------------PKK-------------------- -------------KPKCNIL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Homo_sapiens_RHOJ -------------------------------------------------------------------------------M NCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVT------- --VTVGGKQHLLGLYDTAG--------------------------QEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQE EWVPEL------------KDCMPHVPYVLIGTQIDLRDDPKTLARLLY---------------------MKEKPLTYEHG VKLAKAIGAQCYLECSALTQKGLKAVFDEAILTIFHPKK------------------KK--------------------- ------KRCS-EGHSCCSII------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Pan_troglodytes_RHOJ -------------------------------------------------------------------------------M NCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVT------- --VTVGGKQHLLGLYDTAG--------------------------QEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQE EWVPEL------------KDCMPHVPYVLIGTQIDLRDDPKTLARLLY---------------------MKEKPLTYEHG VKLAKAIGAQCYLECSALTQKGLKAVFDEAILTIFHPKK------------------KK--------------------- ------KRCS-EGHSCCSII------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Mus_musculus_RHOJ -------------------------------------------------------------------------------M SCRERTDSSCGCNGHEENRILKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVT------- --VTVGGKQHLLGLYDTAG--------------------------QEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQE EWVPEL------------KDCMPHVPYVLIGTQIDLRDDPKTLARLLY---------------------MKEKPLTYEHG VKLAKAIGAQCYLECSALTQKGLKAVFDEAILTIFHPKK------------------KK--------------------- ------KGCL-GCHGCCAII------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Gallus_gallus_RHOJ -------------------------------------------------------------------------------M SCKAEGDDCTDGSSNSTKKMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVT------- --VTVGGQQHLLGLYDTAG--------------------------QEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQE EWVPEL------------KVCMPNVPYVLIGTQIDLRDDPKTLARLLY---------------------MKEKPLTYEHG VKLAKEIGAQCYLECSALTQKGLKTVFDEAILTIFHPKK------------------KK--------------------- ------KHCA-KCHRCCTIV------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Danio_rerio_RHOJ -------------------------------------------------------------------MPTLSSKSRQNAL EAAEDGGSNSDPVNTTAKKMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYIPTVF--DHYAVN------- --VTVSGRQHLLGLYDTAG--------------------------QEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQE EWVPEL------------RSCMPHVPYILIGTQIDLRDDPKTLARLLQ---------------------MKEKPLTYEQG LKLAREIGAQCYLECSALTQKGLKTVFDEAILTIFSPKK------------------QK--------------------- ------RGCA-ACRCCCALV------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Homo_sapiens_RHOV -----------------------------------------------------MPPRELSE-AEPPPLRAPTP------- --------PPRRRSAPPELGIKCVLVGDGAVGKSSLIVSYTCN-----------GYPARYRPTAL--DTFS---VQ---- --VLVDGAPVRIELWDTAG--------------------------QEDFDRLRSLCYPDTDVFLACFSVVQPSSFQNITE KWLPEI------------RTHNPQAPVLLVGTQADLRDDVNVLIQLDQG--------------------GREGPVPQPQA QGLAEKIRACCYLECSALTQKNLKEVFDSAILSAIEHKAR-----------------LEKK-------LNAKG------- ----VRTLSRCRWKKFFCFV------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Pan_troglodytes_RHOV -----------------------------------------------------MPPRELSE-AEPPPLRAPTP------- --------PPRRRSAPPELGIKCVLVGDGAVGKSSLIVSYTCN-----------GYPARYRPTAL--DTFS---VQ---- --VLVDGAPVRIELWDTAG--------------------------QEDFDRLRSLCYPDTDVFLACFSVVQPSSFQNITE KWLPEI------------RTHNPQAPVLLVGTQADLRDDVNVLIQLDQG--------------------GREGPVPQPQA QGLAEKIRACCYLECSALTQKNLKEVFDSAILSAIEHKAR-----------------LEKK-------LNAKG------- ----VRTLSRCRWKKFFCFV------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Mus_musculus_RHOV -----------------------------------------------------MPPRELSE-AEPPPLPASTP------- --------PPRRRSAPPELGIKCVLVGDGAVGKSSLIVSYTCN-----------GYPARYRPTAL--DTFS---VQ---- --VLVDGAPVRIELWDTAG--------------------------QEDFDRLRSLCYPDTDVFLACFSVVQPSSFQNITE KWLPEI------------RTHNPQAPVLLVGTQADLRDDVNVLIQLDQG--------------------GREGPVPQPQA QGLAEKIRACCYLECSALTQKNLKEVFDSAILSAIEHKAR-----------------LEKK-------LNAKG------- ----VRTLSRCRWKKFFCFV------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Gallus_gallus_RHOV -----------------------------------------------------MPPQELLD--YAPALRRH--------- ---------SPPRGSGPELGIKCVLVGDGAVGKTSLVVSYTTN-----------GYPDEYQPTAL--DTFS---VQ---- --VLVDGAPVRIQLWDTAG--------------------------QEDFDCLRSLCYPDTDVFLVCFSVVNPSSFQNITE KWIPEI------------RTHNPRAPVLLVGTQADLRDDVNVLISLDR---------------------YHVKPVPRPQA EGLADKIRAEAYLECSALTQKNLKEVFDMAIVSGVEHKAR-----------------QEKK-------MTAKG------- ----IKTLSKCRWKKFFCFV------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Xenopus_tropicalis_RHOV -----------------------------------------------------MPPQVMLD--CSDQKRLSPQLSELLC- --------KQNSRPNSQELGIKCVLVGDGAVGKTSLVISYTIN-----------GYPTEYQPTAL--DTFS---VQ---- --VLVDGAPVRIQLCDTAG--------------------------QEDFDHLRSLCYAETDVFLVCFSVVNPSSFQNVTE KWIPEI------------RTHSPHTPIVLVGTQADLRDDVNVLINLSR---------------------SHVKPVSESQA QAVAQKIRAQTYIECSALTQKNLKEVFDASILSAIKHKAR-----------------LEKK-------LTSKG------- ----VKRLSKCRWKKYFCFV------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >Danio_rerio_RHOV -----------------------------------------------------MPP-QMDYFYHESRVPSVCL------- ---------EQDEELLEP-AISCMLVGDGAVGKTSMIVSYTTN-----------GYPTDYKQTAF--DVFS---GQ---- --VQVDGTPVRIQLMDTAG--------------------------QEEFDEFRSLSYAHTDVFLLCFSVVNPTSFQNITK