>Homo_sapiens_RBM46 -------------------------------------------------------------------------------- --------------------------------------------------MNEENIDGTNG------------------- -----------CSKVRTG-----------------------------IQNEAALLALMEKTGYNMVQENGQRKFGGPPPG W---EGPPPPRGC-----EVFVGKIPRDMY-EDELVPVFERAGKIYEFRLMMEFSG-ENRGYAFVMYTTKEEAQLAIRIL --------------------------------------NNYEIR-PGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMK KVT----EGVVDVIVYPSATDKTK-NRGFAFVEYESHRAAAMARRKLIP-GTFQLWGHT-IQVDWADPEKEVDEETMQRV -------------KVLYVRNLMISTT----------------------EETIKAEFNK-FKPG----------------- --------------------AVERVKKLRDYAFVHFFNREDAVA--AMSVMNG---KCIDGA-----SIEVTLAKPVNKE --------NTWR---QHLNGQ-----------------------------ISPN-----------SENLIVFANKEESHP KTLGKLPTL-----PARLNGQHSP--------SPPEVERCT--------------------------------------Y PFYPGTKLT------------------------PISMYSLKSN---HFNS-----AVMHLDYYCNKNNWAPPEYYLYSTT SQDGKVLLVYKIVIPAIANG---------------------SQSYFMPDKLC---TTLEDAKELAAQFTLLHLD------ --------------------------------------------YNFHRSSINSLSPVSATLSS---------------G TPSVLPYTSRPY---SYPGYPLSPT---ISLANGSHVGQRLCISNQASFF-------- >Mus_musculus_RBM46 -------------------------------------------------------------------------------- --------------------------------------------------MNEENTDGTNG------------------- -----------CSKVRTG-----------------------------TQNEAALLALMEKTGYNMVQENGQRKFGGPPPG W---EGPPPPRGC-----EVFVGKIPRDMY-EDELVPVFERAGKIYEFRLMMEFSG-ENRGYAFVMYTTKEEAQLAIRIL --------------------------------------NNYEIR-PGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMK KVT----EGVVDVIVYPSATDKTK-NRGFAFVEYESHRAAAMARRKLIP-GTFQLWGHT-IQVDWADPEKEVDEETMQRV -------------KVLYVRNLMISTT----------------------EETIKAEFSK-FKPG----------------- --------------------AVERVKKLRDYAFVHFFHREDAVA--AMSVMNG---KCIDGA-----SIEVTLAKPVNKE --------NTWR---QHLNGQ-----------------------------ISPN-----------SENLLVYANKEESHS KSLGKPPTL-----PTRLNGQHSP--------SPPEIERCT--------------------------------------Y PFFPGTKLT------------------------PISMYSLKSN---HFNS-----AVMHLDYYCNKNNWAPPEYYLYSTT SQDGKVLLVYKIVIPAIANG---------------------SQSYFMPDKLC---TTLEDAKELAAQFTLLHLD------ --------------------------------------------FNFRRSSINSLSPVSTTLSS---------------G TPSMLPYTSRPS---SYPSYPLSPT---ISLANGSHVGQRLYISNQASFF-------- >Canis_familiaris_RBM46 -------------------------------------------------------------------------------- --------------------------------------------------MNEENIDGTNG------------------- -----------CSKVRTG-----------------------------IQNEAALLALMEKTGYNMVQENGQRKFGGPPPG W---EGPPPPRGC-----EVFVGKIPRDMY-EDELVPVFERAGKIYEFRLMMEFSG-ENRGYAFVMYTTKEEAQLAIRIL --------------------------------------NNYEIR-PGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMK KVT----EGVVDVIVYPSATDKTK-NRGFAFVEYESHRAAAMARRKLIP-GTFQLWGHT-IQVDWADPEKEVDEETMQRV -------------KVLYVRNLMISTT----------------------EETIKAEFNK-FKPG----------------- --------------------AVERVKKLRDYAFVHFFNREDAVA--AMSVMNG---KCIDGA-----SIEVTLAKPVNKE --------NTWR---QHLNGQ-----------------------------ISPN-----------SENLIVFANKEESHP KTLGKPPTL-----PARLNGQHSP--------SPPEIERCT--------------------------------------Y PFFPGTKLT------------------------PISMYSLKSN---HFNS-----AVMHLDYYCNKNNWAPPEYYLYSTT SQDGKVLLVYKIVIPAIANG---------------------SQSYFMPDKLC---TTLEDAKELAAQFTLLHLD------ --------------------------------------------YTFRRSSINSLSPVSATLSS---------------G TPSVLPYTSRPY---SYPSYPLSPT---ISLTNGSHVGQRLYISNQASFF-------- >Bos_taurus_RBM46 -------------------------------------------------------------------------------- --------------------------------------------------MSEETIDGTNG------------------- -----------CSKVRTG-----------------------------TQNEAALLALMEKTGYNMVQENGQRKFGGPPPG W---EGPPPPRGC-----EVFVGKIPRDMY-EDELVPVFERAGKIYEFRLMMEFSG-ENRGYAFVMYTTKEEAQLAIRIL --------------------------------------NNYEIR-PGKFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMK KVT----EGVVDVIVYPSATDKTK-NRGFAFVEYESHRAAAMARRKLIP-GTFQLWGHT-IQVDWADPEKEVDEETMQRV -------------KVLYVRNLMISTT----------------------EETIKAEFNK-FKPG----------------- --------------------SVERVKKLRDYAFVHFFNREDAVA--AMSVMNG---KCIDGA-----SIEVTLAKPVNKE --------NTWR---QHLNGQ-----------------------------ISPN-----------SENLIVFANKEESHP KILGKPPAL-----PARLNGQHSP--------SPPEIERCT--------------------------------------Y PFFPGTKLT------------------------PISMYSLKSN---HFNS-----AVMHLDYYCNKNNWAPPEYYLYSTT SQDGKVLLVYKIIIPAIANG---------------------SQSYFMPDKLC---TTLEDAKELAAQFTLLHLD------ --------------------------------------------YNFRRSSINSLSPVSATLSS---------------G TPSVLPYTSRPY---SYSSYSLSPT---IPLANGSHVGQRLYISNQASFF-------- >Equus_caballus_RBM46 -------------------------------------------------------------------------------- --------------------------------------------------MNEESIDGTNG------------------- -----------CNKVRTG-----------------------------TQNEAALLALMEKTGYNMVQENGQRKFGGPPPG W---EGPPPPRGC-----EVFVGKIPRDMY-EDELVPVFERAGKIYEFRLMMEFSG-ENRGYAFVMYTTKEEAQLAIRIL --------------------------------------NNYEIR-PGRFIGVCVSLDNCRLFIGAIPKEKKKEEILDEMK KVT----EGVVDVIVYPSATDKTK-NRGFAFVEYESHRAAAMARRKLIP-GTFQLWGHT-IQVDWADPEKEVDEETMQRV -------------KVLYVRNLMISTT----------------------EETIKAEFNK-FKPG----------------- --------------------AVERVKKLRDYAFVHFFNREDAVA--AMSVMNG---KCIDGA-----SIEVTLAKPVNKE --------NTWR---QHLNGQ-----------------------------ISPN-----------SENLIVFANKEENHL KTVGKPPTL-----PARLNGQHSP--------SPPEIERCT--------------------------------------Y PFFPGTKLT------------------------PISMYSLKSN---HFSS-----AVMHLDYYCNKNNWPPPEYYLYS-T SQDGKVLLVYKIVIPAIANG---------------------SQSYFMPDKLC---TTLEDAKELAAQFTLLHLD------ --------------------------------------------YNFRRSSINSLSPVSATLSS---------------G TPSVLPYTSRPY---SYPSYSLSPA---ISLANGSHVGQRLYISNQASFF-------- >Gallus_gallus_RBM46 -------------------------------------------------------------------------------- --------------------------------------------------MNEENSAATSE------------------- -----------SDKMRGG-----------------------------NQKAAALLALLDKTGYNMIQENGQRKFGGPPPG W---EGPPPPRGC-----EVFVGKIPRNIY-EDELVPLFERAGKIYELRLMMEFS------------------------- ----------------------------------------------GRFIGVCISLDNCRLFIGAIPREKKKEEILKEMK RIT----EGVVDVIVCPDATDRTK-NRGFAFVEYESHRAAAMARRRLLP-GTFQLWGRA-VQVDWACPEKEVDAETMRRV -------------KVLYVRNLMISTT----------------------EDTIKAEFNK-FKPR----------------- --------------------VVERVKKLRDYAFVHFYNREDAVA--AMSIMNG---KCIDGA-----SIEVTLAKPVNKE --------STWK---QHLNGH-----------------------------VSPC-----------SENLMEFRSREDGHQ KSVGKPASL-----SLSLNGQHSP--------SSPELEWYP--------------------------------------Y PFLPGVKLI------------------------PISMYSLKSS---YFSS-----AVMRLDYFCYKNNWLPPEYYLYSTT SQDGKIHLVCKVLIPSIADG---------------------SQSCFMSHKLC---TTLEDARELAARMALLHLD------ -----------------------------------------------------SCTPNSA-------------------- ---------------------------------------------------------- >Xenopus_tropicalis_RBM46 -------------------------------------------------------------------------------- --------------------------------------------------MEDNCTDMFNG------------------- -----------CSKFDFS-----------------------------IQTQVALLALIDKTGYTMVQVNGQRKFGGPPPG W---EGPPPPRGC-----EVFVGKIPRDMY-EDELVPLFERAGKIYEFRLMMEFSG-ENRGYAFVMYTNKEEALLAIRML --------------------------------------NNYEIR-QGKFIGVCASLDNCRLFIGSIPQEKRKEDILEEMK KVT----EGVMDVIVCPSATDKTK-NRGFAFVTYESHRAAAMARRKLIP-GTFQLWGRT-IKVDWADPEKEVDEETMQKV -------------KVLYVRNLMMSTT----------------------EETIKAEFNR-YKPG----------------- --------------------VVERVKKIRDYAFVHFFRRDYAIA--AMSEMNG---RLIDGA-----RIEVTLAKPVNKE --------AAWR---QNGNGH-----------------------------MNPN-----------SECLLNFANKE-GSQ KVLDMCSNV-----PAYYN-QNSP--------TFLEAERCT--------------------------------------Y PCIPGTKLT------------------------PMNLYSLKIN---HFHS-----AVMHLEYYCYKNNWSFPEYYLYATT GQDGKMLLAYKVIVPAIAGN---------------------TNSYFMPDKLC---SIVEDAKELAAQFTLMHLD------ --------------------------------------------YSYHPTSGKNISLPSTAAAS---------------G SSGVLPYTPKPY---SYSSYPSSPN---VSLTNGGSVGKQLYVSNQASYFSG------ >Danio_rerio_RBM46_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------MD-----------------------------SSKEAALLALMDRTGYSMVQENGQRKFGGPPPG W---EGPPPPRGC-----EVFVGKIPRDMY-EDELVPVFEQAGHIYEFRLMMEFSG-ENRGYAFVMYTTREKAQRAIQLL --------------------------------------DNYEIR-PGKFIGVCVSLDNCRLFIGSIPKDKKKEEIQEEMM KVT----EGVMDVIVYPSAVDRMK-NRGFAFVEYESHKAAAMARRKLIP-GTFQLWGHT-IQVDWAEPEKELDEETMQRV -------------RVLYVRNLMLSTT----------------------EETLRSEFSQ-LKPG----------------- --------------------SVERVKKLTDYAFIHFYNREDALT--ALESMNG---KVIDGS-----PIEVTLAKPASK- ---DGNKRFGPR---NCHNGV-----------------------------TAAGGY---------GDSNFLFQTRNDMTI GAMGNGLNA-----HA---LSLPY---------AVDLDRCV--------------------------------------Y PFLPGSTLV------------------------PVSLNTVKPS---QLSS-----AVSLLDYYCHKNDWSLPEYHLYSLA GQEGKVMLIYKVVISSTR-------------------------RSFMPDKVC---TILEDAKELAAQNALWNLD------ -------------------------------------------CSSGS----------SLNVSP---------------P APSGSGFLSFGC---RSLPYPAYPM---ASISP----PLPISCSSAQRLFIPNQSSFL >Takifugu_rubripes_RBM46_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------VS-----------------------------CAEVVALLDLMEKTGYSMVQENGQRKYGGPPPG W---EGPPPPRGC-----EVFVGKIPRDMY-EDELVPLFERAGKLYEFRLMMEFTG-ENRGYAFVMYTNKEAAQRAIQML --------------------------------------DNYKVR-PGKFIGVCVSLDNCRLFIGSIPKEKTKDEVMAEMK KVT----DGVVDVIMYPSSTDKSR-NRGFAFVEYKSHKAAAMARRKLIP-GTFQLWGQS-IQVDWAEPEKDVEEEVMQRV -------------RVIYVRNLMLSTT----------------------EETLFQEFSH-FKPG----------------- --------------------SVERVKKLTDYAFVHYYCREDALA--ALAIMNG---VQIDGA-----TIEVMLAKPATIK EDSNGSRRHGNR---GYLGNS-----------------------------STAS-----------GGKVCMYRSNGGMMG GASNEDGHL-----RT---MTLPS----------CDKDGLL--------------------------------------F PLFPGTPLS------------------------PTSVLALKLS---QFTS-----AVSLLDVYCCKNNWSEPEYHLYSTP GLDRTLLVLFKVVISSIN-------------------------STYIPNKLC---VLLEDAKELAAWTALWNLG------ -------------------------------------------TTPSSPSSPLTVSPPATNPG----------------M LPCSSRAITPCL---SSSPHPPPPP---FHLSPLTHLP-TLSTPSYQ----------- >Tetraodon_nigroviridis_RBM46_a -------------------------------------------------------------------------------- ------------------------------------------------------------M------------------- -----------TDEVKAS-----------------------------CAEVVALLDLMEKTGYSMVQENGQRKYGGPPPD W---EGPPPPRGC-----EVFVGKIPRDMY-EDELVPLFERAGKLYEFRLMMEFTG-ENRGYAFVMYTNKEAAQRAIQML --------------------------------------DNYKVR-PGKFIGVCVSLDNCRLFLGSIPKEKTKDEVLAEMK KLT----DGVVDVIMYPSSTDKSK-NRGFAFVEYKSHKAAAMARRKLIP-GTFQLWGQS-IQVDWAQPEKDVEEEVMQRV -------------RVLYVRNLMLNTS----------------------EETLFKAFSH-FKPG----------------- --------------------SVERVKKFTDYAFVHYYCREDALA--ALDPMNG---VLIDGA-----AVEVMLAKPAISK EDSSGSRRHGSR---GYLKSN-----------------------------NTAG-----------GGK---YLTDQALDN KDLNEGGPT-----HTNYCLVLP-----------GDRDGHF--------------------------------------F PLFPGTPLS------------------------HTSVLALKPS---QFST-----AVSLLDVYCRQNNWLEPEYHLYSTP GLDTTLLLLYKVVISSIH-------------------------STYMPGKLC---VLLDEAKELAAWTALWNLG------ -------------------------------------------TNIQTLLCLLCILNTSLNPIS---------------Q KPLNSSFLSGAT---CESPSSPSSP---LALSPTATSPGMLTCSSKQRLYSPLNSETG >Oryzias_latipes_RBM46_a -------------------------------------------------------------------------------- ----------------------------------------------------SEDADLLSS------------------- -----------REDLKAS-----------------------------CAKEMALLALMEKTGYNMVQENGQRKYGGPPP- -----GETRPQGC-----EVFVGKVPRDMY-EDELVPLFESAGRIYEFRLMMEFSG-ENRGYAFVMYTSREEAVRAIQML --------------------------------------DGYEVR-PGRFIGVCVSLDNCRLFIGSIPRDRRKEEILEEMR KVT----DGVVDVIVYPSSSDRNR-NRGFAFVEYESHKTAAMARRKLIP-GTFQLWGHP-IQVDWAEPEKDMEEEAMQRV -------------RVLYVRNLMLDTT----------------------EETLRREFSR-FKPG----------------- --------------------SVERVKKLTDYAFVHFRSRSEALA--TLAVMNG---VQIDGT-----TVEVSLAKPTGNK EPVTFPLWRN-----EYIHPV-----------------------------SPKD-----------KRLDLLYCNIKESTP PSLMKFSIF-----VG---GALK------------EPERCR--------------------------------------L PLLPCTPLA------------------------PTSLLSLKPS---QINS-----AVTLLEYHCRRNCWPPPEYHLYSTP DQDGNLLLLYKVVMPSAQ-------------------------GTFIPDKLC---LLLEDAKEVAAHNALWNL------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Branchiostoma_floridae_RBM46 -------------------------------------------------------------------------------- --------------------------------------------------MSENDANPQ--------------------- -----------GPQGITG-----------------------------AQNEAALLSLMERTGYNIIQENGQRKYGGPPPG W---EGVTPSRGC-----EVFVGKIPRDLF-EDELVPVFESIGKIYELRLMMDFNG-NNRGYAFVMYTSRDDAKRAVKQL --------------------------------------NNYEIR-KGRLLGVCPSVDNCRLFVGGIPKNKKKHEILEEMS KVT----EGVVDVIVYPSATDKTK-NRGFAFVEYESHRAAAMARRKLIP-GRIQLWGHQ-IAVDWAEPEVEVDEDIMKSV -------------KVLYVRNLLLTTT----------------------EESLKESFENVVSPG----------------- --------------------SVERVKKIRDYAFVHFKTREEAVK--AMNATNG---QLIDGC-----QVEVTLAKPVDRD NYVRYTRGAGRGMPMEIYPTGYEN--------------------YYIPTPYPPT---------HLYPAAAAAAAAFAP-- ANLRFQ-GRSSLGARGVMR---VRG------RGAAGA-RGAGGSRGYFSYGLT---RGG---------FYGQKK--KELF DLLPGMELT------------------------PTNPVTMKPL-----KS-----APQMLEEMCQKNQWGSPVYSLHSTM GPGERQLFLYKVTVPALASQ-------------------YPSAQPFQPTKLA---PSVEEAKSVAAEFVLNQLGI----- --------------------------------------------PLDVSSE---VPLAAMAATA---------------- ---------------------------------------------------------- >Homo_sapiens_RBM47 -------------------------------------------------------------------------------- --------------------------------------------------MTAEDSTA--AMSSDS----A--------- -----AGSSAKVPEGVAG-----------------------------APNEAALLALMERTGYSMVQENGQRKYGGPPPG W---EGPHPQRGC-----EVFVGKIPRDVY-EDELVPVFEAVGRIYELRLMMDFDG-KNRGYAFVMYCHKHEAKRAVREL --------------------------------------NNYEIR-PGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIA KVT----EGVLDVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMETV -------------KILYVRNLMIETT----------------------EDTIKKSFGQ-FNPG----------------- --------------------CVERVKKIRDYAFVHFTSREDAVH--AMNNLN---GTELEGS-----CLEVTLAKPVDKE QYSRYQKAARGGG-AAEA---AQ----------------------QPSYVYSCD----------PYTLAYYGYPYNALIG PNRDYFVKAGSIRGRGRGAAGNRAPGPRGSYLGGYSAGRGIYS-----------------------RYHEGKGKQQEKGY ELVPNLEIPT------------------------VNPVAIKPG-TVAIPAIGAQYS-MFPAAPAPKMIEDGKIHTVEHMI SPIAVQPDPASAAAAAAAAAAAAAA---------------VIPTVSTPPPFQ--GRPITPVYTVAPN--VQRIP------ -----------------------------------------------TAG-IYGASYVPFAAP----------------- ATATIATLQKNA---AAAAAMYGGYAGYIPQ-AFPAAAIQVPIPDVYQTY-------- >Mus_musculus_RBM47 -------------------------------------------------------------------------------- --------------------------------------------------MTAEDSAT--AMNSDP----T--------- -----VGSSTKVPEGVAG-----------------------------APNEAALLALIERTGYTMVQENGQRKYGGPPPG W---EGPHPQRGC-----EVFVGKIPRDVY-EDELVPVFETVGRIYELRLMMDFDG-KNRGYAFVMYCHKHEAKRAVREL --------------------------------------NNYEIR-PGRLLGVCCSVDNCRLFIGGIPKMKKRGEILEEIA KVT----EGVLNVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMQTV -------------KILYVRNLMIETT----------------------EETIKKSFGQ-FNPG----------------- --------------------CVERVKKIRDYAFVHFTSREDAVH--AMNNLN---GTELEGS-----CLEVTLAKPVDKE QYSRYQKAAKGGG-GSAEA-VAQ----------------------QPSYVYSCD----------PYTLAYYGYPYNALIG PNRDYFVKTGSIRGRGRGAAGNRTPGPRGSYLGGYSAGRGIYS-----------------------RYHEGKGKQQEKGY ELVPNLEISP------------------------VNPVAIKPG-TVAIPAIGAQYS-MFQAAPAPKIIEDGKIHTMEHMI SPIAVQPDPATAAAAAAAAAAAA-----------------VIPAVSTPPPFQ--GRPITPVYTVAPN--VQRIP------ -----------------------------------------------TAG-IYGASYVPFAAP----------------- ATATIATLQKN-----AAAAVYGGYAGYIPQ-AFP-AALQVPIHDVYQTY-------- >Canis_familiaris_RBM47 -------------------------------------------------------------------------------- --------------------------------------------------MTAEDAAA--AMSSDSA---AG-------- -----GAASAKAPEGVAG-----------------------------APNEAALLALLARTGYRMVQENGQRKYGGPPPG W---EGPHPQRGC-----EVFVGKIPRDVY-EDELVPVFEAVGRIYELRLMMDFDG-KNRGYAFVTYCHKGEAKRAVREL --------------------------------------NNHEIR-PGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIA KVT----EGVLDVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMETV -------------KILYVRNLMIETT----------------------EDTIKKSFGQ-FNPG----------------- --------------------CVERVKKIRDYAFVHFASREDAVL--AMNSLN---GTELEGS-----CLEVTLAKPVDKE QYSRYQKAAKGGG--AAEA-AAP----------------------QPGYVYSCD----------PYTLAYYGYPYNALIG PNRDYFVKAGSIRGRGRGAAGSRAPGPRGSYLGGYSAGRGIYS-----------------------RYHEGKGKQQEKGY ELVPNLEISA------------------------VNPVAIKPG-TVAIPAIGAQYS-MFQAAPAPKMIEDGKIHTMEHMI SPIAVQPDPASAAAAAAAAAAA------------------VIPAVSTPPPFQ--GRPITSVYTVAPN--VQRIP------ -----------------------------------------------AAG-LYGAGYVPFAAP----------------- ATATLATLQKN----AAAAAVYGGYAGYIPQ-AFPAATIQVPIHDVYPTY-------- >Bos_taurus_RBM47 -------------------------------------------------------------------------------- --------------------------------------------------MTAEDSTA--AMSSDS----A--------- -----TGSSAKVPEGVAG-----------------------------APNEAALLALMERTGYSMVQENGQRKYGGPPPG W---EGPHPQRGC-----EVFVGKIPRDVY-EDELVPVFETVGRIYELRLMMDFDG-KNRGYAFVMYCHKNEAKRAVREL --------------------------------------NNYEIR-PGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIA KVT----EGVLDVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMETV -------------KILYVRNLMIETT----------------------EDTIKKSFGQ-FNPG----------------- --------------------CVERVKKIRDYAFVHFASREDAVH--AMNNLN---GTELEGS-----CLEVTLAKPVDKE QYSRYQKAAKGGG-AAEAA-VVQ----------------------QPSYVYSCD----------PYTLAYYGYPYNALIG PNRDYFVKAGSIRGRGRGAAGNRAPGPRGSYLGGYSAGRGIYS-----------------------RYHEGKGKQQEKGY ELVPNLEISA------------------------VNPVAIKPG-TVAIPAIGAQYS-MFQAAPAPKMIEDGKIHTMEHMI SPIAVQPDPASAAAAAAAAAA-------------------VIPAVSTPPPFQ--GRPITPVYTVAPN--VQRIP------ -----------------------------------------------TAG-IYGASYVPFAAP----------------- ATATIATLQKNA---AAAAAMYGGYAGYIPQ-AFPAAAIQVPIHDVYQTY-------- >Equus_caballus_RBM47 -------------------------------------------------------------------------------- --------------------------------------------------MTAEDSTA--AMSSDS----A--------- -----AASSAKCPR-RAG-----------------------------ALNEAAAG-LSEAPGYSMWQETGSANTAAPPPG W---GGTAPQRGC-----E-FVGKIPRDVY-EDE-VPVFEAG-RIYELRLMMDFDG-KNRGYAFVMYCHKNEAKRAVREL --------------------------------------NNYEIR-PGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIA KVT----EGVLDVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMETV -------------KILYVRNLMIETT----------------------EDTIKKSFGQ-FNPG----------------- --------------------CVERVKKIRDYAFVHFTSREDAVH--AMNNLN---GTELEGS-----CLEVTLAKPVDKE QYSRYQKAAKGGG-AAEAA-AVQ----------------------QPSYVYSCD----------PYTLAYYGYPYNALIG PNRDYFVKAGSIRGRGRGAAGNRAPGPRGSYLGGYSAGRGIYS-----------------------RYHEGKGKQQEKGY ELVPNLEISA------------------------VNPVAIKPG-TVAIPAIGAQYS-MFQAAPAPKMIEDGKIHTMEHMI SPIAVQPDPASAAVAAAAAAA-------------------VIPAVSTPPPFQ--GRPITPVYTVAPN--VQRIP------ -----------------------------------------------TAG-IYGASYVPFAAP----------------- ATATIATLQKNA---AAAAAVYGGYAGYIPQ-AFPAAAIQVPIHDVYQTY-------- >Gallus_gallus_RBM47 -------------------------------------------------------------------------------- --------------------------------------------------MTAEDSAA--RMSNDST---NV-------- -----STTKV--PEGVAG-----------------------------APNEAALLALMERTGYSMIQENGQRKYGGPPPG W---DGLHPPRGC-----EVFVGKIPRDVY-EDELVPVFESVGRIYEMRLMMDFDG-KNRGYAFVMYTQKHEAKRAVREL --------------------------------------NNYEIR-PGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIA KVT----EGVLDVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMETV -------------KILYVRNLMIETT----------------------EDTIKKVFGQ-FNPG----------------- --------------------CVERVKKIRDYAFVHFTTREDAIH--AMNNLN---GVELEGS-----CLEVTLAKPVDKE QYTRYQKAAKGGAAATPEV-T-Q----------------------QPNYVYSCD----------PYTLAYYGYPYNALIG PNRDYFVKAGSIRGRGRGAAGNRAPGPRGSYLGGYSAGRGIYS-----------------------RYHEGKGKQQEKGY ELVPNLELPA------------------------VNPVAIKPG-AVAIPAIGAQYS-MFPAAPPAKMMEDGKIHAVEHII NPIAVQQDPAS-AAAAAAAAAA-----------------AVIPAVSTPPPFQ--GRPITPVYTMAPN--VQRIP------ -----------------------------------------------AAG-IYGTSYVPFAAPA---------------A ATATIATLQKNAAAAAAAAAAYGGYAGYIPP-AFPAATIQVPIHDVYQTY-------- >Anolis_carolinensis_RBM47 -------------------------------------------------------------------------------- --------------------------------------------------MTAEDSTA--RMNNDSS---KM-------- -----QANKVHIPEELAN-----------------------------VPNGPALIQLMERTGYNLVQENGQRKYGGPPPG W---EGLHPPRGC-----EVFVGKIPRDVY-EDELVPVFETAGRIYEMRLMMDFDG-KNRGYAFVMYTQKYEAKRAVKEL --------------------------------------NNYEIR-PGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIS KVT----EGVLDVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMETV -------------KILYVRNLMIETT----------------------EDTIKKVFGQ-FNPG----------------- --------------------CVERVKKIRDYAFVHFTSREDAVQ--AMNNLN---NTELEGS-----CLEVTLAKPVDKE QYTRYQNSSQRG-TTTTEV-T-Q----------------------QPNYVYSCD----------PYTLAYYGYPYNALIG PNREYFVKAGSVRGRGRGAAGNRTPGPRGSYFGGYSAGRGIYS-----------------------RYHEGKGKQQEKGY ELVPNLDLSA------------------------VSPVAIKPG-TVAIPTIGTQYS-MFQAAPTAKMLEDGKIHAVEHII SPIAVQQDPASAAAAAAAAAAAG----------------AVMPAVSTPPPFQ--GRPITPVYTMAPN--MQRIP------ -----------------------------------------------AAG-IYGASYVPFAAPA---------------A ATATLATLQKN-AAAAAAAAAYGGYAGYIPQ-AFPAATIQVPIHDVYQTY-------- >Xenopus_tropicalis_RBM47 -------------------------------------------------------------------------------- --------------------------------------------------MTAEDSTA--MISNESS------------- -----NMSTSNIPEGVAG-----------------------------APNEAALINLMERTGYTMVQENGQRKYGGPPPG W---EGSPPPRGC-----EVFVGKIPRDVY-EDELVPVFESAGRIFEMRLMMDFDG-KNRGYAFVMFTKKHEAKQAVREL --------------------------------------NNYEIR-PGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIS KVT----EGVLDVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMETV -------------KILYVRNLMIETS----------------------EDTIKKIFGQ-FNPG----------------- --------------------CVERVKKIRDYAFVHFSSREDAVQ--SMRKLN---GTELEGS-----CIEVTLAKPVDKE QYTRYQKAAKGGAPATATATEVT----------------------QPNYIYSCD----------PYTLAYYGYPYNALIG PNRDYFVKAGSLRGRGRGAAGNRSPGPRGAYLGGYSAGRGIYS-----------------------RYHEGKGKPQEKGF ELVPNLELPA------------------------VNPVALKPG-TVAIPTIGTQYS-MFQAASAAKLLEEGKIHGMEHMI NPMAVQADPAAAAAAAAAAAA-------------------VIPSVSTPPPFQ--GRPITPVYTMAPN--VQRIP------ -----------------------------------------------AAG-IYGASYLPIAAP----------------- ATAALATLQKN------TAAVYGGYAGYIPQ-AFPAATIQVPLHDIYPTY-------- >Danio_rerio_RBM47_a -------------------------------------------------------------------------------- --------------------------------------------------MTAEDSASAVAMSNPSPSSSSK-------S SSGHPQH-HCTVPEGVAG-----------------------------APNEAALVSLMERSGYGMVQENGQRKYG-PPPG W---QGTSPPRGC-----EIFVGKIPRDVY-EDELVPVFESVGRIYEMRLMMDFDG-KNRGYAFVMYTQKHEAKRAVREL --------------------------------------NNFEIR-PGRLLGVCSSVDNCRLFIGGIPKTKKREEILEEVS KVT----EGVLDVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMETV -------------KILYVRNLMIETS----------------------EEILRQTFGQ-FNPG----------------- --------------------CVERVKKIRDYAFVHFASRDDAVV--AMDNLN---GTEIEGS-----RIEVTLAKPVDKE QYTRYQKASKGTAAATTVEST------------------------QQSYVYQCD----------PYTLAYYGYPYNTLIG PNRDYFIKAGTVRGRGRAGASSRGPGPRGSYLGGYSAGRGIYS-----------------------RYHEGKTKLPDKPY EIMSNLELAA------------------------VNPVGIKPG-TMALPALGAQYPTVFSAAPATKLMEEGKIHPVEHLI NPLALQH-DPTAASATAA----------------------VIPAVSTPPPFQ--GRPITPVYAMAHN--IQRIPA----- -----------------------------------------------AAASLYGAGYMPIAAH----------------A NTATLAALQKN---AAV-AAAYGGYAGY-MPQAFPAATFQMPIHDVYQTY-------- >Takifugu_rubripes_RBM47_a -------------------------------------------------------------------------------- --------------------------------------------------MTAEDPTPSSAMSHNTAPSKAS-------S ASHHSFHGQVSIPEGVAG-----------------------------TPNEAALVALMERTGYGMVQENGQRKYG-PPPG W---NGPSPPRGC-----EIFVGKIPRDVY-EDELVPVFESVGRIYEMRLMMDFDG-KNRGYAFVMYTEKHEAKRAVREL --------------------------------------NNYEVR-PGRLLGVCSSVDNCRLFIGGIPKTKKREEILEEVS KVT----EGVIDVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMETV -------------KILYVRNLMMETS----------------------EETIRKVFSQ-WNPG----------------- --------------------CVERVKKIRDYAFVHFNSRDDAVL--AMNHLN---GTEVEGS-----CIEVTLAKPVDKE QYSR-QKASKGAP-ATPEAT-------------------------QQNYVYQCD----------PYTLAYYGYPYSTLIG PNREYFIKEVLCRGRGRPIAGNRTPGPRGSYLGGYSAGRGIYS-----------------------RYHDGKTKQPEKPH ELMPSLELAAS-----------------------VNPVGIKPG-TMALPALGAQYP-VFSAPPAAKLMEEGKVHTVEHLI NPLAMQHPEHTNTPAAAT----------------------VLPAVSTPPPFQ--GRPITPVYAMAHN--VQRIPT----- -----------------------------------------------AGG-LYGAGYIPIANYA---------------A NSAALAALQKN---AAVAAAAYGGYSTYTVPQAFPTTAFQLPIHDVYQTY-------- >Tetraodon_nigroviridis_RBM47_a -------------------------------------------------------------------------------- --------------------------------------------------MTAEDPAPSSAMSNNAAPSKTS-------G ASHHSFHGQVSVTEGVAG-----------------------------APNEPALVALMERTGYNMVQENGQRKYG-PPPG W---NGPSPQRGC-----EIFVGKIPRDVY-EDELVPVFESVGRIYEMRLMMDFDG-KNRGYAFVMYTEKHEAKRAVREL --------------------------------------NNYEVR-PGRLLGVCSSVDNCRLFIGGIPKTKKREEILEEVS KVT----EGVIDVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMETV -------------KILYVRNLMMETS----------------------EETIRKVFSQ-WNPG----------------- --------------------CVERVKKIRDYAFVHFNSRDDAVL--AMNQLN---GTEVEGS-----CIEVTLAKPVDKE QYSR-QKASKGAA-ATPEAT-------------------------QQNYVYQCD----------PYTLAYYGYPYNTLIG PNREYFIKAGTVRGRGRAVAGNRTPGPRGSYLGGYSAGRGIYS-----------------------RYHEGKTKQPEKPH ELMPSLELAAS-----------------------VNPVSIKPG-TIALPALGGQYP-MFSAPPAAKLIEEGKVHAVEHLI NPLTMQHPEHTNTTAAAT----------------------VLPAVSTPPPFQ--GRPITPVYAMAHN--VQRIPT----- -----------------------------------------------AGG-LYGAGYVPIANYA---------------A NSAALAALQKN---AAVAAAAYGGYSAYTVPQAFPATAFQLPIHDVYQTY-------- >Gasterosteus_aculeatus_RBM47_a -------------------------------------------------------------------------------- --------------------------------------------------MTAEDPASSSTMSNNAAPTKPPQPA----G ASHPSLHGQINTPEGVAG-----------------------------SPIEPALVSLMERTGYSMVQENGQRKYG-PPPG W---NATSPPRGC-----EIFVGKIPRDVY-EDELVPVFESVGRIYEMRLMMDFDG-KNRGYAFVMYTEKHEAKRAVREL --------------------------------------NNYEVR-PGRLLGVCSSVDNCRLFIGGIPKTKKREEILDEVS KVT----EGVLDVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMETV -------------KILYVRNLMMETS----------------------EETIRQVFSQ-WNHG----------------- --------------------CVERVKKIRDYAFVHFTSREDAVM--AMDHLN---GTEVEGS-----CIEVTLAKPVDKE QHSR-QKASKGTP-ATPEPA-------------------------PQNYVYQCD----------PYTLAYYGYPYNTLIG PNRDYFVKAGTVRGRGRAAAGNRTPGPRGSYLGGYSAGRGIYS-----------------------RYHEGKAKQPEKPY ELMPTLELAAS-----------------------VNPVGIKHG-AMALQTLGGQYP-VFSAAPTAKLMEEGKVHTVEHLI NPLAMQHADHTAATAAAT----------------------VMPSVSTPPPFQ--GRPITPVYAMAHN--VQRIPT----- -----------------------------------------------AAG-LYAGGYVPITNYA---------------A NSAALAALQKN---AAVAAAAYGGYAGYAMPQAFPAAAFQLPIHDVYQTY-------- >Oryzias_latipes_RBM47_a -------------------------------------------------------------------------------- --------------------------------------------------MTAEDPAASSTMSNNAAHAKPS-------A ASHHSLHGHINIPEGVAG-----------------------------ASNEAALVTLMERTGYTMVQENGQRKYG-PPPG W---NGPSPPRGC-----EIFVGKIPRDVY-EDELVPVFESVGRIYEMRLMMDFDG-KNRGYAFVMYTEKHEAKRAVREL --------------------------------------NNYEVR-PGRLLGVCSSVDNCRLFIGGIPKTKKREEILEEVS KVT----EGVLDVIVYASAADKMK-NRGFAFVEYESHRAAAMARRKLMP-GRIQLWGHQ-IAVDWAEPEIDVDEDVMETV -------------KILYVRNLMMETN----------------------EETIRQIFSQ-WNPG----------------- --------------------CVERVKKIRDYAFVHFTSRDDAVL--AMDNLN---GTEIEGS-----CIEVTLAKPVDKE QYSR-QKASKGAIPATPEATQ------------------------QQNYVYQCD----------PYTLAYYGYPYSTLIG PNRDYFVKAGTVRGRGRAAAGNRTPGPRGSYLGGYSAGRGIYS-----------------------RYHEGKTKQPEKPY ELMNSLELPAS-----------------------VNPVGIKPG-TMALPALGAQYP-VFSPTPAPKLMEDGKVHTVEHLI NPLAIQHPEHT-TAAAAT----------------------VLPAVSTPPPFQNQGRPITPVYAMAHN--VQRIPT----- -----------------------------------------------AGG-LYGPGFVPITNYT---------------A NTAALAALQKN---AAMTAAAYGGYAGYAVPQAFPAAAFQLPLHDIYQTY-------- >Ciona_intestinalis_RBM47 -------------------------------------------------------------------------------- -------------------------------------------MVIDETSAVCNGPD----------------------- -----------NENGLSG-----------------------------VPNEAALVALMKRTGYSITQENGQRKYGGPPPG W---ENKPPPRGA-----EVFVGKIPRDVF-EDELVPVFETAGRIYEMRLMMDFDG-KNRGYAFVMFTAKSDAKGAVKKL --------------------------------------NNYEIR-KGRMLGVCYSVDNCRLFVGGIPKTKKKDDIFAEMT KVT----EGVTDVIVYPSASDKTK-NRGFAFVEYDSHRAAAMARRKLIP-GRIQLWGHP-IAVDWAEPEQDVDDEIMGQV -------------KVLYVRNLMLDTT----------------------EDTLQNVFSQ-FKPG----------------- --------------------SVERVKKIRDYAFVHFSTREACIE--AMEKING---THIDQA-----EVEVTLAKPVDKS DYNRMAKVGAKVLNGTETS------------------------TPTQSLVQAPT-V------VNQNGMLVYPAGVYGN-- DIAYYSLGQYNLATGARPIYPTRGGLRTDRGRGAAGT-RAPSGRNSYLGYSAGKATYGR-------YYSKNNQ--ERPVA ADTAGLELI------------------------TQVATIPQVVP-TMVKS-----SDIILEEICQRQMWGSPSYQLLTTT GGDGRQLFLYKVSIPALASI-------------------FPTQPYFQPNKLC---VTVEEAKSYAAEYVLSQLAL----- --------------------------------------------QADG-------------------------------- ------TPAVVP---MATVFQQPSAPAAPYP--------------------------- >Ciona_savignyi_RBM47 -------------------------------------------------------------------------------- -----------------------------------------------------NGTT----------------------- -----------VGNGLAG-----------------------------VPNEATLIALTTRTGYSITQENGQRKYGGPPPG W---ENKPPPRGA-----EVFVGKIPRDVF-EDELVPVFETAGRIYEMRLMMDFDG-KNRGYAFVMFTTKSEAKGAVKKL --------------------------------------NNYEIR-KGRMLGVCYSVDNCRLFVGGIPKTKKKDDIFAEMN KVT----EGVIDVIVYPSASDKTK-NRGFAFVEYDSHRAAAMARRKLIP-GRIQLWGHP-IAVDWAEPEQDVDDEIMGQV -------------KVLYVRNLMLDTT----------------------EDTLQNVFSQ-FKPG----------------- --------------------SVERVKKIRDYAFVHFSTREACME--AMAKING---TEIDYA-----EVEVTLAKPVDKN DYNRMAKVGAKVLNGSETTSSAAQSMV----------------SSLISFVSSPA-V------VNQNGVIVYPAGVYNN-- DIAYYSLGQYNLATGARPIYPTRG-------RGAGGA-RGASSRNSYLGYSAGKATYGR-------YYSKNNQ--ERP-- --AEGLELI------------------------TQQPTV--ING-QVIPA-----SDVVLEEICQRHMWGNPTYQLLTTA GPDSRQLFLYKVSIPALASI-------------------FPQQPYFQPNKLC---VTVEEAKSYAAEYVLSQLAL----- --------------------------------------------QPDG-------------------------------- ------SPAVVP---LATVLPQATAAAAPYPVS------------------------- >Strongylocentrotus_purpuratus_RBM47 -------------------------------------------------------------------------------- --------------------------------------------------MEGSPTKS---------------------- -----------DPEGISG-----------------------------ARNEAALLTLMERTGYHIVQENGQRKYGGPPPG W---EGAQPSRGC-----EVFVGKIPRDLF-EDELVPVFMKIGKIYELRLMMDFSG-SNRGYAFVMYTTREDGKKAVKQL --------------------------------------NNYEIR-KGRYLGVCPSVDNCRLFVGGIPKNKKQEEILAEMA KVT----EQVVDVIVYPSINDKAK-NRGFAFVEYENHRAAAMARRKLIP-GRIQLWGHQ-IMVDWAEPEQDVDEDVMRGV -------------KILYVRNLMLHTT----------------------EETIAKEFNA-FKEG----------------- --------------------SVERVKKLRDFAFIHFFTREDALN--AMNAMDD---PLLDGA-----KIEVVLAKPVDKG NYVRYTPGAGRG---YVQQGLYG---------------------YEQQQQQQSSPS------YYPG---YSNPTGMPP-- -MMGMGGRGGGMMQRSPIRGGTRGR------GGAGGM-RGAGGTRSYGMGRG---------------------------- ----------------------------------YNRYDRKPQ--------------EVLEELCNKNQWGPPSFTLLSHR TNSDVQLFIYKVTVPGLSAN-------------------YP--DGLTPQKLC---QTPDQAKNFAAECLLASLGV----- --------------------------------------------PVDGEL------------------------------ ---------------------------------------------------------- >Homo_sapiens_DND1 -------------------------------------------------------------------------------- --------------------------------------------------MQSKRD------------------------ --------CELWCERVNP------------------------------ENKAALEAWVRETGIRLVQVNGQRKYGGPPPG WV---GSPPPAGS-----EVFIGRLPQDVY-EHQLIPLFQRVGRLYEFRLMMTFSG-LNRGFAYARYSSRRGAQAAIATL --------------------------------------HNHPLR-PSCPLLVCRSTEKCELSVDGLPPNLTRSALLLALQ PLG----PGLQEARLLPSPGPAP---GQIALLKFSSHRAAAMAKKALVE-GQSHLCGEQ-VAVEWLKPDLKQRLRQQLVG P---------------FLRSPQP------------------------EGSQLALARDK---------------------- ------------------------LGFQGARATLQLLCQRMKLG--SPVFLTKCLGIGPAGWHR-FWYQVVIPGHPVPFS GLIWVVLTLDGR----------------------------------------------------DGHEVAKDAVSVRLLQ ALS-ESGANLLWSAGAEAG-TMVKQ------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Canis_familiaris_DND1 -------------------------------------------------------------------------------- --------------------------------------------------MQSKRE------------------------ --------CELWCERVNP------------------------------ENKAALEAWVRETGIRLVQVNGQRKYGGPPPG WV---GSPPPAGS-----EVFIGRLPQDVY-EHQLIPLFQRVGRLYEFRLMMTFSG-LNRGFAYARYSSRRGAQAAIATL --------------------------------------HNHPLR-PSCPLLVCRSTEKCELSVDGLPPGLSRRALLLALQ PLG----SGLQEALLMPSPGPAP---AQIALLKFSSHRAAAMAKKALVE-GQSRLCGEQ-VSVEWLKPDLKQRLRQQFMG P---------------SLQGLQP------------------------EGSRLAPSRDK---------------------- ------------------------LESQGARATLQLLCQQMKLG--SPVFLTKCLGTGPAGWHR-FWYQVVIPGHPVPFS GLIWVVLAPEGQ----------------------------------------------------EGHEVAKDAVSARLLE ALR-ESGAGLFRSAGAEAG-MVVKQ------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Bos_taurus_DND1 -------------------------------------------------------------------------------- --------------------------------------------------MQSKRE------------------------ --------CELWCERVNP------------------------------ENKAALEAWVRETGIRLVQVNGQRKYGGPPPG WV---GSPPPAGS-----EVFIGRLPQDVY-EHQLIPLFQRVGRLYEFRLMMTFSG-LNRGFAYARYSSRRGAQAAIATL --------------------------------------HNHLLR-PSCPLLVCRSTEKCELSVDGLPPGLSHRALLRALQ PLG----PGLQEALLLPSPGPTP---AQIALLKFSSHRAAAMAKKALVE-GQSHLCGEQ-VAVEWLKPDLKQRLRQQLMG T---------------SLQCLQP------------------------EGNRLALARDQG--------------------- ------------------------LEFQGSQVALQLLCQRMKLG--SPVFLTKCLGTSPAGWHR-FWYQVVIPGHPVPFS GLIWVVLTPDGQ----------------------------------------------------DGHEVAKDAVSARLLE AMS-ESRASLLWSTGAEAGGTMVQQ------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Equus_caballus_DND1 -------------------------------------------------------------------------------- --------------------------------------------------MQSKRE------------------------ --------CELWCERVNP------------------------------ENKAALEAWVRETGIRLVQVNGQRKYGGPPPG WV---GSPPPAGS-----EVFIGRLPQDVY-EHQLIPLFQRVGRLYEFRLMMTFSG-LNRGFAYARYSSRRGAQAAIATL --------------------------------------HNHPLR-PSCPLLVCRSTEKCELSVDGLPPALSRRALLLALQ PLG----PGLQEALLLPSPGPAS---AQIALLKFSSHRAAAMAKKALVE-GQSRLCGEQ-VAVEWLKPDLKQRLRQQFVG P---------------SLQCLQP------------------------ESSRLALARDR---------------------- ------------------------LESQGARAALQLLCQRMKLG--SPVFLTKCLGTGPAGWHR-FWYQVVIPGHPVPFS GLIWVVLAPDGQ----------------------------------------------------DGHEVAKDAVSTRLLE ALS-ESGASLLWSAGAEAG-TVVKQ------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Xenopus_tropicalis_DND1 -------------------------------------------------------------------------------- ---------------------------------------MATSAGSQADFLKGDYKRIENMELTDEQ------------- -------KSQMWINSINS------------------------------ENKTALLAWVKETGIDLVQINGQRKYGGPPPG WI---GNAPVSGS-----EVFIGKIPQDIY-EDKLIPLFQSIGKLYEFRLMMTFSG-LNRGFAYARYIGRRQAVSAIMTL --------------------------------------NGYEIT-KGCCIVVCRSTEKSELALDGLPSHLEQPALKNILE EVT----SGVSALSLYQSPSNES---QVLAIVKYDSHRAAAMAKKSLCE-GSQFLRGLP-LTVSWLKTDMRQKLRSSDKH Q---------------QPKVPSP------LP---------------HSGSPEVPKETRL--------------------- ----------------------------SAVACLNILCLKMKLG--YPVFLIKLFSVTSFGWLR-FWYQVVIPRYPTPFC GYSWIIGENLELN---------------------------------------------------EKYDNAREVVAVKILS ALG------HITDPSVEKATASNAM------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Danio_rerio_DND1_a -------------------------------------------------------------------------------- -------------------------------------------------MVGDMDA------------------------ -------QQQELQQILNP------------------------------QKLKSLQEWMQRNSITLTQVNGQRKYGGPPPG WQ---GPAPGSGC-----EVFISQIPNDVY-EDRLIPLFQSIGTIYEFRLMMNFSG-QTRGFAYAKYGDPLTASAAVTTL --------------------------------------HQYRLP-EGGCLTVRRSTEKRQLRLGDLPVSMNESKLLMVLQ MLS----DGVEDVLLKP-PGPKGK--EVVALVNYTSHYAASMAKKVLVE-AFRNRYGIS-ITVRWTS-FSKSKRVEDTPQ E---------------DSCVTPLVLKPLSKPSLLHYDVPAHQSLLPLFRAVGGPTTSEQ-RDEMIPQPTIMSRNELIPQS SIRQRDEMVPQLPIRPRDGMAPQSPISLDAVSHLQWMCEVNRLG--SPQYEVHFHHAAPDGFLY-FAFKVLIPGLPLPLY GFVQILPGTSAR----------------------------------------------------AMKSEVYRAAAEQVIQ TLCRVSNLRPF--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Takifugu_rubripes_DND1_a -------------------------------------------------------------------------------- -------------------------------------------------LPPDMHA------------------------ -------TEFSVVDILNL------------------------------DRVKAFHEWLERTNTKITQVNGQRKYGGPPDK WD---GPVPGARC-----EIYITHIPRDTY-EDVLIPLFTTVGPLWQFRLMMNFSG-QNRGFAYAKYGSPAIAASAIQLL --------------------------------------HGHMIE-PGVSLCVRHSTEKRQLCIGGLPVSTKQADISQVMH TMC----EGIERVSLKSEPGIAG----MSAVVTFSSHYTASMAKKVVIE-AFKNQYALR-VSVSWFSSFKASPNRLLPPQ N---------------LVNVSCRSSVLLPRQ------TGTLFHSPSFCKAVGGPITPR----PYECSTPS---------- ----------------------SRASLPSPMMLLNNLCQTAGFG--PPHYKISCSRAGPDGYLH-FSYQVFILGINMSLE GVIMILPGANIS----------------------------------------------------STMEEAREAVAQQVLS ICCLFCSMHAC--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Tetraodon_nigroviridis_DND1_a -------------------------------------------------------------------------------- -----------------------------------------------------MAG------------------------ -------NHN---QMLNP------------------------------GEARKFEKWLKRTNTKLTQVNGQRKYGGPPEG WD---GPTPGARC-----EVFITNIPRNTY-EDVLIPLFGTVGSLWEFRLMMNFSG-QNRGFAYAKYGSQVIAASAVQLL --------------------------------------HGHVIK-PGVSLCVRPSTEKRQLSIGGLPVTTKHADLLQVLR AMC----EGVETVSVKAEPGIAG----VSAIVTFSSHHAATNAKKLVME-EFKKQYAIK-VTINWLPAVNPTSHDVLPPQ T---------------LVNVFCGSSELS--------------NSPGFCKAVGGP-TAA----QHGCSTTS---------- ----------------------SLMSATSPTMLLDYLCRKNGFG--RPHCEISCHHAEPDGYLH-FSYKVFNRGMN-TLE GVIMILPGVTAA----------------------------------------------------STMEEARRAVAQQVL- -CKLFPNEVSY--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Gasterosteus_aculeatus_DND1_a -------------------------------------------------------------------------------- --------------------------------------------------LPTK-------------------------- --------PPPPQKVLNH------------------------------ERVQALETWLRTTNAKLTQVNGQRKYGGPPQV WD---GPAPGAHC-----EVFISQIPRDTY-EDLLIPLFSSVGPLWEFRLMMNFSG-QNRGFAYCKYGSPDVANEAIRLL --------------------------------------HGYTIE-PTFRLNVRRSTEKRHLCIGDLPATTKQEALLKVLH VLA----DGVERVSLKAGPGIDG----VSAMVAFSSHHAASMAKKMLVE-AFKKQFSLK-VSITWQSTHKRPPSLLPPPQ K---------------PPRLTPSALPPR-------M-ARPPSFPQGFCRAVGGPAVP-----QHSARPSS---------- ------------SPSPSQGR--PVSPPPSPVTFLHELCKATAVG--QPLYKTYFSHAGPDGFLF-FNYKVHFTGAPATFE GLVMILPGPSAT----------------------------------------------------STLEEAQRAAAQQVLQ --RLSNNQLA---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Oryzias_latipes_DND1_a -------------------------------------------------------------------------------- -------------------------------------------------FLRDHNL------------------------ -------LPPPLPQVVNL------------------------------ERVQALQAWVKSTNTKLTQVNGQRKYGGPPDV WD---GPPPGARC-----EVFISQIPRDVY-EDLLIPLFSSVGALWEFRLMMNFSG-QNRGFAYAKYGTAAIANDAIHLL --------------------------------------HGYPLG-PGARLSVRCSIEKRQLCIQNLPASTRQEELLQVLR LLS----AGVESVALKAGPGIEG----VSAVVAFSSHHAASMAKKALGE-GRKQLMGLQ-GAGPKTTRFKKK-SVQDSPK V---------------PNRVRKPLLKPMHKKARLEF-ARAHAEKENLFVNYGGKPVTSSGRWQTACVTSCGQDGRLFPRS KVKETTLMVVEXSLHPTDGLRGQVMFSVSPVLLLRKLSEASGWG--DPHYEMLFSHAGPDGFLY-FTYKVHVPGAPTTFR GFVMILPGHCTS----------------------------------------------------TMLEEARRAAAQQVLQ --KLC--------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Homo_sapiens_A1CF -------------------------------------------------------------------------------- --------------------------------------------------MESNHK------------------------ -----------SGDGLSG-----------------------------TQKEAALRALVQRTGYSLVQENGQRKYGGPPPG W---DAAPPERGC-----EIFIGKLPRDLF-EDELIPLCEKIGKIYEMRMMMDFNG-NNRGYAFVTFSNKVEAKNAIKQL --------------------------------------NNYEIR-NGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMK KVT----EGVVDVIVYPSAADKTK-NRGFAFVEYESHRAAAMARRKLLP-GRIQLWGHG-IAVDWAEPEVEVDEDTMSSV -------------KILYVRNLMLSTS----------------------EEMIEKEFNN-IKPG----------------- --------------------AVERVKKIRDYAFVHFSNREDAVE--AMKALNG---KVLDGS-----PIEVTLAKPVDKD SYVRYTRGTGGR--GTMLQGEYT---------------------YSLGQVYDPT-T------TYLGAPVFYAPQTYAA-I PSLHFPATKGHLSNRAIIRAPSVREIYMNVPVGAAGV-RGLGG-RGYLAYTG----LGR------GYQVKGDKR-EDKLY DILPGMELT------------------------PMNPVTLKPQ---GIKL-----APQILEEICQKNNWGQPVYQLHSAI GQDQRQLFLYKITIPALASQ-------------------NPAIHPFTPPKLS---AFVDEAKTYAAEYTLQTLGI----- --------------------------------------------PTDGGD--GTMATAAAAATAFPG--------YAVPN AT-APVSAAQLK---QAVTLGQDLAAYTTYEVYPTFA-VTAR-GDGYGTF-------- >Mus_musculus_A1CF -------------------------------------------------------------------------------- --------------------------------------------------MESNHK------------------------ -----------SGDGLSG-----------------------------TQKEAALRALVQRTGYSLVQENGQRKYGGPPPG W---DSTPPERGC-----EIFIGKLPRDLF-EDELIPLCEKIGKIYEMRLMMDFNG-NNRGYAFVTFSNKQEAKNAIKQL --------------------------------------NNYEIR-TGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMK KVT----EGVVDVIVYPSAADKTK-NRGFAFVEYESHRAAAMARRRLLP-GRIQLWGHP-IAVDWAEPEVEVDEDTMSSV -------------KILYVRNLMLSTS----------------------EEMIEKEFNS-IKPG----------------- --------------------AVERVKKIRDYAFVHFSNREDAVE--AMKALNG---KVLDGS-----PIEVTLAKPVDKD SYVRYTRGTGGR--NTMLQGEYT---------------------YPLSHVYDPT-T------TYLGAPVFYTPQAYAA-I PSLHFPATKGHLSNRALIRTPSVREIYMNVPVGAAGV-RGLGG-RGYLAYTG----LGR------GYHVKGDKR-EDKLY DLLPGMELT------------------------PMNTVSLKPQ---GIKL-----APQILEEICQKNNWGQPVYQLHSAI GQDQRQLFLYKVTIPALASQ-------------------NPAIHPFIPPKLS---AYVDEAKRYAAEHTLQTLGI----- --------------------------------------------PTEGGDA-GTTAPTATSATVFPG--------YAVPS AT-APVSTAQLK---QAVTLGQDLAAYTTYEVYPTFA-LTTR-GDAYGTF-------- >Canis_familiaris_A1CF -------------------------------------------------------------------------------- --------------------------------------------------MESNHK------------------------ -----------SGDGLSG-----------------------------TQKEAALRALVQRTGYSLVQENGQRKYGGPPPG W---DAAPPERGC-----EIFIGKLPRDLF-EDELIPLCEKIGKIYEMRMMMDFNG-NNRGYAFVTFSNRQEAKDAIKQL --------------------------------------NNYEIR-NGRLLGVCASVDNCRLFVGGIPKTKKREEILAEMK KVT----EGVVDVIVYPSAADKTR-NRGFAFVEYESHRTAAMARRKLLP-GRIQLWGHP-IAVDWAEPEVEVDEDTMSSV -------------KILYVRNLMLSTS----------------------EEMIEKEFNN-IKPG----------------- --------------------AVERVKKIRDYAFVHFSNREDAVE--AMKALNG---KMLDGS-----PIEVTLAKPVDKD SYVRYTRGTGGR--GSMLQGEYT---------------------YSLGHVYDPT-T------TYLGAPVFYAPQAYTA-I PSLHFPATKGHLGNRAIIRAPSVREIYMNVPVGAAGV-RGLAG-RGYLAYTG----LGR------GYQVKGDKR-EDKLY DLLPGMELT------------------------PMNPVTLKPQ---GIKL-----APQILEEICQKNNWGQPVYQLHSAI GQDQRQLFLYKITIPALANQ-------------------NPTIHPFTPPKLS---AYVDEAKTYAAEYTLQTLGI----- --------------------------------------------PTDGAD----APTA-AAATAFPG--------YAVPN AT-APVSAAQLK---QAVTLGQDLA-YTTYEVYPTFA-VTAR-GDGYGAF-------- >Bos_taurus_A1CF -------------------------------------------------------------------------------- --------------------------------------------------MESNHK------------------------ -----------SGDGLSG-----------------------------TQKEAALRALVQRTGYSLVQENGQRKYGGPPPG W---DAAPPERGC-----EIFIGKLPRDLF-EDELIPLCEKIGKIYEMRMMMDFNG-NNRGYAFVTFSNKQEAKNAIKQL --------------------------------------NNYEIR-NGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMK KVT----EGVVDVIVYPSAADKTK-NRGFAFVEYENHRAAAMARRKLLP-GRIQLWGHP-IAVDWAEPEVEVDEDTMSSV -------------KILYVRNLMLSTS----------------------EEMIEKEFNN-IKPG----------------- --------------------AVERVKKIRDYAFVHFTNREDAVE--AMKALNG---KVLDGS-----PIEVTLAKPVDKD SYVRYTRGTGGR--GAMLQGEYT---------------------YSLGHVYDPT-T------TYLGAPVFYAPQAYTA-I PSLHFPTTKGHLGNRAIIRAPSVREIYMNVPVGAAGV-RGLGG-RGYLAYTG----LGR------GYQVKGDKR-EDKLY DLLPGMELT------------------------PMNPVTLKPQ---GIKL-----APQILEEICQKNNWGQPVYQLHSAI GQDQRQLFLYKITIPALASQ-------------------NPAIHPFTPPKLS---AYVDEAKTYAAEYTLQALGI----- --------------------------------------------PTDGADA-QTAAAAAASATAFPG--------YAVPS PT-ASVSAAQLK---QAVTLGQDLAAYAAYEVYPTFA-VTAR-GDGYGTF-------- >Equus_caballus_A1CF -------------------------------------------------------------------------------- --------------------------------------------------MESNHK------------------------ -----------SGDGLSG-----------------------------TQKEAALRALVQRTGYSLVQENGQRKYGGPPPG W---DAAPPERGC-----EIFIGKLPRDLF-EDELIPLCEKIGKIYEMRMMMDFNG-NNRGYAFVTFSNKQEAKNAIKQL --------------------------------------NNYEIR-NGRLLGVCASVDNCRLFVGGIPKTKKREEILLEMK KVT----EGVVDVIVYPSAADKTK-NRGFAFVEYESHRAAAMARRKLLP-GRIQLWGHP-IAVDWAEPEVEVDEDTMSSV -------------KILYVRNLMLSTS----------------------EEMIEKEFNN-IKPG----------------- --------------------AVERVKKIRDYAFVHFSNREDAVE--AMKALHG---KVLDGS-----PIEVTLAKPVDKD SYVRYTRGTGGR--GTMLQGEYT---------------------YSLGHVYDPT-T------TYLGAPVFYTPQAYTA-I PSLHFPATKGHLGNRAIIRAPSVR--------GAAGV-RGLGG-RGYLAYTG----LGR------GYQVKGDKR-EDKLY DLLPGMELT------------------------PMNPVTLKPQ---GIKL-----APQILEEICQKNNWGQPVYQLHSAI GQDQRQLFLYKISIPALASQ-------------------NPAIHPFTPPKLS---AYVDEAKTYAAEYTLQTLGI----- --------------------------------------------PTDGADA----PTTAAAAAAASV--------QDMP- ------SLMQLH---LCLQPSSSKQ--------------------------------- >Gallus_gallus_A1CF -------------------------------------------------------------------------------- --------------------------------------------------MESNHK------------------------ -----------SGDGLTG-----------------------------TQKEAALRALIQRTGYNLIQENGQRKYGGPPPG W---DGPPPERGC-----EIFIGKLPRDLF-EDELIPLCEKIGKIYEMRMMMDFNG-NNRGYAFVTFSNKQEARNAIKQL --------------------------------------NNYEIR-NGRLLGVCASVDNCRLFVGGIPKTKKREEILAEMK KVT----DGVVDVIVYPSAADKTK-NRGFAFVEYESHRAAAMARRKLLP-GRIQLWGHP-IAVDWAEPEVEVDEDTMSSV -------------KILYVRNLMLSTT----------------------EETIEKEFNN-IKQG----------------- --------------------AVERVKKIRDYAFVHFNKREDAVH--AMKALNG---KVLDGS-----PIEVTLAKPVDKD SYVRYTRGTGGR--GAVLQGEYT---------------------YAFGHVYDPA-A------TYLGAPVFYAPQAYAA-I PNFHFPATKG-LGSRSIIRPPSIR--------GAAGV-RGLGG-RGYLVYTG----LGR------GYQLKGEKRGEDKLY DLLPGMELT------------------------PMNHVTLKPQ---GVKL-----APQILEEICQKNNWGQPVYQLHSAI GQDQRQLFLYKITIPALASQ-------------------NPTIHPFTPPKLS---AYIDEAKTYAAEYTLQTLGI----- --------------------------------------------PTEGAEV-------PPAAPAFP--------GYTIAN AA-TTVTATQLK---QAVTMGQDLATYAAYEAYPAFA-VAAR-SDGYGAF-------- >Anolis_carolinensis_A1CF -------------------------------------------------------------------------------- --------------------------------------------------MESNQK------------------------ -----------SGDGLAG-----------------------------TQKEAALHTISQRTGYKLYQENGQRKYGGPPPG W---DGPPPERGC-----EIFIGKLPRDLF-EDELIPLCEKIGKIYEMRMMMDFNG-NNRGYAFVTFSNKQEARNAIRQL --------------------------------------NNYEIR-NGRLLGVCASVDNCRLFVGGIPKTKKREEILAEIK KVT----DGVVDVIVYPSAADKAK-NRGFAFVEYGSHRAAAMARRKLLP-GRIQLWGHP-IAVDWAEPEVEVDEDTMSAV -------------KILYVRNLMLSTT----------------------EETIEKEFSS-IKPG----------------- --------------------SVERVKKIRDYAFVHFNNREDAVE--AMKVLNG---KMVDGS-----PIKVTLAKPVDKD SYVRYTRGTGGR--GGAVLPEYT---------------------YTFGPVYDPA-A------AYLGTPVFYAPQAYAA-I PNLHFPAAKGHLANRATIRPPSIR--------GAAGV-RGLGG-RGYLANPA----LGR------GYQLKGEKREEEKLY DLLPGMELT------------------------PMNPISLKPQ---GIKL-----APQILEEICQKNNWGQPVYQLHSAV GQDQRQLFLYKITIPALASQ-------------------NPTMHPFTPPKLS---PYVDEAKTYAAEYTLQTLGI----- --------------------------------------------PTESTET-------PTATASFPG---------YIAS TA-ATVAATQLK---QAVTLGQDLAAYAAYEAYPAFA-VATR-SDGYGAF-------- >Xenopus_tropicalis_A1CF -------------------------------------------------------------------------------- --------------------------------------------------MESNQK------------------------ -----------SGEGMAG-----------------------------TQKEAALRALIQRTGYSLTQENGQRRYGGPPPG W---DGPPPERGC-----EIFIGKLPRDLF-EDELIPLCEKTGKVYEMRMMMDFNG-NNRGYAFVTFTNRQDARDAIKQL --------------------------------------NNYEIR-NGRLLGVCASVDNCRLFVGGIPKTKRREEILVEMR KVT----DGVLDVIVYPSAADKSK-NRGFAFVEYESHRAAAMARRKLLP-GRIQLWGHP-IAVDWAEPEVEVDEDTMSSV -------------KILYVRNLMLTTA----------------------EETIEKEFSN-VKPD----------------- --------------------ARRLKATHMPCTRCHFQRPVTVTR--ELCCIGA---KIIDGS-----PIEVTLAKPVDKE SYVRYTRGTGGR--GAAIQGEYA---------------------YTIGHVYDPT-T------AYLGAPVFYAPPAYTAAI PSIQFPPAKGYVSNRSLVRPPSVREIYMSVPVGAAGV-RGLGG-RGYLAYTG----LGRG---YAGFQMKGDKRADDKLY DILPGMELT------------------------PMTTVALKPQ---GIKL-----GPQILEEICQKNNWGQPVYQLHSAI GPDQRQLFLYKVTIPALASQ-------------------NPTIHPFTPPKLC---ISVDEAKTYAADYTLQTLGI----- --------------------------------------------PTETAEH----------PTAFAG--------YTIAN TP-AAVAATQLK---QAVALGQDIAAYATYEAYPAFA-VAAR-GDGYGAF-------- >Danio_rerio_A1CF_b -------------------------------------------------------------------------------- --------------------------------------------------METNQK------------------------ -----------CGDGLTG-----------------------------TQKEAALRALIQRTGYHIHQENGQRRYGGPPPG W---EGSPPERGS-----EIFVGKLPRDLF-EDELVPLCEKFGKIYEVRMMMDFNG-NNRGYAFVTFSTKQEAKNAMKQL --------------------------------------NNYEIR-NGRLLGVCASVDNCRLFVGGIPKTKKREEILAEMK KVT----DGVLDVIVYPSAADKAK-NRGFAFVEYETHRAAAMARRKLLP-GRIQLWGHP-IAVDWAEPEVEVDEDTMATV -------------KILYVRNLMLPTT----------------------EETIEKEFNS-IKPG----------------- --------------------AVERVKKIRDYAFVHFSQREDAIN--AMNALNG---KVIDGS-----PIEVTLAKPVDKD SYVRYTRGTGGRG-GTVLQGDYA---------------------YTVGQMYDPS-A------AYLGAPIFYAPHAYATIP NQFRFPSTKGQMSTRGLVRTPSVR------AVGAAGV-RGLGG-RGYLAYAG----VGR---GCGTYQLKTDKRPDDKLY DLLPGMELT------------------------PMNPVTLKPQ---GIKH-----APQILEDICQKNNWGQPVYQLHSAI GPDQRQLFLYKVTIPALATQ-------------------YPNIHPFTPAKLC---ASMDEAKLHAAEHTLQILGV----- --------------------------------------------QTEGADAS----AAAAVAAAFPG--------YAIAS TT-----GTQLK---QAVSLGQDLTAYATYEGYPAFA-VAAR-GDGYGVF-------- >Takifugu_rubripes_A1CF_a -------------------------------------------------------------------------------- --------------------------------------------------MEANQNA----------------------- -----------SGDELTG-----------------------------TQKEVQLRALTQRTGYQLRQENGQRRYGGPPPD W---NGPPPERGS-----EIFVGKLPRDLF-EDELVPLCEKFGKIYEVRMMMDFSG-NNRGYAFVTFSNKQEAKAAMKQL --------------------------------------NNYEIR-NGRLLGVCASVDNCRLFVGGIPKTKKREEIMCEMR KVT----DGVLDVIVYPSAADKSK-NRGFAFVEYESHRAAAMARRKLLP-GRIQLWGHA-IAVDWAEPEVEVDEDTMATV -------------KILYVRNLMLQTT----------------------EETIEKEFNS-LKQG----------------- --------------------AVERVKKIRDYAFVHFTQREDAIH--AMNALNG---KVVDGS-----PIEVTLAKPVDKD SYVRYTRGTGGRG-GS-LQTDYAT--------------------YSVGQMYDPS-T------AYLGAPMFYAPQTYAAMP GQFRFPLAKAHIGGRGLIRPPSVREIYMTVPVGAAGV-RGLGG-RGYLAYTTGLGAVGRCGSSGASY-LKVDKQAEEKLY ELLPGMELT------------------------PMSTAAMNLKAAAAIKP-----APQVLEELCQKNNWGQPVYQLHSAI GPDQRQLFLYKITIPALATQ-------------------YPNVHPFTPTKLC---AVVEEAKVHAAEHTLQTLGL----- --------------------------------------------LTEGASDAGCATTSAVASVAFPG--------YALVS PA-SSAVASQLK---QAVSLGQDMTAYATYDGYPAFA-VAARHGDRYGVY-------- >Tetraodon_nigroviridis_A1CF -------------------------------------------------------------------------------- --------------------------------------------------MESNQNA----------------------- -----------SGDELTG-----------------------------TQKEAQLRALTQRTGYQLRQENGQRRYGGPPPD W---NGPPPERGS-----EIFVGKLPRDLF-EDELVPLCEKFGQIYEVRMMMDFSG-NNRGYAFVTFSNKQEAKAAMKQL --------------------------------------NNYEIR-TGRLLGVCASVDNCRLFVGGIPKTKKREEIMCEMR KVT----EGVVDVIVYPSAADKSK-NRGFAFVEYESHRAAAMARRKLLP-GRIQLWGHA-IAVDWAEPEVEVDEDTMATV -------------KILYVRNLMLQTT----------------------EETIEKEFNS-LKEGTG--------------- --------------------AVERVKKIRDYAFVHFAQREDAIH--AMKELNG---KVVDGS-----PIEVTLAKPVDKD SYVRYTRGTGGRG-GS-LQTDYAT--------------------YSVGQVYDPS-A------AYLGAPMFYAPQTYATMP GQFRFPLAKTHIGGRGLIRPPSVREIYMTVPVGAAGV-RGLGG-RGYLAYASGVGALGRGGSSGASYNMKVDKQGEEKLY ELLPGMELT------------------------PMSTAAMNLK-AAAIKP-----APQVLEELCQKNNWGQPVYQLHSAI GPDQRQLFLYKITIPALATQ-------------------YPNVHPFTPTKLC---AAVEEAKVHAAEHTLQTLGL----- --------------------------------------------LTEGAGDAGCATAPAVAPVAFPG--------YTLVS PA-SSAMASQLK---QAMTLGQDLTAYATYDGYPAFA-VAARHSDRYGVY-------- >Gasterosteus_aculeatus_A1CF_a -------------------------------------------------------------------------------- --------------------------------------------------MEPNQKA----------------------- -----------GGDGLAG-----------------------------MQKEAALRALMQRTGYQLQQENGQRRS------ ---------ERGS-----EIFVGKLPRDLF-EDELVPLCEKYGTIYEVRMMMDFSG-NNRGYAFVTFGTKQEAKAAMKQL --------------------------------------NNYEIR-NGRLLGVCASVDNCRLFVGGIPKTKKREEILSEMR KVT----DGVVDVIVYPSAADKSK-NRGFAFVEYESHRAAAMARRKLLP-GRIQLWGHA-IAVDWAEPEVEVDEDTMATV -------------KILYVRNLMLQTT----------------------EETIEKEFNG-IRPG----------------- --------------------SVERVKKIRDYAFVHFAQREDAVN--AMGALNG---KLVDGS-----PIEVTLAKPVDKD SYVRYTRGTGGRG-ASLLQPDYAA--------------------YTLGQVYDPS-A------AYLGPPVFYAPQAYAAVP GQFRFPAAKAHVGGRGLIRTPSVREIYMTVPVGAAGV-RGLGG-RGYLAYAAGIGAGG-----GASYSLKADKQVEEKLY DLLPGMELT------------------------PMNPGAMNLK-A-AAKP-----ATQVLEELCQKNNWGQPVYQLHSAI GPDQRQLFLYKITIPALATQ-------------------YPNVHPFTPAKLC---AAVEEAKVHAAEHTLQTLGL----- --------------------------------------------QTEVAADASCATAATVASVTFPG--------YALAS PG-ASAVVSQLK---QAVSLGQDLTAYTTYEGYPAFA-VAARHTDGYGVF-------- >Oryzias_latipes_A1CF_a -------------------------------------------------------------------------------- --------------------------------------------------MESNQKP----------------------- -----------SGDALAG-----------------------------MQKEAALRALIQRTGYQLQQENGQRRYGGPPPG W---DGPHPERGS-----EIFVGKLPRDLF-EDELVPLCEKFGKIYEVRMMMDFNG-NNRGYAFVTFSNKQEAKTAMKQL --------------------------------------NNYEIR-NGRLLGVCASVDNCRLFVGGIPKIKKRDEILTEMK KVT----DGVVDVIVYPSAADKSK-NRGFAFVEYESHRAAAMARRKLLP-GRIQLWGYP-IAVDWAEPEVEVDDDTMATV -------------KILYVRNLMLQTT----------------------EETIEREFNS-LKPG----------------- --------------------AVERVKKIRDYAFVHFCQREDAIN--AMNALNG---KLVEGS-----PIEVTLAKPVDKD SYVRYTRGTGGRG-SSLLQTDYTA--------------------YTLGQVYDPS-A------AYLGAPVFYAPQAYTALP NQIRFPAAKAPVGGRGLIRSPSVREIYMTVPVGAAGV-RGLGG-RGYLAYSTGAGALGR-GSGGTSCGLKVCKQAEEKLY DLLPGMELT------------------------PMNPAAMNLK-ANALKP-----ATQVLEELCQKNNWGQPVYQLHSAI SPEQRQLFLYKITIPALASQ-------------------YPNLHPFTPAKLC---AAVEEAKVHAAEYTLQTLGL----- --------------------------------------------QSDGTADA---TAAAMTSVAFPG--------YTLAS PVSSAAVASQLK---EAASLGQELTAYAAYEGYPAFA-VAARHTDGYGVF-------- >Ciona_intestinalis_A1CF -------------------------------------------------------------------------------- -------------------------------------------------MIANNQQSVSES------------------- ----------SNPEPLCNN----------------------------PAKEAALHALCQKTGYTIKQENGQRKYGGPPPH W---NDVIPGKGC-----EVFVGKLPRDLY-EDELVPVLEKCGRIYELRLMMDFNG-NNRGFAFVKYCAASEARAALKDL --------------------------------------NNFEIR-KGRLLGVCKSVDNCRLFVGGIPKTKQKEEILIEMK KVT----EGVCDVIVYPSAADKQK-NRGFAFVEYQDHHTAAMARRKLMH-TRPQIWGHP-IAVDWAEPEVEVDDDIMATV -------------KILYVRNLMLNTT----------------------EEQLEAEFSALVPSG----------------- --------------------SIERVKKIRDYGFVHFNTRENAIK--CLKQLNG---KILDGS-----PMEVTLAKPVDRE TYVRYTRAANRV-VETQEPLTIPG---------------------YVATTYDPRFDPASAAYSYAGGPIYY--GVPYG-- ATTIPTLASSPRFAVPPLRGGVPQVPGMVTQIGAAGVPLGIPG--ATTGIAGA---QGR------GISLRGRNR-AAEKY DLMPDMVLT------------------------PTNPLSLKPS--QLQKS-----PIQLLEEYCMKMSLGNPDYKLHSAD GQNGRQLFLYRVEIPGLSSSQSQQDTSYNPN----QSAQAKPN-QFTPTKLC---TSLDVAKEIAASHVLDSLSG----- --------------------------------------------DDVTTDDVKPDVEQVYVTDNIPT----------VGT GINGDVNGYAMY---NGAVTDSDYSSFQLYNSTVTYPGIATTATDAYGPY-------- >Ciona_savignyi_A1CF -------------------------------------------------------------------------------- --------------------------------------------------SQANHKSVNDS------------------- ----------SNPEPLCIN----------------------------PAKEAALHALCQKTGYTIKQENGQRKYGGPPPH W---NDAIPGKGC-----EVFVGKLPRDLY-EDELVPVLERCGRIYELRLMMDFNG-NNRGFAFVKYCACSEARAALKDL --------------------------------------NNFEIR-KGRLLGVCKSVDNCRLFVGGIPKTKQKDEILIEMK KVT----EGVVNVIVYPSAADKQK-NRGFAFVEYQDHHTAAMARRKLMH-TRPQIWGHP-IAVDWAEPEVEVDEDVMATV -------------KILYVRNLMLNTT----------------------EEQLEAEFSALVPAG----------------- --------------------SIERVKKIRDYGFVHFNTRENAIT--CLKKLNG---KLLDGS-----PMEVSLAKPVDRE TYVRYTRAANRVPLDSQEPLAIPG---------------------FVPATYDPSFK---VVFLYAGGPIYYTTGVPYG-- AATIPTLTATPRFAMPSIRGGVTQVPGMVTQIGAAGVPLGIPG--ATTGISGG---QGR------GPVQ-------PEKY DLLPDMVLT------------------------PTNPLSLKPS--QLQKS-----PIQLLEEYCMKMSLGNPEYKLHSAE GQNGRQLFLYRVDIPGFSS----------------QSVSAKPSSQFTPTKLC---ISLDVAKEIAASHVLENLS------ -----------------------------------------------IADD----------------------------- ---------------------------------------------------------- >Nematostella_vectensis_A1CF -------------------------------------------------------------------------------- --------------------------------------------------ME----------ESG--------------P EQV---------TDGVTG-----------------------------TPKEAALRALMERTKFPIRQCNGQRRYG-PPPG W---DRPIPPRGC-----EVFVGKIPRDLY-EDELVPVFETAGPIYEVRLMMDFNG-QNRGYAFVVYTSKDDAKRCVKTL --------------------------------------NNYEIR-KGKCIGVCSSVDNCRLFVGGIPKKVKKDEIMAEVS KVT----DNVVDVIVYPSAQDKTK-NRGFAFVEYISHRDAAMARRKLMT-GKIQLWGHQ-IAVDWAEPEQEVDQEIMDQV -------------KVLYARNLLLSTT----------------------EETIEQAFSK---FG----------------- --------------------EVERVKKIKDYCFIHFRTKEQARD--AMEAMNET---ELDGN-----EIEVTLAKPVDKD HR---------------------------------------------------------------------SPLLFRG-- ----------YYGTPSMRPG----------------------------------------------------------FY G---------------------------------------------DYKK-----SQEILEDVCQKNQWGSPVYTLHSTL GPQEVQLFLYKVSIPGLAT-------------------------QYQPPKLC---RTVEEAKNYAAEHTLQQLG------ -------------------------------------------------------------------------------- -ISLEGMSR------------------------------------------------- >Homo_sapiens_HNRNPR -----------------------------------------------------------------MANQVNGNAVQLKEE EEPMDTSSVT------HTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDLDERAIDALREFNEEGALSVLQQFKESDLS HVQNKSAFLCGVMKTYRQ--REKQGSKVQ--------------ESTKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPD SVY-SGVQPGIGT-----EVFVGKIPRDLY-EDELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLC --------------------------------------DSYEIR-PGKHLGVCISVANNRLFVGSIPKNKTKENILEEFS KVTG-LTEGLVDVILYHQPDDKKK-NRGFCFLEYEDHKSAAQARRRLMS-GKVKVWGNV-VTVEWADPVEEPDPEVMAK- ------------VKVLFVRNLATTVT----------------------EEILEKSFSEFGKLE----------------- -----------------------RVKKLKDYAFVHFEDRGAAVK--AMDEMNG---KEIEGE-----EIEIVLAKPPDKK RKERQAARQASRS--------------------------------------------------TAYEDYYYHPPP-RMPP PIRGRGRGGG----RGGYGYPPDYYGYEDYYDDY----------------------------------------YGYDYH DYRGGYEDPYY----------------------------------------------GYDD-GYAVRGRGGG-RGGRGAP PPPRGRGAP----------------------------------PPRGRAGYSQRGAPLGPPRGSRG-----GRGGP---- ----------------------------------------------AQQQRGRGSRGSRGNRGGNVGGKRKADGYNQ--P DSKRRQTNNQQ-NWGSQPIAQQPLQQGGDYSGNY--GYNNDNQEFYQDTYGQ-QWK-- >Mus_musculus_HNRNPR -----------------------------------------------------------------MANQVNGNAVQLKEE EEPMDTSSVT------HTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDLDERAIDALREFNEEGALSVLQQFKESDLS HVQNKSAFLCGVMKTYRQ--REKQGSKVQ--------------ESTKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPD SVY-SGVQPGIGT-----EVFVGKIPRDLY-EDELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLC --------------------------------------DSYEIR-PGKHLGVCISVANNRLFVGSIPKNKTKENILEEFS KVT----EGLVDVILYHQPDDKKK-NRGFCFLEYEDHKSAAQARRRLMS-GKVKVWGNV-VTVEWADPVEEPDPEVMAK- ------------VKVLFVRNLATTVT----------------------EEILEKSFSEFGKLE----------------- -----------------------RVKKLKDYAFVHFEDRGAAVK--AMDEMNG---KEIEGE-----EIEIVLAKPPDKK RKERQAARQASRS--------------------------------------------------TAYEDYYYHPPP-RMPP PMRGRGRGG-----RGGYGYPPDYYGYEDYYDDY----------------------------------------YGYDYH DYRGGYEDPYY----------------------------------------------GYDD-GYAVRGRGGG-RGGRGAP PPPRGRGAP----------------------------------PPRGRAGYSQRGAPLGPPRGSRG-----GRGGP---- ----------------------------------------------AQQQRGRGSRGARGNRGGNVGGKRKADGYNQ--P DSKRRQTNNQQ-NWGSQPIAQQPLQQGGDYSGNY--GYNNDNQEFYQDTYGQ-QWK-- >Canis_familiaris_HNRNPR -----------------------------------------------------------------MANQVNGNAVQLKEE EEPMDTSSVT------HTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDLDERAIDALREFNEEGALSVLQQFKESDLS HVQNKSAFLCGVMKTYRQ--REKQGSKVQ--------------ESTKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPD SVY-SGVQPG