>HUMAN_CBX1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----MGKKQNK--------------KKVEEVLEEEE-----EEYVVEKVLDRRVV-KGKVEYLLKWKGFSDEDNTWEPEE NLDCPDLIAEFLQSQKTAHETDK---SEGGKRKAD--------------------------------------SDSEDKG EESKPKKKKE---------------------------------------------------------------------- --ESEKPR------------------------------------------------------------------------ ------------------------GFARGLEPERIIGATDSSGELMFLMKWKN--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SDEADLVPAKEAN------------------------------------ ----------------VKCPQVVISFYEERLTWHSYPSEDDDKKDDKN-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >MOUSE_CBX1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----MGKKQNK--------------KKVEEVLEEEE-----EEYVVEKVLDRRVV-KGKVEYLLKWKGFSDEDNTWEPEE NLDCPDLIAEFLQSQKTAHETDK---SEGGKRKAD--------------------------------------SDSEDKG EESKPKKKKE---------------------------------------------------------------------- --ESEKPR------------------------------------------------------------------------ ------------------------GFARGLEPERIIGATDSSGELMFLMKWKN--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SDEADLVPAKEAN------------------------------------ ----------------VKCPQVVISFYEERLTWHSYPSEDDDKKDDKN-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >RAT_CBX1 MEGRTVSVSVLGSRRAKPPKVFHRRPLGKSSSPEMEPTVIINSHPDTPAIRFAPLPEHPTASRVNSGCVLLLCKDSLKPK PLISPSVAVYVYSDIAHSNKGTMKAALADRQQKNRKLSILKWFLVWALQASCDSGRSKGTEEFLVVNFLKTLTLQKPGSI SNNHCSQLTSFLKRPLFRKKTELSSIPGEASSSELQLYDLSEEADLCTHKGRTESSNLQRLRSLLNANYISAAFSILPQV FFASLNNTGTNSPGEGPELSGVQRLKNLAFLNTPRVFEETLPPDNLACPSNSCFTFQSPDADSGFSFRVSRRRPSARREA APDGPILSVQDAPPLKTRALSGDRRSAENHRHAQASAEIHIFPEIAWGVRGGAQGPRPGEVHSGAAFRPRPSGGPINAQE VFKGRRKHLGILKALDDLDSPGLNLGGCNSPSEMSRALPVKFGKATDYPSKKHTKLTTPQTVVKPKAGPCIALRRVVASA QCRRRAAQSENLFCSAEGRAVGRACGTPLHLDDRLEATRLFAPLGATPWDRLTQRARSATPIPLGLSGAATSSVTLHTRK LAGTMGKKQNK--------------KKVEEVLEEEE-----EEYVVEKVLDRRVV-KGKVEYLLKWKGFSDEDNTWEPEE NLDCPDLIAEFLQSQKTAHETDK---SDGGKRKAD--------------------------------------SDSEDKG EESKPKKKKE---------------------------------------------------------------------- --ESEKPR------------------------------------------------------------------------ ------------------------GFARGLEPERIIGATDSSGELMFLMKWKN--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SDEADLVPAKEAN------------------------------------ ----------------VKCPQVVISFYEERLTWHSYPSEDDDKKDDKN-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HUMAN_CBX2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MEELSSVGEQ------VFAAECILSKRLR-KGKLEYLVKWRGWSSKHNSWEPEE NILDPRLLLAFQKKEHEKEVQ-NRKRGKRPRGRPRKLTAMSSCSRRSKLKEP-----DAPSKSKSSSSSSSSTSSSSSSD EED----DSDLDAKRGPRGRETH------------------------------------------------PVPQKKAQI LVAKPELKDPIRKKRGRKPLPPEQKATRRPVSLAKVLKTARKDLGAPASKLPP-PLSAPVAGLAALKAHAKEACGGPSAM ATPENLASLMKGMASSPGRGGISWQSSIVHYMN-RMTQSQAQAASRLALKAQATNKCGLGLDLKVRTQKG-ELGMSPPGS KIPKAPSGGAVEQKVGNTGGPPHTHGASRVPAGCPGPQPAPTQELSLQVLDLQSVKNGMPGVGLLARHATATKGVPATNP APGKGTGSGLIGASGATMPT-----------------------------------DTSKSEK---LASRAVAPPTPASKR DCVKGSATPSGQES-RTAPGEARKAATLPEMSAGEESSSSDSDPDSA--------------------------SPPSTGQ NPSVSVQTSQDWKPTRSLIEHVFVTDVTANLITVTVKESPTSVGFFNLRHY----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >MOUSE_CBX2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MEELSSVGEQ------VFAAECILSKRLR-KGKLEYLVKWRGWSSKHNSWEPEE NILDPRLLLAFQKKEHEKEVQ-NRKRGKRPRGRPRKHTVTSSCSRRSKLKEP-----DAPSKSKSSSSSSSSTSSSSSSD EEE---DDSDLDSKRGPRGRETH------------------------------------------------PVPQKKAQI LVAKPELKDPIRKKRGRKPLPPEQKAARRPVSLAKVLKTTRKDLGTSAAKLPP-PLSAPVAGLAALKAHTKEACGGPSTM ATPENLASLMKGMAGSPSRGGI-WQSSIVHYMN-RMSQSQVQAASRLALKAQATNKCGLGLDLKVRTQKGGELGGSPAGG KVPKAPGGGAAEQQRGNH-------------SGSPGAQLAPTQELSLQVLDLQSVKNGVPGVGLLARHAPA-KAIPATNP ATGKGPGSGPTGANMTNAPT-----------------------------------DNNKGEK---LTCKATALPAPSVKR DTVKSVAASGGQEG-HTAPGEGRKPPALSELSTGEENSSSDSDPDST--------------------------SLPSAAQ NLSVAIQTSQDWKPTRSLIEHVFVTDVTANLITVTVKESPTSVGFFNLRHY----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >RAT_CBX2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MEELSSVGEQ------VFAAECILSKRLR-KGKLEYLVKWRGWSSKHNSWEPEE NILDPRLLLAFQKKEHEKEVQ-NRKRGKRPRGRPRKHTVMSSCSRRSKLKEP-----DAPSKSKSSSSSSSSTSSSSSSD EEEEDDDDSDLDSKRGSRGRETH------------------------------------------------PVPQKKAQI LVAKPELKDPIRKKRGRKPLPPEQKAARRPVSLAKVLKTTRKDLVTSAPKLPP-PLSAPVAGLAALKAHTKEACGGPSTM ATPENLASLMKGMAGSPSRGGISWQSSIVHYMN-RMSQSQAQAASRLALKAQAANKCSLGPDLKVRTQKG-ELGVNPAGS KVPKAPGSVAAEQQRGNN-------------SGSPGSQLPPTQELSLQVLDLQSVKNGVPGVGLPARHATATKAIPATNT ATGKGPGSGPTGVNVTNAPT-----------------------------------DTSKGEK---LTCKTAALPAPSVKR DAAKSIAASGGQEG-HTVPGEGQKPPALCELSTGEENSSSDSDPDSS--------------------------SLPSAGQ NLSVAVQTSQDWKPTRSLIEHVFVTDVTANLITVTVKESPTSVGFFNLKHY----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HUMAN_CBX3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------MASNKTT -LQKMGKKQN---------------GKSKKVEEAE-P----EEFVVEKVLDRRVV-NGKVEYFLKWKGFTDADNTWEPEE NLDCPELIEAFLNSQKAGKEK------DGTKRKSL--------------------------------------SDSE--S DDSKSKKKRD---------------------------------------------------------------------- --AADKPR------------------------------------------------------------------------ ------------------------GFARGLDPERIIGATDSSGELMFLMKWKD--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SDEADLVLAKEAN------------------------------------ ----------------MKCPQIVIAFYEERLTWHSCPEDEAQ-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >MOUSE_CBX3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------MASNKTT -LQKMGKKQN---------------GKSKKVEEAE-P----EEFVVEKVLDRRVV-NGKVEYFLKWKGFTDADNTWEPEE NLDCPELIEAFLNSQKAGKEK------DGTKRKSL--------------------------------------SDSE--S DDSKSKKKRD---------------------------------------------------------------------- --AADKPR------------------------------------------------------------------------ ------------------------GFARGLDPERIIGATDSSGELMFLMKWKD--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SDEADLVLAKEAN------------------------------------ ----------------MKCPQIVIAFYEERLTWHSCPEDEAQ-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >RAT_CBX3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------MASNKTT -LQKMGKKQN---------------GKSKKVEEAE-P----EEFVVEKVLDRRVV-NGKVEYFLKWKGFTDADNTWEPEE NLDCPELIEAFLNSQKAGKEK------DGTKRKSL--------------------------------------SDSE--S DDSKSKKKRD---------------------------------------------------------------------- --AADKPR------------------------------------------------------------------------ ------------------------GFARGLDPERIIGATDSSGELMFLMKWKD--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SDEADLVLAKEAN------------------------------------ ----------------MKCPQIVIAFYEERLTWHSCPEDEAQ-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HUMAN_CBX4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MELPAVGEH------VFAVESIEKKRIR-KGRVEYLVKWRGWSPKYNTWEPEE NILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSS--TDNRAKLDLGAQGKGQGHQYELNS KKHHQYQPHSKERAGKPPPPGKS----------------------------------------------GKYYYQLNSKK HHPYQPDPKMYDLQYQGGHKEA-----------------PSPTCPDLGAKSHP---PDKWAQGAGAKGYLGAVKPLAGAA GAPGKGSEKGPPNGMMPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYME-NGMQAVKIKSGEVAEGEARSPSHKKR AADERHPPADRTFKKAAGA-EEKKVEAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEA-------------FGEQPLQLT TKPDLLAWDPARNTHPPSHHPHPHPHHHHHHHHHHHHAVGLNLS--HVRKRCLSETHGEREPCKKRLTARSISTPTCLGG SPAAERPADLPP-AAALPQP--EVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKP PAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >MOUSE_CBX4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MELPAVGEH------VFAVESIEKKRIR-KGRVEYLVKWRGWSPKYNTWEPEE NILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSS--ADNRAKLELGTQGKGQGHQYELNS KKHHQYQPHSKERSGKPPPPGKS----------------------------------------------GKYYYQLNSKK HHPYQPDPKMYDLQYQGGHKEA-----------------PSPTCPDLGTKSHP---PDKWAHGAAAKGYLGAVKPLGGGA GAPGKGSEKGPPNGMTPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYME-NGMQAVKIKSGEAAEGEARSPSHKKR AAEERHPQGDRTFKKAAGASEEKKAEVPCKRREEEALVSGDAQPQDLGSRKLSPTKEA-------------FGEQPLQLT TKPDLLAWDPARSSHPPAHH------HHHHHHHHHHHTVGLNLS--HARKRCLSETHGEREPCKKRLTARSISTPTCLGG SPVSEHPANVSPTAASLPQP--EVILLDSDLDEPIDLRCVKMRSDAGEPPSTLQVKPEAP-----AVAAVVAPAPASEKP PAEAQEEPVEPLSEFKPFFGNIIITDVTANCLTVTFKEYVTV-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >RAT_CBX4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MELPAVGEH------VFAVESIEKKRIR-KGRVEYLVKWRGWSPKYNTWEPEE NILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSS--ADNRAKLELGTQGKGQGHQYELNS KKHHQYQPHGKERSGKPPPPGKS----------------------------------------------GKYYYQLNSKK HHPYQPDPKMYDLQYQGSHKEA-----------------PSPTCPDLGAKSHP---PDKWAHGAAAKGYLGAVKPLGGGA GAPGKGSEKGPPNGLTPAPKEAVAGNGIGGKMKIVKNKNKNGRIVIVMSKYME-NGS----------------------- -----MLQSDRTFKKAAGASEEKKAEVPCKRREEEALVSGDPQPQDLGSRKLSPTKEA-------------FGEQPLQLT TKPDLLAWDPARSSHPPAHH------HFHHHHHHHHHTVGLNLS--HARKRCLSETHGEREPCKKRLTARSISTPTCLGG SPVSEHPANVSPTAASLPQP--EVILLDSDLDEPIDLRCVKMRSDAGEPPSTLQVKPEAP-----AVAAVVAPATAAEKP PAEAQEEPAEPLSEFKPFFGNIIITDVTANCLTVTFKEYVTV-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HUMAN_CBX5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----MGKKTK---------------RTADSSSSEDE-----EEYVVEKVLDRRVV-KGQVEYLLKWKGFSEEHNTWEPEK NLDCPELISEFMKKYKKMKEGEN--NKPREKSESN-----------------------------------KRKSNFSNSA DDIKSKKKREQ--------------------------------------------------------------------- --SNDIAR------------------------------------------------------------------------ ------------------------GFERGLEPEKIIGATDSCGDLMFLMKWKD--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------TDEADLVLAKEAN------------------------------------ ----------------VKCPQIVIAFYEERLTWHAYPEDAENKEKETAKS------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >MOUSE_CBX5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----MGKKTK---------------RTADSSSSEDE-----EEYVVEKVLDRRMV-KGQVEYLLKWKGFSEEHNTWEPEK NLDCPELISEFMKKYKKMKEGEN--NKPREKSEGN-----------------------------------KRKSSFSNSA DDIKSKKKREQ--------------------------------------------------------------------- --SNDIAR------------------------------------------------------------------------ ------------------------GFERGLEPEKIIGATDSCGDLMFLMKWKD--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------TDEADLVLAKEAN------------------------------------ ----------------VKCPQIVIAFYEERLTWHAYPEDAENKEKESAKS------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >RAT_CBX5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----MGKKTK---------------RTADSSSSEDE-----EEYVVEKVLDRRMV-KGQVEYLLKWKGFSEEHNTWEPEK NLDCPELISEFMKKYKKMKEGEN--NKPREKSEGN-----------------------------------KRKSSFSNSA DDIKSKKKREQ--------------------------------------------------------------------- --SNDIAR------------------------------------------------------------------------ ------------------------GFERGLEPEKIIGATDSCGDLMFLMKWKD--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------TDEADLVLAKEAN------------------------------------ ----------------VKCPQIVIAFYEERLTWHAYPEDAENKEKESAKS------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HUMAN_CBX6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MELSAVGER------VFAAESIIKRRIR-KGRIEYLVKWKGWAIKYSTWEPEE NILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKAR--AQAEALRISDVHFSV-KPSASASSPKLHSSAAVHRLKKDI RRCHRMSRRPLPRPDPQGGS---------------------------------------------------PGLRPP--- ISPFSETVR--IINRKVKPREPKRNR---------------------IILNLKVIDKGA-GGGGAGQGAGALARPKVP-- ------SRNRVIGKSKKFSESVLRTQIRHMKFGAFALYKPPPAPLVAPSPGKAEASAPGPGLLLAAP------------- --------------------------------------AAPYDARSSGSSGCPS-------------------------- -------------------------------------------------------------PTPQSS-DPDDTPPKLLPE TVSPSAPSWREPEVLDLSLPPESAATSKRAPPEVTAAAGPAPPT------------------------------APEPAG A-SSEPEAGDWRPEMSP-CSNVVVTDVTSNLLTVTIKEFCNPEDFEKVAAGVAGAAGGGGSIGASK-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >MOUSE_CBX6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MELSAVGER------VFAAESIIKRRIR-KGRIEYLVKWKGWAIKYSTWEPEE NILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKAR--AQAEALRISDVHFSV-KPSASASSPKLHSSAAVHRLKKDI RRCHRMSRRPLPRPDPQGGS---------------------------------------------------PGLRPP--- ISPFSETVR--IINRKVKPREPKRNR---------------------IILNLKVIDKGP-GGGSTAQGTGALARPKVP-- ------SRNRVIGKSKKFSESMLRTQIRHMKFGTFALYKPPPAPLAPSTAGKADVASSGPGLLLATPA------------ --------------------------------------AAPFDAHSSSSSGCPS-------------------------- -------------------------------------------------------------PTLQSS-DPDDAPPKLLPE TLSRSVPNWRESEVLDLSIPPEAAATGQRVPPDVTGAADQALHT------------------------------ALEPTG AGSSEPEAGDWRPEMSP-CSNVVVTDVTSNLLTVTIKEFCSPEDFEKVAAGVAGATGGGGGTGPSK-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >RAT_CBX6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MELSAVGEW------VFAAESIIKRRIR-KGRIEYLVKWKGWAIKYSTWEPEE NILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLK---------------------PSASASSPKLHSSAAVHRLKKDI RRCHRMSRRPLPRPDPQGGN---------------------------------------------------PGLRPP--- ISPFSETVR--IINRKVKPREPKRNR---------------------IILNLKVIDKGP-GGGSTAQGTGALARPKVP-- ------SRNRVIGKSKKFSESMLRTQIRHMKFGTFALYKPPPAPLVPSTAGKADVASSGPGLLLATPA------------ --------------------------------------AAPFDAHSSSSSGCPS-------------------------- -------------------------------------------------------------PTLQSS-DPDDAPPKLLPE TISRSASNWRESEVLDLSIPPEAAATGQRVPPDVTAAAGQALHT------------------------------VLEATG TGSSEPEAGDWRPEMSP-CSNVVVTDVTSNLLTVTIKEFCSPEDFEKVAAGVAGATGGGGGTGPSK-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HUMAN_CBX7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MELSAIGEQ------VFAVESIRKKRVR-KGKVEYLVKWKGWPPKYSTWEPEE HILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQR-------------------------------------LYSMDL RSSHKAKGKEKL----------------------------------------------------------CFSLTCPLGS GSPEGVVK------------------------------------------------------------------------ --------AGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHS------------------------ ---------------------HRRELFLQEPPAPD------------VLQAAG-------------------EWEPAAQP P------------------------------------------------------------------------------- -------------------------------EEEADADLAEG--------------------------------PPPWTP ALP---------------SSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >MOUSE_CBX7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MELSAIGEQ------VFAVESIRKKRVR-KGKVEYLVKWKGWPPKYSTWEPEE HILDPRLVMAYEEKEERDRASGYRKRGPKPRRLLLQ-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------ESAAPD------------VVQTPG-------------------DWEPMEQA P------------------------------------------------------------------------------- -------------------------------EEEAEADLTNG--------------------------------PPPWTP TLP---------------SSEVTVTDITANSVTVTFREAQAAEGFFRDRNEKL--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >RAT_CBX7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MELSAIGEQ------VFAVESIRKKRVR-KGKVEYLVKWKGWPPKYSTWEPEE HILDPRLVMAYEEKEEKDRASGYRKRGPKPKRLLLQ-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------ESAAPD------------VLQATG-------------------DWEPVEQP P------------------------------------------------------------------------------- -------------------------------EEEAEADLTNG--------------------------------PPPWTP MLP---------------SSEVTVTDITANSVTVTFREAQAAEGFFRDRSGKL--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HUMAN_CBX8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MELSAVGER------VFAAEALLKRRIR-KGRMEYLVKWKGWSQKYSTWEPEE NILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQ------------------------AKAKAKTYEFRSDSARGI RIPYPGRSPQDLASTSRARE----------------------------------------------------GLRNMGLS PPASSTSTSSTCRAEAPRDRDRDRDRDRERDRERERERERERERERERERGTSRVDDKPSSPGDSSKKRGPKPRKEL--- ----PDPSQRPLGEPSAGLGEYLKGRKLDDTPSGAGKFPAGHSVIQLARRQDSDLVQCGVTSP----------------- -------------------------------------------SSAEATGKLAV-------------------------- -------------------------------------------------------------DTFPARVIKHRAAFLEAKG QGALDPNGTRVRHGSGPPSSGGGLYR-DMGAQGGRPSLIARIPV------------------------------ARILGD PEEES-----WSPSLTN-LEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >MOUSE_CBX8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MELSAVGER------VFAAEALLKRRIR-KGRMEYLVKWKGWSQKYSTWEPEE NILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQ------------------------AKAKAKTYEFRSDSTRGI RIPYPGRSPQDLASTSRARE----------------------------------------------------GLRNTGLP PPGSSTST---CRADPPRDRDR------------------------ERDRGTSRVDDKPSSPGDSSKKRGPKPRKEP--- ----LDPSQRPLGEPSAGLGEYLKGRKLDETSSGTGKFPAGHSVIQLARRQDSDLVQYGVTSP----------------- -------------------------------------------SSAEASSKLAV-------------------------- -------------------------------------------------------------DTFPARVIKHRAAFLEAKG QGALDPGGARVRHSSGTPASVGSLYR-DMGAQGGRPSLIARIPV------------------------------ARILGD PEEES-----WSPSLTN-LEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >RAT_CBX8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MELSAVGER------VFAAEALLKRRIR-KGRMEYLVKWKGWSQKYSTWEPEE NILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQ------------------------AKAKAKTYEFRSDSTRGI RIPYPGRSPQDLASTSRARE----------------------------------------------------GLRNTGLP PPGSSTST---CRADPPRDRDRDRDR--------------------ERDRGTSRVDEKPSSPGDSSKKRGPKPRKEL--- ----LDPSQRPLGEPSDGLGEYLKGRKLDETPSGIGKFSAGHSVIQLARRQDSDLVQYGVTSP----------------- -------------------------------------------SSAEASGKLAA-------------------------- -------------------------------------------------------------DTFPARVIKHRAALLEAKG QGALDPGGTRVRHSSGTPGSVGSLYR-DMGAQGGRPSLIARIPV------------------------------ARILGD PEEES-----WSPSLTN-LEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HP1b_Drosophila -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------M----AEFSVERVEDKRTV-NGRTEYYLKWKGYPRSENTWEPVE NLDCPDLIANFEESLKNNKK-------ETKKRLSTS-------------------------------------STPESIR SKRKSFLEDDTE-------------------------------------------------------------------- --EQKKLI------------------------------------------------------------------------ ------------------------GFERGLEASKILGATDSSGHLMFLMKWKG--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SDHADLVPAKLAN------------------------------------ ----------------TRCPQVVIQFYEERLTWHTGSGNGNGNTNSVNLGSSGGLGSVGGSGAGDDTAPGSVGTTGGGSN IDGGDEEDPEPASPIGSINQDENIKPDESSELDNGQPDADD--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HP1c_Drsophila -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------MVKNEP------NFVVERIMDKRITSEGKVEYYIKWRGYTSADNTWEPEE NCDCPNLIQKFEESRAKSKKRGEKKPKCEEIQKLRGYER------------------------GLELAEIVGATDVTGDI KYLVRWQFCDEFDLVPS--------------------------------------------------------------A QIVEKDPQ------------------------------------------------------------------------ ------------------MLIDYFQKMAPYSRHIAMRMKGVPEELRLAASRTSYPHIS---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SAPVEVPPEVDQS----------------------------------AE LAGHLGGIAPQVDQAPQHHAPMDLANDTDDLASVSYSIPVPGVGDIAIDVPMAENQ------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HP1e_Drosphila -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M DSDADGGETVS--------------NFSENSTDFEET----EEYIVERILDRRHY-MGQLQYLVKWLDYSDEDNTWESAA DLDCHSLIDSIESQK--SLKRGQ----ELNN------------------------------------------------- -QYETKAKR--------LKIDPCL-------------------------------------------------------- --VVDS-------------------------------------------------------------------------- ------------------------PFNHGFTAQEILKGAKNNGEISFLIRFWH--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------LDQPQVVPSGIAY------------------------------------ ----------------VEIPQMVLKFYENHCNFHDYLNNYIS-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HP1b_seaurchin -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----MGKKQRKPEDGPEPEGEENEEKKTEGESEEEEE----EVYQVEKVVDKRIH-KGRVEYLLKWKGYGDDESTWEPQD NLECPDLIEAYEKKIREKEALKR---KSAQNVAAG------------------------------------DVAAKKRRK EEAAATEKRKDSSGPSKDGKQTKQ-------------------------------------------------------- --DEKKYR------------------------------------------------------------------------ ------------------------GFDRGLDPERIIGATESNNELLFLMKWKN--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------NNEADLVRAKEAN------------------------------------ ----------------HRCPQIVIQFYEERLTWHSEDDEEDKR------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HP1b_Cionaintestinalis(1) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MNDIGEN--------VYQAEKISKKRSK-KGRDEFFVKWKGWSTRHSTWEPKE NILDQTLIDMFEAGETNSKRKGRKQK------------------------------------------------------ -RQRPVWN------------------------------------------------------------------------ -EPEKTEP------------------------------------------------------------------------ -----------------------AETPSGSS-VVKMEIKKENKEIDK--------------VDCDVIE------------ -------------------------------------------EKVETIVDEPE-------------------------- ------------------------------------------------------------VDTKKKCFPMKNVS------ ---------------------------------LLRRSIGRPRK--------------------------------KVVS QEGKPLVTSN-----NWNFNEITVTDVNLHSQNVTFLECERGGVFIDPYINT---------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >HP1b_Cionaintestinalis(2) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----MGKKK-------------MDEPVALIENEEEAG----EEYEVEKVIDKRIY-KGKVQYLIKWKGFSDADNTWEPDE NLECPDLISQFESTNIKKTNNKE---KEKEIVKD----------------------------------------DKKRKI SETKEGTKK------SK-----TA-------------------------------------------------------- --DELRPK------------------------------------------------------------------------ ------------------------GFARGLKPEKIIGATDSGGQLTFLMKWDG--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SDEADLVSSAEAN------------------------------------ ----------------VKCPQVVIKFYEERLTWHQSTPSPDDQS------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >jellyfish(a) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MG KKKGKGKRETD--------------ETTEPVPTGEVE----EEYEVEKVMDKRVI-NGGIEYLLKWKGYPDSENTWESEE GLQCPELIEEYEKKKKASSKPSN----ILDKSALFI-------------------------------------SSFSHSV EKGESKPKKRKVNAYEELGMKAVE-------------------------------------------------------- --VEDASKD----------------------------------------------------------------------- ---------------------DVDPIAEGWEADTILGATEVDGQIHFLIQWKS--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------TDRADLIPSKVAN------------------------------------ ----------------LKWPQIVIKFYEERVTWTQGEGGQVSAK------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >jellyfish(b) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MNKGGRAAG------IYAAETILKERVR-DGKVWYFIKWKGYSQRYNTWEPEE NVLDPRLLKAYQERLALSEKKVKRKKVKPSTEVGGTEE---------------------GPLDVDVDSDSGTEVNIIDNE PEPATISPE----------------------------------------------------------PIPEETTQPTTTD EEPKKKKRKQKRKLKIPEKCSS-----------------------EMVHLANDEPSTNFEKTETGG-------------- -----------------------LSIPEDSPKAATGEIEMKDLTLEIPTPRESCQFPGPVSVSPRVAT------------ -------------------------------------------AHSPPPISPRV-------------------------- ------------------------------------------------------------TPEKTPTASTSNGHG----- ---IPSASVSLLGILEKKKESPKAPEVSSVSPRPRDEHTAKGEP--------------------------------KIVA SERKPNVTMSRYSHFDFLANSIIITDVTTERGMITIKECSACGDFFGPEPDRPE-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >jellyfish(c) -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------MDVTSTEVAAEAKENEPIPPAEGIFAAECILKKRTR-KGQIEYLVKWRGWSAKYNTWEPAE NILDGRLLLAFENSRRRRGKKPRWQRGISETAKKTKSD---------------------SGTSYNIRSDPGLKWGFEGAR RSGRPMRESESSDSSYNSDLTITDGNITSSASSYSSISPEPTVPDQEFTHSNPTVHSAVKQSHIATLSTPVSCAETQTQQ PKPEKSKPTPHNIREILKTPSPDPPK-------------------QLFNLSGSSPSDNFLKINSPKRASDFQFVPVKSPG GRETGLRGTGSQSGVDIANKHETAKIPTDSA-LVYKDFQFRHHKEEKDHHRKVSVTGGRTSTETNVLD------------ -------------------------------------------KKDSELKPNRE-------------------------- ------------------------------------------------------------LSNGDKRYKIPRLSSSTAET TRVSEIKSIPSFKVTKSPEPAQKNGTTTGVFESARIPSAGESAT--------------------------------TILP PETRDFRFWH-----KPLIDQIVITDVTANFVTVTVKECCTDKGFFRERQTGV--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >STICKLEBACK_CBX1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MSLTTEPPNDVPAVTQGFNDQSNY VP-CSDPSEPE--------------SKMAAVEKDKKP----DEYVVERVLNRRVV-KGRVEYLLKWKGFSEEDNTWEPDD NLDCPDLIAEFLQSQKSAHD---------GKRKAA--------------------------------------GDAE--G DESKTKKKKD---------------------------------------------------------------------- --DTEKLR------------------------------------------------------------------------ ------------------------GFARGLDPERIIGATDSTGELMFLMKWKN--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SDEADLVPAKEAN------------------------------------ ----------------GKCPQVVISFYEERLTWHSYSAE-GEKKEEKN-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >TETRAODON_CBX1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----SDPAES---------------TKVTSAEKEKKP----DDYVVEKVLNRRVV-KGRVEYLLKWKGFSDEDNTWEPED NLDCPDLIAEFLQSQKSAQE---------GKRKAG--------------------------------------GEVE--G EESKAKKKKD---------------------------------------------------------------------- --DPEKLR------------------------------------------------------------------------ ------------------------GFARGLVPERIIGATDSTGELMFLMKWKN--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SDEADLVPAKEAN------------------------------------ ----------------VKCPQVVISFYEERLTWHSYPTE-DEKKEDKN-------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >ZEBRAFISH_CBX2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MEELSAVGEQ------VFDAECILNKRTR-KGKLEYLVKWRGWSSKHNSWEPQE NLLDPRLLVAFNKREQEKELL-ISKKGKRPRGRPRKIMET--IPVVSKSSSS------SSSSSSSGSSSSSSSSSSSTDD DDE---DDHNMTPKPIPRPREHL------------------------------------------------PVPQKKAQI VVAKPGPP----KKRGRKALPPELKAIRQVKGTRKILKPISRDSDLRGIKKPLMPASFTYTGLNRTSGREPMAMHNRGSF THKSSLSSLGRSIGSVSSPPTLNRSPQTKSASDFKLSVSDMNSGLDPKTPTCKSPGVAALNLHSSN--GQTCPQLSPTVP K-------DQTLLQRSASLP-----------KSPSSSFSSLKTPSSLQALNLQSVNKTVQGNGTDLKTSPHSGRKSSGFN TSSAPNTPSKFQT--SQQAL-----------------------------------KSPQKLKADDLAERLGKKSQARTEK ILPTEGRDSQPAQDRPSSKDPSKQSKTLSELSTGEEGSSSDTDHDS---------------------------SFPRDSH DLSISVQAGQDWRPTRSLIEHVFVTDVTANLVTVTVKESPTSVGFFSIRNY----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >FUGU_CBX2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MEELSAVGEQ------VFDAECILNKRLR-KGKLEFLVKWRGWSAKHNSWEPQE NILDPRLLAAFNKKEHEKELL-MRKKGKRPRGRPRKILIQENLPEPEKSSSS-----SSGSSSSSSDSSSSCSSSSSSED DDE---DEDGGQMNPSIRTRDP-------------------------------------------------PVPQKKAQI VMAKQEPP----LKRSRKPLPPDVKDFPQNKGPRRVLKTYQESSLPGTIKKPVHPASFTFMGFHRGSR-DPAGVQTRSPL TPAS-----------SAGAQSVGRSGPSRSTDEGKTSGSGPGSGAALALKADAAKGKEAQNSNSARISSPGTVQQTPGSP SGPKRPPGPALLQRVPTSRA-----------APSLPSRTSSG--SGLQPLNLQ--SKLVPARDATGNGTGPVRNAAAKKS LVAPTREYS------PPGRL-----------------------------------QSRKNLQ--DKVPENTEIQNPKVQT RLDKSSIQKPAEV--QQDRSAPKDGKKKNELSAGEDESSSESDQD----------------------------------- QNASVAVQNQDWKPMRSLIEHVFVTDVTANLVTVTVKESPTSVGFFSLRNY----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >MEDAKA_CBX2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MEELSAVGEQ------VFDAECILNKRVR-KGKLEFLVKWRGWSSKHNSWEPQE NILDPRLLAAFNKKEQEKELL-MLKRGKRPRGRPRKILVRTSRRAAPRLSDSDRTNDSLPEPPKSSTSSSAMSSSSEDED EDE---DSHLQQTAPTVRTRDHD------------------------------------------------PVPQKKAQI LMAKPDPS----KKRRG-----EAKELQQNKAPP---KTDKGPDLPGGPHKPVQPPGFAFLGFHRGSAREAVGAQNRSPL AQGGGVKNAPGSA--GPGRSSVQTSLPLNKSGQSRPSAVS----SGASLDLKKAKGVAALHLNPSKHPLQGAAQHTPGGQ R--KAHTPLSTMQRMLSTKT-----------GTPPPKNPPSNPGSGPQPLNLH--HKLSQGSGTAGNAQ-RGAATPAKKA ATPAQVHHDD-----PQRRP-----------------------------------AARKSQP------------------ --DKSG--SEVQK--QPERS---KKPRMTEMSTGEEESSSDSDHD----------------------------------A SFNGAAVQNQDWKPTRSLIEHVFVTDVTANLVTVTVKESPTSVGFFSLRNY----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >STICKLEBACK_CBX2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MEELSAVGEQ------VFDAECILNKRLK-KGKLEFLVKWRGWSSKHNSWEPQE NILDPRLLAAFNRKEQEKELL-ILKKGKRPRGRPRKILEN--VPDAQRSSSS-----SSGSSWSSDSSSSCSSDSSSLDD AED---DERMALEPPGVRTRDL-------------------------------------------------HPPQKKAQI LVAKPELA----KKWISQPLSLDARELQQCKGPR-------DGELPGAIKKPVNPAGFTFMGFHRGIPRDAAAGPTRGSP GPGGSVKHCVRSV--QPAPLSLSRPVPSRSLGEGKLPVSG-GTDTDPKASAGKSKGVAALNLNTPKHPAQGTAYHSPSPP TGHKKPPPPG------GKVA-----------AALPPNNAPAGQCPGPPPLNLQ--GRRAQSGGVAGGP--RSAAHPARQT PVLQNQEYNPAKGPAAPGRL-----------------------------------QTRKSQPGADKVKEATGTPTPRVQA RLEPSGALTEVPT--PLERSEGKK-AKMNDMSTGEDESCSDSDQDP---------------------------PYVVGGV RAVASQNLNQDWKPTRSLIEHVFVTDVTANLVTVTVKESPTSVGFF-MRHY----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >TETRAODON_CBX2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------MEELSAVGEQ------VFDAECILNKRLR-KGKLEFLVKWRGWSAKHNSWEPQE NILDPRLLAAFNKKEQEKELL-MRKKGKRPRGRPRKVLVSTAGSAGPTGVRL-----SCPVFQENLPGPGKSSSSSSG-- --------YEGQVNPSIRTRDH-------------------------------------------------PVPQKKAQI VMAKPEPP----PKRSRKPPPPDAS-----KGPRRVLKTFPEPGPPGTIKKPVHPASFTFMGFHRGS-----GGPIRSPL SSRS-----------SGG---VGRSGPGRNPDEGRTLES------RLAPKADT---KEAQNPTRTRSPSQGSAQHGPGSP E----TPGTGALQRTPGAKA-----------APVLPSKAASAPASAPQPLNLQ--SKPVQAKDASG----HTASAPAKRS VAPPNREYAPAA---PPGRL-----------------------------------PSRKSLQ--DKVPETAEVQKAKVQT RLDKSGVQKAAEL--HQDRSAAKDGKKKNEMSAGEDESSSESDQD----------------------------------- QSAS-AVQNQGWKPARSLIEHVFVTDVTANLVTVTVKESPTSVGFFSLRPY----------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------- >ZEBRAFISH_CBX3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----MGKKQA---------------GKSKK-EVQE-I----EEFVVEKVMDQRVV-NGKVEFFLKWKGFTDADNTWEPEE NLDCPELIAAFLESQKGVVEKP-----EAVKRKSS--------------------------------------TDEPG-T EESKAKRKKE---------------------------------------------------------------------- --MSDKPR------------------------------------------------------------------------ ------------------------GFARNLEPERIIGATDSSGELMFLMKWKD--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SDEADLVPAREAN------------------------------------ ----------------TRCPQIVIAFYEERLTWHSCPEDEQQ----------------------------------