>Homo_sapiens_PPARGC1A -------------------------------------------------------------------------------- -------------------------------------------------MAWDMCNQDSESVWSDIECAALVG------- -EDQPLCPDLPELDLS--ELDVNDLDTDSFLGGLKWCSD-----------QSEIISNQYNN--EPSNIFEKIDEENEANL LAVLTETLDSLPVD------------------------------EDGLPSFDALTDGDVTTDNEASPSSMPDGTPP---- -------------------------------------------------------------------------------- ---PQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHAN---------------------------------------- ---------------HNHRIRTNPAIVKTENSWSNKAKS----------------------------------------- -------------------ICQQQKPQRRPCSELLKYLTT---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------NDDPP-HTKPTENRNSSRD------------------------------------------------------- ---------KCTSKKKSHTQSQSQ--------HLQAKPTTLSLPLTPESPNDPKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSES-- ------SGTQGNNSTK----------------------KGPEQSELYAQLSKSS-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------VLTGGHEERKT----KRPSLR------- -------------------------------------------------------------------------------- --------------------------------LFGDHDYCQSINS----------------------------------- --------KTEILINISQELQDSRQLENKDVSSD-WQGQICSSTDS-DQCYLRETLEASKQVSPCS------TRKQLQDQ EIRAELNKHFG------HPSQAVFDDEADKTGELRD-SDFSNEQFSKLPMFINS-------------------------- -------GLAMDGLF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DDSEDESDKLS------------------------------YPWDGTQSYSLFNV---SPSC S----------------------------------------------------------------SFNSPCRDSVSPPKS LFSQRP-------------------------------------------QRMRSR---SRSFS--------RHRSCSRSP YSRSRSRSPGSRSSSRSCYYYESSHYR-------------------------------HRTHRNSPLYVRSRSRSPYSRR P---------------------RYDSYEEYQHERLKREEYRREYE----------------------------KRESERA KQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDD----------------------------- -------GDSYGFI-------------------------------------------------TYRYTCDAFAALENGYT LRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDP------------------------------------------AS TKSKYDSLDFDSLLKEAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Pan_troglodytes_PPARGC1A -------------------------------------------------------------------------------- -------------------------------------------------MAWDMCNQDSESVWSDIECAALVG------- -EDQPLCPDLPELDLS--ELDVNDLDTDSFLGGLKWCSD-----------QSEIISNQYNN--EPSNIFEKIDEENEANL LAVLTETLDSLPVD------------------------------EDGLPSFDALTDGDVTTDNEASPSSMPDGTPP---- -------------------------------------------------------------------------------- ---PQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHAN---------------------------------------- ---------------HNHRIRTNPAIVKTENSWSNKAKS----------------------------------------- -------------------ICQQQKPQRRPCSELLKYLTT---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------NDDPP-HTKPTENRNSSRD------------------------------------------------------- ---------KCISKKKSHTQSQSQ--------HLQAKPTTLSLPLTPESPNDPKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSES-- ------SGTQGNNSTK----------------------KGPEQSELYAQLSKSS-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------VLTGGHEERKT----KRPSLR------- -------------------------------------------------------------------------------- --------------------------------LFGDHDYCQSINS----------------------------------- --------KTEILINISQELQDSRQLENKDVSSD-WQGQICSSTDS-DQCYLRETLEASKQVSPCS------TRKQLQDQ EIRAELNKHFG------HPSQAVFDDEADKTSELRD-SDFSNEQFSKLPMFINS-------------------------- -------GLAMDGLF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DDSEDESDKLS------------------------------YPWDGTQSYSLFNV---SPSC S----------------------------------------------------------------SFNSPCRDSVSPPKS LFSQRP-------------------------------------------QRMRSR---SRSFS--------RHRSCSRSP YSRSRSRSPGSRSSSRSCYYYESSHYR-------------------------------HRTHRNSPLYVRSRSRSPYSRR P---------------------RYDSYEEYQHERLKREEYRREYE----------------------------KRESERA KQRERQRQKAID-------------------------------------------------------------------- ---------SYGFI-------------------------------------------------TYRYTCDAFAALENGYT LRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDP------------------------------------------AS TKSKYDSLDFDSLLKEAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Pongo_abelii_PPARGC1A -------------------------------------------------------------------------------- -------------------------------------------------MAWDMCNQDSESVWSDIECAALVG------- -EDQPLCPDLPELDLS--ELDVNDLDTDSFLGGLKWCSD-----------QSEIISNQYNN--EPSNIFEKIDEENEANL LAVLTETLDSLPVD------------------------------EDGLPSFDALTDGDVTTDNEASPSSMPDGTPP---- -------------------------------------------------------------------------------- ---PQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHAN---------------------------------------- ---------------HNHRIRTNPAIVKTENSWSNKAKS----------------------------------------- -------------------ICQQQKPQRRPCSELLKYLTT---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------NDDPP-HTKPTENRNSSRD------------------------------------------------------- ---------KCTSKKKSHTQSQSQ--------HLQAKPTTLSLPLTPESPNDPKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSES-- ------SGTQGNNSTK----------------------KGPEQSELYAQLSKSS-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------VLTGGHEERKT----KRPSLR------- -------------------------------------------------------------------------------- --------------------------------LFGDHDYCQSINS----------------------------------- --------KTEILINISQELQDSRQLENKDVSSD-WQGQICSSTDS-DQCYLRETLEASKQVSPCS------TRKQLQDQ EIRAELNKHFG------HPSQAVFDDEADKTSELRD-SDFSNEQFSKLPMFINS-------------------------- -------GLAMDGLF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DDSEDESDKLS------------------------------YPWDGTQSYSLFNV---SPSC S----------------------------------------------------------------SFNSPCRDSVSPPKS LFSQRP-------------------------------------------QRMRSR---SRSFS--------RHRSCSRSP YSRSRSRSPGSRSSSRSCYYYESSHYR-------------------------------HRTHRNSPLYVRSRSRSPYSRR P---------------------RYDSYEEYQHERLKREEYRREYE----------------------------KRESERA KQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDD----------------------------- -------GDSYGFI-------------------------------------------------TYRYTCDAFAALENGYT LRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDP------------------------------------------AS TKSKYDSLDFDSLLKEAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Macaca_mulatta_PPARGC1A -------------------------------------------------------------------------------- -------------------------------------------------MAWDMCNQDSESVWSDIECAALVG------- -EDQPLCPDLPELDLS--ELDVNDLDTDSFLGGLKWCSD-----------QSEIISNQYNN--EPSNIFEKIDEENEANL LAVLTETLDSLPVD------------------------------EDGLPSFDALTDGDVTTDNEASPSSMPDGTPP---- -------------------------------------------------------------------------------- ---PQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHAN---------------------------------------- ---------------HNHRIRTNPAIVKTENSWSNKAKS----------------------------------------- -------------------ICQQQKPQRRPCSELLKYLTT---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------NDDPP-HTKPTENRNSSRD------------------------------------------------------- ---------KCTSKKKSHTQSQSQ--------HLQAKPTTLSLPLTPESPNDPKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKPKSSCKTVVPPPSKKPRYSES-- ------SGTQGNNSTK----------------------KGPEQSELYAQLSKST-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------VLTGGHEERKT----KRHSLR------- -------------------------------------------------------------------------------- --------------------------------LFGDHDYCQSINS----------------------------------- --------KTEILIHISQELQDSRQLENKDVSSD-WQGQICSSTDS-DQCYLRETSEASKQVSPCS------TRKQLQDQ EIRAELNKHFG------HPSQAVFDDEADKTSELRD-SDFSNEQFSKLPMFINS-------------------------- -------GLAMDGLF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DDSEDESDKLS------------------------------YPWDGTQSYSLFNV---SPSC S----------------------------------------------------------------SFNSPCRDSVSPPKS LFSQRP-------------------------------------------QRMRSR---SRSFS--------RHRSCSRSP YSRSRSRSPGSRSSSRSCYYYESSHYR-------------------------------HRTHRNSPLYVRSRSRSPYSRR P---------------------RYDSYEEYQHERLKREEYRREYE----------------------------KRESERA KQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDD----------------------------- -------GDSYGFI-------------------------------------------------TYRYTCDAFAALENGYT LRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDP------------------------------------------AS TKSKYDSLDFDSLLKEAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Canis_familiaris_PPARGC1A -------------------------------------------------------------------------------- -------------------------------------------------MAWDMCNQDS--VWSDIECAALVG------- -EDQPLCPDLPELDLS--ELDVNDLDTDSFLGGLKWCSD-----------QSEIISNQYNN--EPSNIFEKIDEENEANL LAVLTETLDSLPVD------------------------------EDGLPSFDALTDGDVTTENEASPSSVPDGTPP---- -------------------------------------------------------------------------------- ---PQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHAN---------------------------------------- ---------------HNHRIRTNPAVVKTENSWSNKAKS----------------------------------------- -------------------ICQQQKPQRRPCSELLKYLTT---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------NDDPP-HTKPTENRNSSRD------------------------------------------------------- ---------KCTSKKKSHTQSQSQ--------HLQAKPTTLSLPLTPESPNDPKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRTSPKLKSSCKTVVPPPSKKPRYSEP-- ------SGTQGNTSTK----------------------KGPEQSELYAQLSKTS-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------VLTSGHEERKA----KRPSLR------- -------------------------------------------------------------------------------- --------------------------------LFGDHDYCQSINS----------------------------------- --------KTEILINISQELQDSRQLEYKDASSD-WQGQICSSTDS-DQCYLRETSGAGKQVSPCS------TRKQLQDQ EIRAELNKHFG------HPSQAVFDDEADKTSELRN-SDFSNEQFSKLPMFINS-------------------------- -------GLAMDGLF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DDSEDESDKLN------------------------------YPWDGTQSYSLFDV---SPSC S----------------------------------------------------------------SFNSPCRDSVSPPKS LFAQRP-------------------------------------------QRMRSR---SRSFS--------RHRSCSRSP YSRSRSRSPGSRSSSRSCYHYESSHCR-------------------------------HRAHRNSPLCARSRSRSPYSRR P---------------------RYDSYEEYQHERLKREEYRREYE----------------------------KRESERA KQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDD----------------------------- -------GDSYGFI-------------------------------------------------TYRYTCDAFAALENGYT LRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDP------------------------------------------AS TKSKYDSLDFDSLLKEAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Felis_catus_PPARGC1A -------------------------------------------------------------------------------- -------------------------------------------------MAWDMCNQDS--VWSDIECAALVG------- -EDQPLCPDLPELDLS--ELDVNDLDTDSFLGGLKWCSD-----------QSEIISNQYNN--EPSNIFEKIDEENEANL LAVLTETLDSLPVD------------------------------EDGLPSFDALTDGDVTTENEASPSSMPDGTPP---- -------------------------------------------------------------------------------- ---PQEAEETSLLKKLLLAPANTQLSYNECSGLSTQNHAN---------------------------------------- ---------------HNHRIRTNPAVVKTENSWSNKARS----------------------------------------- -------------------ICQQQKPQRRPCSELLKYLTT---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------NDDPP-HIKPTENRNSSRD------------------------------------------------------- ---------KCTSKKKSHTQSQSQ--------HLQAKPTTLSLPLTPESPNDPKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRTSPKLKSSCKTVGPPPSKKPRYSEP-- ------PGTQGNNSTK----------------------KGPEQSELYAQLSKTS-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------VLTSGHEERKA----KRPSLR------- -------------------------------------------------------------------------------- --------------------------------LFGDHDYCQSINS----------------------------------- --------KTEILINISQELQDSRQLEYKDAPSD-WQGQICSSTDS-DQCYLRETPGAGKQVSPGS------TRKQLQDQ EIRAELNKHFG------HPSQAVFDDEADKTSELRD-SDFSNEQFSKLPMFINS-------------------------- -------GLAMDGLF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DDSEDESDKLN------------------------------YPWDGTQSYSLFDV---SPSC S----------------------------------------------------------------SFNSPCRDSVSPPKS LFSQRP-------------------------------------------QRMRSR---SRSFS--------RHRSCSRSP YSRSRSRSPGSRSSSRSCYYYESSHCR-------------------------------HRAHRNSPLCARSRSGSPYSRR P---------------------RYDSYEEYQHERLKREEYRKEYE----------------------------KRESERA KQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDD----------------------------- -------GDSYGFI-------------------------------------------------TYRYTCDAFAALENGYT LRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDP------------------------------------------AS TKSKYDSLDFDSLLKEAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Equus_caballus_PPARGC1A -------------------------------------------------------------------------------- -------------------------------------------------MAWDMCNQDS--VWSDIECAALVG------- -EDQPLCPDLPELDLS--ELDVNDLDTDGFLGGLKWCSD-----------QSEIISNQYNN--EPSNIFEKIDEENEANL LAVLTETLDSLPVD------------------------------EDGLPSFDALTDGDVTTENEASPSSMPDGTPP---- -------------------------------------------------------------------------------- ---PQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHAN---------------------------------------- ---------------HNHRIRTNPAVVKTENSWSNKAKS----------------------------------------- -------------------ICQQQKPQRRPCSELLKYLTT---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------NDDPP-HTKPTENRNSSRD------------------------------------------------------- ---------KCTSKKKSHTQSQSQ--------HLQAKPTTLSLPLTPESPNDPKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSEP-- ------SGTQGNNSTK----------------------KGPEQSELYAQLSKSS-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------VLTSGHEERKA----KRPSLR------- -------------------------------------------------------------------------------- --------------------------------LFGDHDYCQSINS----------------------------------- --------KTEILINISQELQDSRQLEYKDASSN-WQGQICSSTDS-DQCYLRETLEGSKQVSPCS------TRKQLQDQ EIRAELNKHFG------HPSRAVFDDEADKTSELRD-SDFSNEQFSKLPMFINS-------------------------- -------GLAMDGLF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DDSEDESDKLN------------------------------YPWDGTQSYSLFDV---SPSC S----------------------------------------------------------------SFNSPCRDSVSPPKS LFSQRP-------------------------------------------QRMRSR---SRSFS--------RHRSCSRSP YSRSRSRSPGSRSSSRSCYYHESSHCR-------------------------------HRTHRNSPLCARSRSRSPYSRR P---------------------RYDSYEEYQHERLKREEYRKEYE----------------------------KRESERA KQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDD----------------------------- -------GDSYGFI-------------------------------------------------TYRYTCDAFAALENGYT LRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDP------------------------------------------AS TKSKYDSLDFDSLLKEAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Loxodonta_africana_PPARGC1A -------------------------------------------------------------------------------- -------------------------------------------------MAWDMCNQDS--VWSDIECAALVG------- -EDQPLCPDLPELDLS--ELDVNDLDTDSFLGGLKWCSD-----------QSEIISNQYNN--EPSNIFEKIDEESEANL LAVLTETLDSLPVD------------------------------EDGLPSFDALTDGDVTTDNDASPSSMPDGTPP---- -------------------------------------------------------------------------------- ---PQEAEEPSLLKKLLLAPANTQLSYSECSGLSTQNHAN---------------------------------------- ---------------HNHRIRTNPAVVKTETSWSNKAKS----------------------------------------- -------------------ICQQQKPQRRPCSELLKYLTT---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------NDDPP-HTKPTENRNSHRD------------------------------------------------------- ---------KCTSKKKPHTQSQVS--------HLQAKPTTLSLPLTPESPNDPKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRTSPKLKSSCKTVVPLPSKKPRHSES-- ------SGTQGNNSTK----------------------KGPKQSELYAQLSKTS-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------VLTSGHEERKT----KRPSLR------- -------------------------------------------------------------------------------- --------------------------------LFGDHDYCQSINS----------------------------------- --------KSEILINISQELQDSRKLEYKDASSD-WQGQICSSTDS-DQCYLRETLEASKQVSPGS------TRKQLQDQ EIRAELNKHFG------HPSQAVFDDEANKTSELRD-SDFSNEQFSKLPMFINS-------------------------- -------GLAMDGMF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------EDSEDESDKLS------------------------------YPWDGTQSYSLFDV---SPSC S----------------------------------------------------------------SFNSPCRDSVSPPKS LFSQRP-------------------------------------------QRMCSR---SRSFS--------RHRSCSRSP YSRSRSRSPGSRSSSRSCHYCESSHCR-------------------------------HRTHRNPPLCGRSRSRSPCSRR P---------------------RYDSYEEYQHERLKREEYRKEYE----------------------------KRESERA KQRERQRQKAIEERRVIYVGKIGSDTTRTELRDRFEVFGEIEECTVNLRDD----------------------------- -------GDSYGFI-------------------------------------------------TYRYTCDAFAALENGYT LRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDP------------------------------------------AS AKSKYDSLDFDSLLKEAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Ornithorhynchus_anatinus_PPARGC1A -------------------------------------------------------------------------------- -------------------------------------------------MAWDMCNQDS--VWSDIECAALVG------- -EDQPLCPDLPELDLS--ELDVNDLDADSFLGGLKWYSD-----------QSEIISNQYSN--EPSNIFEKIDEENEANL LAVLTETLDSIPVD------------------------------EDGLPSFDALTDGDVTNENDSSPSSMPDGTPP---- -------------------------------------------------------------------------------- ---TQEAEEPSLLKKLLLAPANTQLSYNECCGLSTQNHAN---------------------------------------- ---------------PNHRIRTIPAVVKTENSWSNKAKS----------------------------------------- -------------------ICQQQKPQRRPCSELLKYLTT---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------NDDPP-QTKAAESRSSSQD------------------------------------------------------- ---------KCTSKKKPHLQPQTH--------HLQAKPTSLSLPLTPESPNDAKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KNIERTLSVELSGTAGLTPPTTPPHKVNQDSPFRTSPKPKSSCKTVVP-PSKKPRFSES-- ------SRTQGNNPNK----------------------KSPEQSELYAQLSKNS-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------VLSSGHEERKS----KRPSLR------- -------------------------------------------------------------------------------- --------------------------------LFGDHDYCQSLNA----------------------------------- --------KAEIRINVPQELQDSRQLEYKDSSSG-WQWQICTSADQ-DQCSTRETSQESKQGAPRN------NRKQLQDQ EIRAELNKHFG------HPSQAVFDDEADKTSELRD-SDFSNEQFSKLPMFINS-------------------------- -------GLAMDGLF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DDSEDENDKLC------------------------------YPWDGTQFYSLFDV---SPSC S----------------------------------------------------------------SFNSPCRDSVSPPKS LFSQRS-------------------------------------------QRILSR---SRSFS--------RHRSCSRSP YSRSRSRSPSSRSSSRSCYYYEPSHCR-------------------------------PRAPRRSPLHARSRSRSPFSRR P---------------------RYDSYEEYQHERLKREEYRKEYE----------------------------KRESERA KQRDRQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDD----------------------------- -------GDSYGFI-------------------------------------------------TYRYTCDAFAALENGYT LRRSNEPDFELYFCGRKQFFKSNYADLDSNSDDFDP------------------------------------------AS TKSKYDSMDFDSLLREAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Gallus_gallus_PPARGC1A -------------------------------------------------------------------------------- -------------------------------------------------MAWDMCNQDS--VWSDIECAALVG------- -EDQPLCPDLPELDLS--ELDVNDLDADSFLGGLKWYSD-----------QSEVISSQYSN--EPANIFEKIDEENEANL LAVLTETLDSIPVD------------------------------EDGLPSFDALTDGDVTNEHDASPSPMPDGTPP---- -------------------------------------------------------------------------------- ---PQEAEEPSLLKKLLLAPANTQLNYNECSGLSTQNHAN---------------------------------------- ---------------TNHRIRTSPVVVKTENSWSNKAKS----------------------------------------- -------------------ICQQQKPQRRPCSELLKYLTT---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------NDDPP-QTKPAENRNSSKE------------------------------------------------------- ---------KCTSKRKPHLQSQTN--------HLQAKPTSLSLPLTPESPNDPKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIEQTLSVELSGTAGLTPPTTPPHKANQDNPFRTSPKPKSSCKTVAP-PSKKPRYSES-- ------SGSQGNNPVK----------------------KGPEQTELYAQLSKTT-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------ALSSGHEERKT----KRPSLR------- -------------------------------------------------------------------------------- --------------------------------LFGDHDYCQSVNS----------------------------------- --------KSEIHIKISQELQDSRQLEFKDSSPG-WQCQICSSLEQ-DQYFKKETLQTSKQGSQGN------NRKQLQDQ EIRAELNKHFG------HPSQAVFDEEADKTGELRD-SDYSNEQFSKLPMFINS-------------------------- -------GLAMDGLF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DDSEDESDKLC------------------------------YPWDGTQAYSLFDV---SPSC S----------------------------------------------------------------SFNSPCRDSVSPPKS LFSQRS-------------------------------------------QRTRSR---SRSFP--------QRRSCSRSP YSRSRSRSPCSRSSSRSCHCYESSHCR-------------------------------HRAHRSSPSRARSRSRSPYSRR P---------------------RYDSYEEYQHERLKREEYRKEYE----------------------------KRESERA KQRERQRQKAIEERRVIYVGKIRPDTTRKDLRDRFEVFGEIEECTVNLRDD----------------------------- -------GDSYGFI-------------------------------------------------TYRYTCDAFAALENGYT LRRSNEPDFELYFCGRKQFCKSNYADLDSNSDDFDP------------------------------------------AS TKSKYDSMDFDSLLKEAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Anolis_carolinensis_PPARGC1A -------------------------------------------------------------------------------- -------------------------------------------------MAWDMCNQDS--VWSDIECAALVG------- -EDQPLCPDLPELDLS--ELDVNDLDADSFLGGLKWYSD-----------QSEIISNQYAN--ESSNIFEKIDEENEANL LAVLTETLDSIPVD------------------------------EDGLPSFDALTDGDVTNENDASPSPMPDGTPP---- -------------------------------------------------------------------------------- ---AQEAEEPSLLKKLLLAPANIQLNYNECSGLSTHNHAN---------------------------------------- ---------------ANHRIRTSPVVVKTENSWSNKTKS----------------------------------------- -------------------ICQPQKPQRRQCSELLKYLTT---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------NDDPP-QTKPTENRNSSRD------------------------------------------------------- ---------KCTSKKKVLLHSQMH--------HLQAKPMSLSLPLTPESPNDPKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIEQTLSVELSGTAGLTPPTTPPHKANQDNPFRTSPKPKSSCKTVMP-PSKKPRCNES-- ------SSSQGHNLGR----------------------KGPEQSELYAQLSKTT-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------VLSVSHEERKT----KRPGLR------- -------------------------------------------------------------------------------- --------------------------------LFGDHDYCQSANS----------------------------------- --------KTGIRINRSQEPQDSRQVDLNGGLPE-QWCHICSSFEQYNQYDKRETSQASKQDLQFN------NRKLLQDQ EIRAELNKHFG------HLSQAVFEEETTKISELRDNSNFSDEQFSKLPMFINS-------------------------- -------GLTMDGLF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DDSEDENDKLC------------------------------CSWDGTQAYSLFDL---SPSC S----------------------------------------------------------------SFNSPCGDSVSPPKS LLSQRF-------------------------------------------QRIRSR---SRSFP--------QHRSCSHSP YSRSRSRSPCSRFSSRSCYYYESSHCR-------------------------------PQAYRSSPLYSRSRSRSPYSHR P---------------------RYDSYEEYQHERLKREEYRKEYE----------------------------KRESERA KQRERQKQKAIEEQRVIYVGKIGPDTTRAELRDRFEVFGEIEECSVNLQDN----------------------------- -------GDNYGFI-------------------------------------------------TYRYTCDAFAALENGYT LRRTNEPDFELYFCGQKQFCKSNYADLDSNSDDFDP------------------------------------------AS TKSKYDSMDFDSLLKEAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Xenopus_tropicalis_PPARGC1A -------------------------------------------------------------------------------- -------------------------------------------------MAWDMCNQDS--VWSDIECAALVG------- -EDQPLCPDLPELDLS--ELDVNDLDADSFLGGLKWYSD-----------QSENISNQYSS--ESSNIFEKIDEENEENL LAVLTETLDSLPVD------------------------------EDGLPSFDALTDGDVTNEHDPSLSSMPDGTPP---- -------------------------------------------------------------------------------- ---TQEAEEPSLLKKLLLAPANAQLIYNECIGFTTQNHAS---------------------------------------- ---------------PSQRIRTNSAVVKTENSWSNKPKT----------------------------------------- -------------------ICHSQKPPRRPCSELLKYLTS---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------NDDPP-QTKSTESRNSRLD------------------------------------------------------- ---------KCSSKKKPYLQPQP---------HYQARATSLSLPLTPESPNDPKECPFIR-------------------- -------------------------------------------------------------------------------- -------------------KFSQDLLFVEFFFVIGLTPPTTPPHKANQENPFRTSPKLKS-CKSSVP-PAKKSRYIES-- ------SSIQVLYPAK----------------------KGPEQSELYAQLSKAT-------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------VVIG-QEEKKA----KRPSLR------- -------------------------------------------------------------------------------- --------------------------------LFGDHDYCQFMNS----------------------------------- --------KSEIHISLSQELQASRHLECKDPLPG-KELKVCSYTDQ-EQCQ-KDSLPVTMPSSQNS------HRKQLQDQ EIRAELNKHFG------HPTQAVYNDET-KISELVD-NKYSDEQLSRLPMFLTA-------------------------- -------GLEIDSLF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------DDSEDENDKLC------------------------------YTWDETQSYSLFDE---SPSC S----------------------------------------------------------------TFNSPSRYSVSPPTS LFSQR--------------------------------------------ICSRSR---SRSFS--------QFRSSSLSP YSRSRSRSPSSRSSSGSCCCYETDHCR-------------------------------EKT---SPMYARSRSRSPYGRR P---------------------RYDSYEEYQHERLKREEYRKEYE----------------------------KRESERA KQRERQRQKAIEEHRVIFVGKMRPNMSRAELRARFEVFGEIEECTVNLRDD----------------------------- -------GNCYGFI-------------------------------------------------TYRYTCDAFAALENGYT LRRSNEPDFEVCFCERKQVCKSNYADLDSNSDDFDP------------------------------------------AS TKSKYDSMDFDSLLKEAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Danio_rerio_PPARGC1A_a -------------------------------------------------------------------------------- -------------------------------------------------MAWDRCNQDS--VWRELECAALVG------- -EDQPLCPDLPELDLS--ELDVSDLDADSFLGGLKWYSD-----------QSEIISSQYGN--EASNLFEKIDEENEANL LAVLTETLDSIPVD------------------------------EDGLPSFEALADGDVTNASDQSCPSTPDGSPR---- -------------------------------------------------------------------------------- ---TPEPEEPSLLKKLLLAPANSQLSYNQYPGGKAQNHAAS--------------------------------------- ----------------NQRIRPAPAVAKTENPWNSKPRGA---------------------------------------- -------------------CP--NRSMRRPCTELLKYLTS---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------SDE-AFQTKAGEAKSTWTGCGKDRGGACISSCSS-----------------------------SSSPSSSSTSS FSSLSSCSSSTASKKKTSSASPSSQQQQLAVQAQRAKPTILPLPLTPESPNDHKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIERTLSVEICGTPGLTPPTTPPHKASQENPFKVSLKNKLSSCSPSALTSKRPRLSNGGS ---CPQP---TSGSIR----------------------KGPEQTELYAQLSKASSTMPQG-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------GLEDRRGKRPMPRVFGDHDYCQSTSTK------- -------------------------------------------------------------------------------- --------------------------------RDSTTPAAVVPGPTEGRHVECKDLNM---------------------- --------PTSTTTTSSLSSTPPSSSSLARQLQGLSPTPQEACPDTYAHVQHHDSSSKMTMDCSSG------GRKLLRDQ EIRDELNKHFG------KPQQAFYSGVVGEPRGKQP-IEDSDSGDEYPGLLGDY-------------------------- -------IHPGLPDF----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------EDLEVGRERLF------------------------------YLGEGSPLELLLEG---SPSS SP---------------------------------------------------------------SSSSFSWCSVSPPSS QLSP----------------------------QH------L----RWPRSISRSR---SRSSS--------HHRRRSLSR SPYSRSGSPSSRSPSWSPRNMDESTFT-------------------------------PRICG----NPQSQSHSLFGRR P---------------------RYDSYEEYQHERLKREEYRRDYE----------------------------KRECERA EQRERQRQKAIEERRVVYVGRLRADSTRTELKRRFEVFGEIEESTVNLRHD----------------------------- -------GDNFGFI-------------------------------------------------TYRYTCDALAALENGHT LRRSNEPHFELCLGGQKQYSKSNYTDLDSHSDDFDP------------------------------------------AS TKSKYDSMDFDSLLREAQYSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Takifugu_rubripes_PPARGC1A_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------KKIDEENEANL LAVLTETLDSIPVD------------------------------EDGLPSFEALADGDVTNASDRSCPSSPDGSPR---- -------------------------------------------------------------------------------- ---TPEPEEPSLLKKLLLAPANSQLSYNQYTGGQAQNHAAS--------------------------------------- ---------------SNHRIRPPPAVVKMESTWNGKARGG---------------------------------------- -------------------SSQQNRPVRRHCTELLKYLTA---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------TDDILLHAKNNSSTSSSSS------------------------------------------------------- ---------SSASKKKSAASSQQQ--------QQPPKPTTLPLPLTPESPNDHKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIERTLSVEIAGTPGLTPPTTPPHKASQENPFKASLKTKLSSCSSSASVCKRARLSESGP GALAPAPGASGGGPIR----------------------KGPEQTELYAQLSKASTALP---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------YCITLRAAGGGPEERRSTGNNRRAAPR------- -------------------------------------------------------------------------------- --------------------------------GYSDHDYCQASAK----------------------------------- --------KDSSADTVTMTTAEQQDLSSVDGKAAPARGFGSARTPSGDDEDQLQTCAIS--------------RKLLRDN QIRAELNKHFG------HPLQALYSQASQGREPPSH-----ANQAAAAPSLEGG-------------------------- -------FLPFHEEL----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------ELTQGRVSRFL------------------------------YPWEGTPLDLLFDCPPCSPSC SPP--------------------------------------------------------------SSCSPSRGSVSPPSS LLLSPS-------------------------------------------RPLCWTSAGSRSRS--------RSRSGSRSS SSHYRRRSLSSSPDRRPSSWSRHNQDS-------------------------------STFRSRTQKSPRPQPRSPLSRR P---------------------RYDSYEEYQHERLKREEYRRDYE----------------------------KRESERA EQREKQRQKAIEERRVVYVGRLRSDCTRTELKRRFEVFGEIEECAVNLRDD----------------------------- -------GDNFGFI-------------------------------------------------TYRYTCDAFAALENGHT LRRSNEPQFELCFGGQKQFCKSHYTDLDSHSDDFDP------------------------------------------AS TKSKYDSLDFDSLLREAQRSLRR--------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Oryzias_latipes_PPARGC1A_a -------------------------------------------------------------------------------- -------------------------------------------------MAWDRCNQDS--VWTELECAALVG------- -EDQPLCPDLPELDLS--ELDVSDLDADSFLGGLKWYSD-----------QSEIVSTQYGN--EASNLFEKIDEENEANL LAVLTETLDSIPVD------------------------------EDGLPSFEALADGDVTNASDRSCPSSPDGSPR---- -------------------------------------------------------------------------------- ---TPEPEEPSLLKKLLLAPANSQLSYNQYTGGKAQNHAAS--------------------------------------- ---------------SNHRIRPPPAVVKTESPWNGKARGG---------------------------------------- -------------------SSQQNRPVRRPCTELLKYLTA---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------TDDILLHTKGSEPKSAWGG------------------------------------------------------- ----------ASSKDKSGLALPSQQP--LQQHHQRAKPTTLPLPLTPESPNDYKGSPFEN-------------------- -------------------------------------------------------------------------------- -------------------KTIERTLSVEIAGTPGLTPPTTPPHKASQENPFKASLKTKLSSCSSSALTCKRSRLSELGA CVVALAPGASAGGPAR----------------------KGPEQTELYAQLSKASTALP---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------YTIAPYAVGGGLEEHRSPGNNKRACPR------- -------------------------------------------------------------------------------- --------------------------------GHSDHDYCQASARSK--------AAG---------------------- --------GTATVTTVEMTFTPRASDASMPSSGKQTLTQASPIPAFGAASMRDQP------QLCAT------SRKPLCDQ EIRAELNKHFG------HHPQAVHSQAP-QPAVAGE-NDYYSQKLLGSSYLHTG-------------------------- -------FLPFHDEI----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------ELGEGRDSRFV------------------------------YPWEGTPLDLLFDC---SPSS PS---------------------------------------------------------------CSPPS---SCSPSRG SLSPPSSLLLSP-------------------NRP------F----CWTTSGSRSR---SRSHS--------GSRSSSSRY RRRSLSSSPDRRPPSWSRHSTDLNVSR-------------------------------SRTHK----SPRPQSRSPLSRR P---------------------RYDSYEEYQHERLKREEYRLDYE----------------------------KREFERA EQREKQRQKAIEERRVVYVGRLRSDCTRTELKRRFEVFGEIEECAVNLRDD----------------------------- -------GDNFGFI-------------------------------------------------TYRYTCDAFAALENGHT LRRPNDPQFELCFGGQKQFCKSHYTDL----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Homo_sapiens_PPARGC1B -------------------------------------------------------------------------------- ----------------------------------------------MAGNDCGALLDEELSSFFLNYLADTQG-----GG SGEEQLYADFPELDLS--QLDASDFDSATCFGELQWCPE-----------NSETEPNQYSP--DDSELFQID-SENEA-L LAELTKTLDDIPED------------------------------DVGLAAFPALDGGDALSCTSASPAPSSAPPSP---- --------------------------------------------------------------------------APE-KP SAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAG---------------------------------------- ----------------LRSKSQRPCVKAD--STQDKKAP----------------------------------------- ----------------------MMQSQSRSCTELHKHLTS----AQCCLQ------DRGLQ----PPCLQSPRLPAK--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------E DKE-PGEDCPSPQPAPASPRDSLALGRADPG----------------------------------------------APV SQEDMQAMVQLIRYMHTYCLPQRKLP---PQTPEPLP-KACSNPSQQVRSRPWSRHHSKA-------------------- -------------------------------------------------------------------------------- --------------SWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPK STGPRPSLRPLRLEVKREVRRPARLQQ-----QEEEDEEEEEEEEEEEKEEEEE--WGRK-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------RPGRGLPWTKLGRKLESSVCPVRRSRR------- -------------------------------------------------------------------------------- --------------------------------LNPELGPWLTFADEP--LVPSEPQG-----ALPSLCLAPKAYD----- -VERELGSPTDEDSGQDQQLLRGPQIPALESPC-ESGCGDMDEDPSCPQLPPRDSPRCLMLALSQS---DPTFGKKSFEQ TLTVELCGTAG----LTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGL-------------------------- --SLKATPGAAHKLP----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------KKHPERSELLS--HLRHATA----------------QPASQAGQKRPFSCSFGDHDYCQVLR PEG--------------------------------------------------------------VLQRKVLRSWEPSGV HLEDWPQQGAPW-AEAQAPGREEDRSCDAGAPPK------D----STLLRDHEIRASLTKHFGLLETALEEEDLASCKSP EYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGV-----------------SPTCSDHCPYQSPPSKANRQLC S---------------------RSRSSSGSSPCHSWSPATRRNFR---CESRGPCSD----------------RTPS-IR HARKRREKAIG-EGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNR----------------------------- ------RGEKYGFI-------------------------------------------------TYRCSEHAALSLTKGAA LRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALP------------------------------------------AS GKSKYEAMDFDSLLKEAQQSLH---------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Pan_troglodytes_PPARGC1B -------------------------------------------------------------------------------- ----------------------------------------------MAGNDCGALLDEELSSFFLNYLADTQG-----GG SGEEQLYADFPELDLS--QLDASDFDSATCFGELQWCPE-----------NSETEPNQYSP--DDSELFQID-SENEA-L LAELTKTLDDIPED------------------------------DVGLAAFPALDGGDALSCTSASPAPSSAPPSP---- --------------------------------------------------------------------------APE-KP SAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAG---------------------------------------- ----------------LRSKSQRPCVKAD--STQDKKPP----------------------------------------- ----------------------VTQSQSRSCTELHKHLTS----AQCCLQ------DRGLQ----PPCLQSPRLPAK--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------E DKE-PGEDCPSPQPAPASPRDSLALGRADPG----------------------------------------------APV SQEDMQAMVQLIRYMHTYCLPQRKLP---PQTPEPLP-KACSNPSQQVRSRPWSRHHSKA-------------------- -------------------------------------------------------------------------------- --------------SWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPK STGPRPSLRPLRLEVKREVRRPARLQQ-----QEEEDEEEEEEEEEEEKEEEEE--WGRK-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------RPGRGLPWTKLGRKLESSVCPVRRSRR------- -------------------------------------------------------------------------------- --------------------------------LNPELGPWLTFADEP--LVPSEPQG-----ALPSLCLAPKAYD----- -VERELGSPTDEDSGQDQQLLRGPQIPALESPC-ESGCGDMDEDPSCPQLPPRDSARCLMLALSQS---DPTFGKKSFEQ TLTVELCGTAG----LTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGL-------------------------- --SLKATPGAAHKLP----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------KKHPERSELLS--HLRHATA----------------QPASQAGQKRPFSCSFGDHDYCQVLR PEG--------------------------------------------------------------VLQRKVLRSWEPSGV HLEDWPQQDAPR-AEAQAPGREEDRSCDAGAPPK------D----STLLRDHEIRASLTKHFGLLETALEEEDLASCKSP EYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDNEEEDSGV-----------------SPTCSDHCPYQSPPSKANRQLC S---------------------RSRSSSGSSPCHSWSPATRRNFR---CESRGPCSD----------------RTPS-IR HARKRREKAIG-EGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNR----------------------------- ------RGEKYGFI-------------------------------------------------TYRCSEHAALSLTKGAA LRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALP------------------------------------------AS GKSKYEAMDFDSLLKEAQQSLH---------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Pongo_abelii_PPARGC1B -------------------------------------------------------------------------------- ----------------------------------------------MAGNDCGALLDEELSSFFLNYLADTQG-----GG SGEEQLYADFPELDLS--QLDASDFDSATCFGELQWCPE-----------NSETEPNQYSP--DDSELFQID-SENEA-L LAELTKTLDDIPED------------------------------DVGLAAFPALDGGDALSCTSASPAPSSAPPSP---- --------------------------------------------------------------------------APE-KP SASAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAG---------------------------------------- ----------------LRSKSQRPCVKAD--STQDKKAP----------------------------------------- ----------------------MTQSQSRSCTELHKHLTS----AQCCLQ------DRGLQ----PPCLQSPRLPAK--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------E DKE-PGEDCPSPQPAPASPRDSLALGRADPG----------------------------------------------TPV SQEDMQAMVQLIRYMHTYCLPQRKLP---PQAPEPLP-KACSNPSQQVRSRPWSRHHSKA-------------------- -------------------------------------------------------------------------------- --------------SWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPK STGPRPSLRPLRLEVKGEVRRPARLQQ-----QEEEDEEEEEEEEEEEKEEEEE--WGRK-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------RPGRGLPWTKLGRKLESSVCPVRRSRR------- -------------------------------------------------------------------------------- --------------------------------LNPELGPWLTFADEP--LVPSEPQG-----ALPSLCLAPKAYD----- -VERELGSPTDEDSGQDQQLLRGPQIPALESPC-ESGCGDMDEDPSCPQLPPRDSPRCLMLALSQS---DPTFGKKSFEQ TLTVELCGTAG----LTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGL-------------------------- --SLKATPGAAHKLP----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------KKHPERSELLS--HLRHATA----------------QPASQAGQKRPFSCSFGDHDYCQVLR PEG--------------------------------------------------------------ILQRKVLRSWEPSGV HLEDWPQQGAPR-AEAQAPGREEDRSRDAGTPPK------D----SMLLRDHEIRASLTKHFGLLETALEEEDLASCKSP EYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDNEEEDSGV-----------------SPTCSDHCPYQSPPSKANRQLC S---------------------RSRSSSGSSPCHSWSPATRRNFR---CESRGPCSD----------------RTPS-IR HARKRREKAIG-EGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRSR----------------------------- -------GEKYGFI-------------------------------------------------TYRCSEHAALSLTKGAA LRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALP------------------------------------------AS GKSKYEAMDFDSLLKEAQQSLH---------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Mus_musculus_PPARGC1B -------------------------------------------------------------------------------- ----------------------------------------------MAGNDCGALLDEELSSFFLNYLSDTQG-----GD SGEEQLCADLPELDLS--QLDASDFDSATCFGELQWCPE-----------TSETEPSQYSP--DDSELFQID-SENEA-L LAALTKTLDDIPED------------------------------DVGLAAFPELDEGDTPSCTPASPAPLSAPPSP---- --------------------------------------------------------------------------TLE-RL LSPASDVDELSLLQKLLLATSSPTASSDALKDGATWSQTS---------------------------------------- ----------------LSSRSQRPCVKVD--GTQDKKTP----------------------------------------- ----------------------TLRAQSRPCTELHKHLTS----VLPCPR------VKACS----PTPHPSPRLLSK--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------E EEEEVGEDCPSPWPTPASPQDSLAQDTASPDS---------------------------------------------AQP PEEDVRAMVQLIRYMHTYCLPQRKLP---QRAPEPIP-QACSSLSRQV--QPRSRHPPKA-------------------- -------------------------------------------------------------------------------- --------------FWTEFSILRELLAQDILCDVSKPYRLAIPVYASLTPQSRPRPPKDSQASPAHSAMAEEVRITASPK STGPRPSLRPLRLEVKRDVNKPTRQKR------EEDEEEEEEEEEEEEEKEEEEEEWGRK-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------RPGRGLPWTKLGRKMDSSVCPVRRSRR------- -------------------------------------------------------------------------------- --------------------------------LNPELGPWLTFTDEP--------LG-----ALPSMCLDTETHN----- -LEEDLGSLTD--SSQGRQLPQGSQIPALESPC-ESGCGDTDEDPSCPQPTSRDSSRCLMLALSQS----DSLGKKSFEE SLTVELCGTAG----LTPPTTPPYKPMEEDPFKPDTKLSPGQDTAPSLPSPEAL-------------------------- --PLTATPGASHKLP----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------KRHPERSELLS--HLQHATT----------------QPVSQAGQKRPFSCSFGDHDYCQVLR PEA--------------------------------------------------------------ALQRKVLRSWEPIGV HLEDLAQQGAPLPTETKAPRREANQNCDP--THK------D----SMQLRDHEIRASLTKHFGLLETALEGEDLASCKSP EYDTVFEDSSSSSGESSFLLEEEEEEEEGGEEDDEGEDSGV-----------------SPPCSDHCPYQSPPSKASRQLC S---------------------RSRSSSGSSSCSSWSPATRKNFR---RESRGPCSD----------------GTPS-VR HARKRREKAIG-EGRVVYIRNLSSDMSSRELKKRFEVFGEIVECQVLTRSK----------------------------- ------RGQKHGFI-------------------------------------------------TFRCSEHAALSVRNGAT LRKRNEPSFHLSYGGLRHFRWPRYTDYDPTSEESLP------------------------------------------SS GKSKYEAMDFDSLLKEAQQSLH---------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Rattus_norvegicus_PPARGC1B -------------------------------------------------------------------------------- ----------------------------------------------MAGNDCGALLDEELSSFFLNYLSDTQG-----GE SGEEQLCADLPELDLS--QLDASDFDSATCFGELQWCPE-----------TSETEPSQYSP--DDSEFFQID-SENEA-L LAALTKTLDDIPED------------------------------DVGLAAFPGLDEGDTPSCTPASPAPLSVPPSP---- --------------------------------------------------------------------------ALE-RL LSPVSEVDELSLLQKLLLATSSPTASSDALKDGATWSQTS---------------------------------------- ----------------LSSRSQRPCVKVD--GTQDKKTP----------------------------------------- ----------------------MLRSQSRPCTELHKHLTS----VLPCPR------GKACS----PPPHPSPQLLSK--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------E DEE-VGEDCPSPWPAPASPQDSLGQDTANPNS---------------------------------------------AQV PKDDVRAMVQLIRYMHTYCLPQRKLP---QRASEPIP-QSCSSPLRKV--PPRSRQTPKA-------------------- -------------------------------------------------------------------------------- --------------FWTEFSILRELLAQDILCDVSKPYRLATPVYASLTPQSRTRPPKDSQASPAHSAMAEEVRITASPK STGPRPSLRPLRLEVKRDVNKPARQKR------EEDEEEEEEEEEEEE-KEDEEEEWGRK-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------RPGRGLPWTKLGRKMDSSVCPVRRSRR------- -------------------------------------------------------------------------------- --------------------------------LNPELGPWLTFTDEP--------LG-----ALPSMCLATETHD----- -LEEELGGLTD--SSQGQQLPLGSQIPTLESPC-ESGCGDTDEDPSCPRPPSRDSPRCLMLALSQS----DPLGKKSFEE SLTVELCGTAG----LTPPTTPPYKPMEEDPFKQDTKHSPGQDTAPSLPSPETL-------------------------- --QLTATPGASHKLP----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------KRHPERSELLS--HLQHATT----------------QPVSQAGQKRPFSCSFGDHDYCQVIR PEA--------------------------------------------------------------ALQRKVLRSWEPIKV HLEDLAHQGATLPVETKTPRREADQNCDP--TPK------D----SMQLRDHEIRASLTKHFGLLETALEEEDLASCKSP EYDTVFEDSSSSSGESSFLLEEEEEE--GGEEDDEGEDSGV-----------------SPPCSDHCPYQSPPSKASRQLC S---------------------RSRSSSGSSSCSSWSPATRKNFR---LESRGPCSD----------------GTPS-AR HAKKRREKAIG-EGRVVYIRNLSGDMSSRELKKRFEVFGEIVECQVLRRSK----------------------------- ------RGQKHGFI-------------------------------------------------TFRCSEHAALSVRNGAT LRKRNEPSFHLSYGGLRHFRWPRYTDYDPTSEESLP------------------------------------------SS GKSKYEAMDFDSLLKEAQQSLH---------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Canis_familiaris_PPARGC1B -------------------------------------------------------------------------------- ----------------------------------------------MAGNDCGALLDEELSSFFLNYLADAQS-----GV SGEEQLCADFPELDLS--QLDASDFDSATCFGELQWCPE-----------NSETEPSQYSP--DDSELFQITDSENEA-L LAALTKTLDDIPED------------------------------DVGLAAFPALDGGDAPSCTSASPAPSSSPPSPSP-- --------------------------------------------------------------------------SLE-RP QPPAPEVDDLSLLQKLLLATSYPASSSDTQKEGTTWRQAG---------------------------------------- ----------------LRSRNQRPCVKMD--STQDKKAP----------------------------------------- ----------------------TVQSQGRSCTELHKHLTS----VPSCPQTKARSPDRGLQ----PPPALSPPLPAK--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------E DEE-ASEDCPSPQPAPALPQDSPTPGRAGPG----------------------------------------------TQV SREDMQAMVQLIRYMHTYCLPQRKLP---PQASEPAP-QPCSSPSKQVKPRPRSQHPSKG-------------------- -------------------------------------------------------------------------------- --------------SWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRPRPRPPKDSQASPGHPSPVEEVRITASPR STGPRPSLRPLRLDVKGHTGRTARLQR----EEEEEEEDEEEE-EDEKDEEEEEEEWGRK-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------RPGRGLPWTKLGRKLESSVCPVRRSRR------- -------------------------------------------------------------------------------- --------------------------------LNPELGPWLAFSDES--LVPVEPQG-----TLPSLRLAPEAYD----- -VEGALGSPTDEDSGQDQQLPRGPQIPALESPC-ESGCGDTDEDPSCPRLPSRDSPRCLMLALSQS---DTPFGRKSFEQ TLTVELCGTA----GLTPPTTPPYKPTEEDPFKPDIKHSPGKDRALSLPSLEGL-------------------------- --QLGPTTAAAPKLP----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------KKHPERSELLS--HLRHATA----------------QPASQTGQKRPFSCSFGDHDYCQVLK PEG--------------------------------------------------------------ALQRKVLRSWEPSGV HLEDCHQQGAPR-AEVQASAREEDRSCDSGGPAK------D----SVPLRDHEIRASLTKHFGLLETALEDEDLASCKSP EYDTVFEDSSSSSGESSFLLEEEEEEE------DEEEDSGV-----------------SPPRSDHCPYQSPPSKASRQLC S---------------------RSRSSSGSSSCRSRSPATRRTFR---CESRGPCSD----------------RTPS-VR HARKRREKAIG-EGRVVYVRNLSSDMSSRELKRRFEVFGEIVECQVLTRSK----------------------------- ------RGEKYGFI-------------------------------------------------TYRCSEHAALSLRNGAA LRKRHEPSFQLSYGGLQHFCWPRHTDYDSNSEEALP------------------------------------------AS VKTKYEAMDFDSLLKEAQQSLH---------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Felis_catus_PPARGC1B -------------------------------------------------------------------------------- ----------------------------------------------MR----RVICWTRIHVMFAGNTLLRKG-----GG SGEEQLCADFPELDLS--QLDASDFDSATCFGELQWCPE-----------SSETEPSQYSP--DDSELFQIIDSENEA-L LAALTKTLDDIPED------------------------------DVGLAAFPALDGGDAPSCTSASPAPSSAPPSPSP-- --------------------------------------------------------------------------SLE-RP QAPAPEVDELSLLQKLLLATSHPSSSSDTQKEGATWRQAG---------------------------------------- ----------------LRSKSQRPCVKMD--GTQDKKVP----------------------------------------- ----------------------TVQSQSRSCTELHRHLTS----VPSCPQTKARSPDRGLQ----PPPALSPQLPAK--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------E EEE-PGEDCPSPQPAPALPQDSPAPGRARPG----------------------------------------------TQV SREDMHAVVQLIRYMHTYCLPQRKLP---PQAPEPAP-QPCSSPSKQVKPQPRSQHPSKA-------------------- -------------------------------------------------------------------------------- --------------SWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRPRPRPPRDSQASPGHPSPVEEVRITASPR STGPRPSLRPLRLEVKGRAGRSARLQQQ-QEEEDEEEDEDEEE-EEEKEEEEEEEEWGRK-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------RPGRGLPWTKLGRKPESSVCPVRRSRR------- -------------------------------------------------------------------------------- --------------------------------LNPELGPWLTFSDES--LVPAEPQG-----ALSSLHLAPEAYD----- -MEGALGSPTDEDSGQDQQLPRGPQIPALESPC-ESGCGDTDEDPSCPRLPSRDSPRCLMLALSQS---DPPFGKKSFEQ TLTVELCGTA----GLTPPTTPPYKPTEEDPFKPDIKHSPGKDRAPSLPSLEGL-------------------------- --QLEAAAGAAHKLP----------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------KKHPERSELLS--HLRHATA----------------QPASQTGQKRPFSCSFGDHDYCQVLK PEG--------------------------------------------------------------ALQRKVLRSWEPSGV HLEDWPQQGALQ-AEVQASNREEDRSRDASAPAK------D----SVLLRDHEIRASLTKHFGLLESALEDEDLASCKSP EYDTVFEDSSSSSGESSFLLEEEEEEEE----DDEEEDSGV-----------------SPPCSDHCPYQSPPSKAGRQLC S---------------------RSRSSSCSSSCRSRSPAIRRTFR---CESRGPCSD----------------GTPS-VR HARKRREKAIG-EGRVVYVRNLSSDMSSRELKRRFEVFGEIVECQVLTRNN----------------------------- ------RGEKYGFI-------------------------------------------------TYRCSEHAALSLRNGAA LRKRNEPSFQLSYGGLQHFCWPRHTDYDSNSEETLP------------------------------------------AS VKNKYEAMDFDSLLKEAQQSLH---------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------ >Bos_taurus_PPARGC1B -------------------------------------------------------------------------------- -------------------------------------------------AKGSDCQYPKLSSDPPPFYLSPQG-----GG SGEEQLCADFPELDLS--QLDANDFDSATCFEELQWCPE-----------NSETDPSEYSP--DDLELFQIIDSENEA-L LAALTKTLDDMPED------------------------------VVSLAAFPALDDGDTPSCASASPIPSSAPPSP---- --------------------------------------------------------------------------SLE-GP PASAPEVDELSLLQKLLLATSYPTSASDSQKEGTAWRQAG---------------------------------------- ----------------LRSRNQRPCVKMD--GPQDRKAP----------------------------------------- ----------------------TPHPQSRSCTELHKHLTS----APSCPRAKALSPDRALQ----PPPSLSPRLPTK--- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------E DEE-AGEDCPSPQLAPASPGDSPALGRTDPS----------------------------------------------AQV SQEDMQAMVQLIRYMHTYCLPQRKLP---TQAPEPAP-QPSSSPAKQVRPRPRSQHPSKA-------------------- -------------------------------------------------------------------------------- --------------AWTEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRPR---PKDSQASAGHPGLVEEVRVSPSSK SSGPRPSLRPLRLQVKGHVSRSARLQP-------EEEEEEEEEEEEEEKEEEDEEEWGRK-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------RPGRGLPWTKLGRKPESSVCPVRRSRR------- -------------------------------------------------------------------------------- --------------------------------LNPELGPWLTFTDEP--MVPAEPQG-----PLPSR-LAPEAYD----- -VEGEPGSPTDEDSGQDQLLLRGPQIPALESPC-ESGCGDTDEDPSCLRLSSRDSPRCLMLALSQSPTGDPPFGKKSFEQ TLAVELCGTAAWV-GLTPPTTPPYKPTEEDPFKPDIKHSPGKDRAP---TPEGP-------------------------- --QLGATAEAAHKLP----------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------