>Homo_sapiens_POU1F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MSC-QAFTSADTFIP LN-----SDASATLPLI-----------------------MHHS-AAECLPVSNHATNVMSTVPSILSLIQT-------- -------------------------------------------------------------------------------- ---------------------------------------------------------------PKCLCTHFSVTT----- --------------------LGNTATGLHYSVPSCHYGNQ--------------PSTYGVMA------------------ -----------------------------------------------------------------------GSLTPCLYK FPDHTLS---------------------------------------------------------------HGFPPIHQPL LAEDP-----TAADFKQELRRK---------------------------------------------------------- ----------------SKLVEEPIDMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGS---EFSQTTIC---- --------------------------------RFENLQLSFKNACKLKAILSKWLEE------------------AEQVG ALYNEKVGANERKRKRRTTISIAAKDALERHFGE-QNKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSL FS-ISKEHLECR-------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Macaca_mulatta_POU1F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MSC-QAFTSADTFIP LN-----SDASATLPLI-----------------------MHHS-AAECLPVSNHATNVMSTVPSILSLIQT-------- -------------------------------------------------------------------------------- ---------------------------------------------------------------PKCLCTHFLVTT----- --------------------LGNTATGLHYSVPSCHYGNQ--------------PSTYGVMA------------------ -----------------------------------------------------------------------GSLTPCLYK FPDHTLS---------------------------------------------------------------HGFPPIHQPL LAEDP-----TAADFKQELRRK---------------------------------------------------------- ----------------SKLVEEPIDMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGS---EFSQTTIC---- --------------------------------RFENLQLSFKNACKLKAILSKWLEE------------------AEQVG ALYNEKVGANERKRKRRTTISIAAKDALERHFGE-QNKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSL FS-ISKEHLECR-------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Mus_musculus_POU1F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MSC-QSFTSADTFIT LN-----SDASAALPLR-----------------------MHHS-AAECLPASNHATNVMSTVPSILSLIQT-------- -------------------------------------------------------------------------------- ---------------------------------------------------------------PTCLHTYFSMTT----- --------------------MGNTATGLHYSVPSCHYGNQ--------------PSTYGVMA------------------ -----------------------------------------------------------------------GSLTPCLYK FPDHTLS---------------------------------------------------------------HGFPPLHQPL LAEDP-----AASEFKQELRRK---------------------------------------------------------- ----------------SKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGS---EFSQTTIC---- --------------------------------RFENLQLSFKNACKLKAILSKWLEE------------------AEQVG ALYNEKVGANERKRKRRTTISVAAKDALERHFGE-HSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSL FS-ISKEHLECR-------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Ornithorhynchus_anatinus_POU1F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MSC-QPFTSADTFVP LN-----SDPSAALPLI-----------------------MHHS-AAECLPVSNHTTNVVSTVSFVLPVVQT-------- -------------------------------------------------------------------------------- ----------------------------------------------------------------KCSHVHFSLET----- --------------------LGN-ATGLHYSVPSCHYGSQ--------------QSTYGMMTGIKPTTSEMLSASLSQGR MLQTCSMSHPSVVNGVSALQGE-------------------------------------------PYYFLAGSLTPCLYK FPDHAL---------------------------------------------------------------GHGFPPMHQSL LGEDP-----LALDFKHEFRRK---------------------------------------------------------- ----------------SKSVEEPVDMDSPEIRELEKFANEFKLRRIKLGYTQTNVGEALAAVHGS---EFSQTTIC---- --------------------------------RFENLQLSFKNACKLKSILSKWLDE------------------AEQVG ALYNEKVGANERKRKRRTTISIAAKEALERHFGE-QSKPSSQEIMRMADGLNLEKEVVRVWFCNRRQREKRVKTSLHQNT FTSVTKEHHECR-------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Gallus_gallus_POU1F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MTC-QAFASSDNFVP LN-----SDSSPSLPLI-----------------------MHHS-AGECLPVSNHATNVVSTVPSVLSLIQT-------- -------------------------------------------------------------------------------- ---------------------------------------------------------------PKCSHLHFAMMT----- --------------------SGNVSAGLHYSVPSCHYGNQ--------------ASTYGVMAGIKPATPEMLSASLSQSR ILQTCSMPHPNVVNGVSTLQS---------------------------------------------------SLTPCLYK FPEHALSASSCAL--------------------------------------------------------GHSFTPMHQTL LSDDP-----TASDFKQEFRRK---------------------------------------------------------- ----------------SKSVEEPVDMDSPEIRELEKFANEFKLRRIKLGYTQTNVGEALAAVHGS---EFSQTTIC---- --------------------------------RFENLQLSFKNACKLKSILSKWLEE------------------AEQVG ALYNEKVGVNERKRKRRTTISISAKEALERHFGE-QSKPSSQEIMRMAEGLNLEKEVVRVWFCNRRQREKRVKTSLHQNA FSSIIKEHHECR-------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Danio_rerio_POU1F1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MSC-QAFSTSDSFSG LG-----GDTGAALPLL-----------------------MHHSAAADCHNTN-----ICSTVPSGLPLVQS-------- -------------------------------------------------------------------------------- ---------------------------------------------------------------SKRSHMHLSTSA----- --------------------LGNASASLHYPMPPCHYSNQ--------------QTTYGMMAAQEMLSASISQTRILQTC SVPHANMVNGANS--------------------------------------------------------LQGALAPRLYK FPEHSLAGGSCAL--------------------------------------------------------SHGFAPLPQTL LTDEP-----ILGDIKQELRRK---------------------------------------------------------- ----------------SRTLDETPDMDSPQIRELEKFANDFKLRRIKLGYTQTNVGEALAAVHGS---EFSQTTIC---- --------------------------------RFENLQLSFKNACKLKSILAKWLEE------------------AEQAG ALFNEKMGLHERKRKRRTTISLGAKEALERSFVE-KSKPSSQEIVRMAEGLHLEKEVVRVWFCNRRQREKRVKTSLHHSS FMTKDCRA------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Homo_sapiens_POU2F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------MADGGAASQDESSAAAAAAADSR MNNPSETSKPS--MES-----------------------GDGNTGTQT--NGLDFQKQPVPVGGAISTAQAQAFLGHLHQ VQLAGTSLQAAAQSLNVQSKSN--EESGD--------------------------------------------------S QQPSQPSQQP-SVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISAS---- ---------------------AATPMTQIPLSQPIQIAQ-DLQQLQQLQQQNLNLQQFVLVHP----TTNLQPAQFIISQ ------------------------TPQG------------------------------------------QQGLLQAQNL LTQ--------------------------------------------------------------------LPQQSQANL LQSQPSITLTSQPATPTRTIAAT--------------------------------------------------------- -----PIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLND------AENLSSDSSLSSPSALN SP--GIEGLS-RRRKKRTSIETNIRVALEKSFLE-NQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSG-- -GTSSSPIKAIFPSPT-SLVATTPSLVTS---------------SAATTLTVSPVLPLTS-------------------A AVTNLSVTGTSDTTSNN-TATVISTAPPASSAVTSPSLSPSPS------------ASASTS------------------- --------EASSASETSTTQTTSTP------------LSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAA AG-------------------------------LNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNST--------- -------------------LATIQALASGGSLPITSLDATGNLVFAN-----AGGAPNIVTAPLFLNPQNLSLLTSNPVS LVSAAAAS-AGNSAPVASLHATSTSAESIQNSLFTVASASGAASTTTTASKAQ------------------- >Macaca_mulatta_POU2F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MLDCSDYILDSR MNNPSETSKPS--MES-----------------------GDGNTGTQT--NGLDFQKQPVPVGGAISTAQAQAFLGHLHQ VQLAGTSLQAAAQSLNVQSKSN--EDSGD--------------------------------------------------S QQPSQPSQQP-SVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISAS---- ---------------------AATPMTQIPLSQPIQIAQ-DLQQLQQLQQQNLNLQQFVLVHP----TTNLQPAQFIISQ ------------------------TPQG------------------------------------------QQGLLQAQNL LTQ--------------------------------------------------------------------LPQQSQANL LQSQPSITLTSQPATPTRTIAAT--------------------------------------------------------- -----PIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLND------AENLSSDSSLSSPSALN SP--GIEGLS-RRRKKRTSIETNIRVALEKSFLE-NQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSG-- -GTSSSPIKAIFPSPT-SLVATTPSLVTS---------------SAATTLTVSPVLPLTS-------------------A AVTNLSVTGTSDTTSNN-TATVISTAPPASSAVTSPSLSPSPS------------ASASTS------------------- --------EASSASETSTTQTTSTP------------LSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAA AG-------------------------------LNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNST--------- -------------------LATIQALASGGSLPITSLDATGNLVFAN-----AGGAPNIVTAPLFLNPQNLSLLTSNPVS LVSAAAAS-AGNSAPVASLHATSTSAESIQNSLFTVASASGAASTTTTASKAQ------------------- >Gallus_gallus_POU2F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------MASWHINSR MNNPSETSKPS--MES-----------------------GDGNTGTQT--NGLDFQKQPVPVGGPISTAQAQAFLGHLHQ VQLAGTSLQAAAQSLNVQSKSN--EESGD--------------------------------------------------S QQPSQPSQQP-SVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQ--QAQAQLLAAAVQ-HSASQQHSAAGATISAS---- ---------------------AATPMTQIPLSQPIQIAQ-DLQHLQQLQQQNLNLQQFVLVHP----TTNLQPAQFIISQ ------------------------TPQG------------------------------------------QQGLLQAQNL LTQ--------------------------------------------------------------------LPQQSQANL LQSQPSITLASQPATPTRTIAAT--------------------------------------------------------- -----PIQPLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLND------AENLSSDSTLSSPSALN SPGQGIEGVN-RRRKKRTSIETNIRVALEKSFLE-NQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSG-- -GTSSSPIKAIFPCPT-SLVATTPSLVTS---------------SAATTLTVNPVLPLTS-------------------P AVTSLSVTGTTETTSNN-TATVISTAPPASSAVTSPSLSPSPS------------ASASIS------------------- --------EASSASETSTTQTTSTP------------LSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAA AG-------------------------------LNPGLMASSQFAAGGALLSLNPGTLGGALSPALMSNST--------- -------------------LATIQALASSGSLPITSLDASGNLVFAN-----AGGTPNIVTAPLFLNPQNLSLLTSNPVS LVSAAAAS-AGASGPVASLHATSTSAESIQNSLLTVASASGATSTTTTASKAQ------------------- >Anolis_carolinensis_POU2F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------MADGGAASQDESSAASAVAAADSR MNTPSETSKPVK-MES-----------------------GDGDTGTQT--NGLDFQKQTVPAAGAIST--AQAFLGHLHQ VHLPGSSLQAAAQSLNIQSKSN--EESGE--------------------------------------------------S QQPSQPSQQP-SLQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQ--QAQAQLLAAAVQ-HSASQQHNAAGATISAS---- ---------------------AATPMTQIPLSQPIQIAQ-DLQHLQQLQQQNLNLQQFVLVHP----TTNLQPAQFIISQ ------------------------TPQG------------------------------------------QQGLLQAQNL LTQ--------------------------------------------------------------------LPQQSQANL LQSQPSITFTSQPATPTRTIAAT--------------------------------------------------------- -----PIQPLPQNQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLND------AENLSSDSALSSPSALN SP--GAEGLN-RRRKKRTSIETNIRVALEKSFLE-NQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSG-- -GTSSSPIKAMFSCPT-SLVATTPSLVTS---------------SAATTLTVNPVLPLTS-------------------A AVTSLAVTGTTETIPNN-TATVISTAPPASSAVTSPSLSPSP--------------SASTS------------------- --------EASSASETSTTQTTSTP------------LSSAVGTSQVMVTASGLQTAAAAALQGVAQLPANASLAAMAAA AG-------------------------------LSPNLMASSQFAAGGALLSLNPATLGGALSPALMSNST--------- -------------------LATIQALASGGSLPITSLDATGNFVFAN-----AGGTPNIVTAPLFLNPQNLSLLTSNPVS LVSAAAAS-AGASGPVASLHATSTSAESIQNSLFTVASASGAASTTTTASKAQ------------------- >Danio_rerio_POU2F1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------MADGG AASQDESS----------------------------------GPGAQT--NGLDFQRQTVQTTSAITNAHAQALLQQ--- -------------------------------------------------------------------------------- -------------------------------LTLTPAQQQLLLQ--QAQAQLLAAAVQ-HSAGQQSSTTGASISAS---- ---------------------AATPITQIPLSQPIQITP--QLLQQQQQQQNLNLQQFVLVQPGHPIATQLQPAQFIISQ ------------------------TPQG------------------------------------------QQSLLQAQNL LTQ--------------------------------------------------------------------LPQ-SQANL LQTQPSITLATQPATPTRTIAAT--------------------------------------------------------- -----PIQSLAHTQTTPKHMDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLND---AVCAENQTSDQALSSPSSLG SPGLGMEGLN-RRRKKRTSIETNIRVALEKSFLEQNQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPNNG-- -SAASTPIKAIFSPTT-TLVPSTASLITS---------------NTPTTMTVNPVLPLTS-------------------T SVSGISFTGTTLGSAINNTASVISTAPAATTASSSPSLSPSPT------------AVQTSSS------------------ -------EQASAQETLTAVSQAPSS------------LASTLGTGQVMVAAP----SLSAALQGAAQLPTSASIAAMAAA AG-------------------------------LNPGLMASSQFAPGGALLSLAPGGLGSALSPALMSNST--------- -------------------LATIQALASSGTLPITSLDGSGNLLFANTS---AGSTPNLVTAPLFLNPQNLSLLASNPVS LVSAGGAAGAAGA---LNLHFTAD-----AHQSAVTTAT-MPASTITTASKAQ------------------- >Ciona_savignyi_POU2F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------LERWLMDANNVLRESKDG------ ------HSVVIPPQTN-----LDPHTMSRKRKKRTSIDAKKRTTLDRRFIMNPKPSSEELQSIAEECDMEKEVVRVWFCN RRQ---------------------KEKR-------------------------------------------ISMHEQQ-- --------------------------------------------------------------------------QELSSP DSPEHISAPTTSYSVPWKFTEAE--------------------------------------------------------- ---CEP-STSTVLRRPTP--QNSNIELNP-----SATVKSFPHNRIKQ---ESQKMATLPAVFG---------------- ---------------------------------------------------------------------HGVLSNPNQTP IL-------LSAAAAKSKGIQQAVSLHDHK----LGPSPSGPNHLFQ-------------------------------LN -KMDSMAFNN-----RVQPNHGQSQSK-----------------------TNNTSLPLPTT------------------T VLNSLLN-----------------------IGSTSFAMNNSHH------------------------------------- --------TMPSMVNSCTNSNFTLD--------------SKPGAAS---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Drosophila_melanogaster_POU2F1 -------------------------------------------------------------------------------- ------------------------------------MPLLLATTLANNSHHQHLSTTATETAAAAATAKAAATAAAAATA TMLLTSPTAATHCLAAATSAAGVNVQITGQGVSATLNDDQLQLPANYAANVGHLNGFNPKDNCPPVPPTSERAFEGLLRL PQIQVKQEFMESPPERPSCHPMNHQQAPANSALATSCRGKTILNPWYLRPADGIGYHNYNSNNNNSGSGEINKDVSQQMT SACGGSDGQTCLPVSY-----------------------FGMETLASVKQRQKSLPDFLIPLHEIMFQQQHHYQQRTMGT LINSLPPGLVGYPPQKTETFKSLTPPKALQHHQNNQNHQIPQNHTGDHSFVRHFHERDRLIREHQLKHQQLRDVEEVLQE QEQDEEQEHETLRKPHVVPSELEHNHHWHGVVCDANGHATRLLHIAPPRAGPTPLPTHQQPPVGEVLPPNSTSFSTIVDP PKEPSIYEQPAPNGRHCRPANKVMRHMSNSPTPPSPLRSLSDCGKSFEEEELELGENCEMPQNLSSKRQARELDSELENE VLDLAPPPKRLAEEQEEEKVASVNPPQPVAFA--------------------------PEEMHQALQLQLHSYIEMVRQL APEAFPNPNLATQFLLQNSLQALAQFQALQQMKQQQREDPLPSYSTPLAKSPLRSPSLSPVPRHSKSQQRTPPNSMTANS LGMSSAVMTPNTPSMQQQPQLQQSTPK----------------------------------------------------- -------PTSGLTVASAMAKLEQSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLQKWLEDADS---TVAKSGGGVFNINTMTS TLSSTPESILGRRRKKRTSIETTVRTTLEKAFLM-NCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEKRINPSLDLDS PTGTPLSSHAFGYPPQ---------------------------------ALNMSHMQMEGG------------------- ----------------------------SGSFCGSSISSGE--------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Homo_sapiens_POU2F2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------SMGAPEIR MSKPLEAEKQG--LDS-----------------------PSEHTDTER--NGPDTNHQNPQNKTSPFSVSP---TGPSTK VGILSGLHLTFWGPGPCLSPPQ---------------------------------------------------------- ---------------------------------------------------------IKAEDPSGDSAPAAPLP------ ---------------------PQPAQPHLPQAQLMLTGS----QLAGDIQQLLQLQQLVLVPG----HHLQPPAQFLLPQ ------------------------AQQS------------------------------------------QPGLLPTPNL FQ---------------------------------------------------------------------LPQQTQGAL LTSQPRAGLPTQ-------------------------------------------------------------------- --------------PPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLN------DAETMSVDSSLPSPNQLS SPSLGFDGLPGRRRKKRTSIETNVRFALEKSFLA-NQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRIN-PCS--- -AAPMLPSPG-------KPASYSPHMV--------------------TPQGGAGTLPLSQ-------------------- ASSSLSTT-------------------VTTLSSAVGTLHPS--------------RTAGGG------------------- ------GGGGGAAPPLNSIPSVTPP--------------PPATTNSTNPSPQ------------GSHSAIGLSGLNPSTG S----------------------------------------------------TMVGLSSGLSPALMSNNPLATIQGACC LMSHPSSPALSSGASSPAIAAPAMPSCP-CSLHCLPLHTHLTFGEGVRGADG--GQWDRWGDGGHSGQDAGRQRSPLARH ----ALSPASLSPRQPWPLVEPCPLPALMAAGIWCWGQPVQPRGALAW------------------------ >Macaca_mulatta_POU2F2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MVHSSMGAPEIR MSKPLEAEKQG--LDS-----------------------PSEHTDTER--NGPDTNHQNPQNKTSPFSVSP---TGPSTK E------------------------------------------------------------------------------- ----------------------------------------------------------KAEDPSGDSAPAAPLP------ ---------------------PQPTQPHLPQAQLMLTGS----QLAGDIQQLLQLQQLVLVPG----HHLQPPAQFLLPQ ------------------------AQQS------------------------------------------QPGLLPTPNL FQ---------------------------------------------------------------------LPQQTQGAL LTSQPRAGLPTQ-------------------------------------------------------------------- --------------PPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLN------DAETMSVDSSLPSPNQLS SPSLGFDGLPGRRRKKRTSIETNVRFALEKSFLA-NQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRIN-PCS--- -AAPMLPSPG-------KPASYSPHMV--------------------TPQGGAGTLPLSQ-------------------- ASSSLSTT-------------------VTTLSSAVGTLHPS--------------RTAGGG------------------- ------GSGGGAVPP-NSIPSVTPP--------------PPATTNSTNPSPQ------------GSHSAIGLSGLNPSTG ---------------------------------------------------------------PGLWWN----------- -------------------PAPYQ-------------------------------------------------------- ------------------------------------------------------------------------ >Mus_musculus_POU2F2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MVHSSMGAPEIR MSKPLEAEKQS--LDS-----------------------PSEHTDTER--NGPDINHQNPQNKASPFSVSP---TGPSTK VGILSGLHLTFWGPGPCLSPPQ---------------------------------------------------------- ---------------------------------------------------------IKAEDPSGDSAPAAPPP------ ---------------------PQPAQPHLPQAQLMLTGS----QLAGDIQQLLQLQQLVLVPG----HHLQPPAQFLLPQ ------------------------AQQS------------------------------------------QPGLLPTPNL FQ---------------------------------------------------------------------LPQQTQGAL LTSQPRAGLPTQ-------------------------------------------------------------------- --------------PPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLN------DAETMSVDSSLPSPNQLS SPSLGFDGLPGRRRKKRTSIETNVRFALEKSFLA-NQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRIN-PCS--- -AAPMLPSPG-------KPTSYSPHLV--------------------TPQGGAGTLPLSQ-------------------- ASSSLSTT-------------------VTTLSSAVGTLHPS--------------RTAGGG------------------- ------GGGGGAAPPLNSIPSVTPP--------------PPATTNSTNPSPQ------------GSHSAIGLSGLNPSAG S----------------------------------------------------TMVGLSSGLSPALMSNNP--------- -------------------LATIQGACC-LMSPHCHQSCPLLG------------------------------------- -----LEPTLPHCCPSHAIPPPCSLHCSPLHPHLSSGKV--------------------------------- >Danio_rerio_POU2F2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------AHFFSNMTKTGPVASMDYSHMWFPDIR MSKPVEVENPA--ADS-----------------------PMESTGTVQKRNGSDSNNQVQPMKINPFSISPTLSSSI--- -------------------------------------------------------------------------------- ---------------------------------------------------------KAKVEDCGEMSPTT--------- ---------------------ATPAQTALTHTQLMLTGG----QLAGDIQQLLQLQQLVLVPG----HTLPSPAQFLLPQ ------------------------TQQG------------------------------------------QQGLLSTPNL IP---------------------------------------------------------------------LPQQNQGSL LAAPPRLSLQAQ-REKIAESS----------------------------------------------------------- --------------LNTVTTVTSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLT-----DA-ETMSMDSTLPSPSSLS SPSLGFEGLPGRRRKKRTSIETNVRVALEHSFLA-NQKPTSEEILLISEKLNMEKEVIRVWFCNRRQKEKRIN-PSS--- -ATPPLPSQP--QPTSHKPPCYSPHMM--------------------------SSQGPRQ-------------------- TVGSLS-TAVTT-------------------MSSVCPMTP---------------------------------------- -----------SGPSLSSTPSPVTP--------------PP--RGDSSPAPP---------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------THSTLNLSTGS WHK--KNGDVSNYITDFAASLSSSSQWWPAPHFQS------------------------------------- >Danio_rerio_POU2F2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------TKNSVMFVVYFSFMWLIDIR MSKAMEDDKMG--TEL-----------------------PVDSTGGSE-KRGLEKYSQTQPMKTSPFCLSPAP------- -------SNT---------------------------------------------------------------------- ---------------------------------------------------------KVKGEEAAEMTSVHAPP------ ---------------------PPPAQPALPHTQLMLAGS----QLAGDIQQLLQLQQLVLMPG----HPLQSPAQFLLPQ -AQ---------------------AQQG------------------------------------------QQGLLSTPNL IP---------------------------------------------------------------------LPQQSPGSL LTTPPRLGLQAQVCHKITVKAPP--------------------------------------------------------- --------------MSSAPTVTPHPEEPSDLEELEQFARTFKLQDVRLIFLQGDVGMAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLS-----DAPETMAIDNMLPSPSSLS SPLLGFEGLPGRRRKKRTSIETNVRIALERNFIS-NQKPTSEEILLMAEQLNMEKEVIRVWFCNRRQKEKRIN-PSS--- -ATPPLPTQP-T-APTHKAPCYSPHMM--------------------------SSQALAQ-------------------- VATSLSTT------------------AVSPTPSVACPLTS---------------------------------------- ----------SGHAAMSSAPSSVTP--------------PP--LSTVSPTPP---------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------SLSSPGLNTGG WKQLFKCHDIINSFLFCHLNHSSGCQWWPDVHFRS------------------------------------- >Strongylocentrotus_purpuratus_POU2F2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------MSTETAENSPAKKSKEVVMIQAGGGDASQQTRPQTATPVATSVVPVSITPTQMIQVMSSSGQPT LVHPTNVMTAQGLAAA-----------------------GFLSLPTAGSPAPGHCRHLQQPQQFLVNPGSGQVLLQTLPF AQAGATPIALANFQGAQQVALATSAAQMLKSPTNQIKMATMQSAAQQ-------------------------LQAAAAAS TSQVQTTQTTAGTSQAVAAAAAQLAAPVQTITTALTPQQLQLLQQQQVQVISPFADITRMWANQQQPQQQQQQQNQQFQQ QNQQMQQQQTLPPQQQQQQGVQQPKIAPQLPGQLQQISAQDLQQLQQLQQQNPNLQQYVFLQAPSQVPTNMQQAQQLLLQ QQQ---------------------QQQQQQQQ--------------------------NLAQQQGLLQQSHVGMLPQQSL IQAQAINAQQQLQQ--------------------------------------------------QALTA--AGIQSVSRA AAAATTNAQSVTAQQQLQLQQAQ--------------------------------------------------------- ---KQGGGVTSVAAQPIPSIPHSHVEEQTDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLQKWLDD------ADTTVSNPALLGPHNSP EG-------INRRRKKRTSIETNIRISLEKSFL-MQPKPTSEEIVLLGEQMGMEKEVVRVWFCNRRQKEKRINPPVSSLN -LQNLMAHHTSHSISSMNLSPGVTQIQ-----------------------QTNPGTPVTPS------------------T PISSKIISSISAAAATN-------GQNPIPMQAKTVAIQSSGR------------------------------------- --------TIAVNLVSATNGQVTAT--------------PVSTVTPIALTAVTPSTSGQPQMSLINSATHRLS------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Homo_sapiens_POU2F3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MESPRTAKGGRD IKMSGDVADSTD-ARS-----------------------TLSQVEPGNDRNGLDFNRQIKTEDLSDSLQQT--------- -------------------------------------------------------------------------------- -------------------------------------------------------------LSHRPCHLSQGPAMM---- ---------------------SGNQMSGLNASPC------------QDMASLHPLQQLVLVP-----GHLQSVSQFLLSQ ------------------------TQPG------------------------------------------QQGL--QPNL LPF--------------------------------------------------------------------P-QQQSGLL -LPQTGPGLASQAFGHPGLPGSS--------------------------------------------------------- --LEPHLEASQHLPVPKHLPSSGGADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLND------AESSPSDPSVSTPSSYP SLSEVFG----RKRKKRTSIETNIRLTLEKRFQD-NPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATP- -IKPPVYNSR--------LVSPSGSLG---------------------PLSVPPVHST-MP------------------G TVTSSCSPGN-----------------NSRPSSPGSGLHASSP------------------------------------- ---------TASQNNSKAAVNSAS---------------SFNSSGSWY-RWN---------------HSTYLH------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Macaca_mulatta_POU2F3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MVNLESMH--TD IKMSGDVADSTD-ARN-----------------------TLSQVEPGNDRNGLDFNRQIKTEDLSDSLQQT--------- -------------------------------------------------------------------------------- -------------------------------------------------------------LSHRPCHLSQGPAMM---- ---------------------SGNQMSGVNASPC------------QDMASLHPLQQLVLVP-----GHLQSVSQFLLSQ ------------------------TQPG------------------------------------------QQGL--QPNL LPF--------------------------------------------------------------------P-QQQSSLL -LPQTGPGLASQAVGRPGLPGSS--------------------------------------------------------- --LEPHLEASQHLPVSKHLPSSGGADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLND------AESSPSDPSVSTPSSYP SLSEVFG----RKRKKRTSIETNIRLTLEKRFQD-NPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATP- -IKPPVYNSR--------LVSPSGSLG---------------------PLSVPPVHST-MP------------------G TVTSSCSPGN-----------------NSRPSSPGSGLHASSP------------------------------------- ---------TASQNNSKASVNSAS---------------SFNSSGSWY-RWN---------------HPTYLH------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Mus_musculus_POU2F3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MVNLEPMH--TE IKMSGDVADSTD-TRS-----------------------TFGQVEPGNDRNGLDFNRQIKTEDLGDSLQQT--------- -------------------------------------------------------------------------------- -------------------------------------------------------------LSHRPCHLSQGPTMM---- ---------------------PGNQMSG-------------------DMASLHPLQQLVLVP-----GHLQSVSQFLLSQ ------------------------TPPG------------------------------------------QQGL--QPNL LSF--------------------------------------------------------------------P-QQQSTLL -LPQTGPGLASQAVGRPGLSGSS--------------------------------------------------------- --LEPHLDAPQHLPGPKHLPGPGGNDEPTDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLND------AESSPSDPSASTPSSYP TLSEVFG----RKRKKRTSIETNIRLTLEKRFQD-NPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATP- -VKPPIYNSR--------LVSPSGSLG---------------------PLSVPPVHST-MP------------------G TVTSSCSPGN-----------------NSRPSSPGSGLHASSP------------------------------------- ---------TASQNNSKAAMNSSSSS-------------SFNSSGSWY-RWN---------------HPTYLH------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Gallus_gallus_POU2F3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MSSDAADSTD-TRH-----------------------EPDQVEPGSEQNGLDFNRQIKTEDLSDSLQST--------- -------------------------------------------------------------------------------- -------------------------------------------------------------IPPRSGHLVQGSSMM---- ---------------------PGSQIAG-------------------DMSSLHTLQQLVLLP-----GHMQSVPQFLLSQ ------------------------SQAG------------------------------------------QQAL--QPNI LSF--------------------------------------------------------------------P-QQQGSLL -LSQPGPSLASQAVGRSGLPGSS--------------------------------------------------------- --VEPHLDVPQHLQVAKHLTPSGASEEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLSD------AESAPLDSSMSTPSSYP SVNEMFG----RKRKKRTSIETNIRSTLEKRFQD-NPKPSSEEISLIAEQLSMEKEVVRVWFCNRRQKEKRISCPMPSP- -IKSPIYNSR--------LVSTSGSLG---------------------PLSVNPVHST-MP------------------G TVTSSCSPGN-----------------SSRPSSPGSALHASSP------------------------------------- ---------STAQSNSKAAMNSSG----------------FNSSGSWY-RWN---------------QPTYLH------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Danio_rerio_POU2F3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MSTDAVEQTE-SQH-----------------------EQADIE----QNGIDFTRQIKTENLNDSPHSG--------- -------------------------------------------------------------------------------- -------------------------------------------------------------SSHKTCHLTQG-SPL---- ---------------------PPGQLTG--------------------MPSLHPLPQLVLMPG----SHLSSPSSFLLSQ ------------------------AQSGH----------------------------------------QGLSLL-PPNL LSL--------------------------------------------------------------------PSQTQTGLL -PHQPGLALTPQAMGRSGLAGSS--------------------------------------------------------- --MDGHLDMS-HLQVPKHVGSP--QDEPNDLEELEQFAKAFKQRRIKLGFTQGDVGLAMGKLYGN---DFSQTTIS---- --------------------------------RFEALNLSFKNMCKLKPLLEKWLSD------AENSPSD-TMTNTTTLP PLMEGYG----RKRKKRTSIETNIKLTLEKRFLD-NPKPNSEEITLISEQLAMEKEVVRVWFCNRRQKEKRIYCPVSTSP -IKPHNFNPR--------LPS------------------------------TSRSFSPLTS------------------G GVSSSSSPGS-----------------PSRGSSPGTLSTTSSP------------------------------------- ---------LTAQSVN------QT----------------FNTAGSWY-RWNT---------------ASYHH------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Homo_sapiens_POU3F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATTAQYLPRGPGGGAGGTGPLMHPDA-----------------------AAAAAAAAA AERLHAGAAYREVQKL-----------------------MHHEWLG----AGAGHPVGLAHPQ---WLP----------- ---------------TGGGGGG-DWAGGPHLEHG---------------------------------------------- -------------------------------------------------------KAGGGGTGRAD-DGGGG-------- --------------------GGFHARLVHQGAAHAGAAWAQGSTAHH--------LGPAMSPSPGASGGHQPQPLGLYAQ -AAYPG----------------------------------------------------------------GGGGGLAGML AAGGGGAGPG---------------------------------------------------------LHHALHEDG--HE AQLEPSPPPHLGAHGHAHGHAHAGGLHAAA-------------------------------------------------- ----AHLHPGAGGGGSS--VGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLNKWLEE----------------TDSSSGS PTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLK-CPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPA----- ---AGAGHPP-----------MDDVYAP------------------------GELGP---GGGGASPPSAPPPPPPAALH HHHHHT----------------------LPGSVQ---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Mus_musculus_POU3F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATTAQYLPRGPGGGAGGTGPLMHPD-------------------------AAAAAAAA AERLHAGAAYREVQKL-----------------------MHHEWLG----AGAGHPVGLAHPQ---WLP----------- ---------------TGGGGGG-DWAGGPHLEHG---------------------------------------------- -------------------------------------------------------KAGGGGTGRAD-DGGGG-------- --------------------GGFHARLVHQGAAHAGAAWAQGGTAHH--------LGPAMSPSPGAGGGHQPQPLGLYAQ -AAYPG----------------------------------------------------------------GGGGGLAGML AAGGGGAGPG---------------------------------------------------------LHHALHEDG--HE AQLEPSPPPHLGAHGHAHGHAHAGGLHAAA-------------------------------------------------- ----AHLHPGAGGGGSS--VGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLNKWLEE----------------TDSSSGS PTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLK-CPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPA----- ---AGAGHPP-----------MDDVYAP------------------------GELGP---GGGSASPPSAPPPPPPAALH HHHHHT----------------------LPGSVQ---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Danio_rerio_POU3F1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATTAQYIPR---NNSLPSNPLMHPD--------------------------------- SDRMHQGTTYREVQKM-----------------------MHHEYLQGLA-TNTGHPMSLTHHQ---WLP----------- ---------------TSNTDWTSGTHIG-QAEHN---------------------------------------------- -------------------------------------------------------KASVQS-REDL-GNG---------- ---------------------YHRSHLVHQPTQNSHHGSWAPTTTHH--------LSP-LSP---ASNGHQS---LVYSQ ----------------------------------------------------------------------TGYT----ML SPQP-SLHHG---------------------------------------------------------LRDPLHDDAGSHD NQME-SPQQPFSHH------------------------------------------------------------------ --------------------QDHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLNKWLEE----------------TDSNTGS PTNLDKIAAQGRKRKKRTSIEVGVKGALENHFLK-CPKPSAHEITTLAGTLQLEKEVVRVWFCNRRQKEKRMTP------ ---VGVPHPT-----------MEDVYSQ------------------------AETPP----------------------- --LHHT----------------------LQSPVQ---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Caenorhabditis_elegans_POU3F1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MLIPSSSSIPSSLSASASDS-EPSSLNGSGIS-----DQNILPN------YHLH------------------------- ------------------HHLINENEMEA---------------------------ANY----------------AQVIK PTCEAFQDWPHTPMLY-----------------------------------QQPQLHFMLPQHDWAYP-----------H LAQSLPP------------------------------------------------------------------------- -------------------------------------------------------PHHLTPSTAAVAAATIASQSSIIN- -------------------------QTSVVTSTPS----------------------CQIKQ-------------EVE-- -----------------------RP-------------------------------------------------EIIQRL MP---PWP---------------------------------------------------------------PAYQFSCDD SGSVSGAGGPHQPLSDISDDSEQTCP------------------------------------------------------ -------------------------------DDLEGFAKQFKQRRIKLGYTQADVGVALGTLYGN---IFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLFKWLEEADS---TTGSPNS---TFEKMTG --------QAGRKRKKRTSIEVNVKSRLEFHFQS-NQKPNAQEITQVAMELQLEKEVVRVWFCNRRQKEKRIAPN-QYDA PHPMALNN---GYP------------------------------------MTADLFPYQAV------------------- ----------------------------VNHYTQQSPRQQ---------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Homo_sapiens_POU3F2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATAASNHYSLL---------------------------------------TSSASIVH AEPPGGMQQGAGGYRE-----------------------AQSLVQGDYGALQSNGHPLSHAHQ---WIT-ALSHGGGGGG GGGG-GGGGGGGGGGGDGSPWSTSPLG-QPDIKPSVVVQQGGRGDE---------------------------------- -------------------------------------------LHGPGALQQQHQQQQQQQQQQQQ-QQQQQQQQQ---- ----------------------RPPHLVHHAAN--HHPGPGAWRSA----------AAAAHLPPSMGASNG---GLLYSQ ----------------------------------------------------------------------PS-FTVNGML GAGGQP---------------------------------------------------------------AGLHHHGLRDA HDEPHHADHHPHPHSHPHQQPPPPPPP----------------------------------------------------- -----QGPPGHPGAHHD----PHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLNKWLEE----------------ADSSSGS PTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLK-CPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPP----- --GGTLPGA-------------EDVYGG-----------------------SRDTPP----------------------- ---HHG----------------------VQTPVQ---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Mus_musculus_POU3F2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATAASNHYSLL---------------------------------------TSSASIVH AEPPGGMQQGAGGYRE-----------------------AQSLVQGDYGALQSNGHPLSHAHQ---WIT-ALSHGGGGGG GGGG-GGGGGGGGGGGDGSPWSTSPLG-QPDIKPSVVVQQGGRGDE---------------------------------- -------------------------------------------LHGPGALQQQHQQQQQQQQQQQQ-QQQQQQQQQQQ-- ----------------------RPPHLVHHAAN--HHPGPGAWRSA----------AAAAHLPPSMGASNG---GLLYSQ ----------------------------------------------------------------------PS-FTVNGML GAGGQP---------------------------------------------------------------AGLHHHGLRDA HDEPHHADHHPHPHSHPHQQPPPPPPP----------------------------------------------------- -----QGPPGHPGAHHD----PHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLNKWLEE----------------ADSSSGS PTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLK-CPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPP----- --GGTLPGA-------------EDVYGG-----------------------SRDTPP----------------------- ---HHG----------------------VQTPVQ---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Anolis_carolinensis_POU3F2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATTASNHYSLL---------------------------------------AASSPMVH AEPPGSMQPG----AG-----------------------YRDAVQADYAALQSNGHPLSHAHQ---WIA----------- -------------------ALSHGGGG----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------GGGGGGGGG----------GGGGGGGGGGGSSGGD--SPWSTS ----------------------------------------------------------------------PD-IKPSEPP PPPPPP---------------------------------------------------------------PPPHHPDHLSQ QQQQQQQQHHAPPPPHHHHP------------------------------------------------------------ ------HHPAHHPHHHE----AHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLNKWLEE----------------ADSSSGS PTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLK-CPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPP----- --GGTLPGA-------------EDVYGA-----------------------SRDTPPP---------------------- ---HHG----------------------VQTPVQ---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Danio_rerio_POU3F2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATTASNHYNIL---------------------------------------TSSPSIVH SEPGSMQQAT--AYRD-----------------------AQTLLQSDYS-LQSNSHPLSHAHQ---WIT-ALSHG----- ----------------EGGPWSSSPLG-EQDIKP---------------------------------------------- ------------------------------------------------------AVQSP-RDEMHN-SS-NLQHQS---- ----------------------RPPHLVHQTHG--NHHDSRAWRTT----------TAA-HIP-SMATSNGQ--SLIYSQ ----------------------------------------------------------------------PS-FSVNGLI -PGSG----------------------------------------------------------------QGIHHHSMRDA HEDHHSPHLSDHGHPPSQHQ------------------------------------------------------------ --------HQS-HQSHH----DHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLNKWLEE----------------ADSTSGS PTSLDKIAAQGRKRKKRTSIEVSVKGALESHFLK-CPKPAASEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPP----- --GGPLPGT-------------EDVYG--------------------------DTPP----------------------- ---HHG----------------------VQTPVQ---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Danio_rerio_POU3F2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATAASNHYSIL---------------------------------------TSS----- AEPGSMQQTPPPAYRD-----------------------AHSLLQSEYTTLQSSGGTLGHAHQ---WLTAALSHGG---- ----------------EGSPWPASPLG-EQDIKP---------------------------------------------- ------------------------------------------------------VEE--------------LQHSP---- ----------------------RQAHLVPQSQ----HHETAAWRAT----------TTA-HMP-SMSTSNGQ--SLIYSQ ----------------------------------------------------------------------PG-Y------ ----------------------------------------------------------------------GEMHH----- -EEHHSPHLSEHGHPQS--------------------------------------------------------------- ---------------------LHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLNKWLEE----------------ADSTSGS PTSLDKIAAQGRKRKKRTSIEVSVKGALESHFLK-CPKPGASEINSLADSLQLEKEVVRVWFCNRRQKEKRMTPQ----- --NGPMAGS-------------EDVYG--------------------------DASP----------------------- ---HHG----------------------AQTPVP---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Drosophila_melanogaster_POU3F2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MAATSYMTPP-----------------------------------------SGDLDM ALGGGGYHTS--SPRS-----------------------AADAGEMKYMQHHHHHHAAAAAAA---HHQ----------- ------------------LPSSPSPNGQGNGGGLG--------------------------------------------- ------------------------------------------------------LGSGSGLGSWSA-LHPDPWMQT---- ------------------------HHTHHLPAA--AAVASAADTVK----------QEMSHLSQQTRIQQGM--ASPHAA ----------------------------------------------------------------------WH-APHAGHY APTGGS---------------------------------------------------------------PLQYHHAMNGM LHHPAHAVAAAHHQSVAPLHHTLRGESP---------------------------------------------------- -----QLHIHHHMGGGDRDAISGGEEDTPTSDDLEAFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLQKWLEE----------------ADSTTGS PTSIDKIAAQGRKRKKRTSIEVSVKGALEQHFHK-QPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPNTLG- --GDMMDGMPPGHMHHGGYHPHHDMHGS-----------------------PMGTHSH---------------------- ---SHSPPMLSPQNMQSSAVAAHQLAAH?QSEIQESNSAAAASTPASLNSLSQQQQQQQQQQQQQHQQQQQHQQQQHTPN TPSSSAGSSATMTSQVMSPQSPLGSSSAGNQANNNNNNNNNNNSSTNNNNNNNNNEEQVKHHQQQQQQQQASSIAAAAAA AMYMDPMRYQHPHHPHPHPHQHPHLNPAHHPHLFHTSDQLQHSQQQTVGGTSSNSQLSPGAGSNSGLPLQPPSSASPAGS ASSVLGGHLNLNPLHQHHHYQHHHHQQHHHHQQQQQQLHARRLFELSLQFGAAAAPGAVRHFNSFGGAGGAGGE------ ------------------------------------------------------------------------ >Homo_sapiens_POU3F3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATAASNPYLPGNSLL-AAGSIVHSDAAGAGGGGGGGGGGGGGGAGGGGGGMQPGSAAV T--SGAYRGDPSSVKM-----------------------VQSDFMQGAMAASNGGHMLSHAHQ---WVT-ALPHAAAAAA AAAAAAV--------EASSPWSGSAVGMAGSPQQPPQPPPPPP------------------------------------- ---------------------------------------------------QGPDVKGG-AGRDDL-HAGTALHHRG--- -----------------------PPHLGPPPPPP-HQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQPPPQSLLYSQ ----------------------------------------------------------------------PGGFTVNGML SAPPGPGGGGGGA----------------------------------------------------GGGAQSLVHPGLVRG DTPELAEHH-HHHHHHAHP-HPPHPHHAQGPPH----------------------------------------------- HGGGGGG-AGPGLNSHD----PHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLNKWLEE----------------ADSSTGS PTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLK-CPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQ-- ---QQTPDDV------------YSQVGT----------------------VSADTPPP---------------------- ---HHG----------------------LQTSVQ---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Mus_musculus_POU3F3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATAASNPYLPGNSLL-TAGSIVHSDAAGA-GGGGGGGGGGGGGAGGGGGGMQPGSAAV T--SGAYRGDPSSVKM-----------------------VQSDFMQGAMAASNGGHMLSHAHQ---WVT-ALPHAAAAAA AAAAAAV--------EASSPWSGSAVGMAGSPQQPPQPPPPPP------------------------------------- ---------------------------------------------------QGPDVKGG-AGREDL-HAGTALHHRG--- -----------------------PPHLGPPPPPP-HQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQPPPQSLLYSQ ----------------------------------------------------------------------PGGFTVNGML SAPPGPGGGGGGA----------------------------------------------------GGGAQSLVHPGLVRG DTPELAEHH-HHHHHHAHP-HPPHPHHAQGPPH----------------------------------------------- HGGGG---AGPGLNSHD----PHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLNKWLEE----------------ADSSTGS PTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLK-CPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQ-- ---QQTPDDV------------YSQVGT----------------------VSADTPPP---------------------- ---HHG----------------------LQTSVQ---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Danio_rerio_POU3F3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATAASNPYLAS-SSILSSGSIVHSDS--------------------GGG-MQQGSAAV TSVSGGYRGDP-TVKM-----------------------VQSDFMQGAMAASNGGHMLSHAHQ---WVT-SLPH-AAAAA AAAAVAAA-------EAGSPWSSSPVGMTGSPQ----------------------------------------------- ----------------------------------------------------QQDVKNN-SGRDDL-HSGTALHHR---- -----------------------APHLGP------HQTHAGAWGS-----------TTAAHIPSLTGSQQQ-QQSLIYSQ ----------------------------------------------------------------------PGGFTVNGML SP----------------------------------------------------------------PGSQSLVHPGLVRG DTPELDHSSHHHHHHHQH-------------------------------------------------------------- ---QHHQQAHHGVNSHD----PHSDEDTPTSDDLEHFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLNKWLEE----------------ADSSTGS PTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLK-CPKPSAQEITSLADNLQLEKEVVRVWFCNRRQKEKRMTPPGV--- ---PQTPEDV------------YSQVGN----------------------VSADTPPP---------------------- ---SMD----------------------CKRMFSET-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Danio_rerio_POU3F3_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATAASNPYLAS-STILSSASLVHSES--------------------GGGGMQPGSGAV TSVSGGYRGDP-TVKM-----------------------VQSDFMQGAMAASNGGHMLSHAHQ---WVT-SLPHAAAAAA AAAAAAAA-------EAGSPWSSSPVGMAGSPQ----------------------------------------------- ----------------------------------------------------QQDVKSS-SNREDL-HSGTALHHR---- -----------------------PSHLGA------HQSHQSAWGG-----------TTASHISTITGGQQQSQQSLIYSQ ----------------------------------------------------------------------PGGFTVNGML NP------------------------------------------------------------------PGSLVHPGLMRG ESPEMDHHHHHHHHQQQHP------------------------------------------------------------- -HHHHHHQHHAGVNSHD----SHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEALQLSFKNMCKLKPLLNKWLEE----------------ADSTTGS PTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLK-CPKPSAQEITSLADNLQLEKEVVRVWFCNRRQKEKRMTPPGV--- ---PQTPEDV------------YTHAGN----------------------VSADTPPP---------------------- ---SMD----------------------CKREFCGRLLKRCKFER----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Homo_sapiens_POU3F4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATAASNPYSILS----------------------------------------STSLVH ADSA-GMQQGS-PFR------------------------NPQKLLQSDYLQGVPSNGHPLGHH---WVT----------- -------------SLSDGGPWSSTLATSPLD------------------------------------------------- -------------------------------------------------------QQDVKPGREDL-QLGAIIHHR---- -----------------------SPHVAHHSPHTN----HPN--------------AWGASPAPNPSITSSGQPLNVYSQ -----------------------------------------------------------------------PGFTVSGML EHGG--------------------------------------------------------------------LTPPPAAA SAQSLHPVLRE--------------------------------------------------------------------- ------PPDHGELGSHH--CQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGN---VFSQTTIC---- --------------------------------RFEGLQLSFKNMCKLKPLLNKWLEE----------------ADSSTGS PTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLK-CPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPP----- ----GDQQP-------------HEVYS-----------------------HTVKTDTS---------------------- ---CHDL------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------ >Macaca_mulatta_POU3F4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MATAASNPYSILS-------