>Homo_sapiens_PKD1 ------------------------MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGL RTLGPALRIPADATALDVSHNLLRA---LDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGL AWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDN----SSGTVAAVSFSAAHEGLLQPEA CSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTCRGPTLLQHVFP-ASPGATLVGPHGPLASGQ LAAFHIAAPLPVTATRWDFGDGSAEVDAAGPA----ASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCP SSVQSDESLD--LSIQNRGGSGLEAAYSIVALGEEPAR-----AVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQ AWAGAALAMVDSPAVQRFLVSRVTR--SLDVWIGFSTVQGVE--VGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGP TGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGDLQGPLT-PLAQQDGLSAP-HEPVEVMVFPGLRLSREAFLTT AEFGTQELRRPAQLRLQVYRLLST----------AGTPENGSEPESRSPDNR-TQLAPACMPGGRWCPGANICLPLDASC HPQACANGCT-------SGP-GLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPG-------- ALLHCSP---APGHPGPRAPYLSANASSWLPHLPAQLE--------------------------GTWA--CPACALRLLA ATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAP-RDGRLYVPTNG-SALVLQVDS GANATATARWPGGSVSARFENVCPALVATFVPGCPWETND---------TLFSVVAL---PWLSEGEHVVDVVVENSASR ANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVV-----EAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFKL SLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNAT------LALTAGVLVDSAVEVAFLWTFGDGEQ-ALHQF QPPYNESFPVPDPSVAQVLVEHNVMHTYAA---PGEYLLTVLASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPV TFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASR---GTYHVRLEVNNTVSGAAAQA-DVRVFEELRGLSVDMS LAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLS-GPEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRV EPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVN---RAHYFTSICV EPEVGNVTLQPERQFVQLGDEAWLVACAWP--PFPYRYTWDFGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAA NDSALVEVQEPVLVTSIKVNGSL--GLELQQPYLFSAVGRGRPASYLWDLGDGGWLEG-PEVTHAYNSTGDFTVRVAGWN EVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV TAENEVGSAQDSIFVYVLQLIEGLQVVGGG-------------RYFPTNHTVQLQAVVRDGTNVSYSWTAWRDR-G--PA LAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVEPVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLE -EGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQVPVSGLSIRAS-EPGGSFVAAGSSVPFWGQLATGT NVSWCWAVP-----GGS-SKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTAEEPIVGLVLWASSKVVAPGQLVHF QILLAAGSAVTFRLQVGG--ANPEVLP-GPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSGLQVPNCCEPGI ATGTERNFTARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQY VALQSGP--CFTNRSAQFEAATSPSPRRVAYHWDFGDGSP-GQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVT VQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPAR-------------VALP GVDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLE DGDQTPLSFHWACVASTQREAGG--------CALNFGP---RGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTV LIRSGRVPIVSLECVSCKAQA--VYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLR RGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLG--------------AVHALTTKVHFE-----C TGWHDAEDAGAPLVYALLLRRCR--QGHCEEFCVYKGSLSSYGAVLPPGFRP----HFEVGLAVVVQDQLGAAVVALNRS LAITLPEPNGSATG----LTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNE----YERALDVAAEPKHERQHRAQ IRKNITETLVSLRVHTVD---DIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILN ITGDLIHLASSDVRAP--------------------------QPSELGAESPSRMVASQAYNLTSALMRILMRSRVLNEE PLTLAGEEIVAQGKRSDPRSLLCYGGAPGPG---CHFSIPEAFSGALA----------NLSDVVQLIFLVDS--NPFP-F GYISNYTVSTKVASMAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSAN----SANSVVVQPQASVGAVVTLD SSNPAAGLHLQLNYTLLDG-----HYLSEEPEPYLAVYLHSEPRPNEH-NCSASRRIRPESLQG---ADHRPYTFFISPG SRDPAGSYHLNLSSHFR----W-----SALQVSVGLYTSLCQYFSEEDMVWRTEGLL----------------------- ----PLEETSP---------------------RQAVCLTRHLTAFGAS--LFVPPSHVRFVFPEPTADVNYIVMLTCAVC LVTYMVMAAILHKLDQLDASR-GRAIPFCGQ----RGRFKYEILVKTGWGRGSGTTAHV--G-----IMLYG-VDSRSGH RHLDGDRA---FHRN-----------SLDIFRIATPHSLGSVWKIRVWHDNKGLSP----AWFLQHVIVRDLQTARS--- ----------AFFLVNDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPP--------- -----RSRFTRIQRATCCVLLICLFLGANAVWYGAVGDSAYSTGHVSRLSPLSVDTVAVG-------------------- ---------------LVSSVVVYPVYLAILFLFRMSRSKVAGSPSPTPA-GQQVLDIDSCLDSSVLDSSFLTFSGLHAEQ AFVGQMK---------SDLFLDDSKSLVCWPSGEGTLSWPDLLSDPSIVGSN---------------------------- ----LRQLARGQAGHGLGPE-------EDGFSLASPYSPAKSFSASDEDLIQQVLAEGVSSPAPTQDT------------ -------------------------------------------------------------------------------- -----------------------------------------------------------------HMETDLLSSLSSTPG EKTETLA--LQRLGELGPP------SPGLNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVG --ASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSL----------------VAKRLHPDEDDTLVESP-AVTP VS---------------------ARVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDAS---- -CHGHAY--RLQSAIKQELHS----------RAFLAITRSEELWPWMAHVLLP-YVHGN----------QSSPE-----L GPPRLRQVRLQEALYPDP-----------------PGPRVHTCSAAG-GFSTSDYDVGWE-------------------- ---------SPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRY SPAVGLHAAVTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVC---LLLFAVHFAVAEARTWHREG-------- -------------------------------------------------------------RWRVLRLGAWARWLLVALT AATALVRLAQLGAADRQWTRFVRGRPRRFT---------------SFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVR QWSVFGKTLCRALPELLGVT-----LGLVVLGVAYAQLAILLVSSCVDSLWSVAQALLVLCPGTGLST------------ --LCPAESWHLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRH KVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTS--SSQLDGLS------------------------------- -VSLGRLGTRCEPEP--SRLQAVFEALLTQFDRLNQATEDVYQLEQQLHSLQGRRS------------------------ -------------------------------------------------------------------------SRAPAGS SRGPSPGLRPALPSRLARASRGVDLATGPS---------------RTPLRAKNKVHPSST-------------------- ------------------------------------------------------------------------------ >Gorilla_gorilla_PKD1 ------------------------MPPAAPVRLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGL RTLGPALRIPADATALDVSHNLLRA---LDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGL AWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDN----SSGTVAAVSFSAAHEGLLQPEA CSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLS-CSSPPPPPAPTCRGRTLLQHVFP-ASPGAALVGPHGPLASGR LAAFHIAAPLPVTATRWDFGDGSPEVDAAGPA----ASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPATLELVCP SSVQSDESLD--LSIRNRGGSGLEAAYSIVALGEEPAR-----AVHPLCPSDTEIFPGSGHCYRLVVEKAAWLQAQEQCR AWAGAALAMVDSPAVQRFLVSRVTR--SLDVWIGFSTVQGVE--VGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGP TGWCNTDLCSAPHSYVCELRPGGPVQDAENLLVGAPSGDLQGPLT-PLAQQDGLSAP-HEPVEVMVFPGLRLSREAFLTT AEFGTQELRRPAQLRLQVYRLLST----------AGTPENGSEPESRSPDNR-TQLVPACMPGGCWCPGANICLPLDASC HPQACANGCT-------SGP-GLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPS-------- ALLHCSP---APSHPGPQAPYLSANASSWLPHLPAQLE--------------------------GTWA--CPACALRLLA ATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAP-HHGRLYVPTNG-SALVLQVDS GANATATARWPGGSVSARFENACPALVATFVPGCPWETND---------TLFSAVAL---PWLSEGEHVMDVVVENSASR ANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVV-----EAGSDMVFRWTINDKQSLTFQNVVFNVI-QSAAVFKL SLTASNHVSNVTVNYNVTVERMNRMQGLRVSTVPAVLSPNAT------LALTAGVLVDSAVEVAFLWTFGDGEQ-ALHQF QPPYNESFPVPDPSVAQVLVEHNVTHTYAA---PGEYILTVLASNAFENLTQQVPVSVRTSLPSVAVGVSDGVLVAGRPV TFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASR---GTYHVRLEVNNTVSGAAAQA-DVRVFEELRGLSVDMS LAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLS-GPEATVEHVYLRAQNCTVTVGAASPAGHLAQSLHVLVFVLEVLRI EPAACIPTQPHARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVN---RAHYFTSICV EPEVGNVTLQPERQFVQLGDEARLVACAWP--PFPYRYTWDFGTEEAGPARAGGPEVTCIYRDPGSYLVTVTASNNISAA NDSALVEVQEPVLVTSIKVNGSL--GLELQQPYLFSVVGRGRPASYVWDLGDGGRLEG-PEVTHAYNSTGDFTVRVAGWN EVSHSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV TAENEVGSAQDSIFVYVLQLIEGLQVVGGG-------------RYFPTNHTVQLQAVVRDGTNISYSWTAWRDR-G--PA LAGSGKGFSLTALEAGTYHVRLRATNMLGSAWADCTVDFVEPVGWLMVAASPNPAAVNTSVTLCAELAGGSGVVYTWSLE -EGLSWETTEPFTTHSFPTPGLHLVTMTAGNPLGSANATMEVDVQVPVSGLSIRAS-EPGGSFVAAGSSVPFWGQLATGT NVSWCWVVP-----GGS-SKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTVEEPIVGLVLWASSKVVAPGQPVHF QILLAAGSAVTFRLQVGG--ASPEVLP-GPRFSHSFPRVGDHVVSVQGKNHVSWAQAQVRIVVLEAVSGLQVPNCCESGI ATGTERNFTARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQY VALRSGP--CFTNRSAQFEATTSPSPRRVAYHWDFGDGSP-GQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVT VQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPAR-------------VALP GVDVSRPQLVLPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAPERLVPIIEGGSYRVWSDTQDLVLDGSESYDPNLE DGDQTPLSFHWACVASTQREAGG--------CALNFGP---RGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTV LIRSGRVPIVSLECVSCKAQA--VYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLR RGVLRDGEGYTFTLSVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLG--------------AVHALTTKVHFE-----C TGWYDAEDAGAPLVYALLLRRCR--QGHCEEFCVYKGSLSSYEAVLPPGFRP----HFEVGLAVVVQDQLGAAVVALNRS LAITLPEPNGSATG----LTVWLHGLTASVLPGLLRQANPQHVIEYSLALVTVLNE----YEQALEVAAEPKHERQRRAQ IRKNITETLVSLRVHTVD---DIQQIAAALAQCMT--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -RDPAGSYHLNLSSHFR----W-----SALEVSVGLYTSLCQYFSEEDVVWRTEALL----------------------- ----PLEETSP---------------------RQAVCLTRHLTAFGAS--LFVPRSHVRFVFPEPTVDVNYIVMLTCAVC LVTYMVMAAIVHKLDQLDASR-GHAIPFCGQ----WGRFKYEILVKTGWGRGS--------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------SSTPG EKTETVA--LQRLGELGPP------SPGLNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVG --ASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSL----------------VAKRLHPDEDDTLVESP-AVTP VS---------------------ARVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDAS---- -CHGHAY--RLQSAIKQELHS----------RAFLAITRSEELWPWMAHVLLP-YVHGN----------QSSPE-----L GPPRLRQVRLQEALYPDP-----------------PGPRVHTCSAAG-GFSTSDYDVGWG-------------------- ---------SPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFVELTRY SPAVGLHAAVTLRLEFPAAGRALAALSIRPFALRRLSAGLSLPLLTSVC---LLLFALHFAVAEARTWHREG-------- -------------------------------------------------------------RWRVLRLGAWARWLLVALT AATALVRLAQLGAADRQWTRFVRGRPRRFT---------------SFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVR QWSVFGKTLCRALPELLGVT-----LGLVVLGVAYAQLAVLLVSSCVDSLWSVAQALLVLCPGTGLST------------ --LCPAESWQLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRH KVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTS--SSQLDGLS------------------------------- -VSLGRLGTRCEPEP--SRLQAVFEALLTQFD-LNQATEDVYQLEQQLHSLQGRRS------------------------ -------------------------------------------------------------------------SRAPAGP SRGPSPGLRPALPSRLVRASRGVDLATGPS---------------RTPLRAKNKVHPSST-------------------- ------------------------------------------------------------------------------ >Callithrix_jacchus_PKD1 -------------------------------------------------------------------------------- ----------------DVSHNLLQA---LDVGLLANLSALAELDISNNKISTLEEGLFANLFNLSEMSCGSFGGCHWVGP QVPSIPSASQLVRVSSPGRLCCHRCSKAWGWPLLSIVLWDSGCGEEYVACLPDN----SSGTMEAVAFSPAHEGLLEPEA CSAFCFSTGQHLAALSEQGQCLCGAASPN-ASSACLALCSSPLPPPAPACGGPTLLQHVFP-ASSGAALVGPHGPLASGQ PAAFHIAAPLPITAAHWDFGDGSPKVDGAGPV----ALHRYVLPGHYRVTAVLALGAGSALLETNVQVEAVPATLELVCP SLVQSDESLQ--LSVRNRGGSGLEATYSIVALDEEPTR-----VVHPLCPLDTEIFPGNGHCYRLVVEKAAWLQAQEQCR AWAGAALAMVDSPAVQRFLVSQVTR--SLDVWIGFSAVQG----AGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGP TGWCNTDLCSAPHSYVCELRPGGPVQDAENFLVGAPSGDLQGPLI-PLVQQDDLSAP-RQPVEVMVFPVLSLSQEAFLTT AEFGTQELLQPAQLRLQVYRPLST----------AGTPENGSEPESGFRDNR-TQPAPECMPGGCWCPGANVCLPLDASC HSQACANSCM-------SGP-GLPKAPYMLWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVSLQHDAGPG-------- AFLHCPL---ASSSPGLQAPYLSANASAWLPRLPAQLE--------------------------GARA--CPACALRLLV ATEQFTVLLGLRPNPGLQLPGRYEVQAEVDNGVSRHSLSCSFNVVSPVAGLRVIAPAP-HDGRLYVPTNG-SALVLQLDS GANATATARWAGGNVSARFEATCPALVATLVPSCPWETND---------TLFSVIAL---PWLSEGEHVLEVVAENSASR ANLSLQVMAEEPICGLRAMPSPEARVLQGVLVRYSPVV-----DAGSDVVFRWTINDKQSLTFQNIVFNVIYQSSAVFKL SLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPDAS------LLLTAGVLVDSAVEVAFLWTFGDGEQ-ALGHF QPPYDESFPVPDPSVAQVLVEHNVTHTYTA---PGEYILTVLASNAFENLTKQVPVSVRSVLPSVAVGMSDSVLVAGRPV TFYPHPLPAPGGVLYIWDFGDGSPVLMQSQPATNHTYTSR---GTYRVRLEVNNTVSSAVAQA-DLRVFEELRGLSVDMS LAVEQGAPVVVRAAVETGDNVTWTFDMGDGTVLS-GPEATVEHVYLQAQNCTVTVGAASPAGRLAQSLHVLVFVLEVLRI EPATCIPTQPDARLKAYVTGDPAHYLFDWTFGDGSSNRTVQGCPEVTHNFTQSGTFPLALVLSSRVN---KAHYFTSICV EPEVGNVTLRPEKQFLQLGVAARLVACVWP--PFPYHYAWDFGTEEATSARAAGPRVTFTYRDPGSYLVTVTVSNNVSAA NDSALVEVQEPVVVTDIEVNGSL--VLELQQPYLFSAVGRGRPASYLWDLGDGGQLEG-PEVTHTYNSTGDFTVRVAGWN EVSRSEAWLNVTVKRRVRGLVINASRTVVPLNGSVSFSTLLEAGSDVRYSWVLCDRCTPIPGGPTMSYTFRSVGTFNVIV TAENEVGSAQDSIFIYVLQLIEGLQVVGGG-------------GYFPTNHTVQLQAVVRDGTNISYSWAAQREG-G--PA LAGSGRAFSLTTLEASTYHVQLRATNMLGSAWADCTVVFVEPVGWLMVAASPNPAAINMSVTLSAELAGGSSVLYTWSLE -EGLSWETPEPFTTHSFPMPGLHLVTVTAGNPLGSANATMEVAVQVPVSGLSIRAS-EPSGSFVAAGSSVPFWGQLATGT DVSWCWAVP-----GGG-SKYGPHVTMVFPEAGAFSLRLNASNAISWVSTTHNLTVEEPVVGLVLWASSKVVAPGQLVHF QILLAAGSAVTFRLQVGG--AGPEVLS-GPRFSRSFPHVGDHVVSVQGENHVSWAQAQVRIVVLEAVSGLQVPNCCEQGI ATGTERNFTARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDTIQY VALRSSP--CFTNRSAQFEATTSPSPRRVAYHWDFGDGAP-GWDTDEPRAEHTYLRPGDYRVQVNASNLVSFFMAQATVT VQVLACREPEVDVALPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRIAR-------------MALP GVDVSRPQLVLPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAPERLVPIVEGGSYRVWSDTQDLVLDGSESYDPNLE DGDQTPLSFHWACVASTQREAGG--------CALNFGP---RGSSMVTIPRERLTAGVEYTFSLTVWKAGRKEEATNQTV LIRSGRVPIVSLECVSCKAQA--VYEVSRSSYVYLEGRCLNCSSGSKQGRWAARTFSNKTLVLDETTTSTGSAGMQLVLR RGVLRDGEGYTFTLTVLGHSGEEEGCASIRLSPNRPPLGGSCRLFPLG--------------AVHALTTKVYFE-----C SGWQDAEDSSAPLVYALLLRRCR--QGHCEEFCVYKGSLSSYGAVLPPGFRP----HFEVGLAVVVQDQLGAAVVALNRS LAIVLPEPNSSAAG----LTAWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEAI--YEQAPDTAAEPEHERQRRAQ IRKNITETLVSLRVHTVD---DIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMRILQAETTAGTVTPTAIGDSILN ITGDLIHLASSDVQGP--------------------------QPSELGAEPPSRMVASRAYNLTSALMRILMRSRVLNEE PLTLAGEEIVAQGKRSDPGSLLCYGSAPGPG---CHFSIPEAFSGALS----------NLSDVVQLIFLVDS--NPFP-F GYISNYTVSTKVASMAFQTQAGTQIPIERLASERAITVKVPNNSDWAALGHHSP-------AHSVVVQPQTSVGAVVTLD SSNPAAGLHLQLNYTLLDG-----RYLSEEPEPYLAVYLHSEPRPNQH-NCSASRKIRPESLEG---TDHRPYTFFIAPG NGDPAGSYYLNLTSHFH----W-----SVLEVSVGLYTSLCQYFSEEDMAWRTEGLL----------------------- ----PLEETSP---------------------QQAVCLTRHLTAFGAS--LFVPPSRVHFMPPEPTVGVNYIVLLTCTVC LVTYAVMAAILHKLDQLDASR-GRAIPFCGQ----RGRFKYEILVKTGWGRGSGTTAHV--G-----IMLYG-VDSQSGH RHLDGDRA---FHRN-----------SLDIFQIATLHSLGSVWKIRVWHDNKGLSP----AWFLQHVIVRDLQTARS--- ----------AFFLVNDWLSVETEANGGLVEKEVLAASDMALWSFRRLLVAELQRGFFDKHIWLSIWDRPP--------- -----RSRFTRIQRATCCVLLICLFLGANAVCYGTVGDSAYSTGHVSRLSPLSVDTVAIG-------------------- ---------------LVSSVVVYPIYLAVLFLFRMSRSKVAVGPSPTPA-GQQMLDIDSCLGSSVLDSSFLTFSGLHAEQ AFAGQMK---------SDLFLDDSKSLVCWPSSEGTLSWPGRFSDPSIVGSN---------------------------- -----RQLARGRAGHGLGPE-------EDSLSLASPYSPAKS-------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >Mus_musculus_PKD1 ------------------------MPLGAPALLALALGLGLWLGALAGDPGRGCGPCPLPCFCGPAPDAACRVNCSGRWL QTLGPSLRIPADATALDLSHNLLQT---LDIGLLVNLSALVELDLSNNRISTLEEGVFANLFNLSEINLSGNPFECNCGL AWLPRWAKEHQVHVVQSEATTCRGPIPLAGQPLLSIPLLDNACGEEYVACLPDN----SSGAVAAVPFYFAHEGPLETEA CSAFCFSAGEGLAALSEQNQCLCGAGQASNSSAACSSWCSSISLSLNSACGGPTLLQHTFP-ASPGATLVGPHGPLASGQ PADFHITSSLPISSTRWNFGDGSPEVDMASPA----ATHFYVLPGSYHMTVVLALGAGSALLETEVQVEATPTVLELVCP SFVHSNESLE--LGIRHRGGSALEVTYSILALDKEPAQ-----VVHPLCPLDTEIFPGNGHCYRLVAEKAPWLQAQEQCR TWAGAALAMVDSPAIQHFLVSKVTR--SLDVWIGFSSVEGTE---GLDPRGEAFSLESCQNWLPGEPHPATAEHCVRLGP AGQCNTDLCSAPHSYVCELRPGGPVWDTENFVMGMSGGGLSGPLH-PLAQQETVQGP-LRPVEVMVFPGLSPSREAFLTA AEFSTQKLEEPAQMRLQVYRPSGG----------AAAVPEG----SSEPDNR-TEPAPKCVPEELWCPGANVCIPFDASC NSHVCINGSV-------SRL-GLSRASYTLWKEFFFSVPAGPPTQYLVTLHSQDVPMLPGDLIGLQHDAGPG-------- TLLQCPL---ASSCPG-QALYLSTNASDWMTNLPVHLE--------------------------EAWA--GPVCSLQLLL VTERLTPLLGLGPNPGLQHPGHYEVRATVGNSVSRQNLSCSFSVVSPIAGLRVIHPIP-LDGHIYVPTNG-SVLVLQVDS GANATATAQWFGGNISAPFEDACPPEVDFLKQDCTEEANG---------TLFSVLML---PRLKEGDHTVEIVAQNGASQ ANLSLRVTAEEPICGLRAVPSPEARVLQGILVRYSPMV-----EAGSDVAFRWTIDDKQSLTFHNTVFNVIYQSAAIFKL SLTASNHVSNITVNYNVTVERMNKMHGLWVSAVPTVLPPNAT------LALTGGVLVDSAVEVAFLWNFGDGEQ-VLRQF KPPYDESFQVPDPTVAQVLVEHNTTHIYTT---PGEYNLTVLVSNTYENLTQQVTVSVRTVLPNVAIGMSSNVLVAGQPI TFSPYPLPSTDGVLYTWDFGDGSPVLIQSQPVLNHTYSMT---GAYRITLEVNNTVSSVTAHA-DIRVFQELHGLTVYLS PSVEQGAPMVVSASVESGDNITWTFDMGDGTVFT-GPEATVQHVYLRAQNFTVTVEAANPAGHLSQSLHVQVFVLEVLHI EPSTCIPTQPSAQLMAHVTGDPVHYLFDWTFGDGSSNVTVHGHPSVTHNFTRSGIFPLALVLSSHVN---KAHYFTSICV EPEIRNITLQPERQFVKLGDEARLVAYSWP--PFPYRYTWDFGTEDTTHTQTGGSEVKFIYREPGSYLVIVTVSNNISST NDSAFVEVQEPVLVTGIRINGSH--VLELQQPYLLSAMGSGSPATYLWELGDGSQSEG-PEVTHIYSSTGDFTVRVSGWN EVSRSEAQLNITVKQRVRGLTINASRTVVPLNGSVSFSTLLEVGSDVHYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV TAENEVGSAQDSIFIYVLQFIEGLQVAGGDN--G---------CCFPTNYTLQLQAAVRDGTNISYSWTAQQEGSL--IT LFGSGKCFSLTSLKASTYYVHLRATNMLGSAAANRTIDFVEPVESLILSASPNPAAVNMSLTLCAELAGGSGVVYTWYLE -EGLSWKTSMPSTTHTFAAPGLHLVRVTAENQLGSVNATVEVAIQVPVGGLSIRTS-EPDSIFVAAGSTLPFWGQLAEGT NVTWCWTLP-----GG--SKDSQYIAVRFSTAGSFSLQLNASNAVSWVSAMYNLTVEEPIVNLMLWASSKVVAPGQPVHF EILLAAGSALTFRLQVGG--SVPEVLP-SPHFSHSFFRVGDHLVNVQAENHVSHAQAQVRILVLEAVVGLQVPNCCEPGM ATGTEKNFTARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGLLEIHVRAFNELGGVNLTLMVEVQDIIQY VTLQSGR--CFTNRSARFEAATSPSPRRVTYHWDFGDGTP-VQKTEEFWADHYYLRPGDYHVEVNATNLVSFFVAQATVT VQVLACREPEVEVALPLQVLMRRSQRNYLEAHVDLRNCVSYQTEYRWEIYRTASCQRPGRMAQ-------------MVLP GVDVSRPQLVVPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAAERLVPIIEGGSYRVWSDTQDLVLDGSKSYDPNLE DGDQTPLNFHWACVASTQSETGG--------CVLNFGP---RGSSVVTIPLERLEAGVEYTFNLIVWKAGRKEEATNQTV LIRSGRVPIVSLECVSCKAQA--VYEVSRSSYVYLEGHCHNCSRGYKQGCWAARTFSNKTLVLNETTTSTGSTGMNLVVR PGALRDGEGYIFTLTVLGHSGEEEGCASIRLSPNRPPLGGSCRLFPLD--------------SVRGLTTKVHFE-----C TGWRDAEDGGAPLVYALLLKRCR--QSYCENFCIYKGSLSTYGAVLPPGFQP----LFVVSLAVVVQDQLGAAVVALNRS LTIVLPEPSGNPAD----LVPWLHSLTASVLPGLLKQADPQHVIEYSLALITVLNEY----EQAPD-VSEPNVEQQLRAQ MRKNITETLISLRVNTVD---DIQQITAALAQCMVSSRELMCRSCLKKMLQKLEGMMRILQAETTEGTLTPTTIADSILN ITGDLIHLASLDMQGP--------------------------QPLELGVEPPSLMVASKAYNLSSALMRILMRSRVLNEE PLTLAGEEIVALGKRSDPLSLLCYGKALGPS---CHFSIPEAFSGALS----------NLSDVVQLIFLVDS--NPFP-F GYISNYTVSTKVASMAFQTQTGTQIPIEQLAAERAITVKVPNNSDQAAQSSHNP-------VGSTIVQPQTSVSAVVTAD NSNPQAGLHLRITYTVLNE-----RYLSAEPEPYLAVYLHSVSQPNEY-NCSASRRISLEVLEG---ADHRLYTFFIAPG TGTLDRSYYLNLTSHFH----W-----SALEVSVGLYTSLCQYFSEEMMMWRTEGIV----------------------- ----PLEETSP---------------------SQAVCLTRHLTAFGAS--LFVPPSHVQFIFPEPSASINYIVLLTCVIC LVTYVVMAMILRKLDQLDVSR-VRVIPFCGK----GGRFKYEILVKTGWSRGSGTTAHV--G-----IMLYG-EDNRSGH RHLDGDRA---FHRN-----------SLDIFQIATPHSLGSVWKIRVWHDNKGLSP----AWFLQHIIVRDLQSARS--- ----------TFFLVNDWLSVETEANGGLVEKEVLAANEAALWQFQRLLVAELQRGFFDKHIWLSIWDRPP--------- -----RSRFTRVQRVTCCVLLLCLFLAANAVWYGVVRDTTYSMGPVSSLISPGVDTVAIG-------------------- ---------------LVSSVVVYPVYLAVLFLFRMSRSKVSGDQNPTPT-GQQALDVDSYLDPSVLDSSLLTLSGLTEA- -FAGQVK---------NDLFLEDAKSLVCWPSSEGTLSWPDLLSDPSVVSST---------------------------- ----LQRLTQGRPGCMLGSE-------EDGASLVSPSLPAKYLSASDEDLIHQVLADGANNLVPTQDT------------ -------------------------------------------------------------------------------- -----------------------------------------------------------------LLETDLLTSLSSVPG EKTETLI--LQTVGEERPA------SMGLSWEQSPVTRLSRTGLVEGFQKRLLPAWCAPLAHGLSLLLVAVAVAVSGWIG --ASFPPSVSVMWLLSSSSSFLASFLGWEPLKVLLEALYFSL----------------VAKRLHPDEDDTLVESP-AVTP VS---------------------ERVPRVRPPHGFALFLAKEEARKVKRLHDMLKRLLVYMLFLLVTLLANYGDAS---- -CHGHAY--RLQSAIKQELDS----------QAFLAITRSDEFWPWMSHVFLP-YVHGN----------QSSPE-----L GPPRLRQVRLQEAFCPDP-----------------SSSE-HMCSAAG-SLSTSDYGIGWQS------------------- ---------VVQNGSETWAYSAPDLLGAWYWGYCAVYDSGGYIQELGLSLEESRARLGFLQLHNWLDSRSRAVFVELTRY SPAVGLHAAVTLRLEFPVAGHALAAFSVRPFALRRLSTGLSLPLLTSVC---LLLFALYFSMAEVQTWRKDG-------- -------------------------------------------------------------CACTARPDTWARCLLVILT AATGLVRLAQLGIADRQWTHFVQDHPRHFT---------------SFDQVAQLGSVARGLAASLLFLLLVKAAQQLRFVR QWSVFGKTLCRALPELMGAT-----LGLVLLGVAYAQMAILLISSGADTLYNMARAFLVLCPGARVPT------------ --LCPSESWYLSPLLCVGLWALRVWGALRLGAILLRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRH KVRFEGMDPLPSRSSRGSKSSPVVLPPSSGSEASHPSTS--SSQPDGPS------------------------------- -ASLSRSTLKLEPEP--SRLHAVFESLLVQFDRLNQATEDVYQLEQQLQSLQGHGH------------------------ -------------------------------------------------------------------------NGPPSSP SPGCFPGSQPALPSRLSRASQGLDQTVGPN---------------RVSLWPNNKVHPSST-------------------- ------------------------------------------------------------------------------ >Rattus_norvegicus_PKD1 ------------------------MPPGAPARLALALGLGLWLGALAGDPGRGCGPCPLPCFCSPAPDAACRVNCSGRWL QTLGPSLRIPADATALDLSHNLLQT---LDIRLLVNLSGLVELDLSNNRISTLEEGVFANLFNLSEINLSGNPFECNCGL AWLPRWAKEQQVHVVQSEATTCRGPVPLAGRPLLSTPLLDNACGEEYVACLPDN----SSGAVAAVPFFFAHQGPLETAA CSAFCFSAGEGLAALSEQNQCLCGAGQPSNTSAACSSWCSSILLSFNSACGGPTLLQHTFP-ASPGAALVGPHGPLASGQ PADFHINSPLPISSTCWNFGDGSPEVDMAGPA----ATHSYVLPGGYHVTVVLTLGAGSALLETEVQVEVAPTVLELVCP SFVHSDESLD--LGIRHRGGSALEVTYSILALDKEPAQ-----VVHPLCPSDTEIFPGNGHCYRLVAEKAPWLQAQEQCR TWAGAALAMVDSPAIQHFLVSKVTR--SLDVWIGFSSVEGKE---GLDPQGEAFSLESCQNWLPGEPHPATEEHCVRLGP AGQCNTDLCSAPHSYVCELRPGGPVGDADNFLLGVSGGGRSGPLQ-PLAQQGTLQGP-LQPVEVMVFPGLSPSQEAFLTA AEFETQELEDPVQLRLQVYRHSR-----------EAVAPEG----SSELDNS-TEPAPKCVPEELWCPGANVCVPFDALC NSHVCINGSA-------SRL-GLPRASYTLWKEFFFSVPAGPPTQYLVTLHGQDVPMLPGDLVALQHDAGPG-------- TFLHCPL---ASSCPG-QALYLSTNASDWMTNLPVHLE--------------------------EAWA--GPVCSLQLLL VTEQLTPLLGLGSNPGLQHPGHYEVRATVGNSISRQNLSCSFSVVSPVAGLRVIHPIP-LDGHIYVPTNG-SILVLQVDS GANATATAHWFGGNVSAPFEDACPPEVDFLKQDCTEEANG---------TLFSVLVL---PRLKEGDHTVEIVAQNGASQ ANLSLRVTAEEPICGLRAVPSPEARVLQGILVRYSPMV-----EAGSDVAFRWTIDDKQSLTFHNTVFNVIYQTAAVFKL SLTASNHVSNITVNYNVTVERMNKMHGLWVSAVPAVLPPNAT------LALTGGVLVDSAVEVAFLWNFGDGEQ-VLRQF KPPYDESFQVPDPTVAQVLVEHNTTHIYNT---PGEYNLTVTVSNTYENLTQQVPVSVRTVLPNVTIGMSSNVLLAGQPI TFFPYPLPSADGVLYTWDFGDGSPVLIQSQPVLNHTYSMT---GTYRISLEVNNTVSSVAAHV-DICVFQELHGLTVYLN QSVEQGAPMVVNASVESGDNITWTFDMGDGTVFT-GPEATVEHVYLRAQNFTVTVGATSPAGHLSQSLHVQVFVLEVLRI EPSTCIPTQPSAQIMAHVTGDPAHYLFDWTFGDGSSNVTVHGHPSVTHNFTRSGIFPLALVLSSHVN---KAHYFTSICV EPEICNVTLQPERQVVKLGDEAWLVAYPWP--PFPYRYTWDFGTEDSIHTQTGGSEVTFIYREPGSYLVIVTVSNNISST NDSAFVDVQEPVSVTGIRINGSH--VLELQQPYLFSAMGNGSPAAYLWELGDGSQHEG-PEVTHIYSSTGDFTVRVSGWN EVSRSEAQLNITVKQRVRGLTINASRTVVPLNGSVSFSTLLEVGSDVHYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV TAENEVGSAQDSIFIYVLQLIEGLQVVGGDG--G---------CCFPTNYTLQLQAAVRDGTNISYSWTAQQDG-G--PT LISSGKSFSLTALKASTYYVHLRATNMLGSASANRTIDFVEPVESLILSASPNPAAVNTSLTLGAELAGGSGVVYTWYLE -EGLSRETSMPSTTHTFAAPGLHLVRVTAENQLGSVNATIEVAVQAPVGGLSIRTS-EPDSIFVAAGSTVPFWGQLAEGT NVTWCWTLP-----GG--SKYSQYIDVRFPAAGHFSLWLNASNAVSWVSAVYNLTVEEPIMNLVLWASSKVVAPGQPVHF QILLAAGSAVTFRLQVGG--SIPEVLP-SLHFSHSFFRVGDHMVSVQAENHVSRAQAQVRILVLEAIVGLQVPNCCEPGM ATGTEKNFTARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGILEIHVRAFNELGGVNLTLVVEVQDIIQY VTLQSGR--CFTNRSARFEAATSPSPRRVTYHWDFGDGTP-VQETEESWTDHYYLHPGDYRVEVNATNLVSFFVAQATVT VQVLACREPEVEVALPLQVLMRRSQRNYLEAHVDLRNCVSYQTEYRWEVYRTTSCQRPGRMTQ-------------MVLP GVDVSRPQLVVPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAAERLVPIIEGGSYRVWSDTQDLVLDGSKSYDPNLE DGDQTPLNFHWACVASTQSETGG--------CVLNFGP---RGSSVVTIPLERLEAGVEYTFNLIVWKAGRKEEATNQTV LIRSGRVPIVSLECVSCKAQA--VYEVSRSSYVYLEGHCHNCSSGSKQGRWAARTFSNKTLMLNENTTSTGSTGMHLVVR PGALHDGEGYIFTLTVLGHSGEEEGCASIRLLPNRPPLGGSCRLFPLE--------------SVRGLTTKVHFE-----C TGWRDAEDGGAPLVYALRLKRCH--QNYCEDFCIYKGSLSTYGAVLPPGFQP----LFVVSLTVVVEDQLGASVVALNRS LTIVLPEPSGNPAD----LIPWLHSLTASVLPGLLRQADPQHVIEYSLALITVLNEY----EQAPDMVSEPNLEQQLRAQ MRKNITETLISLRVNTVD---DIQQITAALAQCMVSSRELMCRSCLKKMLQKLEGMMRILQAETTEGTLTPTTIADSILN ITGDLIHLASLDMQGP--------------------------QPLELGAEPPSLMVASKAYNLSSALMCILMRSRVLNEE PLTLAGEEIVALGKRADPLSLLCYGKAWGPS---CHFSIPEAFSGALS----------DLSDVVQLILLVDS--NPFP-F GYISNYTVSTKVASMAFQTQTGTQIPIEQLAAERAITVKVPNNSDQAAQSSHSP-------VGSTIVQPRASVSAVVTAD NSNPQAGLHLRITYTVLNA-----RYLSEEREPYLAVYLHSVSQPNEY-NCSASRRISLEVLEG---ADHRPYTFFIAPG TGTLGRSYYLNLTSHFH----W-----SALEVSVGLYTSLCQYFSEEAMMWRTEGIV----------------------- ----PLEETSP---------------------SQAVCLTRHLTAFGAS--LFVPPSHVQFIFPEPSVSINYIVLLTCVIC LVTYVIMAMILRKLDQLDVSR-VRVIPFCGK----GGRFKYEILVKTGWSRGSGTTAHV--G-----IMLYG-EDNRSGH RHLDGDRA---FHRN-----------SLDIFQIATPQSLGSVWKIRVWHDNKGLSP----AWFLQHIIVRDLQSARS--- ----------TFFLVNDWLSVETEANGGLVEKEVLAANEAALWQFQRLLVAELQRGFFDKHIWLSIWDRPP--------- -----RSRFTRVQRVTCCVLLLCLFLAANAVWYGVVGDTTYSMGPVSSLMSPSVDTVAIG-------------------- ---------------LVSSVVVYPVYLAVLFLFRMSRSKVSGDQNPTPT-GQQALDVDSYLDPSVLDSSLLTLSGLTEA- -FSGQVK---------NDLFLEDAKSLVCWPSSEGTLSWPDLLSDPSVMSST---------------------------- ----LQRLAQGRPGCMLGSE-------EDGASLVSPSLPAKYLSASDEDLIHQVLADGANNPDPTQDA------------ -------------------------------------------------------------------------------- -----------------------------------------------------------------LIERDLLTSLSSAPG EKTETLI--LQTMGEKRPP------SMGLTWEQSPVTRLSRTGLVEGLRKRLLPTWCAPLAHGLSLLLVAVAVAVSGWIG --ASFPPSVSVMWLLSSSSSFLASFLGWEPLKVLLEALYFSL----------------VAKRLHPDEDDTLVESP-AVTP VS---------------------ERVPRVRPPHGFALFLAKEEARKVKRLHDMLKSLLVYMLFLLVTLLANYGDAS---- -CHGHAY--RLQSAIKQELDS----------QAFLAITRSDEFWPWMSHVLLP-YVHGN----------QSSPE-----L GPPRLRQVRLQEAFCPDP-----------------SSSE-HMCSATG-SLSTSDYGIGWQS------------------- ---------VVQNGSETWAYSAPDLLGAWYWGYCAVYDSGGYIQELGLSLEESRARLGFLQLHNWLDSRWVLMFVELTRY SPAVGLHAAVTLRLEFPVAGHALAAFSVRPFALRRLSTGLSLPLLTSVC---LLLFALYFSVAEVHTWRREG-------- -------------------------------------------------------------CARTARPEAWARWLLVMLT AATGLVRLAQLGIADRQWTRFVHDHPHHFT---------------SFDQVAQLGSVARGLAASLLFLLLVKAAQQLRFVR QWSVFGKTLCRALPELMGAT-----LGLVLLGVAYAQMAILLISSGADTLYSMARAFLVLCPGARVPT------------ --LCPSESWYLSPLLCVGLWALRVWGALRLGAVLLRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRH KVRFEGMDPLPSRSSRGSKSSPVVPPPSAGSEASHPSTS--SSQPDGLS------------------------------- -AGLGRSALRLEPEP--SRLHAVFESLLVQFDRLNQATEDVYQLEQQLQSLRGHGH------------------------ -------------------------------------------------------------------------SGPPSSP SPGGFPASQPALPSRLARASQGPDQTTGPS---------------RVSLWPNNKVHPSST-------------------- ------------------------------------------------------------------------------ >Canis_familiaris_PKD1 -------------------------------------------------------------------------------- ----------------DVSHNLLRA---LDVGLLANLSALTELDISNNKISTLEEGIFSNLFNLSEINLSGNPLECDCGL AWLPRWAEEQQVHVVRPEAATCAGPGPLAGQPLLGVPLLDGGCGEEYIACLPDN----SSGAVALVAFSAAHEGPLTPEA CGAFCFAAGNGLGAFSDQGWCLCGAAQPPNTSSACLPFCSGAPLALAPACGGPTLLQNIFP-ASPGAALVGPQGPLASGQ PAAFHVTASLPVSSTRWDFGDGSPKVDIAGPA----TTHRYLLPGLYHVTVVLALGAGSAQVETQVHVEAAPASLELTCL TSVRSDETLK--FGIRNRGGSDLEATYSIVAVGEEPAQAADPAVVHPLCPSDTVIFPGNGHCYRLVAEKAAWLQAQEQCR AWAGAALAMVDSPAIQHFLVSQVTR--SLDVWIGFSAVEGAE--AGPVVQGAAFSLESCQNWLPGEPHPATAERCVRLGP AGQCNTDLCSAPHSYVCELRPGGPVWDAENFLVGAPIGDLQGPLS-PLAQQEALSAP-QELIEVMVFPSLGLSREAFLTA AEFGTQELRRPTQLRLQVFRPVGE----------AGAPGNSREPESGSRESR-TESVPECTPEGRWCPRASIHLPPDDPC GPWACANGSM-------SGP-GLPGASCVLLREFLFSVPAGPPSQYSVTFRGQDGPLKPGDLIALQHDAGPG-------- ALLCCSP---ALGAPGAEAPYFSATSPAWLVHLPAQLE--------------------------AAPA--GPACALRLLV ATERLTTLLGLRPNPGLRRPGRYEVRATVGNSVSTHNLSCSFDVLSPVAGLRVAHPIP-HDGRLYVPTNS-SVLVLQVDS GTNATATARWPGGNASAPFEATCPATVAALVPSCTLEAND---------TLFAVLVL---PGLSEGEHAVEIMVENSAGH ANLSLRVKAEEPICGLRAAPSPEARVLQGVLVRYSPVV-----EAGSDVVFRWTIDDKQSLTFPHVVFNVIYQSAAVFSS RLTASNHVSNVTVNYNVTVERMHKMKGLRVSAVPPVLPPNTT------LELAAHVLVDSAVEVAFLWTFGDGDQ-VLGQF KPPYNESW-VPDPTVAQVLVEHSVTHVYAV---PGEYNLTLLVSNAFENLTQQVPVSVRATLPAVAVAVGSHVLVAGQPV TFSPHPLPSPGGILYTWDFGDGSPAVTQHQTEVSHTYASR---GIYRIHLEVNNTVSSVTAWT-SVRVFEELRGLSVSLS PSVEQGAPVTVSATLESGDNVTWTFDMGDGTVLV-GPEAMVEHVYLRAQNHTVTVGVSSPAGYLALSLPVHVFVLEVLRI EPAACIPVQPHTWFMAHVTGDPAHYIFDWTFGDGSSNTTIFGDPTVTHNFTRSGTFPLALVLSSHVN---KAHYFTSVCV EPEVGNVTLWPERQFVRLGDEAHLVARAWP--PFPYRYTWDFGPEDAP--RVGGPEATFTYADPGSYLVTVAVSNNISAA NDSALVEVEEPVELTGIGVNGSG--VLELQRPYLFSAVGRGHPATYLWELGDGGRLEG-PSIKHTYNSTGHFTVRVSAWN EVSRGEAWLNITVQRRVQGLSVNASRTVVPLNGSVSFTTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV TAENEVGSAQDSIFIYVLRHIEGLQVAGGGG--G---------CCFPTNCTLQLQAVVSDGTNISYSWSAQRDG-G--PA LAGSGKAFSLTVLEAGTYHVQLRAANMLGTSWANRTVDFVEPVGALAAAASPNPAIVNSSVTLCAELAGGSGVTYTWSPE -GGLSWETPEPSSTHVFPSPGLYLVRVTATNWLGSANVTIEVAVQVPVSGLSIRAG-DIDRGFVAAGSAVPFWGQLDSGT NVSWCWTVP-----GG--SRRGQHVAVVFRDAGAFSVRLNASNAVSWVTATRELTVEEPIAGLVVWADSKVVEPGQLVHF QVMLAAGSAVRFHLQVSG--AAVEALP-GPRFSRSFPRVGDYMVSVQAENHVSRAQAQVRILVLEAVGGLQVPHCCELGI PTGTERNFTARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGLLEIHVRAFNDLGGVNLTLLMEVQDAIQH VVLRSGR--CFTNRTARFEAATSPSPRRVAYRWDFGDGAV-VEDTEEPWAEHSYLRPGDYRIEVNASNLVSFFVAQATVT VHVLACREPEVDVALPPQVLMRRSQRNYLEAHVNLRDCVTYQTEYRWQVYRAASCQRPGRLAP-------------VALP SVDMSRPQLVVPRLALPVGHYCFVFMVSFGDTPLARSIQANVTVVPERLVPIVEGGSYRVWSDTQDLVLDGSKSYDPNLE DGDQTPLSFHWACVASTQSETGG--------CTLTFGP---RGSSVVIVPRERLQAGVEYTFNLTVWKAGRKEEATNQTV LIRRGRVPIVSLECVSCKAQS--VYAVSRKSYVY-EGRCDNCSEGSKRGRWAARTFSNQTLVLDETTTSTGSSGMRLVLR RGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSANRPPRGGSCRLFPLD--------------AVRALTTKVHFE-----C TGWQDAEDASAPLVYALLLRRCR--QGHCEEFCVYRGSLSAYGAVLPPGFAP----HFQVGLAVVVQDQLGAAVVALNRS LAITLPQPPGDPQGGPTDLTSWLHGLTESMLPRLLRQADPQHVIEYSLALITVLNEASAGSEQVLAVVAEEDARRQLQAQ IRKNVTETLVSLRVNTVD---DIQQIAAALAQCTVSSRELVCHSCLKKTLHKLEAMMRILQAETAAGTGTPTGIADSILN ITGDLIHLASVDMQGL--------------------------QPSELGTEPPSLMVASRAYHLSSALMCILMRSRVLNEE PLTLAGEEIVAQGKRSDPLSLLCQGNASVPS---CHFSIPTAFSGALS----------NLSDVVQLMFLVDS--NPFP-F GYISNYTVSTKVASMAFQTQAGTQIPIGQLASERAIIVKVPNSSDQAAPGHRAP-------AGSAVIQPQASISVAVTPE NSNPAAGLHLQLTYTLLNE-----RYLPEEPEPYLAVYFDSVPGPNEH-NCSASRRISLEELAG---GDHRPYTFFIAPG TRDSGGTYYLNLTSHFH----W-----SALEVSVGLYTSLCQYFSEKEMMWKTEGLV----------------------- ----PLEETSP---------------------SQAVCLTRHLTAFGAS--LFVPPSHVHFIFPEPASGVNYIVLLTCIVC LVTYTVMAVILRKLDQLDVSR-VRIIPFCGK----GGLFKYEILVKTGWGRGSGTTAHV--G-----IMLYG-AEGRSGH RHLDGDRA---FRRN-----------SLDVFQIATPHSLGSVRKIRVWHDNKGLSP----AWFLQHIIVRDLQNARS--- ----------TFFLVNDWLSVETEANGGLVEKEVLAASEAALRRSRRLLVAELQRGFFDKHIWLSIWDRPP--------- -----RSRFTRVQRATCCILLVCLFLGANAVWYGVVGDTASSAGPVSTLIPLSVDTIAVG-------------------- ---------------LVSSVVVYPVYLVILFLFRMSRSKVAGAPSPTPA-GQQVLDVDSYLDSSVLDSSFLTFPGLRTE- AFAGQMK---------SDLFLDDSKSLVCWPSSEGTLNWPDLLSDPSIMGST---------------------------- ----LQRLARGRTGHTLGPE-------DDGLSLLSPSSPAKYFSASDEDLIQQILAEGASSLAPTQDT------------ -------------------------------------------------------------------------------- -----------------------------------------------------------------QVETDLLTSLSSAPG ETTETLT--LQRLGERGPPC-----SSGVTWEQPTSARLSGTGLADGLQKRLLPAWCASLAHGLSLLLAAVAVGVSGWVG --SSFPPGVSVMWLLSSSSSFLASFLGWEPLKVLLEALYFSL----------------VAKRLHPDEDDTLVESP-AVTP VS---------------------ERVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLANHGDAS---- -CHNHAY--RLQSAIKQELGS----------QAFLAITRSDEFWPWMSHVLLP-YIHGN----------QSGPE-----L GPPRLRQVRLQEALCPDP-----------------PGAAVHACSAGQDAFSTGDYSIGWGS------------------- ---------AAQNCSETWAYSAPDLLGIWSWGYCAVYDSGGYVQELGLSLEESRAQLGFLQLHNWIDNRSRAVFVELTRY SPAVGLHAAVTLRLEFPAAGHAVTAVSVRPFPLQRLSTGLSLPLLTSV---SLLLFALYFSVAEVRTWRREG-------- -------------------------------------------------------------CRRAAQPGAWARWLLVALT AAAALVRLAQLGVADRQWARFLRRRPRRFT---------------SFEQVAQLSAAARGLAASLLFLLLVKAAQQLRFVR QWSVFGKTLCRALPELVGAA-----LGLVALAVAYAHLAVLLVSSCVDSFRSAARALLVLCPGSGGPA------------ --LCPAESWRLSPLLCTGLWALRLWGALRLGAVLLRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRH KVRFEGMEPLPSRSSRGSKSSPDAPPPSGGSDTSRPSTS--SSQLDTLS------------------------------- -GGLGRLGPRGEPEP--SRLQAVFEALLTQFDRLNQATEDVYQLEQRLQSLRGRRS------------------------ -------------------------------------------------------------------------TVPPASP PHSPCSALQPALPSRLARASRGMGLASGPS---------------RASLRAKNKVHPSST-------------------- ------------------------------------------------------------------------------ >Felis_catus_PKD1 -------------------------------------------------------------------------------- ----------------DVSHNLLRA---LDAGLLANLSALTELDISNNKISTLEEGLFANLFNLSEINLSGNPLECDCGL AWLPRWVEEQQVRVVRPEAATCAGPGPLAGRPLLGVPLSDSGCGEEYIACLPDN----SSGAVVPVAX------------ -------AGWGLGALSDQGWCLCGAAQPPNASSACLPLCSSPPLPLAPACGGPTLLENVFP-ASPGAALVGPPGPLASGQ PAAFHVTASLPVSSTHWDFGDGSPKVDVAGPA----TTHRYSLPGHYQVTAVLALGAGSAQLGAKVQVEAAPAALELECP VSVLSDETLK--LGVRNRGGSGLEATYSIVSLGEEPGR-----VVHPLCPSDTVIFPGNGHCYRLVAEKAAWLQAQEQCQ AWAGAALAMVDSPAVQRFLVSQVTR--SLDVWIGFSAVEGAE--AGPAVRGEAFSLESCQNWLPGEPHPATAERCVRLGP AGQCNTDLCSVPHSYVCELRPGGPVWDAENFLVGAPPGDLQGPLS-PLAQQEALSAP-QEPVEVMVFPSLGLSREAFLIA AEFGTQELHRPAQLRLQVFRPEGG----------AGAPGHGGEPESASLESQ-ARPVPACTPEGRWCPQTGIPLSPDTLC RPRACANTST-------SGP-GPPGTSCVLWKEFLFSVPAGPPTHYSVPFQGQDGPLLPGDLVTLQHDAGPG-------- ALLHCSP---ALGPPGPEAPYLSAVASAWLAHLPAQLE--------------------------VAPT--GPACALRLLA ATERLTPLLGLRPNPGLRRPGHYEVRATVGNSVSMHNLSCDFDVLSPVAGLRVAHPTP-HDGRLYVPTNG-SVLVLRVDS GTNATATAHWPGGNVSAPFEAAX-------------------------------------------------VVENSAGQ ANLSLQVKAEEPICGLRATPSPEARVLQGVLVRYSPMV-----EAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAVFKL SLTASNHVSNVTVNYNVTVERMNRMRGLWVSAVPPVLPPNAT------LALAAHVLVDSAVEVAFLWTFGDGDQ-VIGQF KPPYSESFRVPDPAVAQVLVEHNVTHAYAI---PGEYNLTLLVSNAFENLTRQVSVSVRATLPAVAVAVGSRVLVAGQSV TFAPRPLPSPGGILYTWDFGDGSPAVTQHRPEVNHTYSSG---GEYRVRLEVNNTVSSVTACV-GIRVFEELRGLSVSLS PSVEQGAPVTVSATLESGDNVTWTFDMGDGTVLT-GPEATVEHVYLRARNCTVTVGASSPAGRLALSLPLQVFVLEVLRI EPAACIPVQPLARLTAHVTGDPTHYIFDWTFGDGSSNTTVSGDPTVTHNFTRSGTFPLTLVLSSHVN---KAHYFTSVCV EPELGNVTLWPERQFVRLGDEARWVARAWP--PFLYRYTWDFGTEDPA--RVGGPEATFAYPASGSYLVTVAVSNNISAA NDSALVEVQEPVELTGVRVNGSR--VLELQQPYLFSAVGRGCPATYLWELGDGGLLEG-SAVTHAYNSTGHFTIRVTGWN EVSRGEARLNVTVRERARGLSVNASRTVVPLNGSVSFTTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV TAENEVGAAQDSIFVYVLQHIEGLQVVGGGG--G---------CCFPTNRTLQLQAVVRDGTNISYSWTAQRDG-G--PA LAGSGRAFSLTVLEAGTYHIQLRAANMLGSALANRTVDFVEPVGWLAAAASPNPAAVDASVTLCAKLAGGSGVIYSWSLE -GGLSWETPEPSTTHTFPTPGLYLVTVTARNQLGSANATTEVAVQVPVSGLSIRAG-ELGGSFVAAGSAVPFWGQLDSGT DVSWCWEVP-----GG--SRHGQHVSVVFRDAGAFSVRLNASNAVSWGLATRELTVEEPVAGLVLWASSKVVAPGQPVHL QVLLAAGSAVSFYLQVGG--AAPEALP-GPRFSRSFPRAGDYTLSVQAENHVSRAQAQVRILVLEAVGGLQVP------- -------------------------------------------------AGLLEIHVRAFNELGGVNRTLVVEVQDTIQH VVLRSGR--CFTNRSARFEAATSPSPRRVAYRWDFGDGAP-AEDTEEPWAEHSYLRPGDYRVEVNASNLVSFFVAQATVT VHVLACREPEVDVALPPQVLMRRSQRNYLEAHVNLRDCVTYQTEYRWEVYRAAGCHRPVRMAP-------------VALP SVDMSRPQLVVPRLALPVGHYCFVFLVSFGDTPLARSIQANVTVVPERLVPIIEGGSYRVWSDTQDLVLDGSKSYDPNLE DGDQTPLSFHWACVASTQSETGG--------CTLAFGP---RGSSVVTVPRERLQAGVEYTFNLTVWKAGRKEEATNQTV LIRRGRVPLVSLECVSCKAQA--VYAVSRSSYVYLEGRCDNCSGGSQRGRWAARTFSNETLVLDETTTSTGSSGMRLVVR RGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSANRPPRGGSCRLFPLD--------------AVRALTTKVHFE-----C TGWQDAEDAGAPLVYALLLRRCR--QGHCEEFCVYRGSLSAYGAVLPPGFAP----HFQVDLAVVVQDQLGAAVVALNRS LAITLPELPSDLPGGPLDLTTWLHSLTESMLPRLLRQADPQHVIEYSLALITVLNEH----EQALASSAESDPRRQLQAQ IRKNVTEILVSLRVNTVD---DIRQIAAALAQCTVSSRELVCRSCLKKTLHKLEGMMHILQAETAEGTGTPTAIADSILN ITGDLIHLASADVQGP--------------------------QPSELGAEPPSLMVASRAYHLSSALMCILMRSRVLNEE PLTLAGEEIVAQGKRSDPLSLLCQGDASVPG---CHFSIPEAFSGALS----------NLSDVVQLIILVDS--NPFP-F GYISNYTVSTKVASMAFQTQAGAQIPIGRLASERAITVKVPNNSDQAARGCRTP-------AGSAVVQPQASVGVVVVPE DNNPDAGLHLQLTYSVLSE-----HYLSREPEPYLAVYLHSVPQPNEH-NCSASRRIGPEALAG---RDHRPYTFFIAPG SRDPGGTYYLNLTSHFR----W-----SALEVTVGLYTSLCQYFSEKDMMWRTEGLV----------------------- ----PLEETSP---------------------SQAVCLTRHLTAFGAS--LFVPPSHVRFIFPEPASGVNYVVLLTCSVC LVTYVVMAVILRKLDQLDVSR-VRVIPFCGK----GGRFKYEILVKTGWGRGSGTTAHV--G-----IMLYG-AEGRSGH RHLDGDRA---FRRN-----------SLDVFQIATPHSLGSVRKIRVWHDNKGLSP----AWFLQHIIVRDLQTACS--- ----------TFFLVNDWLSVETEANGGLVEKEVLAASDAAVRRFRRLLVAELQRGFFDKHLWLSLWDRPP--------- -----RSRFTRVQRATCCVLLVCLFLGANAVWYGVVGDAAYSAGPVSGLIPLSADTVAVG-------------------- ---------------LVSSVVVYPVYLVILFLFRMSRSKVAGGPSPTPA-GQPVLDIDSYLDSSVLDSSFLAFPGLRAE- AFAGQMK---------SDLFLDDCKSLVCWPSSEGTLNWPDLLSDPSIVGST---------------------------- ----LQRLARGR----LGPE-------EDGLSLVSPSSPAKSFSASDEDLIRRIVAEGAGSLAPARDA------------ -------------------------------------------------------------------------------- -----------------------------------------------------------------QIETDLIAGLSSAPA ERTETLM--LQRLGDRGLP------SPGLTWERPQSAKPARTGLVDGLRRRLLPAWCAPLAHGLSLLLVAVAVGVSGWVG --ASFSPGVGVMWLLSSSSSFLASFFGWEPLKVLLEALYFSL----------------VAKRLHPDEDDTLVESP-AVTP VS---------------------ERVPRVRPPHGFALFLAKEEARKVKKLHGMLRSFLVYMLFLLVTLLANHGDAS---- -CHSHAY--RLQSAIKQELGS----------QAFLAITRSEEFWPWMSHVLLP-YIHGN----------QSSPE-----L GPPRLRQVRLQEALCPDP-----------------ARPGVPVCAAAAGSFSTGDYGIGWGS------------------- ---------AAHNGSEMWAYSAPDLLGVWSWGYCAVYDSGGYVQELGLSLEESRAQLGFLQLHNWIDNRSRAVFVELTRY SPAVGLHAAVTLRLEFPVAGHAVTAVSVRPFALRRLN------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------RALPELVGAA-----LGLVVLAVAYAQLAILLVASCVDSFRSALRAVLVPCPGSGGPA------------ --PCPAESWRLSPLLCTGLWALRLWGALRLGAVLLRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRH KVRFEGMEPLPSRSSRGSKSSPDAPPPSGGSDASRPSTA--SSQLDTP-------------------------------- -GGAEPAGPRGEPEP--SRLQAVFEALLTQFDRLNQATEDVYQLEQRLQSLQGRRS------------------------ -------------------------------------------------------------------------TG----- AHSPSSDLRPALPGRLARASRGVGLAPGPC---------------RVSLRAKNKVHPGST-------------------- ------------------------------------------------------------------------------ >Bos_taurus_PKD1 ------------------------MPPAAPARLALALGLGLWLGALAGVPGRGCGPCAPPCLCGPAPGAACLVNCSGQGL RTLGPALRIPADATALDVSHNLLQA---LDIGLLANLSALMELDISNNKISTLEEGIFANLFNLSEVNLGGNPLECDCGL AWLPRWVEGQRVRVVRPEAATCAGPGPLAGQPLLGGALLDGACGEEYVACVPDD----SSGAVALVAFLAAPEGPLAPEA CSALCFEAGQALAALSEQGRCLCGAARPPNASSACLPSCSGPSLPLAPACRGPSLLQHVFP-ASPGATLLGPQGPLASGQ PAVFHVTALLPVSSTHWDFGDGSPEVDVTGPD----ATHRYVLPGRYPVTAVLALGVGSARLGVEVRVEAAPAALELVCV ASVHSEETLQ--LSVRNRGGSGLEAAYSIVALGEEPAQ-----VVHPLCPSDTEIFPGNGHCYSLRAEKASWAQAQEQCR AWAGAALAMVDSPAVQHFLVSRVTR--SLDVWIGFSAVEGAA--AGPAPQGGAFSLESCQNWLPGEPHPATAERCVRLGP AGQCNTDLCSAPHSYVCELRPGGPVWDAENFLVGAPNGDLQGPLS-PLEQQEALLAP-QEPVEVMAFPGLSPSREAFLTA AEFGTQELGRPAQLRLQVYRAGRG----------AGAPGNSSEPQGRSLENR-TELAPVCAPEGPLCPQANVCLPLDTPC HPGACANGSM-------PGP-GLPGVSYVLQKEFLFSVPAGPPAQYSVPFHGQDIALLPGDLVILQHDAGPG-------- TLLRCPP---ALSFPGSEAPYFSANASAWLAHLPAQLE--------------------------AAPA--GPACALRLLA ATERLTPLLGLGPNPGLRRPGRYEVRATVGNSVSRHNLTCIFDVLSPVAGLRAIYPAP-QDGRLYVPTSG-SPLVLQVDS GANATAEARWPGGNASAPFEAACPAAVAALAPGCAQEANG---------SLFSMLTL---PGLREGEHEVEVVVENGAGR ANLSLLVTAEEPIRGLRATPSPEARVLQGVLVRYSPAV-----EAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAVFKL SLTASNHVSSVSAHFNVTVEPMQRMRGLCVSAVPPVLAPNAT------LALAAHVLVDSAVEVAFLWTFGDGQQ-AVGQF KPPY-DSFEVPDPTVAQVLVEHNTSHTYTF---PGEYSLSLLVSTAFENLTQQVPVSVRAALPAVAVAVGSQVLVAGRPV AFFPRPLPSPGGVLYTWDFGDGSPAVTQPQPEVNHTFALR---GTYRVRLEVNNTVSHTVADV-SVRVFEELCGLTVSLS PAVEQGVPTVVSAALDSGDNVTWTFDMGDGTVLT-GPEATVEHVYRRAQNCTVTVSASSPAGHLARSLPVHVFVLEVLWI EPVACIASQPHARLTAHVTGDPAHYVFDWTFGDGSPNVSIQGDPTVTHSFTHSGTFPLALVLSSRVN---RAHYFSSVCV EPELGNVTLQPERQFVRLGDEARLVAHAWP--PFPYRYTWDFGAEDGAT-HVGGPEATFTYQLAGSYLVTVTAANNISAT NDSALVEVQEPMEVTGIRVNSSH--ALELQQPYLFSAVGRGHPASYLWELGDGRQLQG-PTVTHAYSSTGCFQVRVAGWN EVSRGEARLNVTVQRRVRGLSLNASRTVVPLNGSVSFSTVLEAGSDVHYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV TAENEVGAAQDSIFVYVLQHIEGLQVVGGG-------------CCFPTNRTLQLQAVVRDGTNISYSWAAQRDG-G--PT LAGSGKAFSLTVLEAGTYHVQLRATNMLGSASANCTVDFVEPVGWLAVTASPNPAAVNTSVTLWAELAGGSSVIYSWSLE -EGLCWETREPSTTLIFPSPGLCLVTVVAKNQLGSANASVEVVVQVPVGGLSIQAR-ELDGGFVVAGSTVPFWGQLAVGT DVSWRWAVP-----GG--SRQGQHITVVLPDAGPVSIQLNASNAVSWVTATHNLTVQEPIVGLVLWASRKVVEPGQPVHF QILLAAGSAVRFLLQVGG--GGLEVLP-TPHFSRSFPRVGDYTVSVHAENRVSRAQAQVRISVLEAVGGLQVPDCCGPAI ATGAERNFSARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGLLEIHVRAFNELGGVNCTLLVEVQDAIQH VVLRGPR--CFANRSAHFEAATSPSPRRVSYHWDFGDGAP-VEDTEGPWAVHSYLQPGDYPVQVNASNLVSFFVAQATVT VHVLACREPAVDVALPPQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRATSCQRPGRAAR-------------VALP GVDVSRPQLVVPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAPERLVPIVEGGSSRVWSDSQDLVLDGSKSYDPNLE DGDQTPLSFHWACVAATQSETGG--------CALNFGP---RGSSVVTIPRERLRAGVEYTFNLTVWKAGRKEEVTSQTV LVRSGRVPIVSLECVSCKAQA--VYAVSRSSYVYLEGRCDNCDGGLEHGLWAARSFSNETLVLDATTTSTGSTGMRLVVR RGVLRDGEGYTFTLTVLGRSGQEQGCASIRLAPNRPPRGGSCRLFPVE--------------DVRALTTKLHFE-----C TGWQDAEDAGAPLVYALQLRRCR--QGHCEEFCVYKGSLASYGAVLPPGFAP----HFVVGLAVLVQDQLGAAVVALNRS LTITLPDPPGDPADGPLDLMGWLHSLAGSTLPGLLRQADPQHVMEYSLALIAVLNEY----EQTLPVLAEPDPRQELRAQ IRKNITETLVSLRVNTVD---DIQQVAAALAQCTVSSRELVCRSCLKKTLHRLEDMMRILQAETATGAGTPTTIADSILN ITGDLIHVASSDVQGP--------------------------QPSELGAEPPSLLVASRAYQLSSALVGILTRSRVLNEE PLTLAGEEILAQGKRSDPRSLLCQGDVPGPG---CHFSIPEAFSAALP----------NLSDVVQLILLVDS--NPFP-F GYISNYTVSTKVASMAFQTQAGAQIPIRQLASERAITVKVPNNSDQAAQDQYVP-------AGSTVIQPRASVSVVVTPE NSNPEAGLHLQLTFTVLDE-----QYLPDEPEPFLAAYLHSEPRPNEY-NCSASKKISLEALAG---GDHRPYTFFIAPG SRDLGASYHLNLSSHFR----W-----SALAVSVGLYTSLCQYFSEEHMAWRSEGLV----------------------- ----PLEETSP---------------------REAVCLTRHLTAFGAS--LFVPASRIEFTFPEPASGINHVVLLTCAVC LLTYAVMAVILRKLDQLDVRR-VRAIPFCGK----GGRFKYEILVKTGWGRGSGTTAHV--G-----IMLYG-ADGRSGH RHLDGDGA---FQRN-----------SLDVFQIATPHSLGRLWKIRVWHDNKGLSP----AWFLQHVIVRDLQSARS--- ----------TFFLVNDWLSVEMEANGGLVEKEVLAASDAVLWRFQRLLVAELQRGFFDKHVWLSMWDRPP--------- -----RSRFTRVQRATCCVLLVGLFLGANAVWYGAVGDSAHSQGPVSSLAPLSLDTVAVG-------------------- ---------------LVSSLVVYPVYLAILFLFRMSRSKVAGGPSPTPA-GPQALDVDSCLDSSMLDSSMLAFPGLGGE- AFAGQMK---------QDLFLEDSKSLVCWPSSEGTLSWPDLLSDPSVMGSA---------------------------- ----LQRLARGRMGLTPGPE-------EDSLSLVSPSSPAKYFSASDENLIRQILAEGAGSLAPTQDT------------ -------------------------------------------------------------------------------- -----------------------------------------------------------------QGETDLLAGLCSAPG EKTQPAM--LRSLGDTRLP------SPGLTWEQPPPARLPRTGLVEGLRKRLLPAWCAPLAHGLSLLLVAVAMGVSGWVG --ASFPPSVSVMWLLSSGSSFLASFLCWEPLKVLLEALYFAL----------------VAKRLHPDEDDTLVESP-AVTP VS---------------------ERVPRVRPPHGFALFLAKEEARKVKRLHRMLRGLLVYMFFLLVTLLANYGDTS---- -CHNHAY--RLQSAIKQELDS----------QAFLAITRSDEFWPWMSHVLLP-YIHGN----------QSRPE-----L GPPRLRQVRLQEALCPQP-----------------PGSRNPACSAASSGFSTSDYGVGWGS------------------- ---------AALNSSEIWAYSAPDLLGVWSWGSCAVYDSGGYVQELGPSLEESRAQLGFLQLHNWIDNRSRAVFVELTRY SPAVGLHAAVTLRLEFPAAGHAVAALSVRPFALRRLSAGLSLPLLTSVS---LLLFAVYFSVAEVRAWRREG-------- -------------------------------------------------------------RARATRAGTWARWLLVVLT AAAALVRLAQLGAADRQWTRFLRRRPRRFT---------------SFEQVAQLSAVARGLTASLLFLLLVKAAQQLRFVR QWSVFGKTLCRALPELAGAA-----LGLVVLAAAYAQLAVLLVSSCVDSLRSAAQALLVLCPGTGVPA------------ --LCPAESWRLSPMLCTGLWALRLWGALRLGSVLLRWRYHTLRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRH KVRFEGMEPLPSRSSRDSKASPDVPPPSGGSDASRPSTS--SSQLEGLS------------------------------- -LGLGRPGPR-ELEPEPSRLHAVFEALLTQFDRLNAT-EDVYQLERR-LQLHGRRS------------------------ -------------------------------------------------------------------------SAPLASQ PPSPSPGLRPVLPSRLARASRGIGLSTGPS---------------RASLRAKNKIHPSSS-------------------- ------------------------------------------------------------------------------ >Monodelphis_domestica_PKD1 MPRGQGPPLAAPSPHGHGGPRPPPAPAPAPARFAFCLCLGLCIGGLSAAPDPGCQPCGLDCNCTPGPGGACSVNCSGRGL RGLGPELPIPPDVTALDLSDNFINT---LETEFFENLSALTQLDISNNKILTLEEGIFANLFNLSEINLSLNPFICDCNL SWFPSWVDEQKVSVVQPRETRCAEPPRLADVPILSVSFSDGTCDLEYIACVQDN----SSSAMTVVIFSAALDGEFTRNT CSAFCFSFGQQYGGLSEEGRCFCGTARSPNASSGCLRFCPGLAAPP-VACRVPFILHNVFP-ASLEASLWGPGGPQPAGH PVVFNVSTPLPANNLRWDFGDGAP-ALIAGPA----ASHRFILPGHYNVTAVLTLEVGTALLWTEVQVEAVPTELELLCP SWLQSNESLE--IGVRNRGGTGLSATYSITAESEQPAQ-----VVHPLCPSNTDIFPGNGHCYRLVVEKAAWLQAQRHCL AWGGGDLAIVGSPEIQRFLVSQVTR--SLDVWIGFTALTGPG----VPPHGEAFSLESCQNWLPGEPHPANAEHCVRLGP AGQCNTDLCTATHSYVCEFQPTGIVSSADNFFVGDAGSDLPGPTV-PVEERDFLSAPGRETVEVMIFPGLEMQQKGFLTA AEFETQDLMQPVQMRLQVYRP-VE----------GGIPENSSQPLCPSMDNQ-TWVPLDCLPGEHWCPLANLCLPLDSPC SLSPCANDSS-------PEQDNHWSGHYSLWREFLFSLPAGPSSQYSVSFSGKNISLLPGDLFSLQHDAGPG-------- SLLRFLPRPEALPHQRFQPECLSANASTWLPSLPAHFS--------------------------EVPVPNGSTCALRLLF ATEQVTRLLGQPSNPGLQHVGRYLFRASLDNGVSSHNLSCSFHVLSPVAGLRVIHPMP-QGGLFYVSTNW-TYLVLKISS GANS--TARRLGSNQSVPFEASCPLGVARLTADCARETND---------SWFALLEL---DGLGEDESLVEIVAENRVSL ENISIQVKAEEPIRGLSATPNPQTRVLQSTLVRYSPVV-----EAGSDVVFKWTIDDKQSLTFYNVVFNVIYQSAAVFKL SLTASNHVSNVTVNYNVTVEKMNKMRDLVVSEVPAIIPQNTT------LQLGASVQVDSAVEVTFLWTFGDGEQ-ESGQF KPPYNESFLVPEPGVHQVLIEHNVTHTYHV---PGDYNITVFVYNTLENLTQQVPLSVRASLPHVTVRTDSGALGVGHPI TFMPHPLPSPTGILYTWDFGDGSPVVLQNQPEVTHTYVSR---GVYNISLTVNNTVSSVGARL-SVRVFEEIRGLRVTST AATEKGMAVVVNASVEAGDNITWTFDMGDGTVLT-GPEASVQYVYLKDENCTIQVTAANPVSSVFQVLPIHIFVLEVLKI EPSSCIPEQPEVQLTAHVTGDYTHYVFDWTFGDGSSNATVYGHPTVMHNFTRSGVFPLSLVLSSLVN---KAHYFTSVCV EPEVSNITLQPERQFVKLGEEATLEVQAFP--PFLYRYSWDFGANDSAR--SGGTEASHTYRVPGIYLVTVTVSNNVSSD NDTAFVEVQEPLGITSIEVNSSH--VLELSQPYLFSVLGSGSPASYRWDLGDGQRQEG-LRVIHAYNHTGSYTISVVGWN EVSRSEAQLNVTVKRRIQGLSVNASRTVVPLNGSVSFTTTLEAGSDVHYSWVLCDRCTPILGSSTISYTFRSVGTFNIIV TAENEVSSLQDSIFIYVLQQIEGLQMLGGGE--G---------GCFPTNRTLQLQAAVRDGTNISYSWALQQDG-G--LS HAAHGKVFSLTVLEAGTYHVQLKAINMLGSAVVNRTLEFVEEVGQLAASASPNPAAVNTSVNISAQISSGTSITYAWLLQ -EGVSVEAAEPFIVHSFSSPGLWAVTVTAGNQLGSVNATVHVDVQEPVAGLTVGCG-ESGSRFVASGSLVYFWGDLELGS NVSWSWELP-----DG--PRSGQRIAAVFPHAGAFSIRLNASNAVSWTTASCNITVEDPIQGLELWASSRVVEPGERVQF NIHLTAGSDVNYRLLISG--GVTTALG-EPHFSHSFPRVGDYMVTVQAENHVSWEQVQVRITVLEAIGGLQIVGCCELGI PTGGERNFTARVQRGSRVSYAWYFSLQKVQGDS-LVILSGREVTYTPVAAGQLEIHLHAFNDLGSVNLTRTIEVQDLIQA VELHPES--CFTNRSAQFEAATTPSPRRVFYRWDFGDGSQ-THVTATPSSNHTYLFPGDYTIKVNASNLVSFLVAKTTVT VRVLECEEPEVEVALPTQVVMCRSQRSYLEAHINLRGCVTYQTEYHWKVYRAASCLHYRRSAH-------------VPLP GVDVSRPQLVVPRLALAVGDYCFVFVVSFGDTPLSRSIQANVTVTPGRLVPIIDGGSYRVWSNARDLVLDGGKSYDPNLE DGDQTLLSFHWACVSSSKSHPGG--------CPLNFGP---RGSSIITIPKERLEAGVEYTFNLTVWKAGRKEEVTNQTV LIRNGLVPIVSLECVSCKAQS--VYEVSKSSYVYLEGTCHNCSSGSKRGRWAAQTFSNKSLVLDESTTSTGSSGMRLVLR RGVLRDGEGYTFTLTVLGCSGEEEGFASIDLFPNRPPIGGSCRLFPHE--------------AVKALTTKVHFE-----C TGWRDTEDENAPLVYSLLMRRCR--QGYCEEFCIYKGSLSAYGAVLPPGFKT----HFTVDLSVVVQDQLGAAVVALNKS LLITLPEPSPSFHC----LTHWLYSLTETVLPGLVKQADPQHVIEYSLALISVLNEY----EQVTSSEEEASHERQLRGL MRKNITEMLVSLRVNTVD---DIQQISAALAQCTVASKEFVCPSCLRKTLNKLENMMAILQNETTQGTVTPTAIADNILN ITGDLIHLVNSDPQGL--------------------------VPTELCAAGG--LMASRAYNLSSDLMRILMKSRVLNEE PLTLAGEEIVAQGKRSDPFSLLCYENTS--D---CQFSIPPAFNSTFS----------DLTDVVQLIFLVDS--NPFP-F GYISNYTVSTKVASMAFQTQAGAQIPIERLGSEKAITVKVSNNTSGGGGGDRVLS------TSTAIIQPRTSVSAIIAPE NHNPEAGLHFQLTYTVLNE-----RYLSEEPEPFLAVYLHSAPQPNEY-NCTASKKIGLKALAG---GDHRPYTFFISPG TDDTTASYYLNMTSHFH----W-----SEVEVTVGLYTSLCQYFSEKEMMWKTEGIV----------------------- ----PLEETSP---------------------SQAVCLTRHLTAFGAS--LFVPPSSIQFIFPEPAPGINYIVLLTCAVC LATYVVTALIVHKLDLMDVSR-VSIIPFCGK----NGRFKYEILVKTGWGQGSGTTAHV--G-----ITLYG-ADGRSGH RHLDGESA---FHRN-----------SLDIFQIATQRSLGSVWKIRVWHDNKGLSP----AWFLQHIIVRDLQTGRS--- ----------AFFLVNDWLSVETEDNGGLVEKEVLAASDATLRRFPRLLTAELQRGFFEKHIWLSLWDRPP--------- -----RSRFTRVQRATCCALLICLFLGANAVWYGVVGDASTPPSHPEPLIPLSVDTVAVG-------------------- ---------------LVSSVVVYPLYLVILFLFRMSRSKVSVSPDRSPA-GQQMLDIDNYLETSVLDSSFLTLSGLHAE- AFSGQTK---------TDLFLDDSKSLMHWQSSDGTLSWPDLLSDPSIMGNT---------------------------- ----LQRLVRARAGNPPGLET----MEEDGLSLGSPPSQTKYFSTSDEDLIRQILAEGASSIAPARDT------------ -------------------------------------------------------------------------------- -----------------------------------------------------------------HLETDLLTGLSGTLG AKTEALM--LQRLNEKGLP------PAAPTQELVQSAKFTRGGLAEGLRKRLLPPWCAPLAHGLSLLLVLVAVGISGWIG --TNFTSSVGVMWLISGIFSFLSSFLFWEPLKVLLEALYFSL----------------VAKRLHPEEDDTLVECP-AVEP VC---------------------ERIPRVRPPQGFALFQAKEEARKVKLLHRMLKNFLVYMLFLLVTLLTNYGDAS---- -SHTHAY--RLQSSIKQELDS----------KAFLGITRSDEFWGWMSRVLLP-YVHGN----------QSALE-----L GPPRLRQVRLQEGLCPDA-----------------LGSVRRVCATSS-SFSTKDYEVGWES------------------- ---------SSPNGTRAWAYSAPDLAGVWYWGYFSVYDSGGYVQELGVSLEESRELLGFLQRHNWIDNMSRAIFVELTQY SPAVGLHAAVTLRLEFPVSGRALTAISVRPFPLQRLSAGVTLQLLMMVF---LMLFVVYFVVAEALAMQKEG-------- -------------------------------------------------------------QAYLVRAGAWGQWLLILLT TATVLIHLSQLSLADQQWGRYLKRRPHHFT---------------SFYQVAQLSSAFASLAASLLFLLMIKAAQQLRFIR QWSVFGKTLYRSMRELVAAG-----LALLVLAVAYTQLGFMLFSSCSDSLRSMGWDLFLLCPAGGDPH------------ --VCPSEPWRLSPLLCTSLMVLQLWGALRLGAVVLRRRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRH KVRFEGMEPLPSRSSSDSKSSQDVSPPSAGSDTSRPSTS--SSQLDGMS------------------------------- -LLMGRAGARGDPEPEPSRLLSVFEALLAQFDRLNQATEDVYQLERRLQGIQGWRSRDHLASPPWAP------------- -------------------------------------------------------------------------GPPIPSP SPGPPAGNQGTLPARIARASRGIGMAATQAS--------SGSPLVRASIRAKNRIHPSLT-------------------- ------------------------------------------------------------------------------ >Gallus_gallus_PKD1 ----------------------------------------------------------------------------QGLE FIGNKQRLISEISILRDLSRNKISA---LDVQMFRSLTSLAKLDISHNKISTLEEGIFDNLFNLSEINLSWNPFFCDCKL SWLPRWVEDRKVTVLQAADTRCAHPPGVANLSLFSVSFVNATCGAQYVTCLTSNH---TDEAELVILFTSSHPGNLTEET CSALCYADDQEYGGFSPQGQCLCGTAHEPNSSSSCLLFCTEHSSG--QACGGPSLIHFPFQ-AQLSVSFIGLKPRYSLHE AVLFNVSIPIAVSTLIWEFGDQTEVLNTTGNA----AVHTYALPGQYNVTATLFVGTKVSYVQAEIEVVASPQQLELQCP SLIKTNESLD--IRIRNRGGTGLTVLYGITAESGEPGR-----AVHPMCPHDGLVFPGNNHCYQLVVEKAEWLEAQQHCQ EHGNGELAFVSSPEIQSFLVTHVIRR-SLDVWIGFNDFASSE----AQQRGEGFNIESCQNWLPGEPHPSNADHCVRMGP TGQCNTDLCMAKHSYVCEFKPKGVLLNAENFFVGDPVFDTHVAAK-NVIED-TLSSP-LQAVEVMVFPELAFRHEGYLSA LEFVTQELHQPIQMRFQVHRPIDGKE--------YQEGQNATEPFPTSQDDG-NYTLVECPPGFQWCHLTNLCSSVNNCC NAMECTNSSFASSPIPASPQHKGSQLSYELVKEFLFTIPAGPSAPYLVTFSKEDVFVRAKDVLSIQHNAGMG-------- SFLQCQP----STTSPFRTNYFSTNSSDWALGLPASSI--------------------------GATWIHNTVCSLRVLY AKEQLVPIIS-PQNAGLAHPGLYTVRASVDNGIFSANLSCNFWVTSQVSGLRVVHPAP-QGGKVYVPSDH-ITLVVKISS GMNAT--ARWLGDNHTFPFEEACPLTIAPLTSDCARENND---------TWFAVLSL---SGLKEGASTHTLVAENAISS QNITITIKVEQPIRGLRATPDPESRVLLNTRVSYVPVM-----EAGSDVTFRWTVDDKPSFTFYNVVFNVIYQSPAVYKL SLTASNHVSNFTVNYNVTVEMMNKMKNLTVLGIPPVLPQNST------VEFTARVQVDSAVDAMFLWDFGDGIQ-ETYQF TPPYNKSFLVPDPSVHEVIIEHNVSHVYEY---PGDYILVVQVSNQFENLTCLTPVRVHSYLVDVQIETVKDVLVVNRSV TFRAIPLPSPYGVLYTWDFGDGSSLVTESQSTVTYSYSSR---GVYNISVSANNTINSVETVE-CYQVFEEITGLHVAAD EVAEVGATVTLNASVQTGDSITWIFDMGDGTVLR-SQVPVVEHVYTKDINCTVNVTAVNPVNSVSQTIPVWIFVLEVLRI DPTSCILEHPDVQLTAYVTGNPDEYIFDWTFGDGSSNVTVSGDPVVMHNFTRSGTFPLSLTLSSRFN---KAHYFTSVCV EPEIVNVTLLPSKQFVRLGEECSFQVSAVP--LYQYRYRWDFGNNESTR--SSGTEVSYNYKSTGVFLVTVTVSNNVSFN NDTAFVEVQEPVGVAKIEYNGTK--VLELNQIYLFSASMNGTKVNYFWDFGDGITQPG-QITTHSYNNTGHYTISVTGQN DVSTNETRVDVTVKRRLHGITINASRTIVPLNGSVSFVATLVAGSAIRYSWILCDRCTPIQGSSTISYTFRSVGTFNVIV TAENEISSLQDSIYVYVLEQIEGLQVASSDLVED---------LYFPTNKTLHLHAVVREGTNISYSWIAQKDG-N--AV QTATGKTFSLNVLEAGNYTVYLKATNMLGSTTANKTLEFIESLGLLKPYAFPNPVAVNASVNISATITSGTGIVYVWYLE -DGLSPVTSESFIIHSFQSPGAMEVVIGAENKLDSTNATISVYVEEVIEELSIGTA-ELDCRYVSSGSTVVFEGELQKGT EVTWLWEVP-----NG--TLTGQSVAVMFPTAGFYTVYLNASNDISWAVASRNISVLDRIQGLEVIASKKVVEPGEQVTF VIRMSSGTSVSYLVSISG--DYSVVLN-GSKYTHEFTKSGDYLVTVTVQNQISIAHAQVLISVLEAVRDIRLLNCCERGI PTGTEKSFSAQVGSGSRVLFSWQFSLWKERGRS-VVTAAGESVSYTPEAAGLLEIHLRAFNDLGGINITRTIQVQDPILQ VSLTASN--AFVNRTALFEAAVIPNGRGVEFLWTFGDGSS-TQMTRVAVANYSYLSPGDYLVEVNATNLISFFVAHLTVT VKVLECEEPEVELALPPQVVMKRSQRNYLEAQLDLRGCIKYQTEHLWEIYRAPSCLHLDDSSR-------------IHLP NVDVNRPQLVIPKLALEVGNYCFVFIVSFGDTPLSKSIFANVTMIPSKLVPIIDGGSYRVWSNTQDLILDGEKSYDPNLD DGEQTPLFYQWSCTFSSKSSAAG--------CSLNFSA---NGG-NVTIPKAVLEADVEYTFNLTVWKKGMNPEATNQTV FIKRGGVPIVSLECVSCKAQS--VYEVSKSSYVYLEGTCQNCHNDSKIGRWAAHSFKNKSLILDKKTTSTGDTGMNLVLR QGALKDGEGYTFTLHITDLTTGEEGFASIDLLPNQPPIDGSCQLSPKG--------------PLRALMAKVHFE-----C TGWRDTESAEDPLVYILLASRHR--AGHYHEFCVYKGSRAEHSAFLPPGFHES---GFVVSVSVLVQDQLGATVVAINQS MEIGLP---EGFPS----LSYWLYNQTDTVLQGLVKQGDPQQVIEYSLALITILNEY----ERSMLLEPETGNEFELRTW TRNNITETLNSLNVNTVD---DIQQISAALAQCTVVSKELVCKSCLTRTLNKLESMMTILQGEMTQGTVTPTGIADNILN ITGDLIHLVNTVSQES--------------------------KPQELLADSHNLLLAPKAYNLSSSLMRILMKSRVLNEE PLELVGGEIKATGKRSDPFNLLCYENTP--N---CQFSIPQAFNTTLS----------NLTDVIQVMFQVDS--NPFP-F GYINNYTVSTKVASMEFQTYNGVQIPIGSLDSERAITVMVSNNTDADNLS-----------AGTEVIEARTSVNLIVTME NNNREAGLHFRLTYKVLND-----RYVASEPEPFIMAYLHHEPEPNEH-NCTASKKISLEALSG---SDHKLYTFFTSPL TDDTIQKYYLNITNHFS----W-----SPVEVTLGLYTSLCQYFSEQEKRWKTEGII----------------------- ----PLEETRP---------------------DQAVCLTQHLTAFGAS--LFVPPNSVQFIFPAPGSGLNYIVLLTCAVC FVTYSVAALIVHKLDMIDINR-VGVIPFCGK----NGLYKYEILVKTGWGRGSGTTAHV--G-----IALYG-VDNKSGH RHLDGENA---FHRN-----------SLDVFQIATERNLGSIWRIRIWHDNKGLSP----SWYLQHVIVRDLQSSKS--- ----------YFFLVNDWLSVESEENDGMVEKEVYAASETELRSFSRIFIAELQRGFFEKHVWLSMWDRPP--------- -----RSRFTRVQRATCCSLLIFLFLCANAVWYGVVGNVHLSSGAVSNLIPVNVDTVAVG-------------------- ---------------LVSSVVVYPLYLVILFLFRMARAKVSINHTVTHS-DQQSLEIDNYLDSSVLDSSFPTFPGLRAEQ AFSEQTK---------TDLFLEDSKSLIRWPSSEALLSWPDLLSDPSIMGNT---------------------------- ----IQKLKRGRASRHLGLEAPLA-TEEDNLSLGVHQGQPRYFSASDEDLIRQILADGASGISHSQDLGPYM-------- -------------------------------------------------------------------------------- -----------------------------------------------------------------RAETDLISGLSSVFG EKVETVM--MQKLNDKGQ------SMAAPPREVSRSAKSTWTVADQTFRKRLLPSWCSYLAHGISFFLFATSTGVSVWIG --VGFSSSVALMWLISGIFSFLASFLVWEPLKVLLEALYFSL----------------VAKRLHPEEDDTLVEHP-FVEH VS---------------------EKISKVRPPQGFALFQAKEEARKVKLLHRMLKNFLIYMMFLLVILLTNYGDAT---- -RNSRAF--LLQSSIKQQLGS----------SEFLHIKRSDQFWVWMSQVFLP-YLYNN----------QSGQESYSTTL GVARLRQLRLQEVLLP---------------------PEIEKNCIDSHSFSTADYAAGWER------------------- ---------AAVNVTTAWSYSPPDLTGVWYWGYISFYDSGGYIQELGTSLEEGRAQLNYLQQHTWIDNMSRVVFVELMQY NPSVDLHAAITLQLEFLGAGQAVTTVTISPFPLLRLSSGVTLQLLMMVF---LMMFVVYFVVSESLSIKKEG-------- -------------------------------------------------------------RAYFTLWGNYGQWVFILLT TCTVVVHLSQATLADQQWLKYLNNR-KVFT---------------NFYQVAFLNTVFSTLAASLLFLLIVQAAQQLRFVR QWSVFGKTFQKSMKELTAAG-----LAFVVLILAYAQLGFLLFSSSSESFRSVGSSLLLLIAMVRGGVSLY--------- --PCPPDSSGLYYLFCTSYIILEVWIVLRLFTVVLVYSYREMHFEMYRPAFEPQDYEMVELFVRRLKMWMGFSKAKEFRH KVRFEGMEPLPSRDSSDSKSIR-GPTPSAASDSSRASTS--SSQLDGLS------------------------------- -LVLSTRDSLEVDAD-LQRLLSLFEMLLAQFDRVNQVTEDVYRIEHQLQGSQSRRSRRRY-------------------- ---------------------------------------------------------------------------CAGNT ERGPSPETRSSVPSHLIRASRGISGAASVLPPHKAHSTLAPAVKKKRPLRAKNRVHPTVK-------------------- ------------------------------------------------------------------------------ >Taeniopygia_guttata_PKD1 -------------------------------------------------------------------------------- ----------------------------------------------------LEDGIFDNLFNLSEINLSWNPFVCDCKL SWLPRWVEERKVRVLEASDTRCAHPPEVANLSLFDVLFLNATCGAQYITCLTGNY---TEEAELIILFTSVHPGNLSEET CSALCYSQEQEYGGFSPQGQCVCGAAHETNSSSGCLPFCTEHLSG--QGCGGPSLVPLPFQ-AQLPVSFTGLQPRYSLHQ PVLFNVSIPIAASTLLWEFGDRSEVLNTTAHT----AVHSYALPGRYNVTATLLVGSRLLQEQAEIEVVASPQQLELQCP SLVVANESLD--IRIRNRGGTGLAVLYGITAEPGQLGR-----AVHPMCPPEGLVFPGNNHCYQLVVEKAEWLEAQRHCQ ELGDGDLAFVSSPDIQSFLVAHVIR--SLDVWIGFNDFASSG----AQQRGEGFNLESCQNWLPGEPHPSNADHCVRMGP TGQCNTDLCMAKHSYVCEYKPPGVLLNAENFFEGEAELGTEEAVR-SVSEA-VLADP-WQAEEVLEFPELAFRHQGFLTA LEFVTQELHQPVQVRFQVWFCS----------------FEEIKPWGSGLEKI-TEEKPLSMPEESWCPLTSLCSSHNSCC NGTECANSSFGSSPAPGAPQPSDSQPSRELLKELLFTVPAGPSSQYQVTFRKENIFVRAGDVFSIQHSAASG-------- SFLRCRR----RAASAGRG-----NCSAWAAGSCHSPA--------------------------GAPRANSSACSLRVRY AEEQLVPVLS-PHNAGLERPGGYAVRASVGNGLFSANLSCGFRVASRVSGLRVLHPAP-QGSRLYLPTNH-TALLLKLSS GVNAT--ASCLGDNRTVPFVATCPPALAAL---CARETND---------TWFAVLQL---GGLGQGLSTHVLVAENSVSS QNITVTVKVEEPIRGLRATPDPESRVLLNTRVSYIPVM-----EAGSDVTFRWTVDDKPSFTFYNVVFNVIYQSPAVYKL SLTASNHVSNFTVNYNVTVEMMNRMRNLSVVGALPVVPQNSS------VEFSARVHVDSAVEALFLWDFGDGVQ-ETYLF KPPYNKSFLVPDPSVHEVVIEHNVSHIYQD---PGEYALMVVVSNQYENLTHLSPVQVHSYLVDVKVEAEEDVLVVGRPV TFRAAPLPSPYGVVYTWDFGDGSSLLTDTQPSVTYSYPRR---GVYNVTVTANNTVSSVETVE-CYQVFEEVTGLRVSTA EAAEQGAAVTINASVETGDSITWIFDMGDGTVLR-SQVPVVEHVYIKDINCTVNVTAVNPVNSVSQAVPVRIFVLEILKI EPTSCILEHPDVQLTAYVTGNPEEYIFDWTFGDGSSNVTVSGDPVVVHNFTRSGTFPLTLTLSSSFN---KANYFTSVCV EPEILNVTLLPSKRFVRLGEESSFQVSAVP--PYQYRYRWDFGNNESTR--SSGTEVIYTYKNTGVFLVTVTVSNNVSFN NDTAFVEVQEPVGVAKIEYNGTD--VLELNQIYLFSASMNGTKVSYCWDFGDGTVQPG-QVATHSYNSTGHYSITVMGQN DVSSNETTIDIAVKRRLFGLTVNASRTVVPLNGSVSFVATLVAGTAIRYSWILCDRCTPIQGSSTISYTFRSVGTFNVIV TAENKISSLQDSIYVYVLEQIEGLQVASTDLVED---------LYFPTNKTLHLQAVVREGTNISYSWVVQRDG-N--AV QTFTGKTFPLSILEAGNYTVYLKATNMLGCATANRTLEFMESLGVLKPYAFPNPAAINASVNISATITSGTGVTYVWYLE -DGSSPATSEPFILHSFQSSGMIEVIVGAENKLNSTNATVSVCVEEVIEGLTIGTA-ELDCRYVSSGSTVVFEGELQRGT EVTWLWQVP-----NG--TLSGQSVAVTFPTAGLYTVHLNASNHISWALASRNISVLDRIQGLEVVASKKVVEPGEQVTF EIRMLSGTSVSYLVSISG--DYSVVLN-GSRYNHEFTKSGDYLVTVTVQNQISIAHAQVLISVLEPIQDLRLLNCCEEGI PTGTEKSFSARVGSGSRVSFSWQFCLWKERGRS-VVAASGERVSYAPEAAGLLEIHLTAFNDLGSVNITRTMQVQDPIVQ VSLSATN--AFVNRTALFEAVVVPSSRSVEFLWSFGDGSS-TQTTRVAVANYSYLSPGDYLVEVNATNLISFFIAQLTVT VKVLECEEPEVELALPPQVVMKRSQRNYLEAQIDLRGCIKYQTEHLWEIYRAPSCMNLDDSSR-------------IRLP NVDVNRPQLVIPKLGLEVGSYCFMFIVSFGDTPLSKSIFANVTVIPSKLVPIIDGGSYRVWSNTQDLVLDGEKSYDPNLD DGEQTPLLYEWSCTSSSKSSAAG--------CSLNFSA---KEG-IVTISKALLEADVEYTFDLTVRKEGMSPEATNQTV FIKRGGVPIVSLECVSCKAQS--VYEVSKSSYVYLEGTCQNCHNDSKLGRWAAHSFKNKSLILDKTTTSTGDTGMNLVLR PGALRDGEGYTFTLHITDLTTGEEGFASIDLLPNQPPVGGSCRLSPEG--------------PLRALVTKVHFE-----C AGWRDTEDAEGPLVFILLASRHR--PGHFHEFCVYKGSRAEHGAFLPPGFHES---GFQVSVAVLVQDQLGATVVAVNRS MEIGLP---EGFPS----LSHWLYNQTDTVLQGLVKQGDPQQVIEYSLALITILNEY----ERSVLLEPEAGQEFELRTW TRNNITETLNALKVNTVD---DIQQISAALAQCTVVSKELVCKSCLTRTLNKLETMMTILQGETTQGTVTPTGIADNILN ITGDLIHLVNTVSQES--------------------------KPQELLADSHNLLLAPKAYNLSSSLMRILMKSRVLNEE PLELVGGEIKATGKRSDPFNLLCYENTP--N---CQFSIPQAFNSTLS----------NLTDVIQVMFQVDS--NPFP-F GYISNYTVSTKVASMEFQTHNGVQIPIGSLDSEKAITVMVSNSTEPENLV-----------AGTEVIEARTSVNLIVIME SNNREAGLHFQLTYRVLNE-----HYLASEPEPFIMAYLHHEPEPNEH-NCSASKRISLDALAG---SDHKLYTFFTSPR TDDPIQKYYLNITNHFS----W-----SAVEVTLGLYTSLCQYFSEQEKRWKTEGIV----------------------- ----PLEETRP---------------------DQAVCLTQHLTAFGAS--LFVPPNSVQFIFPAPGPGLNYIVLLTCAVC FVTYSVAALIVHKLDVIDTNR-VGVIPFCGK----NGMYKYEILVKTGWGRGSGTTAHV--G-----IALYG-VDNKSGH RHLDGDNA---FHRN-----------SLDVFQIATERSLGSVWRIRIWHDNKGLSP----SWYLQHVIVRDLQSSKS--- ----------YFFLVNDWLSVESEDNDGLVEREVFAASESELRSFWRIFVAELQRGFFEKHVWLSLWDRPP--------- -----RSRFTRVQRATCCCLLIFLFLCANAVWYGVVGSVHLSNVAISSLIPVSVDTVAVG-------------------- ---------------LVSSVVVYPLYLVILFLFRMARGKVSISHTVTHS-DQQSLEIDNYLDSSILDSSFPTFPGLQAE- AFSEQTK---------TDLFLEDSKSLVPWPSSEALLSWPDLLSDPSIMDNT---------------------------- ----IQKLKRGRASRHLGLEAPLA-AEEDALSLGIHQGQPRYFSASALNVIRQFLTDGHTGL--FQGLGPYV-------- -------------------------------------------------------------------------------- -----------------------------------------------------------------RAETDLISGLSSVFG EKVETVM--MQRLNDKGQ------SVAPPPREVSRSAKSTWTGTRATFRKRLLPPWCSLLAHGISLLLLATAAGVSVWIG --VGFSSSVALMWLISGIFSFLASFLLWEPLKVLLEALYFSL----------------VAKRLHPEEDDTLVEQP-CVEH VS---------------------ERISKVRPPQGFALFQAKEEARKVKLLHRMLKNFLIYMMFLLVVLLTNYGDAS---- -RTSRAF--LLQSSIKQQLGS----------SDFLLIKRSDQFWVWMSQVFLP-YLYNN----------GSGQESHSTTL GTARLRQLRLRGAECPGH-------------------PAGHGHCTDQHSFATADYEVGWES------------------- ---------TAGNGTAAWAHSAPDLAGIWYWGYISFYDSSGYVQELGPSLEQSRAQLEFLQQHTWIDNMSRAVFVELLQY NPSVDLHVALTLRLEFPGAGQAMAAVTVSPFPLLRLSGGVTLQLLMMVF---LMLFVVYFVVSESLAIKKEG-------- -------------------------------------------------------------RAYFTLWGNYSQWVFILLT TCTVLVHLSQATLADQQWLRYLSNR-RGFT---------------NFYQVAFLSSVFSSLAASLLFLLTVQAAQQLRFVR QWSVFGKTFQKSMKELMAAG-----VAFALLLLAYAQLGFLLFSSSSESFRSVGSSLLLLLALLRGSASLR--------- --PCLPEASGLCCLFCTSYVVLEVWIVLRLLAAVLIHSYREMHFELYRPAFEPQDYEMVELFVRRLKMWMGFSKAKEVR- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ >Anolis_carolinensis_PKD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------MDCPSGSHWCQLTNSCLPLGGCC NKFESCANSSMASTPSPIAHRCPNPPSMVQVQESLFIVPPGPSMMYLLLFKNKDVSIGPNDTLSIQHDAGPG-------- AFLLCHR----NRVPSSPTSYFSWNSSAWEMDFHPSFH--------------------------ASKWHNDSECEFRLLC TTEETSPIIR-KQNFGIPSPGFYTLRATISNTVFATNVSCDFGVESPISGLRVVSPPE-QGGILYVEANH-TFLVVKISS -GGANTTVGWIGGNRSTLFEKTCPVSVVK----CGPKTDD---------TWFAVVSL---EGIAENGSTVVLQAENTVST QNLTVVVKAEEGIRGLRATPDPESRILLNSRVTYVPRM-----DAGSEVTFRWTVDDKPSFTFYNEVFHVIYQVPAIYKL SLTASNHVSNVTVDYNITVEKMNRMKDLLVSEVPQRAPQNGT------LDLAASVRVDSAVKATFLWDFGDGNN-ASSQF QPPYNDSFLVPDPTIHQVVIAHNVSHAYQE---PGEYTLTVVVYNEFENLTYSVPIHIYSYLMDLTMEADTDVLVAGRPV TFKAHPLPSGFGVSYVWDFGDDSMVYVESQPTIVHTYNTK---GIYNVSLRANNTISTMETFW-CYRVFEEITGLHVTME EAIEVLMPLEISASSETGDNITWIFDLGDGTVVE-TSEASVNHSYLKEMNVTVNVTAMNPVNSVSRAVPIQVFLLMVLKF EPSACIVEHPDVQLTAYVSGNAEDYVFDWMFGDGSPNVTVYGDPTVRHNFTRCGIFSLSLAISSKVD---KIHYYTVVCV EPEVTNVTLFARSSFVMLGNESKFQVTALP--PYPYRYHWDFGTNDSLK--FGGTEVSYTYKAPGIYLVVVTVSNNVSFN NDSALVEVQEPVGVARIESNASK--VLEVNQVYLFSANVSGTKVRYLWDFGDGTTQLG-KFITHSYNKSGIYAVSLKAWN EVSFREARVNVTVKRRLQGLSINASRTVVPLNGSVSFTATLLAGTAIRYSWILCDRCTPILGSSTISYTFRSIGTFNVIV TAENEIGCLQDSIFIYVLQQIEGLQIVGAGLLDN---------TYFPTNKTLQLQANIRDGTNISYSWAVVKES-H--SV QTFTGKTFSLVILDAGVYIVHLKATNMLGTLAVNKTIEFIEPVGVLKLVAFPNPVAVNASINVSAAISAGTGLEYTWYLE -NEVPVTTVFSSITHFFQSPGAKEVTVEAENKLGSTNATLMVFVQEPVTGLRIRTL-RPNCTYIESGSVVNFSGELESGS DVSWVWKMP-----NG--TISGQRVALTFPTPGFSSVCLNASNDVSWEGACHNLTVQDAIRDLRLSVSKRVLEPGEEASF SIGMSSGSSVRYEVSIAG--NQSMVLN-ASNFSYTFTRVGDYVVQVTAENYVSVVHTEVHIVVLEAVRGLRLVDCCEQGT PTGVERRFAAEVEAGSRVSYQWRITLTEDEGRSQVATLEGPSISYMPEVAGRLDVHLQASNLLGGLNVTVVIQVQDLITQ LSLLPVK--PFANRTTSFTVSVRPNARQVGFLWRFGDDSP-VLRTDVASASHTYLQPGDYLVEVNATNLISSSFARLTVT VRVLECEEPEAELALPAQVVMKRSQKNYLEAQINLRGCTSYKTAYLWEIYRAPSCLQMGSADK-------------VHLP HVDATRPQLVIPKLALDLGNYCFKFLVSFGDTPLSKSTFANVTVLPNKLVPIIEGGSYRVWSNTRDLVLDGGKSYDPNLE DGEQTPLLYSWSCVSSSKSPSSK--------CALDFSA---RGG-VVTVSRAILEADVEYTFALSVWKEAMSPESTNQTV FLKRGTVPIVSLECVSCKAQS--VYAVSRSSYVYLEGTCLNCQNNSKMGKWAAQSFKNKTLPLDRSTTSTGDAGMNLVLR PWALKDGEGYTFTLRITDLASGETGFASMDLLPNQPPFGGSCWLSPMG--------------PLQALTAKVHFE-----C TGWRDTENEGTPLVYVLLATRCR--SGHCEEFWVYKGSHAEHAAFLPPGFQEN---GASVSVSVLVQDQLGATVVAFNSS LAITLPVVPEGFGS----LPQWLSNQTKVVLQGLVKQGDPQQVIEFTLALITILNEVG--RSHPASPGAEIEGDDRLRAW MRRNITETLVSLNVNTVD---DIQQIAAVLAQCTVANKAFVCRDCLKKTLEKLESMMDILQGETMQGTMTPTAIADNILN IMGDLIHLVNTASREL--------------------------VPQELGSGQSPVEVASKAYALSSDLMRILMRSRVLNEE PLELAGTNITATGKRADPLGLLCYDQDD-PE---CQFSLPPAFNTTFS----------DLSDVVQVMIRVDY--NPFP-F GFVANHSVSSEVASLEFQSHNGTEIPVGALEPEKAITVMVADPREKDIT------------AGTVVIEEAGSVSAALRVE SRDPEAGLYFQVTFSVLND-----RYVSSEQQPSIAVCFFPAPEPGIVPNCTDTKEIYLEDMNRRPEGDHRQYTFFVSPV TEEAEKEYFFNITNHFL----W-----SPVEVTLGLYGSLCQYFSPEEIRWKTEGLA----------------------- ----PLEGTTP---------------------ERAVCLTRHLTAFGAS--LFVPPHSLQFLRPPPGPGFNYIVLLTCAVC LVTYFVAAVIVHKLDLIDINR-VGVIPFCGK----NGLYKYEILVKTGWGKGSGTTAHV--G-----ITLYG-MDSKSGH RHLDGENA---FRRN-----------GLDIFQVATERSLGSLWKIRIWHDNKAYPT----FWIIQHIFVPRIANKVL--- ----------LLYYYNPGLQINFEANHGPSRVKSLANMMATTYWSLRQMMG-----QYDDHDPLLDSSFEN--------- -----WWTSMVVVACCWASLWVKSLANMI