>Homo_sapiens_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MTTQQIDLQG----PGPWGFRLVGGKDFEQP--------------LAISR---VTPGSKAALANLCIG--- --------------------------DVITAIDGENTSNM----THLEAQNRIKGCTDNLTLTVARS------------- ---------------------------------------------------------EHKVWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHIGSAHNRSAMPFTASP---------ASSTT------------------- -------------------------------------------------------------------------------- --------------------------ARVITNQYNNPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNNALESKTAASGVEA------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NSRPLDHAQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PPSS---LVIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRD--- --RHRHPECY--------------------------VCTDCGTNLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYEVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Mus_musculus_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MTTQQIVLQG----PGPWGFRLVGGKDFEQP--------------LAISR---VTPGSKAAIANLCIG--- --------------------------DLITAIDGEDTSSM----THLEAQNKIKGCADNMTLTVSRS------------- ---------------------------------------------------------EQKIWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHIGSAHNRSAMPFTASP---------APST-------------------- -------------------------------------------------------------------------------- ---------------------------RVITNQYNSPT------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNNAVESKTSASGEEA------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NSRPVVQPH---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PSGS---LIIDKDSEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESDG--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASVGN----------AQKLPICDKCGTGIV-----------------------------GVFVKLRD--- --HHRHPECY--------------------------VCTDCGINLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYDVVTVFRE----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Pan_troglodytes_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------VTPGSKAALANLCIG--- --------------------------DVITAIDGENTSNM----THLEAQNRIKGCTDNLTLTVARS------------- ---------------------------------------------------------EHKVWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHIGSAHNRSAMPFTASP---------ASSTT------------------- -------------------------------------------------------------------------------- --------------------------ARVITNQYNNPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNNALESKTAASGVEA------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NSRPLDHAQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PPSS---LVIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRD--- --RHRHPECY--------------------------VCTDCGTNLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYEVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Gorilla_gorilla_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------VTPGSKAALANLCIG--- --------------------------DVITAIDGENTSNM----THLEAQNRIKGCTDNLTLTVARS------------- ---------------------------------------------------------EHKVWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHIGSAHNRSAMPFTASP---------ASSTT------------------- -------------------------------------------------------------------------------- --------------------------ARVITNQYNNPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNNALESKTAASGVEA------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NSRPLDHAQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PPSS---LVIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRD--- --RHRHPECY--------------------------VCTDCGTNLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYEVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Pongo_abelii_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MTTQQIVLQG----PGPWGFRLVGGKDFEQP--------------LAISR---VTPGSKAALANLCIG--- --------------------------DVITAIDGENTSNM----THLEAQNRIKGCTDNLTLTVARS------------- ---------------------------------------------------------EHKVWSPLVTEEG------KRHP YRMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHIGSAHNRSAMPFTASP---------ASSTT------------------- -------------------------------------------------------------------------------- --------------------------ARVITNQYNNPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNNALESKTAASGVEA------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NSRPLDHAQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PPSS---LVIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRD--- --RHRHPECY--------------------------VCTDCGTNLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYEVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Macaca_mulatta_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MTTQQIVLQG----PGPWGFRLVGGKDFEQP--------------LAISR---VTPGSKAALANLCIG--- --------------------------DVITAIDGENTSNM----THLEAQNRIKGCTDNMTLTVARS------------- ---------------------------------------------------------EHKVWSPLVTEEGG-----KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHIGSAHNRSAMPFTASP---------ASSTT------------------- -------------------------------------------------------------------------------- --------------------------ARVITNQYNNPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNNALESKTAASGVEA------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NSRPLDHAQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PPSS---LVIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRD--- --HHRHPECY--------------------------VCTDCGTNLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYEVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Rattus_norvegicus_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MTTQQIVLQG----PGPWGFRLVGGKDFEQP--------------LAISR---VTPGSKAAIANLCIG--- --------------------------DLITAIDGEDTSSM----THLEAQNKIKGCVDNMTLTVSRS------------- ---------------------------------------------------------EQKIWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHIGSAHNRSAMPFTASP---------APGT-------------------- -------------------------------------------------------------------------------- ---------------------------RVITNQYNSPT------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNNAVESKTSASGEEA------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NSRPSAQPH---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PSGG---LIIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESDG--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASVGN----------AQKLPICDKCGTGIV-----------------------------GVFVKLRD--- --HHRHPECY--------------------------VCTDCGINLKQKGHFFVG--------------DQIYCEKHARER VTPPEGYDVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Canis_familiaris_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------M----THLEAQNKIKGCTDNMTLTVTRS------------- ---------------------------------------------------------EQKIWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHIGSAHNRSAMPFTASP---------ASSSA------------------- -------------------------------------------------------------------------------- --------------------------PRVITNQYNNPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNNALESKTAASGQET------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NGRALDHSQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PPSG---LVIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRD--- --RHRHPECY--------------------------VCTDCGTNLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYDVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Felis_catus_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------Q---VTPGSKAAMANLCIG--- --------------------------DVITAIDGENTSSL----THLEAQNKIKGCADNMTLTVTRS------------- ---------------------------------------------------------EQKIWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VPHIGSAHNRSAVPFTASP---------ATSSA------------------- -------------------------------------------------------------------------------- --------------------------PRVITNQYNNPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNNALESKTAASGQET------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NGRALDHSQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PPSG---LVIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRD--- --RHRHPECY--------------------------VCTDCGTNLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYDVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Bos_taurus_RAPGEF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MTTLQIVLQG----PGPWGFRLVGGKDFEQP--------------LAISR---VTPGSKAAIGNLCVG--- --------------------------DVITAIDGENTSNM----THLEAQNKIKGCTDNMTLTVARS------------- ---------------------------------------------------------EQKIWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------ALHIGSAHNRSAVPFTASP---------ASSSA------------------- -------------------------------------------------------------------------------- --------------------------PRVITNQYNNPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISSFNNALESKTAASGQE-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NGRALDHSQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----LPSG---LVIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRE--- --RHRHPECY--------------------------VCTDCGTNLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYDVITVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Equus_caballus_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MTTQQIVLQG----PGPWGFRLVGGKDFEQP--------------LAISR---VTPGSKAATANLCIG--- --------------------------DVITAIDGENTSNM----THLEAQNKIKGCTDNMTLTVTRS------------- ---------------------------------------------------------EHKIWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHIGSAHNRSAMPFTASP---------ASSSA------------------- -------------------------------------------------------------------------------- --------------------------PRVITNQYNNPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNNLLESKTAASGQET------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NGRALDHSQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PPSG---LVIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRD--- --RHRHPECY--------------------------VCTDCGTNLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYDVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Loxodonta_Africana_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MTTQQIVLQG----PGPWGFRLVGGKDFEQP--------------LAISR---VTPGSKAAIADLCIG--- --------------------------DVITAIDGENTSNM----THLEAQNKIKGCTDNMTLTVARS------------- ---------------------------------------------------------EHKIWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHIGSAHNRSAMPFTASP---------ASSST------------------- -------------------------------------------------------------------------------- --------------------------PRVITNQYNNPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNNALEAKTAAIGVET------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NGRPLEYSQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PPSG---LVIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRD--- --RHRHPECY--------------------------VCTDCGTNLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYDVVAVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Myotis_lucifugus_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MTLVKQPPIG----DDPNHSQLLGWEEMNQLP-------------FLITK---VTPGSKAAIANLCIG--- --------------------------DIITAIDGENTSNM----THLEAQNKIKGCVDNMTLTVSRS------------- ---------------------------------------------------------EHKVWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHIGSAHNRSAMPFTASP---------ASGSA------------------- -------------------------------------------------------------------------------- --------------------------PRVITNQYNNPS------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNSALEAKTAAGGPET------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NGRGLEHSQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----SPSG---LVIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRD--- --HHRHPECY--------------------------VCTDCGTNLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYDVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Pteropus_vampyrus_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MTTQQIVLQG----PGPWGFRLVGGKDFEQL----------------ISR---VTPGSKAAVANLCIG--- --------------------------DIITAIDGEDTGNM----THLEAQNKIKGCIDNMTLTVSRS------------- ---------------------------------------------------------EHKVWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHIGSAHNRSAMPFTTSP---------ASSSS------------------- -------------------------------------------------------------------------------- --------------------------PRVITNQYNNPS------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- ISNFNSALESKTAASGPET------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NGRALEHSQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----LPSG---LVIDKESEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRD--- --RHRHPECY--------------------------VCTDCGTNLKQKGHFFVE--------------DQIYCEKHARER VTPPEGYDVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Monodelphis_domestica_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MNTEKIVIQG----PGPWGFRLVGGKDFEQP--------------LAISR---VTPGSKAALANVCIG--- --------------------------DFILAIDGENTSNM----THLEAQNKIKSCVDDITLTVGRS------------- ---------------------------------------------------------EYKIWSPLVTEEG------KRHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VLHVGSAHNRSAMPFSASP---------ASSAS------------------- -------------------------------------------------------------------------------- --------------------------PRVITAQYNNPA------------------------------------------ -----------------------------------------------------------------NLYSSEN-------- ISNFNNALESKTAA-NSEQ------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------NNGILEHSQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PSSN---IGIAKDSEVYKMLQEK---------------------------------------------------- ------------QELNEPP------------KQSTSFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PNKPSGFRSVKA ----PVTKVAASIGN----------AQKLPMCDKCGTGIV-----------------------------GVFVKLRD--- --KYRHPECY--------------------------VCSDCGTNLKQKGHFFVE--------------DCIYCEKHARER VTPPEGYDVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Gallus_gallus_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MGTHRIVLTG----PGPWGFRLVGGRDFEQP--------------LTISR---VTPGSKAAIANLCIG--- --------------------------DQIIAIDGVNTDNM----THLEAQNKIKSCADELTLTVSRT------------- ---------------------------------------------------------ESKVWSPLVNEEG------KAHP YKMNLA-----------SQPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------IRHIGSAHNRSAVPFTA-----------ATASA------------------- -------------------------------------------------------------------------------- --------------------------PKVITAQYNSPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- IQTFNSAVESKTSPGPPEP------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------SKLLDQHS---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----HPSGS---IAIDRDSEVYKMLQEN---------------------------------------------------- ------------QESHEPP------------RQSASFLVLQEILESEE--KGD--------------------------- --------------------------------------------------------------------PSKPSGFRSVKA ----PTTKVAASIGN----------AQKLPMCDKCGSGIV-----------------------------GVFVKIRD--- --KQRHPECY--------------------------VCSDCGTNLKQKGHFFVE--------------DQIYCEKHARER VVPPEGYEVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Taeniopygia_guttata_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------THRIVLSG----PGPWGFRLVGGRDFEQP--------------LAISR---VTPGSKAAIANLCIG--- --------------------------DQIIAIDGVNTDNM----THLEAQNKIKACTDELTLTVSRT------------- ---------------------------------------------------------EAKVWSPLVSEEG------KTHP YKMNLA-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------IRHIGSAHNRSAVPFTA-----------ATASA------------------- -------------------------------------------------------------------------------- --------------------------PRVITAHSELRR------------------------------------------ -----------------------------------------------------------------RHSTSSSPSQVRVGP EQLKHAAQVCPNSPVEVEVPGLKVLHV----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------QFNSPLQL---YSQSNIMDTLQGQISSVSP-------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---DFPSPSKCTIAIDRQSEVYKMLQEN---------------------------------------------------- ------------QESNEPP------------RQSASFLVLQEILESEE--K-D--------------------------- --------------------------------------------------------------------PTKPSGFRSVKA ----PTTKVASSIGN----------AQKLPMCDKCGSGIV-----------------------------GMFVKIRD--- --KQRHPECY--------------------------VCSDCGTNLKQKGHFFVG--------------DQIYCEKHARER VTPPEGYEVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Anolis_carolinensis_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------MSRVLRVAIQG----PGPWGFRLVGGKDFDQP--------------LTISR---VTPGSKAATANLCIG--- --------------------------DTIQAIDGEDTENM----THLEAQNKIKACIDELTLTVYRS------------- ---------------------------------------------------------ESKIWSPLVTEEG------KTNP YKMDLS-----------SEPQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VSNIGSAHNRSAMPFGAT------------STS------------------- -------------------------------------------------------------------------------- --------------------------SKVITAQYNSPV------------------------------------------ -----------------------------------------------------------------NLY-SEN-------- LQTFNNAAESKSVGDLKTS------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------TNLEQPN---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----QLSTN---LRIEKDSEVYKMLQEN---------------------------------------------------- ------------QDSNEPP------------RQSASFLVLQDILESEE--RGE--------------------------- ----------------------------------------------------------------------KPSGFRSVKA ----PTTKIASSIGNA---------AQKLPICDKCGSGIV-----------------------------GVFVKLRE--- --KHLHPECY--------------------------TCSDCGVNLKQKGHFFVE--------------DCIYCEMHARER VTPPEGYEVVAVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Danio_rerio_PDLIM1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MPQRVVLQG----PGPWGFRLVGGKDFEQP--------------LTISR---VTPGSKAAQADLCMG--- --------------------------DMILAIDGESTDGM----THLEAQNKIKACGDEMALSIDRS------------- ---------------------------------------------------------ESKMWSPLVTEDG------KTNP YKMNLAK----------TNTQE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------EKHIGSAHNRSAMPFNS--------------AS------------------- -------------------------------------------------------------------------------- --------------------------PRVVTNQYNNPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- IKNFNSAVDEVQTTAASS-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------EASRNSDPSK---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----PGHT--KAAIAADSEVYKMLQEN---------------------------------------------------- ------------QESNEPP------------RQSASFKVLQEILE-----TGD--------------------------- --------------------------------------------------------------------SEKPSGFRSVKA ----PTTKIGASVGN----------PEKLSLCDKCGSGIV-----------------------------GMIVKLRD--- --KFRHPECY--------------------------VCTDCGINLKQKGHFFVE--------------DQIYCEKHARER ITPPEGYDVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Takifugu_rubripes_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MPLRVVMQG----PGPWGFRLVGGKDFEQP--------------LTISR---VTPGSKAAQANLCIG--- --------------------------DMILAIDGESTEHM----THLEAQNKIKGCIDEMVLSVDRS------------- ---------------------------------------------------------EIKLWSPLSSEGG------KTHP YKMNLE-----------SEPKE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VKHIGSSHNRSALPFG------------------------------------ -------------------------------------------------------------------------------- --------------------------SKVVTNQYNNPA------------------------------------------ -----------------------------------------------------------------GLYSSEN-------- IKDFNSAVDELL-------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------FSKAPSEPTQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MGQ---RPPVAADSEVYKMLQEN---------------------------------------------------- ------------QESDEPP------------RQSASFRVLQEILE-----TGD--------------------------- --------------------------------------------------------------------SDKPSGFRSVKA ----PSTKVGSSVGN----------TQKLPVCDKCGSGIV-----------------------------GAMVKLRD--- --KFRHPECY--------------------------TCTDCDVNLKQKGHFFVE--------------DKIFCEKHARER VVPPEGYDVVTVFPK----------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Gasterosteus_aculeatus_PDLIM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------GRRASDTV PVRCFRDDAAMPLRVVMPG----PGPWGFRLVGGKDFEQP--------------LTISR---VTPASKAAQANLCIG--- --------------------------DMILAIGGEPTEGM----THLEAQNKIKGCIEEMVLSVDRS------------- ---------------------------------------------------------ESKMWSPLSSEEG------RTHP YKMNLA-----------SEPKE---------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------VRHIGSTHNRSALPFAG--------------FG------------------- -------------------------------------------------------------------------------- --------------------------SKVVTNQYNSPS------------------------------------------ -----------------------------------------------------------------ALYSSEN-------- IKDFNSAVDEVQTLAAANEP------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------HSKAPSDLPQ---------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----TGK---RPPVAADSEVYKMLQEN---------------------------------------------------- ------------QESVEPP------------RQSASFKVLQEILE-----TGD--------------------------- --------------------------------------------------------------------PDKPSGFRSVKP ----PATKIGSSVGN----------TEKLPSCDKCGSGIV-----------------------------GMVVKLRD--- --KFRHPECY--------------------------TCTDCNVNLKQKGHFFVE--------------EQIYCEKHARER VTPPEGYDVVTVYPKQNLQLQ----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Oryzias_latipes_PDLIM1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MPLRVVIQG----PGPWGFRLVGGKDFEQP--------------LAISR---VNTGSKAAQANLCIG--- --------------------------DIILAIDGEPTDNM----THLEAQNKIKACGDEMVLSVDRS------------- ---------------------------------------------------------EAKLWSPLSADEG------KSHP YKMNLA-----------SEPR----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------VGVRPSQLAVINSP--------------FG------------------- -------------------------------------------------------------------------------- --------------------------GHILVSSSRSLA------------------------------------------ -----------------------------------------------------------------AAPFSAS-------- WT--SAEISLVLS------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------GRAPSDPSA---------------- --------------------------------------------------------------------------------