>Homo_sapiens_PDE5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------MERAGPSFGQQRQQQQPQQ------QKQQQ------- -------------RDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKE--------------------- -------------GIRGHTESCSCPLQQSPR---------------ADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTV SFLS----DSEKKEQMPLTPPRFD-------------------------------------------------------- ----------------------------------------------HDEGDQCSRLLELVK-DISS---HLDVTALCHKI FLHIHGLISADRYSLFLVCEDSSN--------------------------------DKFLISRLFDVAEGSTLEEVSNN- ----------CIRLEWN--KGIVGHVAALGEPLNIKDAYEDP--------RFN--------------------AEVDQIT GYKTQSILCMPIKNHREE-----VVGVAQAINKKSGN---GG-TFTE-KDEKDF-------------------------- -------------------------------------------------------------------------------- ---AAYLAFCGIVLHNAQ-LYETSL------------LENKRN---QVLLDLASLIFE---------------EQQSLEV ILKKIAAT-IISFMQVQKCTIFIVDEDC-----SDSFSSVFHMECE---------------------------------- --ELEKSSDTLT-REHDAN---------------------------KINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTEN T-----------------GNVNQQCIRS---LLCTPIKNGKKN---KVIG-VCQLVNKMEENT-------GKVKPFNRND EQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLE--VLSYHASAAEEETRELQSLAAAVVPSAQT----------LK- -------------ITDFSFSDFELS-DLETALCTIRMFTDLNLVQNF-------------------------------QM KHE-VLCRWILSVKKN-YRKNVAYHNWRHAFNTAQCMFAALKA---GKIQNKLTDLEILALLIAALSHDLDHRGVNNSYI QR--SEHPLAQLYCHS--IMEHHHFDQCLMILN---SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKR---RGEF FELIR---------KNQFNLE-----------------DPHQK--------------------ELFLAMLMTACDLSAIT KPWPIQQR---IAELVATEFFDQGDRERKELNIEPTD--LMNREKKNKIPSMQ-VGFIDAICLQLYEALTHVSEDCFP-- ------------------------------------------------------------------LLDGCRKNRQKWQA LAEQQEKML----------------------------------------------------------------------- ----------INGESGQAKRN----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Macaca_mulatta_PDE5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------MERAGLSFGRQRQQQQPQQ------QKQQQ------- -------------RDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKE--------------------- -------------GIRGHTESCSCPLQQSPR---------------ADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTV SFLS----DSEKKEQMPLTPPRFD-------------------------------------------------------- ----------------------------------------------HDEGDQCSRLLELVK-DISS---HLDVTALCHKI FLHIHGLISADRYSLFLVCEDSSN--------------------------------DKFLISRLFDVAEGSTLEEASNN- ----------CIRLEWN--KGIVGHVAALGEPLNIKDAYEDP--------RFN--------------------AEVDQIT GYKTQSILCMPIKNHREE-----VVGVAQAINKKSGN---GG-TFTE-KDEKDF-------------------------- -------------------------------------------------------------------------------- ---AAYLAFCGIVLHNAQ-LYETSL------------LENKRN---QVLLDLASLIFE---------------EQQSLEV ILKKIAAT-IISFMQVQKCTIFIVDEDC-----SDSFSSVFHMECE---------------------------------- --ELEKSSDMLT-REHDTN---------------------------KINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTEN T-----------------GNVSQQCIRS---LLCTPIKNGKKN---KVIG-VCQLVNKMEENT-------GKVKPFNRND EQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLE--VLSYHASAAEEETRELQSLAAAVVPSAQT----------LK- -------------ITDFSFSDFELS-DLETALCTIRMFTDLNLVQNF-------------------------------QM KHE-VLCRWILSVKKN-YRKNVAYHNWRHAFNTAQCMFAALKA---GKIQNKLTDLEILALLIAALSHDLDHRGVNNSYI QR--SEHPLAQLYCHS--IMEHHHFDQCLMILN---SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKR---RGEF FELIR---------KNQFNLE-----------------DPHQK--------------------ELFLAMLMTACDLSAIT KPWPIQQR---IAELVASEFFDQGDRERKELNIEPTD--LMNREKKNKIPSMQ-VGFIDAICLQLYEALTHVSEDCFP-- ------------------------------------------------------------------LLDGCRKNRQKWQA LAEQQEKML----------------------------------------------------------------------- ----------INGESGQAKRN----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Mus_musculus_PDE5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------MERAGPNSVRS----------------QQQ------- -------------RDPDWVEAWLDDHRDFTFSYFIRKATRDMVNAWFSERVHNIPVCKE--------------------- -------------GIRAHTESCSCSLQQSPH---------------ADNTTPGAPARKISASEFDRPLRPIVVKDSEGTV SFLS----DSGKKEQMPLTPPRFD-------------------------------------------------------- ----------------------------------------------SDEGDQCSRLLELVK-DISS---HLDVTALCHKI FLHIHGLISADRYSLFLVCEDSSK--------------------------------DKFLISRLFDVAEGSTLEEASNN- ----------CIRLEWN--KGIVGHVAAFGEPLNIKDAYEDP--------RFN--------------------AEVDQIT GYKTQSILCMPIKNHREE-----VVGVAQAINKKSGN---GG-TFTE-KDEKDF-------------------------- -------------------------------------------------------------------------------- ---AAYLAFCGIVLHNAQ-LYETSL------------LENKRN---QVLLDLASLIFE---------------EQQSLEV ILKKIAAT-IISFMQVQKCTIFIVDEDC-----PDSFSRVFHMECE---------------------------------- --EVGKPSDPLT-REQDAN---------------------------KINYMYAQYVKNTMEPLNIPDVTKDKRFPWTNEN M-----------------GHVNTPCIGS---LLCTPIKNGKKN---KVIG-VCQLVNKMEENT-------GKIKAFNQND EQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLE--VLSYHASAAEEETRELQALSAAVVPSAQT----------LK- -------------ITDFSFSDFELS-DLETALCTIRMFTDLNLVQNF-------------------------------QM KHE-VLCRWILSVKKN-YRKNVAYHNWRHAFNTAQCMFAALKA---GKIQNKLTDLETLALLIAALSHDLDHRGVNNSYI QR--SEHPLAQLYCHS--IMEHHHFDQCLMILN---SPGNQILSGLSIDEYKTTLKIIKQAILATDLALYIKR---RGEF FELIR---------KNQFSFE-----------------DPLQK--------------------ELFLAMLMTACDLSAIT KPWPIQQR---IAELVAAEFFDQGDRERKELNMEPAD--LMNREKKNKIPSMQ-VGFIDAICLQLYEALTHVSEDCLP-- ------------------------------------------------------------------LLDGCRKNRQKWQA LAEQQEKML----------------------------------------------------------------------- ----------LNGESSQGKRD----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Felis_catus_PDE5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------MVNAWFAERVHTIPVCKE--------------------- -------------GIRSHTESCSCPSQQSPR---------------ADSSAPGTPTRKISASEFDRPLRPIVVKDSEGTV SFLS----DSEKKEQMPLTPPRFD-------------------------------------------------------- ----------------------------------------------NDEGDQCSRLLELVK-DISS---HLDVTALCHKI FLHIHGLISADRYSLFLVCEDSSN--------------------------------DKFLISRLFDVAEGSTLEEASNN- ----------CIRLEWN--KGIVGHVAAFGEPLNIKDAYEDP--------RFN--------------------AEVDQIT GYRTQSILCMPIKNHREE-----VVGVAQAINKRSGN---GG-TFTE-KDEKDF-------------------------- -------------------------------------------------------------------------------- ---AAYLAFCGIVLHNAQ-LYETSL------------LENKRNQA-KVLLDLASLIFE---------------EQQSLEV ILKKIAAT-IISFMQVQKCTIFIVDEDC-----SDSFSSVFHMECE---------------------------------- --ELEKSSDTLT-RERDAN---------------------------RINYMYAQYVKNTMEPLNIPDVSKDKRFPWTNEN T-----------------GSVSQQFIRS---LLCTPIKNGKKN---KVIG-VCQLVNKMEENT-------GKVKPFNRND EQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLE--VLSYHASAAEEETRELQSLAAAVVPSAQT----------LK- -------------ITDFSFSDFELS-DLETALCTIRMFTDLNLVQNF-------------------------------QM KHE-VLCRWILSVKKN-YRKNVAYHNWRHAFNTAQCMFAALKA---GKIQNKLTDLETLALLIAALSHDLDHRGVNNSYI QR--SEHPLAQLYCHS--IMEHHHFDQCLMILN---SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKR---RGEF FELIR---------KNQFNLE-----------------DPHQK--------------------ELFLAMLMTACDLSAIT KPWPIQQR---IAELVATEFFDQGDRERKELNIEPAD--LMNREKKNKIPSMQ-VGFIDAICLQLYEALTHVSEDCFP-- ------------------------------------------------------------------LLDGCRKNRQKWQA LAEQQEKML----------------------------------------------------------------------- ----------INGESSQAKRN----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Gallus_gallus_PDE5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MERSCHPSPEQEAVEAWLDDHCDFTRSYFVRKATREMVNAWFAERVHTIPVCKE--------------------- -------------GTKSQSE--SCACQQLAC---------------SENTNSGTPARKISASEFDRPLRPIFVKDSVGAV SFLS----GSEKKEQMPLQSPRTG-------------------------------------------------------- ----------------------------------------------TSAGDRCSRLLELVK-DISS---HLDVTALCHKI FLHIHELIAADRYSLFLVCEDSSN--------------------------------EKFLVSRLFDVAEGSTLEEASNN- ----------CIRLEWN--KGIVGHVAAIGQPLNIKNAYEDP--------RFN--------------------AEVDQIT GYKTQSILCMPIKNHREE-----VVGVAQAINKKSGT---GG-TFTE-QDEKDF-------------------------- -------------------------------------------------------------------------------- ---AAYLAFCGIVLHNAQ-LYETSL------------LENRRN---QVLLDLASLIFE---------------EQQSLEV ILKKIAAT-IISFMQVQRCTIFIVDEDC-----TDSFSSVFHMEAE---------------------------------- --ELEDSAENQK-RDCDTN---------------------------KINYMYAQYVKNTMEPLNIPDVCKDRRFPWTTDS A-----------------ESVSQHIKS----LLCTPIKNGKKN---KVIG-VCQLVNKMEENS-------GKIKAFNRND EQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLE--VLSYHASAAEEESRELQVTAAAVVPSAQS----------LN- -------------LTDFNFSDFELS-DFETTLCTIRMFTDLNLVQNF-------------------------------QM KHE-VLCRWILSVKKN-YRKNVAYHNWRHAFNTAQCMFAALKS---GKIQSKLTDLETLALLIATLSHDLDHRGVNNSYI QR--SEHPLAQLYCHS--IMEHHHFDQCLMILN---SPGNQILSSLSIEEYKATLKMIKQAILATDLALYIKR---RGEF FELLR---------KKQFNWE-----------------DPMQK--------------------ELFLAMLMTACDLSAIT KPWPVQQR---IAELVATEFFDQGDKERKELNIEPTD--LMNREKKNKIPSMQ-VGFIDAVCLQLYEALTHVSEACYP-- ------------------------------------------------------------------LLDGCRKNRQKWQS LAEQQEKNL----------------------------------------------------------------------- ----------INGESNQAKRN----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Anolis_carolinensis_PDE5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------KAWILLFWDFLLNLLRERRGREMVNAWFSERVHTIPVCKE--------------------- -------------GTKTHSETCSCSTLQTTR---------------SENTNSTPPARKISASEFDRPLRPIVVKDSIGTV SFLS----DSEKKEQMPLQSRTLR-------------------------------------------------------- ----------------------------------------------TDAGDQCTRLLELVK-DISS---HLDVTALCHKI FLHIHELIAADRYSLFLVCEDSSN--------------------------------EKFLVSRLFDVAEGTTLEEASNN- ----------CIRLEWN--KGIVGHVAALGQPLNIKDAYEDP--------RFN--------------------AEVDQIT GYKTQSILCMPIKNHREE-----VVGVAQAINKKSGG---GG-TFTE-QDEKDF-------------------------- -------------------------------------------------------------------------------- ---SAYLAFCGIVLHNAQ-LYETSL------------LENRRN---QVLLDLASLIFE---------------EQQSLEV ILKKIAAT-IISFMQVQQCTIFIVDEDC-----SDSYSSVFHMEFE---------------------------------- --ELEDSNETHK-RDYDTN---------------------------QINYMYAQYVKNTMEPLNIPNIRQDKRFPWTPFN V-----------------NNVNAQKVCPKQLLLTTEKELGEKNETPNDPG-VCQLANKMEENS-------CKIKAFNRND EQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLE--VLSYHASAADEEARELQVTAAAVVPSAQS----------LG- -------------LTDFYFSDFELS-DMETSLCTIRMFTDLNLVQNF-------------------------------QM KHE-VLCRWILSVRKN-YRKNVAYHNWRHAFNTAQCMFAALKS---GKIQNKLTDTEVLSLLIAALSHDLDHRGVNNSYI QR--SEHPLAQLYCHS--IMEHHHFDQCLMILN---TPGNQILSGLSVEEYKATVKMIKQAILATDLALYIKR---RGEF FDLLR---------KKQFNLE-----------------DPYQK--------------------ELFLAMLMTACDLSAIT KPWPVQQRKTQIAELVAAEFFDQGDKERQELNIEPTD--LMNREKKNKIPSMQ-VGFIDAICLQLYEALTHISEACYP-- ------------------------------------------------------------------LLEGCRKNRQKWQA LAEQQENNL----------------------------------------------------------------------- ----------INGESNQPKRN----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Xenopus_tropicalis_PDE5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------Q-----VVGVAQAINKKSGS---NG-TFTD-QDEKDF-------------------------- -------------------------------------------------------------------------------- ---AAYLAFCGIVLHNAQ-LYETSL------------LENRRN---QVLLDLATLIFE---------------EQQSLEV ILKKIAAT-ILSFMQAQRCTIFIVDEDS-----PDTFSSVFHMESD---------------------------------- --ELEESADAVK-REYDVS---------------------------KMNYMYAQYVANTMEAINIPDICKDTRFPWTNGN ------------------EEKNFKHIQS---LLCSPIKNAKKN---KVIG-VCQLVNKVDENS-------GKIKAFNKND EQFLEAFAIFCGLGIQNTQMFEVVERAMAKQMVTLE--ILSYHASAAEEETMELQVTAGAIVPSAQS----------LK- -------------LTEFYFSDFELS-DMETTLATSRMFTDLNLVQTF-------------------------------QM KYEKTLCRWILSVKKN-YRKNVAYHNWRHAFNTAQCMFAALRT---GKIQGKLNDLEILALMIATLSHDLDHRGVNNSFI QR--SEHPLAQLYCHS--IMENHHFDQCLMILN---SQGNQILSGLSVQDYKTVLKMIKQAILATDLALYIKR---RSDF FELVN---------KKKFKWD-----------------DPSQK--------------------ELFLAMLMTACDLSAIT KPWPVQQR---IAELVASEFYDQGDKERRELNIEPID--LMNREKKDKIPSMQ-VGFIDAVCLELYEALTQISESCYP-- ------------------------------------------------------------------LLDGCQRNRQMWQI LAEQQEKNL----------------------------------------------------------------------- ----------VNGAKSQPEVKCNMD------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Danio_rerio_PDE5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MEVYPSDSERMMEAWLDDNLEFAHSYFVRKASREMVNAWFAERVHSIQPSRE--------------------- -------------PSKAVPEPVTAVHSLGPT-----------DVVPSSSPAPSTPTRKISASEFDRPLRPIVVKDAEGSF TFLS----DTER-VQMPLPPSQRPGSDNGTD------------------------------------------------- -------------------------------------EGG--GIRDRGNGDRCARLLELVR-DVSS---HLDLTALCHKI FLHTHELIAADRYSLFLVGEDSSN--------------------------------RKFLVSRLFDVAEGSTLEESSNS- ----------GIRLEWN--KGIVGYVAATGQPLNIKNAYEDS--------RFN--------------------AEVDQIT GYKTQSILCLPIKNHRDE-----VVGVAQAINKKCGE---NS-TFTE-QDEKDF-------------------------- -------------------------------------------------------------------------------- ---SSYLAFSGIVLHNAQ-LYETSQ------------LENRRN---QVLLDLASLIFE---------------EQQSLEV LLRKTVAT-ILSFMQAQECTVFISDRET-----ANTFASVFHMEYE---------------------------------- --EIAGSTDFPN-RECDVN---------------------------KINYMYAQYVKNTMETLNITDTTKDQLFSWTSED P-----------------QSTNCQ-IKS---LLCTPIRNGKKD---KVIG-VCQLVNKMDEAS-------GEVKAFNRND EQFLEAFAVFCGLGIQNTQMYEAVERAMAKQEVTLE--VLSYHASAAEEETRALQVTAAATIPSAQS----------LR- -------------LMDYSFSDFDLT-DAETTQATIRMFVDLKLVQNF-------------------------------QI KYK-SLCQWILSVKKN-YRKNVVYHNWRHAFNTSQCMFAVLKS---GRVQNNLSDLETLALMIATLSHDLDHRGVNNSYI KR--SDHPLAQLYCHS--TMEHHHFDQCLMILN---SPGNQILSGLSLDEYKATLKMIEKAILATDLAVYMKK---RTEF FELAK---------NSQFEWE-----------------DDCHR--------------------DLLRSMLMTACDISAIT KPWPVQKK---IAELVATEFFEQGDKERRELNIEPID--LMNREKQDKIPSMQ-VSFIDAICTQLYEALTGISEFCSP-- ------------------------------------------------------------------LLEGCRKNRQNWKI LAEQGEEAA----------------------------------------------------------------------- ----------LLNGEL---------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Takifugu_rubripes_PDE5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------ESERMEAWLDDHLEFTRSYFIRKASREMVNAWFAERVHSIHPSAP--------------------- -------------KEN-PPQHPRTQQSSADS------------AVTAPSPVPGTPTRKISASEFDRPLRPIVVKDAEGSL TFLS----DADR-ETVPVR-AAAMGEGGGVH------------------------------------------------- -------------------------------------VGGCDEAGSWCGRDRCARLLELVK-EVSS---HLDVTALCHKI FLHINELIAADRYSLFLVGEDSSN--------------------------------RKFLVSRLFDVAEGSTVEESSSS- ----------CIRLEWN--KGIVGHVAATGQPLNIKNAYEDS--------RFN--------------------AEVDLIT GYKTHSILCLPIKNHRDE-----VVGVAQAINKKSGD---DA-AFTD-QDEKDF-------------------------- -------------------------------------------------------------------------------- ---SAYLAFSGIVLHNAQ-LYETSQ------------LENRRN---QVLLDLASLIFE---------------EQQCLKV LLRKFAGT-ILSFMQAQACTVFIADEDS-----MNSFSSVFHMEYE---------------------------------- --ELGEVLDVPK-RDCDVS---------------------------QINYMYAQYVKNTMQTLNIADVTKDQRFPWTGEN P-----------------DHTNDQ-IKS---LLCTPIRNGKKD---KVIG-VCQLVNKMDEAS-------DSVKAFNRND EQFLEAFAIFCGLGIQNTQMYETVERAMAKQEVTLE--VLSYHATASEEESRELQVTVVATVPSAQS----------LR- -------------LLDFSFSDFELS-DTETTLATIRMFVDLNLVQNF-------------------------------QM KYM-NLCRWVLSVKKN-YRKSVAYHNWRHAFNTAQSMFALLKS---GRLQNNLNDLEVLALMIATLSHDLDHRGVNNSYI QR--SDHPLAQLYCHS--TMEHHHFDHCLMILN---SPGNQILSSLSLDEYKSTLKMIERAILATDLALYMKR---RGEF FELTK---------NSQFVWE-----------------DEQHR--------------------DLLRSMLMTACDISAIT KPWPVQQR---IAELVATEFFEQGDKERRELNIEPSD--LMNREKKDKIPSMQ-VSFIDAICTQLYETLAGMSEYCSP-- ------------------------------------------------------------------LLEGCQKNRQQWKH LAEECEKG------------------------------------------------------------------------ ----------LVNG------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Oryzias_latipes_PDE5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----SLCQWILSVKKN-YRKSVAYHNWRHAFNTAQCMFALLKS---GRLQNNLSDLEILALMIATLSHDLDHRGVNNSYI QR--SEHPLAQLYCHS--TMEHHHFDQCLMILN---TPGNQILSGLSLDEYKATLKMIEKAILATDLALYMKK---REDF FELTK---------NNQFVWV-----------------DEHHR--------------------DLLRSMLMTACDISAIT KPWPVQKR---VAELVATEFFEQGDKERRELNIEPTD--LMNREKRDKIPSMQ-VSFIDAICIQLYETLAGLLEHCSP-- ------------------------------------------------------------------LLEGCQKNRQHWKR LAEDCEK------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Ciona_intestinalis_PDE5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------ESVLLLELAREISDTD----DQDKFCFQA LRHVVSIVNAEKCSLFWMRDSAKGDSK-------------------------------ELASRLWNITPKSTFDDVVCD- ---------SKNELVVPVGVGIAGLVAETKEAVIVSNVYE-HPNFN---------------------------KTIDEKT GFESRDLLCQPLVLKREDK----VVGVVEVVNKKNKEP------FTTEDAQVLE-------------------------- -------------------------------------------------------------------------------- ----HFLVLCNLAIQNCRGAAQITR------------LQQAAT---VSFLWQVN----ILFVG-----------LSYYRI RFHKEVVMQISDLIQCERYTLAIALIDNCNIEGCLQFAKSYDLLLQKPKASMFDDEDQPIV------------------K TVEVNNIAGYIFIYKKKQQSITN-----------------GIADVLRFLSMHSTLTAANCTKTLLNDICFIFMFEECKLL DDAK-----------------KEFSLKS---ALCVAFYDGTDR-----LLGVLHLGNKK-------------KKGFDEND EAVIQSVRPYIMNGLLFANGFNSIVINKAKTDVAED--TVRFHIRPWQDEVDRVVVSLAVYGNRKWSLIIMDAAFFSQNE PIP-EGEKYN---LYQFTFSDLLMS-DDETVMGAMRMFLDLDAFNLF-------------------------------HI RQE-TMLRWLITTRRC--YRPVYYHNWRHGLNVAHTMFLLLDR-MTPGIDKAFNDREKFALVVACFCHDIDHRGTNNAFL IR--AGAPLAILYNTS--TLENHHYDTCLRISS---IDGNNIFESFTKEQFESACELMKHAILATDLALYFQR---RNTF KKLLEKPFEERD-------FVQ----------------NNDNR--------------------MLLMSMMMTACDLSSIT KPWEVQQK---MAKLVTSEFYDQGDQERALFGTEPMP--MMDRRKIDDLPKMQ-IGFIDGVCSMAYEMMADFCPGYAP-- ------------------------------------------------------------------LRDGMRANRQSWKD LASE---------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Ciona_savignyi_PDE5A -------------------------------------------------------------------------------- --------------------------MATEAQLN---------------------------------------------- -------------------------------------------------------------------------------- ---------------RELVEAWLDDHAEFAFDYFTRKATQTMVNTWLADRVIRIAGSDRKIS--------------S--- ------------IERSPTKHDNDPTIRPPSTSGD--------------STGRKTPIRKISHEEIKPGHLPLKPMVLTDEM GSPS----FYTPDSATSPSLTRR--------------------------------------------------------- ------------------------------------------------MNNQRDMIMDLVI-DIAS---DLDVTSVSHRI LQNVSILVDADRCSLFLMRER----------------DGEK-----------------FLVSRLFNVSKESTLEDNVVV- --------KDEIKMKLG--QGIAGMVALTGTTLNIPDAYKDH--------RFN--------------------QSVDKKT GYRTRSILCMPIRDGDKR-----IVGVAQVINKTEG-------AFTS-KDEKIF-------------------------- -------------------------------------------------------------------------------- ---ASYLGFCGVAIHNAQ-IFEKVQ------------LENRRN---EILLDLARVLFE---------------EQSSLST VMDTILTH-TVSLLSCERASVLLANPSQP----ENVFEHTFEHVDES--------------------------------- --TITSNLNFDKNSPQRNK--------------------------VPLNIAITSYVRQTGQIVNIENASSDQRFEFLEDT --------------------ELGFTTRS---LLCIPIWDSFRQ----VIG-VIQLINKHHRV----------GPRFTKSD EQILEAFAIFCGLGISNTRMYEETARLAAKQQVILE--VLSYHAVASPLETNALLT---NDIPSSKS----------LG- -------------ILKYEFDDTTLS-DLDTVRASVRMFIDLKLVEKF-------------------------------RI NHE-TLCRWVASVKRN-YR-PVSYHNWRHAFNVCQSCFCMVK--TGG-LDTVFSDFEKLALLVSCLSHDLDHRGTNNAFQ AK--IEHPLARLYSTS--TMEHHHYNQCLMLLQ---SDGCEILSHLSSTEYAQVIKLIQHAILSTDLAIYFKK---RGEF FNILR---------SENADWKG----------------NDSHR--------------------ELLRSLVITGCDIAGIT RPWKVQKEI---AQLVAEEFFEQGDIEKTKLHQEPPD--MMNRKLKHKLPKMQ-IGFIDSICLPLYEALSDVEPGLQP-- ------------------------------------------------------------------LLNGCLDNRRHWE- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Caenorhabditis_elegans_PDE5A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MDDASVLKYLQENPKLVEDFVVSNEISPETFKRWAVRRTMKYKN----------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------VKNGTSGGTGAWTEPDLSMKR-------------------- ----------------------------------------------------------------------RVILETSDNR --------TRILYEITQCCGQLIGTNSIELIVQNDEGAFSCRK---------------------------TENGELKLKK VKTSKSADYIQTIVN---------AGNQTIAEIHFYTQ------LDSTEKSIVN-------------------------- -------------------------------------------------------------------------------- ----AVCTWAAATNYYSELYTHKQEGSDGQDIHENIAKQRKLS---NFLLDVARSIFH---------------DIVSMDA VIIKVMNF-AQKLVDADRASLFLVDSKNA-----QIYARIFD-------------------------------------- -VGTGDEEHVRVNSEGQK------------------------EIRFDMSKGIAGYVASTGEGLNIENAYEDERFNADVDS K--------------------TGYTTKT---ILCMPILIRGIVIG------VVQMVNKHDG----------VFT---RQD EDAFEIFAVYCGLALHHAKLYDKIRRSEQKYRVALE--VLAYHSVCNADEVNKLKK-IEINNRIVE-------------- ----------------LETIDFNGM-RLSELEKPLYAVYMFKTLFA------------------------------DTLR FDTEDLIRFVLTVRKN--YRRVAYHNWAHGWSVAHAMFATLM-----NSPDAFTKLEALALYVSCLCHDLDHRGKNNAYM KT--MSTPLASIYSTS--VMERHHFNQTVTILQQ---DGHNILKSLSSEDYKKTLSLIKHCILATDLALFFSN---KAKL NVILD---------NNTFDIN-----------------RQEHR--------------------LLTQAVMMTGCDLVASA KPWNIQTET---VKVIFEEFYDQGDAERLSGKEP-IP--MMDRQQAHMLPQMQ-VGFMRGICMPCYDLIARIFPKNDK-- ------------------------------------------------------------------MRERCEYNAKKWEE LAEEQR-----------------------KKQEALAQQ------------------------------------------ -------NGEANETQE---------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Nematostella_vectensis_PDE5A -------------------------------------------------------------------------------- -------------------------------MINLEDAS----------------------------------------- -------------------------------------------------------------------------------- --------------TEQKVESWLDEHPEFVQSYFARKANRSLVDSWLHSRSHARTPSGT-----------------P--- ------------PP-----------------SG------------------SSTPVRKISASEFEGRGILKP--LVNVVD GQLS----FLSPSEPSRKRSTAH--------------------------------------------------------- --------------------------------------RNRKSRLELQQLDEKEVLMELVK-DISN---DLDVQSLCHKI LQNVSILLNADRCSLFLCQGP---------------KEGPR-----------------FLVSKVFDVNAESKLED-VQC- --------LEEIRIPWG--TGIVGYVAETGETVNIPNAYEDA--------RFN--------------------KEIDKKT GYTTRSILCMPIKDHDGE-----VIGVAQVINKTGKSTD---SAFTI-DDEQIF-------------------------- -------------------------------------------------------------------------------- ---LKYLVFCGIGINNAE-LYERAQ------------LEIRRN---QVLLDLARTIFE---------------EQTSLHN IVHKIMMI-TQSLLQCERCSVLLVDPTS-----KTLFAQAFD-LEAK--------------------------------- --DYLQNDDDDKTV--EVR--------------------------FPINIGITGHVATTGETLNIPDAYADERFDPTVDQ --------------------VSGFTTKT---ILCMPIKNASGD----IIG-VVQLLNKVD------------GTPFNKND ENLFEAFAIFCGMAIHSTVMYENVNKAMAKRKVALE--VLSYHAVSPLEEAIKLKE---EPLPPITS----------LR- -------------LIDFAFDDMSIS-DDDTLKGCLAMLCDLKIVETF-------------------------------QI DYL-TLCRFVLTIKKN-YR-PVMYHNWRHAFNVAQTMYAMLK--KPS-IGKYFTVIEQYALIVACLSHDLDHRGTNNSFQ IK--SATPLAQLYSTS--TMEHHHFDQCIMIIN---SQGNEIFNTLSADEYNKIIKLLEASIIATDLALYFQR---RGDF FKKVE---------NRELDWS-----------------DDSSK--------------------DLLRAMMMTACDLSAIT KPWLVQKRT---AHLVAEEFFQQGDLEQEELHSTPLP--TMDRRKKDELPQMQ-VGFIDAVCLPLYKAFSQFDDNLKV-- ------------------------------------------------------------------LKDGCRENRRQWQK LAEDHK-------------------------------------------------------------------------- ----------AREVSCRTRV------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Homo_sapiens_PDE6B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAAC-E-DGCPPDCDS--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------LRDLCQVEESTALLELVQDMQES----INMERVVFKV LRRLCTLLQADRCSLFMYRQ--RNGVA-------------------------------ELATRLFSVQPDSVLEDCLVP- ---------PDSEIVFPLDIGVVGHVAQTKKMVNVEDVAE-CPHFS---------------------------SFADELT DYKTKNMLATPIMNGKD------VVAVIMAVNKLNGPF------FTSEDEDVFL-------------------------- -------------------------------------------------------------------------------- ----KYLNFATLYLKIYH-LSYLHN------------CETRRG---QVLLWSAN----KVFE-----------ELTDIER QFHKAFYT-VRAYLNCERYSVGLLDMTKE-----KEFFDVWS-VLMGESQPYSGPRTPDG-------------------R EIVFYKVIDYVLHGKEEIK-VIP----------------TPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQE-G ALDD-----------------SGWLIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEQD EVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQD--MVLYHVKCDRDEIQLILPTRARLGKEPAD-CDEDELGEILKE ELP-GPTTFD---IYEFHFSDLECT-ELDLVKCGIQMYYELGVVRKF-------------------------------QI PQE-VLVRFLFSISKG--YRRITYHNWRHGFNVAQTMFTLL---MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQ MK--SQNPLAKLHGSS--ILERHHLEFGKFLLS---EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKK---RAMF QKIVDESKNYQDKKSWVEYLSL----------------ETTRK--------------------EIVMAMMMTACDLSAIT KPWEVQSK---VALLVAAEFWEQGDLERTVLDQQPIP--MMDRNKAAELPKLQ-VGFIDFVCTFVYKEFSRFHEEILP-- ------------------------------------------------------------------MFDRLQNNRKEWKA LADEYEAKVKALEE-KE-EEERVAAKKVGTEICN-------GGPAP---------------------------------- -----------KSSTCCIL------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Macaca_mulatta_PDE6B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAAC-E-DRCPPDCNS--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------FRELCQVEESEALLELVQDMQEN----INMERVVFKV LRRLCTLLQADRCSLFMYRQ--RNGVA-------------------------------ELATRLFSVQPDSVLEDCLVP- ---------PDSEIVFPLDIGVVGHVAQTKKMVNVKDVAEQCPHFS---------------------------SFADELT DYKTKNILATPIMNGKD------VVAVIMAVNKLNGPF------FTSEDEDVFL-------------------------- -------------------------------------------------------------------------------- ----KYLNFATLDLKIYH-LSYLHN------------CETRRG---QVLLWSAN----KVFE-----------ELTDIER QFHKAFYT-VRAYLNCERYSVGLLDMTKE-----KEFFDVWP-VLMGESQPYSGPRTPDG-------------------R ELGHSPLHTHVQPGLVPLTPAHT----------------TPPADHWALASGLPSYVAESGFVSPVLSGAPTALPSLGE-G ALDD-----------------SGWLIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEQD EVLMESLTQFLGWSVMNTDTHDKMNKLENRKDIAQD--MVLYHVKCDRDEIQLILPTRARLGKEPAD-CDEDELGEILKE ELP-GPTTFD---IYEFHFSDLECT-ELDLVKCGIQMYYELGVVRKF-------------------------------QI PQE-VLVRFLFSISKG--YRRITYHNWRHGFNVAQTMFTLL---MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQ MK--SQNPLAKLHGSS--ILERHHLEFGKFLLS---EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKK---RAMF QKIVDESKNYEDKKSWVEYLSL----------------ETTRK--------------------EIVMAMMMTACDLSAIT KPWEVQSK---VALLVAAEFWEQGDLERTVLDQQPIP--HVDQNKAAELPKLQ-VGFIDFVCTFVYKEFSRFHEEILP-- ------------------------------------------------------------------MFDRLQNNRKEWKA LADEYEAKVKGVGR-GHTKQEGTN-RAVGTEICN-------GGPAP---------------------------------- -----------KSSTCCIL------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Mus_musculus_PDE6B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MSLSEEQVRSFLDGNPTFAHQYFGKKLSPENVAGAC-E-DGWLADCGS--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------LRELCQVEESAALFELVQDMQES----VNMERVVFKI LRRLCTILHADRCSLFMYRQ--RNGIA-------------------------------ELATRLFSVQPDSLLEDCLVP- ---------PDSEIVFPLDIGIVGHVAQTKKMINVQDVAE-CPHFS---------------------------SFADELT DYVTKNILSTPIMNGKD------VVAVIMAVNKLDGPC------FTSEDEDVFT-------------------------- -------------------------------------------------------------------------------- ----KYLNFATLNLKIYH-LSYLHN------------CETRRG---QVLLWSAN----KVFE-----------ELTDIER QFHKAFYT-VRAYLNCERYSVGLLDMTKE-----KEFFDVWP-VLMGEAQPYSGPRTPDG-------------------R EIVFYKVIDYILHGKEDIK-VIP----------------TPPADHWALASGLPTYVAESGFICNIMNASADEMFNFQE-G PLDD-----------------SGWVIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDDQD EVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQD--MVLYHVRCDKDEIQEILPTRDRLGKEPAD-CEEDELGKILKE ELP-GPTKFD---IYEFHFSDLECT-ELELVKCGIQMYYELGVVRKF-------------------------------QI PQE-VLVRFLFSVSKA--YRRITYHNWRHGFNVAQTMFTLL---MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQ MK--SQNPLAKLHGSS--ILERHHLEFGKFLLA---EESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKK---RTMF QKIVDESKNYEDKKSWVEYLSL----------------ETTRK--------------------EIVMAMMMTACDLSAIT KPWEVQSK---VALLVAAEFWEQGDLERTVLDQQPIP--MMDRNKAAELPKLQ-VGFIDFVCTFVYKEFSRFHEEILP-- ------------------------------------------------------------------MFDRLQNNRKEWKA LADEYEAKVKALEEEKKKEEDRVAAKKVGTEVCN-------GGPAP---------------------------------- -----------KSSTCCIL------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Felis_catus_PDE6B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MSLSGEQVQQFLDQNPSFADEYFGKKLSPENVAGAH-E-DGQPVDCAS--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------FRELCQVEESTALFELVQDMQES----VNMERVVFKI LRRLCTILHADRCSLFMYRQ--RNGVA-------------------------------ELATRLFSVQPGSVLEDCLVP- ---------PDSEIVFPLDIGVVGHVAQTKKMVNIKDVTE-CPHFS---------------------------SFADELT DYVTKNILATPIMNGKD------VVAVIMAVNKLDGPC------FTSEDEDVFL-------------------------- -------------------------------------------------------------------------------- ----KYLNFGTLNLKIYH-LSYLHN------------CETRRG---QVLLWSAN----KVFE-----------ELTDIER QFHKAFYT-VRAYLNCDRYSVGLLDMTKE-----KEFFDVWP-VLMGEAQPYSGPRTPDG-------------------R EIVFYKVIDYILHGKEDIK-VIP----------------TPPADHWALASGLPTYVAESGFICNIMNAPADEMFKFQE-G PLDD-----------------SGWTIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEQD EVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQD--MVLYHVRCDKDEIQLVLPTRERLGKEPAD-CEEDELGTILKE VLP-GPNKFD---IYEFHFSDLECT-ELELVKCGIQMYYELGVVRKF-------------------------------QI PQE-VLVRFLFSVSKG--YRRITYHNWRHGFNVAQTMFTLL---MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQ MK--SQNPLAKLHGSS--ILERHHLEFGKFLLS---EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKK---RTMF QKIVDESKNYEDRKSWVEYLSL----------------ETTRK--------------------EIVMAMMMTACDLSAIT KPWEVQSK---VALLVAAEFWEQGDLERTVLDQQPIP--MMDRNKAAELPKLQ-VGFIDFVCTFVYKEFSRFHEEILP-- ------------------------------------------------------------------MFDRLQNNRKEWKA LADEYEAKVKALEEEKQQQEERTTVKKGGTEICN-------GGPAP---------------------------------- -----------KSSTCCIL------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Gallus_gallus_PDE6B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MSISEDDVEKFLDGNPAFAKQYFEKKLKTESCDDN---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------ESEILFELIQDMQES----INMEKVVFKT LRRIRSLIHADRCSLFMYRQ--RNGTP-------------------------------ELATRLFNIQEGSTLEECLVS- ---------PDCEIVYPLDLGIVGYVAQTKKTMNIKDVSE-CPQFS---------------------------SFVDELT DYTTKSILATPILNGKD------LVAVILAINKLNGPF------FTNSDETLFL-------------------------- -------------------------------------------------------------------------------- ----KYLNFASLNLKIYH-LSYLHN------------CETRRG---QVLLWSAN----KVFE-----------ELTDIER QFHKAFYT-VRAYLNCDRYSVGLLDMTKQ-----KEFFDLWP-VLLGEVPPYSGPRTPDG-------------------R EIVFYKVIDYILHGKEDIK-VIP----------------NPTPDHWALVTGLPTYVAESGFICNIMNAAADEMFNFQE-G PLDE-----------------SGWTIKN---VLSMPIVNKKEE-----IVGVVTFFNRKD------------GKPFDEQD ETLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQD--MVLYHVKCDKDEIQEILPTREKLGKEPSE-CEEEELASILKE QLP-GPTKFE---IYEFRFSDFDCT-ELELVKCGIQMYYELGVVKKF-------------------------------QI PQE-VLVRFVYSVSKG--YRKITYHNWRHGFNVAQTMFTLL---MTGKLKRYYTDLEAFAMVTAALCHDIDHRGTNNLYQ MK--SQNPLAKLHGSS--ILERHHLDFGKFLLS---EESLNICQNLNRRQHEHMIHLMDIAIIATDLALYFKK---RTMF QKIVDESKTYDNTTAWTDYLSL----------------ETTKK--------------------EVVMAMMMTACDLSAIT KPWEVQSK---VALLVAAEFWEQGDLEISVLQQQPIP--MMDRRKAAELPKLQ-VGFIDFVCTFVYKEFSRFHEEIQP-- ------------------------------------------------------------------MLDGLLNNRNEWKT RADEYDAKMKALEEEKKKEEEKMAAQKDGIT-CN-------GGTAP---------------------------------- -----------TSKTCSIL------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Anolis_carolinensis_PDE6B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MSVNKDEVETFLDNNLDFAKQYFERKLGDKTLCATA-S-FHQCSEDGV--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------DFGGLGQNETETLFELIQDMQES----INMEKVVFKT LKRISVLIQADCCSLFMYRQ--RNGTP-------------------------------ELATRLFNIRKDSTMEESLVA- ---------PDCEIVFPLDMGIVGYVAQNKKTVNIQNVDE-CDYFS---------------------------TFVDELT GYTTRNVLATPIMNGKE------VVAVIMAVNKSGAQF------FSSADENLFL-------------------------- -------------------------------------------------------------------------------- ----KYLNFAALNLKIYH-LSYLHN------------CETRRG---QVLLWSAN----KVFE-----------ELTDIER QFHKAFYT-VRAYLNCDRYSVGLLDMSKQ-----KEFFDLWP-VLMGEVPPYSGPRTPDG-------------------R EIAFYKVIDYILHGKEDIK-VIP----------------NPKPEHWALVSGLPTYVAETGFICNIMNAASDEMFAFQE-G PVDE-----------------SGWVIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEQD EILMESLTQFLGWSVLNTDTYDKMNKLEYRKDIAQD--MVLYHIKCDKNEIQAILPTREKLGKEVSE-CDEEELAAILKE QLP-DPEEYE---IYHFHFSDLEWT-EFDLVKCGIQMYYELGVVKKF-------------------------------QI PQE-VLVRFIFSVSKG--YRKITYHNWRHGFNVAQTMFTLL---MTGKLKQYYTDLEALAMVTAALCHDIDHRGTNNLYQ MK--SQHPLAKLHGSS--ILERHHLEFGKFLLS---EESLNIYQNLNRRQFEHVNNLMDIAIIATDLALYFKK---RTMF QKIVDESKTYDNEKEWAEYLSL----------------EATKK--------------------EIIMAMMMTACDLSGIA KPWEVQSK---VALLVAAEFWEQGDLEISVLQQQPIP--MMDRRKAAELPKLQ-VGFIDFVCTFVYKEFSRFHPQIQP-- ------------------------------------------------------------------MYERLLNNRKEWKA LADDYDANMKALEEKRKEEEAKTVNSKGAILTCN-------GESVP---------------------------------- -----------PSSTCCII------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Danio_rerio_PDE6B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MSVKKEDVEKFLDGNPDFTKTYFDKKLKPGAVASIMRV-PESKVDMDS--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------FKEIVSVEEGAIFYDLITDMQEN----VNMEKVIFKI LKRISALIHADRCSLFMYRQ--RNGIA-------------------------------ELATRLFNVNKDSELDDCVVA- ---------PDSEIVFPLDIGIVGHVAQTKKQVNVKDVTQ-DSHFS---------------------------TFVDELT EYTTHNLLAAPIMNGKD------VVAVIMAVNKTTGPH------FTDEDMDLFL-------------------------- -------------------------------------------------------------------------------- ----KYLKVGSLNLKIFH-LSYLHN------------CETRKG---QLLLWSAN----KVFE-----------ELTDIER QFHKALYT-VRAYLNCDRYSVGLLDMTKE-----KEFFDIWP-VLMGEQPPYSGPVTPDG-------------------R EIIFYKVIDYILHGKEDIK-VIP----------------NPTADHWALASGLPTYVAESGFICNIMNAASEEMFKFQT-E ALDD-----------------SGWTIKN---VLSLPIVNKKEE-----IVGVATFYNRKD------------GKPFDEHD EQLMEALTQFLGWSALNTDTYDKMNKLENRKDIAQD--MVLYHVKCRDDEIQDILKTREYFDREPRD-CEEEELLEILKK ELP-GPKKFE---IYAFHFSDFDCT-ELQLVMCGIQMYYEVGVVKKF-------------------------------QV PQEV-LVRFMYSVSKG--YRRITYHNWRHGFNVGQTMFTLL---TTGKLKQYYTDLEVMAMITAGFLHDIDHRGTNNLYQ VK--SQNPLAKLHGSS--ILERHHLEFGKFLLG---EESLNIFQNLNRRQTEHVFHLIDIAIIATDLALYFKK---RTMF QKIVDLSETYEERKKWIDFMSL----------------ETTRK--------------------EIVMAMMMTACDLSAIT KPWEVQSK---VALSVAAEFWEQGDLERTVLEQQPIP--MMDRNKAAELPKLQ-CGFIDFVCTFVYKEFSRFHPEIKP-- ------------------------------------------------------------------MFDGILNNRMHWKE RQEEYEAKLKAMEEAVKARQEAAAKNAANSNSTG-------GSGSK---------------------------------- --------------TCSIC------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Danio_rerio_PDE6A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MAAVDKDVAEKFLDSNPMFAKQYYDSRFRAKVVSDLLSTTKQTAVDISS--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------HHELSSMEECEIIFDMVRDMQEN----LHMERAVFNL MRHLSFMIRADRMSLFMYRQ--RNGIA-------------------------------ELATRIFNVHKDATLEECLVP- ---------PDSEIVYPLDTGIVGHVATAKKTVNVPDVTK-DSHFS---------------------------DFVDNLT EYETKNVLATPIMNGKD------MVAVMMAVNKIGAPH------FTAQDEETLK-------------------------- -------------------------------------------------------------------------------- ----KYLNFANLVLRVFH-LSYLHN------------CETRRG---QVLLWSAS----KVFE-----------ELTDIER QFHKALYT-VRAFLNCDRYSVGLLDMTKT-----KEFFDLWP-VLMGEVPPYSGPKTPDG-------------------R EVIFYKVIDYILHGKEDIK-VIP----------------NPPADHWALVSGLPTYVAENGLICNIMNAAQDEFFEFQK-E PLDE-----------------SGWMIKN---VLSLPIVNKKEE-----IVGVATFYNRKD------------GKPFDEMD ETLMESLTQFLGWSVLNTDTYDKMNKLENRKDIFQD--MVMYHVKCRKDEIQNILNTREMYDKEPDE-CEEDELEDILNE VLP-DSEESE---IFEFHFCDFEFS-ELDLVKCGIKMYYELGVVDKF-------------------------------HI PRE-TLVRFVYSVSKG--YRKITYHNWRHGFNVGQTMFTLL---MTGDLKRYYTDLEAMAMVTAGLCHDIDHRGTNNLYQ MK--SGNPLAKLHGSS--ILERHHLEFGKTLLR---DEALNIYQNLNRRQHETVIHLMDIAIIATDLALYFKK---RTMF QKIVDQSKTYDSWDSWTKYMML----------------ETTRK--------------------EIVMAMMMTACDLSAIA KPWEIQSK---VALSVAAEFWEQGDLERTVLEQQPIP--MMDRNKAEELPKLQ-CGFIDFVCSFVYKEFSRFHVEITP-- ------------------------------------------------------------------MLERLLNNRKEWNA LKEIHEAKVAKLDEAKKAKEEAHAN-SDHKQGNSVQPAAQS--------------------------------------- -------------KTCVIS------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Gasterosteus_aculeatus_PDE6A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MVDAAAAEQFLDANPQFAKQYYDANFRPKVVSDLLDGNRKAAMDISA--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------FHDLTAVEESEVLFDLMRDIQDN----LQMEKSVFNL MKHLSFMMRADRMSLFMYRQ--RNGVA-------------------------------ELATRLFNVNKDSQFDDCLVP- ---------PDSEIVYPLDMGIVGHVASTKKMVNIADVSE-SAHYS---------------------------EFVDELT EYKTKSVLAIPIMNGKD------MVAVMMALNKLDGPR------FTAKDEETLN-------------------------- -------------------------------------------------------------------------------- ----KYLNFGNLILRVFH-LSYLHN------------CETRKG---QVLLWSAS----KVFE-----------ELTDIER QFHKALYT-VRAFLNCDRYSVGLLDMTKT-----KEFFDLWP-VLMGEVPPYDGPKTPDG-------------------R EIIFYKLIDYILHGKEDIK-VIP----------------NPPADHWVLVSGLPTYVAETGLICNIMNAGQDDFFKFQK-I PLDD-----------------SGWTIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEMD ETLMESLTQFLGWSVLNTDTYDKMNKLENRKDIFQD--MVMYHVKCRKDEIQHVLNTRERWGKEPDE-CEEEALQEILSE VLP-DSKKCE---LFEFHFYDFHHT-ELELVKCGIKMYYELKVVDKF-------------------------------HI PRE-TLVRFIYSLSKG--YRRITYHNWRHGFNVGQTMFTLL---MTGDLKRYFTDLECMAMVTAGLCHDIDHRGTNNLYQ MK--SGNPLAKLHGSS--ILERHHLEFGKTLLR---DEALNIYQNLNRRQHDTVIHLMDIAIIATDLALYFKK---RTMF QKIVDQSKTYENWNEWTKYMML----------------ETTRK--------------------EIVMAMMMTACDLSAIA KPWEIQSK---VALSVAAEFWEQGDLERTVLEQVPIP--MMDRTKADELPKMQ-CGFIDFVCAFVYKEFSRFHVEITP-- ------------------------------------------------------------------MLDRLMNNRKEWNA LKEVHEAKMAAIEEAKKAKEEVA---AGARQGRYMFPNPPPGAAPR---------------------------------- ------------SSSCSTP------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Oryzias_latipes_PDE6B -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MGVGKEDVEKFLLENPAFAKTYFAKKLSPSSISKVSGL-PEKQIDFSQ--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------FQELSQIEESRLMYDVIKDMQEN----VNMEKVVFKI LKRISSLIHADRCSLFMYRQ--RNGIG-------------------------------ELATRLFNVSMDSVLEDCVVQ- ---------PDSEIVYPLDLGIVGNVALTKKNVNVKNVKE-SQHFS---------------------------SFVDELT DYETRNVLAAPILNGKD------MVAVIMALNKTTGPH------FTAEDEDLFL-------------------------- -------------------------------------------------------------------------------- ----KYLKIASLNLKIFH-LSYLHN------------CETRKG---QLLLWSAN----KVFE-----------ELTDIER QFHKALYT-VRAYLNCDRYSVGLLDMTKE-----KEFFDIWP-VLMGEQAPYAGPVTPDG-------------------R EVIFYKVIDYILHGKEDIK-VIP----------------NPTPDHWALQSGLPTYVAESGFICNIMNAGADETFKFQT-E ALDD-----------------SGWTIKN---VLSLPIVNKKEE-----IVGVATFYNRKD------------GKPFDDHD EQLMEALTQFLGWSALNTDTYDKMNKLENRKDIAQD--MVLYHVKCRNDEIQNVLNTREVYGCEPAE-CEEEDLLDILKK ELPPLIKKFE---IYEFRFSDFNCT-ELDLVKCGIQMYYEVGVVKKF-------------------------------QI PQEV-LVRFMYSVSKG--YRKITYHNWRHGFNVGQTMFTLL---TTGALKRYYTDLEVMAMITAGFLHDIDHRGTNNLYQ VK--SGNPLAKLHGSS--ILERHHLEFGKFLLS---DESLNIYQNLNRRQVDHVIHLTDIAIIATDLALYFKK---RTMF QKIVDLSKTYEEEKKWVDFMSL----------------ETTRK--------------------EIVMAMMMTACDLSAIT KPWEVQSK---VALSVAAEFWEQGDLERTVLEQQPIP--MMDRNKAAELPKLQ-CGFIDFVCTFVYKEFSRFHPQIQP-- ------------------------------------------------------------------MLDGILNNRKEWNA RKEEYEAKLKAIEEEMAAKEAAKAAKAA-QNNSS-------GGGSK---------------------------------- --------------TCSVC------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Homo_sapiens_PDE6A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGA-KEAAVDFSN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------YHSPSSMEESEIIFDLLRDFQEN----LQTEKCIFNV MKKLCFLLQADRMSLFMYRT--RNGIA-------------------------------ELATRLFNVHKDAVLEDCLVM- ---------PDQEIVFPLDMGIVGHVAHSKKIANVPNTEE-DEHFC---------------------------DFVDILT EYKTKNILASPIMNGKD------VVAIIMAVNKVDGSH------FTKRDEEILL-------------------------- -------------------------------------------------------------------------------- ----KYLNFANLIMKVYH-LSYLHN------------CETRRG---QILLWSGS----KVFE-----------ELTDIER QFHKALYT-VRAFLNCDRYSVGLLDMTKQ-----KEFFDVWP-VLMGEVPPYSGPRTPDG-------------------R EINFYKVIDYILHGKEDIK-VIP----------------NPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQK-E PLDE-----------------SGWMIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEMD ETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQD--IVKYHVKCDNEEIQKILKTREVYGKEPWE-CEEEELAEILQA ELP-DADKYE---INKFHFSDLPLT-ELELVKCGIQMYYELKVVDKF-------------------------------HI PQE-ALVRFMYSLSKG--YRKITYHNWRHGFNVGQTMFSLL---VTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQ MK--SQNPLAKLHGSS--ILERHHLEFGKTLLR---DESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKK---RTMF QKIVDQSKTYESEQEWTQYMML----------------EQTRK--------------------EIVMAMMMTACDLSAIT KPWEVQSQ---VALLVAAEFWEQGDLERTVLQQNPIP--MMDRNKADELPKLQ-VGFIDFVCTFVYKEFSRFHEEITP-- ------------------------------------------------------------------MLDGITNNRKEWKA LADEYDAKMKVQEEKKQKQQSAKSAAAGNQPGG--NP-SPGGATTS---------------------------------- -------------KSCCIQ------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Macaca_mulatta_PDE6A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKVISDLLGA-KEAAVDFSN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------YHSPSSVEESEIIFDLLRDFQEN----LQTEKCIFNV MKKLCFLLQADRMSLFMYRT--RNGIA-------------------------------ELATRLFNVHKDAVLEDCLVM- ---------PDQEIVFPLDMGVVGHVAHSKKIANVPNTEE-DEHFC---------------------------DFVDILT EYKTKNILASPIMNGKD------VVAIIMAVNKVDGSH------FTKRDEEILL-------------------------- -------------------------------------------------------------------------------- ----KYLNFANLIMKVYH-LSYLHN------------CETRRG---QILLWSGS----KVFE-----------ELTDIER QFHKALYT-VRAFLNCDRYSVGLLDMTKQ-----KEFFDVWP-VLMGEVPPYSGPRTPDG-------------------R EINFYKVIDYILHGKEDIK-VIP----------------NPPPDHWALVSGLPTYVAQNGLICNIMNAPAEDFFAFQK-E PLDE-----------------SGWMIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEMD ETLMESLAQFLGWSVLNPDTYESMNKLENRKDIFQD--IVKYHVKCDNEEIQKILKTREVYGKEPWE-CEEEELAEILQA ELP-DAEKYE---INKFHFSDLPLT-ELELVKCGIQMYYELKVVDKF-------------------------------HI PQE-ALVRFMYSLSKG--YRKITYHNWRHGFNVGQTMFSLL---VTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQ MK--SQNPLAKLHGSS--ILERHHLEFGKTLLR---DESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKK---RTMF QKIVDQSKTYESEQEWTQYMML----------------EQTRK--------------------EIVMAMMMTACDLSAIT KPWEVQSQ---VALLVAAEFWEQGDLERTVLQQNPIP--MMDRNKADELPKLQ-VGFIDFVCTFVYKEFSRFHKEITP-- ------------------------------------------------------------------MLDGITNNRKEWKA LADEYDAKMKVQEEEKQKQQSAKPAAAGNQLGG--NP-SPGGATTS---------------------------------- -------------KSCCIQ------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Mus_musculus_PDE6A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MGEVTAEEVEKFLDSNIGFAKQYYNFHYRGKVISDLLGA-KEAAVDFSN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------YHDVNSVEESEIIFDLLRDVQEN----LQAEKCTFNV MKKLCFLLRADRMSLFMYRT--RNGIA-------------------------------ELATRLFNVHKDAVLEDCLVM- ---------PDSEIVFPLDMGVVGHVAHSKKIANVPNTEE-DEHFC---------------------------DFVDNLT EYQTKNILASPIMNGKD------VVAIIMAVNKIDEPH------FTKRDEEILL-------------------------- -------------------------------------------------------------------------------- ----KYLNFVNLIMKVFH-LSYLHN------------CETRRG---QILLWSGS----KVFE-----------ELTDIER QFHKALYT-VRAFLNCDRYSVGLLDMTKQ-----KEFFDVWP-VLMGEAPAYSGPRTPDG-------------------R EINFYKVIDYILHGKEDIK-VIP----------------NPPADHWALVSGLPTYVAQNGLICNIMNAPAEDFFEFQK-E PLDE-----------------SGWMIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDDMD ETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQD--IVKYHVKCDNEEIQKILKTREVYGKEPWE-CEEEELAEILQG ELP-DAESYE---INKFHFSDLPLT-ELELVKCGIQMYYELRVVDKF-------------------------------HI PQE-ALVRFMYSLSKG--YRRITYHNWRHGFNVGQTMFSLL---VTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQ MK--SQNPLAKLHGSS--ILERHHLEFGKTLLR---DESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKK---RTMF QKIVDQSKTYESTQEWTQYMML----------------EQTRK--------------------EIVMAMMMTACDLSAIT KPWEVQSK---VALLVAAEFWEQGDLERTVLQQNPIP--MMDRNKADELPKLQ-VGFIDFVCTFVYKEFSRFHEEITP-- ------------------------------------------------------------------MLDGITNNRKEWKA LADEYEAKMKALEEEKQKQQAAKQAASGNQPGG--NP-TPGGAPAS---------------------------------- -------------KSCCIQ------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Felis_catus_PDE6A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MGEVTAEEVEKFLDSNVSFAKQYYNLRYRAKVISDMLGA-KEAAVDFSN--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------YHSLNSVEESEIIFDLLRDFQEN----LQTEKCIFNV MKKLCFLLQADRMSLFMYRV--RNGIG-------------------------------ELATRLFNVHKDAVLDECLVV- ---------PDSEIVFPLDMGVVGHVAHSKKLANVLNTEE-DEHFC---------------------------DFVDILT EYQTKNILASPIMNGKD------VVAVLMAVNKLNEPH------FTKRDEEILL-------------------------- -------------------------------------------------------------------------------- ----KYLNFANLIMKVYH-LSYLHN------------CETRRG---QILLWSGS----KVFE-----------ELTDIER QFHKALYT-VRAFLNCDRYSVGLLDMTKQ-----KEFFDVWP-VLMGEAPPYSGPRTPDG-------------------R EINFYKVIDYILHGKEDIK-VIP----------------NPPPDHWALVSGLPTYVAQNGLICNIMNAPAEDFFEFQK-E PLDE-----------------SGWMIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEMD ETLMESLAQFLGWSVLNPDTYESMNKLENRKDIFQD--MVKYHVRCDNEEIQTILKTREVYGKEPWE-CEEEELAEILQG ELP-DAEKYE---INKFHFSDLPLT-ELELVKCGIQMYYELKVVDKF-------------------------------HI PQE-ALVRFMYSLSKG--YRRITYHNWRHGFN-GQTMFSLL---VTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQ MK--SQNPLAKLHGSS--ILERHHLEFGKTLLR---DESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKK---RTMF QKIVDQSKTYETEQEWTQYMML----------------EQTRK--------------------EIVMAMMMTACDLSAIT KPWEVQSK---VALLVAAEFWEQGDLERTVLQQNPIP--MMDRNKADELPKLQ-VGFIDFVCTFVYKEFSRFHEEITP-- ------------------------------------------------------------------MLDGITNNRKEWKA LADEYDAKMKALEEEKQKQQAGVQAAAGNQPGG--NPGSAGGAPAS---------------------------------- -------------KSCCIQ------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Homo_sapiens_PDE6C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMS--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------FSELTQVEESALCLELLWTVQEE---GGTPEQGVHRA LQRLAHLLQADRCSMFLCRS--RNGIP-------------------------------EVASRLLDVTPTSKFEDNLVG- ---------PDKEVVFPLDIGIVGWAAHTKKTHNVPDVKK-NSHFS---------------------------DFMDKQT GYVTKNLLATPIVVGKE------VLAVIMAVNKVNASE------FSKQDEEVFS-------------------------- -------------------------------------------------------------------------------- ----KYLNFVSIILRLHH-TSYMYN------------IESRRS---QILMWSAN----KVFE-----------ELTDVER QFHKALYT-VRSYLNCERYSIGLLDMTKE-----KEFYDEWP-IKLGEVEPYKGPKTPDG-------------------R EVNFYKIIDYILHGKEEIK-VIP----------------TPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQK-G PVDE-----------------TGWVIKN---VLSLPIVNKKED-----IVGVATFYNRKD------------GKPFDEHD EYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQE--MLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKE DLP-DPRSAE---LYEFRFSDFPLT-EHGLIKCGIRLFFEINVVEKF-------------------------------KV PVE-VLTRWMYTVRKG--YRAVTYHNWRHGFNVGQTMFTLL---MTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQ MK--STSPLARLHGSS--ILERHHLEYSKTLLQ---DESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKK---RTMF QKIVDACEQMQTEEEAIKYVTV----------------DPTKK--------------------EIIMAMMMTACDLSAIT KPWEVQSQ---VALMVANEFWEQGDLERTVLQQQPIP--MMDRNKRDELPKLQ-VGFIDFVCTFVYKEFSRFHKEITP-- ------------------------------------------------------------------MLSGLQNNRVEWKS LADEYDAKMKVIEEEAKKQEGG--AEKAAED--------SGGG-DD---------------------------------- ----------KKSKTCLML------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------- >Macaca_mulatta_PDE6C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MGEINQDAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMS--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------FSELTQVEESALCLELLWTVQEE---GGTPEQGVHRA LQRLAHLLQADRCSMFLCRS--RNGIP-------------------------------EVASRLLDVTPTSNFDDNLVG- ---------PDKEVVFPLDIGIVGWAAHTKKTHNVPDVKK-NSHFS---------------------------DFMDKQT GYVTKNLLATPIVMGKE------VLAVIMAVNKVNASE------FSKQDEEVFS-------------------------- -------------------------------------------------------------------------------- ----KYLNFVSVILKLHH-TSYMYN------------IESRRS--