>Homo_sapiens_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNFAEKG-TKQPL-------------------LEDG --------------------------------------------------FDTIPLMTP------LDV-----NQLQFPP PDK--VVVK--------------------TKTEYEPDRKK----------------------------GKARPPQIAEFT VSIT---------------------------------------------------------------------EGVTERF KVSVLVL-----------------FALAF-------------------------LTCVV--------------------- ------------------FLVVYK---------------------------------------VYKYDRA---------- -------------------------------------------------------------------------------- ----CPDG----FVLK-------------------------NTQCIPEG----------------LESYYAEQDSS---- --------------------------------------------------------------------------AREKFY TVIN-----------------HYNL----------------------------------------AKQSI---------- -----------TRSVSPWMSVLSEEKLSEQ---E-------------------------------------TEAAEKSA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Pan_troglodytes_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNFAEKG-TKQPL-------------------LEDG --------------------------------------------------FDTIPLMTP------LDV-----NQLQFPP PDK--VVVK--------------------TKTEYEPDRKK----------------------------GKARPPQIAEFT VSIT---------------------------------------------------------------------EGVTERF KVSVLVL-----------------FALAF-------------------------LTCVV--------------------- ------------------FLVVYK---------------------------------------VYKYDRA---------- -------------------------------------------------------------------------------- ----CPDG----FVLK-------------------------NTQCIPEG----------------LESYYAEQDSS---- --------------------------------------------------------------------------AREKFY TVIN-----------------HYNL----------------------------------------AKQSI---------- -----------TRSVSPWMSVLSEEKLSEQ---E-------------------------------------TEAAEKSA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Macaca_mulatta_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNFAEKG-TKQPL-------------------LEDG --------------------------------------------------FDTIPLMTP------LDV-----NQLQFPP PDK--VVVK--------------------TKTEYEPDRKK----------------------------GKARPPQIAEFT VSIT---------------------------------------------------------------------EGVTERF KVSVLVL-----------------FALAF-------------------------LTCVV--------------------- ------------------FLVVYK---------------------------------------VYKYDRA---------- -------------------------------------------------------------------------------- ----CPDG----FVLK-------------------------NTQCIPEG----------------LESYYAEQDSS---- --------------------------------------------------------------------------AREKFY TVIN-----------------HYNL----------------------------------------AKQSI---------- -----------TRSVSPWMSVLSEEKLSEQ---E-------------------------------------TEAAEKSA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Mus_musculus_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNFAEKG-TKQPL-------------------LEDG --------------------------------------------------FDTIPLMTP------LDV-----NQLQFPP PDK--VVVK--------------------TKTEYEPDRKK----------------------------GKARPPKIAEFT VSIT---------------------------------------------------------------------EGVTERF KVSVLVL-----------------FALAF-------------------------LTCVV--------------------- ------------------FLVVYK---------------------------------------VYKYDRA---------- -------------------------------------------------------------------------------- ----CPDG----FVLK-------------------------NTQCIPEG----------------LESYYTEQDSS---- --------------------------------------------------------------------------AREKFY TVIN-----------------HYNV----------------------------------------AKQSI---------- -----------TRSVSPWMSVLSEEKLSEQ---E-------------------------------------TEAAEKSA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Rattus_norvegicus_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNFAEKG-TKQPL-------------------LEDG --------------------------------------------------FDTIPLMTP------LDV-----NQLQFPP PDK--VVVK--------------------TKTEYEPDRKK----------------------------GKARPPKIAEFT VSIT---------------------------------------------------------------------EGVTERF KVSVLVL-----------------FALAF-------------------------LTCVV--------------------- ------------------FLVVYK---------------------------------------VYKYDRA---------- -------------------------------------------------------------------------------- ----CPDG----FVLK-------------------------NTQCIPEG----------------LESYYTEQDSS---- --------------------------------------------------------------------------AREKFY TVIN-----------------HYNL----------------------------------------AKQSI---------- -----------TRSVSPWMSVLSEEKLSEQ---E-------------------------------------TEAAEKSA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Canis_familiaris_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MHLAAP------LMP-----LLLCFP- -DK--VVVK--------------------TKTEYEPDRKK----------------------------GKARPPKIAEFT VSIT---------------------------------------------------------------------EGVTERF KVSVLVL-----------------FALAF-------------------------LTCVV--------------------- ------------------FLVVYK---------------------------------------VYKYDRA---------- -------------------------------------------------------------------------------- ----CPDG----FVLK-------------------------NTQCIPEG----------------LESYYAEQDSS---- --------------------------------------------------------------------------AREKFY TVIN-----------------HYNL----------------------------------------AKQSI---------- -----------TRSVSPWMSVLSEEKLSEQ---E-------------------------------------TEAAEKSA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Bos_taurus_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNFAEKG-TKQPL-------------------LEDG --------------------------------------------------FDTIPLMTP------LDV-----NQLQFPP PDK--VVVK--------------------TKTEYEPDRKK----------------------------GKVRPPKIAEFT VSIT---------------------------------------------------------------------EGVTERF KVSVLVL-----------------FALAF-------------------------LTCVV--------------------- ------------------FLVVYK---------------------------------------VYKYDRA---------- -------------------------------------------------------------------------------- ----CPDG----FVLK-------------------------NTQCIPEG----------------LESYYAEQDSN---- --------------------------------------------------------------------------AREKFY TVIN-----------------HYNL----------------------------------------AKQSI---------- -----------TRSVSPWMSVLSEEKLSEQ---E-------------------------------------TEAAEKSA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Monodelphis_domestica_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------MTFFFSYG-SRQNF-------------------VGK- ------------------------------------------------------------------------------AR IHQ--VVVK--------------------TKTEYEPDRKK----------------------------GKFRTPKIAEFT ISIT---------------------------------------------------------------------EGVSERF KVTVLVL-----------------FALAF-------------------------LTCVV--------------------- ------------------FLVVYK---------------------------------------VYKYDHT---------- -------------------------------------------------------------------------------- ----CPEG----FVFK-------------------------NNQCIPAG----------------LENYYSEQDSN---- --------------------------------------------------------------------------ARGKFY TVIN-----------------HYNL----------------------------------------AKQTI---------- -----------TRSVSPWMSVLSEEKLSEQ---E-------------------------------------TEAAEKSA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Gallus_gallus_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNFSEKS-TKQPL-------------------LEDG --------------------------------------------------FDTIPLITP------LDV-----NQLQFPP PDK--VVVK--------------------TKTEYEPDRKK----------------------------GKFRTPKIAEFT ISIT---------------------------------------------------------------------EGVSERF KVTVLVL-----------------FALAF-------------------------LTCVV--------------------- ------------------FLVVYK---------------------------------------VYKYDHT---------- -------------------------------------------------------------------------------- ----CPEG----FVFK-------------------------NNQCIPAG----------------LENYYSEQDSN---- --------------------------------------------------------------------------ARGKFY TVIN-----------------HYNL----------------------------------------AKQTI---------- -----------TRSVSPWMTVLSEEKLSEQ---E-------------------------------------TEAAEKSA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Taeniopygia_guttata_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNFSEKS-TKQPL-------------------LEDG --------------------------------------------------FDTIPLITP------LDV-----NQLQFPP PDK--VVVK--------------------TKTEYEPDRKK----------------------------GKFRTPKIAEFT ISIT---------------------------------------------------------------------EGVSERF KVTVLVL-----------------FALAF-------------------------LTCVV--------------------- ------------------FLVVYK---------------------------------------VYKYDHT---------- -------------------------------------------------------------------------------- ----CPEG----FVFK-------------------------NNQCIPAG----------------LENYYSEQDSS---- --------------------------------------------------------------------------ARGKFY TVIN-----------------HYNL----------------------------------------AKQTI---------- -----------TRSVSPWMTVLSEEKLSEQ---E-------------------------------------TEAAEKSA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Anolis_carolinensis_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNLGEKS-SKQPL-------------------LEDG --------------------------------------------------FDTIPLITP------LDV-----NQLQFPP PEK--VVVK--------------------TKTEYEPDRKK----------------------------GKFRTPKIAEFT VSIT---------------------------------------------------------------------ESVSERF KVTVLVL-----------------FALAF-------------------------LTCIV--------------------- ------------------FLVVYK---------------------------------------VYKYDHT---------- -------------------------------------------------------------------------------- ----CPEG----FVFK-------------------------NNQCIPAG----------------LENYYSEQDSN---- --------------------------------------------------------------------------ARGKFY TVIN-----------------HYNL----------------------------------------AKQTI---------- -----------TRSVSPWMTVLSEEKLSEQ---E-------------------------------------TEAAEKSA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Xenopus_tropicalis_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --K--VVVK--------------------TKTEYERDHKK----------------------------GKFRAPKIAEFT ISIS---------------------------------------------------------------------EGVSERF KVTVLVL-----------------FALAF-------------------------LACVV--------------------- ------------------FLVVYK---------------------------------------VYKYDHA---------- -------------------------------------------------------------------------------- ----CPEG----FVLK-------------------------NNRCIPAA----------------LDNYYTEQDPS---- --------------------------------------------------------------------------AQGKFY TVIN-----------------HYNL----------------------------------------AKQTI---------- -----------TRSVSPWMTVLSEEKLSEQ---E-------------------------------------TEASQKSA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Takifugu_rubripes_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNFSDKN-SGKAV-------------------SEDG --------------------------------------------------FDTIPLITP------LDA-----SQLQFPP PEK--VVVK--------------------TKADYDAESKK----------------------------GKLRSPKIAEFS ISII---------------------------------------------------------------------EGVSERL KVTLLVM-----------------CALAF-------------------------LVCVV--------------------- ------------------FLVVYK---------------------------------------VYQYEQP---------- -------------------------------------------------------------------------------- ----CPDS----FVYT-------------------------QGRCMPVG----------------MDGSYLPQGPG---- --------------------------------------------------------------------------GRGRLF TLIN-----------------HYNI----------------------------------------AKQTI---------- -----------TRSVSPWMTIMSEEKVTEQ---E-------------------------------------TETAQKLA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Tetraodon_nigroviridis_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNFSEKN-SGKAV-------------------SEDG --------------------------------------------------FDTIPLITP------LDA-----SQLQFPP PEK--VVVK--------------------TKADYDAESKR----------------------------GKLRSPKIAEFS ISII---------------------------------------------------------------------EGVSERL KVTLLVM-----------------CALAF-------------------------LVCVV--------------------- ------------------FLVVYK---------------------------------------VYQYEQP---------- -------------------------------------------------------------------------------- ----CPDS----FVYT-------------------------QGRCMPVG----------------MDGGYLP-------- ------------------------------------------------------------------------------LF TLIN-----------------HYNI----------------------------------------AKQTI---------- -----------TRSVSPWMTIMSEEKVTEQ---E-------------------------------------TETAQKLA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Gasterosteus_aculeatus_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNFSDKN-TGKVV-------------------SEDG --------------------------------------------------FDTIPLITP------LDA-----SQLQFPP PDK--VVVK--------------------TKADY-IESKK----------------------------GKLRSPKIAEFS ISII---------------------------------------------------------------------EGVSERL KVTLLVI-----------------CALAF-------------------------LVCVV--------------------- ------------------FLVVYK---------------------------------------VYQYEQP---------- -------------------------------------------------------------------------------- ----CPDS----FVYT-------------------------QGRCMPAG----------------MYGMYPRQGPG---- --------------------------------------------------------------------------GRGRLF TLIN-----------------HYNI----------------------------------------AKQTI---------- -----------TRSVSPWMTIMSEEKITQQ---E-------------------------------------TETAQKLA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Oryzias_latipes_NSG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGNNFTEKN-NVKVV-------------------SEDG --------------------------------------------------FDTIPLITP------LDA-----SQLQFPP PDK--VVVK--------------------TKADYDAESKK----------------------------GKLRSPKIAEFS ISII---------------------------------------------------------------------EGVSERL KVTLLVI-----------------CALAF-------------------------LVCVV--------------------- ------------------FLVVYK---------------------------------------VYQYEQP---------- -------------------------------------------------------------------------------- ----CPDS----YVYM-------------------------QGRCMPAG----------------LYGSYPPQGPG---- --------------------------------------------------------------------------GRGRLF TLIN-----------------HYNI----------------------------------------AKQTI---------- -----------TRSVSPWMTIMSEEKVTQQ---E-------------------------------------TETAQKLA- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Homo_sapiens_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLNSNPSEKG-TKPPS-------------------VEDG --------------------------------------------------FQTVPLITP------LEV-----NHLQLPA PEK--VIVK--------------------TRTEYQPEQKNK---------------------------GKFRVPKIAEFT V------------------------------------------------------------------------------- --TILVS-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHS---------- -------------------------------------------------------------------------------- ----CPEG----FVYK-------------------------HKRCIPAS----------------LDAYYSSQDPN---- --------------------------------------------------------------------------SRSRFY TVIS-----------------HYSV----------------------------------------AKQST---------- -----------ARAIGPWLSA-AAVIHE-------------------------------------------PKPPKTQGH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Pan_troglodytes_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLNSNPSEKG-TKPPS-------------------VEDG --------------------------------------------------FQTVPLITP------LEV-----NHLQLPA PEK--VIVK--------------------TRTEYQPEQKNK---------------------------GKFRVPKIAEFT V------------------------------------------------------------------------------- --TILVS-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHS---------- -------------------------------------------------------------------------------- ----CPEG----FVYK-------------------------HKRCIPAS----------------LDAYYSSQDPN---- --------------------------------------------------------------------------SRSRFY TVIS-----------------HYSV----------------------------------------AKQST---------- -----------ARAIGPWLSA-AAVIHE-------------------------------------------PKPPKTQGH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Macaca_mulatta_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLNSNPSEKG-TKPPS-------------------VEDG --------------------------------------------------FQTVPLITP------LEV-----NHLQLPA PEK--VIVK--------------------TRTEYQPEQKNK---------------------------GKFRVPKIAEFT V------------------------------------------------------------------------------- --TILVS-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHS---------- -------------------------------------------------------------------------------- ----CPEG----FVYK-------------------------HKRCIPAS----------------LDAYYSSQDPS---- --------------------------------------------------------------------------SRSRFY TVIS-----------------HYSV----------------------------------------AKQST---------- -----------ARAIGPWLSA-AAVIHE-------------------------------------------PKPPKTQGH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Mus_musculus_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLNSNPGEKG-AKPPS-------------------VEDG --------------------------------------------------FQTVPLITP------LEV-----NHLQLAA PEK--VIVK--------------------TRTEYQPEQRNK---------------------------GKFRVPKIAEFT V------------------------------------------------------------------------------- --TILVS-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHS---------- -------------------------------------------------------------------------------- ----CPEG----FVYK-------------------------HKRCIPAS----------------LDAYYSSQDPS---- --------------------------------------------------------------------------SRSRFY TVIS-----------------HYSV----------------------------------------AKQST---------- -----------ARAIGPWLSA-AAVIHE-------------------------------------------PKPPKTQGH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Rattus_norvegicus_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLNGNPGEKG-AKPPS-------------------VEDG --------------------------------------------------FQTVPLITP------LEV-----NHLQLSA PEK--VIVK--------------------TRTEYQPEQRNK---------------------------GKFRVPKIAEFT V------------------------------------------------------------------------------- --TILVS-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHS---------- -------------------------------------------------------------------------------- ----CPEG----FVYK-------------------------HKRCIPAS----------------LDAYYSSQDPS---- --------------------------------------------------------------------------SRSRFY TVIS-----------------HYSV----------------------------------------AKQST---------- -----------ARAIGPWLSA-AAVIHE-------------------------------------------PKPPKTQGH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Canis_familiaris_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLNSNPSEKG-TKPPS-------------------VEDG --------------------------------------------------FQTVPLITP------LEV-----NHLQLPA PEK--VIVK--------------------TRTEYQPEQKNK---------------------------GKFRVPKIAEFT V------------------------------------------------------------------------------- --TILVS-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHS---------- -------------------------------------------------------------------------------- ----CPEG----FVYK-------------------------HKRCIPAS----------------LDAYYSSQDPN---- --------------------------------------------------------------------------SRSRFY TVIS-----------------HYSV----------------------------------------AKQST---------- -----------ARAIGPWLSA-AAVIHE-------------------------------------------PKPPKTQGH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Bos_taurus_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLNSNPSEKG-AKPPS-------------------VEDG --------------------------------------------------FQTVPLITP------LEV-----NHLQLPA PEK--VIVK--------------------TRTEYQPEQKNK---------------------------GKFRVPKIAEFT V------------------------------------------------------------------------------- --TILVS-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHS---------- -------------------------------------------------------------------------------- ----CPEG----FVYK-------------------------HKRCIPAS----------------LDAYYSSQDPS---- --------------------------------------------------------------------------SRSRFY TVIS-----------------HYSV----------------------------------------AKQST---------- -----------ARAIGPWLSA-AAVIHE-------------------------------------------PKPPKTQGH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Monodelphis_domestica_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGSNLSDKN-NKQPS-------------------GEDG --------------------------------------------------FQTVPLITP------LEV-----NHLQFPA PEK--VIVK--------------------TRTEYQPDQKNK---------------------------GKLRVPKIAEFT VSFT---------------------------------------------------------------------DGVTERL KVTILVS-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHS---------- -------------------------------------------------------------------------------- ----CPDG----FVYK-------------------------HKRCIPTS----------------LDAYYSAQDSS---- --------------------------------------------------------------------------SRGRFY TVIS-----------------HYSV----------------------------------------AKQTS---------- -----------SRAIAPWLSAAGPISHE-------------------------------------------AKAVKAEGH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Gallus_gallus_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGSNLNDKN-SKPPS-------------------SEDG --------------------------------------------------FQTVPLITP------LEV-----NHLQFPA PEK--VIVK--------------------TRTEYQPDQKNK---------------------------GKLRVPKIAEFT VSFT---------------------------------------------------------------------DGVTERL KVTILIS-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHS---------- -------------------------------------------------------------------------------- ----CPDG----FVYK-------------------------HKRCIPAS----------------LDAYYSAQDSN---- --------------------------------------------------------------------------SRGRFY TVIS-----------------HYSM----------------------------------------AKQTS---------- -----------SRAVSPWLSS-GSVNHE-------------------------------------------TKAAKTEGH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Taeniopygia_guttata_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGSNLNDKN-NKQPS-------------------NEDG --------------------------------------------------FQTVPLITP------LEV-----NHLQFPA PEK--VIVK--------------------TRTEYQPDQKNK---------------------------GKLRVPKIAEFT VSFT---------------------------------------------------------------------DGVTERL KVTILIS-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHS---------- -------------------------------------------------------------------------------- ----CPDG----FVYK-------------------------HKRCIPAS----------------LDAYYSAQDSN---- --------------------------------------------------------------------------SRGRFY TVIS-----------------HYSM----------------------------------------AKQTS---------- -----------SRAV-PWLPS-GSASHD-------------------------------------------NKAAKTEGH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Anolis_carolinensis_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGSNLNDKT-KQQPS-------------------NEDG --------------------------------------------------FQTVPLITP------LEV-----NHLQFPA PEK--VIVK--------------------TRTEYQPDQKNK---------------------------GKLRVPKIAEFT VSFT---------------------------------------------------------------------DGVTERL KVTILIS-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHS---------- -------------------------------------------------------------------------------- ----CPDG----FVYK-------------------------HKRCIPAS----------------LDAYYSAQDSN---- --------------------------------------------------------------------------SRGRFY TVIS-----------------HYSM----------------------------------------AKQTS---------- -----------SRSVSPWLSS-GSVNHE-------------------------------------------PKATKTEAH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Xenopus_tropicalis_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGSNLSDKN--KEPS-------------------GEDG --------------------------------------------------FQTVPLITP------LDV-----NHLQFPA PEK--VVVK--------------------TRTEYQSEQKNK---------------------------GKIRVPKIAEFT VSFT---------------------------------------------------------------------DGVTERL KVTILIS-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHS---------- -------------------------------------------------------------------------------- ----CPDG----FVYK-------------------------HKRCIPSS----------------LDAYYSAQDSN---- --------------------------------------------------------------------------SRGRFY TLIS-----------------HYSM----------------------------------------AKQTS---------- -----------SRSLSPWLSS-GSTNHE-------------------------------------------AKASKTEGH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Danio_rerio_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGSNLQDKG-AKAVS-------------------VEDG --------------------------------------------------FQNVPLITP------LDV-----TNLQYQA PDK--VVVK--------------------TRTEYQTEQKNK---------------------------AKLKVPKVEEFT ISVT---------------------------------------------------------------------DGVSERL KVTILIV-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHT---------- -------------------------------------------------------------------------------- ----CPDG----FVYK-------------------------HKRCIPAS----------------LEAYYTAQDGN---- --------------------------------------------------------------------------SRGRFY TVIS-----------------HYSM----------------------------------------AKQTT---------- -----------SRSLSPWLPAGSAQH-------D-------------------------------------VKPPNTDSQ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Takifugu_rubripes_NSG2a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGSNLQDKG-GKAGS-------------------VEDG --------------------------------------------------FQNVPLITP------LDV-----SSLQSHT PDK--VVVK--------------------TRTEYQTEKK------------------------------RLKVPKVEEFT ISFT---------------------------------------------------------------------DGVSERL KVTILII-----------------LALSF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHA---------- -------------------------------------------------------------------------------- ----CPNG----FIYK-------------------------HKRCIPAS----------------LEAYYAAQDAN---- --------------------------------------------------------------------------SRGRFY TVIS-----------------HYSM----------------------------------------AKQTT---------- -----------SHSISPWLPGGAGGQQH-----D-------------------------------------AKPPSGESH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Tetraodon_nigroviridis_NSG2a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGSNLQDKG-AKAVS-------------------VEDG --------------------------------------------------FQNVPLITP------LDV-----GSLQSHA PDK--VVVK--------------------TRTEYQTEKK------------------------------RLKVPKVEEFT -------------------------------------------------------------------------------- -VTILII-----------------LALAF-------------------------LSCIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHA---------- -------------------------------------------------------------------------------- ----CPDG----FIYK-------------------------HKRCIPAS----------------LEAYYAAQDAN---- --------------------------------------------------------------------------SRGRFY TVIS-----------------HYSM----------------------------------------AKQTT---------- -----------SHSVSPWLPGGAAGQQR-----D-------------------------------------AKPPSGESH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Gasterosteus_aculeatus_NSG2a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGSNLQDKG-GKPVS-------------------VEDG --------------------------------------------------FQNVPLITP------LDV-----GSLQSQA PDK--VVVK--------------------TRTEYQTEKK------------------------------RLKVPKVEEFT ISFT---------------------------------------------------------------------DGVSERL KVTILII-----------------LALAF-------------------------LACIV--------------------- ------------------FLVVYK---------------------------------------AFTYDHA---------- -------------------------------------------------------------------------------- ----CPDG----FIYK-------------------------HKRCIPAS----------------LEAYYAAQDAN---- --------------------------------------------------------------------------SRGRFY TVIS-----------------HYSM----------------------------------------AKQTT---------- -----------SHSVSPWLPGGAAGQQQQQQH-D-------------------------------------AKPPAGEGH -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Branchiostoma_floridae_NSG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MGKITTNPGEKKPAEPAV----------------------- -----------------------------------------------------EVQVEP-----------------TAPL PQK-------------------------VTATELPPPITVIN----------------------------APPPRRNRRC CIIT-------------------------------------------------------------------------LTV LIVLMVG-----------------ISITLG-------------------------------------------------- ------------------ALYMRK-------------------------------------HHGRDHDEPDHWEG----- -------------------------------------------------------------------------------- ----ENDGD-WDELMGGGG----------------------DKPGHPGS----------------HSGGHRPGHGSGEHR PG----------------------------------------------------------------HGSGGHRPGHGSGE HRPG-----------------HDSSS---------------------------------------SEEHGHGG------- -----------HRPHRPWPRPSGEPRPSGEPRPS-------------------------------------EKPRPRPSE VPYPPPH------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------- >Apis_mellifera_NSG2 -------------------------------------------------------------------------------- ---MTRRRRVPLVLRVCTGVLVLLFTTIAANTTEDPPTSSEKLSTEIIDRPSDATISVSNETIANKIASRNSGSTETENE AVDPSNNSTDQKDPETARESKDGEAEREEKVAIPTIHEDDQLARLPAADSSPNPGSSKLEDSIYGTSAGKSSSTKTLSED FYRLSRTNGLTTVTAKPALEEGKMDGTRNGVQMERSNVTTSWQESLASKIPKSSIVHRFDFPEGKGDKMKAEAKKERSEE SSLQKVRFLEKEEEQDEEKREESGEKKGSKNSEVAGLKGEVDPPISLINDTYVNYSHRYKTSTAEVSRENGSENGTNLIG EESTVVTHHPKEEVEVVGNVTQPAIQRIVEPRSRNATSKDANLGNVESGEIASNRNEDYSRRDPAKVNETSSVEIQRETS GNDGQKLVQ--------------------LTTTSPIATTTTITTTTTEKTFQEGSSTTSSPVPRGRTIAFAETNEFARST PSSRLDVSYTRRNESEDKGTKPYPYAKSSSKESSAPDSSNRLLIEITTEEGSAMEN----TIGKGRSEEKLIVTEASDVL ENSIQQRSKPAYRDEGSGSNESSTASSHVARPSPTPTDSSTSVPRGSSTERGMIQGSSREESSTSVGNDVPRWNDSQETV SSSVDVTGNGITEVRPRPEESRPRDELPFRQITEPSFRSS-------------DLPSIQRSNSSMEPLVPAN-----TER SASSSSPVATTIEQ----TFVANATESSPQSATSDANATNEIPSSDPDQSFAPTTTGVEYEFVSLSFDSTEYPPPRNVTT EEASTG---------------------EDAAADRTSSTVPDLLSPTKNDSNEAPTTLMPPSDESDDSSSMNETTDRATIT TTVFVPPN----WVTRGSRDEAAAATTR-TSLLEEGIGWSGVDEVARTTDG------------FPLDSWSTVEDGKEEEE GIATISS-------------------------------------------------------------DSKDTTEQPAQF TPMSSVNATDGTVAPSA-TPSEHSISSTVSSPTIGSR-------------------------DVPSRKSDNALP------ -----------TRQEITWLVRIVMEGGRYDVCPKMDKLKAILANILQSGINKSVSDEQIILHENPCQESSDSTPSSSSST DMTSILVYVVDEKGKFDMNMTKILPSLYEESRDRITFPIKETIPDSGNAVAAIVVSSVALICLVLLAGLLFIMRKRQTRF NYGERCRPVSLDAYSLDSVSAYNSVRRKGVARSSKRSYGNPTFEDSSAIPSHPLNFAGLSSFCNDINAINEEFAGIPQVS AKIDELPGGAEVKNRYANVIPLPETRVLLQKVNNDPLTEYINASYVRGPKNATKYYIACQAPMESTVTDFWRMIWEQQSK VIIMLTDLVENGVEKCTEYIPPSEVTDCRRLYGDFQVTLKKRETKEKYAISTLHLNNLEKNTFREVYHIWYLWPVNGVQS DGAGLIAVLLEARALQRGGPGPIVVHCSPGTGRTGTLIALDLGIRQYEITRTVDVPRVVYTIRRDRAGAVKTKEQYAFIY KALNLYATKLAGGVLEST-------------------------------------------------------------- ------------------------------------------------------------- >Homo_sapiens_CALY -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------MVKLGCSFSGKPGKDPGDQ------------------DGAA --------------------------------------------------MDSVPLISP------LDI-----SQLQPPL PDQVVIK----------------------TQTEYQLSSPDQ---------------------------QN-FPDLEGQRL NCSH---------------------------------------------------------------------PEEGRRL PTARMIA-----------------FAMAL-------------------------LGCV---------------------- -------------------LIMYK---------------------------------------AIWYDQFT--------- -----------------------------------