>Homo sapiens _CALCOCO1 ------------------------------MEESPLSRAPSRGGVNFL-------NVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPES-TTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFREPRP-MDELVTLEEAD----GGSDILLVVPKATVLQN----------------QLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHG---------------------EITEERDILSRQQGDHVAR-------ILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQ-----------AQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLK----------------------------------------------------------------------------------------------------EEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQ--------------------------------EERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWN---------EDATTEDEEAAVGLS-----CPAALTDSEDESPE-----------------------DMRLP----PYGLCER-------------------------------------------------------------------------------------------------------------------------------------GDPGSS-PAGPR---------------------------EASP-----LVVISQPA--PISPH-----------LSGPAEDS--------------------------------SSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE >Mus musculus_CALCOCO1 ------------------------------MEESSLSRAPSRGGVNFL-------NVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPES-TTDGSPTHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRP-MDELVTLEEAD----GGSDILLVVPKATVLQN----------------QLDESQQERNDLMQLKLQLEDQVTELRSRVQELEAALATARQEHSELTEQYKGLSRSHG---------------------ELSEERDILSQQQGDHVAR-------ILELEDDIQTMSDKVLMKEVELDRVRDTVKALTREQEKLLRQLKEFQADKEQSEAELQTVREENCCLNTELEEAKSRQEEQGAQVQRLKDKLAHMKDTLGQ-----------AQQKVAELEPLKEQLRGVQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAEVNGRLAELSLHMK----------------------------------------------------------------------------------------------------EEKCQWSKERTGLLQSMEAEKDKILKLSAEILRLEKTVQ--------------------------------EERTQSHVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQTEKQELLEYMRKLEARLEKVADEKWT---------EDAATEDEEATAGLS-----CPASLTDSEDESPE-----------------------DMRLP----SYGLCES-------------------------------------------------------------------------------------------------------------------------------------GNTSSS-PPGPR---------------------------EPSS-----LVVINQPA--PIAPQ-----------FSGPGEAS--------------------------------SSDSEAEDEKSVLMAAVQSGGEEASLLLPELGSAFYDVASAFTVSSLSEASPGVPANPPWKECPICKERFPAESDKDALEGHMDGHFFFSTQDPFTFE >Rattus norvegicus_CALCOCO1 ------------------------------MEESSLSRAPSRGGVSFL-------NVARTYVPNTKVECHYTLPPGTTPSASDWIGIFKVEAACVRDYHTFVWSSVPET-TTDGSPTHASVQFQASYLPKPGAQLYQFRYVDRQGRVCGQSPPFQFREPRP-MDELVTLEEAD----GGSDILLVVPKATVLQN----------------QLDESQQERNDLMQLKLQLEDQVTELRSRVQELEAALATARQEHSELTEQYKGLSRSHG---------------------ELSEERDILSQQQGEHVAR-------ILELEDDIQTMSDKVLMKEVELDRVRDMVKALTREQEKLLGQLKEFQADKEQSEAELQTVREENCHLNTELQEAKGRQEEQGAQVQRLKDKVAHMKDTLGQ-----------TQQKVAELEPLKEQLRGVQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAEVNGRLAELSLHMK----------------------------------------------------------------------------------------------------EEKCQWSKERTGLLQSMEAEKDKILKLSAEILRLEKTVQ--------------------------------EERSQSHMFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQTEKQELLEYMRKLEARLEKVADEKWN---------EDAATEDEEATAGLS-----CPAALTDSEDESPE-----------------------DMRLP----SYGLCER-------------------------------------------------------------------------------------------------------------------------------------GNTSSS-PPGPR---------------------------ESSS-----LVVINQPA--PIAPQ-----------LSGPGEAS--------------------------------SSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSTFYDVASGFAVSSLSEASTGVPAIPAWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE >Bos taurus_CALCOCO1 ------------------------------MEESSLSRAPSRGGVNFL-------NVARTYIPNTKVECHYTLPPGTVPSASDWIGIFKVEAACVRDYHTFVWSLVPES-VTDGSPIHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRP-MDELVTLEETD----GGSDILLVVPKATVLQN----------------QLDESQQERNDLMQLKLQLEGQVTELKSQVQELEKALAAARQEHAELAEQYKGLSRSHG---------------------ELTEERDILSRQQGDHVAR-------ILELEEDIQTISEKVLMKEVELDRVRDSVKALTREQEKLLGQLKEVQADKEQSEAELQMAQQENRRLNLELQEAKDRQEEQSAQAQRLKDKVAQMKDTLGQ-----------VQQRVAELEPLKEQLRGAQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAGVNGRLAELSLHLK----------------------------------------------------------------------------------------------------EEKSQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQ--------------------------------EEKTQSQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWS---------EDPATEDEEAAVGLS-----CPAALTDSEDESPE-----------------------DMRLP----PYSLCES-------------------------------------------------------------------------------------------------------------------------------------GDSGSSPATGPR---------------------------EASP-----LVVISQPA--PIAPQ-----------LSGPAEDS--------------------------------SSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFAVGPLTEASTGGPATPPWKECPICKERFPVHTQT---------HTYTHTHTHA--- >Canis familiaris _CALCOCO1 ------------------------------MEESSLSRAPSRGGVNFL-------NVARTYIPNTKVECHYTLPPGTVPSASDWIGIFKVEAACVRDYHTFVWSSVPES-AADRSPVHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRP-MDELVTLEETD----GGSDILLVVPKATVLQN----------------QLDESQQERNDLMQLKLQLEGQVTELRNQVQDLEMALATARQEHAELREQYKGLSRSHG---------------------ELIEERDILSRQQGDHVAR-------ILELEDDIQTISEKVLTKEVELDRVRDTVKALTREQEKLLGQLKEVQADKEQSEAELQMAQQENHRLNLELQEAKGRQEEQGAQAQRLKDKVAQMKDTLGQ-----------AQQRVAELEPLKEQLRGAQELAASSQQKAALLGEELASAAGARDRTMAELHRSRLEVAGVSGRLAELSLHLK----------------------------------------------------------------------------------------------------EEKSQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQ--------------------------------EEKTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWS---------EGTATEDEEAAAGLS-----CPEALTDSEDESPE-----------------------DMRPP----SYGLCER-------------------------------------------------------------------------------------------------------------------------------------GDSGS--PAGPR---------------------------EASG-----RVVVSQPA--PVAPQ-----------LSGAAEDT--------------------------------SSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFAVGPLSEASTGGPATPPWRECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE >Equus caballus_CALCOCO1 ------------------------------MEESSLSRAPSRGGVNFL-------NVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPES-ATDGAPVHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRP-MDELVTLEETD----GGSDILLVVPKATVLQN----------------QLDESQQERNDLMQLKLQLEGQVTELRSRVQELETALATARQGHADLTEQYKGLSRSHG---------------------ELTEERDILSRQQGDHVAR-------ILELEDDIQTISEKVLTKEVELDRVRDTVKALTREQEKLLGQLKEVQADKEQSEAELQMAQQENHRLNLELQEAKGRQEEQSAQAQRLKDKVAQMKETLGQ-----------AQQRVTELEPLKEQLRGAQELAASSQQKAALLGEELASAAGARDRTMAELHRSRLEVAGVNGRLAELTLHLK----------------------------------------------------------------------------------------------------EEKSQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQ--------------------------------EERTQNQVYKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWN---------EDAATEDEEGAAGLS-----CPAPLTDSEDESPE-----------------------DMRLP----PYGLCEH-------------------------------------------------------------------------------------------------------------------------------------GDPGSS-PAGPR---------------------------EASP-----LVVISQPA--PIAPH-----------LSGPAEDS--------------------------------SSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFAVGPLSEASTGGPATPPWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE >Anolis carolinensis_CALCOCO1 -------------------------------------------GVTFL-------NVAPSYVPHTKVECHYNLPPGMKPSARDWIGIFKAEASSVRDYYTFVWCTVPDGGTPAGALLHCSVQFQASYLPKPGPQQYQFRYVDRRGEVRGQSSSFQFNEPRP-MDELVTLEEASDDG-AGTDMLLVVPKATLLET----------------QLEESRQQQGVLLQESCRLKDEVKELRSHMAELEAALGSLRDDHTKLAAQYKARKTEWV---------------------EVSKQKDTLSLQEAEHLAR-------IRELEGDIQAMGEKMLLRETELDRVKDTVKSLLREQEQIHNQLKEEYAEKEQYQVKLQASVEESRSLASDLQEAKNLHGEKISQTLVLQEDVNKLQQKLAT-----------ANRRTAQMEALCEQLRSTQDVLAASQQKVALLGEELASVASIRDRTISDLHKSRLEAAETNIKLADMTLKWK----------------------------------------------------------------------------------------------------EGKGQWWKEKTTLLQNMEAEKDKILKLSAEVLRLEKSLQ--------------------------------EERSQRQVLRVELAQERDSSLVQVSESRRELRELRAALQVAQKEKEQLQAEKQELLIYIRRLEERLEKVADDKWS---------ESVLVDKEETALEAPD---ALDSPLSDSEDECPE-----------------------DMRLPAQIGSYSLCDN-------------------------------------------------------------------------------------------------------------------------------------RAATTT-PPCAR---------------------------GPAR-----TVVISQPA--PIASQ-----------IKQPPEDS--------------------------------SSDSEAEDEKAVLMAAAQSGGEETNLLLPELGSGFYEVASGLTGRQLSE-----PGTSFWKECPICHERFPPESDKETMDTHVDAHFFFSTHDPFTFE >Danio rerio_CALCOCO1 --------------------------------------MEKTWRVEFR-------NVGSCYFPQSRVDCHYTINPQHTWASNDWIGLFKVGWSSVKEYHTFVWAVAPSS-YKEGTSVNCCVNFQASYLPGPSAQQYQFVYVDGKGEICSCSAAFTFSAPKP-LEELVTLEEEGQGEEVGEDMLLVIPRAQLLQS----------------RLQECLKERAELLQALEAAD---QNVEREKGRRERDRGSWEHTRKELERKIDDLKEEVREYREKVEDMKKKQKEVEDLGEALTEEKRALLAQKEANEQR-------IRELEEDIKILTQRGLERETDLERMRERAKKSAAQK-------REDEDEHKNLKLKMEQTEKELHSLSAEFQSLRSSLAQRDTHALQLRDTITTLTHKLNS-----------AHRKEAANELALNELRSVQERLNVSEHCVETLRGELRDMVAQRDSAHAELHQARLQAAQLTLQLADASLALR----------------------------------------------------------------------------------------------------EGRANWAQERETLQQNAEIDKVRLERQNDEIQQKEEMLQ--------------------------------KARMEREKAVVELGREKDCN-----------RELKASLRVAQKEKEQLQTEIQEVMEYSRQLERRLEVLSDCKWS---------ETALLQSSR----------AESPLLSDSEDENPEAL--------------------QDTHSSGPLNHYSLCEQ-------------------------------------------------------------------------------------------------------------------------------------PQSDLLLPATPP---------------------------PSPR--HPSTVVISQPA--PLSSP-----------HQPSARSH--------------------------------THSSESEEEYEAALSGGHSSGEETALLLPDNRDTTLGELAESPLW----------------------------------------------------- >Takifugu rubripes _CALCOCO1 ------------------------------ASSTTPGTMEK--CVEFR-------NVGCSYFPQSRVDCHYTISSQHTWASNDWVGLFKMGWTSVRDYHTFVWALVPPS-YEEGTEVNCCVQFQAAYLPKASCHEYEFVYISAKGEVCSRSSSFIFCAPKP-LEDLVTLEEDSHGEEGGTDMLLVVPRAELLQN----------------RLQECLQERAELLQAHEATN---RQREKDKLEYKRAREAWDRRRSEVESDISRLQRELKHSHEQEE---------QDLVELLTQEKSTLLEANEESRVR-------IRELEEDIKTLTQRTVDRETEMERMKERAKRAGAQR-------KEEESERSALQSKLEQTEADLRSLSKEFQGLRTSLAQRDTSVLQLQSTITTLTQKLTA-----------AHRKEAEHEATLKEMRSLQERLNTSERASEGLKSDLSSMVAQRDRTQSELHQARLQAAQLTLQLADASLALR----------------------------------------------------------------------------------------------------EGRARWAQERQGLQLTAEKDHARLQKLTAEMETIEESLQ--------------------------------EERMERVKLEVEIGREKDCNRVQLCETRRELQELKTSVRVTQKEKEQLLAEKQELMHYICQLEQKTGTVSSAKWS---------AAPVLFPGPCFCAAGR----PASATSDSEDENPEAL--------------------QPLRPPRPLGNYSLCEQ-------------------------------------------------------------------------------------------------------------------------------------GELELLRLATPP---------------------------PSPREAERSAVVINQPA--PLTSP-----------HQASAETA--------------------------------AHSSDSEEESDPLQCGRLGSGDETALLLPE-------------------------------------------------------------------- >Oryzias latipes _CALCOCO1 ------------------------SLKIEERYSRSRTREGKKHDSPVRGVIIFLLNVGCSYFPQSRVDCHFTLSAQHKWASSDWVGLFKVGWSSVKDYHTFVWALVPVD-YQEGADVNCCVHFQASYLPKPSSQEYEFVYVDAQGEVCSRSPKFTFCAPKP-LEDLVTLEEESYGEEEGTDMLLVVPRAELLQS----------------RLQECLQERAELLQLQERLQEDLRQSRETIVEMERRLEVVYGAEANNEE--------------------------QLLGQSLTQEKASLMEARESSEMR-------IQDLEENIKTLTQRAVEREAELERIKERTKRANALK-------NEEESERTSLQVKFEQTEAELRSLSKEFQGLRNSLAQRDTSVLQLQNTITTLTQKLTI-----------AQRKETENEASLKEMRSLRERLHMSERAAEGLKSDLSAMIAQRDHGQAELHQARLQAAQLTLQLADSSLALR----------------------------------------------------------------------------------------------------EGKAQWAQERQKLQLAAEISHDRLEKLNSDMLRVEERLQ--------------------------------EEKMERVKLEVELGREKDCNRVQLSETRRELQELKGSLRVSHKEKEQLLAEKQDLMDYICQLEQKIGMAASTSWE---------AAPLASSGS-----------PASVPSESEDESPEPL--------------------EIHHPPQNVGHYSLCEH-------------------------------------------------------------------------------------------------------------------------------------GQPDSLHLATPP---------------------------QSPKEANWRLVVISQPA--PLSLP-----------H----------------------------------------------------------------------------------------------------------------------------------------- >Gasterosteus aculeatus_CALCOCO1 --------------------------------------MEKPWRVEFR-------NVGSSYFPQSRVDCHYTLNTHHNWASNDWIGLFKVGWSSVKEYHTFVWALVPTD-YQEGTDVNCCVHFQASYLPKPSSQDYEFAYIDAKGEVVCCSSAFTFCAPKP-LEDLVTLEEEPHGEEGSTGMLLVVPRAELLQG----------------RLQECLRERAELLQAQEVAN---RRREKDQEEHKRAREAWDRRHRALERDVARLQEELKQSREKVEGME----EVQAFGESLAQEKSALLDASEASKVR-------IKELEEDIKTLAQRSVEKETELERMKERAKRAGAQR-------KEEEGDRKSLQSKLEQTEGELRSLSKEFQVLRNSLAQRDTSVLQLQNSITTLTQKLTA-----------AHRKEAQNEATLKEMRSLRERLNLSERAAEALKSDLSAMVAQRDHGQAEMHQARLQAAQLTLQLADSSLAMR----------------------------------------------------------------------------------------------------EGRARWAQERQNLQRTAEKDHERLEKLSTEMQRTEERLQ--------------------------------EERMERVKLEVELGRERDCNRVQLSETCRELQELKASLRVAQKEKEQQLAEKQELMEYICQLEQKMGTAVGAKWS---------AAPIAYTGDRFFSSVHPADLPASVLSDSEDENPEAL--------------------QPLRPPRPLGHYSLCEQ-------------------------------------------------------------------------------------------------------------------------------------GQPDSLLLATPP---------------------------PSPREVERSTVVINQPA--PLSSP-----------RQADADRQ--------------------------------AHSSDSEEESDTLKCGRHGSGEETALLLPE-------------------------------------------------------------------- >Tetraodon nigroviridis _CALCOCO1 ---------------------------AEEAAIPTLGTMEE--RVQFR-------NVGCSYFPQSRVDCHYTIASQHTWASSDWVGLFKVGWSSVKDYHTFVWALVPPN-YEEGTEVNCCVQFQASYLPSPSCHEYEFVYVSAKGEVCSRSSKFTFCAPKP-LEDLVTLEES-HGEEEGTDMLLVVPRAELLQVSRTQNRLVKAVMGLKIRLQECLQERAELLQAHEAAN---RQREKEKMEYRGAREAWDRRHRELES----------------------------------EEKSTLLEANEESRVR-------IRELEEDVRTLTQRTVDRETEMERMKERAKRAGAQR-------KEEESERSALQSKLEQTEAELRSLSKEFQGLRNSLAQRDTSVLQLQSTITTLTQKLTA-----------AHRKEAEHEATLKEMRSLRERLNTSERTSEGLKSNLSSMVTQRDRTQSELHQARLQAAQLTLQLADASLALR----------------------------------------------------------------------------------------------------EGRARWAQERQSLQLSAEKDHERLQTLNAEIQKMEETLQ--------------------------------EERMEKVKLEVEIGREKDCNRVQLCETRRELQELKASLRVTQKEKEQLLAEKQELMQYICQLEQKTGMVSSAKWS---------TAPLLFPG--LCAAGR----PSSATSDSEDENPEAL--------------------QPLRPPRPLGNYTLGEQ-------------------------------------------------------------------------------------------------------------------------------------GGPGSLDLTTPP---------------------------PSPREAERSTVVINQPA--PLSSP-----------RQASADTA--------------------------------AHSSDSEEESDPLQCGRLGSGDETALLLPDHSDSGHRYNR---------------------------------------------------------- >Homo sapiens_CALCOCO2 ----------------MEETIKDPPTSAVLLD------HCHFSQVIFN-------SVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPID-LNNKSAKQQEVQFKAYYLPKDD-EYYQFCYVDEDGVVRGASIPFQFRP-ENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSC--------------ISLQKQNSDMQAELQKKQEE---LETLQSINKKLELKV----------KEQKDYWETELL---------------------QLKEQNQKMSSENEKMGIR-------VDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKE-NDHLFLSLTEQRK-------------DQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSE----------NEIICNALQRQKE----RLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGARQNPGLAYGN----------------------------------------------------------------------------------------------------------PYSGI---QESSSPSPLSIKKCPICK---ADDICDHTLE--------------------------------QQQMQPLCFNCPICDKIFPATEKQIFEDHVFCHSL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Mus musculus _CALCOCO2 ------------------MDQCPIPTLLE---------HGNFSQVLFN-------NVEKFYAPRGDIMCYYTLTEKFIPRRKDWIGIFKVGWKTTQEYYTFMWAPLPKD-QNKDSATQQEIQFKAYYLPKDV-ERYQFCYVDEDGLVRGTSVPFQFCP-DPDEDIMVVINKEKVEEMEQLSEELYQQNQELKDKY--------------ADLHEQLQRKQVALEATQRVNKTLEHKVEEKASWEKEKASWEEEKASWEEEKASWEEEKA---------------------SWEE--EKASWEEEKASW------------------------------EEEKASWE-EEKASWEEEKASWEEEK----------------ASWEEE-------------------------KASWEK----------EKASWEEEKASWEKEKAPWEVE-KAPWKEVKAYWWN-----DLHR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Rattus norvegicus _CALCOCO2 MTSPPEFGGVAVSNERTNKNRSRLPTSIEESDSTMEERHSNFSQVLFN-------NVEKFYIP-GDVVCCYTLTEKFVPRPKDWVGVFKVGWETTQEYYTFMWAPMPDD-LNTESATQQKIQFKAYYLPKDE-EHYQFCYVDEDGLVQGISIPFQFPPPDSEEDIMIVINKEKMDEMEQLREELYQENQELKDKY--------------ADLHEQLQRKQVALEATQRMNESLGQEVEQKASWEKQKASWEEQKASWEEQKASWESEML---------------------HLKEYNQKITSEKENMEIR-------IEDLLIQLMYKYRGLVDFILKDEEKTKHWERLQKESNSQLSSSFTEQARVVALQQKLININIDYNHLQQDNDILCGENRRLNTEICLLKNENKALRSSLAN----------KDVSSNERAAEPEVPTPQVDAEPEAPTPQVDAEPEDPSAQADVEPEVPSAQADAEPEVPSAQADAEPEVPSAQADAE--------------------------------------------------------------------------------------------PEVPSPQADAEPEVPSPQADAEPEVPSAQADAETEVPSQADAE-------------------------------PEVPSPQADAEPEVPSAQADAEPEVPSPHVDAEPEVPSPHIDAEPEAPSAQADAEPEAPSAQADAEPEVPSPHVDAEP----EVPSAQADAEPEVPSAQADAEPEAPSAQADVEPEAPSAQADAEPEAPSAQVAEPEVPSAQADAEPEVPSAQADAEPEAPSAQVAEPEVPSAQADAEPEVPSPQADAEPEVPSPQADAEPEVPPAQVDAEPEVPSPQADAEP--------------------------------------------------------------------EVSSPQAAAEPE--------------------------VSSPQVDAEPEVSSPQAAAEPEV-----------PSPQADAEPEVPSPQADAEPEVPSPQVDAESEAPSPQAAPESEVPSPQAAPESEVPSAQRAGSSNPLLWECDEDSYTGPKLGAAGAQRFVLSILYEDLQSNKEMGLLGQLSHTHPCLSTPACASLLGHILCGIWFLL--- >Bos taurus_CALCOCO2 ----------------MEETVDDPPTSAVLLD------HCHFSQVIFN-------SVEKFYIPGGDITCYYTLTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPVD-LNSESAKQQEVQFKAYYLPKDD-EYYQFCYVDQDGVVRGASIPFQFRP-ENEEDILVVTTQSEVEEIEQHNKELCKENRELKDSC--------------VSLQKQNSDMQATLQKKQEE---LETLKSINKKLEQTM----------KEQKDCWEIELL---------------------QLKEQNQKMSSENEKMGVR-------VDQLQAQLSNQGREMEKLVQGVQDKTEQLEHLKEE-NGQLFLSLTEQRE-------------HQKKLEQTVEEMKQKETTAAKKQQELTDQNMDLSKRLSE----------NMIIHDVLQREKE----KMEKENDYLKRENNRLLSYMGLDCDSLSYQVPTSNQGGTRQDPGLVFGN----------------------------------------------------------------------------------------------------------PYSGI---QESSAPSLLSIKKCPTCKSDFAADVFDHNLAL-------------------------------EQHLQTLSLNCPICDKTFPAKEKQIFEDHVFCHTL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Canis familiaris_CALCOCO2 ----------------MDETVEDPPTSAVLLD------HCHFSQVIFN-------SVEKFYVPGGDVTCYYTLTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPVD-LNSNSAKQQEVQFKAYYLPKDD-EYYQFCYVDQDGVVRGASIPFQFRP-ENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSC--------------VSLQKQNSDMQAELHKKEED---LETLKSTNKKLEQQV----------KAQKDCWETELL---------------------QLKEQNQKMATENEKLGVR-------VEQLQAQLSTQEKEIEKLVQGSQDKTEQLEHLKKE-KSQLLLTLTQQRE-------------HQKKLEQTVEEMKQEETTAMKKQQELTDENSGLSKTLSE----------NKIMCSTLQREKE----RLEKENDLLKRENSRLLSYMGLDFDSLPYQAPTSDQAGAGQNPGLVYGN----------------------------------------------------------------------------------------------------------PYSGI---QESSAPSLRTMKRCPTCKSDLADDIFGPTLE--------------------------------QQHMEALCLNCPICDKTFPAREKQIFEDHVFCHTL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Equus caballus_CALCOCO2 ----------------MEEITEDPPTSAILLD------HCHFSQVIFN-------SVEKFYVPGGDVTCYYTLTQHFLPRRKDWIGIFRVGWKTTREYYTFMWVTLPVD-VNSDSAKQQEVQFKAYYLPKDD-EYYQFCYVDQDGVVRGASIPFQFRP-ENEEDILVVTTQGEVEEIEQHNKELCKENQKLKDSC--------------VSLEKQNSDMQAELQKNQEE---LETLKSINKKLEEKV----------KEQKDHWETELL---------------------QLKEQNQKMASENEKMGVR-------VDQLQAQLSTQEKEMEKLVQGDQDKTEQLEHLKKE-NGQLFLSLTEQKE-------------HQKKLQQTVEEMKQKETTAMKKQQELMDQNFDLSKRLSE----------NKIIYDVLQREKE----NMERENDLLKRENSRLLSYMGLDFDSLPYQAPTSDQGGAGQNPRLVYGN----------------------------------------------------------------------------------------------------------PYSGI---QESSAPGQLSIKKCPTCNSDLADDIFDPTLE--------------------------------QQHMQSLCLNCPICDKVFPAKEKQIFEDHVFCHTL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Gallus gallus_CALCOCO2 ----------------MDETSDEPPTSAVILD------SSHFSHVIFN-------DVEKFYVPGGDVTCRYTLTHNIVPRGKDWVGIFRVGWKTTREYYTFMWAPRPSD-VHGDSAVQQEIQFKAYYLPKDD-EYYQFCYIDQDGTIRGASVPFQFRA-ETEDDILVVTTQGEVEEIELQNKNLLKENKKLQANC--------------ESLQKQNTDLQEDLKKTQELQNVLESLRSSTEKLELELSSLKKENKHLKELNECREAELH---------------------QFKEQIQNVTSEKERLETKLKTALDHVDQLQSQLLSYEKEIEDLVHSNRDKTKQCESLKEE-NNQLCMTITQEKE-------------QKKELKNCLEHLKGAEANLTLRLQNEQRQNSDLMKELEE----------QKRLFQTLQAKQK----ESDEENQKLRKEKDSFLRRLSHPRDVS--SSVSQAQAFVPAPEDFVFGN----------------------------------------------------------------------------------------------------------PYHAAGANQEARATGIDSIRKCPICNDIFPDDIETRDYE---------------------------------AHVQSHLLECPVCNEAFEKSNQQVFDDHMLCHSLE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Anolis carolinensis _CALCOCO2 ---------------------DEPPTSAVLLD------TCHFSQVIFT-------DVEKFYVPGGDITCHYNLSQQIIPRSKDWVGIFRVGWKTTREYYTFMWAPLPSN-ANSSDAELQQVLFKAYYLPKDD-EYYQFCYVDQDGQVRGASVPFQFRA-EAEDDMLVVTTQGEVEETMQQNTALLQENQKLKEKQ--------------VSLQKQNEDLQKKLK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Danio rerio _CALCOCO2 ------------------------MSDRTEEESIVIMETSSFSQVVFN-------DVPPSYPPNTAVTCRFTTG-DLQPNPRDWIGIYKVGWNSAQQYYNYVWVEAPHL----DQAKPEQVIFKESYLPKDDGEFYQFCYVDSSGHVKGASTPFCFQNQET------SLDCSLEK-----DLLVITTQE---------------------QTEIMEKEKEDFLKEIESLKETNTILRNELDERLHEMSRLRSTLEDLKSKDKPETPLPD-----------------------EQSYNAIEESLTPLQEK-------YEKAVQKIFVLKQERTELQQQIELQDTEILRLSTLLKEMEQNYSKVQDQAKLLQLDVQSSRKDNEKLQMEIQELR----------------------------------------------------------KDCRAENKALQTSMLEQRAQENDK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Takifugu rubripes _CALCOCO2 --------------------------MDSCAKTPETPSNLIFSQVVFI-------DIPHSYPPAAPLTCCYTVTAAFQPSNKDWVGIFRVGWSKTRDYHTFVWVDSSQD-GTGHQSEIRQAVFNDYYLPKDEIEFYQFCYVDGAGQVRGASTPFCFRKSVE-----QNTESSPDD-----NLLVVTTQKAFISLQR--------------QNEQKEKENSQLVEELGQIKKENENLKSTSEQQMKEMERLKNINGKLRLNFKFKNEERE------------------------------LFQMKDCVQL-------LKISEEEKEGLSAELQRLQSLACNMDDMMRKS---QELCSRLSQQESGQNENLKVRCQALAAQLTDAQAKLAAAKEQSKNAERSAEQLKEELEEVKEKLAD----------------------------VVSSHEKAQQKSGKQETDNAALIEEKERLIAILSNEKRELAQQN----------------------------------------------------------------------------------------------------------------------QAAPPAGTTEDPADQHHRETSEQSEGLCKNTG-----------------------------------------------------------------HFVMCRHCQESFSFITQVELEQHEQSHRICPFCQMVCDDMDQS------VFEDHVYSHEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Homo sapiens_TAX1BP1 ----------------------MTSFQEVPL------QTSNFAHVIFQ-------NVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEH-YVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSP-VEELLTMEDEGNS-----DMLVVTTKAGLLEL----------------KIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQ---------------------SLKMENEEFKKRFSDATSK-------AHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAE-KENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELK---------LNAMK----------------------------------------------------------------------KDQ---------DKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNN-----------------NVFTKKTGNQQKVNDASVNTDPATS--ASTVDVKPSPSAA-EADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAK-----CNKYADELAKMELKWKEQVKIAENVKLELAEVQDNY------------------------KELKRSLENPAERKME------------------------------------------------------------DGADG---------------------------------------------------------------------AFYPDE-IQRPP--------------------------VRVPSWGLEDNVVCSQPA--RNFSR-----------PDGLEDS-----------EDSKED----------------ENVPTAPDPPSQHLRGHG--TGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHW-KVCPMCSEQFPPDYDQQVFERHVQTHFDQNVLNFD--- >Mus musculus_TAX1BP1 ----------------------MTSFQEVQL------QTSNFAHVIFQ-------NVAKSYLPNAHLECHYTLTPYIHPHSKDWVGIFKVGWSTARDYYTFLWSPMPEH-YVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRAASP-VEELLTMEDEGNS-----DMLVVTTKAGLLEL----------------KIEKTLKEKEELLKLIAVLEKETAQLREQVGRMERELSQEKGRCEQLQAEQKGLLEVSQ---------------------SLRVENEEFMKRYSDATAK-------VQQLEEDIVSVTHKAIEKETDLDSLKDKLRKAQHEREQLECQLQTEKDEKELYKVHLKNTEIENTKLVSEIQTLKNLDGNKESMITHFKEEISKLQSSLAD-KENLYRALLLTTSNKEDTLFLKEQLRKAEEQVQATRPELIFLTKELSDAVNVRDKTMADLHTARLENERVKKQLADTLAELQ---------LHAVK----------------------------------------------------------------------KDQ---------EKTDTLEHELRREVEDLKLRLQMAADHYREKFKECQRLQKQINKLSDQAASTN-----------------SVFTKKMGSQQKVNDASINTDPAASTSASAVDVKPAASCA-ETGFDMSTKDHVCEMTKEIAEKIEKYNKCKQLLQDEKTK-----CNKYAEELAKMELKWKEQVKIAENVKLELAEVEDNYKVQLAEKEKEINGLASYLENLSREKELTKSLEDQKGRKLEGQ-----SPQQVS------------RCLNTCSEQNGLLPPLSSAQTVLQYGNPYSAQETRDGADG---------------------------------------------------------------------AFYPDE-IQRPP--------------------------VRVPSW--EDNVVCSQPA--RNLSR-----------PDGLEDP-----------EDSRED----------------ENVPIPPDPANQHLRSHG--AGFCFDSSFDVHKKCPLCELMFPPNYDQTKFEEHVESHW-KVCPMCSEQFPPDYDQQGFERHVQTHFDQNVLNFD--- >Rattus norvegicus_TAX1BP1 ----------------------MTSFQEVPL------QTSNFAHVIFQ-------NVAKSYLPNAHLECHYTLTPYIHPHSKDWVGIFKVGWSTARDYYTFLWSPMPEQ-YVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRAASP-VEELLTMEDEGNS-----DMLVVTTKAGLLEL----------------KIEKTLKEKEELLKLVSVLEKETAQLREQVGRMERELSHEKSRCEQLQAEQKGLLEVSQ---------------------SLRVENEEFMKRYSDATSK-------AHQLEEDIVSVTHKAVEKETELDSLKDKLRKAQQEKEQLECQLKTEKDEKELYKVHLKNTEIENTKLVSEIQTLKNVDGNKESMITHFKEEIGKLQSCLAD-KENLHRALLLTTSNKEDTLLLKEQLRKAEEQVQATRQELIFLAKELSDAVNVRDKTMADLHTARLENERVKKQLADTLAELQ---------LHAVK----------------------------------------------------------------------TDQ---------EKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSASSN-----------------GVFTKRMGSQQKVNDASINTDPAAS--ASAVDVKPAASCAAETDFDMSAKDHVCEVTKEMAEKVEKYNKCKQLLQDEKAK-----CNKYADELAQMELKWKEQVRIAENVKLELAELEDSYSLQLAEKDKEINCLASFLENLSREKELTKSLEDQKGRKMEGQ-----SPQQVS------------RCLNTCSEQSGLLPTLPAAQPVLQYGNPYTAHETRDGADG---------------------------------------------------------------------AFYPDE-IQRPP--------------------------VRGPSW--EDNVVCSQPA--RNLSR-----------PDGLEDP-----------EDSRED----------------ENVPIPPDPANQHLRGHG--AGFCFDSSFDVHKKCPLCELMFPPNYDQIKFEEHVESHW-KVCPMCSEQFPPDYDQQGFERHVQTHFDQNVLNFD--- >Bos taurus_TAX1BP1 ----------------------MTSFQEVPL------QTSNFAHVIFQ-------NVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEH-YVEGSAVNCELAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRAASP-VEELLTMEDEGNS-----DMLVVTTKAGLLEL----------------KIEKTMKEKEELLKLIAVLEKETTQLREQVGRMERELNHEKERGDQLQAEQKALTKVSQ---------------------SLKMENEEFKKRYNDVTSK-------ALQLEEDIVSVTHKAIEKETELDSLKDKLKKAQCEREQLECQLKTEKDEKELYKVHLKNTEIENTKLVSEVQTLKNLDGNKENMITHFKEEISRLQFSLAE-KENLQRTFLLTTSSKEDTFILKEQLRKAEEQIQATRQEAVFLAKELSDAVNVRDKTMADLHTAHLENEKVKKQLTDALAELK---------LSAVN----------------------------------------------------------------------KDQ---------EKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANSN-----------------SVFTKKIGSQQKVNDASINTDPAAT--ASTVDVKPLPSTA-ETDFDNLTKGQVSEMTKEIADKTEKYNKCKQLLQDEKTK-----CNKYADELAKMELKWKEQVKIAENIKLELAEVVDNYKLQLAEKEKEISGLTSYWENLSREKEHKRSVENQAERKLEGQN--SQSPHQIS------------QCLKTSSEKSGHVPAVSNTQPVLQYGNPYATPETRDGADG---------------------------------------------------------------------AFYPDE-IQRPP--------------------------VRVPSWGLEDNVVCSQPA--RNLSR-----------PDGLEDP-----------EDSKED----------------EKVPTAPDPPSQHLRGHG--TGFCFDPSFDVQKKCPLCELMFPPNYDQSKFEEHVESHW-KVCPMCSEQFPPDYDQQVFERHVQTHFDQNVLNFD--- >Canis familiaris_TAX1BP1 ----------------------MTSFQEVPL------QTSNFAHVIFQ-------NVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEH-YVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRAASP-VEELLTMEDEGNS-----DMLVVTTKAGLLEL----------------KIEKTMKEKEELLKLIGVLEKETTQLREQVGRLERELNHEKERCDQLQTEQKDLIEVSQ---------------------SLKTENEEFKKRYNDATSK-------ALQLEEDIVSVTHKAIEKETELDSLKDKLRKAQYEREQLECQLKTEKDEKELYKVHLKNTEIENTKLVSEVQTLKNLDGNKESMITHFKEEIGRLQFCLAE-KENLQRAFLLTTSSKEDTFFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDKTMADLHTARLENEKVKKQLADALAELK---------LNAVK----------------------------------------------------------------------KDQ---------EKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANSN-----------------SVL-KKIGNQQKVNDASINTDPATI--ASTIDVKPAPSAA-ETDSDIVTKGQVCEMTKEIADKTEKYNKCRQLLQDEKTK-----CNKYADELAKMELKWKEQVKIAENVKLALAEVEDNY------------------------KELKRNLEDQAERKME------------------------------------------------------------DGADG---------------------------------------------------------------------AFYPDE-IQRPP--------------------------VRVPSWGLEDNVVCSQPA--RNLSR-----------PDGLEDP-----------EDSKED----------------ENVPTAPDPPSQHLRGHG--TGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHW-KVCPMCSEQFPPDYDQQGFERHVQTHFDQNVLNFD--- >Equus caballus_TAX1BP1 ----------------------MTSFQEVP-------QTSNFAHVIFQ-------NVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEH-YVEGLTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRAASP-VEELLTMEDEGNS-----DMLVVTTKAGLLEL----------------KIEKTMKEKEELLKLIAVLEKETTQLREQVERMERELNHEKERCDQLQSEQKGLIEVSQ---------------------SLKMENEEFKKRYNDATSK-------ALQLEEDIVSVTHKAIEKETELDSLKDKLRKAQYEREQLECQLKTEKDEKELYKVHLKNTEIENTKLVSEVQTLKNLDGNKESMITHFKEEIGRLQLCLAE-KENLQRAFLLTASSKEDTVFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDKTMADLHTARLENEKVKKQLADTVAELK---------LNAVK----------------------------------------------------------------------KDQ---------EKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNN-----------------SVFTKKIGNQQKVNDASINTDPAAA--ASTVDVRTPPSAA-ETDFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKTK-----CSKYADELAKMELKWKEQVKIAENVKLELAEVEDNY------------------------KELKRSQENKAERKMENQN--SQSPQQIS------------QCLNTCPEQNGHVPTVPNTQPVLQYGNPYATQETRDGADG---------------------------------------------------------------------AFYPDE-IQRPP--------------------------VRVPSWGLEDNVVCSQPA--RNLSR-----------PDDLEDP-----------EDSKED----------------ETEPTAPDPPSQHLRGHG--TGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHW-KVCPMCSEQFPPDYDQQGFERHVQTHFDQNVLNFD--- >Monodelphis domestica_TAX1BP1 ----------------------MTSFQEVPLSS--TLQTSNFAHVIFQ-------NVAKSYLPNAHLECHYTLTQYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEH-YVEGATVNCLLSFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSP-VEELLTMEDEGNS-----DMLVVTTKAGLLEF----------------KIEKTMKEKEELLKVTTVLEKETAQLREQVGRLEKELNHEKERCDQLQAECKGLVEASQ---------------------NLQVESEELKKKHSEATSK-------VLQLEEDLMTVTQRAITKETDLDNLKDKLKKVTLEKEQLECQLKTEKDEKELYKVHLKNTEIENTKLVTEVQTLKNLDGNKETMIAHYKEEVGRLQLCVAE-KENLQRAFLLTTSNKDDAANLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDQTMADLHSARLENEQVKKQLAETVAELR---------VAVVK----------------------------------------------------------------------KQQ---------EKIDPVEQDLRREVEDLKLRLQMAADHYKEKFKECQRLQKQVTRLSDQAVSSS-----------------DIFIKKTGNQQKVMDASSNTEIADP--PITIKLSAVGPATSEMVSEMVTKGQVCEMTKEIAEKTEKYKKCKQLLLDERAK-----CSTYADELAKMELKWKEQVKISEDLKLHLAEAEVQY------------------------KVLKKRLENPAERVME------------------------------------------------------------DGADG---------------------------------------------------------------------AFYPDE-IQRPP--------------------------VRTFLWELEDNVVCSQPA--RNLSR-----------PDGLEDP-----------EDSNDDD---------------ENVLPAADPPSQLLHAHR--TGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHW-KVCPMCSEQFPPDYDQQGFERHVQTHFDQNVLNFD--- >Ornithorhynchus anatinus_TAX1BP1 ----------------------MTSFQEVTLPS--ALQTSNFAHVIFQ-------NVAKSYLPNAHLECHYTLTQYIHPHQKDWVGIFKVGWSTARDYYTFLWSPMPEN-YVEGSTVNCLLSFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRTSSP-VEELLTMEDEGNS-----DMLVVTTKAGLLEF----------------KIEKTMKEKEELLKITTVLEKETAQLREQVERLEKELNHEKERCDQLQIEQKDLIEASQ---------------------SLNTENEELKKNCNDATSK-------VLQLEEDIMTVTQKAIAKETELDCLKDKLKKIAFEREQLECQLKTEKDEKELYKVHLKNTEIENTKLVTEVQTLKNLDGNKENIIAHYKEEVGKLQQCMAE-KENLQKAFLLTVPNKEDDSFLKEQLRKAEDQVQATRQEVVFLTKELSDAVNVRDRTMADLHSARLENEKVKKQLAEAMAGLK---------VTIVK----------------------------------------------------------------------SEP---------EKTDTVEQELRREVEDLKLRLQMAADHYKEKFKECQRLQKQVNKLTDQSVSNLSY-------------LLNSFSKKTGSQQKVTDASINTDGASA--SADVKSTPAGIST---ISELKTKGQVCEMTRAIAEKTEKYRKCKQLLLDEKAK-----CNGYADELAKLELKWKEQVKISDNVKLQLAKMEDHF------------------------KELKGRLDSQAEGIVN------------------------------------------------------------DGADG---------------------------------------------------------------------AFYPDE-IQRPP--------------------------TRTSPWGLEDNVVCSQPA--RNLSR-----------PDGLEDL-----------DDSNDDD---------------ENVLTVPDPQSQLLHEHG--SGFCFDSSFDVRKKCPLCEVMFPPNYDQTKFEEHVESHW-KVCPMCSEQFAPDYDQQRFERHVQTHFDQNVLNFD--- >Gallus gallus_TAX1BP1 ----------------------MSSFQEVPSSAN-ALQTSNFAHVIFQ-------NVAKSYLPNTHLECHYTLTQFIHPHQKDWVGIFKVGWSTARDYYTFLWSPMPEN-YVEGSTVNCVLNFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRTSSP-VEELLTMEDEGNS-----DMLVVTTKAGLLEF----------------KIEKIVKEKEELLKVTSVLEKETAQLRDQVERLEKELNLEKQRCDQLQTEQKTNIQASE---------------------SLKTENDDLKKKHDEVASK-------VLQLEEDIMTVTQKAIAKETELDSMKDKLKKVMLEKEQLECVLKTEKDEKELYKIHLKNTEIENTKLVKEIETFKNLDANKENMISYYKEEVGRLQLFIAE-KENMKKAFLLTSSNKEDAAILKEQLRKAEDQIQASKQEAVLMSKELSDAVNVRDKTMADLHSARLENEKLKKQLADALAELKK--------ITALK----------------------------------------------------------------------NEQ---------ETSNTTEQELRREVEDLKLRLQMAADHYKEKFKECQKLQKQVNKFTEQ-------------------------AKIVGNQQKLTDASNTVTATAIVTDKKLPASPVSPISSDVVSEFMVKEQVREMNKEIAEKTEKYKKCKQMLAGEKMK-----CSAYADELAKLELKWKEQVKINESIKLQLAAMEDQYKVQLAEKERRIKELASQLELFTAEKELGKTAGNQAGRMMEGQI--S---QPTL------------HFRNPYSEENGPVPAVPSRLPVLQYGNPYAIQERRDGADG---------------------------------------------------------------------AFNPDE-IQRPP--------------------------ARTSFWGLEDDVVCSQPS--RNLSR-----------PDGLEDP-----------EDSNDDD---------------NTAPSAPDPPSILLHERG--TGFCFDSSFDVRKKCPLCDLMFPPNYDQSKFEEHVESHW-KVCPMCSEQFPPDYDQQGFERHVQTHFDQNVLNFD--- >Anolis carolinensis _TAX1BP1 ----------------------MSSFQEIPSSSS-ALQTSNFAHVIFQ-------NVAKSYLPNVHLECHYTLTPYIRPHQKDWVGIFKVGWSTARDYYTFLWSPMPEN-YVEASTVNCVLSFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRTSSP-VEELLTMEDEGNS-----DMLVVTTKAGLLEF----------------KIEKTLKEKEDLLKVTASLEKETAHLREQVERLESELNYEKEKFDQLEAQQKDNFKTVE---------------------ALKTEKDGLKKKYDEATSK-------VLQLEEDIMTVTQKAIAKETELDSFKDKLKKVILEKEQLECQLKTEKDEKELYKIHLKNTEIENTKLASEVQTLKNLDGNKENLISYYKEEIGRLQLCVAE-KENLKRAFLLTSSNK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Xenopus tropicalis _TAX1BP1 ----------------------MSALQEIPSPIS-NMQTSNFAHVIFQ-------NVAKSYLPNAPLECHYTLTQYIHPHPKDWVGIFKVGWSTPRDYFTFLWSLMPEK-YVAESTCNCVLTFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSP-VDELLTMEDEGHS-----DMLVVTTKTGLLEL----------------KIEKTMKEKEELVKITTVLEKEVLQLREHVEGLESEFLREQKRSEQLSSEREELFNASE---------------------ILRNESDEAKRKCKEMSAK-------IIQLEEDIMLVTQKAIAKETELDSLKDKLKKVVLEKDQLECQLKYEKDEKDLYKVHLKNTEIENTKLLTEVQTLKNLDTNKENLISHYKEELGKLQICLAD-KEKMNKELLQNSSNKEDIAFLKQQLRKLEDQHQASRQEVSLMSRELSEAVNKRDKTMADLHSARLDTDSVRMQLADALAQLSMRDEQQQKSNPFAK----------------------------------------------------------------------KDQG--------ADNNRVEQELRKEVEDLKLRLQMAADHYKDKFKECQKLQKQVVKLTEQLKATE-------------------------NQQKERELFCATEAAAVT-VMKQCTPPVSPFTSDSLPEFDIREQVREMSLEMAEKTEKYRKCKQMLAEEKAR-----CSAYADDVAKMELKWKEQLKVNDSIKRQLIALDDQYKVQSAEKDREICDLSYSIETLRNEKAKMERFINDLEKKLEKQAGWAASNTQGL------------QFFNPYCDEHRLAPAIPAQQPLLQFGNPYASQETRDGADG---------------------------------------------------------------------AFNPDE-VQGPP--------------------------VRATSWGLEDKVVCSQPA--RNLSR-----------PDGLEDPDENNAGLITKDEDDDDDD---------------DNVNFEQTPDPTRIAMHDQ-SGFCFEAGYTMNKKCPLCPVSFPPNYDQGQFEAHVESHW-KVCPMCNEQFPPDCDQQIFERHVQTHFDGSVLNFD--- >Tetraodon nigroviridis _TAX1BP1 ------------------------------------METSNFAHVIFQ-------NVGKSYLPHGALECHYTLTQFIKPHPKDWVGIFKVGWSTARDYYTFLWSPLPDN-YTEGTAINRSVVFQGYYVPNDDGEFYQFCYVTHKGEIRGASTPFQFRANSPTEEELLTMDDEGGS-----DILVVTTKASYLEQ----------------KMEQIQQEKKELLENLDLLQKERDELIDEKNRLEKEYEQERESSAQLRKDVQELQLSAQ---------------------SLQEEREEVKRRMEESTAR-------LLQLEEDLIGVTQKGLQKETELDCLKDRVKKLNLEKEALEGQLKNEKDEKELYKIHLKNRELENTKLSAELQMLKSVDVNKENTIAQLKDELARVKSCLAE-KEKQHRQLLANSSPSGESKALREQLRQKEEQLQATQQQANMLKAELRDSSNARDRSMAELYRIRVEAETLKKGQADAKAECSRLEQQLEEMKSSTQ----------------------------------------------------------------------HEAQCK------ESDVLAVAELQREVEDLRLRLQMAAEHYKDKYKECQKLQKQVVKFSEQQG-----------------------------VKRSPGSDAAAGPLSA---SPEASAPGSPSTSDAVLDAIIHGRLKSSSKEL-DKNDKYRKCKQMLNEERER-----CSMITDELTKMEVKLREQMKTNESLRMQLAAEEDRYKSQVAEKGRELKELKDSLFVLTKEKEKLEGQLQKSVNREEEQKDSNLDVQSVF-----------LQYPMPYAQDDPSPLLVPQRPTDLLFGNPYSSTDSRDGADG---------------------------------------------------------------------EFSDDQMPRLPP--------------------------VGPPSW--DSNVVCIQPA--RNLSR-----------PDGLEEP-----------EEPQST----------------QNDDEPAAPEPAEFLNDGQ-MPFCFEPTGEQKR-CPLCEVIFPPHYDQSKFEEHVESHW-KICPMCSEQFPLDCDQQLFEKHVLTHFDSNVLNF---- >Danio rerio_TAX1BP1 --------------------------LDG-TLQN-DMDTSNFAHVIFQ-------NVGKSYLPHAALECHYTLTQFIRPHPKDWVGIFKVGWSTARDYYTFLWSPLPEN-YVEGTGVHRTVVFQGYYVPNDDGEFYQFCYVTHKGEIRGASTPFQFRANSPSADELLTVEDECNS-----DILVVTTKAGFLEQ----------------KVEEIQREKEELVKKVALLEQEKEQLEAEKENLKKECEEEKETCAQLRRENQEVQSSSQ---------------------ALQEEKEEVKRRLEEANAR-------VVQLEEDLIGVTQKGLQKETELDNLKDRLKKFTVEKEALESQLKNEKDEKELYKIHLKNRELENTKLSAELQMLKSVDVNKENTIAQFKEEVGRLQACLTE-KDKQYREILAKVSPLADIKVLKEQLRQKEEQLQANQQQLSLLAAELRDTSSTRDRTMSELYHMKLEADTLRQAKAEAQAQS---------TQAKAA----------------------------------------------------------------------EEET---------ADPAVVAELQREVEDLKLRLHMAAEHYKEKYKECQRLQKQVLRLSEQQGGKT-------------------LHFVLIPNRQENRNEALIIPATL---SPDTSVPGSPGSADPMLEVIIQEKLKGISREASDRNDKYRKCKQLLMEEKDR-----SCMYADELAKLELKFKEQLKTNENLKLQLAAEEDRYKSQVAERGRELKELKDTLALVCKEK-------NSKRSTEEERAIRGAARKPVWR--------VTSPYPVPYTQDAPTPLLVAQSPSKLQFGNPYSISDPKDDEDE---------------------------------------------------------------------EFSDNQLLRLPP--------------------------VGPPSW--DSNVVCIQPT--RNPSR-----------PEGHEEP-----------EEKQNN--------NNNND--NPNKEPPAAETRSTFVNDGQ-TAFCFDPSMDMKR-CPLCEVIFPPNYDQNKFEEHVESHW-KICPMCSEQFPLDCDQKVFEAHVLTHFEGHQLNFD--- >Takifugu rubripes _TAX1BP1 ----------------------MALILDRTSLSN-NMDTSNFAHVVFQ-------NVGKSYLPHAALECHYTLTQFIIPHPKDWVGIFKVGWSTARDYYTFLWSPLPEN-HVEGTAVNRTVVFQGYYVPNDDGEFYQFCYVTHKGEIRGASTPFLFRASSPTEDELLTVEDECNS-----DILVVTTKASFLEQ----------------KVEEAQREKDELLKNMAVLEQEKEQLQAEMEALQKECEQQKETCTQLRRENQEVQHSSQ---------------------ALLEEKEEVKRRLEEATAR-------IVQLEEDLIGVTQKGLQKETELDGLKDKVKKLTTEKEALEIHLKNEKDEKELYKIHLKNRELENTKLSAEMQMLKSVDVNKENTIAQFKEEVGRLQACLTE-KEKQHRDILARVTPLGEMKALKEQLRQKEEQLQATQQQSSLLAAELRDASSARDRTMSELYQMKLEADALRQAKADAQSQCVHLEAQVEQLKAEAK----------------------------------------------------------------------QEAA--------AADLAVAAELQREVEDLKLRLHMAAEHYKDKYKECQRLQKQVLKLSDQQGV---------------------GSAEHQEPKKISAQDVPMVLATG---SPDTSVPGSPGSADPMLEAIIQEKLKGISREASDRNDKYRKYKQMLMEEKER-----SCMFVDELAKMEAKFKEQLKINENLKLQLAAEEDRYKSQVAEKGRELKELKDTLGLILKEKEKLEMNVSNCRCKVNEEAQSGSSRKGEQ----------GAKYPVPYTQDTPTPLLVSQSPSKLHFGNPYSILDSKDETEE---------------------------------------------------------------------EFSNEQ-LRLPP--------------------------VGPPSW--DSNVVCIQPT--RNPSR-----------PEGHKES-----------EENNNEPHQSACSFDNMDYDVNTNEKPTAAETRSPFVNDGQ-AAFCFDPSMDMKR-CPLCEVIFPPNYDQSKFEEHVESHW-KICPMCSEQFPLDCDQKVFENHVLTHFDGQPLNFD--- >Gasterosteus aculeatus_TAX1BP1 ------------------------------------MDTSNFAHVIFQ-------NVGKSYMPHAALECHFTLTQFIKPHPKDWVGIFKVGWSTARDYYTFLWSPLPEN-YEEGTAVNRIVVFQGYYVPNDDAEFYQFCYVTHKGEIRGASTPFQFRANSPSEDELLTVEDECNS-----DILVVTTKAGFFEQ----------------KLEEAQREKEELIKNMGLLQQEKEQLQAEKESLHKECEQEKESCALLRRESQDLQNSSQ---------------------ALQEEKMEVKSRLEEATAR-------VIQLEEDLIGVTQKGLQKETELDSLKDRVKKLTAEKEALESHLKNEKDEKELYKIHLKNRELENTKLSAELQMLKSVDVNKENTIAQFKEEVGRLQACLTE-KEKQNREILAKVPPLGDVKALKEKLRQKEEQLQANQQQSSLLAAELRDASSTRDRTMSELYHMKLEADALRQAKAEAQAQCGRLERLVEQMKAEAK----------------------------------------------------------------------TEAAKKEEEEEAAEDPAVLAELQREVEDLKLRLHMAAEHYKEKYKECQRLQKHVLRLNDQQG----------------------------DVKRSTAQEASTIPVSV---SPDISVPGSPGSADPMLEAIIQEKLKGFSREATDRNDKYRKCKQMLLEEKER-----NCMFADELAKMELKFKEQLKMNENMKLQLASEEDRYKSQVAEKGRELKELKDALALVVKRKEKVEGELQKEGDQGGSEKTSLENIQSIVP--------LFLQYPVPYTQDAPTPLLVSQSPSKLHFGNPYSIPDSKDEGDE---------------------------------------------------------------------EFSDDQLLRLPP--------------------------VGPPSW--DSNVVCIQPA--RNHSR-----------PEGHEES-----------EEKQNN--------NNNNVRVMPANTPAAAETRSPFVSDG----------MDMKR-CPLCEVIFPPNYDQSKFEEHVESHW-KICPMCSEQFPLDCDQKVFENHVLTHFDCQPLDF---- >Oryzias latipes_TAX1BP1 ------------------------------------METSNFAHVIFQ-------NVGKSFLPQAPLECHYTLTPYITPHPKDWVGIFKVGWSTARDYYTFLWSPMPEK-YEQGSTVHRTVVFQGYYVPKSDGEFYQFCYVTHAGDIRGASTPFQFRSATPTEELLTVTEDDSNS-----DILVVTTKTGLLEQ----------------HVEEAQQERRELLKAMQLLQEEKQQLQEEQRRLAREREQERETCCLLRTHNQELLRSSQ---------------------GLSEEREEVRKRLTEATDR-------VRQLEEDLLSVTQRGLQKETELDRLRDHLKKLTAERDSFESQLKNEKDERDLYKAHLRSTELENTKLSAELQMLKAVELNREVTIAQFQEELERLRACVAQ-RDSLEKELQANKAEKAELAHVREQLRQAEEQLQASRQQANLLASELRDSATTRDHTMTELYCARVEANKLRASLADAQAECQR-------MENQLD----------------------------------------------------------------------RMRS-------TAEKVVAEAELQREVEELKLRLHMAAEHYKEKYRECQRLRRQVAKLNTPESQTS----------------------KVIVNRTLGKQQGRHTSISTNNTYSQQYDTKNRNRAVAHFHGMTTAEGAAKARDVAQRVWLESEGRPLGETDREQ-----THSVEEELAMMEEKWREQCVINETLKQRLADEEERFRVQIAERAREVTELKRNLAKAIRDKEQLQEVKQQIFGSSESE------------------------MCPITAYKIQIMSLESGRPADLQYGNPYSTDTTKDHVDV---------------------------------------------------------------------ASCPENMARPPPEA------------------------PRSGARGWNQEVVCIQPS--RSTTP-----------PENMEHPP----------PDTRNFS------------KASDGAPLTCDHQSGRLSETR--GSFCFDSRSDVHKRCPLCEVIFPPHFEQRSFEQHVESHW-KVCPVCAEQFPLNCQQQLFERHVLTHFDGHVLNFE--- >Branchiostoma floridae (XP_002238600) -------------MASAEPLPEVPSFEDRPNPPNKSMSHSDFAQVLFH-------NVADSYVPGVDIPCRYTLTPLMTPRSRDWVGLFKIGWSSPRNYTTFAWSPLPAE-TEEGKDRENCVVFKAYYLPNDDGEFYQFCYVTSSGEVRGASTPFQFKPRRS--IDYVEVPDETG------EMLVIKERTTVLEE----------------NLQKALADKEALLNDKETFEEKVHSLQRNIQELEGTLAEESDKRETLENEYKECQEQLA---------------------SEQQLSQEHKQSSDKANNE-------LGLMRVMLEDVNRKLVEKATEIEKLRSEIRAVRVERDQLGVKLRNEQEEKELFKSHFTASELENKERSREIRELKNLVREKEFSIEKFKLEITKLNQNIKEGSKKLQRQESISQADKEHMKGLEERVRNTEDKLAAAEQSKLLLAEELSTVSDVRHKVHSDLETAVLQADTLKMRLKKAEESYAKKEKDLLDEMSVLRGGLDEILQDKDKIEAELKKFKEEVATTSESTQTSEGKPKAVKEDQALFFLETAHHNLEERYKDLQKEYEQLQREKLQIEREKESLVQSEDDLKHQVDDLKVRLEMGAEAYREKYRECHKLEKSIKKLGGGKVKRERSNSTEPTIKVTKEECTEEVGKETKEEETTAEPKETRVEETVSVGQSDPGAEEAEKSSPEFDMTELQTQLTDLHHELQNRYVKVRKYKQLYMEERQRNLD-LVQEQQEKVTTLERQLEEERRQRQEEKSAYDANIQRWSQKLDHLRERIRCQTEHVEDMKSYRRSLEDRVEELQSQVEEYKQYKDAWEDPILDGEETEPLLPASSPRPEDDDTSEDPPPPADFPPLRYPNPYLSQSVQESLEYPHPSPVYPKTCAEYPQYPEPAPPPAEAVPIPVFRQYKGTLWTEKGTDSAEGWTLVQKPASRDYSEFSTPPSSPEPSIDPTPPLTPLPPPLMPTPTAEAKLAAIKAVNMSCSSSSNSSNGSCEDLS--NQEPRSLDDMANGNTEPEATANETEAARVASPIQQEPEDGCEERWMLAQREQEEEEEGENAVARTQSSIPESDSHDDEYGPRTNIADYPQCPVCEVYFPPGCNTDTYDLHVQSHYGRTCPMCNNFFDDNTTESAFIDHVQSHFDHEG------- >Ciona intestinalis (XP_002120135) ------------------------------------MGISTFSQVIFP-------DIPDFFPPEKDVTVSYILT-EIEPTSRDWVGLFRVGWASPRDYTTYVWSPKPRL--DESGNLSQCITFKAYQLPKDDSEFYQFCYVTRNGYVRGASTPFQFRLCTE-NDCLVEVEDES-------GMIILKTKSDALED----------------QLSKVNQEKKLLEVEMESLIQSKENLETSLKKVSTELSSAEEKYRSCDDKNKELQASLG---------------------EATAEQVKLLQRLEKAEKR-------IEKTKCDLATAQTTIDKLHQDIKSLEAEVAAAKQDRMLEKVNYEEEIKIRELMMQEKNVEMNGLRDEIKTLFTIKEEMQQKSNLELNDREDAFKVVSKENE------TVRNKCASYKEERDLFKDQFTKSELARNEALKDKAVLEQKLDVAMRGAELQQEKVDAADEKIKIIKKEWKDLNKQHK-------------------------------------------------------------------------------------------------QELNQLQGTLRNSTERANALEAAKKLLTNELSDTTATRDQLMTDLNLIKKEKENLVEELKG----------ATSMVSALQCQLETLESKLTLSEKSLVDKDRMMLDERRRGEIAEDEMHQQLLLLRKQLEESDNAMAIVTSQKENSSTKDQKTQTQKKKDSVQAQAPKIEEQEFVINDLRSQVEDLTTRLSMGADAYKEKFVECHKLEKKVKKLKLIHKSTSSANVPLKTSTTTDGESTMQSNDGIMNKLEKLFLSIADPDAEEQEQTLKLQQKVDEMVKAVDTEHARYRKYKQLY--------------------------------------------------------------------IEEKQRSATKLAAATCKQDELQLRYEDEMERCKMLDDENMMLKTQLNEFIESSTDAAVRNVMTGTPQKERSREILDDESQFQDAQEFPMLSTKSDYSASSDSNDDGLSYAGAAKAGFTNLCSKDIPTYSSEGKSDSDETSQPTTTRPVPISAPRKSKVISRQPIRSPPVLSDVVTSSSQSDSTTPSHTEARKKKGKNKKGKSRKSIRPIM-- >Ciona savignyi_CALCOCO (ENSCSAVG_7266) -------MASSEIEASGEMLKSCDVPFIPESSSVYDMAISTFSQVIFP-------DTPDFFPPEKDITVRYILA-EIEPSTRDWVGLFRVGWASPRDYSTYVWAPKPIA--DESGNLSQTITFQAYQLPKDDNEFYQLCYVTRQGYVRGASTPFQFRLCTE-NDCLVEVEDES-------GMIILKTKSDALEE----------------QLSKAKEERNALESEMKLLFQAKVLLEENLKKISEELAMAQEQNRVSEEKKADVVASME---------------------KMTEEYEKVTHRLAKAEKR-------IEKTKADLASAQNNIKELQESMSSLQAQIVAAEQERLQEKINYEEEIKIREMMMLEKDVQMNVLREEIKTMSTIKEEIQQKSSLKVNEQESAFKVVTKENE------NLRVKCQSLKDERDLFKDQFTKSELARNEALKDKASLEEKLQYAIKDAEMQQEKVDAAEEKIKVVEKQWKELNKKHK-------------------------------------------------------------------------------------------------IETNHVQDELRNSSERANALEAAKKLLTQELSDTTATRD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------