>Homo_sapiens_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------V PSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFR---- --ASFPPLETGRNLKKEVSRVL----CKRCALPPRLK----------EMKSQESAAGSK-----LVLRCETS--SEYSSL RFKWFKNGNEL--------------------------------------------------------------------- -------------------------------------------------------------------------NRKNKPQ NIKIQ---KKPGKS--------ELRINKAS---LADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYV-- ------------------------------------------------------SSESPIRISVSTEGANTSSSTSTSTT GTSHLVKCAEKEKTF-------CVNGGE----------------------------------CFMVKDLSNPSRYLCKCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS----------------------------------------------- ---------------------------LRSERNNMMNIANGPHHPNPPPENVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVISSEHIVEREAETS- ---FSTSHYTSTAHHSTTVTQTPS---------------------------HSWSNGHTESILSES------HSVIVMSS VENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA----RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------SSPKSPPSEMSPPVSSMTVSMPSMAV---------SPFMEEERPLLLVTPPRLR EKK-------------------FDHHPQQFS------------------------------------------------- ----------------------------------------------------------------SFHHNPAHDSNSLPAS PLRIVEDE------------------------------------------------------------------------ EYETTQEYEP---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------A QEPVKKLANS----RRAKRTKPNGHIANRLEVDSNTSSQSSNSE------------------------------------ -----SETEDERVGEDTPFLGIQNPLAASLEATPAFRLAD---------------------------------------- -----------------------------SRTNPAGRFSTQEEIQARLSSVIANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Pan_troglodytes_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------MSERKEGRGK---- --GKGKKKERG-SGKKPESAAG----SQSPALPPRLK----------EMKSQESAAGSK-----LVLRCETS--SEYSSL RFKWFKNGNEL--------------------------------------------------------------------- -------------------------------------------------------------------------NRKNKPQ NIKIQ---KKPGKS--------ELRINKAS---LADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYV-- ------------------------------------------------------SSESPIRISVSTEGANTSSSTSTSTT GTSHLVKCAEKEKTF-------CVNGGE----------------------------------CFMVKDLSNPSRYLCKCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS----------------------------------------------- ---------------------------LRSERNNMMNIANGPHHPNPPPENVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVISSEHIVEREAETS- ---FSTSHYTSTAHHSTTVTQTPS---------------------------HSWSNGHTESILSES------HSVIVMSS VENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA----RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------SSPKSPPSEMSPPVSSMTVSMPSMVV---------SPFVEEERPLLLVTPPRLR EKK-------------------FDHHPQQFS------------------------------------------------- ----------------------------------------------------------------SFHHNPAHDSNSLPAS PLRIVEDE------------------------------------------------------------------------ EYETTQEYEP---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------A QEPVKKLANS----RRAKRTKPNGHIANRLEVDSNTSSQSSNSE------------------------------------ -----SETEDERVGEDTPFLGIQNPLAASLEATPAFRLAD---------------------------------------- -----------------------------SRTNPAGRFSTQEEIQARLSSVIANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Gorilla_gorilla_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------RCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS----------------------------------------------- ---------------------------LRSERNNMMNIANGPHHPNPPPENVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVISSEHIVEREAETS- ---FSTSHYTSTAHHSTTVTQTPS---------------------------HSWSNGHTESILSES------HSVIVMSS VENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA----RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------SSPKSPPSEMSPPVSSMTVSMPSMAV---------SPFVEEERPLLLVTPPRLR EKK-------------------FDHHPQQFS------------------------------------------------- ----------------------------------------------------------------SFHHNPAHDSNSLPAS PLRIVEDE------------------------------------------------------------------------ EYETTQEYEP---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------A QEPVKKLANS----RRAKRTKPNGHIANRLEVDSNTSSQSSNSE------------------------------------ -----SETEDERVGEDTPFLGIQNPLAASLEATPAFRLAD---------------------------------------- -----------------------------SRTNPAGRFSTQEEIQARLSSVIANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Macaca_mulatta_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------MSERKEGRGK---- --GKGKKKERG-SGKKPKSAAG----SHSPALPPRLK----------EMKSQESAAGSK-----LVLRCETS--SEYSSL RFKWFKNGNEL--------------------------------------------------------------------- -------------------------------------------------------------------------NRKNKPQ NIKIQ---KKPGKS--------ELRISKAS---LADSGEYMCKVISKLGNDSASANITIVDSNEIITGMPASTEGAYM-- ------------------------------------------------------SSESPIRISVSTEGANTSSSTSTSTT GTSHLVKCAEKEKTF-------CVNGGE----------------------------------CFMVKDLSNPSRYLCKCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS----------------------------------------------- ---------------------------LRSERNNMMNIANGPHHPNPPPENVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVISSEHIVEREAETS- ---FSTSHYTSTAHHSTTVTQTPS---------------------------HSWSNGHTESILSES------HSVIMMSS VENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA----RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------SSPKSPPSEMSPPVSSMTVSMPSMAV---------SPFVEEERPLLLVTPPRLR EKK-------------------FDHHPQQFS------------------------------------------------- ----------------------------------------------------------------SFHHNPAHDSNSLPPS PLRIVEDE------------------------------------------------------------------------ EYETTQEYEP---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------A QEPVKKLANS----RRAKRTKPNGHIANRLEVDGNTSSQSSNSE------------------------------------ -----SETEDERVGEDTPFLGIQNPLAASLEATPAFRLAD---------------------------------------- -----------------------------SRTNPAGRFSTQEEIQARLSSVIANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Mus_musculus_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------MEIYPPDMSEGAGGRSS---- --SPSTQLSADPSLDGLPAAEHMPDTHTEDGRSPGLLGLAVPCCVCLEAERLRGCLNSEKICIVPILACLVS--LCLCIA GLKWVFVDKIF--------------------------------------------------------------------- -------------------------------------------------------------------------EYDS-PT HLDPGG-LGQDPVI--------SLDPTAAS-AVLVSSEAYTSPVS--KAQSEAEAHVTGQGDHVAVASEPSAVPTRKNRL SAFPPLHSTPPPFPSPARTPEV-----------------------------RTPKSGTQPQTTETNLQTAPKLSTSTSTT GTSHLIKCAEKEKTF-------CVNGGE----------------------------------CFMVKDLSNPSRYLCKCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRQKLHDRLRQS----------------------------------------------- ---------------------------LRSERNNMVNIANGPHHPNPPPENVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVISSEHIVEREVETS- ---FSTSHYTSTAHHSTTVTQTPS---------------------------HSWSNGHTESIISES------HSVIMMSS VENSRHSSPAGGPRGRLHGLGGPRECNSFLRHA----RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------SSPKSPPSEMSPPVSSMTVSMPSVAV---------SPFVEEERPLLLVTPPRLR EKK-------------------YDHHPQQLN------------------------------------------------- ----------------------------------------------------------------SFHHNPAHQSTSLPPS PLRIVEDE------------------------------------------------------------------------ EYETTQEYEP---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------I QEPIKKVTNS----RRAKRTKPNGHIANRLEMDSNPSSVSSNSE------------------------------------ -----SETEDERVGEDTPFLGIQNPLAASLEVAPAFRLAE---------------------------------------- -----------------------------SRTNPAGRFSTQEELQARLSSVIANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Rattus_norvegicus_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------MSERKEGRGK---- --GKGKKKDRG-SRGKPGPAEG----DPSPALPPRLK----------EMKSQESAAGSK-----LVLRCETS--SEYSSL RFKWFKNGNEL--------------------------------------------------------------------- -------------------------------------------------------------------------NRKNKPE NIKIQ---KKPGKS--------ELRINKAS---LADSGEYMCKVISKLGNDSASANITIVESNEFITGMPASTETAYV-- ------------------------------------------------------SSESPIRISVSTEGANTSSSTSTSTT GTSHLIKCAEKEKTF-------CVNGGE----------------------------------CFTVKDLSNPSRYLCKCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRQKLHDRLRQS----------------------------------------------- ---------------------------LRSERSNLVNIANGPHHPNPPPENVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVISSEHIVEREVETS- ---FSTSHYTSTAHHSTTVTQTPS---------------------------HSWSNGHTESIISES------NSVIMMSS VENSRHSSPAGGPRGRLHGLGGPRD-NSFLRHA----RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------SSPKSPPSEMSPPVSSMTVSMPSVAV---------SPFVEEERPLLLVTPPRLR EKK-------------------YDHHPQQLN------------------------------------------------- ----------------------------------------------------------------SFHHNPAHQSTSLPPS PLRIVEDE------------------------------------------------------------------------ EYETTQEYES---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------V QEPVKKVTNS----RRAKRTKPNGHIANRLEMDSNTSSVSSNSE------------------------------------ -----SETEDERVGEDTPFLGIQNPLAASLEVAPAFRLAE---------------------------------------- -----------------------------SRTNPAGRFSTQEELQARLSSVIANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Canis_familiaris_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------MSERKEGRGK---- --GKGKK-ERG-SGKKPAPPEG----GQSPALPPRLK----------EMRSQESAAGSK-----LVLRCETS--SEYSSL KFKWFKNGNEL--------------------------------------------------------------------- -------------------------------------------------------------------------NRKNKPQ NIKIQ---KKPGKS--------ELRISKAS---LADSGEYMCKVTSKLGNDSASANITIVDSNDIITGMPASTERAYV-- ------------------------------------------------------SSESPIRISVSTEGANTSSSTSTSTT GTSHLVKCAEKEKTF-------CVNGGE----------------------------------CFMVKDLSNPSRYLCKCP NEFTGDRCQNYV---MASFYK---------------------------------------------AEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS----------------------------------------------- ---------------------------LRSERNNMVNIANGPHHPNPPPENVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVISSEHIVEREAETS- ---FSTSHYTSTAHHSTTVTQTPS---------------------------HSWSNGHTESIISES------HSVIMMSS VENSRHSSPSGGPRGRLNGLGGPRECNSFLRHA----RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------SSPKSPPSETSPPVSSTTVSMPSMAV---------SPFVEEERPLLLVTPPRLR EK--------------------YDHHSQQFN------------------------------------------------- ----------------------------------------------------------------SYHHNPAHESNSLPPS PLRIVEDE------------------------------------------------------------------------ EYETTQEYEP---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------A QEPVKKLTSS----RRAKRTKPNGHIANRLEMDSNASAEGTNSE------------------------------------ -----SETEDERVGEDTPFLGIQNPLAASLEAAPAFRLAD---------------------------------------- -----------------------------SRTNPAGRFSTQEELQARLSSVIANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Felis_catus_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------MEIYSPDMSEGAAERSS---- --SPSTQLSADPSLDGLPAAEDMPETQTEDGRTSGLMGLAAPCCVCLEAERLRGCLNSEKICIVPILACLVS--LCLCIA GLKWVFVDKIF--------------------------------------------------------------------- -------------------------------------------------------------------------EYDS-PT HLDPGG-LGQDPII--------SLDPTAAS-AVWVASEAYTSPVS--RAQSETEVQVTVQVDNAVVSSEPSAVPTPKNRI FAFSFLPSTAASFPFPTRNPEV-----------------------------RTPKSATQPQTTETNLQTAPKLSTSTSTT GTSHLVKCAEKEKTF-------CVNGGE----------------------------------CFMVKDLSNPSRYLCKCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS----------------------------------------------- ---------------------------LRSERNNMVNIANGPHHPNPPPENVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVISSEHIVEREAETS- ---FSTSHYTSTAHHSTTVTQTPS---------------------------HSWSNGHTESIISES------HSVIMMSS VENSRHSSPSGGPRGRLNGVGGPRECNSFLRHA----RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------SSPKSPPSEMSPPVSSTTVSMPSMAV---------SPFVEEERPLLLVTPPRLR EK--------------------YDRHPPQFT------------------------------------------------- ----------------------------------------------------------------SYHHNPAHESNSLPPS PLRIVEDE------------------------------------------------------------------------ EYETTQEYEP---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------A QEPVKKLTSS----RRPKRTKPNGHIANRLEMDSNASAEGTHSE------------------------------------ -----SETEDERVGEDTPFLGIQNPLAASLEAAPAFRLAD---------------------------------------- -----------------------------SRTNPAGRFSPQEELQARLTSVIANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Bos_taurus_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------MEIYSPDMSEGAAERSS---- --SPSTQLSADPSLDGLPAAEDMPETQTEDGRSPGLVGLTLPCCVCLETERLRGCLNSEKICIVPILACLVS--LCLCIA GLKWVFVDKIF--------------------------------------------------------------------- -------------------------------------------------------------------------EYDS-PT HLDPGG-LGQDPII--------SLDPTAASAAVWVSAKAYTSPVS--RAQSETEVRVTVQVDNALGSSEPSAVPTPKNRI FAFSFRPSTAPSLPSPTRSPDV-----------------------------RTPKAATQPPSTETNLQTAPKLSTSTSTA GTSHLVKCAEKEKTF-------CVNGGE----------------------------------CFMVKDLSNPSRYLCKCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS----------------------------------------------- ---------------------------LRSERNTMMNVANGPHHPNPPPENVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVISSEHIVEREAETS- ---FSTSHYTSTAHHSTTVTQTPS---------------------------HSWSNGHTESIISES------HSVIVMSS VENSRHSSPTGGPRGRLNGLGGPRECNSFLRHA----RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------SSPKSPPSEMSPPVSSTTVSMPSMAV---------SPFVEEERPLLLVTPPRLR EK--------------------YDHHAQQFN------------------------------------------------- ----------------------------------------------------------------SFHCNPAHESNSLPPS PLRIVEDE------------------------------------------------------------------------ EYETTQEYEP---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------A QEPVKKLTNSS---RRAKRTKPNGHIAHRLEMDNNTGADSSNSE------------------------------------ -----SETEDERVGEDTPFLAIQNPLAASLEAAPAFRLVD---------------------------------------- -----------------------------SRTNPTGRFSPQEELQARLSGVIANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Loxodonta_africana_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------MEIYSPDMSEGAAERSS---- --SPSTQLSPDPSLDGLPAAEDMPETQTADGRTPGLVGLAAPCCVCLEAERLRGCLNSEKICIVPILACLVS--LCLCIA GLKWVFVDKIF--------------------------------------------------------------------- -------------------------------------------------------------------------EYDS-PT HLDPGG-LGQDPII--------SLDPTAAS-AVWVSSEAYTSPVP--RARSETEVEVTVQGTSAVVSSEPSAAPTPKNRI FTFSFLPSTAPSLSPPTRNPEV-----------------------------RTPKSAVHPQTTETNLQTAPKLSTSTSTT GTSHLVKCAEKEKTF-------CVNGGE----------------------------------CFMVKDLSNPSRYLCKCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS----------------------------------------------- ---------------------------LRSERNNMVNMANGPHHPNPPPENVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVISSEHIVEREAETS- ---FSTSHYTSTAHHSTTVTQTPS---------------------------HSWSNGHTESIISES------HSVLMMSS VENSRHSSPAGGPRGRLNGMGGPREYNSFLRHA----RETPDYYRDSPHSERYVSAMTTPARMSPVDFHTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------SSPKSPPSEMSPPVSSMTVSMPSMAI---------SPFVEEERPLLLVTPPRPR EKK-------------------YDHHPQQFN------------------------------------------------- ----------------------------------------------------------------SFHHNPAHESNSLPPS PLRIVEDE------------------------------------------------------------------------ EYETTQEYEP---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------A QEPVKKLANS----RRAKRTKPNGHIANRLEMDGNTNSESSNSE------------------------------------ -----SETEDERVGEDTPFLGIQNPLAASLEAAPAFRLAE---------------------------------------- -----------------------------CRTNPAGRFSTQEELQARLSSVIANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Gallus_gallus_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------MSEVGTETFP---- --SPSAQLSPDASLGGLPAEENMPGPHREDSRVPGVAGLASTCCVCLEAERLKGCLNSEKICIAPILACLLS--LCLCIA GLKWVFVDKIF--------------------------------------------------------------------- -------------------------------------------------------------------------EYDS-PT HLDPGR-IGQDPRS--------TVDPTALS--AWVPSEVYASPFP--IPSLESKAEVTVQTDSSLMPSRPFLQPSLYNRI LDVGLWSSATPSLSPSSLEP----------------------------------TTASQAQATETNLQTAPKLSTSTSTT GTSHLTKCDIKQKAF-------CVNGGE----------------------------------CYMVKDLPNPPRYLCRCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS----------------------------------------------- ---------------------------LRSERNNVMNMANGPHHPNPPPDNVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NIISSERVVERETETS- ---FSTSHYTSTTHHSMTVTQTPS---------------------------HSWSNGHTESILSES------HSVLVSSS VENSRHTSPTG-PRGRLNGIGGPREGNSFLRHA----RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------TSPKSPPSEMSPPVSSLTISIPSVAV---------SPFMDEERPLLLVTPPRLR EK--------------------YDNHLQQFN------------------------------------------------- ----------------------------------------------------------------SFHNNPTHESNSLPPS PLRIVEDE------------------------------------------------------------------------ EYETTQEYEP---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------A QEPPKKLTNS----RRVKRTKPNGHISSRVEVDSDTSSQSTSSE------------------------------------ -----SETEDERIGEDTPFLSIQNPMATSLEPAAAYRLAE---------------------------------------- -----------------------------NRTNPANRFSTPEELQARLSSVIANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Anolis_carolinensis_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MREAAGKEPGAGAASSSPPSPPEK---- --KRRGKKGKGGAGRRGAQAEQ---EPSGPAIPPKLK----------EMKNQESAVGQT-----LVLRCEAR--SEHPSL KFKWLKNGTEI--------------------------------------------------------------------- -------------------------------------------------------------------------TKRNRPG NIKIKSPKKQKTFS--------ELRITRAS---LADAGEYTCKASNRFGNESTKARISITDEPP--SPKPVLTNGTNA-- ------------------------------------------------------SSQLNDNIPASTEGTNTSSSTSTSTT GTSHLTRCDVNKKGF-------CVNGGE----------------------------------CFMVKDLPNP-RYLCRCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQG----------------------------------------------- ---------------------------LRSERNHRVNMANGPHHPHPPPENVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVISSEHAVERETETS- ---FSTSHYTSTTHHSTTVTQTPS---------------------------HSWSNGRTESIISES------HSALMSSS VENSRHASPSG-PRGRLNGIGGPREINTFLRHA----RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------SSPKSPASEMSPQVSSLTMSVPSVAV---------SPFIEEERPLLLVTPPRLR EK--------------------YEHHIHLFNS------------------------------------------------ ----------------------------------------------------------------SYHHNPGHESNSLPPS PLRIVEDE------------------------------------------------------------------------ EYETTQEYEP---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------T QEPPKKLVNS----RRAKRTKANGHISNRLEIDTDTSCENSSSE------------------------------------ -----SETEDERIGEDTPFLSIQNPVAADLESASAYRLAD---------------------------------------- -----------------------------TRTNQTSRFSTQEELQARLSSVIANQDPIPV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Xenopus_tropicalis_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------LEIYAFKMSEDTAEGLQ---- --NQCSEQSSGPPSAELQNEESMPGTQAEEETTHGITGLAITCCVCLEADRLRICLNSEKICIIPILACLIS--LCLCIA GLKWVFVDKIF--------------------------------------------------------------------- -------------------------------------------------------------------------EYDS-PT HLDPGR-RGQDLIL--------YTDTAPST---LVPSSVRTLPVL--IPTTDAKAPVTLKFGTSLLPTEPTLQPFTPDQI LPKVTSVGKPVPVSTKFPQVES-----------------------------HTTKKVNEPYRLDKNLFCVPALSHGDTTT GPGHLIKCSDKEKTY-------CVNGGE----------------------------------CYVLNGITSSNQFMCKCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS----------------------------------------------- ---------------------------LRSERNNMVNMANGPHHPNPPPENVQLVNQ-YVSK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVISSEHVIERETETS- ---FSTSHYTSTTHHSTTVTQTPS---------------------------HSWSNGQSESMISES------HSVIVTSS VENSRHTSPTG-PRGRLNGIGGPRDCS-YLRHA----RDTPDSYRDSPHSERYVSAMTTPARMSPVEFQTP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------ISPKSPCLERSPPESSLAVSVPSVAV---------SPFIEEERPLLLVSPPRLR DKRYDLYYH-------------HHHYNQQYN------------------------------------------------- ----------------------------------------------------------------SYHHNPAHDSSSLPPS PLRIVEDE------------------------------------------------------------------------ EYETTQEYEP---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------S QEPAKKLVNS----RRAKRTKPNGHISNRLELDTDTSSESSTSE------------------------------------ -----SETEDERIGEETPFLSIQNPLAASLESASLYRHAD---------------------------------------- -----------------------------SRTNPTSRFSTQEELQARLSSVIANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Danio_rerio_NRG1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------MAILPGRSSSLTVSVLYGAAV CLSLWTRVVRCGSFACSPPGASVQELARRSGVVFEGKLQEEERAERNWTETPMNASRQVRVRVQQVWQLKAGGLIKDSVV SLVWFEGGRCF--------------------------------------------------------------------- -------------------------------------------------------------------------QLNTGIR YMFFIEPTNDTSVFTAVFPP-VETKRTVRKDVSQVLCQDCAEPKLKNLRSVTVEDGKKTVLKCEILAGNPAPNVKWYKNG KELTGKNKPKSIKIKKKKQGKISELLIRKSTEGDAGLYTC-----------EAVNSLGKTNTTANLFIINTATSTTPSAK TSSHVTPCNESEKEY-------CVNHGK----------------------------------CFTLEVTPGNIRRLCRCP NEFTGDRCQHYV---MASFYKHL-------------------------------------GIEFMEAEELYQKRVLTITG ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS----------------------------------------------- ---------------------------LR-ERN---AAAKGPQHPHPPPENLQLVNH-YMPT------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NPVP-AHMTDKEAETS- ---LSTNEFTSPTHPSTAITHSSS---------------------------QCWSNGKAESVVSDS------HAVLMKPS AENCQHGTPSH--RGRLNATGGVHQLNDYLKNS----REAQGSNRDSPYSERYVSAMTTPTRLSPVGLLSP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------VTPSSPPSEMSAPLSSLATSVPSMLT---------SPSGEEERPLLFRTPPILR DKSASTQ---------------GRKSGHNLRN------------------------------------------------ ----------------------------------------------------------------SAHYNHGLDIPSPPPS PLHIEEEI------------------------------------------------------------------------ --DCLEQYKS---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------T SVPSSAPHSP-----SAARTQPSGQAAPEQAVSG-SNSESSSSE------------------------------------ -----SETEDERVGEDTPFLGLQNPLAAG--SLVLDGLEG---------------------------------------- -----------------------------SRTNPALHLSPQHELQNRLTAVMANQDPIAV-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Gasterosteus_aculeatus_NRG1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------DGEHLGALGIVAVPGSCCVCMEMEQINNCLHSEKICILPILACLLS--LALCTA GLKWVFVDKIF--------------------------------------------------------------------- -------------------------------------------------------------------------QYEP-PT HLDPKRIGQDPIIISVSPTLGLTMSIPHSSPSFVSLTTAITPGRPDDLSAALIPASLEPTAPVSTHTAPPSSAADSPVPP PGVRPFLFLP--------------------------------------------FSLTIPRILTVRLSSAAATSSTTTAK TSSHVTRCSHRQRNY-------CVNGGE----------------------------------CFTLEITPGSTKFLCRCP NEFTGDRCQNYV---MASFYKHL-------------------------------------GIEYMEAEELYQKRILTITG ICIALLVVGIMCVVAYCKTKKQRRKLHDHLKQS----------------------------------------------- ---------------------------LRKKRTKNTNTGIGPNDSNLPLQDLQLIDH-CNET------------------ -------------------------------------------------------------------------------- ------------------------------------------------------------------TLQHGGEGNTETN- ---LSTSKKALMVHGPTAFSDIPI---------------------------QLFRHRHLIRALQQSS-----HDELILWD KPCRSTSKSPPKPTQGMNHECG----QSQLELA----RVWGSGFRLLSLKEKCVPAMTTKTQVCLVSQTSP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------ATPGSPPSEMSAPLSSLAISVPSLAL---------SPSGEEERPLLLSNTCQPC KSMS---------------------RDEQKRT------------------------------------------------ ----------------------------------------------------------------SAHYNHGHVTHSLPPS PLFTME-------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Drosophila_melanogaster_NRG1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------MRAQDLL LLATALIGAYLP-------------LTAACSSR----------------------------------------------- -----------------------------AIAKPRPTAAPILPPDNVEISTTPRPN------------------------ -------------------------------------------------------------------------------- ----------------------------------------------------------------VTFPIFACPPTYVAWY -------CLNDGTCFTVKIHNEILYN------------------------------------------------------ CECALGFMGPRCEYKEIDGSYLPTRNRVMLE------KAS--IVSGATLALLFMAMCCVVLYLRHEKLQKQK-------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------LHDSTTTTTTDGGCQNEGMDEVDG--------------LRPLRPVRRPFG-- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------PCR ILSLEEAHLQ---------------------------------------------------------------------- -----AKASN---------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------RPRHCNELLR------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Homo_sapiens_NRG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------MRQVCCSALPPPPLEKGRCSSYSDSSS---------SSSERSSSSSS SSS---ESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSP SLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVG------SCVPLE RNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQTGQ-VGEKQSLKCEAAAGNP--QP SYRWFKDGKEL--------------------------------------------------------------------- -------------------------------------------------------------------------NRSRDIR IKYGNG---------------RKNSRLQFNKVKVEDAGEYVCEAENILGK--DTVRGRLYVNS----------------- -------------------------------------------------------------------------VSTTLSS WSGHARKCNETAKSY-------CVNGGV----------------------------------CYYIEG---INQLSCKCP NGFFGQRCLEKLPLRLYMPDPKQ----------------------------------KHLGFELKEAEELYQKRVLTITG ICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQN----------------------------------------------- ----------------------------MCPAHQNRSLANGPSHPRLDPEEIQMAD--YISK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVPATDHVIRRETETT- ---FSGSHSCSPSHHCSTATPTSS----------------------HRHESHTWSLERSESLTSDS------QSGIMLSS VGTSKCNSPACVEARARRAAAYNLE--ERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------LATQVPTFEITSPNSAHAVSLPPAAP--------ISYRLAEQQPLLRHPAPPGP GPGPGPGPGP-----GADMQRSYDSYYYPAAGPGP--------------------------------------------- ---------------------------------------------------------------RRGTCALGGSLGSLPAS PFRIPEDD------------------------------------------------------------------------ EYETTQECAP----PPP--------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------PRPRA RGASRRTSA---GPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGS------------------------------ASA SDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPA----------------------------------------- ------------------------ADSRTYYSLD-SHSTRASSRHSRGPPPRAKQDSAPL-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Pan_troglodytes_NRG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------MRQVCCSALPPPPLEKGRCSSYSDSSS---------SSSERSSSSSS SSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSP SLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVG------SCAPLE RNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQTGQ-VGEKQSLKCEAAAGNP--QP SYRWFKDGKEL--------------------------------------------------------------------- -------------------------------------------------------------------------NRSRDIR IKYGNG---------------RKNSRLQFNKVKVEDAGEYVCEAENILGK--DTVRGRLYVNS----------------- -------------------------------------------------------------------------VSTTLSS WSGHARKCNETAKSY-------CVNGGV----------------------------------CYYIEG---INQLSCKCP NGFFGQRCLEKLPLRLYMPDPKQ----------------------------------KHLGFELKEAEELYQKRVLTITG ICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQN----------------------------------------------- ----------------------------MCPAHQNRSLANGPSHPRLDPEEIQMAD--YISK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVPATDHVIRRETETT- ---FSGSHSCSPSHHCSTATPTSS----------------------HRHESHTWSLEHSESLTSDS------QSGIMLSS VGTSKCNSPACVEARARRAAAYNLE--ERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------LATQVPTFEITSPNSAHAVSLPPAAP--------ISYRLAEQQPLLRHPAPPGP GPGPGPGPG-------ADMQRSYDSYYYPAAGPGP--------------------------------------------- ---------------------------------------------------------------RRGTCALGGSLGSLPAS PFRIPEDD------------------------------------------------------------------------ EYETTQECAP----PPP--------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------PRPRA RGASRRTSA---GPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGS------------------------------ASA SDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPA----------------------------------------- ------------------------ADSRTYYSLD-SHSTRASSRHSRGPPPRAKQDSAPL-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Mus_musculus_NRG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------MRQVCCSALPPP-LEKARCSSYSYSYSDSSSSTTSSSRSSSSSSSRN SSSSNSSSSESSGSNSGSSSIFRPAAPPEPRPQPQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSP SLKSVQDQAYKAPVVVEGKVQGLAPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVG------SCAPLE RNQRYIFFLEPTEQPLVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMKSQTGE-VGEKQSLKCEAAAGNP--QP SYRWFKDGKEL--------------------------------------------------------------------- -------------------------------------------------------------------------NRSRDIR IKYGNG---------------RKNSRLQFNKVRVEDAGEYVCEAENILGK--DTVRGRLHVNS----------------- -------------------------------------------------------------------------VSTTLSS WSGHARKCNETAKSY-------CVNGGV----------------------------------CYYIEG---INQLSCKCP NGFFGQRCLEKLPLRLYMPDPKQ----------------------------------K--------AEELYQKRVLTITG ICVALLVVGIVCVVAYCKTKKQRRQMHHHLRQN----------------------------------------------- ----------------------------MCPAHQNRSLANGPSHPRLDPEEIQMAD--YISK------------------ -------------------------------------------------------------------------------- ---------------------------------------------------------------NVPATDHVIRREAETT- ---FSGSHSCSPSHHCSTATPTSS----------------------HRHESHTWSLERSESLTSDS------QSGIMLSS VGTSKCNSPACVEARARRAAAYSQE--ERRRAAMPPYHDSIDSLRDSPHSERYVSALTTPARLSPVDFHYS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------LATQVPTFEITSPNSAHAVSLPPAAP--------ISYRLAEQQPLLRHPAPPGP GPGSGPG---------ADMQRSYDSYYYPAAGPGP--------------------------------------------- ---------------------------------------------------------------RRSACALGGSLGSLPAS PFRIPEDD------------------------------------------------------------------------ EYETTQECAP----PPP--------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------PRPRT RGASRRTSA---GPRRWRRSRLNGLAAQRARAARDSLSLSSGSGCGS------------------------------ASA SDDDADDADGALAAESTPFLGLRAAHDALRSDSPPLCPA----------------------------------------- ------------------------ADSRTYYSLD-SHSTRASSRHSRGPPTRAKQDSGPL-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --- >Rattus_norvegicus_NRG2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------MLLFGVSLACYSP SLKSVQDQAYKAPVVVEGKVQGLAPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVG------SCAPLE RNQRYIFFLEPTEQPLVFKTAFAPVDPNGKNIKKEVGKILCTDCATRPKLKKMKSQTGE-VGEKQSLKCEAAAGNP--QP