>Homo_sapiens_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF KVD-NDEN----------------EHQLSLR------------------------------------------------- ---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT------- ---------------------------------------------------VSLGGFEITPPVVLRLK------------ ------CGSGP--------------------------------------------------------------------- -------------------------------------------------------VHISGQHLVAVEED----AESEDEE EEDVKLLSISGKRSAPGGGSKVPQ-KKVKLAADE-DDDD-DDEEDDDEDDDDDDFDD----------E---EAEEKAP-- -VKKSIRDTPAKNAQKSNQNGKDSKPSS---TPRSKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE AKFINYVKNCFRMTDQEAIQDLWQWRKSL--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Macaca_mulatta_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF KVD-NDEN----------------EHQLSLR------------------------------------------------- ---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT------- ---------------------------------------------------VSLGGFEITPPVVLRLK------------ ------CGSGP--------------------------------------------------------------------- -------------------------------------------------------VHISGQHLVAVEED----AESEDEE EEDVKLLSISGKRSAPGGGSKVPQ-KKVKLADLK-YDCI-DDELDDNENAKRCRFVD----------Y---SMQEKAP-- -VKKSIRDTPAKNAQKSNQNGKDSKPSS---TPTSYGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE AKFINYVKNCFRMTDQEAIQDLWQWRKSL--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Mus_musculus_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF KVD-NDEN----------------EHQLSLR------------------------------------------------- ---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT------- ---------------------------------------------------VSLGGFEITPPVVLRLK------------ ------CGSGP--------------------------------------------------------------------- -------------------------------------------------------VHISGQHLVAVEED----AESEDED EEDVKLLGMSGKRSAPGGGNKVPQ-KKVKLDEDD---EDDDEDDEDDEDDDDDDFDE----------E---ETEEKVP-- -VKKSVRDTPAKNAQKSNQNGKDLKPS----TPRSKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE AKFINYVKNCFRMTDQEAIQDLWQWRKSL--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Rattus_norvegicus_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF KVD-NDEN----------------EHQLSLR------------------------------------------------- ---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT------- ---------------------------------------------------VSLGGFEITPPVVLRLK------------ ------CGSGP--------------------------------------------------------------------- -------------------------------------------------------VHISGQHLVAVEED----AESEDED EEDVKLLGMSGKRSAPGGGNKVPQ-KKVKLDEDD---DEDDEDDEDDEDDDDDDFDE----------E---ETEEKVP-- -VKKSVRDTPAKNAQKSNQNGKDLKPS----TPRSKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE AKFINYVKNCFRMTDQEAIQDLWQWRKSL--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Canis_familiaris_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF KVD-NDEN----------------EHQLSLR------------------------------------------------- ---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT------- ---------------------------------------------------VSLGGFEITPPVVLRLK------------ ------CGSGP--------------------------------------------------------------------- -------------------------------------------------------VHISGQHLVAVEED----AESEDEE EEDVKLLSISGKRSAPGSGSKVPQ-KKVKLAADE-DDDDDDDDDDDDEDDDDDDFDD----------E---EAEEKAP-- -VKKSIRDTPAKNAQKSNQNGKDSKPS----TPRTKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE AKFINYVKNCFRMTDQEAIQDLWQWRKSL--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Bos_taurus_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADR-DYHF KVD-NDEN----------------EHQLSLR------------------------------------------------- ---------TVSLGAGAKDELHVVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT------- ---------------------------------------------------VSLGGFEITPPVVLRLK------------ ------CGSGP--------------------------------------------------------------------- -------------------------------------------------------VHISGQHLVAVEED----AESEEEE EEEVKLLSISGKRSAPGSGSKVPQ-KKVKLAADEDEDDDDDDDDDDDEDDDDDDFD-----------E---EVEEKAP-- -VKKSVRDTPAKNAQKSNQNGKDSKPS----TPRSKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE AKFINYVKNCFRMTDQEAIQDLWQWRKSL--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Equus_caballus_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF KVD-NDEN----------------EHQLSLR------------------------------------------------- ---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT------- ---------------------------------------------------VSLGGFEITPPVVLRLK------------ ------CGSGP--------------------------------------------------------------------- -------------------------------------------------------VHISGQHLVAVEED----AESEDEE EEDVKLLSISGKRSAPGSGSKVPQ-KKVKLAADE-DDDDEDDDEDDDEDDDDDDFDE----------E---EAEEKAP-- -VKKSIRDTPAKNAQKSNQNGKDSKPS----TPRSKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE AKFINYVKNCFRMTDQEAIQDLWQWRKSL--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Loxodonta_africana_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF KVD-NDEN----------------EHQLSLR------------------------------------------------- ---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT------- ---------------------------------------------------VSLGGFEITPPVVLRLK------------ ------CGSGP--------------------------------------------------------------------- -------------------------------------------------------VHISGQHLVAVEED----AESDDEE DEDVKLLSMSGKRSAPAAGNKVPQ-KKVKLAADE-DDDEEDDDDDDDEDDDDDDFDD----------E---ETEEKVP-- -VKKSVRDTPAKNAQKSNQNGKDSKPS----TPRSKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE AKFINYVKNCFRMTDQEAIQDLWQWRKSL--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Monodelphis_domestica_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MEDSMEMD----------MSPLRPQNFLFG-------------------------------------CELKADK-DYHF KVD-NDEN----------------EHQLSLR------------------------------------------------- ---------TVSLGAGAKDELHIVEAEAL-----------------------NYEGNPIKVTLASLKMSVQPT------- ---------------------------------------------------VSLGGFEITPPVVLRLK------------ ------CGSGP--------------------------------------------------------------------- -------------------------------------------------------VHVSGQHLVALEED----AESDDEE EDDMKLLNMSGKRSAPGVGSKVPQ-KKVKLSEED---EEDDEEDDDDEDDDDDDFED----------E---ESEEKTPP- -VKKSVRDTAAKNAQKSNQNGKDSKPS----TPKAKGQDS-FKKQ-DKTPKTPKGPTSLEDIKAKMQASIEKGGSLPKVE GKFINYVKNCFRMSDQEL-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Ornithorhynchus_anatinus_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------HYLAG-------------------------------------CELKADK-DYHF KVD-NDEN----------------EHQLSLR------------------------------------------------- ---------TVSLGAGAKDELHVIEAEAL-----------------------NYEGSPIKVTLASLKMSVQPT------- ---------------------------------------------------VSLGGFEITPPVVLRLK------------ ------CGSGP--------------------------------------------------------------------- -------------------------------------------------------VHVSGQHLVALEED----AVSDDDE EEEVKLGNLSGKRPAPGVVPKVPQ-KKAKLAELAVTDGAHHQPNDTLDEDEDDDFE----------------EEEKTP-- -AKKSARDTPAKNAQKSNQNGKDSKPS----TPKSKGSES-FKKQQEKSPRTPKGPLTVDDVKAKMQATMEKGGALPKVE GKFINYVKNCFRMSDQEAIQDLWLWRKSL--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Gallus_gallus_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------LAG-------------------------------------CELKAEK-EYQF KVD-DEEN----------------EHQLSLR------------------------------------------------- ---------TVTLGAGAKDELHVVEAEAL-----------------------DYEGNPTKVVLASLKMSVQPT------- ---------------------------------------------------VSLGGFEITPPVVLRLK------------ ------CGSGP--------------------------------------------------------------------- -------------------------------------------------------VYVSGQHLVALEEE----PESEDE- EEDTKIGNASTKRPASGGGAKTPQ-KKPKLSEDDEDDDEDEDDDEDDEDDLDD--------------D---EEEIKTP-- -MKKPAREPAGKNMQKAKQNGKDSKPST--PASKTKTPDS--KKDKSLTPKTPKVPLSLEEIKAKMQASVDKGCSLPKLE PKFANYVKNCFRTEDQKVIQALWQWRQTL--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Anolis_carolinensis_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MEDTDMDS----------MGSLRPQTFLFG-------------------------------------CELKGDK-PFHF KVN-DEEN----------------EHQLSLR------------------------------------------------- ---------TVSLGAGAKDDLHVVEAEAL-----------------------DYEGNQITVTLASLKMSVQPT------- ---------------------------------------------------VSLGGFEITPPVTLRLK------------ ------CGSGP--------------------------------------------------------------------- -------------------------------------------------------VYVSGQHLVALEEE----PESEDE- EDD-KVQHNMAKRPAGVTLAKVPQ-KKAKLTEDDEDDDEDDEDDDEDDDDEEDDDDDME-------ED---EEEEKTP-- -VKKPARDLAVKKTQKSNQNGKDSKPTT--P--KQKTPET-HKEKKPQTPKTPKT-FTLEEIKAKMQAVVQKGTALPKAE AKFANYVKNCYRTEDQKVIQALWQWRQTL--------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Xenopus_tropicalis_NPM1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MEDSMDMDS---------IAPLRPQNFLFG-------------------------------------CELKADKREYSF KVE-DDEN----------------EHQLSLR------------------------------------------------- ---------TVSVGASAKDELHVVEAEGI-----------------------NYEGKTIKITLASLKPSVQPT------- ---------------------------------------------------VSLGGFEITPPVILRLK------------ ------SGSGP--------------------------------------------------------------------- -------------------------------------------------------VYVSGQHLVALEDL----ESTDDED EEHDVPSPKNAKRTASDAASKVPR-KKTRLEEED---EADSDEYVYKKNKNNEDFQIN-------------IYYNKRP-- -VKKTDLPTKPKAAQKLNHNGKASELPTPLKTPKTPEQKG-KQDTKPQTPKTPKTPLSFDEIKAKMQTSLEKGTVLPKVE VKFANYVKNCFRTENQKVIQDLFKWRQSLKDSK----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Danio_rerio_NPM1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------MSINTPELRLTG PVRAKMEDNI---------KDLSRPQMYLFG-------------------------------------CSLKADKKEHKV DLD-DDEA----------------EHQLSLK------------------------------------------------- ---------SVCLGAEAEDKFHTVEMEGL-----------------------TYDGKTTKITLAVLKPSVLPS------- ---------------------------------------------------LSLGGFEVTPPVSFRLQ------------ ------SGGGP--------------------------------------------------------------------- -------------------------------------------------------VYISGQHFVSVKES-------DDED EEEEENNTSPVKRPSNMTLAKVPQ-KKLKMDSDEDEDSDDDDDDDDDDDDDEEEDDDKQ-------EKPAVKSPVKSTQK TPEK-KKSADKQNGSPDKKAGTSGKPQ-------TQTPQKVKDKSAAGPSGKTPSIPSLSEVKSKLTSAAKEGKPFPKTE QKFENFARSSFKISDKQVIKDLWNFVQSLKK------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Danio_rerio_NPM1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MDLE------------QMGPQTFLYG-------------------------------------CELKAGK-DITF NPE-DDDY----------------DHQLSVR------------------------------------------------- ---------MACVDPSTKDELNVVEIEGQ-----------------------DSEGQKVKAVLATLKPSTLPS------- ---------------------------------------------------VCLGGFEITPPVVFRLR------------ ------TGSGP--------------------------------------------------------------------- -------------------------------------------------------VHISGQHLVIMGGDQSFDEEEE--E EEEEETVMTSKKRPALS--TPKPS-KKMKMDEED---DDDDDEDDDDEDDDE--------------ED---ESEEESP-- --VK-EKKAPAK-PKTPTQNGKGPKPST---PAK---QTPQ-KGKKEQTPKTPQTPRTLADIKSKMMESVAKGVSLPKVQ LKFENYVNNCFKGTDPKVVEELWKWRQTVK-------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Takifugu_rubripes_NPM1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------------TVCGSV ATTVKMEDDF---------SDLSRPQIYLFG-------------------------------------CTLKSDKREFKI DVE-DDDT----------------EQQLSLK------------------------------------------------- ---------AVCVGAEAEDNFHMVEIEGL-----------------------TYDGKSTKVPLAVLKPSIMPS------- ---------------------------------------------------MSLGGFEIMPPVTFRLQ------------ ------AGSGP--------------------------------------------------------------------- -------------------------------------------------------VHISGQHFIRVKDG-------EEEE EEEE-NNTSPVKRPLSLVSGKKPPSKKLKMDSDDEDDSEEDDDDYSDEDDDSDG-DVKP-------QK---KTLKKIPDS SAKKTSKTPVKQNGPAEKPSGSSSKPQ-------MKTPAPGKDKAQAGPS-KSSSLP---EIKNKLSTAAKEGKPLPKTE QKFENFVKSSFKITDKKVVKDLWAFVQSLKI------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------- >Tetraodon_nigroviridis_NPM1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----MEDDF---------SDLSRPQIYLFG-------------------------------------CTLKSDKREFKI DAD-DDDT----------------EQQLSLK------------------------------------------------- ---------AMCVGPEAEDKFHMVEIEGL-----------------------TYDGKSTKVPLAALKPSIMPS------- ---------------------------------------------------MSLGGFEIMPPVTFRLQ------------ ------AGSGP--------------------------------------------------------------------- -------------------------------------------------------VHISGQHFVRVKDA-------QEEE E----NNTSPVKRPLSLS-VKKPTSKKLKMD----EDSDEEDNEDDDEDDESDE-DVKP-------QK---KELKKIPDF SAKKTSKTPVKENGPTEKSSGLPSKPQT----KVSQTPAAEKDKAQAGPS-KSPSLP---EIKNKLSTAAKEGKPLPKTE QKFENFVKSSFKITDKKVVKDLWTFVQSLKIEK----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------