>Homo_sapiens_NKX2-1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M SMSPK-------------------------------------------------------------------HTTPFSVS DILSPLEESYKKVG---MEGGG----LGAPLA------------------------------------------------ ----------------------------------AYRQGQAAPPTAAMQQHAVG-------------HHG--------AV TAAYHMT---AAGVPQLSH------------------------------------------------------------- ----------------------------------------------SAVGGYCNGNLG---NMSELPPYQDTMRNSASGP G----------WYGANP------DPRFPAISRFMGPA--------------SGMNMSG---------------------- ----------------------------------------------MG-GLGSLGDVSKNMAP-LP-------------- -------------------------------------SAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL T---PTQVKIWFQNHRYKMKRQAKDKAA---------------------QQQLQQ-----DSGGGGGGG-GTGCPQQQQ- AQQQSPRRVAVPV-------------------LVKDGKPCQAG------------------------------------- --------------------------APAPGAASLQGHAQQQAQ-HQAQAAQAAA--------AAISVGSGGAGLGAHPG HQPGSAGQ---------------SPDLAHHA---------------ASPAALQGQVSSLSHLNSSGS-DYG-TMSCST-- -------LLYGRTW------------------------------------------------------------------ ---------------------------- >Mus_musculus_NKX2-1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M SMSPK-------------------------------------------------------------------HTTPFSVS DILSPLEESYKKVG---MEGGG----LGAPLA------------------------------------------------ ----------------------------------AYRQGQAAPPAAAMQQHAVG-------------HHG--------AV TAAYHMT---AAGVPQLSH------------------------------------------------------------- ----------------------------------------------SAVGGYCNGNLG---NMSELPPYQDTMRNSASGP G----------WYGANP------DPRFPAISRFMGPA--------------SGMNMSG---------------------- ----------------------------------------------MG-GLGSLGDVSKNMAP-LP-------------- -------------------------------------SAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL T---PTQVKIWFQNHRYKMKRQAKDKAA---------------------QQQLQQ-----DSGGGGGGGGGAGCPQQQQ- AQQQSPRRVAVPV-------------------LVKDGKPCQAG------------------------------------- --------------------------APAPGAASLQSHAQQQAQ-QQAQAAQAAA--------AAISVGSGGAGLGAHPG HQPGSAGQ---------------SPDLAHHA---------------ASPAGLQGQVSSLSHLNSSGS-DYG-AMSCST-- -------LLYGRTW------------------------------------------------------------------ ---------------------------- >Takifugu_rubripes_NKX2-1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------TM SMSPK-------------------------------------------------------------------HTTPFSVS DILSPLEESYKKVS---MENNN----LGAPLT------------------------------------------------ ----------------------------------SYRQPQVSQA--AMQQHHMG-------------HNG--------TV SAAYHMT---ATGVSQLSH------------------------------------------------------------- ----------------------------------------------TAMGGYCNGNLG---NMGELPSYQDGMRGSTTAT G----------WYGANP------DPRFSTISRFMGSS--------------SGMNMGS---------------------- ----------------------------------------------MG-SLTSLADVGKGMGS-LS-------------- -------------------------------------STPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL T---PTQVKIWFQNHRYKMKRQAKDKAS---------------------QQQMQQ-----DSGSCQ-------------- QQQ-SPRRVAVPV-------------------LVKDGKPCQGSG------------------------------------ ---------------------------HTPTSSS-QNHHQQGGN-------------------VMIMSNNTSG-LGQHQN QQVGSTGH---------------SPDLAPHS---------------SSPTSLQSQVAGLSHLNSPGA-EYGSALQCSA-- -------LLYGRTW------------------------------------------------------------------ ---------------------------- >Branchiostoma_floridae_NKX2-1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------ME SISPK-------------------------------------------------------------------QTTPFSVT DILSPLEEMYKKPMDGTMTGGYAG-TMNAAAAGM---------------------------------------------- -------------------------------GAGGYRQQVTQP----LQHQSMN-----------------------VPV SNPYMHVP------TQLSH------------------------------------------------------------- ----------------------------------------------GMANPYCNGNVS------DLPHYNEHVRNT--AS S----------WYGANP------DPRFS-FPRLMGGH--------------SG-GMGN---------------------- ----------------------------------------------MGMSLGTIEG-PKPILP----------------- -------------------------------------TTQRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLAQLINL T---PTQVKIWFQNHRYKCKRQDKERQKSSTDQPSQQQQQ---QQQPQQQQQQQQQQQVSQHQAGQVQG---QAGQQNMC AAGNSPRRVAVPV-------------------LVKDGKPCGNTP------------------------------------ --------------------------STTPVTGVTANMS----------------------------------------- ----AATP---------------QLNPQSQANI-------------IGTTVATVNVNGLNSHMSSGNYANNTMSSCSSSQ -----YLLQQGRAW------------------------------------------------------------------ ---------------------------- >Strongylocentrotus_purpuratus_NKX2-1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M SYSPK-------------------------------------------------------------------QTTSFSVA DILTPLEESFRRSML-DSPGSAF--PSVFSAAPS---------------------------------------------- -------------------------------MQSAYRSPQHSAH-QGMQVSPMN-------------MAS--------AN NPYAHMH------VPQLSH------------------------------------------------------------- --------------------------------------------------NYCNGSVG------ELSQHYSDHRPSAASW Y-----------HGASS------DPRFT-ISRLMNHS--------------STMNMNMNMN------------------- ----------------------------------------------MNMNMNMNMSTLSAVGSGDLGKP----------- -----------------------------------LLPSHRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLANLINL T---PTQVKIWFQNHRYKMKRQTKEKNM---------------------QD---------NNTICHQ------------- ----SPRRVAVPV-------------------LVKDGKPCNGSSGG---------GGNTGGDLTDDD------------- ----------DRSLSGQVEGVSDQGVVGGPQQQQPQQQQQQGNVTQSMSSQQTAANHHASMKASPVEPSSCGIPISIPSS DSGIGLSP---------------VSVHAHHQHP-------------MSQASLHHQASAMHSLYSPSAGAAGMTHNGAVNN MSATAPFLLHGRTW------------------------------------------------------------------ ---------------------------- >Hydra_magnipapillata_NKX2-1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M DFSILP------------------------------------------------------------------VNSSFLVD DILRRKHYENKIHQSNFSQFSVLSDEISIKTR------------------------------------------------ ------------------------LSAFPIYNKGMHKNKELVNKSFQMNDKNITETERDFN-----------------KS SISFDMTSNVEYSFGDKRMN------------------------------------------------------------ -------------------------------------------------------NRHSFQGLSCMVAEAEMYARGKRED N------------SSDENSPKCESPSLTAKTEYHNAS------------------------------------------- --------------------------------------------------ADAMHVTSESLIQQNLLN------------ ------------------------------------IKSSRKKPRILFSQSQVMELEKKFKDQKYLSASERDQIANKLNL T---PTQVKIWFQNKRYKCKKQTIESRTRPPPYEWLH------------------------------------------- ---FQHRNVPVLVQN-----------------NQVSSDVCLP-------------------------------------- ----------------------------------------------------------------------------YCNR PTYLPSNS---------------PVDMNYPPFYP-------------DPYNGHNHHYSNSYNTPSQTSTYPNSWPFYK-- -------------------------------------------------------------------------------- ---------------------------- >Homo_sapiens_NKX2-2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MSLTN------------------------------------------------------------------TKTGFSVK DILDLPDTN---DEEGSVAEGPEEEN------------------------------------------------------ ---------------------------------EGPE---PAKRAGPLGQGALD-------------------AVQSLPL KNPFYDSSDNPYTRWLAST------------------------------------------------------------- ----------------------------------------------------EGLQYS-LHGLAAGAPPQDSSSKSPEPS --------------AD------ESPDNDKETPG----------------------------------------------- ----------------------------------------------------------GGGDA----------------- --------------------------------------GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRL T---PTQVKIWFQNHRYKMKRARAEKGMEV-------------------------------------------------- TPLPSPRRVAVPV-------------------LVRDGKPCH--------------------------------------- ----------------------------------------------------------------------------ALKA QDLAAATF---------------QAGIPFSA---------------YSAQSLQ-HMQYNAQYSSAST---PQYPTAHP-- -------LVQAQQWT----------W------------------------------------------------------ ---------------------------- >Mus_musculus_NKX2-2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MSLTN------------------------------------------------------------------TKTGFSVK DILDLPDTN---DEDGSVAEGPEEES------------------------------------------------------ ---------------------------------EGPE---PAKRAGPLGQGALD-------------------AVQSLPL KSPFYDSSDNPYTRWLAST------------------------------------------------------------- ----------------------------------------------------EGLQYS-LHGLAASAPPQDSSSKSPEPS --------------AD------ESPDNDKETQG----------------------------------------------- ----------------------------------------------------------GGGDA----------------- --------------------------------------GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRL T---PTQVKIWFQNHRYKMKRARAEKGMEV-------------------------------------------------- TPLPSPRRVAVPV-------------------LVRDGKPCH--------------------------------------- ----------------------------------------------------------------------------ALKA QDLAAATF---------------QAGIPFSA---------------YSAQSLQ-HMQYNAQYSSAST---PQYPTAHP-- -------LVQAQQWT----------W------------------------------------------------------ ---------------------------- >Danio_rerio_NKX2-2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------MLQ NMSLTN------------------------------------------------------------------TKTGFSVK DILDLPDTN---DEEGS-ITGTEEDT------------------------------------------------------ ---------------------------------EGSE---ATKTPGVLVQSPLE-------------------NVQNLPL KNPFYDNSDNPYTRWLATT------------------------------------------------------------- ----------------------------------------------------DSIQYS-LHGLSAN--SQDTSAKSPEPS --------------AD------ESPDNDKETSS----------------------------------------------- ---------------------------------------------------------NG-SDS----------------- --------------------------------------GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRL T---PTQVKIWFQNHRYKMKRARAEKGMEV-------------------------------------------------- THLPSPRRVAVPV-------------------LVRDGKPCH--------------------------------------- ----------------------------------------------------------------------------TLKA QDLAA-TF---------------QAGIPFSA---------------YSAQSLQ-HMQYNAHYSAATT---PQFPTAHH-- -------LVQTQQWT----------W------------------------------------------------------ ---------------------------- >Takifugu_rubripes_NKX2-2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MSLTN------------------------------------------------------------------TKTGFSVK DILDLPDTN---DEEGS-ITGAEEDT------------------------------------------------------ ---------------------------------EGSE-TSTTKTAGVLVQSPLE-------------------NVQNLPL KNPFYDSSDNPYTRWLATT------------------------------------------------------------- ----------------------------------------------------DSIQYS-LHGLSAS--SQD-SAKSPEPS --------------ADD-----ESPDNDKETSS----------------------------------------------- ---------------------------------------------------------SGGSDS----------------- --------------------------------------GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRL T---PTQVKIWFQNHRYKMKRARAEKGMEV-------------------------------------------------- THLPSPRRVAVPV-------------------LVRDGKPCH--------------------------------------- ----------------------------------------------------------------------------TLKA QDLAA-TF---------------QAGIPFSA---------------YSAQSLH-NMQYNAPYGAAAT---PQFPTAHH-- -------LVQTQQWT----------CAADINGEGSDGRSGGVRAQILATSDHKMAAEVRAWRHAAF-------------- ---------------------------- >Branchiostoma_floridae_NKX2-2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------MDP KMSLN-------------------------------------------------------------------SKTSFTVK DILDMPEAKRQSPDTGSSVPGTMASA------------------------------------------------------ ---------------------------------TSVG---SASHTGQLSQG-----------------------SSALP- --PYYDASENPYMRWLGSA------------------------------------------------------------- ----------------------------------------------------EEMQYNSLTHIASSQSSPGSSTGAETSS TADAKNTADKVDFDDDE-----EDEDDDGSTTGSANDGT----------------------------------------- ---------------------------------------------------GNSSSPGGQGDQ----------------- --------------------------------------PKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLARLIRL T---PTQVKIWFQNHRYKCKRAQKEGHMDTGL------------------------------------------------ NPLPSPRRVAVPV-------------------LVRDGKPCQPT------------------------------------- --------------------------------------------------------------------------VTSCNG YMKPVDSM---------------LSGMNMNMH--------------HSAMQTMQHMQQQMQPLQTMPYQYPIMPNSSL-- -------STSYGTWA----------W------------------------------------------------------ ---------------------------- >Nematostella_vectensis_NKX2-2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------GNEP----------------- --------------------------------------PKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREQLARIINL T---PTQVKIWFQNHRYKFKKQNYEKGPLSEP--------------------------------------PP-------- --LFTPRTVPVPV-------------------LVRDGQPCH--------------------------------------- ---------------------------------------------------------------------------GAS-- --------------------------------------------------MNNFAYHHAADFLHYPP-----VSTSYM-- -------PAHPYWT-----------W------------------------------------------------------ ---------------------------- >Homo_sapiens_NKX2-3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MM LPSPVTS-------------------------------------------------------------------TPFSVK DILNLEQ------------------------------------------------------------------------- ----------------QHQ--------------HFHGAHLQADLEHHFHSAP--------------------------CM LAAAEGTQFSDG-------------------------------------------------------------------- -------------------------------------------------------GEEDEEDEGEKLSYLNSLAAAD--- ------------GHGDSGLCPQGYVHTVLRDSCSE--------------------------------------------- ---------------------------------PKEHEEEPEVVRDR---SQKSCQLKKSLETAGDCK------------ ---------------------------AAEESERPKPRSRR-KPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKL T---STQVKIWFQNRRYKCKRQRQDKSLELGAHAP--------------------------------------------- --PPPPRRVAVPV-------------------LVRDGKPCVTPSA-----------QAYGAPYS-----VGASAYSYNSF PAYGYGNSAAAAAAAAAAAAAAAAYSSSYGCAYPA---------------------------------GGGGGGGGTSAA TTAMQPAC---------------SAAGGGPFVN------------VSNLGGFGSGGSAQPLHQGTA---AGAACAQGT-- -------LQGIRAW------------------------------------------------------------------ ---------------------------- >Mus_musculus_NKX2-3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MM LPSPVTS-------------------------------------------------------------------TPFSVK DILNLEQ------------------------------------------------------------------------- ----------------QRH---------------FHGAHLQAELEQHFHSAP--------------------------CM LATAEGTQFSDA-------------------------------------------------------------------- -------------------------------------------------------GEEDEEEEGEKLSYLNSLAAAE--- ------------GHGDSGLCPQSYVHTVLRDACSG--------------------------------------------- ---------------------------------PKEQEEE--VVSER---SQKSCQLKKSLEAAGDCK------------ ---------------------------TSEDGERPKPRSRR-KPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKL T---STQVKIWFQNRRYKCKRQRQDKSLELGTHAP--------------------------------------------- --PPPPRRVAVPV-------------------LVRDGKPCVTPSA-----------QTYGSPYG-----VGAGAYSYNSF PAYGYGNSAAAAAAAAAAAAAAAAYSGSYGCAYPTG--------------------------------GGGGGGGTASAA TTAMQPAC---------------SATGGGSFVN------------VSNLGGFGSGGGAQPLHQGAA---AGSACTQGT-- -------LQGIRAW------------------------------------------------------------------ ---------------------------- >Takifugu_rubripes_NKX2-3_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------VA MRDPRTS-------------------------------------------------------------------TRHLLL NILKLEQQQQ---------------------------------------------------------------------- ----------------QQQHQSATXELQHRPHIQLTGSPSSQQQQQSFQTPPS-------------------------CM LVQRDSPS------------------------------------------------------------------------ --------------------------------------------------------FSEGE---DNLAYLSALAVREED- -------------RAEPSLSPDMYVHPGLEGAKLD--------------------------------------------- ---------------------------------PTELEEQESTCLR-----PESCGLVSREEAAEGAQ------------ ---------------------------GDPDRPAQKQRSRR-RPRVLFSQAQVFELERRFKQQRYLSAPEREHLATTLKL T---SNQVKIWFQNRRYKCKRQRQDKSLEAAGQHH--------------------------------------------- --PPPPRRVAVPV-------------------LVRDGKPCLGGAQ-----------SY--TAAP-----YGSNPYGYNGY SAYTYDS---------------PAYNSNYSCTYSS--------------------------------------------- IPALPPSS---------------TSS-AFMNMN------------LSNMSSLSGSPQPQPHQG------PAVSPCQGS-- -------LQGIRAW------------------------------------------------------------------ ---------------------------- >Caenorhabditis_elegans_NKX2-3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----MS-----------------------------------------------------------------EKETPSPVL DVKKEKNEETGIDEEK----------------SS---------------------------------------------- -------------------------------EDDCSKRSKVKSNPSKFSVNSILSPLESLVR------VQQQLLKMAASK SGTPGTNAG-VPGAFPYGPGRLP--------------------------------------------------------- ----------------------------------------------------------GNYFAGPFPGYSGAQPN----- -----------WYNGN-------DPRFAAAAALLPCS---------------IDPVRS---------------------- -----------------------------------------------------AINHQFSMSS----------------- -------------------------------------MSQRRKRRVLFSQAQVYELERRFKQAKYLTAPEREQLANSIRL T---PTQVKIWFQNHRYKCKRQEKEK----------------------------------------------AMSGLGHS EDGSSPPPD----------------------------------------------------------------------- -----------------------------NDDDDDKYSIEMDDK-------------------------DDEE------- ----EEES---------------EKPVLKPS---------------GVFGLPYPPNAAAAAAAAAAAFNFPFAAQGPN-- -------PAYYMRW------------------------------------------------------------------ ---------------------------- >Homo_sapiens_NKX2-4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M SLSPK-------------------------------------------------------------------HTTPFSVS DILSPIEETYKKFSG-AMDGAPP--GLGAPLG------------------------------------------------ -------------------------------AAAAYRAPPPGPS--SQAATVAG-MQPSHAMAGHNAAAAAAAAAAAAAA AATYHMP----PGVSQFPH------------------------------------------------------------- ----------------------------------------------GAMGSYCNGGLG---NMGELPAYTDGMRG---GA ATG--------WYGANP------DPRYSSISRFMGPS--------------AGVNVAG---------------------- ----------------------------------------------MG-SLTGIADAAKSLGPLHAAA------------ -----------------------------------AAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL T---PTQVKIWFQNHRYKMKRQAKDKAA---------------------QQLQQ------EGGLGPP------------P PPPPSPRRVAVPV-------------------LVKDGKPCQNG------------------------------------- --------------------------ASTPTPGQAGPQPP---------------------------------------- ----APTP---------------APELEELS---------------PSPPALHGPGGGLAALDAAAG-EYSGGVLGAN-- -------LLYGRTW------------------------------------------------------------------ ---------------------------- >Pan_troglodytes_NKX2-4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M SLSPK-------------------------------------------------------------------HTTPFSVS DILSPIEETYKKFSG-AMDGAPP--GLGAPLG------------------------------------------------ -------------------------------AAAAYRAPPPGPS--SQAATVAG-MQPSHAMAGHNAAAAAAAAAAAAAA AATYHMP----PGVSQFPH------------------------------------------------------------- ----------------------------------------------GAMGGYCNGGLG---NMGELPAYTDGMRG---GA ATG--------WYGANP------DPRYSSISRFMGPS--------------AGVNVAG---------------------- ----------------------------------------------MG-SLTGIADAAKSLGPLHAAA------------ -----------------------------------AAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL T---PTQVKIWFQNHRYKMKRQAKDKAA---------------------QQLQQ------EGGLGPP------------P PPPPSPRRVAVPV-------------------LVKDGKPCQNG------------------------------------- --------------------------ASTPTPGQAGPQPP---------------------------------------- ----APTP---------------APELEELS---------------PSPPALHGPGGGLAALDAAAG-EYSGGVLGAN-- -------LLYGRTW------------------------------------------------------------------ ---------------------------- >Danio_rerio_NKX2-4_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M SLSPK-------------------------------------------------------------------HTTPFSVT DILSPIEETYKKFS--GMESTG---NLTSPLG------------------------------------------------ ----------------------------------AYRQPQVSQT--GMQQHSMG---------------------HNATV ATTYHMP----HSVSQFSH------------------------------------------------------------- ----------------------------------------------SAMGGYCNGSIA---NMGDLPSYQETMRNS--AA ATG--------WYGANP------DPRYSTISRFMGPS--------------TGMNMTG---------------------- ----------------------------------------------MG-TLTGMADTTKSIPPLH--------------- -------------------------------------AAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL T---PTQVKIWFQNHRYKMKRQAKDKAA---------------------QQLQQ------EGNLCQQQ------------ ---QSPRRVAVPV-------------------LVKDGKPCQNG------------------------------------- --------------------------SNTPTPNQQQMQQ------------QQNG--------GGVVLPTSSNSMNQHQS QQVNALVQ---------------AQDLEEMS---------------PSPPSLHSQMNSMGQIDTS--VDYTNNMVTSN-- -------LLYGRTW------------------------------------------------------------------ ---------------------------- >Takifugu_rubripes_NKX2-4_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------IM SLSPK-------------------------------------------------------------------HTTPFSVT DILSPIEETYKKFS--GMDGAG---NLTSPLG------------------------------------------------ ----------------------------------AYRQPQVSQT--GMQQHSMG---------------------HNATV ATTYHMP----HGVSQFSH------------------------------------------------------------- ----------------------------------------------SAMGGYCNGSIG---NMGDLPSYQESMRNS--AA ATG--------WYSANP------DPRFSTISRFMGPS--------------TGMNMTG---------------------- ----------------------------------------------MG-GLTGMADATKSMPALH--------------- -------------------------------------AAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL T---PTQVKIWFQNHRYKMKRQAKDKAA---------------------QQLQQQQQQQQDGNLCQQQA----------- ---QSPRRVAVPV-------------------LVKDGKPCQNG------------------------------------- --------------------------SSTPTSNQQQVQQSQQQS------QQQNG--------NGVLLASPTGNLSQHQN QQQ---VN---------------ALDLEEMS---------------PSPPSLHSQLN-MAQIDTSA-VDYTSNMVTSN-- -------LLYGRTW------------------------------------------------------------------ ---------------------------- >Nematostella_vectensis_NKX2-4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M LHPTNPT-------------------------------------------------------------------APFTVR NLLSLSEFHP---------------------------------------------------------------------- ---------------------------------NYKEAGQSDCLTQMTSIHT---------------------------M ASKLEPSTTSGLHMHDS--------------------------------------------------------------- ------------------------------------------------------HNQSYLYGDTTRPMYMKSDSSQAAN- ------------SNTSTSQILDGSAQVSMDPELSS--------------------------------------------- ---------------------------------KPESQDMHSDLQTS----QATSNGTELQQLTNSCNG----------- ---------------------------SMSSEVGNKPKRIRRKPRVLFSQAQVYELERRFKGQKYLSAPERDHLASLLKL T---PNQVKIWFQNKRYKCKKQAMENKARAAGMESWYG------------------------------------------ -LPPEPRRVAVPV-------------------LVRDGETCFGREP-----------------YG-----YNMN------- -------------------------------------------------------------------------------- -TNMNMNF---------------PPPHYMN---------------------------MYPQQGGNP---------LTN-- -------RSCPSQW------------------------------------------------------------------ ---------------------------- >Homo_sapiens_NKX2-5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M FPSP--AL----------------------------------------------------------------TPTPFSVK DILNLEQQ------------------------------------------------------------------------ ----------------QRS--------------LAAAGELSARLEATLAPSS--------------------------CM LAAFKPEAYAGP-------------------------------------------------------------------- -------------------------------------------------------EAAA-PGLPELRAELGRAPSPAKC- -----------ASAFPA--APAFYPRAYSDPDPAK--------------------------------------------- ---------------------------------DPRAEK------------KELCALQKAVELEKT-------------- ---------------------------EADNAERPRARRRR-KPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKL T---STQVKIWFQNRRYKCKRQRQDQTLELVGLPPPPP------------------------------------------ --PP-ARRIAVPV-------------------LVRDGKPCLG-DS-----------APYAPAYG-----VGLNPYGYNAY P----------------------AYPGYGGAACSPG------------------------------------YSCTAAYP AGPSPAQP---------------ATAAANN-----------------NFVNFGVG-DLNAVQSPGI---PQSNSGVST-- -------LHGIRAW------------------------------------------------------------------ ---------------------------- >Mus_musculus_NKX2-5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M FPSP--AL----------------------------------------------------------------TPTPFSVK DILNLEQQ------------------------------------------------------------------------ ----------------QRS--------------LASG-DLSARLEATLAPAS--------------------------CM LAAFKPEAYSGP-------------------------------------------------------------------- -------------------------------------------------------EAAA-SGLAELRAEMGPAPSPPKC- -----------SPAFPA--APTFYPGAYGDPDPAK--------------------------------------------- ---------------------------------DPRADK------------KELCALQKAVELDKA-------------- ---------------------------ETDGAERPRARRRR-KPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKL T---STQVKIWFQNRRYKCKRQRQDQTLELLG---PPP------------------------------------------ --PP-ARRIAVPV-------------------LVRDGKPCLG-DP-----------AAYAPAYG-----VGLNAYGYNAY P-----------------------YPSYGGAACSPG------------------------------------YSCAA-YP AAPPAAQP---------------PAASANS-----------------NFVNFGVG-DLNTVQSPGM---PQGNSGVST-- -------LHGIRAW------------------------------------------------------------------ ---------------------------- >Danio_rerio_NKX2-5_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------MM LPSPVTS-------------------------------------------------------------------TPFSVK DILKLEQQTR---------------------------------------------------------------------- ----------------QLQS----------LHPASHHAQLHPELQDRFQAPSS-------------------------CF LGGGDSP------------------------------------------------------------------------- -------------------------------------------------------GFSDNE---EKMSFLNSLSMQDS-- -------------LVESSLSPPMFVHPALG---HV--------------------------------------------- ---------------------------------DTKLE-DELEDHE-----TKSCGAILRTPECEAEV------------ ---------------------------HSDTERAQRQRTRR-KPRVLFSQAQVFELERRFKQQRYLSAPEREHLASTLKL T---STQVKIWFQNRRYKCKRQRQDKTLEMAGHHH--------------------------------------------- --PPPPRRVAVPV-------------------LVRDGKPCLTGSQ-----------SYNTTYAV-----N-PGPYTYNGY S--SYNN---------------AAYTNPYSCTYPS--------------------------------------------- LPPLP-AN---------------TSTNALMSMS------------LNNLGTYS---QPQTSQG------TPVSACQGT-- -------LQGIRAW------------------------------------------------------------------ ---------------------------- >Takifugu_rubripes_NKX2-5_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------------LAM FPSP---S----------------------------------------------------------------TSTPFSVK DILNLEQS------------------------------------------------------------------------ ----------------HDV--------------IVSSLGVSPRMDCCAAPTSSS--------------------SSSSCM LARLKQEPPRDM-------------------------------------------------------------------- -------------------------------------------------------S-TTAASMFGEDPQDTTRGGRGNA- -----------LCFPAT-----FYGKSFMEMDAVK--------------------------------------------- ---------------------------------GGKSDA---FEEKR---RKEDFSLPSESLGDIK-------------- ----------------------------SEDPERPKARRRR-KPRVLFSQAQVYELERRFKQQRYLSAPERDHLAGVLKL T---PTQVKIWFQNRRYKCKRQRQDQSLEMVSLPPP-------------------------------------------- ------RRVSVPV-------------------LVRDGKPCLAADT-----------ASYNPSYS----MSHINHFTYNNY P----------------------AFSNYTSPGCNTN------------------------------------YACN--YP AAA-TIQP---------------MQGSPNSG----------------NYVNF--G-DLNNVQN---T--FTSTNGVSS-- -------LHGIRTW------------------------------------------------------------------ ---------------------------- >Amphimedon_queenslandica_NKX2-5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------------MSSGKK KSFMICDILD---------------------------------------------------------------------- ---------------------------------DIYTSDSSRPSSTELQVHPHI------------------------VH SSSVIYTASAAPSHIEGGLV------------------------------------------------------------ ----------------------------------------------------GGEGDECSPGTDSGLGDCKPEAIRPESP T--------------------QHEPDSPSSSQ------------------------------------------------ -----------------------------------------------------SSEQGSTGAAKT--------------- ---------------------------------------RKRRPRGLFSHAQIYELERRYALQKYLTAHEREQLANMLRL T---ETQVKIWFQNRRYKNKRQQLENARLSPKSAVAACSK------------------------------TSDLFPSAIP PPPPLHSIAAAPSDI-----------------KLPSTTPAFPVNSPLS-------------------------------- ----------------------LNLTHAPPSALPIGVVATSLIT-----------------------PSGTQSPLYSITG PPPSLP-----------------PPSDYSFRYPSGHPPPIMNIKSTPPSLPKSMYYPAVAAAYGGSVTSVNATIPSGSYV SSICSCTTMPYQPLPRVPSPATSVTSIRSQY------------------------------------------------- ---------------------------- >Homo_sapiens_NKX2-6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M LLSPVTS-------------------------------------------------------------------TPFSVK DILRLERE------------------------------------------------------------------------ ----------------------------------RSCPAASPHPRVRKSPEN--------------------------FQ YLRMDAEPRGSE-------------------------------------------------------------------- -------------------------------------------------------VHNAGGGGG-DRKLDGSEPPGGPC- -----------EAVLEMDAERMGEPQPGLNAASP---------------------------------------------- -------------------------------------------------LGGGTRVPERGVGNSGDSV------------ ---------------------------RGGRSEQPKARQRR-KPRVLFSQAQVLALERRFKQQRYLSAPEREHLASALQL T---STQVKIWFQNRRYKCKRQRQDKSLELAGHPLT-------------------------------------------- -----PRRVAVPV-------------------LVRDGKPCLGPGPG---------APAFPSPYS-----AAVSPYS---- -----------------------CYGGYSGAPYGAG--------------------------------------YGTCYA GAPSGPAP---------------HTPLASA--------------------GFGHGGQNATPQGHLA----------AT-- -------LQGVRAW------------------------------------------------------------------ ---------------------------- >Mus_musculus_NKX2-6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M LSSPVAS-------------------------------------------------------------------TPFSVA DILRLECQ------------------------------------------------------------------------ ----------------------------------QKDSKTLSQWELHRNPVK--------------------------PR YLRMNQESGWFE-------------------------------------------------------------------- -------------------------------------------------------SSDRAQAVP----------FRCTW- -----------ETVLEMGSNPVGEPQTPPGTISR---------------------------------------------- -------------------------------------------------LGARNPMTDRGVGNLSGDM------------ ---------------------------RRGGPVSTRTRPQR-KSRVLFSQAQVLALERRFKQQRYLTAPEREHLASALQL T---STQVKIWFQNRRYKSKSQRQDQTLELAGHPLA-------------------------------------------- -----PRRVAVPV-------------------LVLDGKPCLDPD-----------VAAFLGPY------KATSPYS---- -----------------------CFGGYAGTPYDAS--------------------------------------YASRCT SASAGPGP---------------LTPLASS--------------------GFSPGGQSAAPQGHLP----------AT-- -------PQGVTAW------------------------------------------------------------------ ---------------------------- >Homo_sapiens_NKX2-8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MATS-------------------------------------------------------------------GRLSFTVR SLLDLPEQD---------AQHLPR-------------------------------------------------------- ------------------------------------------------------------------------------RE PEPRAP-QPDPCAAWLDSE------------------------------------------------------------- ------------------------------------------------------------RGHYPSSDESSLETSPPDSS Q----------------------RPSARPASP------------------------------------------------ -----------------------------------------------------------GSDAE---------------- ---------------------------------------KRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRL T---PTQVKIWFQNHRYKLKRARAP---GAAE-------------------------------------SPDLAASAELH AAPGLLRRVVVPV-------------------LVRDGQPCGG-------------------------------------- --------------------------------------------------------------------------GGGGEV GTAAAQEK----------------CGAP------------------PAAACPLPGYPAFGPGS--ALGLFPAYQ-HLA-- -------SPALVSWNW---------------------------------------------------------------- ---------------------------- >Mus_musculus_NKX2-8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MATS-------------------------------------------------------------------GRLGFTVR SLLNLPEQD---------AKPRVR-------------------------------------------------------- ------------------------------------------------------------------------------RE QQTCVP----QTAAWLESE------------------------------------------------------------- ------------------------------------------------------------CSHYLSSDESGLETSPADSS Q----------------------LASLRRESP------------------------------------------------ -----------------------------------------------------------GSDPE---------------- ---------------------------------------KRRKRRVLFSKAQTLELERRFRQQRYLSAPEREQLARLLRL T---PTQVKIWFQNHRYKLKRGRAP---GITE-------------------------------------PSDMAASSDLH AAPGLLRRVVVPV-------------------LVHDRPPSNN-------------------------------------- ---------------------------------------------------------------------------GRGEG TSAVPQDK----------------CSAR------------------LATACPVPGYTAFGPGS--ALGLFPAYQ-HLA-- -------PPALVSWNW---------------------------------------------------------------- ---------------------------- >Takifugu_rubripes_NKX2-8_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MAAP-------------------------------------------------------------------TKFSFSVR SILDLPERD---------VEAAP--------------------------------------------------------- -----------------------------------------------------------------------------RSS PLFS-CSSRSPYTAWMECD------------------------------------------------------------- ------------------------------------------------------------RSPCISSDEGGLEAS-PDST K----------------------PDDSSLDSE------------------------------------------------ -----------------------------------------------------------PDKNK---------------- ---------------------------------------KSKKRRVLFSKAQTLELERRFRQQRYLSGPEREQLARLLSL T---PTQVKIWFQNHRYKMKRGRAEG-----------------------------------------------GLQDMEM PQSSVLRRVVVPI-------------------LVRDGKPFHP-------------------------------------- -----------------------------------------------------------------------------CLL DPE---KA---------------ACLPGS-----------------PAAPFPLT-YSSLQHAS--PVGLPPRYQQHFH-- -------TAAASRFAWRDFWSDSVHFNSFK-------------------------------------------------- ---------------------------- >Ciona_intestinalis_NKX2-8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M SVSPKH-----------------------------------------------------------------STTTPFSVT DILSPLEESYGTGSVEGIVSGRREFSELYSNMES---------------------------------------------- -------------------------------GAASSAGIHVPNLGGGGSTGSISSPMTSYRQPMMGTPPHHSIHHQQMSS ANPYQTAAG-MNGSYNLHPMPTPPQTS----------------------------------------------------- ---------------------------------------------FHAMPGSGGPTGYGNGGVPELPPYNNVQSP----- -----------WYGAPSN----PDPRFVPSYPRLQITGY-----------GSMMPGTG---------------------- -----------------------------------------------------MDGMHKTLLP----------------- -------------------------------------PSQRRKRRVLFSQAQVFELERRFKQQKYLSAPEREHLAQMIHL T---PTQVKIWFQNHRYKNKRSLKDKQTQEMSVQQQQQQQQQSQTSGNAQPQHTNDLSHSNPSQLQPVAS-AVPGGTRTP QETYSPVPTGVQA-------------------SQPGMVDGNDG------------------------------------- --------------------HRMVHISNQNGDQSSPRHLTMSDG-SCHDSTIIESPNMQMPMPNVVQPTDTEAGLGPFSS VIKLEEVN---------------VDSAEGSG---------------GNSGNIVPQTHYLGSTHHHDLMNVNVTTLNAV-- -------DAYQHHPHHNHIPIGNTVLNDQSILYSVYR------------------------------------------- ---------------------------- >Caenorhabditis_elegans_NKX2-8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------MFNV SALAAA------------------------------------------------------------------TPSIASVS SVASPSEQHGLSTSVGVGVNDTTSRTGDG--------------------------------------------------- --------------------------------GAASSASSASAAPQQQSQSALH-------------------NKLEAKW DTLLPTDTNLQCSTWPDSIPLLAG-------------------------------------------------------- -----------------------------------------YSATPTFSFDPCTYGSYDPSAYFASNGIAGSMYTLPDQF PR----------SENDMLDNSNTSNGNKSDKDGIKLEDE-----------DE---------------------------- ----------------------------------------------------ILEDEENDEEDDGTGK------------ --------------------------------------RKKRKRRVLFTKAQTYELERRFRSQKYLSAPEREALAMQIRL T---PTQVKIWFQNHRYKTKKSHTDKPINAALLT-----------------------------------TMPNAFSSQST AASFPTRAMPIPM-------------------LVRDSSARSS-------------------------------------- ----------------------------------------------------------------------------DISS TSPYTVAF---------------GSANSGYLP--------------TPSAYLPATSGYFSNGPSAAS---------SY-- -------MTNTQWWPS---------------------------------------------------------------- ---------------------------- >Homo_sapiens_NKX3-1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MLRVPEPRPGEAKAEG----AAPPTPSKPLTSFLIQ DILRDGAQRQGG-RTSSQR------------------------------------------------------------- ----------------QRD--PEPEPEPEPEGGRSRAGAQNDQLSTGPRAAPEEAE------------------------ -TLAETEP------------------------------------------------------------------------ -----------------------------------------------------------------ERHLGSYLLDSE--- -------------------------------------------------------------------------------- -----------------------------------------------------NTSGALPRLPQTP-------------- -------------------------------------KQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKL T---ETQVKIWFQNRRYKTKRKQ--LSSELGDLEKH-------------------------------------------- ---S--SLPALK-------------------------------------------------------------------- --------------------------------------------------------------------------EEAFSR ASLVS-VY---------------NSYPYYPYLY-----------------CVGS--WSPAFW------------------ -------------------------------------------------------------------------------- ---------------------------- >Mus_musculus_NKX3-1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MLRVAEPREPRVEAGGRSPWAAPPTQSKRLTSFLIQ DILRDRAERHGG-HSGNPQHS----------------------------------------------------------- -----------------------PDPRRDSAPEPDKAGGRGVAPEDPPSIRHSPAE------------------------ -TPTEPES------------------------------------------------------------------------ -----------------------------------------------------------------DAHFETYLLDCE--- -------------------------------------------------------------------------------- -----------------------------------------------------HNPGDLASAPQVT-------------- -------------------------------------KQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKL T---ETQVKIWFQNRRYKTKRKQ--LSEDLGVLEKN-------------------------------------------- ---SPLSLPALK-------------------------------------------------------------------- --------------------------------------------------------------------------DDSLPS TSLVS-VY---------------TSYPYYPYLY-----------------CLGS--WHPSFW------------------ -------------------------------------------------------------------------------- ---------------------------- >Danio_rerio_NKX3-1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------SRAVQSESDN---------YQPGERGFIFT FIGSLAAQMATSNKQLTSFF------------------------------------------------------------ -----------------------IEDILSLKEDKKDEDSCNAESDR------------D--------------------- -DSTDRQT------------------------------------------------------------------------ -----------------------------------------------------------------D------SADTC--- -------------------------------------------------------------------------------- -----------------------------------------------------RTSEGKTVSSTEMTGG----------- -------------------------------------GGKKKRSRAAFTHLQVLELEKKFSRQRYLSAPERTHLASALHL T---ETQVKIWFQNRRYKTKRRQ--LTTEHSKDYFQ-------------------------------------------- ---KSNAAAMAAT------------------------------------------------------------------- --------------------------------------------------------------------------EEDFFR ASLLATVY---------------KSSPYRPYVYD----------------LHGLSMWRPAL------------------- -------------------------------------------------------------------------------- ---------------------------- >Anopheles_gambiae_NKX3-1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------MSLTASTAKS----IVSTPFSIN DILTRSRRVERHSSGESSGNEEDMQTFYHPRHHHNHYHAQHTRHTQHVRRG----------------------------- --------------------TLEPSGSPRSTVEEGLYGKLSMSYYNNNNNNNNATTPSGFPVNGLPPALRRGSLDCFMVS AEPVREHGEDVAARPDTGDGGGDGGNPSERI------------------------------------------------- ----------------------------------------------------------ASMLLEGARPSASVTATCYRLS KAA----------HQRS--ESPIDMRRLAENDSDCDSSPS---------------------------------------- ------------------------------------------PYTGSLGLHGGQATTLHTSEEMPS-------------- --------------------------------------ARKKRSRAAFSHAQVFELERRFAQQRYLSGPERSELAKNLRL T---ETQVKIWFQNRRYKTKRKQIQQHEAALLSATK-------------------------------------------- ---RVPVQVLVRE-------------------DGS--YGPMLAAGQPHYATGLDP------------------------- --------------------------------------------------------------------ALLNVYRHQIQM AYGMPGIP-----------------SMPFSYFYPSKMATVPN------GPIAPSVVLSAPSSSSSSSSNSCKPPSSHHGP LQAASSGPLNFSTRCDSDAENVNSTGRRSPSELSGPGSDDVRSRSRMDVDVSGHCSVLSSAGEGDEDECENVEID----- ---------------------------- >Homo_sapiens_NKX3-2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MAVRGANTLTSFSIQ AILNKKEERG---GLAAPEGRPAPG-GTAASVAA--APAVCCWRLFGERDAGALGGAEDSLLASPAGTRTAAG------- ----------------------RTAESPEGWDSDSALSEENESR--RRCADARGASGAGLAGGSLSLGQPVCEL----AA SKDLEEEA------------------------------------------------------------------------ ----------------------------------------------------------------AGRSDSEMSASVSGD- -------------RSPRTEDDGVGPRGAHVSALCSGAG------------------------------------------ ------------------------------------------GGGGSGPAGVAEEEEE-PAAPKP--------------- ---------------------------------------RKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKL T---ETQVKIWFQNRRYKTKRRQ--MAADLLASAP--------------------------------------------- ----AAKKVAVKV-------------------LVRDDQRQYLP------------------------------------- --------------------------------------------------------------------------GEVLRP PSLLPLQP---------------S--YYYPY------------------YCLPGWALSTCAAAAGTQ------------- -------------------------------------------------------------------------------- ---------------------------- >Mus_musculus_NKX3-2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MAVRGSGTLTPFSIQ AILNKKEERG---GLATPEGRPAPG-GTEVAVTA--APAVCCWRIFGETEAGALGGAEDSLLASPARTRTAVG------- ----------------------QSAESPGGWDSDSALSEENEGR--RRCADVPGASGTGRARVTLGLDQPGCEL----HA AKDLEEEA------------------------------------------------------------------------ ----------------------------------------------------------------PVRSDSEMSASVSGD- -------------HSPRGEDDSVSPGGARVPGLRGAAG------------------------------------------ ------------------------------------------SGASGGQAGGVEEEEE-PAAPKP--------------- ---------------------------------------RKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKL T---ETQVKIWFQNRRYKTKRRQ--MAADLLASAP--------------------------------------------- ----AAKKVAVKV-------------------LVRDDQRQYLP------------------------------------- --------------------------------------------------------------------------GEVLRP PSLLPLQP---------------S--YYYPY------------------YCLPGWALSTCAAAAGTQ------------- -------------------------------------------------------------------------------- ---------------------------- >Danio_rerio_NKX3-2_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------MANNRTSFSIH NILNQGHECG---KNGSFDEEYE-----------------------GEKRTQDSGSSVPVN------------------- ----------------------RGAESAQTRISSCVLVLESLSS--DQHSCEEESTGED--------------------- -NSLERRH------------------------------------------------------------------------ ----------------------------------------------------------------DHEMDQQKPQSCSFE- -------------DS----------------------------------------------------------------- -------------------------------------------------------------NPKS--------------- ---------------------------------------SKKRSRAAFSHAQVYELERRFNLQRYLSGPERADLAGALKL T---ETQVKIWFQNRRYKTKRRQ--MAAELATTPTT-------------------------------------------- ---TLAKRVAVKV-------------------LVRNDQRQYN-------------------------------------- --------------------------------------------------------------------------TEDLPS PSVPPLYQ---------------S-FPYYPY-----------------MFCFQPWISGNTLSGGMY-------------- -------------------------------------------------------------------------------- ---------------------------- >Takifugu_rubripes_NKX3-2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------MAVRG-NSLMPFSIQ AILNKKDESR---HLPDLDMCFSKT---------------ACWKIFGEMNGASRRGDDDVS------------------- ----------------------CEQTNPKNYDSDSGLSEDNDSK--IPVPCTSEKHGDP--------------------- ASDVPEES------------------------------------------------------------------------ ----------------------------------------------------------------LQ-ETDHESATAENA- -------------KSDSEPSNTTG------FISVPDSS------------------------------------------ -----------------------------------------------------TVEDKSPDQPKQ--------------- ---------------------------------------RKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKL T---ETQVKIWFQNRRYKTKRRQ--MAADLMASTP--------------------------------------------- ----AAKKVAVKV-------------------LVRDDQRQYSP------------------------------------- --------------------------------------------------------------------------GELLRP P-LLSLQP---------------S--YYYPYA-----------------YCLPAWTLS---ACAGNQ------------- -------------------------------------------------------------------------------- ---------------------------- >Drosophila_melanogaster_NKX3-2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------MLNMESAGVSAAMAGLSKSLTTPFSIN DILTRSNPETRRMSSVDSEPE-----------------PEKLKPSSDRER------------------------------ --------------------SISKS-PPLCCRDLGLY-KLTQ----PKEIQPSARQPSNY-------------LQYYAAA MDNNNHH------HQATG-------------------------------------------------------------- --------------------------------------------------------------------TSNSSAADYMQR KLA----------YFGSTLAAPLDMRRCTSNDSDCDSPP----------------------------------------- ------------------------------------------PLSSSP----SESPLSHDGSGLS--------------- ---------------------------------------RKKRSRAAFSHAQVFELERRFAQQRYLSGPERSEMAKSLRL T---ETQVKIWFQNRRYKTKRKQIQQHEAALLGASK-------------------------------------------- ---RVPVQVLVRE-------------------DGSTTYAHMAAPGAGH---GLDP------------------------- --------------------------------------------------------------------ALINIYRHQLQL AYGGLPLP---------------QMQMPFPYFYP--QHKVP-------QPIPPPTQSSSFVTASSASSS----------P VPIPIPG-----------AVRPQRTPCPSPN-------------GQMMSVESGAESVHSAA----EDVDENVEID----- ---------------------------- >Homo_sapiens_NKX6-1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MLAVG-AMEGTRQSA-------------------------------FLLSSPPLAAL HSMAEMKT-PLYPAAYPPLPAGPPSSSSSSSSSSS--------------------------------------------- -------------PSPPLGTHNPGGLK-----PPATGGLSSLGSPPQQLSAA---------------------------T PHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSA------------------------------------------- ---------------------------------------SASSASAAAAAAAAAAAAASS-PAGLLAGLPRFSSLSPPPP PP-GLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVM----------------------------------------- -----------------------------------------------QSP-PWRDARLACTPHQGS-------------- -------------------------------ILLDKDGK-RKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGM T---ESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETER---------------------------------------- -----LKGASENE---------------------EEDDDYNKP------------------------------------- --------------------------------------------------------------------------LDPNSD DEKITQLL--------------KKHKSSSG--------------GGGGLLLHASEPESSS-------------------- -------------------------------------------------------------------------------- ---------------------------- >Mus_musculus_NKX6-1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MLAVG-AMEGPRQSA-------------------------------FLLSSPPLAAL HSMAEMKT-PLYPAAYPPLPTGPPSSSSSSSSSSS--------------------------------------------- -------------PSPPLGSHNPGGLK-----PPAAGGLSSLGSPPQQLSAA---------------------------T PHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSA------------------------------------------- ---------------------------------------SATSASAAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPP PP-GLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVM----------------------------------------- -----------------------------------------------QSP-PWRDARLACTPHQGS-------------- -------------------------------ILLDKDGK-RKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGM T---ESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETER---------------------------------------- -----LKGTSENE---------------------EDDDDYNKP------------------------------------- --------------------------------------------------------------------------LDPNSD DEKITQLL--------------KKHKSSGGS-----------------LLLHASEAEGSS-------------------- -------------------------------------------------------------------------------- ---------------------------- >Danio_rerio_NKX6-1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MLAVG-QMDGSRQSA-------------------------------FLLNTPPLAAL HSMTEMKT-PLYP-AYPLSSTGPASSTSPTATSPN--------------------------------------------- --------------PGGIP-VSSPGIK-------TSSGLSA-LASAQQCAIA---------------------------T PHGINDILSRP--------------------------------------------------------------------- --------------------------------------------S------------VACSPAGILSGLPRFSSLSPPPP PG--LYFSPSAAA-VAVARYPKPLTELPGRTPIFWPGVM----------------------------------------- -----------------------------------------------QSP-HWRDARFACSPHQNS-------------- -------------------------------VLLDKDGK-RKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGM T---ESQVKVWFQNRRTKWRKRHAAEMASAKKKQDSETER---------------------------------------- -----LKGASENE