>Homo_sapiens_NIPAL1 -----------------------------------------------------------MGA--QVRLPPGEPCREGYVL SLVCP-NSSQAWCEITNVSQLLASPVLYTDLN-------YSINNLSISANVENKYSLYVGLVLAVSSSIFIGSSFILKKK GLLQLASKGFTRAG--QGGHSYLKEWLWWV--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLIS---AILSSYF LNEHLNIHG--------KIGCILSILGSTVMVIHAPQEEEVTSLHEMEMKLRDP--GFISFAVII--------TVISLVL ILIVAPKKGQTNILVYISICSLIGAFSVSSVKGLGIAIKELIEWKP-----VYKHPLVFVLLAVLVL--SVTTQINYLNK ALDTFNT-SLVTPIYYVFFTSMVVTCS-----AILFQEWYGMTAGDIIGTLSGFFTIIIGIFLLHAFKNTDITWSELTST AKKEAVS-------LNVNENN----YVLLEN----------------LECSAPGYNDDVTLFSRTDD------------- ------------------------- >Pan_troglodytes_NIPAL1 -----------------------------------------------------------MGA--QVRLPPGEPCREGYVL SLVCP-NSSQAWCEITNVSQLLASPVLYTDLN-------YSINNLSISANVENKYSLYVGLVLAVSSSIFIGSSFILKKK GLLQLASKGFTRAG--QGGHSYLKEWLWWV--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLIS---AILSSYF LNEHLNIHG--------KIGCILSILGSTVMVIHAPQEEEVTSLHEMEMKLRDP--GFISFAVII--------TVISLVL ILIVAPKKGQTNILVYISICSLIGAFSVSSVKGLGIAIKELIEWKP-----VYKHPLVFVLLAVLVL--SVTTQINYLNK ALDTFNT-SLVTPIYYVFFTSMVVTCS-----AILFQEWYGMTAGDIIGTLSGFFTIIIGIFLLHAFKNTDITWSELTST AKKEAVS-------LNVNENN----YVLLEN----------------LECSAPGYNDDVTLFSRTDD------------- ------------------------- >Mus_musculus_NIPAL1 -----------------------------------------------------------MGV--QLRLPPGEPCHEGYVL SLVCS-NSSRASCEITNVSESLPYPVVYTNLN-------SSKTNFSISASVENKYNLYVGLVLAISSSVFIGSSFILKKK GLLQLADKGITRAG--QGGHSYLKEWLWWA--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLIS---AILSSYF LNERLNIHG--------KIGCILSVLGSTVMVIHAPQEGEVTSLHEMEMKLRDP--GFVSFAVII--------SVISLVL ILIVAPKKGQTNILVYIAICSLIGAFSVSSVKGLGIAIKELLERKP-----VYKDPLFFILLTMLAL--SVTTQINYLNK ALDTFNT-SLVTPIYYVFFTSMVVTCS-----AILFQEWYGMKAGDIIGTLSGFFTIINGIFLLHAFKNTNITWSELMST AKKEALS-------PNGNQNS----YVLLEN----------------ADFSASGYDDDITLFSRTNDQSSHKL------- ------------------------- >Rattus_norvegicus_NIPAL1 -----------------------------------------------------------MGA--QLRLPPGEPCREGYVL SLVCS-NSSQALCEITNVSQPLAYPVLYTNPN-------SSTSNFSISAGVENKYSLYVGLVLAISSSFFIGSSFILKKK GLLQLADKGITRA--------------------------VGAGEAANFAAYAFAPATLVTPLGALSVLIS---AILSSYF LNEHLNIHG--------KIGCILSILGSTVMVIHAPQEGEVTSLHEMEMKLRDP--GFISFAVIV--------SVISLVL ILVVAPRKGQTNILVYISICSLIGAFSVSSVKGLGIAIKELLERKP-----VYKDPLVFILLAVLTL--SVTTQINYLNK ALDTFNT-SLVTPIYYVFFTSMVVTCS-----AILFQEWYGMRAGDIIGTLSGFFTIINGIFLLHAFKNTNITWSELTST AKKEVLS-------SNGSQNS----YVLLEN----------------ADCSTSGCDDDITLFSRTGDQSIHKL------- ------------------------- >Ornithorhynchus_anatinus_NIPAL1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------G--QGGHSYLKQWLWWA--GLLS---MGLGEAANFAAYAFAPATLVTPLGALSVLVS---AILSSYF LHERLNVHG--------KLGCVLSLLGSTVMVIHAPEEEEVTSLADMEAKLRDP--GFVCFAVVV--------VVTSLVL ILVVAPRKGQNNILVYVSICSAIGAFSVSSVKGLGIAMKDLMEQKP-----VYRDPLVFVLLATLVL--SISTQINYLNK ALDTFNT-SLVTPIYYVGFTSMVLTCS-----IILFKEWHDLGARDVLGTLSGFGTIIGGIFLLHAFRGVPPSWSQLSAP VRKGVASA------LSAGEDG----HALLEH----------------VECSRLGCDDDLTLFSRVGG------------- ------------------------- >Homo_sapiens_NIPAL2 -------------------------------------------------------------------------------- -MAAVAPAGPGDS-ASAALDELSLNFTYGAPGAGNGSLSG--------DWYRRNQIHLFGVLLAILGNLVISISLNIQKY SHLQL--------AQQEHPRPYFKSVLWWG--GVLL---MAVGETGNFAAYGFAPITLIAPLGCVSVTG---SAIISVTF LKDNLRASDLLG--------TTLAFAGTYLLVNFAPNITQAISARTVQYYLVGWQ--FLIYVILE--------ILIFCIL LYFYKRK-GMKHMVILLTLVAILAS--LTVISVKAVSGMITFSVMD----KMQLTYPIF-YIMFIIMIASCVFQVKFLNQ ATKLYNT-TTVVPVNHIFFTISAIIA-----GIIFYQEFLGAPFLTVFIYLFGCFLSFLGVFLVTRNR-EKEHLQQSYID FGNIP-------GKQMLDKIQPDSHSLSYGTLPDGSDSTKSQSGEKKEV------------------------------- ------------------------- >Pan_troglodytes_NIPAL2 -------------------------------------------------------------------------------- -MAVLAPAGPGDA-ASAALDELSLNFTYGAPGAGNGSLSG--------DWYRRNQIHLFGVLLAILGNLVISISLNIQKY SHLQL--------AQQEQPRPYFKSVLWWG--GVLL---MAVGETGNFAAYGFAPITLIAPLGCVSVTG---SAIISVTF LKDNLRASDLLG--------TTLAFAGTYLLVNFAPNITQAISARTVQYYLVGWQ--FLIYVISE--------ILIFCIL LYFYKRK-GMKHMVILLTLVAILAS--LTVISVKAVSGMITFSMMD----KMQLTYPIF-YIMFIIMIASCVFQVKFLNQ ATKLYNT-TTVVPVNHIFFTISAIIA-----GIIFYQEFLGAAFLTVFIYLFGCFLSFLGVFLVTRNR-EKEHLQQSYID FGNIP-------GKQMLDKIQPDSHSLSYGTLPDGSDSTKSQSGEKKEV------------------------------- ------------------------- >Mus_musculus_NIPAL2 -------------------------------------------------------------------------------- -MAAPARTAPEDD-ASAVLDELSRNFTYWAPGPGNGSLSS--------AWYRRNQIHLFGVLLAILGNLVISISLNIQKY SHLHL--------AQKEHPKPYFKSVLWLS--GVLL---TALGETGNFAAYGVAPITLIAPLGCMSVTG---SAIISVIF LKENLRASDLLG--------MTLAFAGTYLLVNFAPNVTQAISARTVQYYFVGWQ--FLVYVILE--------ILVFCIL LYFHKRK-GMKHIVVLLTLVALLAS--LTVISVKAVSGMITLSVTG----KMQLTYAIF-YIMLVIMIASCVFQVKFLNQ ATELYTM-TTVVPVNHVFFTTSAIIA-----GIIFYQEFLGAAFLTVFIYLFGCFLSFLGVFLVTRNR-EKEHLQQSFVD LGDIP-------GKQMLDKVQPDSNGLSYGTLPDGGDSTRGQCGEKKES------------------------------- ------------------------- >Rattus_norvegicus_NIPAL2 -------------------------------------------------------------------------------- -MASPAPTGPQDD-ASAVLDELSRNFTYWAPGPSNGSLSS--------AWYHRNQIHLFGVLLAILGNLVISISLNIQKY SHLHL--------AQKEHPKPYFKSVLWLS--GVLL---MAIGETGNFAAYGVAPITLIAPLGCVSVTG---SAVISVIF LKENLRASDLLG--------MTLAFAGTYLLVNFAPNITQAISARTIQYYFVGWQ--FLVYMILE--------ILVFCIL LYFHKRK-GKKHIVILLTLVALLAS--LTVISVKAVSGMITLSVTG----KMQLTYAIF-YIMLVIMIASCVFQVKFLNQ ATELYTM-TTVVPVNHVFFTTSAIIA-----GIIFYQEFLGAAFLTVFIYLFGCFLSFLGVFLVTRNR-EREYLQQSFID FGNIP-------GKQMLDKIQPDSNGLSYGSLPDGGDSTRGQRAEKKEA------------------------------- ------------------------- >Pteropus_vampyrus_NIPAL2 -------------------------------------------------------------------------------- -MATLALADPQDA-AAAALDELPRNFTYGALSSGNGSLSG--------AWYRRNQIHLFGVLLAILGNLVISISLNIQKY SHLQS--------AHREHPRPFFRSVLWWV--GLVL---MAVGETGNFAAYGFAPITLIAPLGCMSVTG---SAIISVMF LKENLRASDLLG--------MTLAFAGTYLLVSFAPNITQAVSARTIQYYFVGWQ--FLIYVILE--------ILIFCIL LYFHKRK-GMKHIVILLTLAALLAS--LTVISVKAVSGMITFSVTD----KMQLTYPIF-YIMFIIMIASCVFQVKFLNQ ATKLYDT-TMVVPVNHIFFTTSAIIA-----GIIFYKEFLGEAFLTIFIYLFGCFLSFLGVFLVTRNR-EKEHLPQSYID FGNIP-------DTTRGNQLWRETN--------VG-NTTRFKQ------------------------------------- ------------------------- >Monodelphis_domestica_NIPAL2 -------------------------------------------------------------------------------- -MASLQQRGSGDEGFSETLDELDWNFTYGGQGVGNGSLSS--------FWYNRNQAHLFGVLLAVTGNLIISISLNIQKY SHLKL--------AHQGSQNPYFRSILWWC--GSLL---MVIGETGNCVGYGLAPVTLIAPLGCLSVAG---SAIMSVTF LRGNLRSSDLLG--------VTLAFAGTYLLVAFAPNITQDITAKKVRYYFVGWQ--FLAYVILE--------ILIFCIL LYFYKRK-DMKHIVILLTLVALLAS--MTVISVKAVSSMIILSVKG----EMQLTYPIF-YIMFIIMIASCIFQVKFLNQ AMKLYDM-TTVVSLNHIFFSTSAIVA-----GIIFYQEFHGATLLGALMYLFGCFLSFFGVVLVTRNR-EKKHLQQSYID IGEIP-------GKQMLDKIQPESNGQSYGTLPDESNPMKSPGGDKKDI------------------------------- ------------------------- >Takifugu_rubripes_NIPAL2_a -------------------------------------------------------------------------------- ---------------------------------------------------------LLGIIISICGNVLISISLNVQKY THLRQ--------AERG-SKPYYTSPVWWF--GVVL---MGVGEMGNFAAYGFAPATLIAPLGCVSVIA---SAIISVVF LKETVRASDIFVLCSLSATGGTLAITGTYLLVTFAPHSSVHITAHLVQYYMFSWQ--FLLYLLIE--------VVVFSVL LYLYKRR-NVKHIVVVMLLVALLAS--LTVISVKAVSGMITESIKG----QLQFIYPIF-YVMLVVMFASCGFQIKFLNE AMKVFDA-TEVVPINFVFFTASAIIA-----GVVFYQEFQGLALLNIFMFLFGCLLCFLGVFLIARNRPKSKEPDLNFIR MEKIP-------RRSHTDKVQPEAKTLAYGAL------------------------------------------------ ------------------------- >Tetraodon_nigroviridis_NIPAL2_a -------------------------------------------------------------------------------- ---------------------MEINTSSQHALLWDALRAD--------VMENPLQMYLLGIIISVCGNVLISISLNIQKY THLRQ--------AERG-SKPYYTSGVWWF--GVIL---MGVGELGNFAAYGFAPATLIAPLGCVSVIA---SAIISVVF LKETVRASDIL--------GGTLAITGTYLLVTFAPHNSVHITAHLVQYYMLCWQ--FLLYLFIE--------VVVFCVL LYLYTRR-NVKHIVVVMLLVALLAS--LTVISVKAVSGMITETIKG----QLQFIYPIF-YVMLVVMFASCGFQIKFLNE AMKMFDA-TEVVPINFVFFTASAIIA-----GVVFYQEFQGLALLNIFMFLFGCLLSFLGVFLIARNRPKRKEPDRNFIR MEKIP-------GRSHTDKVQPEATTLTYGSLAAKLMCTSAVQTDAS--------------------------------- ------------------------- >Gasterosteus_aculeatus_NIPAL2_a -------------------------------------------------------------------------------- -------------------------------------------------------TYLLGIIISICGNILISISLNIQKY AHVRQ--------SQRD-SKPYYTSAVWWC--GVAL---MGIGELGNFAAYGFAPASLIAPLGSVSVIA---SAVISVIF LKETVRVSDVV--------GGSLAITGTYVLVTFAPHTITHITAHLIQYYIVSWY--FVLYLSLE--------VLLFCIL LYVYKKR-NVKHIVVVMLLVALLAS--LTVISVKAVSGMITETIKG----QLQFIYPIF-YVMLVIMIASCAFQIKFLNQ AMKMFDA-TEVVPINFVFFTASAIVA-----GIVFYQEFEGLALLNIFMFLFGCLLSFLGVFLIARNRPKIKQQDPDFIA LDKIP-------SRSHTDKVQPEANTQTYGSLAA---------------------------------------------- ------------------------- >Oryzias_latipes_NIPAL2_a -------------------------------------------------------------------------------- ------------------------MENASVSAQGQAHQAQ--------IMENPLQNYLLGILISICGNVLISFSLNIQKY AHVRQ--------AQRG-SKPYYTSGVWWC--GVTL---MGVGELGNFAAYGFAPASLIAPLGCVSVIA---SVVISVVF LKETVYTSDIV--------GGTLAITGTYLLVTFAPHTSTHITAHLVQYYFISWH--FLLYLLIE--------IILFCIL LYLYKRR-NVKHIVVVMLLVALLAS--LTVISVKAVSGMITESIQG----QLQLIYPIF-YVMLVVMVASCGFQIKFLNQ AMKMFDA-TEVVPINFVFFTTSAIVA-----GIVFYQEFEGLALLNILMFLLGCLLSFLGIFLIARNRPKIKQQDSNFIE MNRIP-------GRTRTDKVQPEAKTPTYGSLAAKLMCSSTGQTDES--------------------------------- ------------------------- >Ciona_intestinalis_NIPAL2 -------------------------------------------------------------------------------- ---------------MAHHV--------------------------------------IGMTLAISGNLLISVSLSVQKK AHNRLGHHSQAK---------YCMDKWWWT--GMLL---MVLGELGNFMAYGFAPASLVAPLGSVAVLA---NAVIAVVF LREPLTTSSMMG--------VTLVLMGSLTLISFSAKTRPTLSSEQIMEYLKAWT--FLLYIGIE--------AIVLIVL LF-IKYVRKNEHLVILLLLVGIIAS--VTVIASKAISTMISESIFQN---KLQIMNVVF-WVCLVILPITTATQIRLLNR AMQLYDV-SDVVPVNFMFFTVSAVLA-----GAIFYKEFEGVAFDRVFMFIFGCLLSFAGVYIIS--------------- -------------------------------------------------------------------------------- ------------------------- >Ciona_savignyi_NIPAL2 -------------------------------------------------------------------------------- -----------MIGINVTSTPGAHYSSATNATSHFS-FNPYS----------------LGTALAVIGNTLIAVSLNVQKY AHRKRETQEEEEESSLCGPNSYLRSYTWWV--GIVL---MAVGEVGNFVAYGFAPASVVAPLGCVAVLV---NGGLAMVF NNESLRMRDVVG--------ASFAIVGSFLVVTFSSKPKLILNAQELIAHLGGWQ--FIIYMFLE--------IVMFGII IF-IKS-QDVKNVFIHLSLVAILGS--FTVISAKAVSGLLALTLEG----KSQLGEPIL-YIMVVIMIGTTLFQVKYLNA AMRLYDI-ATVVPINFVLFTISAILA-----GTLFYQELSREPGINILMFIFGCLLSFMGVIFIAGDKGERGDPHEAGAL HLDMMPNFVRYLAPSFLTTEVQPVRNDHQSKCYPDHEPGCSSGSDGSEGTEGTYDADYTQHNSTLDTET----------- ------------------------- >Nematostella_vectensis_NIPAL2 -------------------------------------------------------------------------------- -----------------------------------------F----------------VGSALAICGNLLISVSMNIQKY SHIQQ--------EKSNNETHYLKSKVWWC--GLIL---MVLGEVGNFSAYGFAPASLVAPLGTTTVIA---NAVIAVVF LKEKIRYQDVFG--------VLLAIVGAFLLITFSTKDYAELTGQELAFYMKQWP--FLFYLVIE--------IVTFCVL LY-VQMRYNLENVVVFLLLVALLGS--LTVISAKAVSSMINITLGG----DNQLGYPLL-YIMLIVMVTTAIAQVKFLNR AMKSFDA-TVVVPTNFVLFTISAIIS-----GIVLYREFYGLTFLEIFMFLFGCVLSFIGVYYITSDRK----------- -------------------------------------------------------------------------------- ------------------------- >Hydra_magnipapillata_NIPAL2 -------------------------------------------------------------------------------- --------------MNGTTTN---PLSTSAVPPTFPRNERIL----------------LGVVLAITGNLLISVSMNIQKY SHN-----------KLIPGTSYIKSLTWWG--GIIL---MAIGEVGNFSAYAFAPASLVAPLGTTTVIA---NAVIAVVF LKEKIRYRDVLG--------IVLAIVGAFLLITFSNKNDTMLSAQEILVYIKQWS--FLVYMGLE--------IVAFIVF LF-WDKYYEVGKIIVILLQVAILGS--FTVITAKAVSSMLTITFRG----YSQLNQPIF-YIMFAIMVATAVAQVRFLSK AMSLFDT-TMVVPTNFVFFTMSAIIG-----GIVFYREFYGLLFLDIFMFLFGAFLSFGGVYLITAERKKVDVPSSEDEN VVLIP-------------CTPTITTNDLVATSLQLHEVYDNPALLGFDGIEEKSDFVTS--------------------- ------------------------- >Homo_sapiens_NIPAL3 -------------------------------------------------------------------------------- ---------------MDGSHSAALKLQQLPPTSSSSAVS---------EASFSYKENLIGALLAIFGHLVVSIALNLQKY CHIRL--------AGSKDPRAYFKTKTWWL--GLFL---MLLGELGVFASYAFAPLSLIVPLSAVSVIA---SAIIGIIF IKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWP--FLLYMLVE--------IILFCLL LYFYKEK-NANNIVVILLLVALLGS--MTVVTVKAVAGMLVLSIQG----NLQLDYPIF-YVMFVCMVATAVYQAAFLSQ ASQMYDS-SLIASVGYILSTTIAITA-----GAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNR-KKPIPFEPYIS MDAMP--GMQNMHDKGMTVQPELKASFSYGALENNDNISEIYAPATLPVMQEEHGSRSASGVPYRVLEHTKKE------- ------------------------- >Pan_troglodytes_NIPAL3 -------------------------------------------------------------------------------- ---------------MDGSHSAALQLQQLPPTSSSSAVS---------EASFSYKENLIGALLAIFGHLVVSIALNLQKY CHIRL--------AGSKDSRAYFKTKTWWL--GLFL---MLLGELGVFTSYAFAPLSLIVPLSAVSVIA---SAIIGIIF IKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWP--FLLYMLVE--------IILFCLL LYFYKEK-NANNIVVILLLVALLGS--MTVVTVKAVAGMLVLSIQG----NLQLDYPIF-YVMFVCMVATAVYQAAFLSQ ASQMYDS-SLIASVGYILSTTIAITA-----GAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNR-KKPIPFEPYIS MDAMP--GMQNMHDKGMTVQPELKASFSYGALENNDNISEIYAPATLPVMQEEHGSRSASGVPYRVLEHTKKE------- ------------------------- >Mus_musculus_NIPAL3 -------------------------------------------------------------------------------- ---------------MDGAHSAGLQLQPLPPTSGATSTSLSS-----SEGSFSYKENLIGALLAIFGHLVVSIALNLQKY CHIRL--------AGSKDPRAYFKTKTWWL--GLLL---LLLGELGVFASYAFAPLSLIVPLSAVSVIA---SAIIGIIF IKEKWKPKDFVRRYVLSFVGCGLAIVGTYLLVTFAPNSHEKMTGENIARHLVSWP--FLLYMLVA--------IVLFCLL LYFYKER-NANSIVVILLLVALLGS--MTVVTVKAVSGMLVLSIQG----NLQLDYPIF-YVMFVCMVATAIYQATFLSE ASQIYDS-SLIASVGYILSTTAAITA-----GAIFYLDFLGEEALHICMFALGCLIAFLGVFLITRNR-KKAIPFEPYIS MDAMP--GMQDMHAKGTTVQPDLKASFSYGALESNDSISELYTPATLPVMQEEHSSRSTPGVPYRVLEHTKKE------- ------------------------- >Rattus_norvegicus_NIPAL3 -------------------------------------------------------------------------------- ---------------MDGAHSAGLQLQPLSPTSGATSPSLSS-----GEGSFSYKENLIGALLAIFGHLVVSIALNLQKY CHIRL--------AGSKDPRAYFKTKTWWL--GLLL---LLLGELGVFASYAFAPLSLIVPLSAVSVIA---SAIIGIIF IKEKWKPKDFVRRYVLSFVGCGLAIVGTYLLVTFAPNSHEKMTGENIARHLVSWP--FLLYMLVA--------IVLFCLL LYFYKEK-NANSIVVILLLVALLGS--MTVVTVKAVAGMLVLSIQG----NLQLDYPIF-YVMFVCMVATAIYQATFLSQ ASQIYDS-SLIASVGYILSTTVAITA-----GSIFYLDFLGEEALHICMFALGCLIAFLGVFLITRNR-KKAIPFEPYIS MDAMP--GMQDMHAKGMTVQPDLKASFSYGALENNDSISEIYTPATLPVMQEEHSSRSTPGVPYRVLEHTKKE------- ------------------------- >Gallus_gallus_NIPAL3 -------------------------------------------------------------------------------- ---------------MEGGNSPNMQLQQIPLATAAVSVQP-------HTDSFSYKENLIGALLAIFGHLVISIALNLQKY SHIRL--------AGSKDSRAYFKTKTWWC--GLFL---LVLGELGVFSSYAFAPLSLIVPLSAVSVIA---SAIIGIIF IKEKWKPKEFLRRYVLSFVGCGLAIVGTYLLITFGPNSHEKMTGENITRHLVSWP--FLLYMLVE--------IIIFCLL LYFYKEK-NANYIVIILLLVALLGS--MTVVTVKAVAGMIVVSIRG----NLQLNYPIF-YIMLVCMIATAVFQATFLAQ ASQLYDS-SQIASIGYILSTTVAITA-----GATFYLDFTGEDVLHICMFALGCLIAFLGVFLITRNR-KKSVPFEPYIS MDAMP--GMQNMHDKGIAVQPDLKASFSYGALENNDNMPEIYTPATLPIVQEQHGSRGVSAPPYRVLEHSKKE------- ------------------------- >Danio_rerio_NIPAL3_a -------------------------------------------------------------------------------- -----------------------MNSVSMAQKDGMLADS--------------YTDNLIGTLLAIFGNLLVSISVSIQKQ SHVTL--------AGNKDPRQYYYTKTWLL--GLVL---MVLGEGALFVSYAFAPLSLIAPLNAVSVIS---SSILGFLF LREKWKAQEFLKRYILTFLGCAMTAGGTYLFVTFGPNSHEKLNAENIVKHVISWP--FLLYLLLG--------IIAFCLV LYYYKQR-NANYLVLILLLVALLGS--VTVITVKAVSGMIVLSIVG----PLQLSYPIF-YVMFVCMVATIVFQASFLAQ ASHLYDS-SLIACVNYIFCTTFAIGG-----GAVFYQEFNHEDVLHICLFLLGCAICFLGVFLITKNK-RKAKSFEPYVT MDMA--KGIPTIHNKGWAVQPDYNGSFSYGALENNDSV----APVTLPVNHEQSVSPGPVSSYQPSELKKD--------- ------------------------- >Danio_rerio_NIPAL2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------MFE--------ALLFAIL MYLYKCR-NVKHIIIMMILVALLAS--VTVISVKAVSGMITETLRGS---HLQLTYPIF-YIMFIIMITSCAFQIKFLNE AMKLFDA-TEIVPINYVFFTASAVVA-----GILFYEEFYGISLVHVLMFGVGCLLAFTGVFLIARARPRIK-MDSVFIS MEQMP-------G-----KCVCVCVCVCIVSVC----------------------------------------------- ------------------------- >Takifugu_rubripes_NIPAL3_a -------------------------------------------------------------------------------- ----------------------------MDSS-HSDAGS--------------YTDNLIGTLLAIFGNVLVSISLCIQKY SHLKL--------AGAKDPRTFYRTKTWWC--GFIL---TCLGEGANFVSYAFAPLSLIAPLNAVSIVA---SSILGLLF LLEKSKTKDFLKRYGLSFFGCVLTIGAIYLFVTFGPNSHEQLKAENIVKHVVAWP--VLLYLLVE--------IITFCLL LYFYKQH-RANYLIVIVLLVSLLSS--VTVITVKALSSMLVLTVRG----TMQLNYPIF-SVMLVCMVASIVFQARFLSQ ACKLFEP-SLIASVNYILSTFFAIVA-----GAVFYLEFKSEDVLHICLFLLGSALCFLGVFLITKNR-KNPQTFEPFVT MDMASAKGVPTIHDKG---LVDFNGSFSYGTLVNADGV----ARTTLPVKLDQPPIRSRS-------------------- ------------------------- >Tetraodon_nigroviridis_NIPAL3_a -------------------------------------------------------------------------------- ----------YNNSHRLRIKRQRLKTITMDSS-QTDIDS--------------YTENLIGTLLAIFGNALVSISLCIQKY SHMRL--------AGAKDPRPFYCTKTWWC--GFVL---TVLGEGANFVSYAFAPLSLIAPLNAVSIVA---SSILGLIF LLEKSRPKSFAKNYGLSFFGCVLTIGAIYLFVTFGPNSHEQLKAENIVKHVVAWP--VLLYLLVE--------IVAFCLL FYFYKTH-HANYLIISLLLVSLLGS--VTGITVKAVSSMLVLTVKG----TMQLNYPIF-SVMFVCMVASVAFQARFLSQ ACKLYEP-SLIASVNYILTTSLAIVA-----GAVFYLEFKNEDVLHICLFLLGSAFCFLGVFLITKNR-KNPQTFEPFVT MDM---KGVPTIHDKG---LVDFNGSFTYGTLVNEDGV----AQ------------------------------------ ------------------------- >Gasterosteus_aculeatus_NIPAL3_a -------------------------------------------------------------------------------- ---------------------------MMFLY-GAYGGS--------------YTDNLIGTLLSIFGNVLVSISLSIQKY SHVKS--------AGAKDVRVFYHTKTWWS--GFVL---ICLGEGANFVSYAFAPLALITTLNAVSVLT---SSILGLIF LREKLRPKAFAKRYGLSFLGSILISGGTFLFVVFGPNSHEKLKAENIVTHLVGWP--VLLYMLLE--------IVTFCLL LYFYKQR-NANYLVVILMLVALLNS--VTVITVKAVSGMLVLSIEG----SMQLDYPIF-SVMFVCMVASVVFQARFLSQ ACNLYDS-SLIAGVNYILSTVSAVVA-----GAVFYVEFKNEDVLHVCMFLLGSAFCFLGVFLISKNR-KRTKTFEPYVT MDMVNASGVPTIHDRGLFVQPDSNGTFSYGALVNNDGA----APVTLPVDPEQPPVASMRIDPPSGRRD----------- ------------------------- >Oryzias_latipes_NIPAL3_a -------------------------------------------------------------------------------- -------------------------GEKMGFY-SSHGES--------------YTDNLIGTLLAIFGNFLVSISLSIQKY SHVTL--------AGRKDQRTFYHTKTWWC--GFVF---TCIGESANFVSYAFAPLAVVAPLNAVSVLT---SSILGFLF LHEKSKPKEFAKHYGLIILGYFITAGGTYLFVSFGPNSHEKLEAENIIKHIVGWP--VLLYLLLE--------IILFCLL LYFHKQR-RVNYLVVILLLVALLGS--VTVITVKAVSGMLVLSIEG----NIQLDNPIF-SVMFVCMMASVIFQARFLSQ ACKLHDS-SLVMSVNYILSTVFAVVA-----GAVFYLEFNKEEVLNICMYVLGSVLCFLGVFLMTKNR-KKPKIFEPYVS MDMSN--GVPTIHDKGSVVQPDFNGSFSYGTLVNNDGV----APAPLPVNLEQPVVSSRTSDAPTGQLDRKND------- ------------------------- >Homo_sapiens_NIPAL4 MPGDSSPGTLPLWDASLSPPLGPDPGGFSRASHAGDKSRPPAPELGSPGAVRPRVGSCAPGPMELRVSN--TSCENGSLL HLYCS--SQEVLCQIVNDLSPEVPSNATFH---------------SWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKK GLLRLVATGATRAV--DGGFGYLKDAMWWA--GFLT---MAAGEVANFGAYAFAPATVVTPLGALSVLIS---AILSSYF LRESLNLLG--------KLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDT--GFIVFAVLL--------LVSCLIL IFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLP-----VVRHPLPYILSLILAL--SLSTQVNFLNR ALDIFNT-SLVFPIYYVFFTTVVVTSS-----IILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASL-PH MHKNP-PP------SPAPEPTV----IRLEDKNV-------------LVDNIELASTSSPEE-KPKVFIIHS-------- ------------------------- >Pan_troglodytes_NIPAL4 ----------PLWDASLSPPLGPDPGGFSRASHAGNKSRPPAPELGSPGAVRPRVGSCAPGPMELRVSN--TSCENGSLL HLYCS--SQEVLCQIVNDLSPEVPSNATFH---------------SWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKK GLLRLVATGATRAV--DGGFGYLKDAMWWA--GFLT---MAAGEVANFGAYAFAPATVVTPLGALSVLIS---AILSSYF LGESLNLLG--------KLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDT--GFIVFAVLL--------LVSCLIL IFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLP-----VVRHPLPYILSLILAL--SLSTQVNFLNR ALDIFNT-SLVFPIYYVFFTTVVVTSS-----IILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASL-PH MHKNP-PP------SPAPEPTV----IRLEDKNV-------------LVDNIELASTSSPEE-KPKVFIIHS-------- ------------------------- >Mus_musculus_NIPAL4 --------------------------------------------------------------MELRVANANGSCENGSIV SLYCS--SQEVLCQIVRGISPEEPYNATLI---------------TWQERVRKKYGFYIGVGLAFLSCFLIGTSVILKKK GLIRLVATGATRAV--NGGYGYLKDPMWWA--GMAT---MSAGEVANFGAYAFAPATVVTPLGALSVLIS---AIFSSYC LGESLNLLG--------KLGCVICMAGSTVMVIHAPKEEKVTTVAEMASKMKDT--GFIVFAVLL--------VVSCLIL IFIVAPRYGQRNILIYIIICSVIGSFSVTAVKGLGVTIRNFFQGLP-----VVRHPLPYILSLILGL--SIIIQVNFLNR ALDIFNT-SLVFPIYYVFFTTVVVASS-----IVLFKEWYTMSAVDIVGTLSGFVTIILGVFMLHAFKDLDINQISL-PH THKNP-TP------APAPEPTV----IKLEDKNV-------------LVDNIELASTPSPQQ-KPKVFMTDS-------- ------------------------- >Monodelphis_domestica_NIPAL4 ------------------------------------------METLGSNSSC----------------------ANGSLI TLYCY--SQQVLCQIVSDFEPDSSNNITLS---------------SWQKRATKNYGFFIGVGLAILSSFLIGSSVILKKK GLVRLVDKGATRAV--DGGFGYLLDKMWWA--GFLT---MALGEAANFGAYIFAPATVVTPLGALSVLIS---AILSSYF LGERLNLLG--------KLGCMIAIAGSSVMVIHAPEEEKVNSINEMASKLKDT--GFIVFAVLL--------LVSSLIL IFIIAPRYGQKNILVYIIICSVMGSYSVCAVKGMGIAIKGFFKGQP-----VLRHPLTYCLGLILAT--SIPIQVNFLNR ALDIYNT-SLVFPIYYVTFTSTVITSS-----IILFKEWNSMSVVDILGTISGFITIILGVFLLYAFKDLDITWESL-PH THKNP-IP------PPTPEPTI----IKLEDKNV-------------LVDNIELP-PPSPEE-KPKVFTIHT-------- ------------------------- >Ornithorhynchus_anatinus_NIPAL4 ---------------------------------MPAPKPTLPGKSFQVSSHCPARGTVICGPLRSALCFGAIPSINSSLL TLHCS--SQQVLCQIIGELGLEASDNATSS---------------SWQEKAKRNYGFFIGLGLAVFSSFLIGSSVILKKK GLLRLVAKGATRAV--DGGYGYLKDSMWWA--GLLT---MAAGEAANFGAYAFAPATVVTPLGALSVLIS---AILSSYF LGEGLNLLG--------KLGCAICVAGSTVMVIHAPEEEMVTTLDEMVSKLKDT--GYIVFAVLN--------LVTCLIL IFFIAPRYGQKNILIYIIICSGIGAFSVSAVKGLGIAIKGFFQHQP-----VLQHPLSYILVLILAA--SLSTQVNFLNR ALDVFNT-SLVFPIYYVFFTTMVITSS-----IILFKEWTTMTAMNVVGTISGFVTIILGVFLLHAFKDLSISWSNL-PH THTDP-TP------PPDPEPIV----IKLEDKGI-------------LVDNMEMP-IPLPEE-KPKVYIVNG-------- ------------------------- >Gallus_gallus_NIPAL4 ------------------------------------------------------------MMMEPLAAN--SSCSNGSLL SISCL--SHQVVCQVVGGADLADPVHDNGTG------------DTSWVTQLESNYGFYIGLGLAVFSSFLIGSSIILKKK GLLRLVEKGGTRAG--DGGHGYLKDWLWWA--GLLT---MGGGEAANFAAYAFAPATIVTPLGALSVLI--S-AILSSYL LGERLNLLG--------KLGCMLSLVGSTVMVIHAPEEEEVTTLDEMLFKLKEP--GFLAYAVVL--------LAICFLL ILYLAPRYGRSNILIYLTICSVIGAFSVSSVKGLGIAIKGFFAGQP-----VLQHPLTWILVITLVA--SITTQINYLNK ALDIFNT-SLVFPIYYVLFTTIVITTS-----IILFKEWVAMTVVDIIGTVCGFLTIILGVFLLHAFKDMDVNLGNL-PQ VLQSE-----------QEAPVI----R--DDKNI-------------LIE-VDNSSIAPED--KSKALA----------- ------------------------- >Danio_rerio_NIPAL4_a ---------------------------------------------------------MGVTMKDIHLPS--DSCINGSVI RIFCP--TSASICVFDTAVGNTSYSLDNSNKNLT-------VSTQSLAIDKWSNYNFWTGLTLAVLSAFLIGGSVILKKK ALLRLANTGETRAA--EGGHGYLKDWLWWG--GLLT---MGGGEAANFAAYMFAPATVVTPLGALSVLIS---AVLSSHL FRETMNLLG--------KLGCMLSVLGSTLMVIHAPEEEEVTTLKEMAEKLLDP--GFLVFASIL--------LVTCLIL IFYVSPRFGQSNILVYISICSLLGSFTVSSVKGLGIAIRTMFTDTS-----VVRNPLMWILLLTLIG--SIIIQVNYLNK SLDTFNT-LLVYPIYYVFFTTVVLSTS-----VILFKEWGAMSGVDVVGTIGAFLVIVIGVSMLNIFKDLNVCFEDLRSN LCQ--PLS------QESPSKR--------EDKHI-------------LIEN--IETLPPMREEGPRVFIIS--------- ------------------------- >Takifugu_rubripes_NIPAL4_a ----------------------------------------------------------------VQLHN--ETCVNGSVV RLWCG--SQSTVCVITGET--VVYSSLNNN-------------TQTTELQTTRSYKLWLGLTLALLSAFLIGGSVILKKK ALLRLATSGHTRAG--DGGHGYLKDWLWWG--GLLT---MGAGEACNFAAYMFAPATLVTPLGALSVLIS---AVLSSYL LGETLNIMG--------KLGCLLCLLGSILLVIHAPQEQEVTSLQDMTNKLLEP--GFLVYMSVV--------LVLCGVL VLYLCPRLGQSNILIYISICSLLGAFTVSSVKGLAIAIDTVLYDVS-----VLANPLTWILLLTLIV--SVVTQVNYLNK SLDTFNT-LLVYPIYYVLFTSVVLSTS-----IILFQEWRSMAAVDVVTTLGAFVVIVVGVAMLHLFREMQLSAPGAGPQ LNQEAPPT------QQAEGRRR----KKKEDKHG-------------LMDNMVIESLPPMREEGPRVFIIST-------- ------------------------- >Homo_sapiens_NIPA1 -------------------------------------------------------------------------------- -----------------------------MGTAAAAAAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGSTFVLQKK GIVRAKR----------RGTSYLTDIVWWA--GTIA---MAVGQIGNFLAYTAVPTVLVTPLGALGVPFG---SILASYL LKEKLNILG--------KLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNP--VFVGYLCIV--------LLMLLLL IFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPS----SQ-RALCLCLVLLAVLGCSIIVQFRYINK ALECFDS-SVFGAIYYVVFTTLVLLAS-----AILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKS NMKTD--------------------------------------------------------------------------- ------------------------- >Mus_musculus_NIPA1 -------------------------------------------------------------------------------- ----------------------------------MGTAAAAAAAG-EGARGPSPAAVSLGLGVAVVSSLVNGSTFVLQKK GIVRAKR----------RGTSYLTDIVWWA--GTIA---MAVGQIGNFLAYTAVPTVLVTPLGALGVPFG---SILASYL LKEKLNILG--------KLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNP--VFVGYLCIV--------LLMLLLL IFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPS----SQ-RALCLCLVLLAVLGCSIIVQFRYINK ALECFDS-SVFGAIYYVVFTTLVLLAS-----AILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKS NMKTD--------------------------------------------------------------------------- ------------------------- >Rattus_norvegicus_NIPA1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------GTSYLTDIVWWA--GTIA---MAVGQIGNFLAYTAVPTVLVTPLGALGVPFG---SILASYL LKEKLNILG--------KLGCLLSCAGSVVLIIHSPKSESVTSQAELEEKLTNP--VFVGYLCIV--------LLMLLLL IFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPS----SQ-RALCLCLVLLAVLGCSIIVQFRYINK ALECFDS-SVFGAIYYVVFTTLVLLAS-----AILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKS NMKTD--------------------------------------------------------------------------- ------------------------- >Danio_rerio_NIPA1_a -------------------------------------------------------------------------------- --------------------------------------------------MDETPFPVVGVVIAVVSSFINGSTFVLQKK GILRARK----------SGGTYLADCVWWC--GTLA---MIVGQIGNFLAYNVAPAVVVTPLGALGVLFG---AVLASWL LQEHLDLIG--------KLGCILCCCGAVVLIIHSPKSENVTSRAELEERLMDP--VFQVYISLV--------VILLIIL IGWLSPAHGKSNIMVYVGICSLLGSFTVPSSKGLGLAAQEAFSQTPS----SDGRAFFLFLGLLGVLVVSILIQFTFINK ALENFSS-NMFEAIYYVTFTSCVILAS-----AVLFREWTALGIVDCLGILCGFVTVSVGVALLRISQEAKLTWSQTKDK EN------------------------------------------------------------------------------ ------------------------- >Takifugu_rubripes_NIPA1_a -------------------------------------------------------------------------------- -----------------------------------------------------------GILIAVVASFINGSTFVLQRK GILRSRE----------KGRSYLTDVFWWT--GTLS---MAVGQIGNFLAYNVAPAVIVTPLGALGVLFG---ALLASWI LKEHLNLLG--------KLGCVLCCSGSVMLVVHAPRAEAVTSRTEFEERLLDP--VFVAYALLV--------LLLLLVL IVWVAPAHGSSNIMVYICICSLLGSFTVPSSKGLGLVAKDVLAEGPP----SS-RALALFLALLAVLATSILTQFLFINK ALERFSS-NTFEAIYYVTFTSSVILAS-----ALLFKEWTALNVAGCLSMVCGLATTCVGVVLLRISQE----------- -------------------------------------------------------------------------------- ------------------------- >Tetraodon_nigroviridis_NIPA1_a -------------------------------------------------------------------------------- -----------------------------------------------------------GILIAVAASFINGSTFVLQRK GILRSRE----------RGRSYLTDVVWWT--GTLSTITVAIGQIGNFLAYNFAPAVVVTPLGALGVLFG---ALLASWI LKERLNFLG--------KLGCVLCCSGSVVLILHAPKAEAVTSRTEFEERLLDP--VFVSYVLLV--------LLLLLVL IVRIAPAHGSSNIMVYVCICSLLGSFTVPSSKGLGLVAPDVLG-GPP----SG-RALALFLALLAVLAASVLTQFLFLTK ALQRFGS-STFEAIYYVTFTSSVLLAS-----ALLFREWTSLELPDGLALLCGLATSSVGVLLLRLSQE----------- -------------------------------------------------------------------------------- ------------------------- >Gasterosteus_aculeatus_NIPA1_a -------------------------------------------------------------------------------- --------------------------------------------------QTSVSFPVSGVVIAVVSSCINGSTFVLQKK GILRSRD----------RGCSYLTDVVWWS--GTLA---MIIGQIGNFLAYNVAPAVIVTPLGALGVLFG---AVLASRV LGEQLNILG--------KLGCVLCCCGSVVLVMHAPKAAAVTSRLELEAGLSDP--VFVAYGLLL--------VLLLLVL IAWIAPAHGSSNVMVYVAICSLLGSFTVPSSKGLGLVAPGVLG-AEP----G---ALPLFLGLLATLAVSVLLQFFFINK ALERFSS-NVFEAIYYVAFTSSATVAS-----GLLFKEWTALTAAGAAAMLCGLTTVCVGVVLLRISQEASVTWRTTKKT E------------------------------------------------------------------------------- ------------------------- >Oryzias_latipes_NIPA1_a -------------------------------------------------------------------------------- --------------------------------------------MADGSELPVASSETAGIVIAVLSSFVNGCTFVLQKK GILRSRE----------KGVSYVTDLVWWS--GTLC---MIIGQIGNFLAYNVAPVVIVTPLGALGVLFG---AVLASWI LEEHLNILG--------KLGCLLCCCGSIVLIIHSPKAEAT-SRAEFEERLFDP--VFVTYILLV--------VVLLIVL IVWIVPAHGTSNILVYVSICSLLGNFTVPCSKGLGLVAPDAFGGGAA----SG-EALALLLGLLGTLAVSILTQFYFINK ALECFSS-NIFDAIYYVAFTSSVIFAS-----AILFKEWTALAVTDCLAMLCSLTVVCVGVVLLRISQAALISWRKEPTK DKMN---------------------------------------------------------------------------- ------------------------- >Homo_sapiens_NIPA2 -------------------------------------------------------------------------------- -----------------------------------------------MSQGRGKYDFYIGLGLAMSSSIFIGGSFILKKK GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---MGAGEVANFAAYAFAPATLVTPLGALSVLVS---AILSSYF LNERLNLHG--------KIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDP--GFVVFATLV--------VIVALIL IFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKP-----VLRHPLAWILLLSLIV--CVSTQINYLNR ALDIFNT-SIVTPIYYVFFTTSVLTCS-----AILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVS FRKDEK-------AMNGNLSN---MYEVLNNNEE------------SLTCGIEQHTGEN-VSRRNGNLTAF--------- ------------------------- >Pan_troglodytes_NIPA2 -------------------------------------------------------------------------------- -----------------------------------------------MSQGRGKYDFYIGLGLAMSSSIFIGGSFILKKK GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---M---------------------------LVS---AILSSYF LNERLNLHG--------KIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDP--GFVVFATLV--------VIVALIL IFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKP-----VLRHPLAWILLLSLIV--CVSTQINYLNR ALDIFNT-SIVTPIYYVFFTTSVLTCS-----AILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVS FRKDEK-------AMNGNLSN---MYEVLNN-DE------------SLTCGIEQHTGEN-VSRRNGNLTAF--------- ------------------------- >Mus_musculus_NIPA2 -------------------------------------------------------------------------------- -----------------------------------------------MSLGRGKYDFYIGLGLAMTSSIFIGGSFILKKK GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---MGAGEVANFAAYAFAPATLVTPLGALSVLVS---AILSSYF LNERLNLHG--------KIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDP--GFVVFATFV--------VIVALIF IFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELLAGKP-----VLQHPLAWILLFSLVV--CVSTQINYLNR ALDIFNT-SIVTPIYYVFFTTSVLTCS-----AILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVS FRKDEK-------AMNGNLSS---MYEVLNNNED------------DLPCGIE-HTGEN-ISRRNGNLPSF--------- ------------------------- >Rattus_norvegicus_NIPA2 -------------------------------------------------------------------------------- -----------------------------------------------MSLGRGKYDFYIGLGLAMTSSIFIGGSFILKKK GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---MGAGEVANFAAYAFAPATLVTPLGALSVLVS---AILSSYF LNERLNLHG--------KIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDP--GFVVFATFV--------VIVALIF IFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGITIKELLAGKP-----VLQHPLAWILLLSLVV--CVSTQINYLNR ALDIFNT-SIVTPIYYVFFTTSVLTCS-----AILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVT FRKDEK-------AVNGNLSN---MYEVLNNNEE------------DLPCGIE-HTGEN-ISRRNGNLTSF--------- ------------------------- >Danio_rerio_NIPA2_a -------------------------------------------------------------------------------- -----------------------------------------------MGQDRGKYDFYIGLALAISSSIFIGGSFILKKK GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLV--S-AVLSSYF LTERLNLHG--------KLGCLLSILGSTTMVIHAPQEEEIDSLKDMAKKLVDP--GFVVFATAV--------IIIALIF IFVLGPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKEAIAGKP-----VLRNPLAWLLLLSLIA--CVSTQINYLNK ALDIFNT-SLVTPIYYVFFTTSVLSCS-----AILFKEWEHMGVDDIIGTLSGFVTIIVGIFLLHAFKDVSISLATLAVS IRKDERNGPV----SNGMAAHNHSNYELLRNEVT------------EDFEDREPGLPFDSVSRRNGTMTVS--------- ------------------------- >Danio_rerio_NIPA2_b -------------------------------------------------------------------------------- ------------------------------------------------MDVANRSDFYIGLALAVSSTIFIGGSFILKKK GLLRLASKGSTRA--GQGGYAYLKEWLWWA--GLIS---MGIGEAANFAAYAFAPATLVTPLGALSVLVS---AVLSSYF LSERLNIHG--------KIGCLLCIFGSTVMVLHAPQEEEVASLSAMAEKLKDP--GFIAFAVCI--------VVSSLVL IIFVAPRYGQKNVLVYILICSVIGSLSVSCVKGLGIGIKELFGGTA-----VLKDPLFWALLICLVV--CISIQISYLNK ALDIFNT-SIVTPIYYVFFTTSVMACS-----AILFKEWLRMSTDGAAGTVSGFLTIIIGIFLLHAFKDINFSLDSLPLY LHHGLRG--------HAYVALP--TDERIDESSL-------------TKERSATFFPDSSDKRSNGTFIA---------- ------------------------- >Takifugu_rubripes_NIPA2_a -------------------------------------------------------------------------------- -----------------------------------------------MGQDRGKYDFYVGLALAVSSSIFIGGSFILKKK GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLV--S-AVLSSYF LTERLNLHG--------KLGCLLSILGSTTMVIHAPQEEEITSLEDMAEKLVDP--GFCVFATLV--------IIVALIF IFVVGPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKEAIAGKN-----VVGNPLAWILLLGLVA--CVSTQINYLNK ALDIFNT-SLVTPIYYVFFTTSVLTCS-----AILFKEWGHMGSDDVIGTLSGFSTIIIGIFLLHAFKDISVSLANLAVS MRKEERAFPT----ANGLGSHST--YEMLH-ESN------------EDMEDRDMGSSFDSVSRRNGAMTSL--------- ------------------------- >Tetraodon_nigroviridis_NIPA2_a -------------------------------------------------------------------------------- -----------------------------------------------MGQDRGKYDFYVGLALAVSSSIFIGGSFILKKK GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---MGAGEGANFAAYAFAPATLVTPLGALSVLV--S-AVLSSYF LTERLNLHG--------KLGCLLSVLGSTTMVIHAPQEEEITSLEDMAHKLVDP--GFCVFATLV--------IIVALIF IFVVGPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKEAIAGKK-----VASHPLAWVLVLGLVA--CVSTQINYLNK ALDIFNT-SLVTPIYYVFFTTSVLLCS-----AILFKEWGHMGPDDVIGTLSGFLTIIIGIFLLHAFKDVSVSLANLAVS MRKEERAFPA---NANGLAAHAT--YKVLRNESG------------EEAEERE--------------------------- ------------------------- >Tetraodon_nigroviridis_NIPA2_b -------------------------------------------------------------------------------- ------------------------------------------------MEV-NRLDFYIGLALAVSSSVFIGASFILKKK GLLRLARKGSTRA--GQGGHAYLKEWLWWA--GLIS---MGIGEAANFAAYIFAPATLVTPLGALSVLVS---AVFSSYF LNERLNIHG--------KVGCLLSILGSTVMVIHAPQEEEVGSLDAMADKLKDP--GFIVFAACV--------VGSSLLL IFAVAPRFGQKNVLVYILICSVVGSLSVSCAKGLGIGIKELFAGEA-----VLKHPLFWSLLICLVI--CLSVQINYLNK ALDIFNT-SIVTPIYYVFFTTSVMTCS-----AILFKEWLNMSVDGIVGTLSGFFTIVLGIFLLHAFKDIPFTWDSLPVF IRKGPQGFPW---GHQSYTALP--NPNPLVENEV-------------KLPRDGSTTGGLSPDHRSQ-------------- ------------------------- >Gasterosteus_aculeatus_NIPA2_a -------------------------------------------------------------------------------- -----------------------------------------------MGQDRGKYDFYLGLGLAVSSSIFIGGSFILKKK GLLRLARKGSTRA--GQGGHAYLKEWLWWA--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLV--S-AVLSSHF LTERLNLHG--------KLGCVLSILGSTTMVIHAPKEEEISSLEHMAEKLVDP--GFFIFATLV--------IIVALIF IFVVAPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKEAVAGHS-----VASNPLSWILLLGLVA--CVSTQINYLNK ALDIFNT-SLVTPIYYVFFTTSVLSCS-----AILFKEWGHMGAADVIGTLSGFLTIIVGIFLLHAFKDVSVSLASLAVS MRKEERPSPA---AANGTASH----YELLL--RG------------ESPEDMEMGPPFESVSRRNGAMTL---------- ------------------------- >Oryzias_latipes_NIPA2_a -------------------------------------------------------------------------------- -----------------------------------------------MGQDRGKYDFYIGLGLAISSSIFIGGSFILKKK GLLRLAKKGSTRA--GQGGHAYLKEWLWWA--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLVRCS-AVLSSYF LTERLNLHG--------KLGCMLSILGSTTMVIHAPKEEEISSLEHMSKKLVDPATGFVVFATLV--------VIVALIF IFVVGPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKEAIAGTN-----VVKNPLAWVLLFSLVG--CVSTQINYLNK ALDIFNT-SLVTPIYYVFFTTSVLTCS-----AILFKEWEHMGADDVIGTLSGFITIIVGIFLLHAFKDLNVSLAALAVS MRKDDRPFPV-----NGVTSHST--YELVHEEST------------EDMEEREMGPPFDTISRRNGSMAS---------- ------------------------- >Oryzias_latipes_NIPA2_b -------------------------------------------------------------------------------- ------------------------------------------------MEG-NRVNFYIGLSLAVSSSAFIGASFILKKK GLLRLASKGSMRA--GQGGHAYLKEWLWWA--GLIS---MGVGEAANFAAYAFAPATLVTPLGALSVLVS---AVLSTYF LNEQLNIHG--------KVGCLLCILGSTVMVIHAPQEEEVGSLTAMAEKLKDP--GFIVFAVCV--------VGSSLVL IFAVAPRFGQKNVLVYILICSVIGSLSVSCVKGLGIGIKELFSGTA-----VLKEPLFWSLVICLVI--CVSVQINYLNR ALDIFNT-SIVTPIYYVFFTTSVMACS-----AILFKEWLRMTADGVVGTISGFLTIILGIFLLHAFKDIPFHWNSLPLY LQKDPRDFSR---GQQPYETLS--SRDLETEGEA-------------GLSKSGRLNGGWRQHQSTA-------------- ------------------------- >Ciona_intestinalis_NIPA2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------MGEKLRDP--IFVTYAVAV--------LLVSLYL IFYVAPRHGTSNVMVYISICSLLGSFSVSCVKGVGMVFKGFAAGDN-----VWIKPLTYVLIIGLVL--SVSTQVNYLNK ALDVFNT-SMVTPVYYVLFTTTVLTCS-----AILFKEWNDMDARSVIGMLAGFGTIVTGIFFLHAFKDINFSLNDL-PK FSKNGASD---QSVHYTTMMRN----H-TDERRE-------------LLDEVDLTMYSEDDEENSAVLFNKKPKDTLQNG RIQR--------------------- >Ciona_savignyi_NIPA2 -------------------------------------------------------------------------------- --------------------------------------------------VAYGGGFYIGLGLAVSSSIFIGGSFILKKK GLLRLAAKGTTRAG--DGGHAYLKEWMWWA--GLIT---MGAGEAANFLAYAFAPASLVTPLGALSVLVS---AVLSSYF LDERLNLHG--------KMGCVLSILGSTVIVIHAPQTEEVADLADMGVKLRDP--IFVTYAVIV--------LAVSLYL IFYIAPRHGTSNVMIYISICSLLGAFSVSCVKGVGLVVKGAAAGDP-----VWLQPLTYLLILGLIA--SVSTQVNYLNK ALDVFNT-SMVTPVYYVLFTTTVLLCS-----AILFKEWNAMDPRSVIGMLAGFGTIVTGIFFLHAFKDINFSLSDL-PK FVKNVGANGVVESVKYTSVRKA----HRSDERSE-------------LLDQVD-AIYSEEDE-SSNVL------------ ------------------------- >Strongylocentrotus_purpuratus_NIPA2 ------------------------------------------------------------------MSPVAESDEPHKNI TGAVWHELQQAISTQATSMTTITPSFMSTSNS---------TMACDISEETMTSEDFYIGLTLAICSSGFIGSSFVIKKQ ALIKISAH-AVRAG--DGGHAYLREWLWWA--GFLL---LGLGELCNFMAYAFAPATLVTPLGALSVIVS---AVLSSYV LNETLNLLG--------KLGCILCIMGSIIIVLHTPADEAFHTLGWLATRLRSP--SFVIYVCLV--------AASCLAL VFAIGPRWGHTNILVYVLVCSLMGSLTVMASKGVGIAFVQLFDGTN-----TFVDPLTWILILLMVV--FITIQMHFLNK SLDIFNT-AVITPIYYVFFTASVLIAS-----SLLFEDWRAMTATDIIAVLDGFGVIIVGIFLLHTFRDFSLSLTDLPSA EKPSTSTG-----ATSVHRPRTDSEDCYINTESA------------CLLNDFNSKNDGILSEKDIA-------------- ------------------------- >Drosophila_melanogaster_NIPA2 -------------------------------------------------------------------------------- MNSDGEASSLQMPQVTVGGMLPVEANQSPETA------------PLSMAETVSNTDFYIGVGLAISSCFFIGSSFIIKKK ALIRLSRYGEVRAS--AGGFGYLREWIWWA--GLLT---MGVGEAANFAAYAFAPASLVTPLGALSVIIS---AVMASRF LNEKLNLLG--------KIGCFLCILGSTIIVIHSPKEKEIEDLQLLFDMLLDP--VFILYVICI--------VGSTVFV ACFIAPRHGHTNVVVYIFLCSGIGSLTVMSCKALGLAIRQTLNNGGN----VFLTWMPWFLILVTVT--FIAIQMNYLNK ALDIFNT-SIVTPVYYVMFTTLVIAAS-----AILFKEFTHMRFDDILGDVCGFLIVITAVFLLNAFRDIDISLNDVRGL MRPKM-----------QRVSQF-------DEEVL-----------------VTSNTKERRLSYGSSDIFRKA-------- ------------------------- >Apis_mellifera_NIPA2 -------------------------------------------------------------------------------- --------------------------MSSITK------------IAFEVQLYNTTNFYIGLGLAISSSIFIGASFIIKKK ALIRLQRRGALRAS--SGGFGYLKEWMWWT--GFLS---MGIGEAANFAAYAFAPASLVTPLGALSVLIS---AILASKY LHEKLNLLG--------KIGCLLCILGSTILIIHSPKEEEINTLNELLDKVKDP--GYIVYILIV--------IICSILI IFYFGPIYGKQNIIVYICLCSSIGSLTVTSCKGLGLALKETIFGFSN----GFSNWLTWAFLFSVIL--CVSIQMNYLNR SLDLFET-TIVTPIYYVFFTTLVIIAS-----AILFKEWENMSAEDILGSFCGFLTIIIAIFLLNAFKEMDISYENIRRM LQPKR-----------KLFINSNNQWNNRDEERL-----------------ITRLETELNHTYGAQALTRTI-------- ------------------------- >Anopheles_gambiae_NIPA2 -------------------------------------------------------------------------------- -------------KITRGVKKMPSAGAAAPPP------------PPAIDELYMERDFYIGLALALSSSIFIGSSFIIKKI GLLRLSRVGSVRAS--AGGFGYLRDWIWWA--GLIC---MGVGEAANFAAYAFAPASLVTPLGALSVIVA---AVMASRF LKERLNLLG--------KLGCFLCIVGSTIIVIHSPKEGEVEDLNLLIDMLQDP--TFITYVVLI--------LSLALFI GCCIGPRYGHKHVAVYILLCSAIGSLTVMSCKALGLALRDTLSGKSN----DFGMWLPYFLIIVTVV--FVGIQVNYLNK ALDIFNT-SIVTPIYYVIFTTLVITAS-----AILFKEWRHMRPEDIIGDLCGFFVVIVAVILLNAFREMDISLSDVKGI MRPKR-----------ELLSH----------------------------------------------------------- ------------------------- >Nematostella_vectensis_NIPA2 -------------------------------------------------------------------------------M AVSTSAWPSTQGIATSDRMSRDASEAS--------------------------SRDFYTGLGLAISSSVFIGSSFIVKKK GLLRVAQRSGVRAG--QGGYAYLKEWLWWI--GMIS---MIFGEIANFSAYAFAPAILVTPLGALSVLVS---AVLASYF LDEKQNLHG--------KVGCILSIIGSTVLVIHAPQEEAVDTIEQLESKLIEP--GFIIYAVMV--------VLLAFVL IWRYAPKYGKTNILVYIAICSLIGSLSVMGCKGVGIVLKQTLKGDS-----QVGNPVSWALLFTVLT--CATTQINYLNK ALDIFNT-SLVTPIYYVMFTLLTIIAS-----AILFKEWKLMDTKDTIGSICGVLTIILGVFLLHAFKNVKFSLKDLNFF QKQKGSRS----IQIGDGAEA-----MLMR------------------SVEEGSPDDED-EEIASSKLLTNNINHT---- ------------------------- >Hydra_magnipapillata_NIPA2 ---------------------------------------------------------------------------MAVHL HIAEIIDTATNTSLSTTTINMATSQIN--------------------------YGDYYKGLALALSSCVFIGTSFIVKKK GLLRVSRTSGSRAG--EGGYAYLKEWMWWI--GLIT---MVVGEAANFTAYAFAPAILVTPLGAISVIVR---EIDEG-- LSKS-----------------AMKMVG----IKHG---IPKNTLQAFTGRL------FIGYTLLV--------LLISIFL IIYVSPKYGKTNILVYIAICSLFGSLTVSACKGLGIAIKETLAHNS-----QVSNPIAWMLLIGGAL--CIMVQMNFLNK ALDIFNT-SIVSPIYYVMFTTFAIIAS-----AILYKEWAKLNAKDALGSVCGFLTIIIGVFLLHAFKDIKFSFQDL--- -YGSVTIS----KNLTDGEAN-----VLIT------------------ELE---SDEEN-DSNISNNYLTSKF------- -------------------------