>Homo_sapiens_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MAAAVRMNIQMLLEAADYLERRE------ -REAEHGYASMLPYNN----KDRDALKRRNKSKKNNSS-----------------------------------SRSTHNE MEKN--RRAHLRLCLEKLKGLVPLGPESSRHTT-LSLLTKAKLHIKK-LEDCDRKAVHQIDQLQR-------EQRHLKRQ LEKL--------------------------------------------------------------------------GI ERIR------------MDSIGSTVSS-----------ERSDSDRE------------EIDVDVES--------------T DYLTGDLDW-----------------------SSSSVSDSD--ERGSMQSLGSDEGYSSTSIKRIKLQDSHKA-CLGL-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Pan_troglodytes_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MAAAVRMNIQMLLEAADYLERRE------ -REAEHGYASMLPYNN----KDRDALKRRNKSKKNNSS-----------------------------------SRSTHNE MEKN--RRAHLRLCLEKLKGLVPLGPESSRHTT-LSLLTKAKLHIKK-LEDCDRKAVHQIDQLQR-------EQRHLKRQ LEKL--------------------------------------------------------------------------GI ERIR------------MDSIGSTVSS-----------ERSDSDRE------------EIDVDVES--------------T DYLTGDLDW-----------------------SSSSVSDSD--ERGSMQSLGSDEGYSSTSIKRIKLQDSHKA-CLGL-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Macaca_mulatta_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MAAAVRMNIQMLLEAADYLERRE------ -REAEHGYASMLPYNN----KDRDALKRRNKSKKNNSS-----------------------------------SRSTHNE MEKN--RRAHLRLCLEKLKGLVPLGPESSRHTT-LSLLTKAKLHIKK-LEDCDRKAVHQIDQLQR-------EQRHLKRQ LEKL--------------------------------------------------------------------------GI ERIR------------MDSIGSTVSS-----------ERSDSDRE------------EIDVDVES--------------T DYLTGDLDW-----------------------SSSSVSDSD--ERGSMQSLGSDEGYSSASIKRIKLQDSHKA-CLGL-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Mus_musculus_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MATAVGMNIQLLLEAADYLERRE------ -REAEHGYASMLPYS-----KDRDAFKRRNKPKKNSTS-----------------------------------SRSTHNE MEKN--RRAHLRLCLEKLKGLVPLGPESSRHTT-LSLLTKAKLHIKK-LEDCDRKAVHQIDQLQR-------EQRHLKRR LEKL--------------------------------------------------------------------------GA ERTR------------MDSVGSVVSS-----------ERSDSDREEL----DVDVDVDVDVDVEG--------------T DYLNGDLGW-----------------------SSS-VSDSD--ERGSMQSLGSDEGYSSATVKRAKLQDGHKA-GLSL-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Rattus_norvegicus_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MATAVGMNIQLLLEAADYLERRE------ -REAEHGYASMLPYSS----KDRDAFKRRNKPKKNSTS-----------------------------------SRSTHNE MEKN--RRAHLRLCLEKLKGLVPLGPESSRHTT-LSLLTKAKLHIKK-LEDCDRKAVHQIDQLQR-------EQRHLKRR LEKL--------------------------------------------------------------------------GA ERTR------------MDSVGSVVSS-----------ERSDSDREELDVDVDVDVDVDVDVDVES--------------T DYLNGDLGW-----------------------SSS-VSDSD--ERGSMQSLGSDEGYSSASVKRAKLQDGHKA-GPGL-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Canis_familiaris_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MAAAVRMNIQMLLEAADYLERRE------ -REAEHGYASMLPYSN----KDRDALKRRNKSKKNNSS-----------------------------------SRSTHNE MEKN--RRAHLRLCLEKLKGLVPLGPESNRHTT-LSLLTKAKLHIKK-LEDCDRRAIHQIDQLQR-------EQRHLKRQ LEKL--------------------------------------------------------------------------GI ERIR------------MDSIGSTVSS-----------ERSDSDRE------------EVDVDVDVDVDGDAE------GA DYLAGELDW-----------------------SSSGVSDSD--ERGSLRSAGSDEGYASSSRRRPAAPHARG----GL-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Bos_taurus_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MAAAVRMNIQMLLEAADYLERRE------ -REAEHGYASMLPYNN----KDRDALKRRSKSKKNNSS-----------------------------------SRSTHNE MEKN--RRAHLRLCLEKLKGLVPLGPESNRHTT-LSLLTKAKLHIKK-LEDCDRKAIHQIDQLQR-------EQRHLKRQ LEKL--------------------------------------------------------------------------GI ERIR------------MDSTGSTVSS-----------ERSDSDRE------------EIDVDVES--------------T DYLTGDLDW-----------------------SCSSVSDSD--ERGSMQSLGSDEGYSSSSVKRIKLQDSHKTTCLGL-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Dasypus_novemcinctus_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---AEHGYASMLPYNN----KDRDALKRRNKSKKNNSS-----------------------------------SRSTHNE MEKN--RRAHLRLCLEKLKGLVPLGPESNRHTT-LSLLTKAKLHIKK-LEDCDRKAIHQIDQLQR-------EQRHLKRQ LEKL--------------------------------------------------------------------------GI ERIR------------MDSIGSTVSS-----------ERSDSDR------------EEIDVDVES--------------T DYLTGDLDW-----------------------SSSSVSDSD--ERGSTQSLGSDEGYSSSSIKRIKLQDNHKT-CLGL-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Monodelphis_domestica_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------MAVAAAAVRMNIQLLLEAADYLERRE------ -REAEHGYASMLPYNN----KDRDALKRRSKSKKNSSS-----------------------------------SRSTHNE MEKN--RRAHLRLCLEKLKGLVPLGPESNRHTT-LSLLTKAKLHIKK-LEDCDRKAVHQIDQLQR-------EQRHLKRQ LEKL--------------------------------------------------------------------------GI ERIR------------MDSIGSTVCS-----------ERSDSDR------------EEIDVDVES--------------T DYLTGDLDW-----------------------SSSSVSDSD--ERGSMQSLCSDEGYSSSSIKRIKLQDNHKT-CLSL-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Anolis_carolinensis_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------MATAAQVRENIRMLLEAAEFLERRE------ -REAEHGYASMLPYSA----NDRDAFKRRNKSKKNSSN-----------------------------------SRSTHNE MEKN--RRAHLRLCLEKLKGLVPLGPESSRHTT-LSLLTKAKLHIKK-LEDCDRRAIHQIDQLQR-------EQRHLRRQ LEKL--------------------------------------------------------------------------GI ERIR------------TDSTGSAVSS-----------ERSDSDRGEMD----LQAEEDVDVDVES--------------T DDLAGELDW-----------------------SSSSSSPSDSDERGSLQSLCSDEGYSSAGLQRIKPPDTLTA-CLGL-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Danio_rerio_MXD1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MTAIEK-LQMLIEAAEYLDRRE------ -REAEHGYASMLPFTSN---KERDGLKRKIKSKKNCS------------------------------------SRSTHNE MEKN--RRAHLRLCLERLKSLVPLGPESNRHTT-LSLLMRAKEHIKR-LEDSERKAQHTIDQLQR-------EQRHLRRR LEQL--------------------------------------------------------------------------GV ERTR------------MDSMGSTISS-----------DKSDSDQ------------EEVDVDVEG--------------T DYLLGDLEW-----------------------STSSVSDS--DERGSLRSSCSDEGYSSASLRR--LANSQEN-SLVLAC SL------------------------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------- >Takifugu_rubripes_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MAAIGL-VQMLIEAAEYLDRRE------ -REAEHGYASMPPFISS---RERESLKRKSKSKKNTS------------------------------------SRSVHNK LRSTL-KRAHLRLCLERLKSLVPLGPDANRHTT-LSLLMKAKDHIKK-LEESDRRAQHTMDQLQR-------EQRYLRRR LEQL--------------------------------------------------------------------------GV ERTR------------MDSTGSNLSS-----------DKSDSDQ------------EDLDVDVEG--------------T DFMLGDLEW-----------------------STSSVSDSG-DERSSLRSSCSDEGYASASLQR--LQNTQET-AKQLGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Tetraodon_nigroviridis_MXD1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------KMAAIGL-VQMLIEAAEYLDRRE------ -REAEHGYASMPPFISS---RERENLKRKSKSKKNTSN-----------------------------------SRSTHNE MEKN--RRAHLRLCLERLKSLVPLGPDANRHTT-LSLLMKAKDHIKK-LEESDRRAQHTMDQLQR-------EQRYLRRR LEQL--------------------------------------------------------------------------GV ERTR------------MDSTGSNLSS-----------EKWESDQVLQPLSL-SASTEDLDVDVEG--------------T DYMLGDLEW-----------------------STSSVSDSG-DERSSLR------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Gasterosteus_aculeatus_MXD1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------KMAAIGM-VQMLIEAAEYLERRE------ -REAEHGYASMPPFTSS---QERESLKRKSKSKKNTS------------------------------------SRSTHNE MEKN--RRANLRLCLERLKSLVPLGPDANRHTT-LSLLMKARDHIKR-LEESDRRAQHTVEQLQR-------ERRHLRRR LEQL--------------------------------------------------------------------------GV ERTR------------MDSTGSNAS------------DKSDSDQVRLLFS----QTEDLDVDVEG--------------T DYLLGDLEW-----------------------STSSVSDSG-DERGSLRSSCSDEGYSSASLLL--LQDTQER-AKQI-- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Oryzias_latipes_MXD1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------------RSTHNE MEKN--RRAHLRLCLERLKSLVPLGPDASRHTT-LSLLMKAKDHIKR-LEEGDRKAQHTLDQLQR-------ERRHLRRR LEQL--------------------------------------------------------------------------GV ERTR------------MDSTGSTRS----------------SDNV----------TEDLDVDVEG--------------T DYLLGDLEW-----------------------SISSVSDSG-DERSSLRSSCSDEGYASASLLR--LQDS---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Ciona_intestinalis_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------MLKGLQIGKVDLLLQAAEFLENKDKR---- DRETEHGYATPAYRIGQNFRTKVKTVRRSQNR-------------------------------------------TSHNE LEKN--RRAHLRNCLDGLKAIVPLNQDATRHTT-LGLLTQARALIEN-LKHERQAVICEKTRLEE-------HGALLRHR LHQLEIS------------------------------------------------------------------------- RRRR-------------DSTGSSWSSG-----------RSESSND---------------SDKDE--------------- --EIIDVMDCS--------------------EACESLHALQSSVRPNLITINVPKALSLSTRVKQAKIAT---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Branchiostoma_floridae_MXD1 --------------------------MKANGLPYVGKRGTCLDDCVFGNDGTPDRDLPQHHLQGGCFLGRRPSAGFWYSL AVCLETSVFHRRFLPCDAVHKEGCEVTVERQAVDEVGPPALEGVDGLSLTKRSKRTISLYSWKSKTLHEEYDMLTKKRKA KAAMILIGMETRLASWVTIISPGPRDDLTRVAGGKQTQRTTTISLSKWRKTEISVKMMGIATLLEAAEFLERRER----- --EAEHGYASTLPYPHEIPPRKRTKSSSSSRRSQASSR-------------------------------------TTHNE LEKN--RRAHLRNCLERLKAIIPLSPETPRHTT-LGLLNKAKNEIRR-LEDENRRNSSSREQLFR-------QQRQLKRK LEMLH--------------------------------------------------------------------------- RKIR------------HDSTGSMSDN------------RSDSSDE-------------IDVEFGGD-------------S PTLTADSAYRS--------------------NSPGTSSDYAYGSNSPGTNSDFDENGSTSSDCGYTSSFIKQLS------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Strongylocentrotus_purpuratus_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MEDVSILNIEQLLQAAEFLERRER----- ----EHGYASPYSHEANNK-RKHRVKRLNSNSSR-----------------------------------------STHNE LEKN--RRAHLRTCLERLKEMVPLDGDMPRHTT-LGLLTNAKDFIVD-LEEKSEGFTSHKDQLCR-------EQRFLRRR LDYL--QSTLH--------------------------------------------------------------------- -RQR------------QDSTGSSLASDD-------------SEKD--------------DVDVIG--------------- -YDS---DN----------------------------------RSIESDMNSSDGDLAVATKEIIITDL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Caenorhabditis_elegans_MXD1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------MEQQLNLGHLLTAARLLDIGALDISSLDLGALTSTSSSPGSSSPAMFDLSNESELRSLFCGKL KVDKKQSSCASNASTSSQPYCSSPPARKSSKHSR-----------------------------------------TAHNE LEKT--RRANLRGCLETLKMLVPCVSDATRNTT-LALLTRARDHIIE-LQDSNAAQMKKLNDLRD-------EQDELVAE LAQLQADEEVAQATS-----------------------------------------------------------QACQTL SQSR------------PESRASSFTS------------TSSRDSP-----------CYLEYSPSSKP-----------MD SHKPTIIDLYAEG---------------LIPRGPITFPRPLVYPHNVFDLMNLPPTPFDVSQFLPINLQV---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Homo_sapiens_MXD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MEPLASNIQVLLQAAEFLERRER----- --EAEHGYASLCPHRSPGPIH-RRKKRPPQAPGAQDSG------------------------------------RSVHNE LEKR--RRAQLKRCLERLKQQMPLGADCARYTT-LSLLRRARMHIQK-LEDQEQRARQLKERLRS-------KQQSLQRQ LEQLRGLAGAA-------------------------------------------------------------------ER ERLR------------ADSLDSSGLSS----------ERSDSDQGEC-------------PEAEG--------------L CGPRGEPGLLT--------------------GPLPAQRSWR--WMWRAWCLGVRPSCCGASSPARSTATRTAAAPGYDVP HPGRASALYS-CQAHLPGRSPPQAFRAARSHLLEWTKRTLVWEQVLPKHPAAGCQAGPLEGKGQDSSGPPWTPAGQAAWA RAQAFGSAAPKGTGSLLGLFPSWTRPPAFASHKLYSIFIKSLFHNFPSIVLPNENGGTPNHRPTGRGNNISSHH------ -------------------------------------------------------- >Pan_troglodytes_MXD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------RPPEAPGLSGIG------------------------------------RSVHNE LEKR--RRAQLKRCLERLKQQMPLGADCARYTT-LSLLRRARMHIQK-LEDQEQRARQLKERLRS-------KQQSLQRQ LEQLRGLAGAA-------------------------------------------------------------------ER ERLR------------ADSLDSSGLSS----------ERSDSDQEEL------------EVDVES--------------L VFGG-EAELLR--------------------G----------------FVAGQEHSYSHGGG----AWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Macaca_mulatta_MXD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MEPVASNIQVLLQAAEFLERRER----- --EAEHGYASLCPHRSPGPIH-RRKKRPPQAPGAQDSG------------------------------------RSVHNE LEKR--RRAQLKRCLERLKQQMPLGADCARYTT-LSLLRRARMHIQK-LEDQEQRARQLKERLRS-------KQQSLQQQ LEQLRGLAGAA-------------------------------------------------------------------ER ERLR------------TDSLDSSGLSS----------ERSDSDQGEC-------------PEAEG--------------L CGPWGKPGLLI--------------------GPLPAQRSWR--WMWRAWCLGVRPSCCGASSPARSTATRTVAAPGYDVP HPGVASLPSAHARPTCQAGALPKPLGLLGVTYWNGLKGPLCGNRCSPNTLLLAARQALWKGKGQDSSGPPWTPAGQAAWA -------------------------------------------------------------------------------- -------------------------------------------------------- >Mus_musculus_MXD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MEPVASNIQVLLQAAEFLERRER----- --EAEHGYASLCPHHSPGTVC-RRRKPPLQAPGALNSG------------------------------------RSVHNE LEKR--RRAQLKRCLEQLRQQMPLGVDCTRYTT-LSLLRRARVHIQK-LEEQEQQARRLKEKLRS-------KQQSLQQQ LEQLQGLPGAR-------------------------------------------------------------------ER ERLR------------ADSLDSSGLSS----------ERSDSDQEDL------------EVDVES--------------L VFGT-ETELLQ--------------------S----------------FSAGREHSYSHSTC----AWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Rattus_norvegicus_MXD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MEPVASNIQVLLQAAEFLERRER----- --EAEHGYASLCPHHSPGTVC-RRRKAPLQAPGALNSG------------------------------------RHVHNE LEKR--RRAQLKRCLEQLRQQMPLGVDHTRYTT-LSLLRRARMHIQK-LEEQEQQAQRLKEKLRS-------RQQSLQQQ LEQLQGLLGVR-------------------------------------------------------------------ER DRLR------------ADSLDSSGLSS----------ERFDSDQEDL------------EVDVES--------------L VFGT-ETELLQ--------------------S----------------FSAGQEHSYSHSTG----TWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Canis_familiaris_MXD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MEPVASNIQVLLQAAEFLERRER----- --EAEHGYASLYPHRSPGPVY-RRRKRSPQASGALDSG------------------------------------RSVHNE LEKR--RRAQLKRCLEQLKQQMPLGADCARSTT-LSLLRWARVHIQK-LEEQEQQARRLKEKLRS-------KQQSLQRQ LEWLRGLAGPG-------------------------------------------------------------------ER ERPR------------ADSLDSSGLSS----------ERSDSDQEEV------------EVDVES--------------L VFGG-EAELLR--------------------G----------------FSAGQEHSYSHSSS----TWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Bos_taurus_MXD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MEPVASNIQVLLQAAEFLERRER----- --EAEHGYASLCPHRSPGPVH-RRRKRSPQAPGALDSG------------------------------------RSVHNE LEKR--RRAQLKRCLEQLKQQMPLGADCVRYTT-LSLLRRARMHIQK-LEEQEQRARQLKEKLRS-------KQQSLRRQ LEQLRGLGTVG-------------------------------------------------------------------ER ERLR------------ADSLDSSGLSS----------ERSDSDQEEL------------EVDVES--------------L VFGG-EAELLR--------------------G----------------FSAGQEHSYSHSGS----AWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Myotis_lucifugus_MXD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MESVASNIQVLLQAAEFLERRER----- --EAEHGYASLFPHRSPGPVH-RKRKGSPQALGALDSG------------------------------------RSVHNE LEKR--RRAQLKQCLEQLKQQMPLGADCARYTT-LSLLRRARMHIQK-LEEQEQRAQRLKEQLRS-------KQQSLQQQ LEQLRAPVGAG-------------------------------------------------------------------ER ERLR------------ADSLDSSGLSS----------ERSDSDQGEC-------------PEAEG--------------G VGS--GPGLLT--------------------RPVPVQRNWR--WTWRAWCSGVRPSCCGASVRARSTATHT-AAPGYDPC HPRACLCPQTTLCSTQPGRSPPQASRAAQS-LLEWTKRTLAWEPALSCPSAGCCSAS--EGRG-EGAWPPLSPARQAFFV ---ALGSVVPTGTGSLLG--PSPQGPLAFAP--YCTVFSLKGFHHFLPMVLPDENGETP-ATKWERGNEISHYN------ -------------------------------------------------------- >Monodelphis_domestica_MXD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MEQGASSIQVLLQAAEYLDRRER----- --EAEHGYASLCPTHSLGPVN-RGR-RRPKAP--RDSL------------------------------------RSMHSE LEKH--RRAQLRHCLEQLKQQMPLSTDCARYTT-LSLLRRARLHIQK-LEEQEQRARRLKDRLRS-------EQRSLRQR LEQLQG--AGG-------------------------------------------------------------------EW ERLR------------VDSLDSSGLSS----------ERSDTDQEEL------------EVDVES--------------L VFGG-DAELLR--------------------G----------------FSTGQEHSYSHSGS----AWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Erinaceus_europaeus_MXD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------------------------SAHNE LEKR--RRAQLKRCLEQLKQQMPLGADCARYTT-LSLLRRARVHIQK-LEEQEQRARRLKEKLRS-------QQQSLRRQ LEQLRGPMGG---------------------------------------------------------------------- ERLR------------ADSLDSSGLCS----------ERSDSDQEEL------------EVDVES--------------L VFGS-EAELLR--------------------G----------------FSAGQEHSYSHRGA----AWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Anolis_carolinensis_MXD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MELVASNIQVLLQAAEYLERRER----- --EAEHGYASLSPHCGRDARQSRRRPKPRKAVKSLRFGF-----------------------------------RSAHNE LEKH--RRAQLRHCLEQLKQQIPMNTEHSRYTT-LNLLHRARLHIKK-LEDQEEKARRQKERLRS-------EQRNLHQR LEELLAHSS----------------------------------------------------------------------V ERPR------------ADSLDSSRFSS----------EHSDSATEDA------------EVDVEG--------------L AFISTEEDVVA--------------------A----------------ISTGQEHSYSNTNN----VWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Xenopus_tropicalis_MXD3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MEQLPSNLQVLLQAAEYVERRER----- --EAEHGYASILPCDPATPGR-RKRQRTNSNP---DNV------------------------------------RSVHNE LEKH--RRAQLRRCLEQLKQQVPLSMENSRHTT-LSLLHRAKQHIKK-LEDQELRAKSLKEKLRV-------EQQKLRQR LKQLLPP-----------------------------------------------------------------------NT ERIR------------TDSLDSSTLSS----------ERSDSDQEDL------------EVDVEG--------------I ILSGNEGELFV--------------------S----------------FSAGLEHSYSTPAH----AWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Danio_rerio_MXD3a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MEVNTCNIQVLLQAAEYLERRER----- --EAEHGYASVLPFYSNGVSDKRKKQKSKSHSSPGNS-------------------------------------RSVHNE LEKH--RRAQLRHCLEQLKQQVPLSSDSSRNTT-LNLLRQAQLHIKK-LQEQDERAKLLKDRLRW-------EQRELRTR LEKLQG------------------------------------------------------------------------GS ERMR------------NDSLGSA-VSS----------ERSDSEREDV------------EIDVES--------------M VWTL-EADALG--------------------SS----------------HAGVDHSYSTSDH----AWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Takifugu_rubripes_MXD3a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDS-VYNIQVLLRAAEFLERKER----- --EAEHGYASVLPLSPD-HPDKRSKQKSKKMSGGGNSC------------------------------------RVVHNE LEKN--RRAQLRQCLEQLKKQVPLSSDSVRNTT-LNLLRRAQLHIKK-LQEQDELAQQMKGRLRW-------QQRELRVR LEQLQR------------------------------------------------------------------------GS ERMR------------NDSQGSS-MSS----------ERSDSDREDV------------EVDVES--------------I VFDCVDSEGLS--------------------IT----------------HADADHCYSSLDK----SWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Tetraodon_nigroviridis_MXD3a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDG-VYNIQVLLRAAEFLERRER----- --EAEHGYASVLPLSPD-HPDKRSKQKNKKMSGGGN--------------------------------------RVVHNE LEKN--RRAQLRQCLEQLKKQVPLSPDSVRNTT-LNLLRRAQLHIKK-LQEQDELAERLKGRLRW-------QQRELRVR LEQLQR------------------------------------------------------------------------GS ERMR------------NNSQGSS-MSS----------ERSDSDREDV------------EVDVES--------------I MFDCVDSDGLS--------------------IS----------------HMDADHCYSSPDK----SWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Gasterosteus_aculeatus_MXD3b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MDGNICNIQVLLRAAEFLERRER----- --EAEHGYASLQPLSPD-PSDKRSKQKSKKTSSGGN-------------------------------------------- ------RRAQLRECLEQLKKQVPLSSDSMRNTT-LNLLRRAQLHIKK-LKEQDQRAEQLKGRLRW-------EQRELRVR LEQLQR------------------------------------------------------------------------GS ERMR------------NDSHGST-MSS----------ERSDSDREDV------------EVDVES--------------I VFDCLDSDGLS--------------------IT----------------HTGADHCYSSMDK----AWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Oryzias_latipes_MXD3a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MEGHICNIQVLLRAAEFLERRER----- --EAEHGYALVLPISSP-HSDKTGKQKSKKISVGGNSSN-----------------------------------RSVHNE LEKNRCRRAQLRHCLEQLKKQVPLSSDSSRNTT-LSLLRQAQLHIKK-LQEQDERAEQLKGRLLW-------EQRELRIR LEQLER------------------------------------------------------------------------GT ERMR------------NNSHGST-MSS----------ERSDSDTEDV------------EVDVES--------------I VFEC-DSDELS--------------------IT----------------HTGADHCYSSMDK----AWL----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Homo_sapiens_MXD4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MELNSLLILLEAAEYLERRDR----- --EAEHGYASVLPFDGDFAREKTKAAGLVRKAP---NNR------------------------------------SSHNE LEKH--RRAKLRLYLEQLKQLVPLGPDSTRHTT-LSLLKRAKVHIKK-LEEQDRRALSIKEQLQQ-------EHRFLKRR LEQLSVQS-----------------------------------------------------------------------V ERVR------------TDSTGSAVST-------------DDSEQ---------------EVDIEG--------------M EFGPGELD------------------------SVGSSSDAD--DHYSLQSGTGGDSGFGPHCRRLGRPALS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Pan_troglodytes_MXD4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------NR------------------------------------SSHNE LEKH--RRAKLRLYLEQLKQLVPLGPDSTRHTT-LSLLKRAKVHIKK-LEEQDRRALSIKEQLQQ-------EHRFLKRR LEQLSVQS-----------------------------------------------------------------------V ERVR------------TDSTGSAVST-------------DDSEQ---------------EVDIEG--------------M EFGPGELD------------------------SVGSSSDAD--DHYSLQSGTGGDSGFGPHCRRLGRPALS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Macaca_mulatta_MXD4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MELNSLLILLEAAEYLERRDR----- --EAEHGYASVLPFDGDFTREKTKAASLVRKAP---NNR------------------------------------SSHNE LEKH--RRAKLRLYLEQLKQLVPLGPDSTRHTT-LSLLKRAKVHIKK-LEEQDRRALSIKEQLQQ-------EHRFLKRR LEQLSVQS-----------------------------------------------------------------------V ERVR------------TDSTGSAVST-------------DDSEQ---------------EVDIEG--------------M EFGPGELD------------------------SVGSSSDAD--DHYSLQSGSGGDSGFGPHCRRLGRPALS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Mus_musculus_MXD4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MELNSLLLLLEAAEYLERRDR----- --EAEHGYASVLPFDGDFARKKTKTAGLVRKAP---NNR------------------------------------SSHNE LEKH--RRAKLRLYLEQLKQLVPLGPDSTRHTT-LSLLKRAKMHIKK-LEEQDRRALSIKEQLQR-------EHRFLKRR LEQLSVQS-----------------------------------------------------------------------V ERVR------------TDSTGSAVST-------------DDSEQ---------------EVDIEG--------------M EFGPGELD------------------------SAGSSSDAD--DHYSLQSSGCSDSSYGHPCRRPGCPGLS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Canis_familiaris_MXD4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------VGEVGSPGARGGRRAEPAGEGRAAAAAVTESAGGRGMKRNSLLILLEAAEYLERRDR----- --EAEHGYASVLPFDGDFARKKTKAAGLVRKAP---NNR------------------------------------SSHNE LEKH--RRAKLRLYLEQLKQLVPLGPDSTRHTT-LSLLKRAKMHIKK-LEEQDRRALSIKEQLQR-------EHRFLKRR LEQLSMQS-----------------------------------------------------------------------L ERVR------------TDSTGSAVST-------------DDSEQ---------------EVDVEG--------------M EFGPGELD------------------------SVGSSSDVD--DHYSLQSGGCSDGGYGPPCRRPGRPGLS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Bos_taurus_MXD4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MELNSLLILLEAAEYLERRDR----- --EAEHGYASVLPFDGDFARKKTKAAGLVRKAP---NNR------------------------------------SSHNE LEKH--RRAKLRLYLEQLKQLVPLGPDSTRHTT-LSLLKRAKMHIKK-LEEQDRRALSIKEQLQR-------EHRFLKRR LEQLSAQS-----------------------------------------------------------------------L ERVR------------TDSTGSAVST-------------DDSEQ---------------EVDVEG--------------M EFGPGELD------------------------SVGSGSDVD--DHYSLRGGGCSHGSFGPPCRRPGRPGLS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Monodelphis_domestica_MXD4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MEWNSLLLLLEAAEYLERRDR----- --EAEHGYASVLPFDSEYSRKKTKTA-ALARKSQ--NNR------------------------------------SSHNE LEKH--RRAKLRLYLEQLKQLVPLGPDSTRHTT-LSLLKRARMHIKK-LEEQDRKALNVKEQLQR-------EHRYLKRR LEQLSVQG-----------------------------------------------------------------------M ERVR------------TDSTGSTIST-------------D-SEQ---------------EVDIEG--------------M EFTPGEMD------------------------SVGSASDAD--DHYSLGSGSSDS--SYSHSRRLS-GRLS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Gallus_gallus_MXD4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MELNSLLILLEAAEYLERRDR----- --EAEHGYASVLPFDSDYSRKKTKAG-SMARKSP--NNR------------------------------------SSHNE LEKH--RRAKLRLYLEQLKQLVPLGPDSTRHTT-LSLLKRAKMHIKK-LEEQDRKALNIKEQLQR-------EHRYLKRR LEQLSVQG-----------------------------------------------------------------------M ERIR------------TDSMGSTIST-------------D-SEQ---------------EVDIEG--------------M EFTPGEMD------------------------SIGSASDAE--DHYSLQSGSSDG--GYSHSRRLN-ARLS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Taeniopygia_guttata_MXD4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MELNSLLILLEAAEYLERRDR----- --EAEHGYASVLPFDSDYSRKKTKAG-TMARKSQ--NNR------------------------------------SSHNE LEKH--RRAKLRLYLEQLKQLVPLGPDSTRHTT-LSLLKRAKMHIKK-LEEQDRKALNIKEQLQR-------EHRYLKRR LEQLSVQG-----------------------------------------------------------------------M ERIR------------TDSMGSTIST-------------D-SEQ---------------EVDIEG--------------M EFTPGEMD------------------------SIGSASDAE--DHYSLQSGSSDG--GYTHSRRLN-ARLS--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Anolis_carolinensis_MXD4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MEWNSLLMLLEAAEYLERRER----- --EAEHGYASVLPFESDHPGRKTKFG-----KSP--NNR------------------------------------SSHNE LEKH--RRAKLRLYLEELKQLVPLGADSTRHTT-LSLLKRAKMHIKK-LEEQDRKALNIKEQLQR-------EHRYLKRR LEQLSMQG-----------------------------------------------------------------------L ERIR------------TDSLGSTLST-------------D-SEQ---------------EVDIEG--------------I EFTAAGMD------------------------NSGSTSD----AEDSFQGSSSDG--GYTYSLRVN-TRLL--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Takifugu_rubripes_MXD4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------ESQPRCLNIGILLEAAEYLERRDR----- --EAEHGYASVLPYTSDFSRKKTKASPMS-RKTQ--NNR------------------------------------SSHNE LEKH--RRAKLRLYLEQLKKLVPLGPDSTRHTT-LSLLKRAKMHIKK-LEEQDRKALNTKEQLQR-------EHRYLKRR LEQLSVSGS----------------------------------------------------------------------V ERIR------------TDSMGSTIST-------------D-SEQGSLSLV-------NTEVDIEG--------------M EFTPVEAD------------------------SVDSISDGEEEDHYSLQSSSSDTSYTATHSHRLQ-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Tetraodon_nigroviridis_MXD4a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MELNSLLILLEAAEYLERRDR----- --EAEHGYASVLPYTNDFSRKKTKASPMS-RKTQ--NNR------------------------------------SSHNE LEKH--RRAKLRLYLEQLKKLVPLGPDSTRHTT-LSLLKRAKMHIKK-LEEQDRKALNTKEQLQR-------EHRYLKRR LEQLSVSGS----------------------------------------------------------------------V ERIR------------TDSMGSTIST-------------D-SEQ---------------EVDIEG--------------V EFTPVEAD------------------------SVDSISD----DQYGLQSSSSDTSYTATHSHRLQ-PHHC--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Gasterosteus_aculeatus_MXD4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MELNSLLILLEAAEYLERRDR----- --EAEHGYASVLPYRSDFSTKKTKASAIS-RKPL--NNR------------------------------------SSHNE LEKHS-RRAKLRLYLEQLKKLVPLGPDSTRHTT-LSLLKRAKMHIKK-LEEQDKKALNTKEQLQR-------EHRYLKRR LEQLSVSGS----------------------------------------------------------------------V ERIR------------TDSLGSTIST-------------D-SEQ---------------EVDIEG--------------I EFTPVEAD------------------------SVDSISD----DHYSLQSSSSDTSYTATHSHRLQ-PHHC--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Oryzias_latipes_MXD4a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MELNSLLILLEAAEYLERRDR----- --EAEHGYASVLPYTNDFSRKKTKTSTMS-RKTQ--NNR------------------------------------SSHNE LEKH--RRAKLRLYLEQLKKLVPLGPDSTRHTT-LSLLKRAKMHIKK-LEEQDKKALNVKEQLQR-------EHRYLKRR LEQLSLSGS----------------------------------------------------------------------V ERIR------------TDSMGSTIST-------------D-SEQ---------------EVDIEG--------------M EFTPVEAD------------------------SVDSISD----DHYSLQSSSSDTSYTATHSHRLQ-PHHC--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Homo_sapiens_MXI1 -------------------------------------------------------------------------------- ---------------------------------------------------MGKRGRPRKEARCEGAGLA---------- ----PAAPPAVPPAVAAP--QPPALPEDPAGAKPRCPFSDIFNTSENSMEKHINTFLQNVQILLEAASYLEQIE----KE NKKCEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNT----------------------------STANRSTHNE LEKN--RRAHLRLCLERLKVLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEEAERKSQHQLENLER-------EQRFLKWR LEQLQGPQE----------------------------------------------------------------------M ERIR------------MDSIGSTISS-----------DRSDSERE------------EIEVDVES--------------T EFSHGEVDN----------------------ISTTSISDID--DHSSLPSIGSDEGYSSASVKLSFTS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Pan_troglodytes_MXI1 -------------------------------------------------------------------------------- ---------------------------------------------------MGKRGRPRKEARCEGAGLA---------- ----PTAPPAVPPAAAAP--QPPALPEDPAGAKPRCPFSDIFNTSENSMEKHINTFLQNVQILLEAASYLEQIE----KE NK-------------------------------------------------------------------------STHNE LEKN--RRAHLRLCLERLKVLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEEAERKSQHQLENLER-------EQRFLKWR LEQLQGPQE----------------------------------------------------------------------M ERIR------------MDSIGSTISS-----------DRSDSERE------------EIEVDVES--------------T EFSHGEVDN----------------------ISTTSISDID--DHSSLPSIGSDEGYSSASVKLSFTS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Macaca_mulatta_MXI1 -------------------------------------------------------------------------------- ---------------------------------------------------MGKRGRPRKEARCEGAGLA---------- ----PSAPPVVPPAAAAP--QPPALPEEPAGAKPRCPFSDIFNTSENSMEKHINTFLQNVQILLEAASYLEQIE----KE NKKCEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNT----------------------------STANRSTHNE LEKN--RRAHLRLCLERLKVLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEEAERKSQHQLENLER-------EQRFLKWR LEQLQGPQE----------------------------------------------------------------------M ERIR------------MDSIGSTISS-----------DRSDSERE------------EIEVDVES--------------T EFSHGEVDN----------------------ISTTSISDID--DHSSLPSIGSDEGYSSASVKLSFTS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Mus_musculus_MXI1 -------------------------------------------------------------------------------- ---------------------------------------------------MGKRGRPRKEARCEGAGLV---------- ----PVAPPAMPPAAAAP--QPPAQPEEPAGAKPRCPFSDIFNTSENSMEKHINTFLQNVQILLEAASYLEQIE----KE NKKCEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNT----------------------------STANRSTHNE LEKN--RRAHLRLCLERLKVLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEEAERKSQHQLENLER-------EQRFLKRR LEQLQGPQE----------------------------------------------------------------------M ERIR------------MDSIGSTISS-----------DRSDSERE------------EIEVDVES--------------T EFSHGEADS----------------------VSTTSISDLD--DHSSLQSVGSDEGYSSASVKLSFAS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Rattus_norvegicus_MXI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MERVRMINVQRLLEAAEFLERR----ERE ---CEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNT----------------------------STANRSTHNE LEKN--RRAHLRLCLERLKVLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEEAERKSQHQLENLER-------EQRFLKRR LEQLQGPQE----------------------------------------------------------------------M ERIR------------MDSIGSTISS-----------DRSDSERE------------EIEVDVES--------------T EFSHGEVDN----------------------ISTTSISDID--DHSSLQSIGSDEGYSSASVKLSFTS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Canis_familiaris_MXI1 -------------------------------------------------------------------------------- ---------------------------------------------------MGKRGRPRKEARCEGAGLA---------- ----PAAP----PAVAAP--QPPAQPEEPAGAKLRCPFSDIFNTSENSMEKHINTFLQNVQILLEAASYLEQIE----KE NKKCEHGYASTFPSMPSPRLQHSKPPRRLSRAQKHSTGSSNT----------------------------STANRSTHNE LEKN--RRAHLRLCLERLKVLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEEAERKSQHQLENLER-------EQRFLKRR LEQLQGSQE----------------------------------------------------------------------M ERIR------------MDSIGSTISS-----------DRSDSERE------------EIEVDVES--------------T EFSHGEVDN----------------------ISTTSISDID--DHSSLQSIGSDEGYSSASVKLSFTS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Bos_taurus_MXI1 -------------------------------------------------------------------------------- ---------------------------------------------------MGKRGRPRKEARCEGAGLA---------- ----PAAP----PAVTAP--QPPAQPEEPAGAKLRCPFSDIFNTSENSMEKHINTFLQNVQILLEAASYLEQIE----KE NKKCEHGYASTFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNT----------------------------STANRSTHNE LEKN--RRAHLRLCLERLKVLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEEAERKSQHQLENLER-------EQRFLKRR LEQLQGPQE----------------------------------------------------------------------M ERIR------------MDSIGSTISS-----------DRSDSERE------------EIEVDVES--------------T EFSHGEVDN----------------------ISTTSISDID--DHSSLQSIGSDEGYSSASVKLSFTS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Myotis_lucifugus_MXI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------RRAHLRLCLERLKVLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEEAERKSQHQLEHLER-------EQRFLKRR LEQLQGPQE----------------------------------------------------------------------M ERIR------------MDSIGSTISS-----------DRSDSERE------------EIEVDVES--------------T EFSHGEVDN----------------------ISTTSISDID--DHSSLQSIGSDEGYSSASVKLSFTS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Monodelphis_domestica_MXI1 -------------------------------------------------------------------------------- ---------------------------------------------------MGKRGRPRKEARCGEEDGPAASSEPQTQP QPQP--------------------QPGAPVAAQLRCPFSDIFNTSESSVEKHINTFLQNVQILLEAASYLEQI----EKE NKKCEHGYASAFPSVPSPRMQHSKPPRRLSRAQKHNSGSSNT----------------------------STANRSTHNE LEKN--RRAHLRLCLERLKVLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEEAERKSQHQLENLER-------EQRFLKRR LEQLQGPQE----------------------------------------------------------------------M ERIR------------MDSIGSTISS-----------DRSDSERE------------EIEVDVES--------------T EFSHGEVDN----------------------ISTTSISDID--DHSSLQSIGSDEGYSSASVKLSFTS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Ornithorhynchus_anatinus_MXI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MVSHAHVSLTYTCFWFLSHHLCFIPLRTRFKKTSGLPGAGEFFLNRYPLLFPS RAECEHGYASTFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNT----------------------------STANRSTHNE LEKN--RRAHLRLCLERLKVLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEEAERKSQHQLENLER-------EQRFLKRR LEQLQGPQE----------------------------------------------------------------------M ERIR------------MDSIGSTISS-----------DRSDSERE------------EIEVDVES--------------T EFSHGEVDN----------------------ISTTSISDID--DHSSLQSIGSDEGYSSASVKLSFAS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Gallus_gallus_MXI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------MEQVQLINIQRLLEAAEYLERRER----- --ECEHGYASTFPSAPSPGLQDPKPTRRLSRARKHSGSGSSA----------------------------SIANRSTHNE LEKN--RRAHLRLCLERLKVLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEEVERRSQHQLENLER-------EQRFLKRR LEQLQGPQE----------------------------------------------------------------------I ERIR------------MDSIGSTISS-----------DRSDSERE------------EIEVDVES--------------T EFSHGEVDN----------------------ISTTSISDID--DHSSLQSIGSDEGYSSASVKLSFAS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Anolis_carolinensis_MXI1 -------------------------------------------------------------------------------- ---------------------------------------------------MGKRGRPRKELRGEG-------------- ---------------------------------AAAAAAAVVVEEEKDSMERINTFLQNVQILLEAASYLKQIE----KE NKKCEHGYASTFPSMPTLGLQDPKPPQRLSRARKHSSGGSST----------------------------GTANRSTHNE LEKN--RRAHLRLCLERLKVLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEDADRRSQHQLENLER-------EQRFLKRR LEQLQGSQD----------------------------------------------------------------------I ERIR------------MDSTGSTISS-----------DRSDSERE------------EIEVDVES--------------T EFSHGDVDD----------------------ISTTSTSDID--DHSSLQSIGSDEGYSSASVKLSFTS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Danio_rerio_MXI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --MVRSERQQTEVKAEDLFLESETSLDQQDFEMSTCPFNDVFNSTDS--S-MINTFLKNVQVLLEAASYIESAE----RK DGKCEHGYASTFPSIQHSSYQRQRKFRNKKCNNNHYR--------------------------------------STHNE LEKN--RRAHLRLCLERLKTLIPLGPECSRHTT-LGLLNKAKAHIKK-LEEADRKSRYQLESLER-------EQRHLRRR LDLLRDGGG----------------------------------------------S---------------------LEA ERIR------------TDSVGSTPCSERS--------DRSDSDQE------------EMEVDVES--------------T EFSHGELDS----------------------VSTASTSDLD--DHSSLQSTASDEGYSSCSIKLAFSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Takifugu_rubripes_MXI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------SESDASTDQQNFAEMSDYSLGDVLYSKCSAMD-QIGTFMRNVQVLLDAANYLENVE----KS SGKYEHGYASSYPTTRSEHHQNQRKFKNRKLDSTHNS-------------------------------------RSAHNE LEKN--RRAHLRLCLERLKSLIPLGPDCSRHTT-LGLLNKAKAHIKK-LEETDRRSQHQLETLER-------EQRHLQRQ LAQLQPHG------------------------------------------------------------------------ ERVR------------TDSLGSRVDS-----------ERSESDRE------------EIEVDVES--------------T EFSHGEMDS----------------------VSTSGASDLD--DHSSRQSSASDEGYSTCSVKVAFSA------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Tetraodon_nigroviridis_MXI1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------MSDCSLSDVLYSKCSAMD-PIGTFMKNVQVLLDAANYLENIE----KS SGKYEHGYASSYPTARSAHHQNQRKFRKGKLDSTHN--------------------------------------RSAHNE LEKN--RRAHLRLCLERLKSLIPLGPDCSRHTT-LGLLNKAKAHIKK-LEEVDRRSQHQLETLER-------EQRHLQRQ LAQLQTHG------------------------------------------------------------------------ ERVR------------MDSLGSREDS-----------DRSESDRE------------EIEVDVES--------------T EFSHGELDS----------------------VSTSGASDLD--DHSSRQSSTSDEGYSTCSLKVAFSA------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Tetraodon_nigroviridis_MXI1b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------CAFNDVFDSRDSDME-QINTFLTNVQVLLEAARFLEGTD----RK DGKCEHGYASTFPSNQNTNYQRQRKFRNKKFSSNHNR-TENPL---------------------------LCLHRSTHNE LEKNS-RRAPLRLCLERLKGLIPLGPDCTRHTT-LGLLNKAKAHIKK-LEETDRKSQYQLDSLER-------EQRHLKRQ LELLGAGGG--------------------------------------------------------------------GEG ERTR------------SDSLGSALGS-----------ERSDSDQA------------EVEVDVES--------------V EFSHGELDS----------------------ESSASTSDLD--DHSSLQSLASDEGYSSCSVKLSFPS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Gasterosteus_aculeatus_MXI1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------FFSVSKCSAMD-RIGTFTKTVQVLLDAANYLENVE----KS YGKCEHGYASTYPETQTAPQLKQRKSKNRKSDNIHN--------------------------------------RSAHNE LEKNS-RRAHLRLC-ERLKSLIPLGPDCSRHTT-LGLLNKAKAHIKK-LEELDRRSLHQLETLER-------EQRHLQRQ LSQLQTHGD----------------------------------------------------------------------R ERVC------------TDSQGSHVDS-----------G-SDRGAE------------EIEIDVES--------------T EFSHGEMDS----------------------VSTSGTSDLD--DLSSQQSSASDEGYSTCSVKLAFSA------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------- >Oryzias_latipes_MXI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------QHPLLAAPQSPPTNTEPSVLDPQDLDESSCGFNDVFDSRDPRME-QINTFLKNVHVLLEAARFLESAD----RK DGKCEHGYASTCPSDQSTSYQRTRRFRNKKFNNNHNRSSVITL---------------------------SFFFRSTHNE LEKN--RRAHLRLCLERLKALIPLGPDCTRHTT-LGLLTKAKAHIKK-LEEADRKSQNQLQSLER-------EQRHLQLQ LELLRGGGGGTQSN-----------------------------------------P---------------------GEG ERIR------------MNSVGSTLCS-----------DRSDSDQE------------EIEVDVES--------------T EFSHGELDS----------------------VSTASTSDLD--DHSSLQSMASDEGYSSCSVKLAFSS------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------