>Homo_sapiens_MAPK8 -------------------------------------------------------------------------------- -----------M--SRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVC-AAYDAILERN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IIGLLNVFTP---QKSLEEFQDVYIVMELMDANLCQVIQM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDLWSVGCIMGEMVCHKILFPGRDY---IDQWNKVIEQLGTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPD VLFPADS-EHNKLKA--SQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIP-----DKQLDER-EHT IEEWK-ELIYKEVMDLEERTKNGVIRGQPSPLG----AAVINGSQHPSSSSS-VNDVSSMSTDPT-------LASDTDSS -LEAAAG--PLGCCR---------------------------------------- >Mus_musculus_MAPK8 -------------------------------------------------------------------------------- -----------M--SRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVC-AAYDAILERN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IIGLLNVFTP---QKSLEEFQDVYIVMELMDANLCQVIQM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDLWSVGCIMGEMVCHKILFPGRDY---IDQWNKVIEQLGTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPD VLFPADS-EHNKLKA--SQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIP-----DKQLDER-EHT IEEWK-ELIYKEVMDLEERTKNGVIRGQPSPLG----AAMINGSQHPSSSPS-VNDMSSMSTDPT-------LASDTDSS -LEASAG--PLGCCR---------------------------------------- >Rattus_norvegicus_MAPK8 -------------------------------------------------------------------------------- -----------M--SRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVC-AAYDAILERN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IIGLLNVFTP---QKSLEEFQDVYIVMELMDANLCQVIQM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGEMIKGGVLFPGTDH---IDQWNKVIEQLGTPCPEFMKKL-QPTVRTYVENRPKYAGYSFERLFPD VLFPADS-EHNKLKA--SQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIP-----DKQLDER-EHT IEEWK-ELIYKEVMDLEERTKNGVIRGQPSPLG----AAVISGSQHPSSSSS-VNDVSSMSTDPT-------LASDTDSS -LEAPAG--PLGCCR---------------------------------------- >Anolis_carolinensis_MAPK8 -------------------------------------------------------------------------------- -----------M--SRSKHENNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVC-AAYDAILERN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IIGLLNVFTP---QKLLEEFQDVYIVMELMDANLCQVIQM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGEMIKGGVLFPGTDH---IDQWNKVIEQLGTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLFPD VLFPVDS-EHNKFKA--SQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIP-----DKQLDER-EHT IEEWK-ELIYNEVIELEEKTKNGIIRGQPSPLG----AAMINSSQPQSSSSS-VNDAASMSTDPT-------LISDIDSS -LETSAG--PLGCCR---------------------------------------- >Danio_rerio_MAPK8_a -------------------------------------------------------------------------------- -----------M--NKNKREKEFYSVDVGDSTFTVLKRYQNLRPIGSGAQGIVC-SAYDNNLERN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IIGLLNVFTP---QKTLEEFQDVYLVMELMDANLCQVIQM-ELDHERLSYLLYQM LCGIKHLHAAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAATGL----LMTPYVVTRYYRAPEVILG-MGYQAN- ----VDIWSVGCILAEMVRHKILFPGRDY---IDQWNKVIEQLGTPTQEFLLKL-NQSVRTYVENRPRYTGYSFEKLFPD VLFPADS-EHSKLKA--SQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPAEVEAPSPLIT-----DKQLDER-EHT VEEWK-ELIYKEVLDWEERMKNGVIRGQPSPLG---AAVINGSPQP--SSSSSINDVSSMSTEPT-------VASDTDSS -LEASAG--PLSCCR---------------------------------------- >Takifugu_rubripes_MAPK8_a -------------------------------------------------------------------------------- ------FT---M--NRNKREKEYYSIDVGDSTFTVLKRYQNLRPIGSGAQGIVC-SAYDHNLERN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IIGLLNVFTP---QKTLEEFQDVYLVMELMDANLCQVIQM-ELDHERLSYLLYQM LCGIKHLHAAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAATGL----LMTPYVVTRYYRAPEVILG-MGYQANG FTHVVDIWAVGCIMAEMVRHKILFPGRDY---IDQWNKVIEQLGTPSQEFLMKL-NQSVRTYVENRPRYAGYTFEKLFPD VLFHADS-EHNKLKA--SQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPTEVEAPPPAIT-----DKQLDER-EHT VEEWK-ELIYKEVLDWEERTKNGVIKGQPASIG----AAVSSSPQHHGSTSSSTNDVSSMSTEPT--------LTDTDSS -LEATAANASLGSCR---------------------------------------- >Oryzias_latipes_MAPK8_a --------------------------------------------------CALRVLVRQQQADGDVGIAFCERTFLEVQK S-AIEELT---M--NKNKKDKEFYSVDVGDSTFTVLKRYQNLRPIGSGAQGIVC-SAYDQTLDRN------VAIKKLSRP FQNQTHAKRAYRELVLMKYVNHKN-IIGLLNVFSP---QKSLEEFQDVYLVMELMDANLCQVIQM-ELDHERLSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAATGL----LMTPYVVTRYYRAPEVILG-MGYQAN- ----VDIWSVGCILAEMVRHKILFPGRDY---IDQWNKVIEQLGTPSQDFLMKL-NQSVRTYVENRPRYAGYTFEKLFPD VLFPADS-DHNKLKA--SQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPAEVEAPPPKIP-----DKHLDER-EHT VEEWK-DLIYKEVTEWEEWTKNGVIKGQPPPLGDTGAAVIDSPPQPTSSASSSTNDVSSMSTEPSDPSSDPTMASETDSS -LNGHTSLSMLACCR---------------------------------------- >Ciona_intestinalis_MAPK8 ------------------------------------------------------------------QADEGMSNGKNKGA NAPTGAAT---T--GKDTANTEFYTVQVSDSVFTVLKRYQSLKPIGSGAQGMVC-AAHDTVLGQH------VAIKKLSRP FQNPTHAKRAYRELVLMRAVNHKN-IIGLLNVFSP---QSSYEDFSHVYLVMELMDASLCQVIQM-DLDHERLSYLLYQL LCGIKHLHSAGIIHRD--LKPSNIVVRSDCTLK--ILDFGLARTAGGSF----MMTPYVVTRYYRAPEVILG-MGYQEV- ----VDIWSVGCIFGEMIRGQVLFPGNDH---IDQWNKITEQLGTPSEDFINKL-QPTVRNYVLNRPFQRGHPIHRLFPD SLFPADSESNGRLRS--SQARDLLAKMLVVDPIGRITVDDALQHPYIKIWYDPSEVEGPGPKVD-----GGSIDEV-DYS VEKWK-EVIWTEVKLWDTVDTTVPNPVIPLSTA-----VPDQPAEKLEPEKAESNPDVPAATAQV-------VKAETEG- ------------------------------------------------------- >Strongylocentrotus_purpuratus_MAPK8 -------------------------------------------------------------------------MAGTKLN HHQPNHHQ---F--NYHQLNSQFYHVTVGDTHFQILKRYKNLKSVGSGAQGLVV-AAYDVLTNQS------VAIKKLSRP FQNVTHAKRAYREYILMKLCNHKN-IIGLLNVFTP---QRTFDDFADIYLVMELMDASLVQVVQM-DLDHERISYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKTDCSLK--ILDFGLARTASTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSIGCIFGEMIRGQVMFPGSDH---IDQWNKIADLLGTPTDIFLSRL-QPMVKQYVENRTKCPGYSFEMLFPD ELFYQAESSTEKTKLCVAQARNLLSKMLIVDPEQRISVDEALQHPYINVWFDPGEVYGPPPIPY-----DHSIDDGGDHI LEEWK-DGTSHPIEEEKDEREHTLEQWKGF-------------------------------------------------- ------------------------------------------------------- >Apis_mellifera_MAPK8 -------------------------------------------------------------------------------- --MPYLGP---D--MTTRLSAMFYTVEVGDTRFTILKRYQNLKPIGSGAQGIVC-AAYDTVTAQN------VAIKKLSRP FQNVTHAKRAYREFKLMKLVNHKN-IIGLLNAFTP---QRSLDEFQDVYLVMELMDANLCQVIQM-DLDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKADCTLK--ILDFGLARTAGTTF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGEMIRGGVLFPGTDH---IDQWNKIIEQLGTPAQEFMQRL-QPTVRNYVENRPRYPGYPFDRLFPD VLFPSDSSEHNRLKA--SQARDLLSRMLVIDPERRISVDDALLHNYINVWYDEGEVNAPAPGPY-----DHSVDER-EHT VDQWK-ELIYQEVMEYETSHNPTTVA------------------------------QTSESGESR--------------- ------------------------------------------------------- >Hydra_magnipapillata_MAPK8 -------------------------------------------------------------------------------- ---------------------MFYSVQIGDTIFTILNRYQNLHPIGSGAQGMVCCAAYDTVIKQK------VAIKKLSRP FQNVTHAKRAFRELKLMKITNHKN-IIGLLNVFTP---DKSLEDFMDLYLVMELMDASLCQVVQM-DLDHERLSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCSLK--ILDFGLARTAGSAF----TMTPYVVTRYYRAPEIILG-MGYSEN- ----VDVWSIGCIFGEMIRGSVMFPGTDH---IDQWNKVTELLSTPPQSFFDRL-QPSVRMYCANRPKQKGYTIDELFPE DLFPVGN----KQKV--NQARDLLLKMLVVDPMKRITITQALNHPYVHVWYDAEEVEAPAPMQ-----YDHKIDEI-DHT VEEWK-AEPREIISLICFV------------------------------------------------------------- ------------------------------------------------------- >Amphimedon_queenslandica_MAPK8 -------------------------------------------------------------------------------- -------------------MADFYTTQVGDTLFTIPRRYQDLKPLGHGAQGVVC-SAKDSVRGER------IAIKKLVKP FQNETYAKRAFRELKLMKMVNHKN-VIGLLNLFSP---AHSIEDFEDVYIVMELMDANLCRVIGI-ELDHDRMSYLLYQL LCGIKHLHSAGIIHRD--LKPSNIVVKEDCSLK--ILDFGLARAADKAF----MMTPYVVTRYYRAPEVIVG-MKYKEN- ----VDIWSVGCIFAEIVRGDILLPGRDY---IDQWNKVTQILGTPPQEFFKQL-QPSVRMYCESQPRHKGKSWNELFPD DVFPNDS-KEDAHKT--RLAVDLLTKMLQIEPTRRVTVDEALKHPYVSIWYDPSEADAPPPPKY-----DHCLDEK-NIP LAQWK-KLIYEEVISFDERRDAKR-------------------------------------------------------- ------------------------------------------------------- >Homo_sapiens_MAPK9 -------------------------------------------------------------------------------- -----------M--SDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVC-AAFDTVLGIN------VAVKKLSRP FQNQTHAKRAYRELVLLKCVNHKN-IISLLNVFTP---QKTLEEFQDVYLVMELMDANLCQVIHM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTACTNF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGELVKGCVIFQGTDH---IDQWNKVIEQLGTPSAEFMKKL-QPTVRNYVENRPKYPGIKFEELFPD WIFPSES-ERDKIKT--SQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIY-----DAQLEER-EHA IEEWK-ELIYKEVMDWEERSKNGVVKDQPS-------DAAVSSNATPSQSSS-INDISSMSTEQT-------LASDTDSS -LDASTG--PLEGCR---------------------------------------- >Mus_musculus_MAPK9 -------------------------------------------------------------------------------- -----------M--SDSKSDGQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVC-AAFDTVLGIN------VAVKKLSRP FQNQTHAKRAYRELVLLKCVNHKN-IISLLNVFTP---QKTLEEFQDVYLVMELMDANLCQVIHM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTACTNF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGELVKGCVIFQGTDH---IDQWNKVIEQLGTPSAEFMKKL-QPTVRNYVENRPKYPGIKFEELFPD WIFPSES-ERDKIKT--SQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIY-----DAQLEER-EHA IEEWK-ELIYKEVMDWEERSKNG-VKDQPS-------DAAVSSKATPSQSSS-INDISSMSTEHT-------LASDTDSS -LDASTG--PLEGCR---------------------------------------- >Gallus_gallus_MAPK9 -------------------------------------------------------------------------------- -----------M--SDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVC-AAFDTVLGIN------VAVKKLSRP FQNQTHAKRAYRELVLLKCVNHKN-IISLLNVFTP---QKSLEEFQDVYLVMELMDANLCQVIHM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTACTNF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGELVKGCVIFQGTDH---IDQWNKVIEQLGTPSAEFMKKL-QPTVRNYVENRPKYPGIKFEELFPD WIFPSES-DRDKLKT--SQARDLLSKMLVVDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIY-----DAQLEER-EHA IEEWK-ELIYKEVMDWEERSKNGVVKDQPS---------------------------AQMQQ------------------ ------------------------------------------------------- >Anolis_carolinensis_MAPK9 -------------------------------------------------------------------------------- -----------M--SESKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVC-AAFDTVLGIN------VAVKKLSRP FQNQTHAKRAYRELVLLKCVNHKN-IISLLNVFTP---QKSLEEFQDVYLVMELMDANLCQVIHM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTACTNF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGELVKGCVIFQGTDH---IDQWNKVIEQLGTPSAEFMKKL-QPTVRNYVENRPKYPGIKFEELFPD WIFPSDS-DRDKLKT--SQARDLLSKMLVVDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIY-----DAQLEER-EHA IEEWK-ELIYKEVMDWEERNKNGLVKEQPS-------DAAVNSNTSPSQSSS-INDISSMSTEQT-------LASDTDSS -LDALTG--TLEGCR---------------------------------------- >Danio_rerio_MAPK9_a -------------------------------------------------------------------------------- -------A---M--TEG--EGQFYSVQVGDSTFTVLRRYQQLRAIGSGAQGIVC-SALDTVLGVP------VAVKKLSRP FQNQTHAKRAYRELVLLKCVNHKN-IIHLLNVFTP---QKSLEEFQDLYLVMELMDASLCQVIHM-DLDHERMSYLLYQI LCGIRHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTACTNF----MMTPYVVTRYYRAPEVILG-MKYKEN- ----VDIWSVGCIMGEMVKGSVIFQGTDH---IDQWNKVIEILGTPSLEFMNRL-METVRNYVMNKPQFPGVSFNELFPD WAFPSET-EHDKIKT--SQARDLLSKMLVIDPECRISVQEALNHPYIHVWYDPAEADAPPPQIS-----DKQLEER-EHS IEQWK-ELIYKEVMDWEERNKNGVLKEECL-------DGTVNSSATPSQSSS-INDISSMSTEQT-------LASDTDSS CIDTLTG--PLEDCR---------------------------------------- >Takifugu_rubripes_MAPK9_a -------------------------------------------------------------------------------- -----------M--SEE--EGHFYSVQVGDSTFTVLKRYQQLRAIGSGAQGIVC-SALDTVLGIP------VAVKKLCRP FQNQTHAKRAYRELVLLKCVNHKN-IIRLINVFTP---QKSLEEFQDLYLVMELMDANLCQVIHM-DLDHERMSYLLYQI LCGIRHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTACTNF----MMTPYVVTRYYRAPEVILG-MKYKEN- ----VDIWSVGCIMGEMVKGSVIFQGTDH---IDQWNKVIEVLGTPNLEFMNRL-METVRNYVMNKPQYPGVSFTELFPD WAFPSDS-EHDKLKTTASQARDLLSKMLVIDPECRISVEEALNHPYIHVWYDPAEADAPPPQIS-----DKQLEER-EHT IEQWK-ELIYEEVIDWEERNKNGLITGNPE-------NPSATTRR----------------------------------- ------------------------------------------------------- >Oryzias_latipes_MAPK9_a -------------------------------------------------------------------------------- -----------M--SEA--EGQFYSVQVGDSTFTVLKRYQQLRPIGSGAQGIVC-SALDTVFGIP------VAVKKLCRP FQNQTHAKRAYRELVLLKCVNHKN-IIRLINVFTP---QKSLEEFQDLYLVMELMDASLCQVIHM-DLDHERMSYLLYQI LCGIRHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTACTNF----MMTPYVVTRYYRAPEVILG-MKYKEN- ----VDIWSVGCIMGEMVKGSVIFQGTDH---IDQWNKVIEILGTPSLEFMNRL-METVRNYVMNKPQYPGVSFGELFPD WAFPSES-EHDKVKT--AQARDLLSKMLVIDPECRISVEDALNHPYIHMWYDPSEADAPPPQIS-----DKQLEER-EHT IEQWK-ELIYEEVIDWEERNKNGLMK---E-------DCSEWQE------------------------------------ ------------------------------------------------------- >Homo_sapiens_MAPK10 -------------------------------------------------------------------------------- -----------M--SKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVC-AAYDAVLDRN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IISLLNVFTP---QKTLEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGEMVRHKILFPGRDY---IDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPD SLFPADS-EHNKLKA--SQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIY-----DKQLDER-EHT IEEWK-ELIYKEVMNSEEKTKNGVVKGQPSPSG----AAVNS-SESLPPSSS-VNDISSMSTDQT-------LASDTDSS -LEASAG--PLGCCR---------------------------------------- >Mus_musculus_MAPK10 --------------------MGDTGVSGAPMKEMAQVMRIAEVTEDGRVFMSLHFLYYCSEPTLDVKIAFCQGFDKHVDV SSIAKHYN---M--SKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVC-AAYDAVLDRN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IISLLNVFTP---QKTLEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGEMVRHKILFPGRDY---IDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPD SLFPADS-EHNKLKA--SQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIY-----DKQLDER-EHT IEEWK-ELIYKEVMNSEEKTKNGVVKGQPSPSG----AAVNS-SESLPPSSS-VNDISSMSTDQT-------LASDTDSS -LEASAG--PLGCCR---------------------------------------- >Xenopus_tropicalis_MAPK10 --------------------------------------------------MSRHFLYNCSEPTLDVKIAFCQGFGNQVDV SYIAKHYN---M--SKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVC-AAYDAVLDRN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IISLLNVFTP---QKSLEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGEMVRHKILFPGRDY---IDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPD SLFPADS-EHNKLKA--SQARDLLSKMLVIDPAKRISVDEALQHPYINVWYDPSEVEAPPPQIY-----DKQLDER-EHT IEEWK-ELIYKEVMNFEEKTKNGVVKGQPSPSG----AAVNS-SESLPPSSS-VNDISSMSTDQT-------LASDTDSS -LEASAG--PLGCCR---------------------------------------- >Danio_rerio_MAPK10_a -------------------------------------------------------------------------------- -----------M--SKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVC-AGYDAVLDRN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IISLLNVFTP---QKSLEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGEMVRHKILFPGRDY---IDQWNKVIEQLGTPSPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPD CLFPADS-EHNKLKA--SQARDLLSKMLIIDPAKRISVDEALQHPYINVWYDPAEVEAPPPQIY-----DKQLDER-EHS IDEWK-ELIYKEVMNFEERTKNGVVKGQPSPSG----DVQN--------------------------------------- ------------------------------------------------------- >Takifugu_rubripes_MAPK10_a --------------------------------------------------MSRHFLYNCSQPILDVKIAFCQGFGQQVDV SYIAKHYN---M--SKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVC-AGYDAVLDRN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IISLLNVFTP---QKSLEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGEMVRHKILFPGRDY---IDQWNKVIEQLGTPSPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPD CLFPADS-EHNKLKA--SQARDLLSKMLIIDPAKRISVDEALQHPYINVWYDPAEVEAPPPQIY-----DKQLDER-EHS IDEWK-ELIYKEVMNFEERTKNGVVKGQPSPSG----AAVNS-SESPPPSSS-INDISSMSTDQT-------LASDTDSS -LETSAG--PLGCCR---------------------------------------- >Tetraodon_nigroviridis_MAPK10_a --------------------------------------------------MSRHFLYNCSQPILDVKIAFCQGFGQQVDV SYIAKHYN---M--SKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVC-AGYDAVLDRN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IISLLNVFTP---QKSLEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGEMVRHKILFPGRDY---IDQWNKVIEQLGTPSPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPD CLFPADS-EHNKLKA--SQARDLLSKMLIIDPAKRISVDEALQHPYINVWYDPAEVEAPPPQIY-----DKQLDER-EHS IDEWK-ELIYKEVMNFEERTKNGVVKGQPSPSG----AAVNS-SESLPPSSS-INDISSMSTDQT-------LASDTDSS -LETSAG--PLGCCR---------------------------------------- >Gasterosteus_aculeatus_MAPK10_a --------------------------------------------------MSRHFLYNCSQPILDVKIAFCQGFGKQVDV SYIAKHYN---M--SKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVC-AGYDAVLDRN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IISLLNVFTP---QKSLEDFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDLWSVGCIMGEMVRHKILFPGRDY---IDQWNKVIEQLGTPSPDFMKKL-QPTVRNYVENRPKYAGLTFPKLFPD CLFPADS-EHNKLKATASQARDLLSKMLIIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIY-----DKQLDER-EHS IDEWK-ELIYKEVMNFEERTKNGVVKGQPSPSG----AAVNS-SDSLAHSTY-INDISSMSTDQT-------LASDTDSS -LETSAG--PLGCCR---------------------------------------- >Oryzias_latipes_MAPK10_a --------------------------------------------------MSRHFLYNCSQPVLDVKIAFCQGFGKQVDV SYIAKHYN---M--SKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVC-AGYDAVLDRN------VAIKKLSRP FQNQTHAKRAYRELVLMKCVNHKN-IISLLNVFTP---QKSLEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGEMVRHKILFPGRDY---IDQWNKVIEQLGTPSPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPD CLFPADS-EHNKLKA?--QARDLLSKMLIIDPAKRISVDEALQHPYINVWYDPAEVEAPPPQIY-----DKQLDER-EHS IEEWK-ELIYKEVMNFEERTKNGVVKGQPSPSG----AAVNS-SESLPPSSS-INDISSMSTDQT-------LASDTDSS -LETSAG--PLGCCR---------------------------------------- >Drosophila_melanogaster_MAPK10 -------------------------------------------------------------------------------- --------------MTTAQH-QHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVC-AAYDTITQQN------VAIKKLSRP FQNVTHAKRAYREFKLMKLVNHKN-IIGLLNAFTP---QRNLEEFQDVYLVMELMDANLCQVIQM-DLDHDRMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKADCTLK--ILDFGLARTAGTTF----MMTPYVVTRYYRAPEVILG-MGYTEN- ----VDIWSVGCIMGEMIRGGVLFPGTDH---IDQWNKIIEQLGTPSPSFMQRL-QPTVRNYVENRPRYTGYSFDRLFPD GLFPNDNNQNSRRKA--SDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPY-----DHSVDER-EHT VEQWK-ELIYEEVMDYEAHNT---------------------------------------NNRTR--------------- ------------------------------------------------------- >Anopheles_gambiae_MAPK10 -------------------------------------------------------------------------------- --------------MSSRH--AFYTVEVGDTKFTILKRYQNLKPIGSGAQGIVC-AAYDTVTQQN------VAIKKLSRP FQNVTHAKRAYREFKLMKLVNHKN-IIGLLNAFTP---QRTLEEFQDVYLVMELMDANLCQVIQM-DLDHERMSYLLYQM LCGIKHLHSAGIIHRD--LKPSNIVVKSDCTLK--ILDFGLARTAGTTF----MMTPYVVTRYYRAPEVILG-MGYKEN- ----VDIWSVGCIMGEMIRGGVLFPGTDH---IDQWNKIIEQLGTPSQNFMTRL-QPTVRNYVENRPRYSGYAFDRLFPD VLFPTDSNEHNRLKA--SQARDLLSRMLVVDPEHRISVDQALVHSYINVWFDESEVNAPAPGPY-----DHSVDER-EHT VEQWK-ELIYQEVMEYEARNN-----------------------------------LADGEGAPR--------------- ------------------------------------------------------- >Nematostella_vectensis_MAPK10 -------------------------------------------------------------------------------- ---------------------MFYTAQVGDTIFIVLKRYQNLQPIGSGAQGMVC-AAIDTVTGEK------VAIKKLSRP FQNVTHAKRAFRELVLMRMVNHKN-IIGLLNVFTP---DRTLEQFNDLYLVMELMDASLCQVIHM-DLDHERLSYLLYQM LCGVKHLHDADIIHRD--LKPSNIVVKSDCSLK--ILDFGLARTAGSAF----MMTPYVVTRYYRAPEVILG-MGYCDN- ----VDVWSIGCILAEMIRGHVMFPGTDH---IDQWNKVTEQLGTPSESFLNQL-QPSVRMYCTRRPKQPGFSFEALFPD DLFPPEN----KLKA--NPTYTLIKPMYVTTQISQPYLS--INQTYVR--YDPNKPARPKHLSNLCTKYDHSIDEQ-EHS VEEWK-SK------------------------------------------------------------------------ ------------------------------------------------------- >Homo_sapiens_MAPK11 -------------------------------------------------------------------------------- ---------------MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCS-AYDARLRQK------VAVKKLSRP FQSLIHARRTYRELRLLKHLKHEN-VIGLLDVFTP---ATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQL LRGLKYIHSAGIIHRD--LKPSNVAVNEDCELR--ILDFGLARQADE------EMTGYVATRWYRAPEIMLNWMHYNQTV -----DIWSVGCIMAELLQGKALFPGSDY---IDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRG ANPLA---------------IDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPED-EPEA-EPY-----DESVEAK-ERT LEEWK-ELTYQEVLSFKPPEP------------------------------PKPPGSLEIEQ------------------ ------------------------------------------------------- >Mus_musculus_MAPK11 -------------------------------------------------------------------------------- ---------------MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCS-AYDARLRQK------VAVKKLSRP FQSLIHARRTYRELRLLKHLKHEN-VIGLLDVFTP---ATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQL LRGLKYIHSAGIIHRD--LKPSNVAVNEDCELR--ILDFGLARQADE------EMTGYVATRWYRAPEIMLNWMHYNQTV -----DIWSVGCIMAELLQGKALFPGNDY---IDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHG ANPLA---------------IDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDD-EPEA-EPY-----DESVEAK-ERT LEEWK-ELTYQEVLSFKPLEP------------------------------SQLPGTHEIEQ------------------ ------------------------------------------------------- >Anolis_carolinensis_MAPK11 -------------------------------------------------------------------------------- ---------------MSE-RGGFYKQELNKTVWEVPLRYQQLTPVGSGAYGSVCS-ACDTKTRQK------VAVKKLSRP FQSLIHARRTYRELRLLKHMKHEN-VIGLLDVFTP---ATSIENFNEVYLVTNLMGADLNNIVKCQKLTDDHIQFLIYQL LRGLKYIHSAGIIHRD--LKPSNLAVNEDCELR--ILDFGLARQTDD------EMTGYVATRWYRAPEIMLNWMHYNQTV -----DIWSVGCIMAELLKGKALFPGNDY---IDQLKRIMEVVGTPSSELLKKISSEHARKYIESLPHMPQQDLKAVFRG ANPLA---------------VDLLEKMLILDSDKRITASEALAHAYFVQYHDPDD-EPEA-ELY-----DESIENK-ERV IDEWK-ELTYGEVISFKPPD--------------------------------LKMDSLEIEQ------------------ ------------------------------------------------------- >Xenopus_tropicalis_MAPK11 -------------------------------------------------------------------------------- ---------------MSG-RVGFYKQELNKTVWEVPDRYQRLTPVGSGAFGSVCS-AYDTKTRQK------VAVKKLSRP FQSLVHARRTYRELRLLKHMKHEN-VIGLLDVFTP---STSGENFNEVYLVTNLMGADLNNIVKCQKLTDDHIQFLIYQL LRGLKYIHSAGIIHRD--LKPSNLAVNEDCELR--ILDFGLARQADD------EMTGYVATRWYRAPEIMLNWMHYNQTV -----DIWSVGCIMAELLKGKALFPGNDY---IDQLKRIMEVVGTPNSEFLLKISSEHARRYIESLPYMPQQDLKEVFHG ANPLA---------------IDLLEKMLILDSDKRITATEALAHPYFVQYHDPDD-EPEA-EPY-----DESTENK-ERT IDEWK-EITYEEVISFKSQD--------------------------------VKIDNLEIEQ------------------ ------------------------------------------------------- >Danio_rerio_MAPK11_a -------------------------------------------------------------------------------- ----------------MATRPGFYRQELNKTVWEVPERYQNLTPVGSGAYGSVCS-AYDVRLRQK------VAVKKLSRP FQSLIHSRRTYRELRLLKHMKHEN-VIGLLDVFTP---AASLEEFNEVYLVTNLMGADLNNIVKFQRLSDEHVQFLIYQL LRGLKYIHSAGLIHRD--LKPSNVAVNEDCELR--ILDFGLARQTDD------EMTGYVATRWYRAPEIMLNWMHYNQTV -----DIWSVGCIMGELLKGKVLFPGNDY---IDQLKRIMEVVGTPTPDVLKKISSEHAQKYIQSLPHMPQQDLGKIFRG ANPLA---------------VDLLKKMLVLDCDGRISASEALCHPYFSQYHDPED-EPEA-PPY-----DQTPESK-DRT MEEWK-ELVFEEVSNFKDPP--------------------------------NKPESLQVEQ------------------ ------------------------------------------------------- >Takifugu_rubripes_MAPK11_a -------------------------------------------------------------------------------- -------SSPSVCCRTMSARSGFYRQELNKTVWEVPERYQNLTPVGSGAYGSVCS-AYDVVLRQK------VAVKKLSRP FQSLIHCRRSYRELRLLKHMKHEN-VIGLLDVFTP---AAALEDFSELYLVTNLMGADLNNIVKFQKLSDEHVQFLIYQL LRGLKYIHSAGLVHRD--LKPSNVAVNEDCELR--ILDFGLARQTDD------EMTGYVATRWYRAPEIMLNWMHYNQNV -----DIWSVGCIMGELLKGKVLFPGTDY---IDQLKRIMEVVGTPTAELLKKICSEHAQKYIQSLPSMPPQDMEKIFRG ANPLA---------------VDLLKRMLILDCDGRISASEALAHPYFSQYHDPDD-EPEA-PPY-----DQSLESK-DRT LEEWK-ELIFKELSSFKVSG--------------------------------SKSDSLPVEQ------------------ ------------------------------------------------------- >Tetraodon_nigroviridis_MAPK11_a -------------------------------------------------------------------------------- GVCLSFFFFFCVGSRNMSARPGFYRQELNKTVWEVPERYQNLTPVGSGAYGSVCS-AYDVVLRQK------VAVKKLSRP FQSLIHCRRSYRELRLLKHMKHEN-VIGLLDVFTP---AAALEDFSELYLVTNLMGADLNNIVKFQKLSDEHVQFLVYQL LRGLKYIHSAGLVHRD--LKPSNVAVNEDCELR--ILDFGLARQTDD------EMTGYVATRWYRAPEIMLNWMHYNQNV -----DIWSVGCIMGELLKGKVLFPGTDY---IDQLKRIMEVVGTPTPDLLKKICSEHAQKYIQSLPFMPPQDLEKIFRG ANPLA---------------VDLLKRMLVLDCDGRISASEALAHPYFSQYHDPED-EPDA-PPY-----DQTLESK-DRT LEEWK-ELIFKEVNSFKVSS--------------------------------GKTDSLQTEQ------------------ ------------------------------------------------------- >Gasterosteus_aculeatus_MAPK11_a -------------------------------------------------------------------------------- ----------------MSARPGFYRQELNKTVWEVPERYQNLTPVGSGAYGTLCISAYDVVLRQK------VAVKKLSRP FQSLIHSRRSYRELRLLRHMKHEN-VIGLLDVFTP---AAALEDFKELYLVTNLMGADLNNIVKFQRLSDEHVQFLIYQL LRGLKYIHSAGLIHRD--LKPSNVAVNEDCELR--ILDFGLARQTDD------EMTGYVATRWYRAPEIMLNWMHYNQNV -----DIWSVGCIMGELLKGKVLFPGTDY---IDQLKRIMEVVGTPTPDLLKKICSEHAQKYIQSLPFMPQQDLEKIFRG ANPLA---------------VHLLKRMLVLDCDGRISANEALSHPYFSQYHDPDD-EPVA-PPY-----DQTLESK-DRT LEEWKVELVFEEVNCVKTSG--------------------------------NKTDSLQAEQ------------------ ------------------------------------------------------- >Apis_mellifera_MAPK11 -------------------------------------------------------------------------------- -------------------MPQFHKVEINRTEWEVPERYQMLTPVGSGAYGQVCS-ALDTKTGQK------VAIKKLARP FQSAVHAKRTYRELRMLKHMNHEN-IIGLLDVFHP---SSSLEDFQQVYLVTHLMGADLNNIVRTQKLSDDHVQFLVYQI FRGLKYIHSAGIIHRD--LKPSNIAVNEDCELK--ILDFGLARPTEN------EMTGYVATRWYRAPEIMLNWMHYNQTV -----DIWSVGCIMAELLTGRTLFPGTDH---IHQLNLIMEILGTPRDEFMQKILSESARNYIQSLPPLKKKNFKDVFRG ANPLA---------------IDLLELMLELDAEKRITAEQALAHPYLAQYADPTD-EPVS-LPY-----DQSFEDM-DLP VEKWK-ELVYHEVINFVPQQL------------------------------PTIASGIESTS------------------ ------------------------------------------------------- >Caenorhabditis_elegans_MAPK11 -------------------------------------------------------------------------------- ----MFPQTTMDHILHPTPREGYYVVELNRSVWVVPNYYINLTPIGTGAYGTVCA-AECTRSGTR------VAIKKFNRP FQSIIHARRTYRELRLLRCMCHEN-IIDLLDVFTP---NENVNDIEDVYFVSMLMGADLSNILKIQRLNDDHIQFLVYQI LRGLKYIHSADIIHRD--LKPSNIAVNEDCELK--ILDFGLARQTDS------EMTGYVATRWYRAPEIMLNWMHYTQTV -----DVWSVGCILAELITGKTLFPGSDH---IDQLTRIMSVTGTPDEEFLKKISSEEARNYIRNLPKMTRRDFKRLFAQ ATPQA---------------IDLLEKMLHLDPDRRPTAKEAMEHEYLAAYHDETD-EPIA-EEM-----DLNDDVR-ADT IDEWK-KIIWEEISDFQKNVAFA--------------------------D--EEEDEEKMES------------------ ------------------------------------------------------- >Hydra_magnipapillata_MAPK11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------MLTH-KPQT-VISLLDTFTP---QQTLEEFQDVYLVTCLMGADLNNITKVQTLTDEHVQFLVYQL LRGLKYIHSAGIIHRD--LKPGNVAVNENCELK--ILDFGLARMSDD------SMTGYVATRWYRAPEIMLNWMQYNSQV -----DIWSVGCIMAELITGKTLFPGDDH---IDQLTKIMQLVGKPTDDFLAKISSANARSYINSMPNYVRQDFDKVFPT ATAQA---------------KNILHHMLLLDPEKRFSAEQCLQHPYFSVYHDPDD-EPTA-PLF-----EEGAELN-ECS IDTIK-ALMLNEIKNFVYKP----------------------------------PPEEVME------------------- ------------------------------------------------------- >Homo_sapiens_MAPK12 -------------------------------------------------------------------------------- ------------MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCS-AVDGRTGAK------VAIKKLYRP FQSELFAKRAYRELRLLKHMRHEN-VIGLLDVFTP---DETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQM LKGLRYIHAAGIIHRD--LKPGNLAVNEDCELK--ILDFGLARQADS------EMTGYVVTRWYRAPEVILNWMRYTQTV -----DIWSVGCIMAEMITGKTLFKGSDH---LDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTN ASPLA---------------VNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTED-EPQV-QKY-----DDSFDDV-DRT LDEWK-RVTYKEVLSFKPPRQ---------------------------------LGARVSKETPL--------------- ------------------------------------------------------- >Mus_musculus_MAPK12 -------------------------------------------------------------------------------- ------------MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCS-AVDSRTGNK------VAIKKLYRP FQSELFAKRAYRELRLLKHMRHEN-VIGLLDVFTP---DESLDDFTDFYLVMPFMGTDLGKLMKHETLSEDRIQFLVYQM LKGLKYIHAAGVIHRD--LKPGNLAVNEDCELK--ILDFGLARQADS------EMTGYVVTRWYRAPEVILNWMRYTQTV -----DIWSVGCIMAEMITGKILFKGNDH---LDQLKEIMKITGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTN ASPQA---------------VNLLERMLVLDAEQRVTAAEALTHPYFESLRDTED-EPKA-QKY-----DDSFDDV-DRT LEEWK-RVTYKEVLSFKPPRQ---------------------------------LGARVPKETAL--------------- ------------------------------------------------------- >Gallus_gallus_MAPK12 -------------------------------------------------------------------------------- ---------------MSSPKNGFYQQEITKTLWEVRDRYRDLQPVGSGAYGTVCS-AVDGRSGAK------VAIKKLYRP FQSQILAKRAYRELRLLKHMKHEN-VIGILDVFTP---DVTLEKFNGFYLVMPFMGTDLSKIMKHEKLTEDRIQFLVYQI LKGLKYIHSSGIIHRD--LKPGNLAVNEDCELK--ILDFGLARHTDS------EMTGYVVTRWYRAPEVILNWMHYTQTV -----DIWSVGCIMAEMITGRPLFRGNDH---LDQLTEIMKITGTPSQDFVQKLKSQDAKNYIKSLPKVQKKDFASVLKH ASPLA---------------VNLLENMLVLDAEERVTAAEALMHPYFEPIHDPEE-EIEA-EKY-----DDTFDNM-DLP LDEWK-RITYKEILNFKPPQT---------------------------------SES---KETASMDLQ----------- ------------------------------------------------------- >Anolis_carolinensis_MAPK12 -------------------------------------------------------------------------------- ---------------MSSPKKGFYRQEIAKTVWEVRERYRELQAVGSGAYGAVCS-ATDRKSGTK------VAIKKLYRP FQSDLFAKRAYRELRLLKHMKHEN-VIGLLDVFTP---DASLDKFNDFYIVMPFMGTDLSKIMKHEKLTEDRIQFLVYQM LKGLKYIHSSGIIHRD--LKPGNLAVNEDCELK--ILDFGLARHTDS------EMTGYVVTRWYRAPEVILNWMHYTQTV -----DIWSVGCIMAEMITGRPLFKGNDH---LDQLTEIMKVTGTPTQDFVQKLQSQDAKNYIKSLPKVQKKDFAAILKY ATPLA---------------VNLLEKMLVLDAEKRISAAEALAHPYFEAIHDPEE-ETEA-EKY-----DETFDNM-DLP LDEWK-CITYKEVINFNPPPS---------------------------------PES---KETAV--------------- ------------------------------------------------------- >Xenopus_tropicalis_MAPK12 -------------------------------------------------------------------------------- ------------MSTSPLPKKGYYRQDVNKTVWEVKERYRDLVAVGSGAYGTVCS-SLDTRTGTK------VAIKKLYRP FQSELFAKRAYRELRLLKHMQHEN-VIGLLDVFTP---DSTLENFNDFYLVMPFMGTDLGKIMKHEKLSEDRIQFLVYQI LRGLKYIHSAGIIHRD--LKPGNLAVNEDCELK--ILDFGLARHTDS------EMTGYVVTRWYRAPEVILNWMHYTQTV -----DIWSVGCIMAEMYTGRPLFKGNDHK-DLDQLTEIMKITGTPTQDFVQKLQSPDAKNYIKSLPKVQKKDFGSLLRY ANPLA---------------VNILEKMLVLDAEKRITATEALAHPYFEQFHDIDD-ETEA-EPY-----DDSFDNV-NLP LEEWR-RLTHKELTSYKP-LV---------------------------------ADS---KETSV--------------- ------------------------------------------------------- >Danio_rerio_MAPK12_a -------------------------------------------------------------------------------- --------------MTARSRPGYFRQEINKTIWEVPDRYKDLKQVGTGAYGTVCY-ALDRRTGAK------VAIKKLHRP FQSDLFAKRAYRELRLLKHMKHDN-VIGLVDVFTA---DLSLDRFHDFYLVMPFMGTDLGKLMKMERLSEERVQYLVYQM LKGLKYIHAAGIIHRD--LKPGNLAINEECELK--ILDFGLARQTDS------EMTGYVVTRWYRAPEVILSWMHYTQTV -----DIWSVGCIMAEMLLGKPLFKGHDH---LDQLMEIMKVTGTPSKEFTAKLQSEDARNYVTKLPRFRKKDLRILLPN VNPQA---------------IKVLDGMLLLDPESRITAAEALAFPFFSEFREPEE-ETEA-PPY-----DHSLDEA-DQS LEQWK-RLTFTEILTFQPA-P---------------------------------AVAE-SKETAL--------------- ------------------------------------------------------- >Danio_rerio_MAPK12_b -------------------------------------------------------------------------------- --------------MSLRSRAGFYRQEINRTVWDVPERYRDLIQIGTGAYGTVCS-AIDRKTGVR------VAIKKLHRP FQSRLFAKRAYRELRLLKHMKHEN-VIGLLDVFTS---EILLDRFHDFYLVMPFMGTDLGKLMKMERLCEDRVQFLVYQI LRGLKYIHSAGIIHRD--LKPGNLAVNQNCELK--ILDFGLARQADS------EMTGYVVTRWYRAPEVILNWMHYSQTV -----DIWSVGCIMAEMLLGRTLFKGNDH---LDQLREIMKITGTPAPDFITKLQSQDAKNYIRGLPKVPKKDLNTIFFK ASSEA---------------VSALELMLVLDPDKRVSAAEALELPLFTEFREPEE-ETEA-LPY-----DHSMDNT-ELP LDQWK-RHTFTEILSFQPPVT---------------------------------EIRD-SKETSL--------------- ------------------------------------------------------- >Takifugu_rubripes_MAPK12_a -------------------------------------------------------------------------------- ------------STMSKRVRPGYYRQDINKTKWEVPERYRDLRQVGTGAYGTVCS-AVDNRTGSK------VAIKKLYRP FQSELFAKRAYRELRLLKHMKHEN-VIGLLDVFTA---DLSLDAFNDFYLVMPFMGTDLGKLMKIQRLSEEKIQYLVYQM LKGLKYIHSAGIIHRD--LKPGNLAINQDCELK--ILDFGLARQADS------EMTGYVVTRWYRAPEVILSWMHYTQTV -----DIWSVGCIMAEMLQGKPVFKGSDH---LDQLNEIMKITGTPTQEFVTKLDSEDARRYIKGLPKIEKKDLQKVFST TNPQA---------------VSVLDRMLLLDPESRATAAEALALPYFTEFREPEE-ETEA-QLY-----DHSLDNA-DLP LSQWK-RHTFTEILTFK---P---------------------------------VVSE-SKETPL--------------- ------------------------------------------------------- >Takifugu_rubripes_MAPK12_b -------------------------------------------------------------------------------- --------------MALRSRTGFYRQEVNRTVWEVPERYRDLRQIGTGAYGTVCS-AWDRRSGSQ------VAIKKLQRP FQSKLFAKRAYRELRLLKHMKHEN-VIGLLDVFTA---EV-LDRLRDFYLVMPFMGTDLGKLMKVERLTEERVQFLVYQM LRGLKYIHSAGIIHRD--LKPGNLAINPDCELK--ILDFGLARQADA------EMTGYVVTRWYRAPEVILNWMHYTQTV -----DIWSAGCIMAEMLLGRPLFKGNDH---LDQLREIMKVTGTPTGDFVVKLRSQDAKNYIRSLPKVPKKDLHSIFSK SSSNA---------------VCVLEKMLLLDPEERVSASEALDLDFFSEFRDVDE-ETEA-LPY-----DQTLDNT-DLQ LDQWK-RHTFTEILTFRPA-------------------------------------R----ETPL--------------- ------------------------------------------------------- >Tetraodon_nigroviridis_MAPK12_a -------------------------------------------------------------------------------- ------ARFLIFFAMSKRVRPGFHRQDINKTKWEVPERYRDLRQVGTGAYGTVCS-AVDIRTGSK------VAIKKLYRP FQSELFAKRAYRELRLLKHMKHEN-VIGLLDVFTS---DFSLDAFDDFYLVMPFMGTDLGKVMKMQRLSEEKIQYLVYQM LRGLKYIHSAGIIHRD--LKPGNLAINQDCELK--ILDFGLARQTDS------TMTGYVVTRWYRAPEVILSWMHYTQTV -----DIWSVGCIMAEMLQGKPLFKGSDH---LDQLNEIMKITGTPTQEFVAKLDSEDARRYIKGLQKIEKKDLQTVFST TNPQA---------------VSVLERMLLLDPESRASAAEALALPYFSEFRDPEE-ETEA-QPY-----DHSLDNA-DLP LSQWK-RHTFTEILSFK---P---------------------------------VVSE-FKETPL--------------- ------------------------------------------------------- >Gasterosteus_aculeatus_MAPK12_a -------------------------------------------------------------------------------- --------------MSKRIRPGYYRQDVNKTSWEVPERYRELKQVGTGAYGTVCS-AVDSRTGTK------VAIKKLYRP FQSELFAKRAYRELRLLKHMKHEN-VIGLFDVFTA---DLSLDKFHDFYLVMPFMGTDLGRLMKLQRLSEDKIQYLVYQM LKGLKYIHSSGIIHRD--LKPGNLAINQDCELK--ILDFGLARQADS------EMTGYVVTRWYRAPEVILSWMHYTQTV -----DIWSVGCIMAEMLQGKPLFKGSDH---LNQLTEIMKVTGTPTQEFAAKLVSDDARGYVKSLPKVEKKDLHSVFST TNPQA---------------VAVLERMLLLDPESRVSAEEALMLPYFTEFREPEE-ETVP-QQY-----DHSLDNT-DQS LAQWK-RHTFTEILTFK---P---------------------------------VVPD-SKETALGLKIT---------- ------------------------------------------------------- >Gasterosteus_aculeatus_MAPK12_b -------------------------------------------------------------------------------- ---------LSRCGMAVRSRTGYYRQEVNRTGWEVPERYRDLKQVGTGAYGTVCS-AWDRRLGAQ------VAIKKLHRP FQSKLFAKRAYRELRLLKHMKHEN-VIGLLDVFTA---EIALDRLRDFYLVMPFMGTDLGKLMKLERLSEDRVQFLVYQM LRGLKYIHSAGIIHRD--LKPGNLAINPDCELK--ILDFGLARQADA------EMTGYVVTRWYRAPEVILNWMRYTQTV -----DIWSAGCIMAEMLLGRPLFKG--N---LDQLREIMKITGTPAADFVVKLQSQDAKNYIRSLPKVPKKDLQSVFSK ASSNA---------------VCVLEKMLLLDPEQRANASEALDLPFFAEFRDTEE-ETEA-QPY-----DQTMDNT-DLP LDQWK-RHTFTEILTFRPP-------------------------------------RD-SRETSL--------------- ------------------------------------------------------- >Oryzias_latipes_MAPK12_a -------------------------------------------------------------------------------- ------------TKMSLRVRPGYSRQEVNKTSWEVPDRYRDLKQVGSGAYGTVCS-ATDSRTGAK------VAIKKLYRP FQSEIFAKRAYRELRLLKHMKHEN-VIGLLDVFTA---DLSLDRFLDFYLVMPFMGTDLGKLMKMHKLSEDKIQYLVYQM LKGLKYIHSAGIIHRD--LKPGNLGINQDCELK--ILDFGLARQTDS------EMTGYVVTRWYRAPEVILSWMHYTQTV -----DIWSVGCIMAEMLQGKPLFKGNDH---LDQLTEIMKITGTPSPEFLSKLVSEEAKKYLKSLPKQEKKDLQKVFPS SDVHA---------------VSMMEKMLLLDPEKRVTAAEALTLPYFTEFRDSEE-EKEA-QPY-----DHSLDNA-ELS VDQWK-RHTFTEILTFK---P---------------------------------VLPD-SKETSL--------------- ------------------------------------------------------- >Oryzias_latipes_MAPK12_b -------------------------------------------------------------------------------- ------------MAIAARSRSGFYRQEVNRTVWEVPERYRDLKQIGTGAYGTVCS-AWDRRTGAQ------VAIKKLHRP FQSKLFAKRAYRELRLLKHMRHEN-VIGLLDVFTA---EISLDRFRDFYLVMPFMGTDLGKLMKMEKLTEDRVQFLVYQI LKGLKYIHSAGIVHRD--LKPGNLAINPDCELK--ILDFGLARQADA------EMTGYVVTRWYRAPEVILNWMHYTQTV -----DIWSAGCIMAEMLLGKPLFKGSDH---LDQLREIMKITGTPSPDFVVKLQSQDAKNYIRSLPKVPKKDLHYIFSK ASSNA---------------VCVLERMLLLDPECRASASEALELPFFNEFRDIEE-ETEA-LPY-----DQTMDNT-DLP LDQWK-RHTFTEILTFRPP-------------------------------------RD-SKGTSL--------------- ------------------------------------------------------- >Homo_sapiens_MAPK13 -------------------------------------------------------------------------------- --------------MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCS-AIDKRSGEK------VAIKKLSRP FQSEIFAKRAYRELLLLKHMQHEN-VIGLLDVFTP---ASSLRNFYDFYLVMPFMQTDLQKIMGM-EFSEEKIQYLVYQM LKGLKYIHSAGVVHRD--LKPGNLAVNEDCELK--ILDFGLARHADA------EMTGYVVTRWYRAPEVILSWMHYNQTV -----DIWSVGCIMAEMLTGKTLFKGKD---YLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR ASPQA---------------ADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEE-ETEAQQPF-----DDSLEHE-KLT VDEWK-QHIYKEIVNFSPIAR---------------------------------KDSRRRSG-MKL-------------- ------------------------------------------------------- >Mus_musculus_MAPK13 -------------------------------------------------------------------------------- --------------MSLTRKRGFYKQDINKTAWELPKTYLAPAHVGSGAYGAVCS-AIDKRTGEK------VAIKKLSRP FQSEIFAKRAYRELLLLKHMHHEN-VIGLLDVFTP---ASSLRSFHDFYLVMPFMQTDLQKIMGM-EFSEDKVQYLVYQM LKGLKYIHSAGIVHRD--LKPGNLAVNEDCELK--ILDFGLARHTDT------EMTGYVVTRWYRAPEVILSWMHYNQTV -----DIWSVGCIMAEMLTGKTLFKGKD---YLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPR ASPQA---------------ADLLDKMLELDVDKRLTAAQALAHPFFEPFRDPEE-ETEAQQPF-----DDALEHE-KLS VDEWK-QHIYKEISNFSPIAR---------------------------------KDSRRRSG-MKLQ------------- ------------------------------------------------------- >Gallus_gallus_MAPK13 -------------------------------------------------------------------------------- --------------MNFTRRRGFYRQELNRTIWELPRRYTSLHPVGSGAYGSVCS-AIDKKTGEK------VAIKKLCRP FQSEIFAKRAYRELTLLKQMQHEN-VIGLLDVFTS---APSYHGFQDFYLVMPYMRTDLQKIMGH-EFSDEKIQYLVYQM LKGLKYIHSAGIIHRD--LKPGNLAVNEDCQLK--ILDFGLARHADA------EMTGYVVTRWYRAPEVILNWMHYNQTV -----DIWSIGCIMAEMLTGKTLFKGKD---YVDQLTQILKVTGHPGDDFVEKLEDKAAKSYIKSLPKMPKKDLSVLFPT ANPQA---------------VDLLDKMLQLDVEKRLTATEALAHPYFDQFRDIEE-ETEAQQSY-----DDSLERE-KLS IEEWK-KHIYKEILSFSPIAQ---------------------------------KDSKKRSG-MSL-------------- ------------------------------------------------------- >Anolis_carolinensis_MAPK13 -------------------------------------------------------------------------------- --------------MSFSRRRGFYKQEVNKIVWELPRRYTSIVSVGSGAYGSVCS-SIDKKTGEK------VAIKKLCRP FQSEIFAKRAYRELTLLKHMQHEN-VIGLLDVFTS---ATSFEGFQDFYLVMPYMQTDLQKIMGH-QFSEEKIQYLIYQV LKGLKYIHSAGIIHRD--LKPGNLAVNEDCALK--ILDFGLARHTDT------EMTGYVVTRWYRAPEVILNWMHYNQTV -----DIWSVGCIMAEMLTGKTLFKGKD---YLDQLTLILKVTGSPGEEFIQKLEDKAAKSYIQTMPKIPKMDLSRLFPR ASPLA---------------VDLLDKMLQLDVEKRLTATQALAHPYFEPFRDVEE-ETEAQHSY-----DDSVGAQ-KLS INEWR-RHIYNEILTFSPIAR---------------------------------KDSKRRSG-MTL-------------- ------------------------------------------------------- >Xenopus_tropicalis_MAPK13 -------------------------------------------------------------------------------- --------------MSSSVKCKFRKEEVNKTLWEIPLRYASLCLVGSGAYGSVCS-AIDLKTGEK------VAIKKLSRP FQSEIFAKRAFRELTLLKHMNHEN-VIGLLDVFTS---ATSFNDFHNFYLVMPYMQIDLQKIMGH-HLSEDKVQYLVYQM LCGLKYIHAAGIIHRD--LKPGNLAVNEDCELK--ILDFGLARHADA------EMTGYVVTRWYRAPEVILNWMHYNKTV -----DIWSVGCIMGEMLTGKTLFKGKDCILDLDQLTQILKVTGVPGPEFIQKLEDMAAKKYIQSLPKIPKKEFSLLFPN ASDLA---------------VDLLEKMLELDVEKRLTATEALEHPYFDEFHDADE-ETEA-PPY-----DDSLEGE-KLS VEEWR-KYTYEEVINYTPILR---------------------------------KDSKRKSG-MSIKDEFEGTCPLP--- ------------------------------------------------------- >Danio_rerio_MAPK13_a -------------------------------------------------------------------------------- ----------------MESRVEFSREEINSTVWEVPAKYVCLKQIGTGAYGSVCS-SINNKTKEK------VAIKKLHRP FQSEIFAKRAYRELRLLKHMKHEN-VIGLLDVFTP---ATRLDEFQDFYLVMPYMYTDLSKVKG--LLTEDRIQFLVYQM LCGLKYIHGAGIIHRD--LKPGNLAVNQDCELK--ILDFGLARHTDA------EMTGYVVTRWYRAPEVILNWMHYTQTV -----DIWSVGCIMGEMFNGKTLFKGKD---YMDQLTQIMKVAGTPGPEFVEKLESPEAKSYVRSLPHYPHRDFSTLFPR ASKKA---------------VELLEKMLVLDADARLTASGALAHSYFDGLRDPDD-WPEP-TAY-----DDSYDNA-TLP LEEWK-RLSFKEVRSFVPFPR---------------------------------RDSKRRNT-LTMS------------- ------------------------------------------------------- >Takifugu_rubripes_MAPK13_a -------------------------------------------------------------------------------- --------------CIMEAHAHFSREEINNTVWEVPEKYTRLKQIGTGAYGSVCS-TINEKTKEK------VAIKKLHRP FQSEIFAKRAYRELRLLKHMKHEN-VIGLLDVFTP---ALGLDEMQDFYLVMPYMFTDLSKVRG--PLSEDKVQFLIYQT LCGLRYIHKAGIIHRD--LKPGNLAVNQDCELK--ILDFGLARSADA------EMTGYVVTRWYRAPEVILNWMHYTQTV -----DIWSVGCIMAEMIHGKTLFKGKD---YMDQLTQIMKVTGVPGPEFIQKLDSIEAKNYVKALPRYPRKDFSTLFPK ASAKG---------------IDLLEKMLVLDGDERLTAELALEHSYFDSLRDPDD-FPEP-TPY-----DDSHDNA-TLS LDEWK-RLCFREVKSFVPFPR---------------------------------RDSKRKNT-LTMS------------- ------------------------------------------------------- >Tetraodon_nigroviridis_MAPK13_a -------------------------------------------------------------------------------- ----------ASSPLVMEAHAHFSREEINNTVWEVPEKYTRLKQIGTGAYGSVCS-AINERTKEK------VAIKKLHRP FQSEIFAKRAYRELRLLKHMKHEN-VIGLIDVFTP---ASGLDEMQDFYLVMPYMFTDLSKVRG--PLSEDKVQFLIYQT LCGLRYIHKSGIIHRD--LKPGNLAVNQDCELK--ILDFGLARSADA------EMTGYVVTRWYRAPEVILNWMHYTQTV -----DIWSVGCIMAEMINGKTLFKGKD---YMDQLTQIMKVTGVPGPEFVQKLDSIEAKNYVKALPRYPRKDFSTLFPK ASANG---------------IDLLEKMLVLDGDERLTADLALEHPYFDSLRDADD-FPEP-TPY-----DDSHDNA-TLS LDEWK-RLCFREVKSFVPFPR---------------------------------RDSKRKNTPYNVSL------------ ------------------------------------------------------- >Gasterosteus_aculeatus_MAPK13_a -------------------------------------------------------------------------------- ------------ILLTMEARAHFYREEINNTAWEVPEKYTRLKQIGTGAYGSVCS-AINEKTKEK------VAIKKLHRP FQSEIFAKRAYRELRLLKHMKHEN-VIGLLDVFSS---ASSLDDMQDFYLVMPYMFTDLSKVRG--HLTEDKVQFLVYQM LCGLRYIHKAGIIHRD--LKPGNLAVNQDCELK--ILDFGLARSTDA------EMTGYVVTRWYRAPEVILNWMHYTQTV -----DIWSVGCIMAEMINGKTLFKGRD---YMDQLTQIMKVTGVPGAEFTQKLDSQEAKNYIKALPRYPRKDFSTLFPR ASAMG---------------IDLLEKMLVLDGDERPTAELALEHPYFDSLRDLED-LPPP-APY-----DDSHDNA-TLS LDEWK-RLCFKEVRSFVPFPR---------------------------------RDSKRKNT-LTMSP------------ ------------------------------------------------------- >Oryzias_latipes_MAPK13_a -------------------------------------------------------------------------------- ------------LLFIMDAKTHFTREEINSTVWEVPEKYTLLKQVGTGAYGSVCS-AINGKTKEK------VAIKKLHRP FQSEIFAKRAYRELRLLKHMKHEN-VIGLLDVFTL---ACCLDEFQDFCLVMPYMYTDLSKVRG--SLSDDKVQFLVYQM LCGLRYIHKAGIIHRD--LKPGNLAVNPDCQLK--ILDFGLARSTDA------EMTGYVVTRWYRAPEVILNWMHYTQTV -----DIWSVGCIMGEMINGKTLFKGKD---YMDQLTQILKVTGVPGPEFVQKLDSPEAKTYVKNLPRYPRKAFSSLFPK ASELA---------------IDLLEKMLVLDGDERPTAEIALEHQYFDSLRDPDD-LPEP-VPY-----DDSHDNA-TLS LDEWK-RLCFKEVKSFVPFPR---------------------------------RDSKRKNT-LTMSS------------ ------------------------------------------------------- >Homo_sapiens_MAPK14 -------------------------------------------------------------------------------- --------------MSQ-ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCA-AFDTKTGLR------VAVKKLSRP FQSIIHAKRTYRELRLLKHMKHEN-VIGLLDVFTP---ARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQI LRGLKYIHSADIIHRD--LKPSNLAVNEDCELK--ILDFGLARHTDD------EMTGYVATRWYRAPEIMLNWMHYNQTV -----DIWSVGCIMAELLTGRTLFPGTDH---INQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIG ANPLA---------------VDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDD-EPVA-DPY-----DQSFESR-DLL IDEWK-SLTYDEVISFVPPP----------------------------------LDQEEMES------------------ ------------------------------------------------------- >Mus_musculus_MAPK14 -------------------------------------------------------------------------------- --------------MSQ-ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCA-AFDTKTGHR------VAVKKLSRP FQSIIHAKRTYRELRLLKHMKHEN-VIGLLDVFTP---ARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQI LRGLKYIHSADIIHRD--LKPSNLAVNEDCELK--ILDFGLARHTDD------EMTGYVATRWYRAPEIMLNWMHYNQTV -----DIWSVGCIMAELLTGRTLFPGTDH---INQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLAQMPKMNFANVFIG ANPLA---------------VDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDD-EPVA-DPY-----DQSFESR-DLL IDEWK-SLTYDEVISFVPPP----------------------------------LDQEEMES------------------ ------------------------------------------------------- >Gallus_gallus_MAPK14 -------------------------------------------------------------------------------- -----------AAEMSQ-ERPKFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCS-AFDTKTGLR------VAVKKLSRP FQSIIHAKRTYRELRLLKHMKHEN-VIGLLDVFTP---AKSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQI LRGLKYIHSADIIHRD--LKPSNLAVNEDCELK--ILDFGLARHTDD------EMTGYVATRWYRAPEIMLNWMHYNQTV -----DIWSVGCIMAELLTGRTLFPGTDH---IDQLKLILRLVGTPGPELLKKISSESARNYIQSLSYMPKMNFENVFIG ANPLA---------------VDLLEKMLVLDTDKRITAAEALAHAYFAQYHDPDD-EPVA-DPY-----DQSFESR-ELE IEEWK-SLTYDEVISFVPPP----------------------------------LDQEEMES------------------ ------------------------------------------------------- >Anolis_carolinensis_MAPK14 -------------------------------------------------------------------------------- --------------MTQ-ERPKFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCS-AFDTKTGLR------VAVKKLSRP FQSIIHAKRTYRELRLLKHMKHEN-VIGLLDVFTP---AKSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQI LRGLKYIHSADIIHRD--LKPSNLAVNEDCELK--ILDFGLARHTDD------EMTGYVATRWYRAPEIMLNWMHYNQTV -----DIWSVGCIMAELLTGRTLFPGTDH---IDQLKLILRLVGTPGPELLKKISSESARNYIQSLSYMPKMNFENVFIG ANPLA---------------VDLLEKMLVLDTDKRITAAEALAHTYFAQYHDPDD-EPVA-DPY-----DQSFESR-ELD IEEWK-SLTYDEVVSFVPPP----------------------------------LDQEEMES------------------ ------------------------------------------------------- >Oryzias_latipes_MAPK14_a -------------------------------------------------------------------------------- --SVGEVGAVVSAGMSQKERPNFYRQEVNKTIWEVPDRYQNLSPVGSGAYGSVCS-AYDTKTGLK------VAVKKLSRP FQSIIHAKRTYRELRLLKHMKHEN-VIGLLDVFTP---ATSLKEFTDVYFVNHLMGADLNNIVKCQKLTDDHVQFLIYQI LRGLKYIHSADIIHRD--LKPSNLAVNEDCELK--ILDFGLARLTDD------EMTGYVATRWYRAPEIMLNWMHYNMTV -----DIWSVGCIMAELLTGRTLFPGTDH---IDQLKLIMMLVGTPGPELLMKISSESARTYISSLPHMAKRNFADVFIG ANPLD-K------------AVDLLEKMLVLDTDRRITAAEALEHPYFAQYHDPDD-EPEA-EPY-----DQSFESR-DLN IKEWK-RLTYEELCSFEPPV----------------------------------FN------------------------ ------------------------------------------------------- >Oryzias_latipes_MAPK14_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------MLHRN-VIGLLDVFTP---ATSLDEFSDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQI LRGLKYIHSAGIVHRD--LKPSNLAVNEDCELK--ILDFGLARHTDD------EMTGYVATRWYRAPEIMLNWMHYNMTV -----DIWSVGCIMAELLTGRTLFPGTDH---IDQLKLIMMLVGTPGPELLMKISSEPARNYINSLPHMPKRNFADVFIG ANPL---------------AVDLLEKMLVLDTDKRITASEALAHPYFAQYHDPDD-EPEA-EPY-----DQSFESR-ELE IEEWR-SLIYDEVLSFEPPS----------------------------------LDGDEMES------------------ ------------------------------------------------------- >Ciona_savignyi_MAPK14 -------------------------------------------------------------------------------- -------KHKMAGPLNNMADREFNHYELNKTDWEVPSKYEDLVPIGCGAYGSVCS-TLNSQLKMR------MAVKKLARP FQSVTHAKRTYRELRLLKHMHHEN-VIGLLDVFTP---ASSIENFTDMYLVTHLMGADLNQIIKSQKLTDDHVQFLIYQI LRGLKYIHSAGIIHRD--LKPSNIAVNEDCELK--ILDFGLARLTDD------QMTGYVATRWYRAPEIMLNWMHYNQTV -----DIWSVGCIMAELLTGQTLFPGSDH---IDQLKSIMTLCGTPRDDLLEKIISQSARNFIKNLPIIPKKEFINVFVG ANPKA---------------VDLLERMLVLDTDCRLTASEALQHPYLEKFHDPED-EPTA-PLY-----DKTYEDA-EIS IDEWK-QLAYDEIVNFKFSP------------------------------------DLITDY------------------ ------------------------------------------------------- >Drosophila_melanogaster_MAPK14 -------------------------------------------------------------------------------- --------------MSRKMAK-FYKLDINRTEWEIPETYQNLQPVGQGAYGQVCK-AVVRGTSTK------VAIKKLARP FQSAVHAKRTYRELRLLKHMDHEN-VIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQKLSDDHVQFLVYQI LRGLKYIHSAGVIHRD--LKPSNIAVNEDCELR--ILDFGLARPAES------EMTGYVATRWYRAPEIMLNWMHYNQTA -----DIWSVGCIMAELLTGRTLFPGTDH---IHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPVMPRRNFRDIFRG ANPLA---------------IDLLEKMLELDADKRITAEQALAHPYMEKYHDPTD-EQTA-ALY-----DQSFEEN-ELP VEKWR-EMVFSEVTAFKPT--------------------------------AAFAELLPKEQ------------------ -------------------------------------------------------