>Homo_sapiens_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESERSKRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIVRT-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Pan_troglodytes_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESERSKRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIVRT-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQSFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Gorilla_gorilla_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESERSKRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIVRT-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Pongo_abelii_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESERSKRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIVRT-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIK----------------------- ------KTEFSF-------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Macaca_mulatta_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESERSKRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIVRT-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Callithrix_jacchus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESERSKRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVTSLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDAFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIVRT-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFSNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRIPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VFNWDSEKAT---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Mus_musculus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESESSRRMGN----ACIPLKRIAYFLCLFSVVLLT---EGKKPAKPK------------------------- --------------CPAVCT-CSKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNAFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSPKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIDTQLYVIVAQLFGGSHIYKRDGFAN---------------KFIKIQDIEVLKIRKPNDIE TFKIED------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIARP-------PLALRTPHLILSSSSQRPVIYQWSKA------TQLFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Rattus_norvegicus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESESIRRMGN----ACIPLKRIAYFLCLFSVVLLT---EGKKPAKPK------------------------- --------------CPAVCT-CSKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSPKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIDTQLYVIVAQLFGGSHIYKRDGFAN---------------KFIKIQDIEVLKIRKPNDIE TFKIED------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIARP-------PLTLRTPHLILSSSSQRPVIYQWSKA------TQLFINQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Oryctolagus_cuniculus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESERSQRMGN----ACLPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLSHT-------NATVEDIYCEGP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDGFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIART-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFLDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Canis_familiaris_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESERSQRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSPKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIART-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Felis_catus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESERSQRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSPKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIART-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Bos_taurus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------SLLHWSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLSHT-------NATVEDIYCEGP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIART-------PQTLRTPHLILSSSSQRPVIYQWNKA------IQLFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Equus_caballus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------M QDGSLLQQLDPSHLAAPHRSLPRAVHCWSEEQLTNQLQVPVLKSRDTEAKEKGGLLCDLV----LEQDNHHLNSRSPVHV WGYFFDCMESERSQRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIARM-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFINQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Loxodonta_africana_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MEAERSQRMGN----ACVPLKRIAYFLCLLSALLLT---EGKKPTKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLDHT-------NATVEDIYCEGP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDGFAN---------------KFIKIQDIEILKIRKPNDIE TFNIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIART-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGASFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDADKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Dasypus_novemcinctus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESERSQRMGN----ACIPLKRIAYFLCLFSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLT-V--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLDHT-------NATVEDIYCEGP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVIADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIART-------PQTLRTPHLILSSSSQRPVIYQWNKA------MQLFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFLDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Myotis_lucifugus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESERSQRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCESP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQEL PYQSLS-IDTFSYM--NDEYVVIAQ------------PFNGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDGFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIART-------PQALRMPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Pteropus_vampyrus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------KESERSQRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YD-ITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIART-------PQALRTPHLILSSSSQRPVIYQWNKA------TQLFINQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFTRVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Monodelphis_domestica_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------MNFSGLGL----RARQSPSESRSFLFML GEIFFNWMEAEKIKRMGSPSSASSIPLKRIAYFLCFLSMLLLT---EGKKPTKPK------------------------- --------------CPALCT-CTKDNALCENARS--IPRSVPPDVISLSFVRSGFTEILEGSFLLTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHSFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLDTT-------NATVEEIYCENP PEYKKRKIRSLSSKDFDCIIT---------------------------------------------------EFAASQLL PYQSLS-IDTFTYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTVYKWNGN----------------------------- --GFYSHQSLHQWYRDTDVEYLEIART-------PQTAKTPHLILSSSSQRPVIYQWNKS------TKLFTNQTDIPNME DVYAV-KHFTVKGEVYICLTR---FIGDSKVMKW--GGSSFVDVQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---IQAPRSFTHVAIN----------------------- ------KHNFLFASSFKGRTQIYTHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Erinaceus_europaeus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------MESERSQRMGN----ACMPLKRIAYFLCLLSALLLT---EGKKPAKPK------------------------- --------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP PEYKKRKINSLSPKDFDCIIT---------------------------------------------------EFAKSQDL PYQSLS-IDVFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT--------- ----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIART-------PQILRTPHLILSSSSQRPVIYQWNKA------TQLFINQTDIPNME DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYNWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQEIN---VQAPRSFTHVSIN----------------------- ------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Gallus_gallus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------MGN----ASRPFRRIAYFLCLLSVLLLT---EGKKPVKPK------------------------- --------------CPAWCT-CTKDNALCENARS--IPRSVPPDVISLSFVRSAFTKIPEGSFLLTPSLQLLLFTSNTFD VISDDAFMG---------------------------LPHLEYLFIENNSIKSISRNTFRGLKSLIHLSLANNNLQSLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNAFNCDCKLKWLVEWLGST-------NATVEDIYCESP PEYKKRKINSLSSKEFDCIIT---------------------------------------------------EFEVFQSL PYQSLS-VDTFSYM--NDEHVVIAQ------------PFTGK-CIFLEWD-----HVEVMFRN-YDNITGT--------- ----------STVVCKPIVIESQLYVIVAQLFGGSHIYKRDIFAN---------------KFIKIQDIEILKIRKPNDIE TFRIAE------------------DWYFVVADSS----KAGFTTVYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEFLEIA-------------GKPHLILSSSSQRPVIYQWNKG------TNEFVKRFDIQDME DAYAV-KHFKVKEDVYICLTR---FIGDSKVMKW--GGSAFLDLQRMPSRGS----MVFQPLQIRNYQYAILGSDYSFTQ VYYWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---IQAPRSFIHVSID----------------------- ------KRDFLFASSFKGTTLIYKHVRVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Taeniopygia_guttata_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------LERERIKRMGN----ASKPFRRIAYFLCLLSVLLLT---EGKKPVKPK------------------------- --------------CPAWCT-CTKDNALCENARS--IPRSVPPDVISLSFVRSAFTKIPEGSFLLTPSLQLLLFTSNTFD VISDDAFMG---------------------------LPHLEYLFIENNNIKSISRNTFRGLKSLIHLSLANNNLQSLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNAFNCDCKLKWLVEWLGST-------NATVEDIYCESP PEYKKRKINSLSPKEFDCIIT---------------------------------------------------EFEVYQSL PYQSLS-VDTFSYM--NDEHVVIAQ------------PFTGK-CIFLEWD-----HVEVMFRN-YDNITGT--------- ----------STVVCKPIVIESQLYVIVAQLFGGSHIYKRDIFAN---------------KFIKIQDIEILKIRKPNDIE TFRIAE------------------DWYFVVADSS----KAGFTTVYKWNGN----------------------------- --GFYSHQSLHAWYRDTDVEYLEIS-------------GKPHLILSSSSQRPVIYQWNKG------TNEFVKRFDIQDME DAYAV-KHFKVKEDVYICLTR---FIGDSKVMKW--GGSAFLDLQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ VYYWDAEKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---VQAPRSFIHVSID----------------------- ------KRDFLFASSFKGTTLIYKHVIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Anolis_carolinensis_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------MGS----ASRALQRGG-LLCLLGVLLLLS--EGSRSGKTT------------------------- --------------CPAWCT-CTKDNALCENARF--IPRSVPPDVTSLSFVRSAFTKIPERSFVFSPSLQLLLFTANNFD VISGDAFLG---------------------------LPHLEYLFIENNNIKSLSNTSFRGLKSLIHLSLANNNLQTLPKD IFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNAFKCDCKLKWLVAWVSRT-------NATIEDIYCESP PEYKKRKINAISPTEFDCIIT---------------------------------------------------EFVVFRKL PYQSLS-VESFSYL--NDEYVVIAQ------------PFIGK-CIFLQWD-----HVEGTFRN-FDNITGI--------- ----------SVVVCKPVIVDNRLYIIVAQLFGGSHIYKRDIHAN---------------KFIKIQDIEILKIRKPNDIE TFSIAE------------------DTYFAIADSS----KAGITTVYKWNGN----------------------------- --GFYSDQSLHEWYRDTDVEYFEIS-------------GKPHLILSSSSQHPVIYQWSKG------TSNFIDPVDIPDME DVYAV-KHFKVKEDIYVCLTR---FIGDSKVMKW--GGSKFLDLQRMPSRGS----MVFQPLQIKNYQYAILGSDYSFTQ VYFWDVGKAK---------------------------------------------------------------------- ---------------------------------FVKFQELN---IQAPRSFTHVFVD----------------------- ------KKDFLFASSFKGNTMIYKHIIVDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Xenopus_tropicalis_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------KIQRMGN----GSGSSAWISFFISFSFVLLLINWSEGKRPAKSK------------------------- --------------CPIWCT-CTKDNALCENAKS--IPRTFLPDVISLSFVRSEFTEIPEGSFLHIPSLQLLLFTSNAFD AISDDAFTG---------------------------LPHLEYLFIENNKIKSISRNAFRGLKSLIHLSLANNNLQSLPKD VFKGLDSLTNV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNAFHCDCKLKWLVEWLDKT-------NATVEQIHCESP PEYKGRKINSLSAKDFDCITT---------------------------------------------------EFAAYKSL PYQSLS-VDTFTYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEMSFRN-YDNITGT--------- ----------STVVCKPIVIEKQLYVIVAQLFGGSHIYKRDIFAN---------------KFIKIQDIEILKIRKPNDIE TFRIDE------------------NWYFVVADSS----KAGFTTIYKWNGN----------------------------- --GFYSHQSVHAWYRDTDVEFLEMTN-------------KPHLILSSSSQRPIIYQWNKK------SNEFAKHTEIPDTE DVYAV-KHFTVKDDVYLCLTR---FIGDSRVIKWE-GGSDFREIQRMPSRGS----MVFQPIEINNHKYAILGSDYSFTQ VYHWDSEKGM---------------------------------------------------------------------- ---------------------------------FVKFQELN---IQAPRSFTHVSID----------------------- ------KRDFLFASSFKGTTQIYEHVIIDLSA------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Danio_rerio_LGI1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------MGYANRSIRAYTF-LLWVAAVLLFA--ESRRGKQPR------------------------- --------------CPSGCT-CTKDNALCENVRS--VPHSFPPDVISLSFVKSGFSEIAGGSFLHTPSLQLLLFTANSFD LIDEDAFQG---------------------------LPHLEYLFIENNKIESISPHAFRGLKSLIHLSLAYNNLETLPRD IFKGMDALTKV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNLFSCDCKLKWLVEWMFST-------NATVDQLYCSGP SPYQGKKINDLMPQSFDCITA---------------------------------------------------EFALKKTL AFESIS-VEAFSYG--NDQYVVYAQ------------PFTGR-CNFMEWD-----HVNMEFRD-HEIILST--------- ----------STVVCKPMVIDDHLFIVVAQLFGGSHIYKRDSSAN---------------KFIKIQDIDILKIRKPNDIE TFRVDG------------------EFYFVIADSS----KAGSTTVYKWNGN----------------------------- --GFYSHQSLHPWYRDTDVEYLEIA-------------GKPHIILSSSSQRPVVYQWSRS------QKQFDRRTDIPDME DVYAV-KHFKVKGELFICLTR---FIGDSKVMKW--DGAMFIEIQTMPSRGS----MVFQPVSIGNWQYAILGSDYSLTQ VYQWDAKKSQ---------------------------------------------------------------------- ---------------------------------FVHFQELN---VQAPRAFSLASID----------------------- ------NREFLLASSFKGKTQIYEHLMIDLSS------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Danio_rerio_LGI1b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MMCLRRAAVLCVLLAALVLG-----GRRRSSR------------------------- --------------CPAPCT-CSKDNALCANTGA--IPRSFPQDVISLSFVKSGFTEIPKESFIHTPALHLLLFTANSFD SINEDAFLG---------------------------LPHLEYLFIENNQIKSISPFAFRGLKSLIHLSLAYNNLETLPKD LFKGMEALTKV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNLFSCDCKLKWLVDWMFHT-------NATVDQIFCNGP EGYQGKKINDLEAQTFDCITT---------------------------------------------------DFTLLKSL EFQSIS-VEAFSFA--GDQFVVFAQ------------PFSGR-CSFMEWD-----HVQMEFRN-FDNITST--------- ----------STVICKPLVIDSQLFIIVAQLFGGSHIFKRDVSAN---------------KFIRIQDIDILKIRKPNDVE IFEVDG------------------ESFFIIADSS----KAGSTTIYKWNGN----------------------------- --GFYSYQSLHPWHRDTDVEYLDIS-------------GKPHLILSSSSQRPVVYQWSRG------SAQFERRTDIPEME DVFAV-KHFTVKNELYICLTR---FIGDSKVMRW--DGSMFTEIQTVASRGS----MVFQPFSVASWQYAILGSDYAFTR VYRWDAKKRQ---------------------------------------------------------------------- ---------------------------------FVPFQELN---IQAPRAFSLVFID----------------------- ------NREFLLGSSFKGQTRIYEHLVLDLSS------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Takifugu_rubripes_LGI1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------EGMGLSDRGWRGRTLPFLVIAVSVISA--DGLRVRQPR------------------------- --------------CPFGCT-CTKDNALCENVRS--VPHTFPPDVVSLSFVKTGFSGITGGSFVHTPVLQLLLFTGNSFD FIDEDAFMG---------------------------LPHLEYLFIENNKIASISPNAFRGLKGLLHLSLAYNNLETLPRD VFSGMEALTKV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNNLICDCKLKWLVEWMHHT-------NATLDEIYCSGP PSYQGKRLNDLLPHSFDCITS---------------------------------------------------EFASYQSL KFESIS-VEAFTFG--MDQYVVFAQ------------PFAGT-CNFLEWD-----HVEMTFRT-YDTIEST--------- ----------STVVCKPMVIDNHLFVIVAQLFGGSHIYKRDVSAN---------------KFIKIQDIDILKIRKPNDIE TFMIEG------------------ESYFVIADSS----KAGSTTVYKWNGN----------------------------- --GFYSHQSLHHWYRDTDVEYLVIS-------------NKAHLILSSSSQRPVIYQWNRS------QKQFERRTDIPDME DVFSV-KHFHVKGELFICLTR---FIGDSKVMRW--DGAMFKELQTFPSRGS----MVFQPVSIGKWQYAILGSDYSLTQ VYQWDAKKGQ---------------------------------------------------------------------- ---------------------------------FVPSQELN---IQAPRSFSVLFVD----------------------- ------SRVFLLASSFKGKTQIYEHLIIDLSNSTF--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Takifugu_rubripes_LGI1b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------VQDFCLASMENSPKMPMRSTWLFSLVVASVFLAV--VVGKPKQPR------------------------- --------------CPTHCT-CTKDNALCQSADI--IPRSFPREVTSLSFANSKFTEIPKESFIHSPGLHLLLFTANNLE SINEDSFLG---------------------------LPHLEYLFIENSQIQTISPNAFNGLKTLVHLSLAFNNLETLPKD LFRGLEALTKV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNQFACDCKLKWLVEWIYST-------NATVDQIYCKGP ASQLDKKINSLLPQSFDCITT---------------------------------------------------EFASYQSL DFKTLS-VEAFSFG--NDQYVVFAQ------------PFNGK-CTFLEWD-----HVEMVFRK-YDEINST--------- ----------STVICKPLVIDDQLFVIVAQLFGGSHIYKRDSSAN---------------KFIKLQGIDILKIRKPNDVE TFRIDG------------------ESFFIIADSS----KAGSTTIYKWNGN----------------------------- --GFYSHQSLHPWYRDTDVEYMEIS-------------SKPHLILSSSSQRPVIYQWNKG------TKQFERRTDIPEME DVYAV-KHFHVKSDLFICLTR---FIGDSKVMRW--DGALFRELQTMPSRGS----MVFQPFTLGSWQYAILGSDYSFTQ VYRWDAKKGE---------------------------------------------------------------------- ---------------------------------FVQFQEVN---IQAPRAFSPVSID----------------------- ------NRQFLLASSFKGKTQIYGHLVIDLSN------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Tetraodon_nigroviridis_LGI1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------MGLPGRGWRGRTL-VLVVAVSVISA--DGWRVRQPR------------------------- --------------CPYGCT-CTKDNALCENVRS--VPHTFPPDVVSLSFVKTGFSGITGGSFVHTPVLQLLLFTGNSFE FIDEDAFMG---------------------------LPHLEYLFIENNKIASISPYAFRGLKGLLHLSLAYNNLETLPRD VFSGMEALTKV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNNLICDCKLKWLVEWMHQT-------NATLDEIYCSAP PVYQGKRLNDLLPHSFDCITA---------------------------------------------------EFASYQSL KFESIS-VEAFTFG--MDQYVVFAQ------------PFAGT-CNFLEWD-----HVEMTFRT-YDTIEST--------- ----------STVVCKPMVIDNHLFVIVAQLFGGSHIYKRDVSAN---------------KFIKIQDIDILKIRKPNDIE TFTIEG------------------ESYFVIADSS----KAGSTTVYKWNGN----------------------------- --GFYSHQSLHHWYRDTDVEYLVIS-------------NKAHLILSSSSQRPVVYQWNRS------QKQFERRTDIPDME DVFSV-KHFHVKGELFICLTR---FIGDSKVMRW--DGAMFRELQTFPSRGS----MVFQPISIGKWQYAILGSDYSLTQ VYQWDAKKGQ---------------------------------------------------------------------- ---------------------------------FVPSQELN---IQAPREFSVLSVD----------------------- ------NRVFLLASSFKGKTQIYEHLIIDLSNSTF--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Tetraodon_nigroviridis_LGI1b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------LQDFCLAGLGNLPKMPTRSPRLFLLVLASVLLAV--VIGKPKQPR------------------------- --------------CPTHCI-CTKDNALCQSADI--IPRSFPREVTSLSFANSKFTEIPKESFIHSPGLHLLLFTANNLE SINEDSFLG---------------------------LPHLEYLFIENSQIQSISPNAFNGLKTLVHLSLAFNNLETLPKD LFKGLEALTKV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNQFICDCKLKWLVEWIDST-------NATVDQIYCKGP ASQLDKKINSLVPQAFDCITT---------------------------------------------------EFASYQSL DFKTLS-VEAFSFG--SDQYVVFAQ------------PFNGK-CTFLEWD-----HVEMVFRK-YDEINST--------- ----------STVICKPLVIDNQLFIIVAQLFGGSHIYKRDSSAN---------------KFIKLQGIDILKIRKPNDVE TFRIDG------------------ESFFIIADSS----KAGSTTIYKWNGN----------------------------- --GFYSHQSLHPWYRDTDVEYLEIS-------------SKPHLILSSSSQRPVIYQWNKG------AKQFERRTDIPEME DVYAV-KHFHVKSDLFICLTR---FIGDSKVMRW--DGALFRELQTMPSRGS----MVFQPFILGSWQYAILGSDYSFTQ VYRWDAKKGQ---------------------------------------------------------------------- ---------------------------------FVQFQEVN---IQAPRAFSPVSID----------------------- ------NRQFLLASSFKGKTQIYEHLVIDLST------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Gasterosteus_aculeatus_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------KTQRES----DALLLGLLLMLMARNVLLAV--DSKRVRPPR------------------------- --------------CPSSCT-CTKDNALCESAGL--IPRSFPPDVISLSFVKSEFTEIPKESFIHTPALHLLLFTANNLE SINEDAFLG---------------------------LPHLEYLFIENNQITSISPYAFRGLKTLVHLSLAYNNLETLPKD LFKGLEALTKV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNQFTCDCKLKWLVEWMYST-------NATVDQIYCKGP AAQLDKKINDLVPLSFDCITT---------------------------------------------------EFASYQSL KFESIS-VEAFSFG--NEQYVVFAQ------------PFIGK-CSFLEWD-----HVEMVFRS-FDDIDST--------- ----------STVICKPLVIDNQLFVIVAQLFGGSHIYKRDSSAN---------------KFIKLQGIDILKIRKPNDVE TFRIDG------------------ESFFVIADSS----KAGSTTIYKWNGN----------------------------- --GFYSHQSLHPWYRDTDVEYMEIS-------------SKPHLILSSSSQRPVIYQWNKT------TKLFDRRTDIPEME DVYAV-KHFQVKSDLFICLTR---FIGDSKVMRW--DGALFRELQTMPSRGS----MVFQPFSVGSWQYAVLGSDYSFTQ VYRWDAKKGE---------------------------------------------------------------------- ---------------------------------FVHFQEVN---IQAPRAFSPISID----------------------- ------NRQFLLASSFKGKTQIYEHLVIDLSD------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Oryzias_latipes_LGI1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------LCPQRFARMGITAKRSQWLGVLAAASLLLLV--GSKRARQPR------------------------- --------------CPLSCT-CTKDNALCEGAGS--IPRSFPPDVMSLSFVKSEFTEIPKESFIHTPGLHLLLFTANILE SINEDAFIS---------------------------LPHLEYLFIENNQINSISPHAFRGLKTLVHLSLAYNNLETLPRD LFRGLDALTKV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNHFTCDCKLKWLVEWIFST-------NATVDQVYCKGP ASHLDKSINDLEPQSFDCITT---------------------------------------------------ELASHQSL KFESIS-VEAFFFE--NNQYVVFAQ------------PFIGK-CSFLEWD-----HVEMLFRTRYDDIDST--------- ----------STVICKPLVIDNQLFVIVAQLFGGSHIYKRDSSAN---------------KFIKLQGIDILRIRKPNDIE TFSIDG------------------ESFFVIADSS----KAGTTTIYKWNGN----------------------------- --GFYSHQSLHPWYRDTDVEYLEIS-------------SKPHLILSSSSQRPVIYQWNRT------TKLFERRTDIPEME DVYAV-KHFQVDSDLFICLTR---FIGDSKVMRW--DGALFREAQTMPSRGS----MVFQPFAVGSWQYAILGNDYSFTQ VYRWDAKKGE---------------------------------------------------------------------- ---------------------------------FVRFQELN---IQAPRAFSPVAID----------------------- ------NRQFLVASSFKGKTQIFEHRIIDLSN------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Oryzias_latipes_LGI1b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------SLAYNNLDTLPRD VFKGMDALNKV--------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------DLRGNNLICDCKLKWLVEWMHQT-------NATLDQIHCSGP PNYQGRKINDLLPHSFDCITT---------------------------------------------------EFASYQPL KFESIS-VEAFTFV--NEQYVVFAQ------------PFAGT-CSFLEWD-----HVEMTFRT-YDTIEST--------- ----------STVVCKPMVIDHHLFVIVAQLFGGSHIYKRDSSAN---------------KFIKIQDIDILKIRKPNDIE TFMING------------------ESFFVIADSS----KAGSTTVYKWNGN----------------------------- --GFYTHQSLHPWYRDTDVEYLEIS-------------NKPHLILSSSSQRPVVYQWNRS------QKKFDRRTDIPDME DVFSV-KHFWVKGDLFICLTR---FIGDSRVMRW--DGAMFREVQTFPSRGS----MVFQPVSVSNWQYAILGSDYSLTQ VYQWDTKRGQ---------------------------------------------------------------------- ---------------------------------FIPSQELN---IQAPRSFSVVSVD----------------------- ------DRVFLLASSFKGKSQIFEHHEIDLSD------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Ciona_intestinalis_LGI1 -------------------------------------------------------------------------------- ------------------------------------------------------------------------------LS LLCFMILFSTSYSSSTPSTIVSCPSPCTCSYKERLVNCSNRSLRKIPLIPPWVSILSLRNNKIEATAVKQHTFMNLPNLL ELDLSDNELRTLSVSFSGSPLLRTLTLKQTKLKHVWLGMVSASGLCKAYSEIQMNWG----------------------- -------LIAIFLIRINVTYITNIPYHRSHNIITTIDGLTEWPSLRVLDLSFNTIRGIRSNTFINQRNLTELYLHKNNIT TVNEHAFAG--------------------------LVSLETLSDLSRNRINHIKGLAFNGMCQLRTLLLHGNRISNLKDA SFYSLKALTTLRMDDN---------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------RIRSVDMGWLYDLKSLEKLSLSRNKVNSISSGAWKLCKEIRH LNLSHNDLTTIISKQFESLTVMQT---------------------------------------------LDLSRNAIVAM EKEAFYGLRKLKKLVLSRNLISSSVEDLG----GIFRGLDSIETLLMNNN-----RIRSLSPDTFVGADKLVYLDLRNNN ITSVQNKTFQTMKNLKRLRINSAAFLCDCQLAWFSQWLRDSNINTRS------------EGNCRCFHPPKLKGRRVVNIG SNEFECG---------------EHPIPTLLQQPSKLTAYKGENVTLECSASATL-----------------------TKN VSNVKSSALMSVVWRRGRSKTLSHESQ-------KIRIRKPQRIEGGHIFFTSFLILYDVTYDSDDDYSCVISNEFGHAK STPAAHLSVYVYPTITKQPEDRTVKSGSEVIFQCQASGHPIPDISWQKDGGS------SFPAAHERRLVRTQNAPLHISE VQPKDAGVYTCTAKSVAG-------------------------------------------------------------- ----------------------VQSVSATLTVLYPPIVEKMPDKIEAVKGGNAVLKCMSSAN------------------ ---PAPQVTWLLNGGVLNGTTRHFFAAGDQLLVIVNFSSLDQGEYACSV------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------- >Ciona_savignyi_LGI1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------NRIQIIPSFSFSSYPQLRRIDLSNNEIK EIERDAFDG---------------------------LSQLSSLVMYGNKITSLPAGIFTHMHNLQMLLMNANKIKCLRQD VFSGLRSLTLLSLYDNKLQSISRGTFANLRSIET---------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------INLLSNPLDCNCHLSWLSTWLRRS-------PVSSGNPRCAEP RFLREFPVADINPRDFRCSTEQEARAAPTCLP-VQKCPEQCTCEGTIVRCANTGLTSVPVDDIPHDVTELYLEMNDIREI P-ASIKKFIYLTTLDLSNNDISSIN-------DWMFSNLTRLSTLLLAYN--