>Homo_sapiens_KLF1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------MATAETALPSISTLTAL------GPFPDTQDDFLKWWRSEEAQDMGPGPPDPTEPPLHVKS E-------------------------------------------------------------DQPGEEEDDERGA---DA TWDLDLLLTNFSGPEP------------GGAPQTCA----------LAPSEASGAQYPPP-------------------- ----------------------------------------PETLGAYAGGPGLVAGLLGSEDHS-----GWVRPALRARA PDAFVG-------------PALAPAPA----------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------PEPKALALQPVYPGPGAGSSGGYFPR--------------------- ---------TGLSVPAASG------------APYGLLSG----------------------------------------- -----------------------------------------------------YPAMYPAPQYQGHFQLFRGLQGPAPGP ATSP------------------------------------------------------------------SFLSCLGPGT VGTGLGGT----------------------------------------AEDPGVIAETAP-------------------- -----------SKRGRRSWARKRQAAHTCAHPGCGKSYTKSSHLKAHLRTHT---GEKPYACTWEGCGW-RFARSDELTR HYRKHTGQRPFRCQLCPRAFSRSD----------HLALHMKRHL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Mus_musculus_KLF1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -MRQKRERRPEVQGGHQPAMASAETVLPSISTLTTL------GQFLDTQEDFLKWWRSEETQDLGPGPPNPTGPSHHVSL KS-----------------------------------------------------------EDPSGE--DDERDV---TC AWDPDLFLTNFPGSES------------PGTSRTCA----------LAPSVGPVAQFEPP-------------------- -----------------------------------------ESLGAYAGGPGLVTGPLGSEEHT-----SWAHPTPRPPA PEPFVA-------------PALAPG------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------LAPK---AQPSYSDSRAGSVGGFFPR--------------------- ---------AGLAVPAAPG------------APYGLLSG----------------------------------------- -----------------------------------------------------YPALYPAPQYQGHFQLFRGLAAPSAGP TAPP------------------------------------------------------------------SFLNCLGPGT VATELGATA--------------------------------------IAGDAGLSPGTAP-------------------- -----------PKRSRRTLAPKRQAAHTCGHEGCGKSYTKSSHLKAHLRTHT---GEKPYACSWDGCDW-RFARSDELTR HYRKHTGHRPFCCGLCPRAFSRSD----------HLALHMKRHL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Drosophila_melanogaster_KLF1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MVFMNGLGSDP---------------------LSAKEAEGPPVQVEPVDLSLR---- ----------------------------------------------------SPRASTSHGSSSSSYKFSSANKAVGYSN G--KPGGSSGSSSSSG---------------------------------------------------------------- -FGAGSAGSSSLGAFAAQQQQQ-----------------LYASSG---------VSKLPFSPFFAASPFFFTYRR----- ----------------ISGSGSGNGTGS--------------------------------------VSVKQE-------- -----------------------------------------------------------------------DNNNSCS-- -------------------------------YNNGSSSGGAGSAANSMQDYESKFSLLS--------------------L FKNPYKFAGGDGQASRKTS-------PTGGSSKPLASNSSPSWKSYAGS------------------------------- -GSPHAALN-------------------------------------------PAFGGMGRGATRKDNSSFSGIN------ -------------------------------------------------------------------------------- ------------------------FGGGG----------SAFGFTTSSDSMANGGYNDLS-------------------- ---------------------KNRKVHKCDTEGCDKVYTKSSHLKAHKRTHT---GEKPYVCTWEGCIW-RFARSDELTR HYRKHTGVKPFRCQLCTRSFSRS---DH-------LSLHMRRH------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Homo_sapiens_KLF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------MALSEPILPSFSTFASPC----------RERGLQERWPRAEPE------------------ -----------------------------------------------------------------SGGTDDDLNS----- VLDFILSMGLDGLGA-------------EAAPEPPP----------PPPPPAFYYPEPG--------------------- -----------------------------------------APPPYSAPAGGLVSELLRPEL---------DAPLGPALH GRFLLAPP----------GRLVKAE------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------PPEADGGGGYGCAPGLT-RGPRGLKRE----------------GAPGP AASCMR----GPGGRPPPPPDTP------PLSPDGPARLPAP-------------------------------------- -----------------------------------------------------GPRASFPPPFG-GPGFGAPGPGLHYAP PAPP------------------------------------------------------------------AFGLFDDAAA AAAALGLA--------------------------------------PPAARGLLTPPASP-------------------- ----LELLEAKPKRGRRSWPRKRTATHTCSYAGCGKTYTKSSHLKAHLRTHT---GEKPYHCNWDGCGW-KFARSDELTR HYRKHTGHRPFQCHLCDRAFSRSD----------HLALHMKRHM------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Mus_musculus_KLF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------MALSEPILPSFATFASPC-----------ERGLQERWPRNEPE------------------ -----------------------------------------------------------------AGGTDEDLNN----- VLDFILSMGLDGLGA-------------ENPPEPPP----------QPPPPAFYYPEPG--------------------- -----------------------------------------APPPYSIPAASLGTELLRPDL---------DPPQGPALH GRFLLAPP----------GRLVKAE------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------PPEVDGGG-YGCAPGLA-HGPRGLKLE----------------GAPGA TGACMR----GPAGRPPPPPDTP------PLSPDGPLRIPAS-------------------------------------- -----------------------------------------------------GPRNPFPPPFGPGPSFGGPGPALHYGP PAPG------------------------------------------------------------------AFGLFEDAAA AAAALGLA--------------------------------------PPATRGLLTPPSSP-------------------- ----LELLEAKPKRGRRSWPRKRAATHTCSYTNCGKTYTKSSHLKAHLRTHT---GEKPYHCNWEGCGW-KFARSDELTR HYRKHTGHRPFQCHLCDRAFSRSD----------HLALHMKRHM------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Tetraodon_nigroviridis_KLF2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------MALSGVMLPSFSTFSNQ-----------REKTWETGWKADMDKLVSAGCSVVELGQNQDN- ----------------------------------------------------------------HGK-DDEDLSD----- YLDLDFILANTAGS--------------DSAAEYVG----------TVDQG--MYAPGN--------------------- -------------------------------AVPSYAADSHHRSPPPPYGASLMTELLRGES-----TNNYGITRHNGVQ GRFYVNSV----------HFPRQEG------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------IKVEP-PMDGYGPVLGMVPQSCGKIKQE----------------GNVSC MMSFEQ-PRVAISPR-AASNMTP------PLSPDDQGASDCQ-------------------------------------- -------------------------------------------------ANLCQPMN-FTQKYHPPAAFSHHPQAPQMQM PY---------------------------------------------------------------HAPHPAFGMY--DEG LSLQP------------------------------------------GAQRVMLTPPSSP-------------------- ----LELLESKPKRGRRTWPRKRTATHVCSFAGCGKTYTKSSHLKAHLRTHT---GEKPYHCSWEGCGW-KFARSDELTR HYRKHTGHRPFQCHLCERAFSRSD----------HLALHMKRHI------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Ciona_intestinalis_KLF2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------MIKIDMGNSDELPGFPQIGMPSGR-E GILSQASTGDVLLTDLENLWEENPDCLESILNTSNSECGSD--IVGLGGVGSTEKLASIGETFSRQNQGCEIADNGYYCS -------------------------------------------------------------GFTTCNSLTEPATSGLGSE FFTNYSNSTDSGMKREQ--------------------------------------------------------------- -------------------------------------HTSPFMYERLGSTSQEIESYQNFEQKCRSFETLHEKLHSSAAY KSTQTINNGQWHPATEFYHQQLEHSISLPNGLVTP--------------------------------------------- -------------------------------------------------------------------------------- --------------------------------PVSPEEERRRSTPPQHTHSSFTPLPEHCIKT---EHPNIYNGCERLCE TNYQTSCAQYTTGAYNSLNSTTTGIGGVGVQQHLPKYPKPMYSEDIQTLQ------------------------------ -----------------------------------------------QTNKPPFAHTARSNSWPHQQPNGNCELVFNP-- -------------------------------------------------------------HSATMFTHPSFK------- -------------------------------------PEDAAFSILPHYPVKQAVVDDNTAVEKTK-------------- -------------RGRRYWTRRKATLHTCEYIGCGKTYTKSSHLKAHMRTHT---GEKPYHCTWAGCGW-RFARSDELTR HYRKHTGHRPFKCNMCERAFSRSD----------HLALHMKRHM------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Homo_sapiens_KLF3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MLMFDPVPVKQ----------------------EAMDPVSVSYPSNYMESMKP---- -------------------------------------------------------NKYGVIYSTP--LPEKF-FQTPEGL SHGIQMEPVDLTVNKR---------------------------------------------------------------- --SSPPSAGNSPSSLKFPSSH------------------RRASPGLSMPSSSP--PIKKYSPPSP-GVQPFGVPL----- ---------------SMPPVMAAALSRH---------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------GIRSPGILPVIQPVVVQPVPFMYTS--------------------- -HLQQPLMVS--LSEEMEN-------SSSSMQVPVIESYEKP-ISQ---------------------------------- ---KKIKIEPG-------------------------------------------IEPQRTDYYPEEMSPPLM-------- -------------------------------------------------------------NSVSPPQA----------- LLQENHPSVIV-----------------------------------QPG-KRPLPVESPDTQ------------------ ---------------------RKRRIHRCDYDGCNKVYTKSSHLKAHRRTHT---GEKPYKCTWEGCTW-KFARSDELTR HFRKHTGIKPFQCPDCDRSFSRS---DH-------LALHRKRHMLV---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Mus_musculus_KLF3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MLMFDPVPVKQ----------------------EAMDPVSVSFPSNYIESMKP---- -------------------------------------------------------NKYGVIYSTP--LPDKF-FQTPEGL THGIQVEPVDLTVNKR---------------------------------------------------------------- --GSPPAAGGSPSSLKFP-SH------------------RRASPGLSMPSSSP--PIKKYSPPSP-GVQPFGVPL----- ---------------SMPPVMAAALSRH---------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------GIRSPGILPVIQPVVVQPVPFMYTS--------------------- -HLQQPLMVS--LSEEMDN-------SNSGMPVPVIESYEKP-LLQ---------------------------------- ---KKIKIEPG-------------------------------------------IEPQRTDYYPEEMSPPLM-------- -------------------------------------------------------------NPVSPPQA----------- LLQENHPSVIV-----------------------------------QPG-KRPLPVESPDTQ------------------ ---------------------RKRRIHRCDYDGCNKVYTKSSHLKAHRRTHT---GEKPYKCTWEGCTW-KFARSDELTR HFRKHTGIKPFQCPDCDRSFSRS---DH-------LALHRKRHMLV---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Xenopus_tropicalis_KLF3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MLMFDPVPIKQ----------------------EAMEPIPMPYQHSFMEPLKT---- -------------------------------------------------------NKYSVIYPTSNLLHSKFPYHMPEGL P-GLQMEPVDLTTNKR---------------------------------------------------------------- --NSPPSTGSSPSPIKYQSPK------------------RRSPPVLYMPSSSP--PIKKLSPSPP-ALPPFTMPL----- ---------------AINP-MISAFPRH---------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------GYRNPGLLPLLQPVVVQPVPFMYSP--------------------- -HLQQPIMVSTLLPEELEN-------PHNKHVVAVTEPYEKPPPLM---------------------------------- ---KTIKIEPG-------------------------------------------LEQQNPEFYPEQLSPG---------- --------------------------------------------------------------ISTPPKG----------- MNYENHPSVIV-----------------------------------HPG-KRPLPVESPETQ------------------ ---------------------RKRRIHRCDYEGCNKVYTKSSHLKAHRRTHT---GEKPYQCTWEGCTW-KFARSDELTR HFRKHTGIKPFQCPDCDRSFSRS---DH-------LALHRKRHMLV---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Tetraodon_nigroviridis_KLF3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------SSGVMVSPVMVPLSVLYSSS-------------------- LHLHQPIMVSPSLSSDDD--------HHRSREHRKVHATKTFDLQG---------------------------------- ---DPHDLHKS-------------------------------------------IKTEARPECSGDINGGHK-------- -------------------------------------------------------------AKT---------------- ---GNNPSVIV-----------------------------------HSGTQHPVPAESPDTL------------------ ---------------------KKRRIHRCDFSGCNKVYTKSSHLKAHRRTHT---GEKPYKCMWEGCTW-KFARSDELTR HFRKHTGVKPFQCPASAAS-SRS---DH-------LALHKKRHLLV---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Homo_sapiens_KLF4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MRQPP-GESDMAVSDALLPSFSTFASG--PAGREKTLRQAGAPNNRWREELSHMKRLPPVLPGRPYDLAAA TVATDLESGGAG------------------------------------------AACGGSNLAPLPRRETEEFND----- LLDLDFILSNSLTHPP--------ESVAATVS-SSA----------SASSSSSPSSSGPASAP----------STCSFTY PIRAGNDPGVAPGGTGGG------LLYGRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLM GKFVLKASLSAPGSEYGSPSVISVSKG----------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------SPDGSHPVVVAPYNGGPPRTCPKIKQE----------------AVSSC T-------HLGAGPPLSNGHRP---------AAHDFPLG-RQL------------------------------------- -------------------------------------------------PSRTTPTLGLEEVLSSRDCHP--------AL PLPPG----------------------------------------------------------FHPHPGPNYP-SFLPDQ MQPQVPP----------------------------------------LHYQELMPPGSCM-------------------- ----PE--EPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHT---GEKPYHCDWDGCGW-KFARSDELTR HYRKHTGHRPFQCQKCDRAFSRSD----------HLALHMKRHF------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Mus_musculus_KLF4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------MRQPP-GESDMAVSDALLPSFSTFASG--PAGREKTLRPAGAPTNRWREELSHMKRLPP-LPGRPYDLAAT -VATDLESGGAG------------------------------------------AACSSNNPALLARRETEEFND----- LLDLDFILSNSLTHQ---------ESVAATVT-TSA----------SASSSSSPASSGPASAP----------STCSFSY PIRAGGDPGVAASNTGGG------LLYSRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLM GKFVLKASLTTPGSEYSSPSVISVSKG----------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------SPDGSHPVVVAPYSGGPPRMCPKIKQE----------------AVPSC TVSRSLEAHLSAGPQLSNGHRP---------NTHDFPLG-RQL------------------------------------- -------------------------------------------------PTRTTPTLSPEELLNSRDCHP--------GL PLPPG----------------------------------------------------------FHPHPGPNYP-PFLPDQ MQSQVPS----------------------------------------LHYQELMPPGSCL-------------------- ----PE--EPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHT---GEKPYHCDWDGCGW-KFARSDELTR HYRKHTGHRPFQCQKCDRAFSRSD----------HLALHMKRHF------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Xenopus_tropicalis_KLF4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------MKRHSVPNQSRAYDGLEMD---------------- ------------------------------------------------------------SPALVTRREPEEFNE----- LLDFDFILSNSLIHQE--------SMTVGSSSSSSS----------VTASSPPPPATLPDTMSALSS------TTCNFVY QVRCPQE-------SSGG-----TLMYNARDPTMSSATFNLADINDVSPSGGFVAELMRPDLDPVFMQQ----QPQASLQ GKFVLKTTVS--MGDYG--QTISVRKN----------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------NSGIDSPLSYTTHQLPRVCQKIKQE----------------PSSSC T---------SACPMDGQGQQS--------QSMREFQAG-RGL------------------------------------- -------------------------------------------------PIRTNQSLSPEELMG-RDCHSSSQTLSHSSL PIPPA----------------------------------------------------------YHT--SASFS-HFTSDQ PQTQLPPT--------------------------------------QLQYQELLTTGGCI-------------------- ----PE--ESKPKRGRKSWPRKRTATHTCEYAGCGKTYTKSSHLKAHLRTHT---GEKPYHCDWEGCGW-KFARSDELTR HYRKHTGHRPFQCQRCDRAFSRSD----------HLALHMKRHF------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Tetraodon_nigroviridis_KLF4_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------SRQPPNDVEMALGGTLLPSISTFASG-----PAIKTKSIGSANLRWKEELSLLKKPGVPTESSSGGSDPD R------------------------------------------------------PTATSTTSLGMSKKHPEPDL----- DLDYDFILSNSMK-------------EPMACSSAQA----------LSPSPGPFASTYPLPSP----------------- ------------------------------QGGTGELLYTLPDISDVSPSGGFVAELMRPELDP-------AYLHPTSLH GKFVVKTTMDVG------EYSQGVSVG----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------AASD------SPSFTCHRIKQE----------------SPSNC TLG-PGDLHLAGGSSQGRG---------SHLDHRGFPAR-RASAGG---------------------------------- -------------------------------------------------RKVTLFFLPLPGPPAEPGASGPGPPPLSAQP TSAG-----------------------------------------------------------IPPELPAGYSPYPQLPS VPYQE---------------------------------------------PLVISGGDPL-------------------- ----AE--EPKPKRGRRSWPRKRVATHTCDYVGCGKTYTKSSHLKAHHRTHT---GEKPYHCDWEGCGW-KFARSDELTR HYRKHTGHRP-QCQKCDRAFSRSD----------HLALHMKRHL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Homo_sapiens_KLF5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MATRVLSMSARLGPVP---QPPAPQDEPVFAQLKPVLG-AANPARDAALFPGEELKHAHHRPQ---- --------------AQPAPAQAPQPAQPPATGPRLPPEDLVQT-----------RCEMEKYLTPQLPP-VPIIPEH---- ---------------------------------------------------------------KKYRRDSASVVDQFFTD T--E-GLPYSINMNVF---------------------------------------------------------------- -LPDIT----HLRTGLYKSQR------PCVTHIKTEPVA-IFSHQSETTAPPPA--PTQALPEFTSIFSSHQTAAP---- -----------------EVNNIFIKQELPTPDLHL--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SVP-TQQGHLYQLLNTP------DLDMP---------------SSTNQT AAMDTLN-VSMSAAMAGLNT--HTSAVPQTAVKQFQGMPPCTYTMPSQF------------------------------- -----LPQQ------------------------------------------ATYFPPSPPSSEPGSPDRQAEMLQNLT-- ------------------------------------------------------------PPPSYAATIAS--------- KLAIHNPN---LPTTLP-------------------------VNSQNIQPVRYNRRSNPDLE------------------ ----------------------KRRIHYCDYPGCTKVYTKSSHLKAHLRTHT---GEKPYKCTWEGCDW-RFARSDELTR HYRKHTGAKPFQCGVCNRSFSRS---DH-------LALHMKRHQN----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Mus_musculus_KLF5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MPTRVLTMSARLGPLP---QPPAAQDEPVFAQLKPVLG-AANPARDAALFSGDDLKHAHHHP----- ------------------------PAPPPAAGPRLPSEELVQT-----------RCEMEKYLTPQLPP-VPIISEH---- ---------------------------------------------------------------KKYRRDSASVVDQFFTD T--E-GIPYSINMNVF---------------------------------------------------------------- -LPDIT----HLRTGLYKSQR------PCVTQIKTEPVT-IFSHQSESTAPPPPPAPTQALPEFTSIFSSHQTTAPPQ-- -----------------EVNNIFIKQELPIPDLHL--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------SVP-SQQGHLYQLLNTP------DLDMP---------------SSTNQT AVMDTLN-VSM----AGLNP--HPSAVPQTSMKQFQGMPPCTYTMPSQF------------------------------- -----LPQQ------------------------------------------ATYFPPSPPSSEPGSPDRQAEMLQNLT-- ------------------------------------------------------------PPPSYAATIAS--------- KLAIHNPN---LPATLP-------------------------VNSPTLPPVRYNRRSNPDLE------------------ ----------------------KRRIHFCDYNGCTKVYTKSSHLKAHLRTHT---GEKPYKCTWEGCDW-RFARSDELTR HYRKHTGAKPFQCMVCQRSFSRS---DH-------LALHMKRHQN----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Tetraodon_nigroviridis_KLF5_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------SSSSALMAASVGAAA--NPP-HADERAVFTQLKPVRMS--DGAEDASVFEDVKPPVSPGASA---- ---------------GKQVSGSPGPGEPLT----WPS--FFQV-----------QLDLDKYLPRVGSPLLSLPADGAD-- ---------------------------------------------------------------RKYRRESASVVDEYFSE EK-P-TAPYSLNINLI---------------------------------------------------------------- -LPSTA----HLRTGLYRPN-----KPLPPQQIKTEP-------DLEVPCSVPGPASTQALPDFTSVFNVHP-------- -----------------VASNVFVKPDLGAEAAGVVGVPSGS-------------------------------------- -------------------------------------------------------------------------------- ---------------------------QELQIGPPAPQQHVYHMPIAG----GADLTMT---------------LSHSGA SAHGAAGG-AMLGLGGPA-----LPMASRAYMMAEHQLAQQQGYYQA--------------------------------- ------------------------------------------------SAAPHSLPPSPPNSQPASPDGQAELLS----- ----------------------------------------------------------------YQQRLG---------- KMAGLTPH-----ALL------------------------MTHGQGVLTGPKYNRRNNPELE------------------ ----------------------KRRIHFCDYPGCTKVYTKSSHLKAHQRTHT---GEKPYRCTWENCDW-RFARSDELTR HYRKHTGAKPFKCVACSRCFSRS---DH-------LALHMKRHQN----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Tetraodon_nigroviridis_KLF5_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------CDLDRYLSPQPLCPPPASDGQ---- ---------------------------------------------------------------LKAQRDGAALLEPFLAE EP-A-GAPYTLNMNLY---------------------------------------------------------------- -LPDGA----YLRMGLRQPP-----AHASLAPVKSEAPSPCFSPGLQETGAINM--RLTGLPDFCSVFSHAG-------- ----------------APASDVFVKQEAPPSLTCT--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------PTAGAPSS-----------------SCP---------------PPAWDH HHGNGMEAQQMHAPSSTVPAPFHNLPGASSGSQ----------------------------------------------- -----------------------------------------------------------PSSEPGSPDRQKELLHAMS-- ------------------------------------------------------------PPPSYAASIAS--------- KLAG-PNSQ--TPAAPP----------------------------PTSTPARYNRRNNPDLE------------------ ----------------------KRRIHHCDYPGCRKVYTKSSHLKAHLRTHT---GEKPYRCTWDSCDW-RFARSDELTR HYRKHTGAKPFQCSVCSRSFSRS---DH-------LALHMKRHQN----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Ciona_intestinalis_KLF5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------MAAAVALNYPSPNFSSEFPAENFYSARSLEQAASVSEASSFSPVSSPEFLSFEQNTISDASIDNFECAM NDFYIEQQLDNSASLKTGDVIMPPPMTSRTTYSSDPNIFRRES-----------ASDIHDILNPGIRNNCPGYQANSASN NIYQQTNNYSNIDTNNGACVNVNFNVVVKQQNNHHYHNSPTSPTHDVIPQNAMTSPAGMTSPPGSPNMLNIPPVSSFIKN SEAILHPSSSPTMTSSPVTS------------------------------------------------------------ -HTYPQMHHEEYTRARIPSESESV--VCYDQRRHASLPSITITNLDENESMMQAYQRTRSTSLTTDRCSIPSTSPNP--- -----------------GSPPVQMA-QQPCSPVNMANTKQYQ-------------------------------------- -------------------------------------------------------------------------------- ---------------------------VKTEVN--TQPLGSWDSNMMMYSEPAPSPFNAR--------------RCSSEV GAISTPTNDGFMPMNGMIAPKIEKLYPDDQYTANNPAYSCGTTGISNSYT------------------------------ -----RNPQ-------------------------------------------PLFPPSQINFPSILETSSTDTIIQQQCP AVH---------------------------------------------------------HHMTQHSHMHHNSENRRHSH EIPLHRRNHPYLAMSVPPP-------------------YPLAVNGTIPYRPRYSRRNNPDLE------------------ ----------------------KKRVHKCTHAGCTKAYTKSSHLKAHQRTHT---GEKPYTCNWQGCDW-RFARSDELTR HMRKHTGAKPFKCLVCGRCFSRS---DH-------LSLHMKRHQA----------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Homo_sapiens_KLF6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MDVLPMCSIFQ----------------------ELQIVHETGYFSAL---------- ------------------------------------------------------------------PSLEEYWQQTCLEL ERYLQSEPCYVSASEIK--------------------------------------------------------------- ----------------------------------------FDSQEDLWTKIILAR-EKKE--ESELKISSS--------- -----------------PPEDTLISPS----------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------FCYNLETNSLNSDVSSESSDSSEE---------------------- --LSPTAKFTSDPIGEVL------------VSSGKLSSSVT--------------------------------------- -STPPSSPE---------------------------------------------LSREPS-------------------- ------------------------------------------------------------QLWGCVPGELP--------- SPGKVRSG-----------------------------------TSGKPGDKG---NGDASP------------------- --------------------DGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHT---GEKPYRCSWEGCEW-RFARSDELTR HFRKHTGAKPFKCSHCDRCFSRS---DH-------LALHMKRHL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Mus_musculus_KLF6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------MKLSPALPGTVSART-------------------PDRSP---------------PC FPD-----------SEDCLFQPDMDVLPMCSIFQ----------------------ELQIVHETGYFSAL---------- ------------------------------------------------------------------PSLEEYWQQTCLEL ERYLQSEPCYVSASEIK--------------------------------------------------------------- ----------------------------------------FDSQEDLWTKFILARGEKKE--ESELKISSS--------- -----------------PPEDSLISSS----------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------FNYNLETNSLNSDVSSESSDSSEE---------------------- --LSPTTKFTSDPIGEVL------------VNSGNLSSSVI--------------------------------------- -STPPSSPE---------------------------------------------VNRESS-------------------- ------------------------------------------------------------QLWGCGPGDLP--------- SPGKVRSG-----------------------------------TSGKSGDKG---NGDASP------------------- --------------------DGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHT---GEKPYRCSWEGCEW-RFARSDELTR HFRKHTGAKPFKCSHCDRCFSRS---DH-------LALHMKRHL------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Tetraodon_nigroviridis_KLF6_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MDVLPMCSIFQ----------------------ELQIVHDTGYFSAL---------- ------------------------------------------------------------------PSLEEYWQQTCLEL ERYLQSEP-YVSSSDLK--------------------------------------------------------------- ----------------------------------------FDGQEDLWSKLILACGDKAKA-ECDPKL-AA--------- -----------------APEEDNQDS------------------------------------------------------ -------------------------------------------------------------------------------- ------------------------------------QILDSNSVNSDASSEASDSSEE---------------------- --LSPTHSFTSNPLG-VLVG-----------SGP-FSPSVI--------------------------------------- -STPPSSPE---------------------------------------------ANSEAVGVT----------------- ------------------------------------------------------------TAWGAAHTELH--------- SPGKIRSG------------------------------------AGKSAEKTGLVCGDASP------------------- --------------------DSRRRVHRCQFNGCRKVYTKSSHLKAHQRTHT---GEKPYRCSWEGCEW-RFARSDELTR HFRKHTGAKPFKCSHCDRCFSRS---DH-------LALHMKRHI------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Tetraodon_nigroviridis_KLF6_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------EMDVIPMCSIFQ----------------------ELQIVHDTGYFSAL---------- ------------------------------------------------------------------PSLEEYWQQTCLEL ERYLQSEP-YVSASDLK--------------------------------------------------------------- ----------------------------------------FESQEDLWSKLMLACGDKSK--EPDPKISHI--------- -----------------KDEEDNQDS------------------------------------------------------ -------------------------------------------------------------------------------- ------------------------------------QHLDATGFNSDASSEASDSSEE---------------------- --LSPTLDFSSSSLTDLLG-----------DGSEDLGSAII--------------------------------------- -STPPSSPE---------------------------------------------LGKEVS-VT----------------- ------------------------------------------------------------QGWSGVQTVLH--------- SPGKIRTG---------------------------------------GLERSGLTSGEASP------------------- --------------------DGRKRVHRCQFNGCRKVYTKSSHLKAHQRTHT---GEKPYRCSWEGCEW-RFARSDELTR HFRKHTGAKPFKCSHCDRCFSRS---DH-------LALHMKRHI------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Homo_sapiens_KLF7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MDVLASYSIFQ----------------------ELQLVHDTGYFSAL---------- ------------------------------------------------------------------PSLEETWQQTCLEL ERYLQTEPRRISETFGE--------------------------------------------------------------- ------------------------------------------DLDCFLHASPPPCIEESFR------------------- ------------------RLDPLLLP------------------------------------------------------ -------------------------------------------------------------------------------- --------------------------------------VEAAICEKSSAVDILLSRDK---------------------- --LLSETCLSLQPASSSLDS-------YTAVNQAQLN-AVTS-------------------------------------- -LTPPSSPE---------------------------------------------LSRHLVKTSQTLSAV----------- ----------------------------------------------------------DGTVTLKLVAKKA--------- ALSSVKVGGVAT---------------------------AAAAVTAAGAVKSGQSDSDQGGLGA---------------- ----------------EACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHT---GEKPYKCSWEGCEW-RFARSDELTR HYRKHTGAKPFKCNHCDRCFSRS---DH-------LALHMKRHI------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Mus_musculus_KLF7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MDVLASYSIFQ----------------------ELQLVHDTGYFSAL---------- ------------------------------------------------------------------PSLEETWQQTCLEL ERYLQTEPRRISETFGE--------------------------------------------------------------- ------------------------------------------DLDCFLHASPPPCIEESFR------------------- ------------------RLDPLLLP------------------------------------------------------ -------------------------------------------------------------------------------- --------------------------------------VEATICEKSSAVDILLSRDK---------------------- --LLSETCLSLQPTSSSLDS-------YTAVNQAQLN-AVTS-------------------------------------- -LTPPSSPE---------------------------------------------LSRHLVKTSQTLSAV----------- ----------------------------------------------------------DGTVTLKLVAKKA--------- SLSSVKVGGVA----------------------------AAAAVTPAGAVKSGQSDSEQGGGGA---------------- ----------------DTCPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHT---GEKPYKCSWEGCEW-RFARSDELTR HYRKHTGAKPFKCNHCDRCFSRS---DH-------LALHMKRHI------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Xenopus_tropicalis_KLF7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MDVLASYSIFQ----------------------ELQIVHDTGYFSAM---------- ------------------------------------------------------------------PSLEENWQQTCLEL ERYLQTEPKKMSETFGE--------------------------------------------------------------- ------------------------------------------DLDCFLNTSIAQAVDGTAR------------------- ------------------KIDSIVIP------------------------------------------------------ -------------------------------------------------------------------------------- --------------------------------------VDISAYEKRPSMDVLLSQDK---------------------- --LLSETCVSLQPASSATEC-------YTSVNQAQLN-AVTS-------------------------------------- -LTPPSSPE---------------------------------------------LSRHLVKTPQSLSAV----------- ----------------------------------------------------------DGTVTLKLVAKKA--------- SVSLGKAA---------------------------------ESASTAVTSKCGLSDSEQTGGPG---------------- ----------------EASPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHT---GEKPYKCSWEGCEW-RFARSDELTR HYRKHTGAKPFKCNHCDRCFSRS---DH-------LALHMKRHI------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Tetraodon_nigroviridis_KLF7_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------------------------------------QTCLEL ERYLQTEPKRLSELFDQ--------------------------------------------------------------- ------------------------------------------DLDGLLTPAYLKE-DGEEE------------------- ------------------LSDTLLP------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------SLPSIPEPPSPPPVVLCPAQKNLS------------------ --SSGVMKKDFKPKAQGLEN----VEAVEGVHQAQLS-AVTS-------------------------------------- -LTPPSSPE---------------------------------------------LGRHLVKPNQTLTASA---------- ----------------------------------------------------------DGTLTLKLVARKV--------- GLSAARLVAAH-----------------------------ALP--------VRVKEEDEGAACM---------------- ---------------IGELPENKKRIHRCQFNGCRKVYTKSSHLKAHQRTHT---GEKPYKCSWEGCEW-RFARSDELTR HYRKHTGAKPFKCNHCDRCFSRS---DH-------LALHMKRHI------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Drosophila_melanogaster_KLF7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MDILPSGNIFS----------------------ELERICTTGYYSSQ---------- ------------------------------------------------------------------PSIEDQWQQTCYEL ERYLRDEP---KLQKKM--------------------------------------------------------------- ----------------------------------------HSNLDNPWDIFSTPARLLEELKIKEQHLDTI--------- -----------------STTSSVSSNCSGTSWDSNGSQALSCSVLVKQERIDEEDDDVGCDDKLSVLLAAPPSAIS---- -------------------------------------------------------------------------------- ----------------------------PNPSIGSAGNMTPTSISNSSSISSSNSHSNSNGNTT---------GSSNIIA SPLSSLGSGSTITVSSRNSSAPG--IKVRVVQAKNHPGSNARMHLGHVQ-----------------------DFVLP--- TLTPPSSPESNLRSHNYAQQLEANDLAALIQQQQQQQQQQQQQQQQQQLNPQPGNSTPATAILRFTSQSNPTMTQLQQQQ QQLAVQHLSISPQALGHSNIGSNSPKSSSSSSSNSSNSSSSSHSSSSSISGSSDQPTHSNIPRSTIVRLTT--------- ANGKPGAAGISLARVIQMQNNGNANVAAVLSAAANSGSSNSNSNSSSSNTSSNSINTATPQQQVLSQRSEKSANGSSKPH HPRQ---------HHSDHSPDAKRRIHKCQFLGCKKVYTKSSHLKAHQRTHT---GEKPYKCSWEGCEW-RFARSDELTR HYRKHTGAKPFKCRNCDRCFSRS---DH-------LALHMKRHM------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Homo_sapiens_KLF8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------MVDMDKLINNLEVQLNSEGG------------------- ------------------SMQVFKQVTASVRNRD----------------------PPEIEYRSNMTSPT---LLD---- ------------------------------------------------------ANPMENPALFNDIKIEPPEELLASDF -SLPQVEPVDLSFHKP---------------------------------------------------------------- -KAPLQP---------ASMLQ--------------------APIRPPKPQSSPQTLVVSTSTSDMSTSANIPT------- ----------------VLTPGSVLTSSQ---------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------STGSQQILHVIHTIP-----SVSLPN------------------KM GGLKTIPVVVQSLPMVYTTLPADGGPA--AITVPLIGGDGKNAG------------------------------------ ----SVKVD----PTS--------------------------------------MSPLEIPSDS-EESTIE--------- -------------------------------------------------------------SGSSALQSLQ--------- GLQQEPA-----------------------------------------AMAQMQGEESLDL------------------- ---------------------KRRRIHQCDFAGCSKVYTKSSHLKAHRRIHT---GEKPYKCTWDGCSW-KFARSDELTR HFRKHTGIKPFRCTDCNRSFSRS---DH-------LSLHRRRHDTM---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Mus_musculus_KLF8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MDKFIDNMDVRIKSESG------------------- ------------------SMQVFKQVTGPVPTRD----------------------PSARADRRNMTSPS---FLA---- ------------------------------------------------------ASPMENPALFNDIKIEPPEELLESDF -NMPQVEPVDLSFHKP---------------------------------------------------------------- -KAPLQP---------ASMLQ--------------------APIRPPKPPTAPQAIMVPTS-ADTVTSAAIPT------- ----------------VLTPGSILASSQ---------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------GTGGQPILHVIHTIP-----SVSLPN------------------KM SGLKTIPLVVQSLPMVYTSLPTDGSPA--AITVPLIGGDGKSAG------------------------------------ ----SVKVD----PAS--------------------------------------MCPLEFPSDS-DESAIE--------- -------------------------------------------------------------SGSSALQSLQ--------- GFHHEPA-----------------------------------------TMVHMQGEESLDL------------------- ---------------------KRRRIHQCDFAGCSKVYTKSSHLKAHRRIHT---GEKPYKCTWDGCSW-KFARSDELTR HFRKHTGIKPFRCTDCNRSFSRS---DH-------LSLHRRRHDTM---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Xenopus_tropicalis_KLF8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------------MQIPFIRRVYNSS---PLSSRC- ----------------------------------------------------KMASETPTPAFLSDIKLEPPEQLLDSDC -SLPQAEPVDLSIHKNQ--------------------------------------------------------------- -KTSLRQS--------SSPPS--------------------SSPMVLGTPLSAPPSIVSLSGLG----SAVPA------- ----------------VLSPGSILASTQ---------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------GSGGQQILHVLHTIP-----SVNLPS------------------KM GNLQTIPVVVQSLPVVYTTLPTDGMTA--ALTVPLLGPDGKVTGRSHNLLM--------RSQASEVEDFDLRADQSP--- CDLGSMSLS----AHSSVKA--------------------------------ELESPVEINSDS-DDSIVE--------- --------------------------------------------------------------ASPSFPDTA--------- --HGTRL-----------------------------------------MRMQRGGAGSPDM------------------- ---------------------RKRRVHQCDFEGCNKVYTKSSHLKAHRRIHT---GEKPYKCTWEGCTW-KFARSDELTR HFRKHTGIKPFLCSDCDRSFSRS---DH-------LALHRRRHIMM---------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Homo_sapiens_KLF9 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MSAAAYMD-----------------------FVAAQCLVSISNRAAVP--------- --------------------------------------------------------------EHGVAPDAER-------- ----LRLP-EREVTKE---------------------------------------------------------------- ----------------------------------------HGDPGDTWKDYCTLVTIAKSLLDLNKYRPIQ--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------TPSVC-SDSLESPD-------------------------- --------------EDMGSDS----------DVTTESGSS---------------------------------------- -------------------------------------------------------PSHSPEERQDPGS------------ -------------------------------------------------------------------------------- ----------------------------------------------APSPLSLLHPGVAAKGK----------------- --------------------HASEKRHKCPYSGCGKVYGKSSHLKAHYRVHT---GERPFPCTWPDCLK-KFSRSDELTR HYRTHTGEKQFRCPLCEKRFMRSD----------HLTKHARRHT-----------------------EFHPSMIKRS--- -------------------------------------KKALANAL----------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Mus_musculus_KLF9 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MSAAAYMD-----------------------FVAAQCLVSISNRAAVP--------- --------------------------------------------------------------EHGGAPEAER-------- ----LRLP-EREVTKE---------------------------------------------------------------- ----------------------------------------HGDPGDTWKDYCTLVTIAKSLLDLNKYRPIQ--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------TPSVC-SDSLESPD-------------------------- --------------EDIGSDS----------DVTTESGSS---------------------------------------- -------------------------------------------------------PSHSPEERQDSGS------------ -------------------------------------------------------------------------------- ----------------------------------------------APSPLSLLHSGVASKGK----------------- --------------------HASEKRHKCPYSGCGKVYGKSSHLKAHYRVHT---GERPFPCTWPDCLK-KFSRSDELTR HYRTHTGEKQFRCPLCEKRFMRSD----------HLTKHARRHT-----------------------EFHPSMIKRS--- -------------------------------------KKALASPL----------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Xenopus_tropicalis_KLF9 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MTAVAYSD-----------------------FVAAQCLVSISNRKAVPPQEEVEGPL YSALDSRPT----------------------------------------------PAHSPALHLRNMPEQEAA------- ----LHLP-EPGPNKEH--------------------------------------------------------------- ----------------------------------------HDGPGEAWKDYCTLLTIAKSLLELNKYRPLP--------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------SP------AYSHSD-------------------------- --------------EELCSDS----------DVTTESGLSFS-------------------------------------- -------------------------------------------------------PSHSPGSCSSSTTPSHM-------- -------------------------------------------------------------------------------- ---------------------------------------DYSPEPGSTQPLPLTQDAPKSPTRPLGKDTAPV-------- -------------------RSTNEKRHRCPYAGCGKVYGKSSHLKAHYRVHT---GERPFPCTWPDCLK-KFSRSDELTR HYRTHTGEKQFRCPLCEKRFMRSD----------HLTKHARRHT-----------------------DFHPSMIKRS--- -------------------------------------KRSNSSFT----------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Ciona_intestinalis_KLF9 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------MRSLPASPTNSTCEFETSCCTPSNMEQFAHQCQRAD LSDSDSRSRHSSDSCTGCNDCEAADTLLSLCGGQTNQLNGS----------RKPVLPPRLRYRKKYRQTFLDESE-NNSR SASSPSHHT----------------------------------------------AITTMSTPPYTPPPPVVD------- --TQHAITHLTNAQPTMTMTSKPAHTTVTGS------------------------------------------------- -----------------------------HGNDSSHSDTCSCCTDNELSNKDYLLYAPPSLSASCCDSPTMVDTATTRP- ------YSPTLNTPVYLTPAASPAN----SEVSPTSG-SESTKDECSDMDTD---------------------------- -------------------------------------------------------------------------------- -----------------DSENDKPAEKPEPETQFPSDSKPPTFAPFFMPTISQPTAIPASSI------------QPIKLL HNGSGQFLPITANSNIHTMPI----------VIMGNMQA--------------LHQSSS-----------AVLLMVN--- ---------------------------------------------------PQDQQQQHANFTLPPVIDTTKV------- -------------------------------------------------------------------------------- --------------------------------------KTEYLPPTTQPTQKLCTLAPAPLALRVTPPTSPVDFTQ--SP Y----------MATDKISSDTNRRRSHICTYENCGKTYFKSSHLKAHLRTHT---GEKPFKCQWENCGK-CFARSDELSR HRRTHTGEKRFACPICDRRFMRSD----------HLTKHMKRHNGN-----------------RKIPNWQKEINKLSSSP RTSDPPTLLPSNTSCPTPVGYTPTSIPTTPSCRNQIKIAPKTVQASAPAKVIQYVSLATTTPCRLPLMTATTS------- -------------------------------------------------------------------------------- ------------------------------------------------------- >Homo_sapiens_KLF10 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