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-------------------------------------------------------------------------------- ---------------------MSKK---GRSKGEKPEMETDAVQMANEELRAKLT-----------SIQIEFQQEKSK-- VGKL-RERLQ-EAKLEREQEQRRHTAYISELKAKLHEEKT-----------------------KELQALREGLIRQHEQE AARTAKIKEGELQRLQA---------TLNVLRDGAADKVKTALLTEAREEARRA------------------FDGERLRL QQEILELKAAR-------------KQAEEALSNCMQAD-------------------------------KTKAADLRAAY QAHQDEVHRIKREC----------ERD---IRRLMDEIKGKDRVI----LALEKELG----------------------- ----VQAGQTQKLLLQKEALDEQL----------------VQVKEAER-HHSSPKRELPPGIGDMVE---LMGVQDQHMD ER----------------DVRRFQLKIAELNSVIRKLEDRNTLLADERNELL--------------------------KR SRETEVQLKPLVEKNK------------RMNKKNE----DLLQSIQRMEEKIKNLTRENVEMKEK------------LSA QASLKRHTSLNDLSLT--------------RDEQEIEFLRLQVLEQQHVIDDLSL------------------------- -----------------------------------------ERERLLRSKRHRGKSLKPPKK------------------ -----------------HVVETFFG-FDEESVDSETLSETSYNTD----------RTDRTPATPEED--LDD-------- ------------ATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA-----------------------RTR EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD--------LLEKIYRLEMEENQLKNEMQDAKD----- ---------QNELLEFRVLELE---------------------------------------------------------- ---ERERRSPAFNL------------------------------------QITTF------------------------- -----------------------------PENHSSALQLFCHQEGVKDVNVSELMKKLDILGDN---------------G NLRNEEQVAIIQAG---------TVLALCEK--WLKQIEGTEAAL----TQKMLDLEKEKDLFSRQKGYLEEELDYRKQA ----LDQAYLK-------IQDLEATLYTALQ------QEPGR----------RAGEALSE------GQREDLQAAVEKVR R--QILRQSREFDSQILRER-------------------MELLQQAQ---QRIRELED---KLEFQKRHLKELEEKFLFL FLFFS-------------LAFILWP------------------------------------------------------- ------ >Pan_troglodytes_JAKMIP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MSKK---GRSKGEKPEMETDAVQMANEELRAKLT-----------SIQIEFQQEKSK-- VGKL-RERLQ-EAKLEREQEQRRHTAYISELKAKLHEEKT-----------------------KELQA------------ --------EG-LQRLQA---------TLNVLRDGAADKVKTALLTEAREEARRA------------------FDGERLRL QQEILELKAAR-------------KQAEEALSNCMQAD-------------------------------KTKAADLRAAY QAHQDEVHRIKREC----------ERD---IRRLMDEIKGKDRVI----LALEKELG----------------------- ----VQAGQTQKLLLQKEALDEQL----------------VQVKEAER-HHSSPKRELPPGIGDMVE---LMGVQDQHMD ER----------------DVRRFQLKIAELNSVIRKLEDRNTLLADERNELL--------------------------KR SRETEVQLKPLVEKNK------------RMNKKNE----DLLQSIQRMEEKIKNLTRENVEMKEK------------LSA QASLKRHTSLNDLSLT--------------RDEQEIEFLRLQVLEQQHVIDDLSL------------------------- -----------------------------------------ERERLLRSKRHRGKSLKPPKK------------------ -----------------HVVETFFG-FDEESVDSETLSETSYNTD----------RTDRTPATPEED--LDD-------- ------------ATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA-----------------------RTR EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD--------LLEKIYRLEMEENQLKNEMQDAKD----- ---------QNELLEFRVLELE---------------------------------------------------------- ---ERERRSPAFNL------------------------------------QITTF------------------------- -----------------------------PENHSSALQLFCHQEGVKDVNVSELMKKLDILGDN---------------G NLRNEEQVAIIQAG---------TVLALCEK--WLKQIEGTEAAL----TQKMLDLEKEKDLFSRQKGYLEEELDYRKQA ----LDQAYLK-------IQDLEATLYTALQ------QEPGR----------RAGEALSE------GQREDLQAAVEKVR R--QILRQSREFDSQILRER-------------------MELLQQAQ---QRIRELEA---KLEFQKRHLKELEEKFLFL FLFFS-------------LAFILWP------------------------------------------------------- ------ >Gorilla_gorilla_JAKMIP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MSKK---GRSKGEKPEMETDAVQMANEELRAKLT-----------SIQIEFQQEKSK-- VGKL-RERLQ-EAKLEREQEQRRHTAYISELKAKLHEEKT-----------------------KELQALREGLIRQHEQE AARTAKIKEGELQRLQA---------TLNVLRDGAADKVKTALLTEAREEARRA------------------FDGERLRL QQEILELKAAR-------------KQAEEALSNCMQAD-------------------------------KTKAADLRAAY QAHQDEVHRIKREC----------ERD---IRRLMDEIKGKDRVI----LALEKELG----------------------- ----VQAGQTQKLLLQKEALDEQL----------------VQVKEAER-HHSSPKRELPPGIGDMVE---LMGVQDQHMD ER----------------DVRRFQLKIAELNSVIRKLEDRNTLLADERNELL--------------------------KR SRETEVQLKPLVEKNK------------RMNKKNE----DLLQSIQRMEEKIKNLTRENVEMKEK------------LSA QASLKRHTSLNDLSLT--------------RDEQEIEFLRLQVLEQQHVIDDLSL------------------------- -----------------------------------------ERERLLRSKRHRGKSLKPPKK------------------ -----------------HVVETFFG-FDEESVDSETLSETSYNTD----------RTDRTPATPEED--LDD-------- ------------ATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA-----------------------RTR EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD--------LLEKIYRLEMEENQLKNEMQDAKD----- ---------QNELLEFRVLELE---------------------------------------------------------- ---ERERRSPAFNL------------------------------------QITTF------------------------- -----------------------------PENHSSALQLFCHQEGVKDVNVSELMKKLDILGDN---------------G NLRNEEQVAIIQAG---------TVLALCEK--WLKQIEGTEAAL----TQKMLDLEKEKDLFSRQKGYLEEELDYRKQA ----LDQAYLK-------IQDLEATLYTALQ------QEPGR----------RAGEALSE------GQREDLQAAVEKVR R--QILRQSREFDSQILRER-------------------MELLQQAQ---QRIRELED---KLEFQKRHLKELEEKFLFL FLFFS-------------LAFILWP------------------------------------------------------- ------ >Macaca_mulatta_JAKMIP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MSKK---GRSKGEKPEMETDAVQMANEELRAKLT-----------SIQIEFQQEKSK-- VGKL-RERLQ-EAKLEREQEQRRHTAYISELKAKLHEEKT-----------------------KELQALREGLIRQHEQE AARTAKIKEGELQRLQA---------TLNVLRDGAADKVKTALLTEAREEARRA------------------FDGERLRL QQEILELKAAR-------------KQAEEALSNCMQAD-------------------------------KTKAADLRAAY QAHQDEVHRIKREC----------ERD---IRRLMDEIKGKDRVI----LALEKELG----------------------- ----VQAGQTQKLLLQKEALDEQL----------------VQVKEAER-HHSSPKRELPPGIGDMVE---LMGVQDQHMD ER----------------DVRRFQLKIAELNSVIRKLEDRNTLLADERNELL--------------------------KR SRETEVQLKPLVEKNK------------RMNKKNE----DLLQSIQRMEEKIKNLTRENVEMKEK------------LSA QASLKRHTSLNDLSLT--------------RDEQEIEFLRLQVLEQQHVIDDLSL------------------------- -----------------------------------------ERERLLRSKRHRGKSLKPPKK------------------ -----------------HVVETFFG-FDEESVDSETLSETSYNTD----------RTDRTPATPEED--LDD-------- ------------TTAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA-----------------------RTR EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD--------LLEKIYRLEMEENQLKNEMQDAKD----- ---------QNELLEFRVLELE---------------------------------------------------------- ---VRDS------------------------------------------------------------------------- --------------------------------------ICCKLSNGADILFEPKLKFM---------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MSKK---GRSKGDKPEAETDSVQMANEELRAKLT-----------NIQIEFQQEKSK-- VGKL-RERLQ-EAKLEREQEQRRHTAYISELKAKLHEEKT-----------------------KELQALREALIRQHEQE AARTAKIKEGELQRLQA---------TLNVLRDGAADKVKTALLADAREEARRT------------------FDGERQRL QQEILELKAAR-------------KQAEEALSNCMQAD-------------------------------KAKAADLRAAY QAHQDEVHRIKREC----------ERD---IRRLMDEIKGKERVI----LALEKELG----------------------- ----VQTGQTQRLLLQKEALDEQL----------------VQVKEAER-HHSSPKRELPPGIGDMAE---LMGGQDQHMD ER----------------DVRRFQLKIAELNSVIRKLEDRNTLLADERNELL--------------------------KR SRETEVQLKPLVEKNK------------RMNKKNE----ELLHSIQRMEEKLKSLTRENVEMKEK------------LSA QASLKRHTSLNDLSLT--------------RDEQEIEFLRLQVLEQQHVIDDLSL------------------------- -----------------------------------------ERERLLRSKRHRGKSLKPPKK------------------ -----------------HVVETFFG-FDEESVDSETLSETSYNTD----------RTDRTPATPEED--LDE-------- ------------TTTREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA-----------------------RTR EQLQADLLRCQAKIEDLEKLLVEKGQDAAWVEEKQVLMRTNQD--------LLEKIYRLEMEENQLKSEMQDAKD----- ---------QNELLEFRVLELE---------------------------------------------------------- ---ERERRSPAFNL------------------------------------QITTF------------------------- -----------------------------PENNSSALQLFCHQEGVKGVNISELMKNLDILGDN---------------G NLRNEEQVAVIQAG---------TVLALCEK--WLKQIEGTEAAL----TQKMMDLEKEKDQFSRQKGYLEQELDYRKEA ----LDQAYLK-------IQDLEATLYNALQ------QEPGR----------RASEALSA------SQREDLQAAVEKVR R--QLLRQSREFDSQILRER-------------------MELLQQAQ---QKIREMEG---KLELQRRQLKELEEKFLFL FLFFS-------------LAFILWP------------------------------------------------------- ------ >Rattus_norvegicus_JAKMIP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- ---------------------MSKK---GRSKGEKPETETDSVQMANEELRAKLT-----------NIQIEFQQEKSK-- VGKL-RERLQ-EAKLEREQEQRRHTAYISELKAKLHEEKT-----------------------KELQALREALIRQHEQE AARTAKIKEGELQRLQA---------TLNVLRDGAADKVKTALLADAREEARRT------------------FDGERQRL QQEILELKAAR-------------KQAEEALSNCMQAD-------------------------------KAKAADLRAAY QAHQDEVHRIKREC----------ERD---IRRLMDEIKGKERVI----LALEKELG----------------------- ----VQAGQTQRLLLQKEALDEQL----------------VQVKEAER-HHSSPKRELPPGIGDMAE---LMGGQDQHMD ER----------------DVRRFQLKIAELNSVIRKLEDRNTLLADERNELL--------------------------KR SRETEVQLKPLVEKNK------------RMNKKNE----DLLHSIQRMEEKLKSLTRENVEMKEK------------LSA QASLKRHTSLNDLSLT--------------RDEQEIEFLRLQVLEQQHVIDDLSL------------------------- -----------------------------------------ERERLLRSKRHRGKSLKPPKK------------------ -----------------HVVETFFG-FDEESVDSETLSETSYNTD----------RTDRTPATPEED--LDE-------- ------------TTTREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA-----------------------RTR EQLQADLLRCQAKIEDLEKLLVEKGQDAAWVEEKQVLMRTNQD--------LLEKIYRLEMEENQLKSEMQDAKD----- ---------QNELLEFRVLELE---------------------------------------------------------- ---VRDS------------------------------------------------------------------------- --------------------------------------ICCKLSNGADILFEPKLKFV---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------ >Canis_familiaris_JAKMIP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MSKK---SRNKGEKPEMEADAVQMANEELRAKLT-----------SIQIEFQQEKSK-- VGKL-RERLQ-EAKLEREQEQRRHTAYISELRAKLHEEKT-----------------------KELQALREVLIRQHEQE AARTAKIKEGELQRLQA---------TLNVLRDGAADKVKTALLAEAREEARRT------------------FDGERLRL QQEILELKAAR-------------KQAEEALSNCMQAD-------------------------------KTKAADLRAAY QAHQDEVHRIKREC----------ERD---IRRLMDEIRGKDRVI----LALEKELG----------------------- ----VQTGQTQKLLLQKEALDEQL----------------VQVKEAER-YHSSPKRELPPGIGDMAE---LMGVQDQHMD ER----------------DVRRFQLKIAELNSVIRKLEDRNTLLADERNELL--------------------------KR SRETEVQLKPLVEKNK------------RMNKKNE----DLLQSIQRMEEKIKNLTRENVEMKEK------------LSA QASLKRHTSLNDLSLT--------------RDEQEIEFLRLQVLEQQHVIDDLSL------------------------- -----------------------------------------ERERLLRSKRHRGKSLKPPKK------------------ -----------------HVVETFFG-FDEESVDSETLSETSCNTD----------RTDRAPATPEED--LED-------- ------------TTTREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA-----------------------RTR EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD--------LLEKIYRLEMEESQLKNEMQDAKD----- ---------QNELLEFRVLELE---------------------------------------------------------- ---ERERRSPAFNL------------------------------------QITTF------------------------- -----------------------------PENNSSALQLFCHQEGVKDVNVSELMKKLDILGDN---------------G NLRNEEQVAIIQAG---------TVLALCEK--WLKQIEGTEAAL----TQKMLDLEREKDLFSRQKGYLEEELDYRKEA ----LDQAYLK-------IQELEATLYNALQ------QEPGR----------RASEALSE------GQREDLQAAVEKVR R--QILRQSREFDSQVLRER-------------------MELLQQAQ---QRIRELEA---KLEIQKRHLKELEEKFLFL FLFFS-------------LAFILWP------------------------------------------------------- ------ >Felis_catus_JAKMIP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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-------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------MSKK---GRSKGERPEMETDAVQMANEELRAKLT-----------SIQIEFQQEKSK-- VGGV-RAPQL-RGRXXREQEQRRHTAYISELRAKLHEEKT-----------------------KELQALREVLIRQHEQE AARTAKIKEGELQRLQA---------TLNVLRDGAADKVKTALLAEARDEARRA------------------FDGERQRL QQEILELKASR-------------KQAEEALSNCMQAD-------------------------------KTKAADLRAAY QAHQDEVHRIKREC----------ERD---IRRLMDEIRGKDRVI----LALEKELG----------------------- ----VQTGQTQKLLLQKEALDEQL----------------VQVKEAER-YHSSPKRELPPGIGDMAE---LMGVQDQHMD ER----------------DVRRFQLKIAELNSVIRKLEDRNTLLADERNELL--------------------------KR SRETEVQLKPLVEKNK------------RMNKKNE----DLLQSIQRMEEKIKSVMRENVEMKEK------------LSA QASLKRHTSLNDLSLT--------------RDEQEIEFLRLQVLEQQHVIDDLSL------------------------- -----------------------------------------ERERLLRSKRHRGKGLKPPKK------------------ -----------------HVVETFFG-FDEESVDSETLSETSCNTD----------RTDRAPATPEED--LDD-------- ------------TTTREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA-----------------------RTR EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD--------LLEKIYRLEMEESQLKNEMQDAKD----- ---------QNELLEFRVLELE---------------------------------------------------------- ---ERERRSPAFNL------------------------------------QISTF------------------------- -----------------------------PENNRSALQLFCHQEGVKDVNVSELMKKLDILGDN---------------G NLRNEEQVAIIQAG---------TVLALCEK--WLKQIEGTEAAL----TQKMLDLEKEKDLFSRQKGYLEEELDYRKEA ----LDQAYLK-------IQELEATLYNALQ------QDPGR----------RASEALSE------GQREDLQAAVEKVR R--QILRQSREFDSQVLRER-------------------MELLQQAQ---QRIRELEG---KLEVQKKHLKELEEKFLFL FLFFS-------------LAFILWP------------------------------------------------------- ------ >Bos_taurus_JAKMIP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- 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