>Homo_sapiens_HTRA1 ------------------------------------------------MQIPRAALLP-------LLLLLLAAPASAQLS RAGRSAPL----AAGCPDRCEPARCPPQPE-HCEGGRARDACGCCEVCGAPEGAACGL----QEGPCGEGLQCVVPF--- GVPASATVRRRAQAGLCVCAS---SEPVCGSDA----------------------------------------------- ----NTYANLCQLRAASRRSERLHRPPVIVLQRGACG------QGQEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK- --LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA KIKDVDEKADIALIK--------------IDHQGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP----- -----------------DVISGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSANDVSDVIKRE-STLNMV VR-RGNEDIMITVIPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Pan_troglodytes_HTRA1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------QEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK- --LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA KIKDVDEKADIALIK--------------IDHQGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP----- -----------------DVISGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSANDVSDVIKRE-STLNMV VR-RGNEDIMITVIPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Gorilla_gorilla_HTRA1 ------------------------------------------------MQIPRAALLPL------LLLLLLAAPASAQLS RAGRSAPL----AAGCPDRCEPARCPPQPQ-HCEGGRARDACGCCEVCGAPEGAACGL----QEGPCGEGLQCVVPF--- GVPASATVRRRAQAGLCVCAS---SEPVCGSDA----------------------------------------------- ----NTYANLCQLRAASRRSERLQLPPVIVLQRGACG------QGQEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK- --LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA KIKDVDEKADIALIK--------------IDHQGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP----- -----------------DVISGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSANDVSDVIKRE-STLNMV VR-RGNEDIMITVIPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Macaca_mulatta_HTRA1 ------------------------------------------------MQIPRAALLPL------LLLLLLAAPASAQLS RAGRSAPL----ATGCPERCEPARCPPQPE-HCEGGRARDACGCCEVCGAPEGAACGL----QEGPCGEGLQCVVPF--- GVPASATVRRRAQAGLCVCAS---NEPVCGSDA----------------------------------------------- ----NTYANLCQLRAASRRSERLHRPPVIVLQRGACG------QGQEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK- --LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA KIKDVDEKADIALIK--------------IDHQGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP----- -----------------DVISGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSANDVSDVIKRE-STLNMV VR-RGNEDIMITVIPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Mus_musculus_HTRA1 ------------------------------------------------MQSLRTTLLS-------LLLLLLAAPSLALPS GTGRSAPA----ATVCPEHCDPTRCAPPPT-DCEGGRVRDACGCCEVCGALEGAACGL----QEGPCGEGLQCVVPF--- GVPASATVRRRAQAGLCVCAS---SEPVCGSDA----------------------------------------------- ----KTYTNLCQLRAASRRSEKLRQPPVIVLQRGACG------QGQEDPNSLRHKYN-FIADVVEKIAPAVVHIELYRK- --LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKNRVKVELKNGAT-----------------YEA KIKDVDEKADIALIK--------------IDHQGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKAVTKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP----- -----------------DVLSGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVTANDVSDVIKKE-NTLNMV VR-RGNEDIVITVIPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Rattus_norvegicus_HTRA1 ------------------------------------------------MQFLRTALLS-------LLLLLLAAPSLALPS GISRSAPA----ATVCPEHCDPTRCAPPPT-DCEGGRVRDACGCCEVCGALEGAVCGL----QEGPCGEGLQCVVPF--- GVPASATVRRRAQAGLCVCAS---SEPVCGSDA----------------------------------------------- ----KTYTNLCQLRAASRRSEKLRQPPVIVLQRGACG------QGQEDPNSLRHKYN-FIADVVEKIAPAVVHIELYRK- --LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKNRVKVELKNGAT-----------------YEA KIKDVDEKADIALIK--------------IDHQGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKTVTKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP----- -----------------DVISGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVTANDVSDVIKKE-NTLNMV VR-RGNEDIVITVVPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Canis_familiaris_HTRA1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------GACG------EGQEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK- --LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA KIKDVDEKADIALIK--------------IDHEGR-----LPVLLLGRSSELR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDHHRDFP----- -----------------DVLSGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSASDVSDVIKKE-NTLNMV VR-RGNEDIMITVIPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Felis_catus_HTRA1 -------------------------------------------------------------------------------- -------------------------------------------HRPYLGLVMDG-------------------------- -------------------------------------------------------------------------------- ----------------------------------FAG------QWQEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK- --LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA KIKDVDEKADIALIK--------------IDHEGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP----- -----------------DVLSGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSANDVSDVIKKE-STLNMV VR-RGNEDIMITVIPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Equus_caballus_HTRA1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------GQEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK- --LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA KIKDVDEKADIALIK--------------IDHEGN-----LPVLLLGRSSELR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP----- -----------------DVLSGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSANDVSDVIKKE-STLNMV VR-RGNEDIMITVIPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Gallus_gallus_HTRA1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------XRRAERLRQPPIIAIQRGGCG------QGQEHPNSLRHKYN-FIADVVEKIAPAVVHIELFRK- --LPYSK-REIPVASGSG----FIVS-EDGLIVTNAHVV------TNKNRVKVELKNGET-----------------YEA KIKDVDEKADIALIK--------------IDAQGK-----LPVLLLGQSGDLR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKAITKKKYIGIRMMSLTP----------------------SKAGELKDRHKDFP----- -----------------DVVSGAYVIDVIPETPAE---AGGLKDNDVIISINGQ----SITSASDVSDIIKKD-STLNMV VR-RGNEDVMLTVIPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Taeniopygia_guttata_HTRA1 -------------------------------------------------------------------------------- ----------SALPACPERCDRSRCPALPA-GCPGGPVPDACGCCRVCGAEEGEACGG----AGPPCGEGLQCVLPPG-- AVPASATVRKRAAAGRCQCTS---SEPVCGSDA----------------------------------------------- ----VTYASHCQLRAASRRAESLRQPPIIAIQRGACG------QGQEHPNSLRHKYN-FIADVVEKIAPAVVHIELFRK- --LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKNRVKVELKNGET-----------------YEA KIKDVDEKSDIALIK--------------IDSQGK-----LPVLLLGQSADLR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKAVTKKKYIGIRMMSLTP----------------------SKARELKDRHKDFP----- -----------------DVVSGAYVIEVIPETPAE---AGGLKDNDVIISINGQ----SISSASDVSDIIKKD-STLHMV VR-RGNEDVMLTIVPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Danio_rerio_HTRA1a ----------------------------------------------------------------MRLLILCASIILVP-- LLCDARIIKRYVIG-CPERCDKSLCPPIPP-DCLAGDILDQCDCCPVCAAGEGESCGGTGKLGDPECGEGLECAVSD--- GVGATTTVRRRGKTGVCVCKS---SEPVCGSDG----------------------------------------------- ----VSYRNICELKRVSNRAQKLQQPPIIFIQRGACGK-----GHEENPDSLRHRYN-FIADVVEKIAPAVVHIELFRK- --NVFN--REVAVASGSG----FVVS-EDGLIVTNAHVV------ANKHRVKVELKTGTT-----------------YDA KIKDVDEKADIALIK--------------IDAPMK-----LPVLLLGRSADLR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIRQFLAESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKTATKKKYIGVRMMTLTP----------------------TLAKELKQRKNDFP----- -----------------DVTSGAYVIEVIPKTPAE---VGGLKESDVIISINGQ----RITSASDVSTAIKTD-ESLRAV VR-RGNEDIILTIIPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Danio_rerio_HTRA1b ---------------------------------------------------------------MILVTLFCICALVTS-- LQADARLSKRYVIGGCPSHCDKSMCPTMPK-DCSTGQVMDHCNCCLVCASGEGEACGGVGKLGDPVCGESLECSVTG--- GVSYSATVRRRGKQGVCVCKS---SDPVCGSDG----------------------------------------------- ----VSYRDICELKRVSNRAQSLQQPPVLFIQRGACGT-----SLHDNPNSLRYKYN-FIADVVEKIAPAVVHIELYRK- --MVYSK-REMAVASGSG----FVVS-DDGLIVTNAHVV------ANKNRVKVELKNGAS-----------------YDA KIKDVDEKADIALIK--------------IDLPNK-----LPVLLLGRSADLR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIRQFLAESYDRLAR---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GRGTTKKRYIGVRMMTLTP----------------------SLSKELKGRLRDFP----- -----------------DITSGAYVIEVISKTPAA---AGGLKEHDVIISINGQ----RISTATDVSAIIKKE-SSLRVV VR-RGNEDIILTIIPMEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Takifugu_rubripes_HTRA1a --------------------------------------------------------MFFMQLYMFWSLSLCVIAAFAP-- VPAYAQSSNRFVVG-CPSRCDKSMCPRPPA-DCAAGQTLDVCNCCPVCASGEGEACGSNGKLGDPVCGEGLECSVTG--- GVAYTITVRRRSKSGTCMCKS---SEPVCGSDG----------------------------------------------- ----VSYRNICELKRVSRRAQKLQQPPVLFIQRGACG------KAQNNPESPRHKYN-FIADVVERIAPSVVHIELFRK- --MTYSK-REVPVASGSG----FVVS-EDGQIVTNAHVV------ANKHRVKVELKSGGS-----------------YDA KIKDVDEKSDIALIK--------------IDTPVK-----LPVLLLGRSSDLR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGRELGLRNS--------DMEYIQTDAIIN--YGNSGGPLINLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIREFLAESYDRQSR---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GRTTAKKKYIGVRMMTLTP----------------------ALSKELKTQHRDFP----- -----------------DITSGAYVMEVIAKTPAA---IGGLKEHDVIISINGQ----RISSASDVSTAIKKD-NKLSIV VR-RGNEDLILTVVPVEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Tetraodon_nigroviridis_HTRA1a ----------------------------------------------------RLISESFHSPIMRLGLLLCALAMLV--- --AEARIVKRLAIG-CPEKCDKSQCAPIPA-DCLAGDALDRCDCCPVCASGEGEQCGGSG---DRDCAEGMECLVAD--- GVEVSATVRKRGAAGLCVCTS---SEPVCGSDG----------------------------------------------- ----VSYRNICELKRVSNRAVKLQRPPVILIQRGACG------EGQQNPDSLRYKYN-FIADVVEKIAPAVVHIELYRK- --TIFTK-REVAVASGSG----FVVS-EDGLIVTNAHVV------ANKHRVKVELKSGAT-----------------FDA KIRDVDEKADIALIK--------------IDAPMK-----LPVLLLGRSADLR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIRQFLAESHDRQAR---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GQTVQKKKYIGIRMMSLTP----------------------TLAKDLKERQSDFP----- -----------------DVTSGVYVIEVISRTPAE---RAGLHEKDVIISINGE----PISLASDVSDAIKGG-DALRMV VR-RGNEDVILTVVPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Tetraodon_nigroviridis_HTRA1b -------------------------------------------------------VAQLPSANMFWWLSLCAVAALA--- ---EAQSSGRFVVG-CPARCDKSTCPRPPA-DCAAGQTLDACRCCPVCASGEGEACGGTGKLGDPVCGDGLECSVPG--- GVAHSGTVRRRSRSGTCTCKA---SEPVCGSDG----------------------------------------------- ----VSYRNTCELRRASRRAQRLLQPPVLFVQRGACG------KAQDNPDSPRHKYN-FIADVVEKIAPSVVHIELFRK- --MTYSK-REVPVASGSG----FVVS-EDGQIVTNAHVV------ANKHRVKVELQSGGS-----------------YDA KIQDVDERSDIALIK--------------IAAPTK-----LPVLLLGRSSDLR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGRELGLQNS--------DMDYIQTDAIIN--YGNSGGPLINLDG-----EVVGINT LKVT----AGISFAIP-------------------------SDKIREFLAESYDRQSR---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GRTAAKKKYIGVRMMTLTP----------------------ALAKELKTQHRDFP----- -----------------DITSGAYVMEVIAKTPAA---VGGLKEHDVIISINGQ----RISSASDVSAAIKKD-NKLSVV VR-RGNEDLILTVVPVEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Gasterosteus_aculeatus_HTRA1a ---------------------------------------------------------------MSLRLVLCVMALLVRPP PAAGARRAKRFAIG-CPEKCDVSVCAPIPA-DCPAGDALDHCDCCPVCASGEGEQCGGTA---RRECAEGMECAVTG--- GVEASATVRRRGAAGVCSCTS---SDPACGSDG----------------------------------------------- ----VSYRNICELKRVSNRAMKLRQPPVIFIQRGTCG------QGQQNPDSLRLKYN-FIADVVQKIAPAVVHIELYRK- --MMFSK-REVAVASGSG----FVVS-EDGLIVTNAHVV------ANKHRVKVELKSGAT-----------------FDA RIKDVDEKADIAVIE--------------IDAPMK-----LPVLLLGRSADLR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DIDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVA----AGISFAIP-------------------------SDKIRQFLVESHARQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKTYQKNKYVGVRMMSLTP----------------------ALTKELKEKQSDFP----- -----------------DITSGAYVIEVIGRTPAE---AAGLQEKDVIISINGE----PIASASDVSAAIRRD-DTLRTV VR-RGNEDVLLSIVPEEIEP------------------------------------------------------------ -------------------------------------------------------------------------- >Gasterosteus_aculeatus_HTRA1b -------------------------------------------------------------------------------- ---------------------------MPA-HCPAGQILDACHCCQVCASGEGEACGGLGKLGDPVCGEGLECSVSA--- GVAYTTTVRRRSKSGTCACKS---AEPVCGSDG----------------------------------------------- ----VSYRNVCELKRVSRRAQKLQQPPVVLIQRGACG------KARDNPDSPRHKYN-FIADVVEKIAPSVVHIELFRK- --MTYSK-REVAVASGSG----FVVA-EDGQIVTNAHVV------ANKHRVKVELKSGGT-----------------YDA KIKDVDEKSDIALIK--------------IDVPTK-----LPVLPLGRSSNLR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGRELGLRNS--------DMEYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIREFLAEAYDRLSR---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GRAAAKKKYIGVRMMTLTP----------------------SLAKELKTRHLDFP----- -----------------DITSGAYVMEVIAKTPAA---VAGLKEHDVIISVNGQ----RISSATDVSAAVKRD-GSLRVV VR-RGNEDAILTVVPMEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Oryzias_latipes_HTRA1a ---------------------------------------------------------------MQLRLPVCVTALFASSW LLAEAQIVKRAAIG-CPERCDRSACAPVLQ-DCLSGDELDRCGCCPVCASGEGAPCGAPG---DQECVEGMECVVTD--- GVEASATVRRRARAGVCTCIS---TDPVCGSDG----------------------------------------------- ----VSYRNVCELKRVSSRATELQQPPVIFIQRGACG------KGQQSPDSLRYKYN-FIADVVEKIAPAVVHIELFRK- --MVFSK-REVSVASGSG----FVVS-EDGLIVTNAHVV------ANKHRVKVELKSGAT-----------------YDA KIKDIDEKADIALIK--------------IDTPNK-----LPVLLLGRSADLR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKILQFLAESHDRQAK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GKTLAKKKYIGVRMMSLTP----------------------TLAKELKARHPDFP----- -----------------DLTSGAYVMEVIGRTPAE---AAGLKERDVIISINGE----HITSANDVSTTIKRE-QNLRMV VR-RGNEDVMLTVIPEEIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Ciona_intestinalis_HTRA1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------GAGNTGGNTRRGAFN-FVADVVQVAGPAVVHIERLVN- --VPFTR-RAVAVSNGSG----FLVE-SNGLIITNAHVVG------NQSALNVKLQDGRE-----------------FEG QVIGIDEARDIAAVK--------------INCTG------LPKIPLGTTRDLR------PGEWVVAIGSPLA-------- ---LKNTVTAGI-----VSNMCRAGKELGLRDE---EK--RDMEYIQTDATIN--VGNSGGPLVNLDG-----EVIGINS MMAS----AGIGFAIP-------------------------IDYVRDFLQQLEHGQQTRVQ------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------HTRRWIGVSMLSLTP----------------------EISSHLRARNPDFP----- -----------------DVTTGVYVHKVTPDSPSD---IAGVQNGDVIIKINGK----QINGVSDVLETLKQN-QVLNAS IC-RRGRTIVVRIIAEEIVH------------------------------------------------------------ -------------------------------------------------------------------------- >Homo_sapiens_HTRA2 --------------------------------------------------------------------------MAAPRA GRGAGWSLRA-WRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGV----TEPRACLTSGTPGP-- ---------RAQLTAVTPDTRTREASENSGTRS----------------------------------------------- ----RAWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAA----VPSPPPAS-PRSQYN-FIADVVEKTAPAVVYIEILDR- --HPFLG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLLSGDT-----------------YEA VVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA-------- ---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSSSG-ISG--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SQRRYIGVMMLTLSP----------------------SILAELQLREPSFP----- -----------------DVQHGVLIHKVILGSPAH---RAGLRPGDVILAIGEQ----MVQNAEDVYEAVRTQ-SQLAVQ IR-RGRETLTLYVTPEVTE------------------------------------------------------------- -------------------------------------------------------------------------- >Gorilla_gorilla_HTRA2 --------------------------------------------------------------------------MAAPRA GRGAGWSLRA-WRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVRV----TEPRACLTSGTPGP-- ---------RAQLTAVTPDTRTQEASENSGTRS----------------------------------------------- ----RAWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAA----VPGPPPAS-PRSQYN-FIADVVEKTAPAVVYIEILDR- --HPFLG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLLSGDT-----------------YEA VVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA-------- ---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSSSG-ISG--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SQRRYIGVMMLTLSP----------------------SILAELQLREPSFP----- -----------------DVQHGVLIHKVILGSPAH---RAGLRPGDVILAIGEQ----MVQNAEDVYEAVRTQ-SQLAVQ IR-RGRETLTLYVTPEVTE------------------------------------------------------------- -------------------------------------------------------------------------- >Macaca_mulatta_HTRA2 --------------------------------------------------------------------------MAAPRA GRGAGWSLRA-WRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLCVGV----PEPRACLTSGTPGP-- ---------RAQLTAVTPDTRTREASENSGTRS----------------------------------------------- ----RAWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAA----VPGPPPAS-PRSQYN-FIADVVEKTAPAVVYIEILDR- --HPFLG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLLSGDT-----------------YEA VVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA-------- ---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSSSG-ISG--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SQRRYIGVMMLTLSP----------------------SILAELQLREPSFP----- -----------------DVQHGVLIHKVILGSPAH---RAGLRPGDVILAIGGQ----MVQNAEDVYEAVRTQ-SQLAVQ IR-RGRETLTLYVTPEVTE------------------------------------------------------------- -------------------------------------------------------------------------- >Mus_musculus_HTRA2 --------------------------------------------------------------------------MAALKA GRGANWSLRA-WRALGGIFWRKPPLLAPDLRALLTSGTPDSQIWMTYGTPSLPAQVPEGF----LASRADLTSRTPDL-- ---------WARLNVGTSGSSDQEARRSPGSRR----------------------------------------------- ----REWLAV-AVGAGGA-VVLLLWG-WGRGLSTVLAA----VPAPPPTS-PRSQYN-FIADVVEKTAPAVVYIEILDR- --HPFSG-REVPISNGSG----FVVA-SDGLIVTNAHVV------ADRRRVRVRLPSGDT-----------------YEA MVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA-------- ---LQNTITSGI-----VSSAQRPARDLGLPQN--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSWFG-TSG--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SQRRYIGVMMLTLTP----------------------SILIELQLREPSFP----- -----------------DVQHGVLIHKVILGSPAH---RAGLRPGDVILAIGEK----LAQNAEDVYEAVRTQ-SQLAVR IR-RGSETLTLYVTPEVTE------------------------------------------------------------- -------------------------------------------------------------------------- >Rattus_norvegicus_HTRA2 --------------------------------------------------------------------------MAALKA GRGANWSLRA-WRALGGIFWRKGPLLAPDLRALLTSGTPDPQARMTYGTPSLPARVPLGV----LASRANLTSGTPDL-- ---------WVRLTVGTPGSSDQEDCGSPGSRR----------------------------------------------- ----REWLAV-ALGAGGA-VLLLLWG-WGRGPSTVLAA----VPAPPPTS-PRSQYN-FIADVVEKTAPAVVYIEILDR- --HPFSG-REVPISNGSG----FIVA-SDGLIVTNAHVV------ADRRRVRVRLPSGDT-----------------YEA MVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA-------- ---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSWFG-ISG--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SQRRYIGVMMLTLTP----------------------SILAELQLREPSFP----- -----------------DVQHGVLIHKVILGSPAH---RAGLRPADVILAIGEK----MIQNAEDVYEAVRTQ-SQLAVR IR-RGPETLTLYVTPEVTE------------------------------------------------------------- -------------------------------------------------------------------------- >Oryctolagus_cuniculus_HTRA2 --------------------------------------------------------------------------MAALRA GRGAGWSLWG-LRALGGIRWGKGPLLTSDLRALLTSGTPDLRARMTYGTPSLRARLAVGV----PEPRAFLTSGSPDP-- ---------RPRLTAGAPDSRPREASGTPGTRP----------------------------------------------- ----RVWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAS----VPAPPPTS-PRSQYN-FIADVVEKTAPAVVYIEILDR- --HPFSG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLPSGDT-----------------YEA MVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA-------- ---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSWFG-ISG--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SQRRYIGVMMLTLTP----------------------SILAELQLREPSFP----- -----------------DVQHGVLIHKVILGSPAH---RAGLRPGDVILAIGEQ----LVQNAEDVYEAVRTQ-SQLAVR IR-RGSETLTLYVTPEVTE------------------------------------------------------------- -------------------------------------------------------------------------- >Canis_familiaris_HTRA2 --------------------------------------------------------------------------MAALRA GRGAAWNLRG-WRALGGVHSGKGPLLTPDLRALLTSGIPDPRARVTYGTPSLRARWSVGV----PEPRTCLTSRTSDS-- ---------RAWLAVGTPDPRTQEGSGTPGTRP----------------------------------------------- ----RIWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAS----VLGSPPSS-PRSQYN-FIADVVEKTAPAVVYIEILGR- --HPFSG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLLSGDT-----------------YEA VVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA-------- ---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSWFG-ISG--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SQRRYIGVMMLTLTP----------------------SILAELQLREPSFP----- -----------------DVQHGVLIHKVILDSPAH---RAGLRPGDVILAIGEQ----LVQNAEDIYEAVRTQ-SQLAVR IR-RGPETLTLYVTPEVTE------------------------------------------------------------- -------------------------------------------------------------------------- >Felis_catus_HTRA2 --------------------------------------------------------------------------MAALRA GRGAGWNLWG-WRALGGVPWGKGPLLTPDLRALLTSGTPDPRARVTYGTPSLWARLSGGV----PEPRTCLTSGTSDS-- ---------RARLTAGSPDLKTREVSETPGTRP----------------------------------------------- ----RIWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAS----VLGSPPTS-PRSQYN-FIADVVEKTAPAVVYIEILGR- --HPFSG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLLSGDT-----------------YEA MVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA-------- ---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSWFG-ISG--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SQRRYIGVMMLTLTP----------------------SILAELQLREPSFP----- -----------------DVQHGVLIHKVILDSPAH---RAGLRPGDVILAIGEQ----LVQNAEDIYEAVRTQ-SQLAVR IR-RGPETLTLYVTPEVTE------------------------------------------------------------- -------------------------------------------------------------------------- >Bos_taurus_HTRA2 --------------------------------------------------------------------------MAALRA GRGAGWSLRG-WRALWGGRWGKGPLLTPDLRALLTSGTPDPRTRVTYGTPSFRARLSVGV----PEPRTCLRSRTSDL-- ---------RARLIAGTPDPRTPEDSGTPGTRL----------------------------------------------- ----RVWLAV-ALGAGGA-VLLLFWG-GGRGPPAVLAS----VLGSPPTS-PRSQYN-FIADVVEKTAPAVVYIEILGR- --HPFSG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLPSGDT-----------------YEA VVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA-------- ---LQNTITSGI-----VSSAQRPAKDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT MKVT----SGISFAIP-------------------------SDRLREFLHRGEK-KNSWFG-ISG--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SQRRYIGVMMLTLTP----------------------SILAELQLREPSFP----- -----------------DVQHGVLIHKVILDSPAH---RAGLRPGDVILAIGEQ----LVQNAEDIYEAVRTQ-SQLAVR IR-RGQETLTLYVTPEVTE------------------------------------------------------------- -------------------------------------------------------------------------- >Equus_caballus_HTRA2 --------------------------------------------------------------------------MAALRA GQGAGWSLRG-WRALGGVRWGKGPLLTPDLRALLTSGTSDPRARVTHGTPSLQARLSGGV----PEQRTCLTSGTSDS-- ---------RAQLTGGNPDPRTREDSGTPGTRP----------------------------------------------- ----RVWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAS----VLGSPPTS-PRSQYN-FIADVVEKTAPAVVYIEILGR- --HPFSG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLPSGDT-----------------YEA VVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA-------- ---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSSLG-ISG--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SQRRYIGVMMLTLTP----------------------SILAELQLREPSFP----- -----------------DVQHGVLIHKVILDSPAH---RAGLRPGDVILAIGEQ----LVQNAEDIYEAVRTQ-SQLAVR IR-RGPETLTLYVTPEVTE------------------------------------------------------------- -------------------------------------------------------------------------- >Anolis_carolinensis_HTRA2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------SPPPPR----------------------------------------------- ----WRWAAMGACGAGAGLLLLLFFP---RKPAEARPP----VPSPPPSP--RSTYN-FIADVVERTAPALVYIEILGR- --HPFSG-REVPISNGSG----FVVS-SDGLIVTNAHVV------ANRRRVRVRLASGEL-----------------YDA TVRLVDQVADIATLK--------------ISPK---KP--LPTLRLGRSSEVR------QGEFVVAMGSPFA-------- ---LQNTITSGI-----VSSAQRGGRELGLSSS--------DIEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT MKVT----PGISFAIP-------------------------SDRLRAFLEKEEKSKDSWFGGKKE--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------GKRRYIGVMMLTLTS----------------------SILSELKMRDPSFP----- -----------------DISYGVLIHKVIIGSPAH---QAGLKAGDVVVEINGR----ASRRAEDVYEAVRTQ-DHLTLL VH-RGYEALLLTITPEVTE------------------------------------------------------------- -------------------------------------------------------------------------- >Danio_rerio_HTRA2a -----------------------------------------------------------------------------MAT SHVNRCLLRTITRCHRDSSRQLN-LTTVRALGHFSNFSSGKEEHVETVDPPRGSGGGSGT----SRLAVALGLGLGGA-- -----------AAVFSLRGEDNKDALQRTVAVK----------------------------------------------- ----NLLIDS---------------------ILPTVQC----ASPFKPDS-PRYKYN-FIADVVEKSTPAVVYIEIVGR- --HPFSG-REVPISNGSG----FIVS-SDGLIVTNAHVV------ANKRGVRVKLTNGET-----------------YNA TVQDVDQAADIATIK--------------INVK---NP--LPTLRLGKSSDVR------QGEFVVAMGSPFS-------- ---LKNTITSGI-----VSSAQRGSKELGLSNS--------NMDYIQTDATID--FGNSGGPLINLDG-----EVIGINT MKVT----AGISFAIP-------------------------SDRVRLFLDRSADKQNSWFG-ESGWKRRYIGVMMLTLTP RHPFSGREVPISNGSGFIISSDGLIVTNGHVVANKCGVRVKLTNDETYNATVQDVDQAADIASIKINVKNPLPTLRLGKS SDVRQGEFVVAMGSPFSLKNTITSGIVSSAQRGSKELGLSNSNMDYIQTDATIDFGNSGGPLINLDGEVIGINTMKVTAG ISFAIPLFLDRSADKQKSWFGESESKRRYIGVMMLTLTP----------------------SIIKELRMRDPSFP----- -----------------DVSHGVLIHRVIVGSPAN---RAGMKPGDVIIEINGV----KVNTSEEIYNAVRTS-ESLNVV VR-RGADLLMLHMTPESTE------------------------------------------------------------- -------------------------------------------------------------------------- >Danio_rerio_HTRA2b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------------LFR- --HPFSG-REVPISNGSG----FIIS-SDGLIVTNAHAV------ANKRGVRVKLTNGET-----------------YNA TVQDVDQAADIATIK--------------INVK---NP--LPTLRLGKSSDVR------QGEFVVAMGSPFS-------- ---LKNTITSGI-----VSSAQRGSKELGLSNS--------NMDYIQTDATID--FGNSGGPLIHLDG-----EVISINT MKVT----AGISFAIP-------------------------SDRVRLFLDRSADKQNSWFG-ESG--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------SKRRYIGVMMLTLTP----------------------SIIDELRMRDPSFP----- -----------------DVSHGVLIHRVIVGSPAN---RAGMKPGDVIIEINGV----KVNTSEEIYNAVRTS-ESLNVV VR-RGADLLMLHMTPESTER------------------------------------------------------------ -------------------------------------------------------------------------- >Takifugu_rubripes_HTRA2a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------PDS-PRYKYN-FIADVVEKSTPAVVYIEILGR- --HPFSG-REVTVSNGSG----FLIS-TDGLIVTNAHVV------ANKRGVRVKLNNGEM-----------------YNA TVQDVDQVADIATIK--------------ISVK---NP--LPTLPLGCSAQVR------QGEFVVAMGSPFA-------- ---LRNTITSGI-----VSSAQRGSKELGLSNT--------NMDYIQTDAAID--FGNSGGPLINLDG-----EVIGINT MKVT----AGISFAIP-------------------------SDRLRLFLDRAEQKKSSWFR-DSD--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------TRRRYIGVMMLTLTP----------------------SIIAELKLRDPSFP----- -----------------EVTHGVLIHRVIMGSPAN---RAGMIPGDIVVEINGA----KANTSEEVYEAVRSS-DHISML VQ-RGGELLQLRVTPEYTE------------------------------------------------------------- -------------------------------------------------------------------------- >Takifugu_rubripes_HTRA1b ---------------------------------------------------------------MRLWVVLCATVLLA--- --AEARIVKRLAIG-CPDKCDKSQCAPVPA-DCLAGDVLDRCDCCPVCGAGDGEQCGGTD---DRECAEGLECLVTD--- GVEVSATVRRRGTAGMCVCTS---SQPVCGSDG----------------------------------------------- ----VSYRNICELKRVSNMAVKMQRPPVIFIQRGACG------EGQQNPDSLRYKYN-FIADVVEKIGPAVVHIELYRK- --MMFTK-RELAVASGSG----FVVS-EDGLIVTNAHVV------ANKHRVKVELKSGAT-----------------FDA KVRDIDEKADIALIK--------------IDAPTK-----LPVLLLGRSADLR------PGEFVVAIGSPFS-------- ---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDKIRQFLAESHDRQSESNGRFQHFHPFPSS-------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------GQTTTQKKFIGIRMLSITP----------------------TLAKELKEKQPDFP----- -----------------DVTSGVYVIEVISRTPAA---RAGLQDKDVIISINGE----QISSSSDVSEIIKTG-SVLRTV VR-RGNEDVILTIIPEEMEP------------------------------------------------------------ -------------------------------------------------------------------------- >Gasterosteus_aculeatus_HTRA2a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------PDS-PRFKYN-FIADVVEKSTPAVVYIEIVGR- --HPFSG-REVPVSNGSG----FIIS-SDGLIVTNAHVV------ANKKGVRVKLTNGET-----------------YNA TVKDVDPVADIATIK--------------ISAK---SP--LPTLALGRSSDVR------QGEFVVAMGSPFS-------- ---LRNTITSGI-----VSSVQRGSKELGLSNS--------NMDYIQTDAAID--FGNSGGPLINLDG-----EVIGINT MKVT----PGISFAIP-------------------------SDRLTLFLDQAAKKKNSRSG-ESA--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------TKRRYIGVMMLTLTP----------------------SIISELKLRDRSFP----- -----------------DVAYGILIHRVILGSPAD---RAGMLPGDVVVEINGV----KVNTSEEIYQAVRSG-DKITTV VQ-RGHQLLRLQITPESTEP------------------------------------------------------------ -------------------------------------------------------------------------- >Oryzias_latipes_HTRA2a -------------------------------------------------------------------------MAVSAAV RKCFVSALVTQARCQRLNALPKNTFSRASSAVTCGHGEPTGRKSLYDRAEAEGDSGQSGG----SVLWTSLGLGLCGA-- -----------AFL-----DSQKDKGVRGDSKS----------------------------------------------- ----RRFLEL---------------------LLPSAHC----ASPFKPDS-PRFKYN-FIADVVEKSTPAVVYIEILGR- --HPFSG-REVPVSNGSG----FIIS-SDGLIVTNAHVV------ANKRGVRVKLTNGDM-----------------YHA SVQDVDPVADIATIK--------------ITTKDVQNP--LP-IETGQSSDIR------QGEFVVAMGSPFA-------- ---LRNTITSGI-----VSSAQRDSKELGLSNP--------NMEYIQTDATID--FGNSGGPLINLDG-----EVIGINT MKVT----AGISFAIP-------------------------SDRLKIFLDQAAKKTKSSVG-ESR--------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------TKARYIGVMMLTLTP----------------------SIITELQLRDPMFP----- -----------------NVTHGILIHRVIIGSPAS---RAGMLAGDIVVEINGV----KVNTSEEIYKAVRSS-DRITML VQ-RGKELLRLQVTPEFIDP------------------------------------------------------------ -------------------------------------------------------------------------- >Branchiostoma_floridae_HTRA2 ---------------------------------------------------------------------MTRTGFYLR-- ----------------------TCSTS--VGNNTSKGYK--YLRDSGIVVGCFAWGYVIG---------KFG-------- -------------------------------VP----------------------------------------------- ----YIWPSTDSADKEKSS--IVKKVDAAEPFYGGEGYG---------GIPRSKQFN-FIADVVEIASPAVVYIEIQGKN --PFTGG-RA-PTSNGSG----FIVR-EDGLVVTNAHVVAN--KRY----VKVRLQDGRL-----------------LDG VVTLVDQAADIAAVKI-------------INCNTP-----LKTVKLGNSSTLR------PGEWVVAMGSPLS-------- ---LSNTITAGV-----ISSVQRGSRELG-----LR-H--NDMDYIQTDAAIN--FGNSGGPLVNLDG-----EVIGVNT MKVT----TGISFAIP-------------------------IDKVKEFLKNVEEKEKAQKG-WFGR-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------GQVAPPSPPKRRYLGVTMVTLTP----------------------NIIMELQERRTDFP----- -----------------DVRTGVLVHRIIVGSPAY---SAGIRPGDVITSINGR----QVTSARDIYDAVNS-GQQLNIT CH-RGRTVHHLQVTPEEAD------------------------------------------------------------- -------------------------------------------------------------------------- >Drosophila_melanogaster_HTRA2 --------------------------------------------------------------------MALRGSHRLEVI FKRCIASPVLHSHAANRRSSQLAIKEGDPNSNGNSGQYQQNGEQKEKGWRRLVRFFVPFS-------------------- ------------------------------LGA----------------------------------------------- ----VVSAAIIQREDLT--------PTIAA--SKMTG--------------RRRDFN-FIADVVAGCADSVVYIEIKDTR HFDYFSG-QPITASNGSG----FIIE-QNGLILTNAHVVIN--KPHT--MVQVRLSDGRT-----------------FPA TIEDVDQTSDLATLR--------------IQVNN------LSVMRLGKSSTLR------SGEWVVALGSPLA-------- ---LSNTVTAGV-----ISSTQRASQELG-----LR-N--RDINYLQTDAAIT--FGNSGGPLVNLDG-----EAIGVNS MKVT----AGISFAIP-------------------------IDYVKVFLERAAEKR--KKGSAYKT-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------GYP-VKRYMGITMLTLTP----------------------DILFELKSRSQNMPS---- -----------------NLTHGVLVWKVIVGSPAH---SGGLQPGDIVTHINKK----EIKNSSDVYDALADNSKTLDIV IL-RGVKQMHVTITPEDP-------------------------------------------------------------- -------------------------------------------------------------------------- >Apis_mellifera_HTRA2 ----------------------------------------------------------------------------MAAP LTRTSWTVLRRNHFQYKQFLTVSCVNR-FSQYKYSHQQDKKFRTSEKTVRNVLFYTIFFS-------------------- ------------------------------GFG----------------------------------------------- ----YVLYKWKDDCQNRFSNLIKSMFTIYAKPVSWDGG------------NNRNKYN-FIADVVEKSAPAVVYIEIQNNR RFDFQTG-KPFNISNGSG----FIVE-SDGLILTNAHVVTA--KPHT--TVKVRLYDGSV-----------------YTG TVEDIDVHSDLATVR--------------INKTN------LPVMKLGSSSNLR------PGEFVVAIGSPLA-------- ---LSNTITSGV-----ISSVNRHSQELG-----LL-N--KQMAYIQTDAAIT--FGNSGGPLVNLDA-----EAIGINA MKVT----SGISFAIP-------------------------IDYAKDFLRKAELRR-KNKGTQFAM-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------EKT-KTQYIGITMLTLTP----------------------DLFYELQKKLKGIPH---- -----------------NIRYGVLVYKVIVGSPAH---LGGLQAGDIITQVNDE----PVVSSASIYKAIEA-AKILRMT VI-RGLEVLHLRIEPEEI-------------------------------------------------------------- -------------------------------------------------------------------------- >Anopheles_gambiae_HTRA2 ------------------------------------------------------------------MHCALR---RPALF LQRRLLAVVQLAPHNNLRAFGGTGEHG--RSDG-SGEHSDSWSAQKAGLTATLALAGMFG-------------------- ------------------------------LLA----------------------------------------------- ----YNTRPDQSKRKATGWPAFGFLPTVSAKTSATAG--------------NRQQYN-FIADAVEISAPAVVFIEIRDRQ RVDFFTR-EPVTVSNGSG----FIIE-RDGLILTNAHVVVS--KPHT--LVTVRLTDGRT-----------------FPG QVEHVDPTSDLATVR--------------IRCDN------LPTLRLGSSADLR------PGEWVVALGSPLA-------- ---LNNTVTAGV-----VSSTQRASQELG-----LR-G--KDINYIQTDAAIT--FGNSGGPLVNLDG-----EAIGINS MKVT----SGISFAIP-------------------------IDHAKAFLRKIHETAGTAGGRRLSS-------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------GAPSYRRYIGITMLSLTP----------------------DILHELQQRNHNFPP---- -----------------TVRGGVLVWKVIQGSPAH---SGGLQPGDIITHINGK----EINSSGDVYELLAAQEKKLAIT IY-RGQQPATVHVFPEDTTA------------------------------------------------------------ -------------------------------------------------------------------------- >Homo_sapiens_HTRA3 -----------------------------------------------------------------------MQARALLLA ALAALALAREPPAAPCPARCDVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGGPL---DSPCGESLEC------- ------------VRGLCRCRW---SHAVCGTDG----------------------------------------------- ----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------LGLHQLSSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-EAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDS-----------------YEA TIKDIDKKSDIATIK--------------IHPKKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA-------- ---LQNTVTTGI-----VSTAQREGRELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDRITRFLTEFQDKQIKD--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------WKKRFIGIRMRTITP----------------------SLVDELKASNPDFP----- -----------------EVSSGIYVQEVAPNSPSQ---RGGIQDGDIIVKVNGR----PLVDSSELQEAVLTE-SPLLLE VR-RGNDDLLFSIAPEVVM------------------------------------------------------------- -------------------------------------------------------------------------- >Pan_troglodytes_HTRA3 -----------------------------------------------------------------------MQARALLLA ALAALALAREPPAAPCPARCDVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGGPL---DSPCGESLEC------- ------------VRGLCRCRG---SHAVCGTDG----------------------------------------------- ----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------LGLHQLSSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-EAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDS-----------------YEA TIKDIDKKSDIATIK--------------IHPK----------------------------------------------- -------------------------------------------------------YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDRITRFLTEFQDKQIKD--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------WKKRFIGIRMRTITP----------------------SLVDELKASNPDFP----- -----------------EVSSGIYVQEVAPNSPSQ--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------- >Gorilla_gorilla_HTRA3 -----------------------------------------------------------------------MPARALLLA ALAALALAREPPAAPCPARCDVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGGPL---DSPCGESLEC------- ------------VRGLCRCRW---SHAVCGTDG----------------------------------------------- ----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------LGLHQLSSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-EAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDS-----------------YEA TIKDIDKKSDIATIK--------------IHPKKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA-------- ---LQNTVTTGI-----VSTAQREGRELGLQDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDRITRFLTEFQDKQIKDL-------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------ANWKKRFIGIRMRTITP----------------------SLVDELKASNPDFP----- -----------------EVSSGIYVQEVAPNSPSQ---RGGIQDGDIIVKVNGR----PLVDSSELQEAVLTE-SPLLLE VR-RGNDDLLFSIAPEVVMDP----------------------------------------------------------- -------------------------------------------------------------------------- >Pongo_abelii_HTRA3 ------------------------------------------------------------------------------LA QPLPARVTEEPPAAPASLAWSVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGGPL---DSPCGESLEC------- ------------VRGLCRCRW---SHAVCGTDG----------------------------------------------- ----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------LGLHQLSSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-EAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDS-----------------YEA TIKDIDKKSDIATIK--------------IHPKKK---P-TLCCCVGHSADLR------PGEFWWAIGSPFA-------- ---LQNTVTTGI-----VSTAQRGGQGAGPPGT---P----TWDYIHCFLPLQ--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDRITRFLTEFQDKQTKD--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------WKKRFIGIRMRTITP----------------------SLVDELKASNPDFP----- -----------------EVSSGIYVQEVAPNSPSQ---RGGIQDGDIIVKVNGR----PLVDSSELQEAVLTE-SPLLLE VR-RGNDDLLFSIAPEVVM------------------------------------------------------------- -------------------------------------------------------------------------- >Macaca_mulatta_HTRA3 -------------------------------------------------------------------------------- ------------------------------------------------------XCGSPL---DSPCGESLEC------- ------------VRGLCRCRW---THAVCGTDG----------------------------------------------- ----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------LGLRQLSSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-EAGLIITNAHVVSSNNAASGRQQLKVQLQNGDS-----------------YEA TIKDIDKKSDIATIK--------------IHPKKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA-------- ---LQNTVTTGI-----VSTAQREGRELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDRITRFLTEFQDKQIKD--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------WKKRFIGIRMRTITP----------------------SLVDELKASNPDFP----- -----------------EVSSGIYVQEVTPNSPSQ---RGGIQDGDIIVKVNGR----PLVDSSELQEAVLTE-SPLLLE VR-RGNDDLLFSIAPEVVM------------------------------------------------------------- -------------------------------------------------------------------------- >Callithrix_jacchus_HTRA3 -----------------------------------------------------------SPTPPPAAGPAAMQARALFLA ALVALALAREPPAAPCPARCDVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGGPL---DSPCGESLEC------- ------------VRGLCRCRW---THAVCGTDG----------------------------------------------- ----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------LGLHQLSSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-EAGLIVTNAHVVTSRNTASGRQQLKVQLQNGDS-----------------YEA TIKDIDKKSDIATIK--------------IHPKKK-----LPVLLLGQSADLR------PGEFVVAIGSPFA-------- ---LQNTVTTGI-----VSTAQREGRELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDRITRFLTEFQDKHIKGKE------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------LTYWKKRFIGIRMRTITP----------------------SLVDELKASNPDFP----- -----------------GVSRGIYVQEVAPNSPSQ---RGGIQDGDIIVKVNGR----PLVDSSELQEAILNE-SPLLLE VR-RGNDDLLFSIAPEVVIGP----------------------------------------------------------- -------------------------------------------------------------------------- >Mus_musculus_HTRA3 -----------------------------------------------------------------MQARALLPATLAILA TLAVLALAREPPAAPCPARCDVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGRPL---DSPCGDSLEC------- ------------VRGVCRCRW---THTVCGTDG----------------------------------------------- ----HTYADVCALQAASRRALQVSGTPVRQLQKGACP------SGLHQLTSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-EAGLIVTNAHVVSSSSTASGRQQLKVQLQNGDA-----------------YEA TIQDIDKKSDIATIV--------------IHPKKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA-------- ---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVA----AGISFAIP-------------------------SDRITRFLSEFQNKHVKD--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------WKKRFIGIRMRTITP----------------------SLVEELKAANPDFP----- -----------------AVSSGIYVQEVVPNSPSQ---RGGIQDGDIIVKVNGR----PLADSSELQEAVLNE-SSLLLE VR-RGNDDLLFSIIPEVVM------------------------------------------------------------- -------------------------------------------------------------------------- >Rattus_norvegicus_HTRA3 -----------------------------------------------------------------MQARALLPATLATLA TLAVSVLAREPPAAPCPARCDVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGRPL---DSPCGDSLEC------- ------------VRGVCRCRW---THTVCGTDG----------------------------------------------- ----HTYADVCALQAASRRALQISGTPVRQLQKGACP------SGLHQLTSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-EAGLIVTNAHVVSSSNTASGRQQLKVQLQNGDA-----------------YEA TIQDIDKKSDIATIL--------------IHPNKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA-------- ---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVA----AGISFAIP-------------------------SDRITRFLSEFQDKHVKD--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------WKKRFIGIRMRTITP----------------------SLVEELKTANPDFP----- -----------------AVSSGIYVQEVVPNSPSQ---RGGIQDGDIIVKVNGR----PLVDSSELQEAVLNE-SSLLLE VR-RGNDDLLFSIMPEVVM------------------------------------------------------------- -------------------------------------------------------------------------- >Canis_familiaris_HTRA3 -------------------------------------------------------------------------------- ---------------------------------------------------------RLL---VSPCEKSVEC------- ------------ARGVFRCGW---AHPVCGTDG----------------------------------------------- ----HTYANVCALQAASRRALELSGTPVRQLQKGACP------SGLHQLTSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-EAGLIVTNAHVVSSTNAVSGRQQLKVQLQNGDT-----------------YEA TIKDIDKKSDIATIK--------------IHPKKK-----LPALLLGRSADLR------PGEFVVAIGSPFA-------- ---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVA----AGISFAIP-------------------------SDRITRFLTEFQDKHVKD--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------WKKRFIGIRMRTITP----------------------SLVEELKASNPDFP----- -----------------SVSSGIYVQEVVPNSPSQ---RGGIQDGDIIVKVNGR----PLADSSELQEAVLTE-SPLLLE VR-RGNDDILFSISPEVVL------------------------------------------------------------- -------------------------------------------------------------------------- >Felis_catus_HTRA3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------QAASRRALQLSGTPVRQLQKGACP------SGLHQLTSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-EAGLIVTNAHVVSTSNAVSGRQQLKVQLQNGDT-----------------YEA TIKDIDKKSDIATIQ--------------IHPKKK-----LPALLLGHSADLR------PGEFVVAIGSPFA-------- ---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYVQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVA----AGISFAIP-------------------------SDRITRFLTEFQDRHAKD--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------WKKRFIGIRMRTITP----------------------SLLEELKASDPDFP----- -----------------SVSSGIYVQEVVPNSPSQS--RGGIQDGDIIVKVNGR----PLADSSELQEAVLTE-SPLLLE VR-RGNDDLLFSIAPEVVL------------------------------------------------------------- -------------------------------------------------------------------------- >Equus_caballus_HTRA3 ------------------------------------------------------------------------------LA GLAALALATELPAAPCPASCDVSRCPSS---RCPGGYVPDLCNCCLVCAAGEGEPCGRPL---DSPCGESLEC------- ------------ARGVCRCRW---AHAVCGTDG----------------------------------------------- ----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------SGLHHLTSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-EAGLIVTNAHVVSSTNSVSGRQQLKVQLQNGDT-----------------YEA TIQDIDKKSDIATIK--------------IHPKKK-----LPALLLGHSGDLR------PGEFVVAIGSPFA-------- ---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVA----AGISFAIP-------------------------SDRITRFLTEFQDKHIKD--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------WKKRFIGIRMRTITP----------------------SLLEELKASNPDLP----- -----------------TVSSGIYVQEVVPNSPSQ---RGGIQDGDIIVKVNGR----PLADSSELQEAVLNE-SPLLLE VR-RGNDDLLFSIAPEVVV------------------------------------------------------------- -------------------------------------------------------------------------- >Gallus_gallus_HTRA3 ---------------------------------------------------------------MRLSLLSPLLLLCLSR- --SRGSAELPAARAKCPTRCDVSKCPSP---SCPSGYVPDRCNCCLICAAGEGDSCGRKE---DPPCGDSLDCRYPMG-- ---------KRFAKGVCQCKL---SVQVCGSDG----------------------------------------------- ----RTYDNICQLKAVSRKALQHGLPAVAQVQKGACES------GHLQSSSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-DSGLIVTNAHVVSSTNAISGRQQLKVQLQNGDT-----------------YEA TIRDIDKKSDIATIK--------------IHPKKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA-------- ---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDRITQFLTESLDKQNK---------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------DSKKRFIGIRMLTITP----------------------ALVEELKHNNADFP----- -----------------DVRSGIYVHEVVPNSPSH---RGGIQDGDIIVKVNGR----PLMTSSDLQEAVMNE-SPLLLE VR-RGNDDLLFNIEPEIVM------------------------------------------------------------- -------------------------------------------------------------------------- >Taeniopygia_guttata_HTRA3 -------------------------------------------------------------------------------- -------------AKCPARCDVSTCPSP---SCPSGYVPDRCGCCLICAAGEGDSCGRKE---DPPCGDSLDCRYPMG-- ---------KRFAKGVCQCKL---SAQVCGSDG----------------------------------------------- ----RTYDNICQLKAVSRKALQHGLPAVAQVQKGACES------GRSMSSSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIMS-DSGLIVTNAHVVSSTNAISGRQQLKVQLQNGDT-----------------YEA TIKDIDKKSDIATIK--------------IHPKKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA-------- ---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDRITQFLTESHDKQSKG--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------KTDGKKRFIGIRMLTITP----------------------ALVEELKHSNADFP----- -----------------DVRSGIYVHEVVPNSPSH---RGGIQDGDIIVKVNGR----PLLTSSDLQEAVMNE-SPLLLE VR-RGNDDLLFNIEPE---------------------------------------------------------------- -------------------------------------------------------------------------- >Anolis_carolinensis_HTRA3 -------------------------------------------------------------------------------- ----------PAGDRCPARCDVSRCPSS---ICPSGYVPDGCNCCLVCAAGEGEACGRAE---DPPCGEGLQCRSFNA-- ---------EPERRGVCQCKL---GAAVCGSDG----------------------------------------------- ----RSYANACRLQTAARQALQQGRPPVRQVQKGACRAA---STGHQQLNSPRFKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-HNVPLSSGSG----FIMS-DTGLIVTNAHVVSSSSTVTGRQQLKVQLQDGDT-----------------YEA KIKDIDKKSDIATIK--------------INPRKK-----LPALSIGQSGDLR------PGEFVVAMGSPFA-------- ---LQNTVTTGI-----VSTAQRDGKELGLKDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVT----AGISFAIP-------------------------SDRIAQFLSENYDKKGNS--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------KIDGKKRFIGIRMLTITP----------------------VLMEELKVNNPDFP----- -----------------DVISGIYVHEVVPNSPSQ---RGGIEDGDIIVKVNGR----PLKTSADLQDAVMNE-SPLLLE VR-RGNDDLLFNIEPEVVIP------------------------------------------------------------ -------------------------------------------------------------------------- >Xenopus_tropicalis_HTRA3 --------------------------------------------------------ETPQLSELPISLLLRMKLCAWLPL CALLTLLSGATRTGACPARCDVSRCPSP---ICPSGYVPDRCNCCLICAAGEGEPCGREG---DPPCGDSLQCKPPPG-- ---------MRGLKGSCQCKH---TNPVCANDG----------------------------------------------- ----QTYDNLCQLKAASRRALQKGHSPVVLVQKGACQSA---SIGHQHPNSPRYKFN-FIADVVEKIAPAVVHIELFLR- --HPLFG-RNVPLSSGSG----FIIS-DLGLIVTNAHVVSSSNTVSGRQYLKVQLHNGDS-----------------YEA TIKDIDKKSDIATIK--------------IYPRKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA-------- ---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYVQTDAIIN--YGNSGGPLVNLDG-----EVIGINT LKVA----AGISFAIP-------------------------SDRITKFMTESQDKKYKA--------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------NNDGKKRFIGIKMLTITP------------------