>Homo_sapiens_GRK4 ---------------------------------------------MELENI-VANSLLLKARQ----------------- ----------------GGYGKKSGRSKKWKEILTLPPVSQCSELRH-SIEKDYSSLCDKQPIG---------RRLFRQFC D-TKPTLKRHIEFLDAVAEY--EVADDE--DRSDCGLSILDRFFND---------------------------------- -------------------------------------------------------------------------------- ---------KLAAPLPEIPPDVVTECRLG----LKEENPSKKAFEECTR-----------------------------VA HNYLRGEPFEEYQES-------------------SYFSQFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRHYRVLGKGGFGEVCA-------------CQVRATGKM YACKK-LQKK-RIKKRKGEAMALNEKRILEKVQ--SRFVVSL--AYAYETKDALCLVLTIMNGG-DLK-----------F HIYNLGNP------GFDEQRAVFYAAELCCGLE-DLQRER-IVYR---DLKP--ENILLDDRG--HIRISDLGLATEIP- ------EGQRVRGRVGTVG-YMAP--EVVNNE-KYTFSPDWWG---LGCLIYEMIQGHSPFK----KYKEKVKWEEVDQR IKNDTEEYS-EKFSEDAKSICRMLLTK-NPSKRLGCRG-----EGAAGVKQHPVFKD---------INFRRLEA------ --------NML---EPPFCP-----DPHA--VYCKDVLDIEQFSVVK--GIYLDTADEDFYARFATGCVSIPWQN----- -----------EMIESGCFKDIN-KSESEEALPLDLDKNIHTPVS----------------------------------- -------------------------------------------------------RPNRGFFY-RLFRRG---------- GCLTMVPSEKEVEPKQC--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Mus_musculus_GRK4 ----------------------------------------------MELENFVANNLLLKARL----------------- -----------------GFNKQTGRSKKWRELLKFPPVSMCTELRW-SIEKDFSSLCDKQPIG---------RLLFRQFC D-TKPDLKRCIEFLDAVAEY--EVTIEE--EQREFGLAIFSRFFKE---------------------------------- -------------------------------------------------------------------------------- ---------KSEVPLPEIPPDIVKECKWN----LKQNSPSQNVFEECAG-----------------------------IV CKYLSETPFEEYQES-------------------TYFNRFLQWKWLERRPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVCA-------------CQVRATGKM YACKK-LEKK-RIKKRKGEAMALNEKRILEKLH--SRFVVS--LAYTYETKDALCLVLTIMNGG-DLK-----------Y HIYNLGDP------GFEEPRAVFYAAELCCGLE-DLQRKR-IVYR---DLKP--ENILLDDHG--HIRISDLGLAMEVP- ------EGEMVRGRVGTVG-YMAP--EIINHE-KYTFSPDWWG---LGCLIYEMIAGHSPFR----KYKEKVNREELERR VKNETEEYS-ERFSEDAKSICSMLLIK-DPSKRLGCQR-----DGVSAVKQHPIFKD---------INFSRLEA------ --------NML---DPPFIP-----DPQA--IYCRNILDIGQFSVVK--GVNLDTNDEIFYAEFATGSVTIPWQN----- -----------EMIESGCFKDLN-ENEDD-LSSLEKYKMCSSILR----------------------------------- --------------------------------------------------------PKRNFFR-RLFRRT---------- GCLNIALSEEREPTEH---------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Rattus_norvegicus_GRK4 ----------------------------------------------MELENFMANTLLLKARQ----------------- -----------------GFTKKTGRSKKWRELLKLPPVSMCSDLRH-SIEKDFSSLCDQQPIG---------RLLFRQFC N-TKPDLKRCIEFLDAAAEY--EVTIEE--EQREFGLSIYSRFFKE---------------------------------- -------------------------------------------------------------------------------- ---------NSEVSLPQIPPDLVKECKCN----LKQSSPSQNVFQDCAG-----------------------------VI YKYLSEKPFEEYQES-------------------TYYNRFLQWKWLERRPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVCA-------------CQVRATGKM YACKK-LEKK-RIKKRKGEAMALNEKRILEKLH--SRFVVS--LAYTYETKDALCLVLTIMNGG-DLK-----------Y HIYNLGNP------GFEEQRAVFYAAELCCGLE-DLQRER-IVYR---DLKP--ENILLDDHG--HIRISDLGLALEIP- ------EGEMVRGRVGTVG-YMAP--EIISHE-KYTFSPDWWG---LGCLIYEMIAGHSPFR----KYKEKVNREEMERR VKTETEEYS-ERFSENAKSICSMLLTK-DPSKRLGCQS-----DGASAVKQHPIFKD---------INFSRLEA------ --------NML---DPPFCP-----DPEA--IYCKDILDIGQFSVVK--GVNLDTNDEIFYTQFATGCVTIPWQN----- -----------EMIESGCFKDLN-EYEDKGLSPLEKHKICSCILR----------------------------------- --------------------------------------------------------PKRNFFH-RLFRRA---------- ACLNIAHSEEREPTEH---------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Danio_rerio_GRK4 ----------------------------------------------MEIENIVANTVLLKARE----------------- ----------------GGGGKRNGRSKKWKEMLKLPHISQCEELRR-TIERDYTSLCEKQPIG---------RQLFRQFC D-TQPKLRRCIEFLDSVAMY--QVAPDE--KRRDAGLNILDTYFNN---------------------------------- -------------------------------------------------------------------------------- ---------GSAAHLPEMAQDVVGECRQK-----LEQSPCKELFQECTR-----------------------------IV REYLSGAPFSAYQET-------------------MYFSRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRHYRVLGKGGFGEVCA-------------CQVRATGKM YACKK-LEKK-RVKKRKGEAMALNEKRILEKVN--SSFVVS--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGNS------GFDEQRAIFYAAEICCGLE-DLHRER-IVY---RDLKP--ENILLDDRG--HIRISDLGLAVQIP- ------EGETIRGRVGTVG-YMAP--EVIQNE-SYTFSPDWWG---LGCLIYEMIQGQSPFR----RRKERVKREEVDRR VCEDQEEYT-EKFSEDAKDICRQLLCK-DPKERLGCRG-----SGAAEVKLHPIFRN---------INFKRLEA------ --------NML---DPPFCP-----DPRA--VYCKDVLDIEQFSTVK--GVNLDPTDDDFYHKFVTGSVSIPWQN----- -----------EMIEMECFKEIN-VFEMDGALCADLDVNRPNPAP----------------------------------- ---------------------------------------------------------KRGFFY-RLFHRE---------- VCFGSANSEEEEKEEKEEEPS----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Takifugu_rubripes_GRK4 ----------------------------------------GSRILTMEIENIVANTVLLKAREDKDQISPAPSVKVLNIC NW-KPPPPLPTQPGQHCGGGKRNGRSKKWKEMLKLPHISQCEELRR-TIERDYTSLCEKQPIG---------RLLFRQYC D-TRPELKRCIEFMDAVAMY--QLAPDE--ERRDCGLNLLDTYFNN---------------------------------- -------------------------------------------------------------------------------- ---------GSAAHLPDIPLEVVAGCRER-----LEQSPCKELFDDCTKEQRVLHLWKLSGLKARSKNSHPSAGGNHRIV RDYLSGVPFSSFQES-------------------MYFSRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRHYRVLGKGGFGEVCA-------------CQVRATGKM YACKK-LEKK-RVKKRKGEAMALNEKRILEKVN--SSFVVS--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGNS------GFDEQRAIFYAAEICCGLE-DLHRER-IVY---RDLKP--ENILLDDRG--HIRISDLGLAVQIP- ------EGETIRGRVGTVG-YMAP--EVIQNE-SYTFSPDWWG---LGCLIFEMIQGQSPFR----KRKERVKREEVDRR VREDLEEYS-DKFSEEAKDICRQLLAK-DPKERLGCQG-----RGATEVKEHPIFRN---------INFKRLEA------ --------NML---DPPFCP-----DPRA--VYCKDVLDIEQFSTVK--GVNLDPTDDDFYHKFVTGSVSIPWQN----- -----------EMIEMECFKEIN-IYETDGKLCSDLDVNRPNPPP----------------------------------- ---------------------------------------------------------KRGFFY-RLFRRE---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Tetraodon_nigroviridis_GRK4 ----------------------------------------------ADLQQIVTNNLLCLPR------------------ ----------------GGGGKRNGRSKKWKEMLKLPHISQCEELRR-TIERDYTSLCEKQPIG---------RLLFRQYC D-TRPELKRCIEFMDAVATY--QLAPDE--ERRDCGLNVLDTYFNN---------------------------------- -------------------------------------------------------------------------------- ---------GSAAHLPDIPLEVVAGCRER-----LEQSPCKELFDDCTK-----------------------------IV RDYLSGVPFSSYQES-------------------MYFSRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRHYRVLGKGGFGEVCA-------------CQVRATGKM YACKK-LEKK-RVKKRKGEAMALNEKRILEKVN--SSFVVS--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGNS------GFDEQRAIFYAAEICCGLE-DLHRER-IVY---RDLKP--ENILLDDRG--HIRISDLGLAVQIP- ------EGETIRGRVGTVG-YMAP--EVIQNE-SYTFSPDWWG---LGCLIFEMIQGQSPFR----KRKERVKREEVDRR VREDHEEYS-DKFSEEAKDICRQLLAK-DPKERLGCQG-----RGAAEVKGHPIFRN---------INFKRLEA------ --------NML---DPPFCP-----DPRA--VYCKDVLDIEQFSTVK--GVNLDPTDDDFYHKFVTGSVSIPWQN----- -----------EMIEMECFKEIN-IYETDGKLCSDLDVNRPNPPP----------------------------------- ---------------------------------------------------------KRGFFY-RLFRRE---------- VCFKSG--YSDDEIEEPSRL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Gasterosteus_aculeatus_GRK4 ----------------------------------------------MEIENIVANTVLLKARE----------------- ----------------GGGGKRNGRSKKWKEMLKLPHISQCEELRR-SIERDYTSLCEKQPIG---------RLLFRQYC D-TRPELKRCIEFMDTVAMY--QLAPDE--KRRDYGLNVLDTYFNN---------------------------------- -------------------------------------------------------------------------------- ---------GSAAHLPDVPQEMVAGCREK-----LEQSPCKELFNDCTK-----------------------------IV RDYLGGAPFSSYQES-------------------MYFSRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRHYRVLGKGGFGEVCA-------------CQVRATGKM YACKK-LEKK-RVKKRKGEAMALNEKRILEKVN--SSFVVS--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGNS------GFDEQRAIFYAAEICCGLE-DLHRER-IVYS--RDLKP--ENILLDDRG--HIRISDLGLAVQIP- ------EGETIRGRVGTVG-YMAAP-EVIQNE-SYTFSPDWWG---LGCLIFEMIQGQSPFR----KRKERVKREEVDRR VREDQEEYS-DKFVEEAKDICRQLLTK-DPKERLGCQG-----RGAIEVKQHPIFRN---------INFKRLEA------ --------NMQ---DPPFTLS----QPRA--VYCKDVLDIEQFSTVK--GVNLDPTDDDFYYKFVTGSVSIPWQN----- -----------EMIEMECFKEIN-VYETDGTLCSDLDVNRPNPPP----------------------------------- ---------------------------------------------------------KRGFFY-RLFRRE---------- VCFKSG--YSDDEIEEPSRL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Oryzias_latipes_GRK4 ----------------------------------------------LFLEWVVPHFVMSQFFP----------------- ----------------GGGGKRNGRSKKWKEMLKLPHISQCEELRR-TVERDYTSLCEKQPIG---------RLLFRQYC D-TRPELKRCIDFMDAVAMY--ALAPDE--KRRDCGLNLLDTYFNN---------------------------------- -------------------------------------------------------------------------------- ---------GSAVHLPDIPQDWVASCRER-----LEQTPCKELFNDCTK-----------------------------IV RDHLSGAPFSSYQES-------------------MYFSRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRHYRVLGKGGFGEVCA-------------CQVRATGKM YACKK-LEKK-RVKKRKGEAMALNEKRILEKVN--SSFVVS--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGNS------GFDEQRAIFYAAEICCGLE-DLHRER-IVY---RDLKP--ENILLDDRG--HIRISDLGLAVQIP- ------EGETIRGRVGTVG-YMAP--EVIQNE-SYTFCPDWWG---LGCLVFEMIQGQSPFR----KRKERVKREEVDRR VREDQEEYS-DKFSEEAKDICRQLLAK-DPKERLGCRG-----SGGVEVKQHPIFRN---------INFKRLEA------ --------HML---DPPFVP-----DPRA--VYCKDVLDIEQFSTVK--GVNLDPTDNDFYHKFVTGSVSIPWQN----- -----------EMIEMECFKEIN-VYETDGTLSQDLDVNRPNPPP----------------------------------- ---------------------------------------------------------KRGFFY-RLFRRE---------- MNHRRSRNKPHKELNVAHEL------------------------------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Ciona_intestinalis_GRK4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------MIDA--IEERLK--APPECDQEELN--------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------QDLFSECSS-----------------------------AI TNYLSGQPFKEFCDS-------------------IYFSRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVCACQV-------------RSSGKM YACKR-LEKK-RIKKRKGEAMALNEKQILESVN--SRFVVS--LGYAYETKDALNLVLTIMNGG-DLK-----------F HIHNMGAP------GFSIHRAIFYSAEITCGLH-DLHKQR-IVY---RDLKP--ENILLDDHG--HIRISDLGLAVRIP- ------SGEKIKGRVGTVG-YMAP--EVVRNE-RYEMSPDWFG---LGCIIYEMIAGQAPFR----KRKEKVKREEVDRR VKEDTESYDDEKFTEEAKSICSMLLKK-DVKDRLGCRN----GSCASDVKAHPFFKN---------INFKRLET------ --------GKAPFGNPPFDKVPFELDPHA--VYAKDVLDIEQFSTVK--GVTIDGKDNDFYAKFSTGSVSIPWQN----- -----------EMCETSVYKDLN-VFNADGSPTPDLTPYDQQS------------------------------------- ------------------------------------------------------NPPKKGFFS-RLFGRQ---------K QPEGSKPTRRASR------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Ciona_savignyi_GRK4 ----------------------------------------------MELENIVANTVYLKARE----------------- ---GGGGK-------------RKGKSKKWREMMKFPHISLTEDLRR-TIERDYTSICEEQPIG---------QRLFRLFC E-TKPELNICRDCLEQMRNY--EETLLE--DRRQVAQTVFDKYLKDRV-------------------------------- -------------------------------------------------------------------------------- -----------RWAGCVLSCFFGRKYFIH------KYFPIEYLFYATKN-----------------------------AI TTYLSGQPFKEFCDS-------------------IYFSRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVCACQV-------------RSSGKM YACKR-LEKK-RIKKRKGEAMALNEKQILESVN--SRFVVS--LGYAYETKDALNLVLTIMNGG-DLK-----------F HIHNMGAP------GFSIHRAIFYAAEITCGLH-DLHKQR-IVY---RDLKP--ENILLDDHG--HIRISDLGLAVRIP- ------SGEKIKGRVGTVG-YMAP--EVVRNE-RYEMSPDWFG---LGCIIFEMIAGQAPFR----KRKEKVKREEVDRR VKEDTEVYDDEKFTEEAKSICSMLLKK-DVKDRLGCRN----GSCAADVKAHVFFKN---------INFKRLET------ --------GKQPFGNPPFDK------PHA--VYAKDVLDIEQFSTVK--GVTIDNKDNDFYAKFSTGSVSIPWQN----- -----------EMCDTSVYKDLC-VFNMDGTPTPDLIPYDQQS------------------------------------- ------------------------------------------------------NPPKKGLFS-RLFGRQ---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Drosophila_melanogaster_GRK4 ----------------------------------------------MELENIVANTVYLKARE----------------- ---GGSDS-------------NKGKSKKWRKILQFPHISQCINLKD-KLDISYGYVIDQQPIG---------RELFRLFC ENKRPVYFRYITFLDEVVKY--EIEYIS--NRIFIGHDIGRRFLDVEAQLELRNGSGGDALDAETQEELLLNSSNANPTE TAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGG GKCVPVGGYPDELVLDVLNDDLIAQVRNK------LNSGGKDIFAQCVN-----------------------------AV KAFLAGEPFREFESS-------------------MYFHRYLQWKWLEAQPIT---------------------------- -------------------------------------YK-TFRMYRVLGKGGFGEVCACQV-------------RATGKM YACKK-LEKK-RIKKRKGESMVLIEKQILQKIN--SPFVVN--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGGEP-----GFELERARFYAAEVACGLQ-HLHKQG-IVY---RDCKP--ENILLDDHG--HVRISDLGLAVEIP- ------EGEMVRGRVGTVG-YMAP--EVIDNE-KYAFSPDWFS---FGCLLYEMIEGQAPFR----MRKEKVKREEVDRR VKEDPEKYS-SKFNDEAKSMCQQLLAK-SIKQRLGCRNG---RMGGQDVMAHPFFHSTQ-------LNWRRLEA------ --------GML---EPPFVP-----DPHA--VYAKDVLDIEQFSTVK--GVNIDESDTNFYTKFNTGSVSISWQN----- -----------EMMETECFRELN-VFGPEECPTPDLQINAAP-------------------------------------- ------------------------------------------------------EPDKAGCFPFRRKKKQ---------P ARTQPIPIPEH-LLTTSHSVSSTTVES----------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Homo_sapiens_GRK6 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGNRKGKSKKWRQMLQFPHISQCEELRL-SLERDYHSLCERQPIG---------RLLFREFC A-TRPELSRCVAFLDGVAEY--EVTPDD--KRKACGRQLTQNFLSH---------------------------------- -------------------------------------------------------------------------------- ---------TGPDLIPEVPRQLVTNCTQR----LEQG-PCKDLFQELTR-----------------------------LT HEYLSVAPFADYLDS-------------------IYFNRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKK-LEKK-RIKKRKGEAMALNEKQILEKVN--SRFVVS--LAYAYETKDALCLVLTLMNGG-DLK-----------F HIYHMGQA------GFPEARAVFYAAEICCGLE-DLHRER-IVY---RDLKP--ENILLDDHG--HIRISDLGLAVHVP- ------EGQTIKGRVGTVG-YMAP--EVVKNE-RYTFSPDWWA---LGCLLYEMIAGQSPFQ----QRKKKIKREEVERL VKEVPEEYS-ERFSPQARSLCSQLLCK-DPAERLGCRG-----GSAREVKEHPLFKK---------LNFKRLGA------ --------GML---EPPFKP-----DPQA--IYCKDVLDIEQFSTVK--GVELEPTDQDFYQKFATGSVPIPWQN----- -----------EMVETECFQELN-VFGLDGSVPPDLDWKGQPP------------------------------------- ------------------------------------------------------APPKKGLLQ-RLFSRQ-------RIA VE--TAATARKSSPPASS------PQPEAPTSSWR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Mus_musculus_GRK6 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGNRKGKSKKWRQMLQFPHISQCEELRL-SLERDYHSLCERQPIG---------RLLFREFC A-TRPELTRCTAFLDGVSEY--EVTPDE--KRKACGRRLMQNFLSH---------------------------------- -------------------------------------------------------------------------------- ---------TGPDLIPEVPRQLVSNCAQR----LEQG-PCKDLFQELTR-----------------------------LT HEYLSTAPFADYLDS-------------------IYFNRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKK-LEKK-RIKKRKGEAMALNEKQILEKVN--SRFVVS--LAYAYETKDALCLVLTLMNGG-DLK-----------F HIYHMGQA------GFPEARAVFYAAEICCGLE-DLHRER-IVY---RDLKP--ENILLDDHG--HIRISDLGLAVHVP- ------EGQTIKGRVGTVG-YMAP--EVVRNE-RYTFSPDWWA---LGCLLYEMIAGQSPFQ----QRKKKIKREEVERL VKEVAEEYT-DRFSSQARSLCSQLLSK-DPAERLGCRG-----GGAREVKEHPLFKK---------LNFKRLGA------ --------GML---EPPFKP-----DPQA--IYCKDVLDIEQFSTVK--GVDLEPTDQDFYQKFATGSVSIPWQN----- -----------EMVETECFQELN-VFGLDGSVPPDLDWKGQPT------------------------------------- ------------------------------------------------------APPKKGLLQ-RLFSRQ-------RIA VG--TAATVRKSSPPASS------PQAEAPTGGWR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Rattus_norvegicus_GRK6 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGNRKGKSKKWRQMLQFPHISQCEELRL-SLERDYHSLCERQPIG---------RLLFREFC A-TRPELTRCTAFLDGVAEY--EVTPDE--KRKACGRRLMQNFLSH---------------------------------- -------------------------------------------------------------------------------- ---------TGPDLIPEVPRQLVSNCAQR----LEQG-PCKDLFQELTR-----------------------------LT HEYLSMAPFADYLDS-------------------IYFNRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKK-LEKK-RIKKRKGEAMALNEKQILEKVN--SRFVVS--LAYAYETKDALCLVLTLMNGG-DLK-----------F HIYHMGQA------GFPEARAVFYAAEICCGLE-DLHRER-IVY---RDLKP--ENILLDDHG--HIRISDLGLAVHVP- ------EGQTIKGRVGTVG-YMAP--EVVKNE-RYTFSPDWWA---LGCLLYEMIAGQSPFQ----QRKKKIKREEVERL VKEVAEEYT-DRFSPQARSLCSQLLNK-DPAERLGCRG-----GGAREVKEHPLFKK---------LNFKRLGA------ --------GML---EPPFKP-----DPQA--IYCKDVLDIEQFSTVK--GVDLEPTDQDFYQKFATGSVSIPWQN----- -----------EMVETECFQELN-VFGLDGSVPPDLDWKGQPT------------------------------------- ------------------------------------------------------APPKKGLLQ-RLFSRQ--------DC CG--NCSDSEEELPTRL--------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Gallus_gallus_GRK6 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGNRKGKSKKWRQMLQFPHISLCEDLRQ-ALERDYHSLCEKQPIG---------RMLFRQFC E-TRPELSRCVKFLDAVAGY--EVAPDE--KRKECGQHLIEKYLKP---------------------------------- -------------------------------------------------------------------------------- ---------KSEDYVPEVPSQLVDACCER----LEQE-PSKELFKESTK-----------------------------LI HDYLSVAPFADYLDS-------------------LYFNRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKK-LEKK-RIKKRKGEAMALNEKQILEKVN--SRFVVS--LAYAYETKDALCLVLTLMNGG-DLK-----------F HIYHMGEA------GFEEPRAAFYAAEICCGLE-DLHQER-IVY---RDLKP--ENILLDDHG--HIRISDLGLAVHVP- ------EGQTIKGRVGTVG-YMAP--EVVKNE-RYTFSPDWWA---LGCLVYEMIEGQSPFQ----QRKKKIKREEVERL VKDVQEEYS-EKFSPCARSLCTMLLCK-DPLERLGCRG-----AGAREVKEHPLFKH---------LNFRRLEA------ --------GML---DPPFKP-----DPQA--IYCKDVLDIEQFSTVK--GVELEPTDNDFYQKFATGSVPIPWQN----- -----------EMIETDCFKELN-VFSTDGTVPPDLDWKGQPS------------------------------------- ------------------------------------------------------PQPKKGLLQ-RFFSRQR------TVV G---TAATVRKSPPGLPAA----QPLPQDLAGSWT--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Anolis_carolinensis_GRK6 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGNRKGKSKKWRQMLQFPHVSQCEDLRH-ALEGDYHSLCEKQPIG---------RLLFRQFC E-TRLELMRCVKFLDAVAEY--EVTPDE--NRKECGQQLIDTYLNP---------------------------------- -------------------------------------------------------------------------------- ---------QSADHVPEVPLELVTLCSER----LEEEEPGKELFKESTK-----------------------------LI HDYLSVAPFADYLDS-------------------IYFNRFLQWKSLERQHVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKK-LEKK-RIKKRKGEAMALNEKQILEKVN--SRFVVS--LAYAYETKDALCLVLTLMNGG-DLK-----------F HIYHMGEA------GFEEPRAVFYAAEICCGLE-DLHHER-IVY---RDLKP--ENILLDDHG--HIRISDLGLAVYVP- ------EGQTIKGRVGTVG-YMAP--EVVKNE-RYTFSPDWWA---LGCLLYEMIEGQSPFQ----QRRKKIKREEVERL VKEVQEEYS-EKFSPASRSLCSMLLCK-DPMDRLGCGD-----AGAQGVKEHPLFKH---------LNFKRLEA------ --------GML---DPPFKP-----DPQA--IYCKDVLDIEQFSTVK--GVELEPTDHDFYHKFATGSVPIPWQN----- -----------EMIETECFKELN-VFGPDGAVPPDLDWKGQQP------------------------------------- ------------------------------------------------------TVPKKGLLQ-RLFSRQ-------DCC G---NCSESEEEPTRL---------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Danio_rerio_GRK6 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGNRKGKSKKWKQMLQFPHISLCEELRQ-TIEKDYNSLCERQPIG---------RLLFRQFC D-TRPELRRCVRFLDAVAEY--EVTPDE--KRKECGQELLDKYLNT---------------------------------- -------------------------------------------------------------------------------- ---------KSEDYIPEVTEEMVTKCADR----LQQE-ACKELFMECTK-----------------------------LI HDYLSVAPFADYLDS-------------------MYYSRFLQWKWLERQPIT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKK-LEKK-RIKKRKGESMALNEKQILEKVN--SRFVVS--LAYAYETKDALCLVLTLMNGG-DLK-----------F HIYHMGEA------GFDEKRAVFYAAEICCGLE-DLHRER-IVY---RDLKP--ENILLDDHG--HIRISDLGLAVHVP- ------EGQTIKGRVGTVG-YMAP--EVVKNE-RYTFSPDWWA---LGCLLYEMIEGQSPFQ----QRKKKIKREEVERL VKEVEEEYS-SKFSEDAKSLCKMLLAK-DPSERLGCQG-----GGASEVKAHLIFRS---------INFKRLAA------ --------GML---EAPFIP-----DPQA--IYCKDVLDIEQFSTVK--GVELEPKDDSFYSKVSTGSVPIPWQN----- -----------EMIETECFKELN-ILNLDGTVPPDLDWRGQPS------------------------------------- ------------------------------------------------------PPPKQGLLQ-RLFGRQ--------DC CG--NCSDSEEEPTRL---------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Takifugu_rubripes_GRK6 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGNRKGKSKKWKQMLQFPHISMCEELRQ-NTEKDYSTLCERQPIG---------RLLFRQFC D-TRPELRCCVKFLDAVAEY--EVTPDE--KRRECGQELVNKYFNP---------------------------------- -------------------------------------------------------------------------------- ---------KSEDHVPEVEEAMLVQCADR----LQQE-ACKELFKDCTK-----------------------------LI HDYLSMAPFADYLDS-------------------MYYNRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKK-LEKK-RIKKRKGESMALNEKQILEKVN--SRFVVS--LAYAYETKDALCLVLTLMNGG-DLK-----------F HIYHMGES------GFDEKRAVFYSAEICCGLE-DLHRER-IVYRC-RDLKP--ENILLDDHG--HIRISDLGLAVHVP- ------EGQTIKGRVGTVG-YMAP--EVVKNE-RYTFSPDWWA---LGCLLYEMIEGQSPFQ----QRKKKIKREEVEKL VREVEEEYS-SKFSEDAKSLCKMLLAK-DPKVRLGCQG-----NGASEVKAHPIFRS---------INFKRLEA------ --------GML---EPPFIP-----DPQA--IYCKDVLDIEQFSTVK--GVDLEPKDESFYSKVSTGSVSIPWQN----- -----------EMIETGCFAELN-VFYQDGTVPPDLDWRGQPS------------------------------------- ------------------------------------------------------PPPKQGLLQ-RLFGRQFSLTGVCVTD VG--ASAPPEQSPAVKVPCWR----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Gasterosteus_aculeatus_GRK6 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGNRKGKSKKWKQLLQFPHISLCEELRQ-TTEKDYSSLCERQPIG---------RLLFRQFC E-TQPELRRCVKFLDAVAEY--EVAPDE--KRKECGQELVNKYFDP---------------------------------- -------------------------------------------------------------------------------- ---------KVEDYVPEVEQAMMAQCAER----LQQE-ACKELFKDCTK-----------------------------LI HGYLSVAPFADYLDS-------------------MYYNRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKK-LEKK-RIKKRKGESMALNEKQILEKVN--SRFVVS--LAYAYETKDALCLVLTLMNGG-DLK-----------F HIYHMGDA------GFDEKRAIFYSAEICCGLE-DLHRER-IVY---RDLKP--ENILLDDHG--HIRISDLGLAVHVP- ------EGQTIKGRVGTVG-YMAP--EVVKNE-RYTFSPDWWA---LGCLLYEMIEGQSPFQ----QRKKKIKREEVERL VREVEEEYS-SKFSEDAKSLCRMLLAK-DPAERTGCQG-----GGASEVKAHTIFCS---------INFKRLVA------ --------GML---QAPFTP-----DPQA--IYCKDVLDIEQFSTVK--GVELEPKDESFYSKVSTGCVSIPWQD----- -----------EMIETECFTELN-VFHQDGTVPPDLDWRGQPS------------------------------------- ------------------------------------------------------PPPKQGLLQ-RLFGRQ--------DC CG--NCSDSDESPTRL---------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Homo_sapiens_SGK3 -------------------------------------------------------------------------------- ------------------------------MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRR YAEFDKLYNTLKKQFPAMALKIPAKRIFGDNFDP---------------------------------------------- -------------------------------------------------------------------------------- -----------DFIKQRR--AGLNEFIQN-------LVRYPELYNHPDVR-----------------------------A FLQMDSPKHQSDPSE---DEDERSSQ-----------KLHSTSQNIN--------------------------LGPS--- --------GNPH----------------------AKPTDFDF--LKVIGKGSFGKVLLAKRKLDG-------------KF YAVKVLQKKIV-L--NRKEQKHIMAERN-VLLKNVKHPFL-VGLHYSFQTTEKLYFVLDFVNGGE------------LFF HLQRE--------RSFPEHRARFYAAEIASALG-YLHSIK-IVYR---DLK--PENILLDSVG--HVVLTDFGLCKEGIA ------ISDTTTTFCGTPE-YLAP--EVIRKQPYDNT-VDWWC---LGAVLYEMLYGLPPFY------CRDVAEMYDNIL H--KPLSLRPG-VSLTAWSILEELLEK-DRQNRLGA-KEDF-----LEIQNHPFFES---------LSWADLVQ------ --------KKIP---PPFNPNVA------------GPDDIRNFDTAFTEETVPYSVCVS----SDYSIVN---------- ---------ASVLEADDAFVGFSYA------------------------------------------------------- -------------------------------------------------------PPSEDLFL----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Mus_musculus_SGK3 -------------------------------------------------------------------------------- ------------------------------MQRDCIMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRR YAEFDKLYNSLKKQFPAMALKIPAKRIFGDNFDP---------------------------------------------- -------------------------------------------------------------------------------- -----------DFIKQRR--AGLNEFIQN-------LVRYPELYNHPDVR-----------------------------A FLQMDSPRHQSDPSE---DEDERSTS-----------KPHSTSRNIN--------------------------LGPT--- --------GNPH----------------------AKPTDFDF--LKVIGKGSFGKVLLAKRKLDG-------------KF YAVKVLQKKIV-L--NRKEQKHIMAERN-VLLKNVKHPFL-VGLHYSFQTTEKLYFVLDFVNGGE------------LFF HLQRE--------RSFPEPRARFYAAEIASALG-YLHSIK-IVYR---DLK--PENILLDSMG--HVVLTDFGLCKEGIA ------ISDTTTTFCGTPE-YLAP--EVIRKQPYDNT-VDWWC---LGAVLYEMLYGLPPFY------CRDVAEMYDNIL H--KPLNLRPG-VSLTAWSILEELLEK-NRQNRLGA-KEDF-----LEIQNHPFFES---------LSWTDLVQ------ --------KKIP---PPFNPNVA------------GPDDIRNFDAVFTEETVPYSVCVS----SDYSIVN---------- ---------ASVLEADDAFVGFSYA------------------------------------------------------- -------------------------------------------------------PPSEDLFL----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Rattus_norvegicus_SGK3 -------------------------------------------------------------------------------- ------------------------------MQRDCTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRR YAEFDKLYNSLKKQFPAMALKIPAKRIFGDNFDP---------------------------------------------- -------------------------------------------------------------------------------- -----------DFIKQRR--AGLNEFIQN-------LVRYPELYNHPDVR-----------------------------A FLQMDSPRHQSDPSE---DEDERSTP-----------KPHSTSRNIN--------------------------LGPT--- --------GNPQ----------------------SPPPPVFL--LKYLRKGRIIKVLLAKRKLDG-------------KF YAVKVLQKKIV-L--NRKEQKHIMAERN-VLLKNVKHPFL-VGLHYSFQTTEKLYFVLDFVNGGE------------LFF HLQRE--------RSFPEPRARFYAAEIASALG-YLHSIK-IVYR---DLK--PENILLDSMG--HVVLTDFGLCKEGIA ------ISDTTTTFCGTPE-YLAP--EVIRKQPYDNT-VDWWC---LGAVLYEMLYGLPPFY------CRDVAEMYDNIL H--KPLNLRPG-VSLTAWSILEELLEK-NRQNRLGA-KEDF-----LEIQNHPFFES---------LSWTDLVQ------ --------KKIP---PPFNPNVA------------GPDDIRNFDAVFTEETVPYSVCVS----SDYSIVN---------- ---------ASVLEADDAFVGFSYA------------------------------------------------------- -------------------------------------------------------PPSEDLFL----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Gallus_gallus_SGK3 -------------------------------------------------------------------------------- ------------------------------------MDLKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRNEWFVFRR YAEFDKLYNTLKKQFPTMNLKIPAKRIFGDNFDP---------------------------------------------- -------------------------------------------------------------------------------- -----------DFIKQRR--AGLNEFIQN-------LVRQPELCNHPDVR-----------------------------A FLQMDNPKHQSDPSE---DEDERSNQ-----------KLNSTSPNIN--------------------------LGPS--- --------GNPH----------------------AKPTDFDF--LKVIGKGSFGKVLLAKRKLDG-------------KY YAVKVLQKKIV-L--NRKEQKHIMAERN-VLLKNVKHPFL-VGLHYSFQTTEKLYFVLDFVNGGE------------LFF HLQRE--------RSFPEHRARFYAAEIASALG-YLHSIN-IVYR---DLK--PENILLDSLG--HVVLTDFGLCKEGIA ------SSDTTATFCGTPE-YLAP--EVIKKQPYDNT-VDWWC---LGAVLYEMLYGLPPFY------CRDVAEMYENIL H--KPLVLRPG-ISLTAWSILEELLEK-DRQSRLGA-KEDF-----LEIQKHPFFES---------LSWTDLLQ------ --------KKIP---PPFNPNVV------------GPDDIGNFDAVFTEEMVPYSVCIS----SDYSIVN---------- ---------ASVLEADDAFVGFSYA------------------------------------------------------- -------------------------------------------------------PPSEDMFS----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Anolis_carolinensis_SGK3 -------------------------------------------------------------------------------- ------------------------------------MDLKESCPSVSIPSSDEHRVKKKRFTVYKVLVSVGTNEWFVFRR YAEFDKLYHTLRKQFPTMNLRIPAKRIFGDNFDP---------------------------------------------- -------------------------------------------------------------------------------- -----------DFIKQRR--AGLNEFIQN-------LVQQPELCNHPDVR-----------------------------S FLQMDNPKHQYDPSE---DEDERNSQ-----------KLNSISQNIN--------------------------LGPS--- --------GNPH----------------------AKPTDFDF--LKVIGKGSFGKVLLAKRKLDG-------------KF YAVKVLQKKIV-L--NRKEQKHIMAERN-VLLKNVKHPFL-VGLHYSFQTTEKLYFVLDFVNGGE------------LFF HLQKE--------RSFPEHRARFYAAEIASALG-YLHSVK-IVYR---DLK--PENILLDSLG--HVVLTDFGLCKEGMA ------TSDTTATFCGTPE-YLAP--EVIRKQPYDNT-VDWWC---LGAVLYEMLYGLPPFY------CRDVAEMYENIL H--KPLHLRPG-ISLTAWSILEELLEK-DRQNRLGA-KEDF-----LEIQSHPFFES---------LNWTDLLQ------ --------KKIP---PPFNPNVS------------GPDDIRNFDTAFTEEMVPYSVCIS----SDYNIVN---------- ---------ASVLEADDAFIGFSYA------------------------------------------------------- -------------------------------------------------------PPSEDLFH----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Danio_rerio_SGK3a -------------------------------------------------------------------------------- ------------------------------------MEEQPSCPNVSIPCYNEQRDKKKRYTVYKVMVSVGRHEWFVFRR YAEFDKLYNTLKKQFPALNLKIPAKRIFGDNFDP---------------------------------------------- -------------------------------------------------------------------------------- -----------EFIKQRR--AGLHEFIQR-------IVSHSQLCSHPDVK-----------------------------V FLQMDKAKNFSDGSE---DEDD---------------KSNSTSRNIN--------------------------LGPS--- --------ANPH----------------------AKPTDFDF--LKVIGKGSFGKVLLAKRKRDG-------------KC YAIKVLQKKVI-L--NRREQKHIMAERN-VLLKNVKHPFL-VGLHYSFQTTDKLYFVLDFVNGGE------------LFF HLQKE--------RTFPEPRAKFYIAEMASALG-YLHSLN-IVYR---DLK--PENILLDSQG--HIVLTDFGLCKEGIS ------QADTTTTFCGTPE-YLAP--EVLRKQPYDNT-VDWWC---LGSVLYEMLYGLPPFY------SRDTHEMYDNIL H--KELVMRPG-ASTAAWSILQTLLEK-DHTRRLGY-RDDF-----NEVKEHEFFSS---------INWYDLEQ------ --------KKLS---PPFNPSVE------------SQYDISNFDPEFTEETVPNSVCFS----SGPSIVN---------- ---------ASVMEADDAFLGFSYA------------------------------------------------------- -------------------------------------------------------PPSEDSFL----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Takifugu_rubripes_SGK3 -------------------------------------------------------------------------------- ------------------------------TPAAATMEEQPSLPNVSIPCHDEQRDKKKRYTVYKVLVSVGQQEWFVFRR YAEFDKLYNALRKQFPSMNLKIPAKRIFGDNFEP---------------------------------------------- -------------------------------------------------------------------------------- -----------EFIKQRR--AGLHEFIKK-------IVSHPQLCNHPDVR-----------------------------A FLQMDKIRNFSDASE---DEDEKVRRF-------P--NNNSTSGNIN--------------------------LGPS--- --------ANPQ----------------------AKPTDFDF--LKVIGKGSFGKVFLAKRKTDG-------------KN YAVKVLQKKVI-L--NRKEQKHIMAERN-VLLKNVKHPFL-VGLHYSFQTTDKLYFVLDFINGGE------------LFF HLQKE--------RTFPEPRAKFYIAEMASALG-YLHSLN-IVYR---DLK--PENILLDHEG--HIVLTDFGLCKEGIS ------QSDTTSTFCGTPE-YLAP--EVLRKQPYDNT-VDWWC---LGSVLYEMLFGLPPFY------SRDTHEMYDNIL H--KPLGMRPG-ASNTAWSLLQGLLEK-DGTHRLGS-INDF-----EEIKAHSFFYS---------INWDDLVQ------ --------KKIP---PPFTPKVN------------SFSDISNFDPEFTEEMVPKSVCWS----QEHSIVN---------- ---------ASVMEADDAFVGFSYA------------------------------------------------------- -------------------------------------------------------PPSEDSFL----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Tetraodon_nigroviridis_SGK3 -------------------------------------------------------------------------------- ------------------------------MPAPAIMEEQPGLPNVSIPCHDEQRDKKKRYTVYKVLVSVGQQEWFVFRR YAEFDKLYNTLRKQFPSVNLKIPAKRIFGDNFEP---------------------------------------------- -------------------------------------------------------------------------------- -----------EFIKQRR--AGLHEFIKK-------IVSHPQLCNHPDVR-----------------------------A FLQMNKIRNFSDGSE---DEDE---------------KNNSTSGNIN--------------------------LGPS--- --------ANPQ----------------------AKPTDFDF--LKVIGKGSFGKVFLAKRKIDG-------------KY YAIKVLQKKVI-L--NRKEQKHIMAERN-VLLKNVKHPFL-VGLHYSFQSTDKLYFVLDFINGGE------------LFF HLQKE--------RTFPEPRAKFYIAEMASALG-YLHSLN-IVYR---DLK--PENILLDHEG--HIVLTDFGLCKEGIS ------QSDTTSTFCGTPE-YLAP--EVLRKQPYDNT-VDWWC---LGSVLYEMLFGLPPFY------SRDTHEMYDNIL H--KPLAMRAG-ASSTAWSLLQGLLEK-DGTHRLGS-RNDF-----DEIKVHNFFSS---------INWDDLVQ------ --------KKIP---PPFTPKVN------------SFSDISNFDPEFTEEMVPKSVCWS----QDHSIVN---------- ---------ASVMEADDAFLGFSYA------------------------------------------------------- -------------------------------------------------------PPSEDSFL----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Gasterosteus_aculeatus_SGK3 -------------------------------------------------------------------------------- --------------------------------MPTKMEEQTGQPNVSIPCHNEQRDKKKRYTVYKVIVNVGQQEWFVFRR YAEFDKLYNTLRKQFASTNLKIPAKRIFGDNFDP---------------------------------------------- -------------------------------------------------------------------------------- -----------EFIKQRR--AGLHEFIKR-------IVSDPQLCNQPDVR-----------------------------A FLLMDKMQSFSDASE---DEDD---------------KNSSTSRNIN--------------------------LGPS--- --------GNPQ----------------------AKPTDFDF--LKVIGKGSFGKVFLAKLKHDE-------------KY YAVKVLQKKVI-L--NRKEQKHIMAERN-VLLKNVKHPFL-VGLQYSFQTTDKLYFVLDFVNGGE------------LFF HLQKE--------RTFPEPRAKFYIAEIASALG-YLHSLN-IVYR---DLK--PENILLDHEG--HIILTDFGLCKEGIS ------QTDTTTTFCGTPE-YLAP--EVLRKQPYDNT-VDWWC---LGSVLYEMLYGLPPFY------SRDTHQMYDNIL H--KPLVMRPG-ASSTAWSLLQGLLEK-EGMHRLGS-MDDF-----NEIKAHSFFFS---------INWDDLEQ------ --------KKIP---PPFTPNVS------------SYCDISNFDPEFTEEMVPNSICWS----KDHSVVN---------- ---------ASVMEADDAFVGFSYA------------------------------------------------------- -------------------------------------------------------PASDDFFL----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Oryzias_latipes_SGK3 -------------------------------------------------------------------------------- ------------------------------MLSHAEMEERSSLPSVSIPCHNEQRDKKKRYTVYKVLVSVGQHEWFVFRR YAEFDKLYNTLRKQFPSMNLKIPAKRIFGDNFDP---------------------------------------------- -------------------------------------------------------------------------------- -----------EFIQQRR--AGLHEFIKR-------LVSHPQLCNHPDVK-----------------------------S FLQMDKRQHLADASE---DEDD---------------KNSSTSRDIN--------------------------LGPS--- --------GNPQ----------------------AKPTDFDF--LKVIGKGSFGKVFLAKRKHDG-------------KF YAIKVLQKKVI-L--NRKEQKHIMAERN-VLVKNVKHPFL-VGLHYSFQTTDKLYFVLDFVNGGE------------LFF HLQKE--------RTFPEPRARFYIAEMASALG-YLHSLK-IVYR---DLK--PENILLDHEG--HIVLTDFGLCKEGIS ------QTDTTTTFCGTPE-YLAP--EVLKKHPYDNT-VDWWC---LGSVLYEMLFGLPPFY------SRDTHEMYDNIL H--KPLAMRPG-ASSTAWSLLQGLLEK-DGTQRLGS-NGDFV-CFQNEIKVHNFFSS---------INWDDLVQ------ --------KKIP---PPFIPNVT------------SCCDISNFDPEFTEENVPNSICWT----QSHSVVN---------- ---------ASVMEADDAFLGFSYA------------------------------------------------------- -------------------------------------------------------PPSDDSFL----------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Ciona_intestinalis_SGK3 -------------------------------------------------------------------------------- ------------------------MSDTTTGPSMASIVKEG----WLQKRGEYIRNWRRRYFVLK---TDGSFLGYKDKP --DPDNH-QEPLNNFSVLK------------------------------------------------------------- -------------------------------------------------------------------------------- ----------SQVMRKDQQRENAFVFVVR-CLQWTTIIERTFTSTSKVDR------------------------------ EEWMKAIEGVSDQLQ----HSPEEK------SVTEDESKKTSDHKVINTVCENTF--------------NKH-------- -----ANPLIKQPENEFIKPAKS----------NKTLTDFEF--LEVLGKGTFGKVILVKEKKTE-------------EF HAMKILKKEVI-V--AKDEVTHTLTENR--VLQQTRHPFL-TSLKYSFQTNDYLCFVMEYVNGGEI------------FF HLSRD--------RVFSEDRARFYGAEIILALD-YLHQQE-VIYR---DLK--LENLLLDSEG--HIKITDFGLCKEEIR ------FGTTTKTFCGTPE-YLAP-EV-LEDNDYGRS-VDWWG---LGVVMYEMMCGRLPFY------NRDHDVLFELIL M--DDLRFPSG-LSKEGKSLLSELLNK-DPLKRLGSSQSDA-----QEVMAHRFFSA---------VVWKDILE------ --------KKVP---PPFKPQVS------------SITDTRYFDKEFTAQPVQLTPPD-----QSSS------------- ----------MDDTNRPHFEAFSYS------------------------------------------------------- --------------------------------------------------------SSGSHLDKGSRNHR---------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Drosophila_melanogaster_SGK3 ----------MNYLPFVLQRRSTVVASAPAPGSASRIPESPTTTGSNIINIIYSQSTHPNSSPTSGSAEKFSWQQSWPSR TSAAPTHDSGTMSINTTFDLSSPSVTSGHALTEQTQVVKEG----WLMKRGEHIKNWRQRYFVLH---SDGRLMGYRSKP ADSASTPSDFLLNNFTVRG------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CQIMTVDR--PKPFTFIIR-GLQWTTVIERTFAVESELER------------------------------ QQWTEAIRNVSSRLI----DVGEVAMT------PSEQTDMTDVDMAT------------------------IAEDELSEQ FSVQGTTCN-SSGVK------------------KVTLENFEF--LKVLGKGTFGKVILCREKATA-------------KL YAIKILKKEVI-I--QKDEVAHTLTESR--VLKSTNHPFL-ISLKYSFQTNDRLCFVMQYVNGGEL------------FW HLSHE--------RIFTEDRTRFYGAEIISALG-YLHSQG-IIYR---DLK--LENLLLDKDG--HIKVADFGLCKEDIT ------YGRTTKTFCGTPE-YLAP--EVLDDNDYGQA-VDWWG---TGVVMYEMICGRLPFY------NRDHDVLFTLIL V--EEVKFPRN-ITDEAKNLLAGLLAK-DPKKRLGGGKDDV-----KEIQAHPFFAS---------INWTDLVL------ --------KKIP---PPFKPQVT------------SDTDTRYFDKEFTGESVELTPPD-----PTGPLGS---------- -----------IAEEP-LFPQFSYQG------------------------------------------------------ ------------------------------------------------------DMASTLGTSSHISTSTSLASMQ---- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Homo_sapiens_GRK5 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGKRKGKSKKWKEILKFPHISQCEDLRR-TIDRDYCSLCDKQPIG---------RLLFRQFC E-TRPGLECYIQFLDSVAEY--EVTPDE--KLGEKGKEIMTKYLTP---------------------------------- -------------------------------------------------------------------------------- ---------KSPVFIAQVGQDLVSQTEEK----LLQK-PCKELFSACAQS-----------------------------V HEYLRGEPFHEYLDS-------------------MFFDRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKR-LEKK-RIKKRKGESMALNEKQILEKVN--SQFVVN--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGNP------GFEEERALFYAAEILCGLE-DLHREN-TVY---RDLKP--ENILLDDYG--HIRISDLGLAVKIP- ------EGDLIRGRVGTVG-YMAP--EVLNNQ-RYGLSPDYWG---LGCLIYEMIEGQSPFR----GRKEKVKREEVDRR VLETEEVYS-HKFSEEAKSICKMLLTK-DAKQRLGCQE-----EGAAEVKRHPFFRN---------MNFKRLEA------ --------GML---DPPFVP-----DPRA--VYCKDVLDIEQFSTVK--GVNLDHTDDDFYSKFSTGSVSIPWQN----- -----------EMIETECFKELN-VFGPNGTLPPDLNRNHPPE------------------------------------- -------------------------------------------------------PPKKGLLQ-RLFKRQ--------HQ NNSKSSPSSKTSFNHHINSNHVS---SNSTGSS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Mus_musculus_GRK5 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGKRKGKSKKWKEILKFPHISQCEDLRR-TIDRDYYSLCDKQPIG---------RLLFRQFC E-TRPGLECYIQFLDLVAEY--EITPDE--NLGAKGKEIMTKYLTP---------------------------------- -------------------------------------------------------------------------------- ---------KSPVFIAQVGQDLVSQTEKK----LLQS-PCKELFSACAQS-----------------------------V HDYLKGDPFHEYLDS-------------------MYFDRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKR-LEKK-RIKKRKGESMALNEKQILEKVN--SQFVVN--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGNP------GFEEERALFYAAEILCGLE-DLHREN-TVY---RDLKP--ENILLDDYG--HIRISDLGLAVKIP- ------EGDLIRGRVGTVG-YMAP--EVLNNQ-RYGLSPDYWG---LGCLIYEMIEGQSPFR----GRKEKVKREEVDRR VLETEEVYS-SKFSEEAKSICNMLLTK-DSKQRLGCQE-----EGAAEVKRHPFFRN---------MNFKRLEA------ --------GML---DPPFVP-----DPRA--VYCKDVLDIEQFSTVK--GVNLDHTDDDFYSKFSTGSVPIPWQN----- -----------EMIETECFKELN-VFGPNGTLSPDLNRSQPPE------------------------------------- -------------------------------------------------------PPKKGLFH-RLFRRQ--------HQ SNSKSSPTPKTSCNHRINSNHIN---SNSTGSS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Rattus_norvegicus_GRK5 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGKRKGKSKKWKEILKFPHISQCEDLRR-TIDRDYYSLCDKQPIG---------RLLFRQFC E-TRPGLECYIQFLDLVAEY--EITPDE--NLGAKGKEIMTKYLSP---------------------------------- -------------------------------------------------------------------------------- ---------KSPVFIAQVGQDLVSQTEKK----LLQS-PCKELFSACAQS-----------------------------V HDYLKGDPFHEYLDS-------------------MYFDRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKR-LEKK-RIKKRKGESMALNEKQILEKVN--SQFVVN--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGNP------GFEEERALFYAAEILCGLE-DLHREN-TVY---RDLKP--ENILLDDYG--HIRISDLGLAVKIP- ------EGDLIRGRVGTVG-YMAP--EVLNNQ-RYGLSPDYWG---LGCLIYEMIEGQSPFR----GRKEKVKREEVDRR VLETEEVYS-PKFSEEAKSICNMLLTK-DSKQRLGCQE-----EGAAEVKRHPFFRN---------MNFKRLEA------ --------GML---DPPFVP-----DPRA--VYCKDVLDIEQFSTVK--GVNLDHTDDDFYSKFSTGSVPIPWQN----- -----------EMIETECFKELN-VFGPNGTLSPDLNRSQPPE------------------------------------- -------------------------------------------------------PPKKGLFH-RLFRRQ--------HQ NNSKSSPTPKTSCNHRINSNHIN---SNSTGSS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Gallus_gallus_GRK5 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGKRKGKSKKWKEILKFPHISQCEDLRK-TIERDYCSICEKQPIG---------RLLFRQFC E-TRPELECCIRFLDSVAEY--EIAPDE--KLGEKGKEIMMKYLTP---------------------------------- -------------------------------------------------------------------------------- ---------ESPTYVPEVSQDLIQQTEEN----LENS-PCKELFSHCTKS-----------------------------V LDHLSGEPFQEYLNS-------------------MYFDRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKR-LEKK-RIKKRKGESMALNEKQILEKVN--SQFVVN--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGNP------GFEEERALFYAAEILCGLE-DLHREN-TVY---RDLKP--ENILLDDYG--HIRISDLGLAVKIP- ------EGESIRGRVGTVG-YMAP--EVLNNQ-RYTLSPDYWG---LGCLIYEMIAGQSPFR----GRKEKVKREEVDRR VLETEEVYS-HKFSEEAKSICKMLLTK-DVKQRLGCQG-----EGATEVKRHPFFKS---------MNFKRLEA------ --------GML---DPPFVP-----DPRA--VYCKDVLDIEQFSTVK--GVNLDQTDDDFYSKFSTGSVSIPWQN----- -----------EMIETECFKELN-VFGPNGTISPDLNKSYPPE------------------------------------- -------------------------------------------------------PPKKGLLQ-RIFKRQ--------HQ NNSKSSSNSKASLNHHINSNHEERQLTEELHSS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Anolis_carolinensis_GRK5 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGKRKGKSKKWKEILKFPHISQCEDLRK-TIERDYYSLCDKQPIG---------RLLFRQFC E-TRPELDCCIRFLDSVAEY--EITPDA--KLGEKGKEIVMKYLIP---------------------------------- -------------------------------------------------------------------------------- ---------ESPTFVAEVNQDLVLQTEEI----LENS-PCKELFSPCVKS-----------------------------V REYLSGEPFQEYSES-------------------MYFDRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKR-LEKK-RIKKRKGESMALNEKQILEKVN--SQFVVN--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGNP------GFEEERALFYAAEILCGLE-DLHREN-TVY---RDLKP--ENILLDDYG--HIRISDLGLAVKIP- ------EGESIRGRVGTVG-YMAP--EVLNNQ-RYTLSPDYWG---LGCLIYEMIAGQSPFR----GRKEKVKREEVDRR VLETEEVYS-HKFTEEAKSICKMLLTK-DVKQRLGCHE-----EGAVEVKKHPFFKN---------MNFKRLEA------ --------GML---DPPFVP-----DPRA--VYCKDVLDIEQFSTVK--GVNLDQTDDDFYSKFSTGSVSIPWQN----- -----------EMIETECFKELN-VFGPNGTISPDLNKSFPPE------------------------------------- -------------------------------------------------------PPKKGLLH-RIFKRQ--------HQ NNSKSSPNAKANLNHHINANHVS---SNSTGSS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Xenopus_tropicalis_GRK5 -------------------------------------------------------------------------------- ----------------GGGGKRKGKSKKWKEILKFPHISQCEELRR-ATERDYYNLCEKQPIG---------RLLFRQFC E-AQPDLECLIHFLDAVAEY--EVTPDE--KLGEKGKEIILKYLTP---------------------------------- -------------------------------------------------------------------------------- ---------ESPVYVSEVGQDIVHQMEEK----LEIS-PYKELFSHCAKS-----------------------------V SDFLSGEPFHCYLES-------------------MYFDRFLQWKWLERQPVT---------------------------- -------------------------------------KN-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKR-LEKK-RIKKRKGESMALNEKQILEKVT--SRFVVN--LAYAYETKDALCLVLTLMNGG-DLK-----------F HIYNMGNP------GFQEERASFYAAEILCGLG-DLHRES-IVY---RDLKP--ENILLDDYG--HIRISDLGLAVKIP- ------EGDSIRGRVGTVG-YMAP--EVLNNQ-KYTFSPDFWG---LGCLIYEMIAGQSPFR----GRKEKVKREEVDRR VLETEEVYT-QKFSEEAKSVCKLLLTK-EVKRRLGCQE-----GGAVDVKRHPFFRV---------INFKRLEA------ --------GIM---DPPFVP-----DPRA--VYCKDVLDIEQFSTVK--GVNLDQTDDDFYTKFSTGSVSIPWQN----- -----------EMTETECFKELN-VYGPNRTLSPDLNRSHPPE------------------------------------- -------------------------------------------------------PPKKSLLH-RIFKRQ--------HQ NNSNSSPCTKSSLNHDVNTNHIS---TNSTGSS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Danio_rerio_GRK5 ----------------------------------------------MELENIVANTVLLKARE----------------- ----------------GGGGKRKGRSKKWREILRFPHISQCTELNK-AIERDYVCLCERQPIG---------RLLFRLYC E-TQPELQRCIQLLDAMDDY--EVSPDE--KRKSRGDEIIKKFLNK---------------------------------- -------------------------------------------------------------------------------- ----------QSSECVDVAESLAERCKEN----LELS-PCKEIFSDCRK-----------------------------AL HDYLSGAPFTDYQNS-------------------MYFDRFLQWKMLERQPIT---------------------------- -------------------------------------KD-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKK-LEKK-RIKKRKGEAMALNEKQILEKVN--SRFVVS--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGTP------GFEKERVQLYAAEICCGLE-DLHRES-IIY---RDLKP--ENILLDDNG--HIRISDLGLAIKVP- ------DGEQIRGRVGTVG-YMAP--EVINNE-RYSMSPDWWG---LGCLIYEMTAGRSPFR----ARKERVKREDVEKR VQEEEEEYS-DKFSEDTKAICRMLLSK-DPKQRLGCQT-----DRASGVKAHPFFKN---------INFKRLEA------ --------GIL---EPSFVP-----DPRA--VYCKDVLDIEQFSTVK--GVNLDQTDNDFYSKFATGSVSIPWQN----- -----------EMIETECFNDLN-VFGPQGTRPPDLDWN-QPP------------------------------------- ------------------------------------------------------EPPRRSLLD-RIFRRH---------- VRISSTSTTEEHPREQSS-------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Oryzias_latipes_GRK5_a ----------------------------------------------ILLQYFYLHVSFLTA------------------- ----------------GGGGKRKGRSKKWKEILRFPHISQCVELEK-IIEKDYDSICEKQPIG---------RLLFRMYC D-TKPSLQRCIHLLDAMEDY--EVSPDE--NRKSRGEEIIKSFLSKL--------------------------------- -------------------------------------------------------------------------------- ---------MKSPQKVDIAEGFAEQCRKN----LELS-PCKEIFSTCLKTR---------------------------AV HDYLSGVPFSDFQKS-------------------MYFDRFLQWKMLERQPIT---------------------------- -------------------------------------KD-TFRQYRVLGKGGFGEVC---A----------CQVRATGKM YACKK-LEKK-RIKKRKGEAMALNEKQILEKVN--SRFVVS--LAYAYETKDALCLVLTIMNGG-DLK-----------F HIYNMGTP------GFEKNRVQFYAAQICCGLT-HLHRES-IVY---RDLKP--ENILLDDNG--HIRISDLGLAIKVP- ------EGELIRGRVGTVG-YMAP--EVINNE-KYAMSPDWWG---LGCLIYEMTAGRSPFR----ARKERVKREEVERR VQEEEEEYN-DKFTEDAKAICRMLLTK-DPKQRLGCKS-----DGAEGVKAHSFFKS---------INFKRMEA------ --------GIV---DPPFFP-----DPRA--VYCKDVLDIEQFSTVK--GVNLDQTDNDFYSKFATGSVSIPWQN----- -----------EMIETECFRDLN-VFGPQGTRPPDLDWN-QPP------------------------------------- ------------------------------------------------------EPPRRSLLD-RIFRRHLSSNSLQHPE VSISNSRVQSSSVNSVDSMSN----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Homo_sapiens_AKT3 -------------------------------------------------------------------------------- -------------------------------MSDVTIVKEG----WVQKRGEYIKNWRPRYFLLK---TDGSFIGYKEKP -QDVD-L-PYPLNNFSVAK------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CQLMKTER--PKPNTFIIR-CLQWTTVIERTFHVDTPEER-----------------------------E E-WTEAIQAVADRLQ----RQEEER--------MN-CSPTSQIDNIG--------------------------EEEMD-- -----ASTTHHKRK---------------------TMNDFDY--LKLLGKGTFGKVILVREKASG-------------KY YAMKILKKEVI-I--AKDEVAHTLTESR--VLKNTRHPFL-TSLKYSFQTKDRLCFVMEYVNGGEL------------FF HLSRE--------RVFSEDRTRFYGAEIVSALD-YLHSGK-IVYR---DLK--LENLMLDKDG--HIKITDFGLCKEGIT ------DAATMKTFCGTPE-YLAP--EVLEDNDYGRA-VDWWG---LGVVMYEMMCGRLPFY------NQDHEKLFELIL M--EDIKFPRT-LSSDAKSLLSGLLIK-DPNKRLGGGPDDA-----KEIMRHSFFSG---------VNWQDVYD------ --------KKLV---PPFKPQVT------------SETDTRYFDEEFTAQTITITPPEK---YDEDGMDC---------- ----------MDNERRPHFPQFSYS------------------------------------------------------- --------------------------------------------------------ASGRE------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Mus_musculus_AKT3 -------------------------------------------------------------------------------- -------------------------------MSDVTIVKEG----WVQKRGEYIKNWRPRYFLLK---TDGSFIGYKEKP -QDVD-L-PYPLNNFSVAK------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CQLMKTER--PKPNTFIIR-CLQWTTVIERTFHVDTPEER-----------------------------E E-WTEAIQAVADRLQ----RQEEER--------MN-CSPTSQIDNIG--------------------------EEEMD-- -----ASTTHHKRK---------------------TMNDFDY--LKLLGKGTFGKVILVREKASG-------------KY YAMKILKKEVI-I--AKDEVAHTLTESR--VLKNTRHPFL-TSLKYSFQTKDRLCFVMEYVNGGEL------------FF HLSRE--------RVFSEDRTRFYGAEIVSALD-YLHSGK-IVYR---DLK--LENLMLDKDG--HIKITDFGLCKEGIT ------DAATMKTFCGTPE-YLAP--EVLEDNDYGRA-VDWWG---LGVVMYEMMCGRLPFY------NQDHEKLFELIL M--EDIKFPRT-LSSDAKSLLSGLLIK-DPNKRLGGGPDDA-----KEIMRHSFFSG---------VNWQDVYD------ --------KKLV---PPFKPQVT------------SETDTRYFDEEFTAQTITITPPEK---YDDDGMDG---------- ----------MDNERRPHFPQFSYS------------------------------------------------------- --------------------------------------------------------ASGRE------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Rattus_norvegicus_AKT3 -------------------------------------------------------------------------------- -------------------------------MSDVTIVKEG----WVQKRGEYIKNWRPRYFLLK---TDGSFIGYKEKP -QDVD-L-PYPLNNFSVAK------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CQLMKTER--PKPNTFIIR-CLQWTTVIERTFHVDTPEER-----------------------------E E-WTEAIQAVADRLQ----RQEEER--------MN-CSPTSQIDNIG--------------------------EEEMD-- -----ASTTHHKRK---------------------TMNDFDY--LKLLGKGTFGKVILVREKASG-------------KY YAMKILKKEVI-I--AKDEVAHTLTESR--VLKNTRHPFL-TSLKYSFQTKDRLCFVMEYVNGGEL------------FF HLSRE--------RVFSEDRTRFYGAEIVSALD-YLHSGK-IVYR---DLK--LENLMLDKDG--HIKITDFGLCKEGIT ------DAATMKTFCGTPE-YLAP--EVLEDNDYGRA-VDWWG---LGVVMYEMMCGRLPFY------NQDHEKLFELIL M--EDIKFPRT-LSSDAKSLLSGLLIK-DPNKRLGGGPDDA-----KEIMRHSFFSG---------VNWQDVYD------ --------KKLV---PPFKPQVT------------SETDTRYFDEEFTAQTITITPPEK---YDDDGMDC---------- ----------MDNERRPHFPQFSYS------------------------------------------------------- --------------------------------------------------------ASGRE------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Gallus_gallus_AKT3 -------------------------------------------------------------------------------- -------------------------------MSDVTIVKEG----WVQKRGEYIKNWRPRYFLLK---TDGSFIGYKEKP -QDVD-L-PYPLNNFSVAK------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CQLMKTER--PKPNTFIIR-CLQWTTVIERTFHVDTPEER-----------------------------E E-WTEAIQAVADRLQ----RQEEER--------MN-CSPTSQIDNIG--------------------------EEEMD-- -----ASTTHHKRK---------------------TMNDFDY--LKLLGKGTFGKVILVREKASG-------------KY YAMKILKKEVI-I--AKDEVAHTLTESR--VLKNTRHPFL-TSLKYSFQTKDRLCFVMEYVNGGEL------------FF HLSRE--------RVFSEDRTRFYGAEIVSALD-YLHSGK-IVYR---DLK--LENLMLDKDG--HIKITDFGLCKEGIT ------DAATMKTFCGTPE-YLAP--EVLEDNDYGRA-VDWWG---LGVVMYEMMCGRLPFY------NQDHEKLFELIL M--EDIKFPRT-LSADAKSLLSGLLIK-DPNKRLGGGPDDA-----KEIMRHSFFAG---------VNWQDVYD------ --------KKLV---PPFKPQVT------------SETDTRYFDEEFTAQTITITPPEK---YDEDGMDC---------- ----------MDNERRPHFPQFSYS------------------------------------------------------- --------------------------------------------------------ASGRE------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Danio_rerio_AKT3 -------------------------------------------------------------------------------- -------------------------------MNDLNVVKEG----WVQKRGEYIKNWRPRYFLLK---TDGSFIGYKEKP -QDAD-L-AYPLNNFSVAK------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CQLMKTER--PKPNTFIIR-CLQWTTVIERTFHVDTPEES-----------------------------R DEWVEAIQMVADKLA----KQEEEG--------IL-CSPISQIENVN--------------------------EEEMD-- -----TSTSHHKRK---------------------TMNDFDY--LKLLGKGTFGKVILVREKASG-------------TY YAMKILKKEVI-I--AKDEVAHTLTESR--VLKNTRHPFL-TSLKYSFQTKDRLCFVMEYVNGGEL------------FF HLSRE--------RVFSEDRTRFYGAEIVSALD-YLHSAK-IVYR---DLK--LENLMLDKDG--HIKITDFGLCKEGIT ------DAATMKTFCGTPE-YLAP--EVLEDNDYGRA-VDWWG---LGVVMYEMMCGRLPFY------NQDHEKLFELIL M--EEIKFPRT-LSADAKSLLSGLLIK-DPNKRLGGGPDDA-----KEIMRHSFFTA---------LDWQDVYD------ --------KKLV---PPFMPQVS------------SETDTRYFDEEFTAQTITITPPEK---YDEDGMDA---------- ----------ADSERRPHFPQFSYS------------------------------------------------------- --------------------------------------------------------ASGRE------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Takifugu_rubripes_AKT3a -------------------------------------------------------------------------------- ----------------------------------IYASSHLK----SSSLGEYIKNWRPRYFLLK---TDGSFIGYKEKP -QDAD-L-PYPLNNFSVAK------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CQLMKTER--PKPNTFIIR-CLQWTTVIERTFHVDSPDER-----------------------------D E-WTEAIQMVADKLQ----RQEEER--------IQ-CSPTSNIDNMV--------------------------EEEMD-- -----ISTTHHKRKV-------------------TTMSDFDY--LKLLGKGTFGKVILVREKASG-------------KY YAMKILKKEVI-I--AKDEVAHTLTESR--VLKNTRHPFL-TSLKYSFQTKDRLCFVMEYVNGGEL------------FF HLSRE--------RVFSEERTRFYGAEIVSALD-YLHSAK-IVYR---DLK--LENLMLDKDG--HMKITDFGLCKEGIT ------DAATMKTFCGTPE-YLAP--EVLEDNDYGRA-VDWWG---LGVVTYEMMCGRLPFY------NQDHEKLFELIL M--EDIKFPRT-LSSDAKSLLSGLLIK-DPNKRLGGGPDDA-----KEIMRHSFFSG---------IDWQDVYD------ --------KKLV---PPFKPQVT------------SETDTRYFDEEFTAQTITITPPEK---FDEDGMDC---------- ----------LDNERRPHFPQFSYS------------------------------------------------------- --------------------------------------------------------ASGRE------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Takifugu_rubripes_AKT3b -------------------------------------------------------------------------------- -------------------------------MSDQNVVKEG----WVQKRGEYIKNWRPRYFLLK---TDGSFIGYKDKP -QDSD-L-AYPLNNFSVAK------------------------------------------------------------- -------------------------------------------------------------------------------- ----------CQLMKTER--PKPNTFIIR-CLQWTTVIERTFHVDTPDER------------------------------ DEWAEAIQMVADSLA----KQEEEG--------IL-CSPISQIENVN--------------------------EEEMD-- -----TSISHYKRKF------------------VQTMNDFDY--LKLLGKGTFGKVILVKEKASG-------------TY YAMKILKKEVI-I--AKDEVAHTLTESR--VLKNTRHPFL-TSLKYSFQTKDRLCFVMEYVNGGEL------------FF HLSRE--------RVFSEDRTRFYGAEIVSALD-YLHSAK-IVYR---DLK--LENLMLDKDG--HIKITDFGLCKEGIT ------DTATMKTFCGTPE-YLAP--EVLEDNDYGRA-VDWWG---LGVVMYEMMCGRLPFY------NQDHEKLFELIL M--EEIKFPRT-LSADAKSLLSGLLIK-DPNKRLGGGPDDA-----KEIMRHSFFST---------IDWQDLYD------ --------KKLV---PPFQPQVS------------SETDTRYFDEEFTAQTITITPPEK---YDEDGMDA---------- ----------ADNERRPHFPQFSYS------------------------------------------------------- --------------------------------------------------------ASGRE------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------- >Tetraodon_nigroviridis_AKT3 -------------------------------------------------------------------------------- -------------------------------MSDQNVVKEG----WVQKRGEYIKNWRPRYFLLK---TDGSFIGYKDKP -QDSD-L-AYPLNNFSVAK------------------------------------------------------------- -------------------------