>Homo_sapiens_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MEPPGRRRGRAQPPLLLPLSLLALLALLGGGGGGGAAALPAGCKHDG---RPRGAGR-------AAG AAEGKVVCSSLEL-------AQVLPPDTLPNRT--VTLILSNNKISELKNGSF--------------------------- ---SGLSLLERLDLRNNLISSIDPGAFWGLSS---LKRL-DLTNNRIGCLNADIFRG-LTNLVRLNLSG----------- ------------------------------------NLFSSLSQGTFDYLA------------------------SLRSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTEYLLCDCNILWMHRWVKE-K NITVR-DTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGR------------IVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKR GNNTRTVDIVVLESS----------------------AQYCPPERVVNNKGD---FRWPRTLAGITAYLQCTRNTHGSGI YPGNP-----------QDERKAWRRCD--RGGFWADDDYSRCQYANDVTRVLYMFNQMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFTKEEKSK-ELGDVMVDIASNIMLADERVLWLAQ REAKACSRIVQCLQRIATYRLAGGA--------HVYSTYSPNIALEAYVIKST---GFTGMTCTVFQKVAASDRTGLS-D YGRR---DPEGNLDKQLSFKCNVSNTFSSLALKN---TIVEASIQLPPSLFSPKQ----KRELRPTDDSLYKLQLIAFRN GKLFPATG---NSTNLADDGKRRTVVTPVILTKID-GVNVDTHHIPVNVT----------------LRRIAHG----ADA VAARWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSELYTQ------------AASLLHP--VVYT TAIILLLCLLAVIVSYIYH-----HSLIRISLKSWHML--------------------VNLCFHIFLTCVVFVGGITQ-- ---TRNASICQAVGIILHYSTLATVLWVGVTAR----------------------------------NIYKQVTKKAKRC QDPDE-------PPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIKNYGSRP--NAPYCWMAWEPSLG------ -----------AFYGPASFITFVNCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKYELKE-------PTEEQQRLAANENGE----------------INHQDS-- ----------MSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYY-----PLDLVFSFVFG----ATSL SFSAFFVVHHCVNREDVRLAWIMT----------CCPGRSSYS----VQVNVQPPN-----------SNGTNGEAPK--- --------------------------------------------------------CPNSSAESSCTNKSASSFKNSSQ- GCKLTNLQAAAAQCHANS-------------------------------------LPLNSTPQLDNSLTEHSMDN----- ------------------DIKMHVAPLEVQFRT-------NVHSS-------RHHKNRSKGHRASRLTV----------- -----------------LREYAYDVPT---SVEG-SVQ---NGLPK---------------------------------- ------------------SRLGNNEGHSRSRR------AYLAYRERQYNPPQQ--------------------------- ------------------------------------DSSDACST-LPKSSR--------------NFEKPVSTTSKKDAL RKPAVVELENQQKSYGLNLAIQNG-PIKS----------NGQEGPLLGTDSTG---NVRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Gorilla_gorilla_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MEPPGRRRGRAQPPLLLQLSLLALLALLGGGGGGGAAALPAGCKHDG---RPRGAGR-------AAG AAEGKVVCSSLEL-------AQVLPPDTLPNRT--VTLILSNNKISELKNGSF--------------------------- ---SGLSLLERLDLRNNLISSIDPGAFWGLSS---LKRL-DLTNNRIGCLNADVFRG-LTNLVRLNLSG----------- ------------------------------------NLFSSLSQGTFDYLA------------------------SLRSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTEYLLCDCNILWMHRWVKE-K NITVR-DTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGR------------IVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKR GNNTRTVDIVVLESS----------------------AQYCPPERVVNNKGD---FRWPRTLAGITAYLQCTRNTHGSGI YPGNP-----------QDERKAWRRCD--RGGFWADDDYSRCQYANDVTRVLYMFNQMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFTKEEKSK-ELGDVMVDIASNIMLADERVLWLAQ REAKACSRIVQCLQRIATYRLAGGA--------HVYSTYSPNIALEAYVIKST---GFTGMTCTVFQKVAASDRTGLS-D YGRR---DPEGNLDKQLSFKCNVSNTFSSLALKN---TIVEASIQLPPSLFSPKQ----KRELRPTDDSLYKLQLIAFRN GKLFPATG---NSTNLADDGKRRTVVTPVILTKID-GVNVDTHHIPVNVT----------------LRRIAHG----ADA VAARWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSELYTQ------------AASLLHP--VVYT TAIILLLCLLAVIVSYIYH-----HSLIRISLKSWHML--------------------VNLCFHIFLTCVVFVGGITQ-- ---TRNASVCQAVGIILHYSTLATVLWVGVTAR----------------------------------NIYKQVTKKAKRC QDPDE-------PPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIKNYGSRP--NAPYCWMAWEPSLG------ -----------AFYGPASFITFVNCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKYELKE-------PTEEQQRLAANENGE----------------VNHQDS-- ----------MSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYY-----PLDLVFSFVFG----ATCL SFSAFFMVHHCVNREDVRLAWIMT----------CCPGRSSYS----VQVNVQPPN-----------SNGTNGEAPK--- --------------------------------------------------------CPNSSAESSCTNKSASSFKNSSQ- GCKLTNLQAAAAQCHANS-------------------------------------LPLNSTPQLDNSLTEHSMDN----- ------------------DIKMHVAPLEVQFRT-------NVHSS-------RHHKNRSKGHRASRLTV----------- -----------------LREYAYDVPT---SVEG-SVQ---NGLPK---------------------------------- ------------------SRLGNNEGHSRSRR------AYLAYRERQYNPPQQ--------------------------- ------------------------------------DSSDACST-LPKSSR--------------NFEKPVSTSSKKDAL RKPAVVELENQQKSYGLNLAIQNG-PIKS----------NGQEGPLLGTDSTG---NVRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Macaca_mulatta_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------MEPPGRRRGRAQPPLLLQLSLLALLALLGG--GGGAAALPAGCKHDG---RPRGSGR-------AAG AAEGKVVCSSLEL-------AQVLPPDTLPNRT--VTLTLFTNKITLK--GQD--------------------------- ---LDISLYETLDLRNNLISSIDPGAFWGLSS---LKRL-DLTNNRIGCLNADIFRG-LTNLVRLNLSG----------- ------------------------------------NLFSSLSQGTFDYLA------------------------SLRSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTEYLLCDCNILWMHRWVKE-R NITVR-DTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGR------------IVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKR GNNTRTVDIVVLESS----------------------AQYCPPERVVNNKGD---FRWPRTLAGITAYLQCTRNTHGSGI YPGNP-----------QDERKAWRRCD--RGGFWADDDYSRCQYANDVTRVLYMFNQMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFTKEEKSK-ELGDVMVDIASNIMLADERVLWLAQ REAKACSRIVQCLQRIATYRLAGGA--------HVYSTYSPNIALEAYVIKAT---GFTGMTCTVFQKVAASDRTGLS-D YGRR---DPDGNLDKQLSFKCNVSNTFSSLALKN---TIVEASIQLPPSLFSPKQ----KRELRPTDDSLYKLQLIAFRN GKLFPATG---NSTNLADDGKRRTVVTPVILTKID-GVNVDTHHIPVNVT----------------LRRIAHG----ADA VAARWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSELYTQ------------SASLLHP--VVYT TAIILLLCLLAVIVSYIYH-----HSLIRISLKSWHML--------------------VNLCFHIFLTCVVFVGGITQ-- ---TRNASVCQAVGIILHYSTLATVLWVGVTAR----------------------------------NIYKQVTKKAKRC QDPDE-------PPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIKNYGSRP--NAPYCWMAWEPSLG------ -----------AFYGPASFITFVNCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKYELKE-------PTEEQQRLAANENGE----------------INHQDS-- ----------MSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYY-----PLDLVFSFVFG----ATCL SFSAFFMVHHCVNREDVRLAWIMT----------CCPGRSSYS----VQVNVQPPN-----------SSGTNGEASK--- --------------------------------------------------------CANSSAESSCTNKSASSFKNSSQ- GCKLTNLQAAAAQCHANS-------------------------------------LPLNSTPQLDNSLTEHSMDN----- ------------------DIKMHVAPLEVQFRT-------NVHSS-------RHHKNRSKGHRASRLTV----------- -----------------LREYAYDVPT---SVEG-SVQ---NGLPK---------------------------------- ------------------SRLGNHEGHSRSRR------AYLAYRERQYNRPQQ--------------------------- ------------------------------------DSSDACST-LPKSSR--------------NFEKPVSTSSKKDAL RKPAVVELENQQKSYGLNLAIQNG-PIKS----------TGQEGSLLGTDSTG---NVRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Mus_musculus_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MEPPPPLLLLPLALLALLWGGERG-AAALPAGCKHDG---RARGTGR-------AAA AAEGKVVCSSLEL-------AQVLPPDTLPNRT--VTLILSNNKISELKNGSF--------------------------- ---SGLSLLERLDLRNNLISRIAPGAFWGLSS---LKRL-DLTNNRIGCLNADVFRG-LTNLVRLNLSG----------- ------------------------------------NLFTSLSQGTFDYLG------------------------SLRSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTEYLLCDCNILWMHRWVKE-R NITVR-DTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGR------------IVETDESQGIFVEKSMIHNCSLIASALTISNIQAGSTGNWGCHVQTKR GNNTRTVDIVVLESS----------------------AQYCPPERVVNNKGD---FRWPRTLAGITAYLQCTRNTHSSGI YPGSA-----------QDERKAWRRCD--RGGFWADDDYSRCQYANDVTRVLYMFNQMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFTREEKSK-ELGDVMVDVASNIMLADERVLWLAQ REAKACSRIVQCLQRIATHRLASGA--------HVYSTYSPNIALEAYVIKAA---GFTGMTCSVFQKVAASDRAGLS-D YGRR---DPDGNLDKQLSFKCNVSSTFSSLALKN---TIMEASIQLPSSLLSPKH----KREARAADDALYKLQLIAFRN GKLFPATG---NSTKLADDGKRRTVVTPVILTKID-GATVDTHHIPVNVT----------------LRRIAHG----ADA VAAQWDFDLLNGQGGWKSDGCCILYSDENITTIQCGSLGNYAVLMDLTGTELYTP------------AASLLHP--VVYT TAITLLLCLLAVIISYMYH-----HSLIRISLKSWHML--------------------VNLCFHILLTCVVFVGGITQ-- ---TRNASVCQAVGIILHYSTLATVLWVGVTAR----------------------------------NIYKQVTKKAKRC QDPDE-------PPAPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIKNYGSRP--SAPYCWMAWEPSLG------ -----------AFYGPASFITFVNCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKYELKE-------PTEEQQRLAANENGE----------------INHQDS-- ----------MSLSLISTSTLENEHSFQSQLLGASLTLLLYVILWMFGAMAVSLYY-----PLDLVFSFFFG----ATCL SFSAFMMVHHCINREDVRLAWIMM----------CCPGRSSYS----VQVNVQPPN-----------SSATNGEAPK--- --------------------------------------------------------CTNSSAESSCTNKSASSFKNSSQ- GCKLTNLQAAAAQYHSNA-------------------------------------LPVNATPQLDNSLTEHSMDN----- ------------------DIKMHVAPLDVQFRT-------NVHPS-------RHHKNRSKGHRASRLTV----------- -----------------LREYAYDVPT---SVEG-SVQ---NGLPK---------------------------------- ------------------SRPGSNEGHSRSRR------AYLAYRERQYNPPQQ--------------------------- ------------------------------------DSSDACST-LPKSSR--------------NVEKPVSTSSKKDAP RKPAAADLESQQKSYGLNLAVQNG-PVKS----------NGQEGPLLATDVTG---NVRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Rattus_norvegicus_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MERPP--LLLPLALLALLWGGERG-AVALPAGCKHDG---RARGTGR-------AAG -AEGKVVCSSLEL-------AQVLP-DTLPNRT--VTLILSNNKISELKNGSF--------------------------- ---SGLSLLERLDLRNNLISRIAPGAFWGLSS---LKRL-DLTNNRIGCLNADVFRG-LTNLVRLNLSG----------- ------------------------------------NLFTSLSQGTFDYLG------------------------SLRSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTEYLLCDCNILWMHRWVKE-R NITVR-DTRCVYPKSLQAQPVTGVKQELLTCGPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGR------------IVETDESQGIFVEKSMIHNCSLIASALTISNIQAGSTGNWGCHIQTKR GNNTRTVDIVVLESS----------------------AQYCPPERVVNNKGD---FRFNKTLCVCVCVCVCVQGYSFSSF KEGVK-----------HSQQNLTLEFE--R----LFDNWFRCGEWVNSVSINSPFGLMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFTKEEKSK-ELGDVMVDVASNIMLADERVLWLAQ REAKACSRIVQCLQRIATHRLASGA--------HVYSTYSPNIALEAYVIKAA---GFTGMTCSVFQKVAASDRTGLS-D YGRR---DPDGNLDKQLSFKCNVSSTFSSLALKN---TIMEASIQLPSSLFSPKQ----KREVRATDDSLYKLQLIAFRN GKLFPATG---NSTKLADDGKRRTVVTPVILTKID-GVTTDTHHVPVNVT----------------LRRIAHG----ADA IAAQWDFDLLNGQGGWKSDGCCILYSDENITTIQCGSLGNYAVLMDLTGSELYTP------------AASLLHP--VVYT TAITLLLCLLAVIISYMYH-----HSLIRISLKSWHML--------------------VNLCFHIFLTCVVFVGGITQ-- ---TRNASVCQAVGIILHYSTLATVLWVGVTAR----------------------------------NIYKQVTKKAKRC QDPDE-------PPAPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIKNYGSRP--SAPYCWMAWEPSLG------ -----------AFYGPASFITFVNCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKYELKE-------PAEEQQRLAANENGE----------------INPQDS-- ----------MSLSLISTSTLENEHSFQSQLLGASLTLLLYITLWMFGAMAVSLDY-----PLDLVFSFFFG----ASCL SFSAFIMVHHCINREDVRLSWIMM----------CCPGRGSYS----VQVNVQPPT-----------SSAANGEAPK--- --------------------------------------------------------CTNSSAESSCTNKSASSFKNSSQ- GCKLTNLQAAAAQYHSNA-------------------------------------LPVSATPQLDNSLTEHSMDN----- ------------------DIKMHVAPLDVQFRA-------NMHPS-------RHHKNRSKGHRASRLTV----------- -----------------LREYAYDVPT---SVEG-SGQ---SGSPK---------------------------------- ------------------SRPGSSEGHSRSRR------AYLAYRERQCNPPQQ--------------------------- ------------------------------------DSSDAGST-LPKSGR--------------NVEKPLSTSSKKDAP RKPAAADLESQQKSYGLNLAVQNG-PVKS----------NGQEGPLLATDITG---NIRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Felis_catus_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------METASEEAEKPLQ--GFRILSNNKISELKNGSF--------------------------- ---SGLSLLERLDLRNNLISSIDPGAFWGLSS---LKRL-DLTNNRIGCLNADIFRG-LTNLVRLNLSG----------- ------------------------------------NLFSSLSQGTFDYLG------------------------SLRSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTEYLLCDCNILWMHRWVKE-R NITVR-DTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGR------------IVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKR GNNTRTVDIVVLESS----------------------AQYCPPERVVNNKGD---FRWPRTLAGITAYLQCTRNIHGSGI YPGNP-----------QDERKAWRRCD--RGGFWADDDYSRCQYANDVTRVLYMFNQMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFTKEEKSK-ELGDVMVDIASNIMLADERVLWLAQ REAKACSRIVQCLQRIATYRLANGA--------HVYSTYSPNIALEAYVIKAA---GFTGMTCTVFQKVAASDRTGLS-E YGRR---DPDGNLDKQLSFKCNVSNTFSSLALKN---TIVEASIQLPPSLFSPKQ----KREVRPTDDSLYKLQLLAFRN GKLFPATG---NSTNLADDGKRRTVVTPVILTKID-GVNVDTHHIPVNVT----------------LRRIAHG----ADA VAAQWDFDLLNGQGGWKSDGCYILYSDENITTMQCNSLSNYAVLMDLTGSELYTQ------------AASLLHP--VVYT TAVILLLSLLAVIVSYIYH-----RSLIRISLKGWHML--------------------VNLCFHIFLTCVVFVGGVTQ-- ---TRNASICQAIGIILHYSTLATVLWVGVTAR----------------------------------NIYKQVTRKAKRC QDPDE-------LPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIKNYGSRP--HAPYCWMAWEPSLG------ -----------AFYGPASFITFVNCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKYELKE-------PTEEQQRLAANENGE----------------VNHQDS-- ----------LSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYY-----PLDLVFSFFFG----ATCL SLSAFIVVHHCVNREDVRLAWIMT----------CCPGRSSYS----VQVNVQPPS-----------SSGANGEAPK--- --------------------------------------------------------CTNSSAESSCTNKSTSSFKNSSQ- GCKLTNLQAAAAQCHTNS-------------------------------------LPLNSTPQLDNSLTEHSMDN----- ------------------DIKMHVAPLEVQCRT-------NVHPS-------RHHKNRSKGHRASRLTV----------- -----------------LREYAYDVPT---SVEG-SVQ---NGLPK---------------------------------- ------------------SRPGNNEGHSRSRR------AYLAYRERQYNPPQP--------------------------- ------------------------------------DSSDGCST-LPKSGR--------------NFEKPISNSSKKDAL RKPIVVELESQQKSYGLNLAIQNG-PIKS----------SGQEGPLLGTDSTG---NVRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Bos_taurus_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------ILSNNKISELKNGSF--------------------------- ---SGLSLLERLDLRNNLISSIDPGAFWGLSS---LKRL-DLTNNRIGCLNADIFRG-LTNLVRLNLSG----------- ------------------------------------NLFSSLSQGTFDYLG------------------------SLRSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTEYLLCDCNILWMHRWVKE-R NITVR-DTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGR------------IVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKR GNNTRTVDIVVLESS----------------------AQYCPPERVVNNKGD---FRWPRTLAGITAYLQCTRNAHGSGI YPGNA-----------QDERKAWRRCD--RGGFWADDDYSRCQYANDVTRVLYMFNQMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFTKEEKSK-ELGDVMVDIASNIMLADERVLGLAQ REAKACSRIVQCLQRIATYRLANGA--------HVYSTYSPNIALEAYVIKAT---GFTGMTCTVFQKVAATDRTGLS-D YGRR---DLDGNLDKQLSFKCNVSNTFSSLALKN---TIVEASIQLPPSLFSPKQ----KREVRPSDDSLYKLQLIAFRN GKLFPATG---NSTNLADDGKRRTVVTPVILTKID-GVNIDTHHIPVNVT----------------LRRIAHG----ADA VAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSEFYTQ------------AAHLLHP--VVYT TAVILLLCLLAVIVSYIYH-----HSLIRISLKGWHML--------------------VNLCFHIFLTCVVFVGGISQ-- ---TRNASVCQAVGIILHYSTLATVLWVGVTAR----------------------------------NIYKQVTKKAKRC QDPDE-------LPPPPRPMLRFYLIG-GGIPVIVCGITAAA-------NIKNYGSRP--NAPYCWMAWEPSLG------ -----------AFYGPASFITFVNCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKYELKE-------PTEEQQRLAANENGE----------------VNHQDS-- ----------MSQSLISTSALGNEHTFHAQLLGASLTLLLYVGLWMFGALAVSLYY-----PLDLVFSFFFG----ATCL SLSAFIVVHHCVNREDVRLAWIMT----------CCPGRSTYS----VQVNVQPPS-----------SSGPSGEAPK--- --------------------------------------------------------CTNSSAESSCTNKSASSFKNSSQ- GCKLTNLQAAAAQCHTNS-------------------------------------LPLNATPQLDNSLTEHSMDN----- ------------------DIKMHVAPLEVPFRT-------NMHPS-------RHHKNRSKGHRASRLTV----------- -----------------LREYAYDVPT---SVEG-SVQ---NGLPK---------------------------------- ------------------SRLGSNEGHSRSRR------AYLAYRERQYNPPQQ--------------------------- ------------------------------------DSSDACST-LPKSSR--------------NFEKPVSTSSKKDAV RKPTVVELESQQKSYGLNLAIQNG-PIKS----------SGQEGPLLGTDSTG---NVRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Equus_caballus_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------ILSNNKISELKNGSF--------------------------- ---SGLSLLERLDLRNNLISSIDPGAFWGLSS---LKRL-DLTNNRIGCLNADVFRG-LTNLVRLNLSG----------- ------------------------------------NLFSSLSQGTFDYLG------------------------SLRSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTEYLLCDCNILWMHRWVKE-R NITVR-DTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGR------------IVETDESQGIFVEKSMIHNCSLIASALTISNIQAGSTGNWGCHVQTKR GNNTRTVDIVVLESS----------------------AQYCPPERVVNNKGD---FRWPRTLAGITAYLQCTRNTHGAGI YPGNP-----------QDERKAWRRCD--RGGFWADDDYSRCQYANDVTRVLYMFNQMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFTKEEKSK-ELGDVMVDIASNIMLADERVLWLAQ REAKACSRIVQCLQRIATYRLANGA--------HVYSTVRLPSCQYPLSVLAN---TLFCALKDVLREYLIACRISVS-K ED-W---DAPQNLVNLLTFSCNVSNTFSSLAAKEN--TIVEASIQLPPSLFSSKQ----KREVRPTDDSLYKLQLIAFRN GKLFPATG---NSTNLADDGKRRTVVTPVILTKID-GVNVDTHHIPVNVT----------------LRRIAHG----ADA VAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSELYTQ------------AASLLHP--VVYT TSIILLLCLLAVIVSYIYH-----HSLIRISLKGWHML--------------------VNLCFHIFLTCVVFVGGITQ-- ---TRNASVCQAVGIILHYSTLATVLWVGVTAR----------------------------------NIYKQVTKKTKRC QDPDE-------LPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIKNYGSRP--NAPYCWMAWEPSLG------ -----------AFYGPASFITFVNCMYFLSI------------------------------------------------- ------------------FIQLRRHPERKYELKE-------PTEEQQRLAANEHGE----------------VNHQDS-- ----------MSLSLISTSALENEHTFHSQLMGASLTLLLYVTLWMFGALAVSLYY-----PLDLVFSFFFG----ATCL SLSAFIMVHHCVNREDVRLAWIMT----------CCPGRSSYS----VQVNVQPPN-----------SSGTNGEAAK--- --------------------------------------------------------CTNSSAESSCTNKSASSFKNSSQ- GCKLTNLQAAAAQCHTNS-------------------------------------LPLNATPQLDNSLTEHSMDN----- ------------------DIKMHVAPLEVQFRT-------NVHPS-------RHHKNRSKGHRASRLTV----------- -----------------LREYAYDVPT---SVEG-SVQ---NGLPK---------------------------------- ------------------SRPGNTEGHSRSRR------AYLAYRERQYNPPQQ--------------------------- ------------------------------------DSSDACST-LPKSSR--------------NFEKPVSTSSKKDTL RKPIVVELESQQKSYGLNLAIQNG-PIKS----------NGQDGPLLGTDSTG---NVRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Loxodonta_africana_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------ALFALLGGSGCAAALPPGCKQDG---RPRGTGR-------AAG AAEGKVVCSSLEL-------AQVLPPDTLPNRT--VTLILSNNKISELKNGSF--------------------------- ---SGLSLLERLDLRNNLISSIDPGAFWGLSS---LKRL-DLTNNRIGCLNADIFRG-LTNLVRLNLSG----------- ------------------------------------NLFSSLSQGTFDYLG------------------------SLRSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTEYLLCDCNILWMHRWVKE-R NITVR-DTRCAYPKSLQAQPVTGVKQELLTCDAPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWSQDGR------------IVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKR GNNTRTVDIVVLESS----------------------AQYCPPERVVNNKGD---FRWPRTLAGITAYLQCTRNTHGSGI YPGSP-----------QDERKAWRRCD--RGGFWADDDYSRCQYANDVTRVLYMFNQMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFTKEEKSK-ELGDVMVDIASNIMLADERVLWLAQ REAKACSRIVQCLQRIATYRLANGA--------HVYSTSSPNIALEAYVIKAA---GFTGMTCTVFQKVATSDRTGLS-D YGRR---DLDGNLDKQLSFKCNISNTFSSLALKN---TIVEATIQLPSSLFSPKQ----KREVRPTDDSLYRLQLIAFRN GKLFPATG---NSTNLADDGKRRTVVTPVILTKID-GVNVDTHPIPVNVT----------------LRRIAHG----ADA VAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCHSLSNYAVLMDLTGSELYTQ------------AADLLHP--VIYT TAIILLLCLLAVIVSYIYH-----HSLIRISLKSWHML--------------------VNLCFHVFLTCVVFVGGVTQ-- ---TRNVSICQAVGIILHYSTLATVLWVGVTAR----------------------------------NIYKQVTKKAKRC QDPDE-------PPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIKNYGSRP--NAPYCWMAWEPSLG------ -----------AFYGPASFITFVNCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKYELKE-------PTEEQQRLAANENGE----------------VTHQDS-- ----------MSLSLISTSVLENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYY-----PLDLVFSFFFG----ATCL SFSAFIMVHHCVNREDVRLAWIMT----------CCPGRSSYS----VQVNVQPPS-----------SSGTNGEAPK--- --------------------------------------------------------CTNSSAESSCTNKSASSFKNSSQ- GCKLTNLQAAAAQCHTTS-------------------------------------LPLNSVPQLDNSLTEHSMDN----- ------------------DIKMHVAPLEVQFRT-------NMHPG-------RHHKNRSKGHRASRLTV----------- -----------------LREYAYDVPT---SVEG-SVQ---NGLPK---------------------------------- ------------------SRPGNNEGHSRSRR------AYLAYRERQYNPPQQ--------------------------- ------------------------------------DSSDACST-LPKSSR--------------NFEKPVSTSSKKDAS RKPIVVELESQQKSYGLNLAIQNG-PIKS----------NGQDGPLLSTDSTG---NVRTGLWRHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Dasypus_novemcinctus_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------------------------------------------------MHRWVKE-R NITVR-DTRCAYPKSLQAQPVTGVRQELLTCDPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGR------------IVETDEAQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKR GNNTRTVDIVVLESS----------------------AQYCPPERVVNNKGD---FRWPRTLAGITAYLQCTRSNHGSGI YPGNP-----------QDERKAWRRCD--RGGFWADDDYSRCQYANDVTRVLYMFNQMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFTKEEKSK-ELGDVMVDIASNIMLADERVLWLAQ KEAKACSRIVQCLQRIATYRLANGA--------HVYSTYSPNIALEAYVIKAT---GFTGMTCTVFQKVAASDRTGLS-D YGRR---DPDGNLDKQLSFKCNVSNTFSSLALKN---TIIEASIQLPPSLFSPKQ----KREVRPTDDSLYKLQLIAFRN GKLFPATG---NSTNLADDGKRRTVVTPVILTKID-GVNADTHPIPVNVT----------------LRRIAHG----ADA VAAQWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSELYTQ------------AAVLLHP--VVYT TAVILLLCLLAVIVSYIYH-----HSLIRISLKSWHML--------------------VNLCFHIFLTCVVFVGGITQ-- ---TRNASVCQAVGIILHYSTLATVLWVGVTAR----------------------------------NIYKQVTKKAKSC QDPDE-------PPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIKNYGSRP--HAPYCWMAWEPSLG------ -----------AFYGPASFITFVNCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKYELKE-------PTEEQQRLAVNENGE----------------INHQDS-- ----------MSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYY-----PLDLVFSFFFG----ATCL SFSAFLMVHHCINREDVRLAWIMT----------CCPGRSSYS----VQVNIQPPS-----------SSGTNGEPPK--- --------------------------------------------------------CTNSSAESSCTNKSASSFKNSSQ- GCKLTNLQAAAAQCHASS-------------------------------------LPLNSMPQLDNSLTEHSMDN----- ------------------DIKMHVAPLEVQFRT-------NVHPS-------RHHKNRSKGHRASRLTV----------- -----------------LREYAYDVPT---SVEG-SVQ---NGLPK---------------------------------- ------------------SRPGSNEGHSRSRK------AYLAYRERQYNPPQQ--------------------------- ------------------------------------DSSDACST-LPKSSR--------------NFEKPVSTSSKKDAL RKPIAAELESQQKSYGLNLAIQNG-PIKS----------NGQDGPLLGTDSTG---NVRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Gallus_gallus_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MLPPLRRAPCRPLRPRARRPARLLAALLLLAALRGGGTALPPGCKYDG---RPKSSGK-----AAAGG PLEVKVVCSNLEL-------AHVLPPEALPNRT--VTLILSNNRITELKNCSF--------------------------- ---SGLNLLERLDLKNNLISTIDPGAFLGLSS---LKRL-DLTNNRIGCLNADVFKG-LVNLIRLNLSG----------- ------------------------------------NLFSTLTQGTFDHLG------------------------SLKSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTDYLLCDCNILWMHQWLKE-R NITVR-ETKCAYPKSLQSQTVTGVKQELLTCEPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGK------------IVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTRR GNNTRTVDIVVLESS----------------------AQYCPPERVVNNKGD---FRWPRTLAGITAYLLCTRYSAGSGI YPGNS-----------QDERRAWRRCD--RGGYWAEEDYSRCQYANDVTRVLYMFNQMPLN------------------- ----LTNALATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFA--EKYK-ELGDVMVDIASNIMLADERVLWMAQ RESKACTRIVQCLQKIAMYRLANGA--------QVYSTYSPNIALEAYVIKAA---GFTGMTCTVFQKVATSDRTGLS-D YGRR---DPDGNLDKQLSFKCNVSNTLSSLALKN---TIIEASIQLPASLFTQKQ----KREIRPADESVYKLQLIAFRN GKLFPATG---NSTNLADDGKRRTVVTPVILTKID-GLNPASHHVPINVT----------------LRRIAHG----ADA VAAQWDFDLLNGQGGWKSDGCRILLSDENITTIQCYSLSNYAVLMDLTEAELYTQ------------PADLLHP--VIYA TAMVLLMCLLMIIVSYIYH-----HSVIRISVKSWHML--------------------VNLSFHIFLTCVMFIGGITQ-- ---TRNASICQAVGIILHYSTLATVLWLGVTSR----------------------------------NIYKQVTKKAKRC QDTDE-------PPPPPRPMLRFYLIG-GGIPVIVCGITAAA-------NIRNYGSRP--NAPYCWMAWEPSLG------ -----------AFYGPASFIIFINCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKYELKE-------PAEEQQRLATNEHGE----------------LTHQDS-- ----------LSVSLVSTSALENEHSFQAQLMGVSLTLLLYIALWIFGALSVSLYY-----PMDLIFSCFFG----ATCL SLSAFLMVHHCVNREDVRHAWITT----------CCPGRSTYS----VQVNVQPSS-----------SSGTNGETPK--- --------------------------------------------------------CTNSSAESSCTNKSAASLKNSSQ- GCKLTNLQAAAAQCHSTS-------------------------------------LPLNTGPQLDNSLTEHSVDN----- ------------------DIKMHVAPLEVQFRT-------NGHPS-------RHHKNRSKGHRASRLAV----------- -----------------LREYAYDVPT---SVEG-SVQ---NGVPK---------------------------------- ------------------SRPSNSEGHSRSRR------AYLAYRERQYNQSQQ--------------------------- ------------------------------------DSSDACST-LPKSSR--------------NTEKAIAANNKKEIL RKPIVVELENQQKSYGLNLAIQNG-PLKS----------SGQDGPLLTADSTG---NIRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Taeniopygia_guttata_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------------------------------XPPGCKYDG---RPKSAGK-----AAAGG PAEVKVVCSNLEL-------AQVLPPEALPNRT--VTLILSNNKITELKNGSF--------------------------- ---SGLHLLERLDLKNNLISTIDPGAFLGLSS---LKRL-DLTNNRIGCLNADIFRG-LVNLIRLNLSG----------- ------------------------------------NLFSTLTQGTFDHLG------------------------SLKSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTDYLLCDCNILWMHQWLKE-R NITVR-ETKCAYPKSLQSQTVTGVKQELLTCEPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGK------------IVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTRR GNNTRTVDIVVLESS----------------------AQYCPPERVVNNKGD---FRWPRTLAGITAYLLCTRYSAGSGI YPGNS-----------QDERRAWRRCD--RGGYWADEDYSRCQYANDVTRVLYMFNQMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFA--EKYK-ELGDVMVDIASNIMLADERVLWMAQ REAKACTRIVQCLQKIAMYRLANGA--------QVYSTYSPNIALEAYVIKAA---GFTGMTCTVFQKVATSDRTGLS-D YGRR---DPDGNLDKQLSFKCNVSNTLSSLALKN---TIVEASIQLPASLFTQKQ----KREIRPADESVYKLQLIAFRN GKLFPATG---NSTNLADDGKRRTVVTPVILTKID-GLSIASHHVPINVT----------------LRRIAHG----ADA VAAQWDFDLLNGQGGWKSDGCRILLSDENITTIQCYSLSNYAVLMDLTGAELYTQ------------PADLLHP--VIYA TAMVLLMCLLMIMVSYIYH-----HSVIRISVKSWHML--------------------VNLSFHIFLTCIVFIGGITQ-- ---TRNASICQAVGIILHYSTLATVLWLGVTSR----------------------------------NIYKQVTKKAKRC QDPDE-------PPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIRNYGSRP--NAPYCWMAWEPSLG------ -----------AFYGPASFIIFINCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKYELKE-------PVEEQQRLATNEHGE----------------LAHQDS-- ----------LSVSLVSTSALENEHSFPAQLLGVGLTLVLYVTLWIFGALSISLYY-----PMDLIFSCFFG----ATCL SLSAFLMVHHCINREDVRHAWITT----------CCPGRSTYS----VQVNVPPSS-----------SSGTNGEAPK--- --------------------------------------------------------CTNSSAESSCTNKSASSLKNLSQ- GCKLTNLQAAAAQCHPTS-------------------------------------LPLNTGPQLDNSLTEHSVDN----- ------------------DIKMHVAPLEVQFRT-------NGHPS-------RHHKNRSKGHRASRLAV----------- -----------------LREYAYDVPT---SVEG-SVQ---NGLPK---------------------------------- ------------------TRPSNSEGHSRSRR------AYLAYRERQYNQSQQ--------------------------- ------------------------------------ESSDACST-LPKSSR--------------NTEKTIATSNKKDIL KKPITAELENQQKSYGLNLAIQNG-PLKS----------SGQDGPLLTADSTG---NIRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Anolis_carolinensis_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MAAPPSGRLLLLLFLALVEGGPGLPLGCKQDGPGGRPRSGKAGPL--SPSEA GGGGKVVCTSLDL-------AHVLAPGALPNGT--VALILSNNKIAGLKNGSF--------------------------- ---SGLSLLERLDLKNNLISVIDPGAFMGLTS---LKRL-DLANNQIGCLNVDMFKG-LANLVRLNLSG----------- ------------------------------------NLFSSLAQGTFDHLT------------------------SLKSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTDYLLCDCNMLWMQQWVQE-R NITVR-DTRCAYPKSLQAQPVLGVKQGLLTCGPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGK------------IVETDESQGIFIEKSMIHNCSLIASALTISNIQAGSTGNWGCHVHTRR GNNSRTVDIVVLNSS----------------------AQYCPPERVVNNKGD---FRWPRTLAGITAYLLCTRYSAGSGI YPGNS-----------QDEKRAWRRCD--RGGFWAEEDYSRCQYANDATRVLYMFNQMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFA--EKYK-ELGDVMVDIASNIILADEHILWMAQ REAKACTRIVQCLQRIATYRLANGA--------QVYSTYSPNIAVEAYVIKSS---GFTGMTCTVFQKVAATDRIGLP-D YGRR---DLDGGLDKQLGFKCNVSNTLSSLALKN---TIVEASIQLPPALFSKKH----KREIKPVDDTAYKLQLIAFRN GKLFPTTG---NSTTLAAESKRLSVVTPVILTKID-GLNIPHPDIPINVT----------------LRRIANG----AHA VAVQWDFDLLNGQGGWKSDGCHILSSDENVTTIQCYSLSNYAVLMDLSG---HIQ------------SLDSLHP--VIYV SAVVLLICLLVIKVTYIYH-----HSVIKISLKSWHML--------------------VNLSFHIFLTCVMFIGGITQ-- ---SKNASICQAVGIILHYSTLASLLWMGVTSR----------------------------------NIYKQVTKKSKRC QDPDE-------PPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIRNYGSRP--HSAYCWMTWEPSLG------ -----------AFYGPAGFIIFINCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKFELKE-------PTEEQQRLASNEHGT----------------LNHQDS-- ----------MSVSLVSTSALENEHSFHAQLLGVSLTLFLYVTLWILGAFSVSFSY-----PLDLVFSCFFA----AICL SLSGFLLTQHCINREDVKHAWMTA----------CCPGRSTYS----VQVNIQPSSS----------ASGANGESAK--- --------------------------------------------------------CTNSSAESSCTSKSVASLKNSSQ- ACKLTNIQAAAAQCPPAS-------------------------------------LAPNTGATLDNSLTEHSVDN----- ------------------EIKMHVAPLEVPLRT-------NGHPG-------RHHKNRSKGHRSSRLAV----------- -----------------LREYAYDVPT---SVEG-SIQ---NGLTK---------------------------------- ------------------SRQSVSEGHSRSRR------AYLAYRERQYTQSQQ--------------------------- ------------------------------------DSSDACST-LHKGHW--------------NTEKSVPTNLKKDVL RKPTVEDLEGQQKSYGLNLAVQNG-PLKN----------STQDGMLLSADSTG---NIRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Pelodiscus_sinensis_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------MPGPGRCPSPWPLLFLALLGGASLPPGCKLDG---RPKSPGR-----SPAEG ----KVVCSSLEL-------ARVLPPDALPNRT--VTLILSNNKILELKNGSF--------------------------- ---SGLSLLERLDLKNNLISIINPGAFMGLPS---LKRL-DLSNNKIGCLNAEMFRG-LINLVRLNLSG----------- ------------------------------------NLFSSLTQGTLDHLN------------------------SLKSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTDYLLCDCNILWMPQWLKE-R NITVR-ETKCAYPKSLQSQLVTSVKQELLTCEPPLELPSFYMTPSHRQVVFEGDSLP---FQCMASYIDQ---------- ---------DMQVLWYQDGK------------IVETDESQGIFVEKNIIHNCSLIASALTISNIQAGSTGNWGCHVQTRR GNNTRTVDIVVLESS----------------------AQYCLPERVVNNKGD---FRWPRTLAGITAYLLCTRYSAGSGI YPGNS-----------QDERRAWRRCD--RGGFWAEEDYSRCQYANDVTRVLYMFNQMPLN------------------- ----LTNAVATARQLLAYTVEAANF---SDKMDVIFVAEMIEKFGRFA--EKYK-ELGDVMVDIASNIMLADERVLWMSQ REAKACTRIVQCLQRIAMYRLANGA--------QVYSTYSPNIALEAYVIKAA---GFTGMTCTVFQKVATSDRIGLS-D YGRR---DPDGNLDKQLSFKCNVSNTLSSLALKN---TIVEASIQLPPSLFTQKQ----KREIRPANESIFKLQLIAFRN GKLFPATG---NSTNLADNGKRRTVVTPVILTKID-GLSLASHHIAINVT----------------LRRIAHG----ADA VAAQWDFDLLNGQGGWKSDGCHIISSDENITTIQCYSLSNYAVLMDLAGGELYTE------------PPVLLHP--VIYA TSVVLLMCLLMIIVSYIYH-----HSVIRISVKSWHML--------------------VNLSFHIFLTCVMFIGGITQ-- ---TKSTSVCQAVGIILHYSTLATVLWLGVTSR----------------------------------NIYKQVTKKAKRC QDPDE-------PPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIRNYGSRP--TTPFCWMTWEPSLG------ -----------AFYGPASFIIFINCMYFLSI------------------------------------------------- ------------------FIQLKRHPERKFELKE-------QAEEQQRLATNEHGE----------------LNHQDS-- ----------VSVSLVSTSALENEHSFQAQLLGASLTLFLYVTLWIFGALAVSLYY-----PMDLILSCFFG----ATCL SLSAFLMMHHCVNREDVRHAWITA----------CCPGRSTYS----VQVNVQPSN-----------SSGTNGETPK--- --------------------------------------------------------CTNSSAESSCTNKSASSLKNSSQ- SCKLTNIQAAAAQCHPTS-------------------------------------LPLNTGPQLDNSLTEHSVDN----- ------------------DIKMHVAPLEIQFRT-------NGHQS-------RPHKNRSKGHRASRLTV----------- -----------------LREYAYDVPT---SVEG-SVQ---NGLSK---------------------------------- ------------------SRQSNSEGYSRSRR------AYLAYRERQYSQSQQ--------------------------- ------------------------------------DSSDACST-LPKSNK--------------NTEKSIAANNKKEVL RKPIVVELESQQKSYGLNLAIQNG-QLKG----------SGQDGPLITADSTG---NIRTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Danio_rerio_GPR125_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------ILSNNKIQELLNGSF--------------------------- ---VGLSSLERLDIKNNIITHIEPGAFYGLFS---LKRLKDLSKNLIGCLHVDVFKG-LTNLVKLNLSE----------- ------------------------------------NKFSSLSQGIFDSLG------------------------SLKIL -------------------------------------------------------------------------------- --------------------------------------------------------EFDSPYLLCDCNLQWLVVWIKE-K AIGVK-ETRCSFPRSLQGQLITTLRAETLTCDAPLELPSFQMTPSQHQIVFQGDSLP---FQCMASFVDE---------- ---------DMQVLWYQDGK------------MVEPDATQGIYIEKSMVQNCSLIASALTISNIQPGFTGNWECRVRTSR GNNTRTVHIVVLESS----------------------AKYCLPDRVSNNKGE---YSLALHYTLVAFYLHCNYLSNYWVI CHFYP-----------EAFDRTLKYTTENRSTFSTGNTCSESAVIHRPSYYLVQFYLPPIF------------------- ----HDGRAIVFRNSAAMSLRSSNT---RTVISFYFFQNNCRQKTQFFSAPVAF-SLGDVMVDISSNLLLADERVLWMAQ REARACSRMVESLQRIALLRVSNG----------ALAYSTVSIEKNPH-VRQT---LWN--------------------- ----------------FCFKR------------T---VQAVRYFQLSPAFLN------------------INLNIITYRN GKLFPPTG---NSSILSDGSKRRSVVTPVMITKIE-GFPLRDLLSPVNVT----------------LRRFLQG----SDA VPAFWNFSLQGGQGGWQSDGCRILHQDDNFTTVSCHSLNSYAVLMDLNRTGYNVF------------IFRPLHP--VIYS TALVLVLCLLSVIVSYIYH-----HKSVRISKKCWHML--------------------VNLCLHILLTCAVFVGGINQ-- ---TYNASVCQAMGIVLHYSTLATALWSGVTAR----------------------------------NIYKQVTRKAKRY EELDE-------PPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIKNYGSQV--NAPYCWMAWEPSLG------ -----------AFYGPAAFIVFVDCMYFLSI------------------------------------------------- ------------------LIQLRRHPERRFELKE-------QSEEQQHLSVTEATEITP-------------VHLESS-- ----------PTAQPVPMSALENEHTFVSQLMGVAGSLTLYAALWVFGALAISQEH-----PADLVFACLFG----ALAL GLGAFLVAHHCVNRQDMRRHWSQA----------CCLIRRNYA----VQG-----SSGSVMT------SRGNGEATK--- --------------------------------------------------------CPASSAESSCTNKSAPSLRNSTQ- GCKLTNLQVEAAQCKVVAP------------------------------------STANGTAVLDNSLTEHSVDN----- ------------------EIKMHVAPIEIQYRPSNAN--ITGHPG-------RHHKNRSRAHRASRLTV----------- -----------------LREYSYDVPT---SVEG-SVQ----SVPN---------------------------------- ------------------KRHHHESLHARNSRR----AAYLAYRERQQSQLQQ--------------------------- ------------------------------------DSSDAASTSVPRRSR--------------HFSKADVTNQTKECP KQTLTVELEVQPKSYGLNLACQNGSAKDS----------ER-----LNVESSG---NVKTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Takifugu_rubripes_GPR125_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----KVVCSNMEL-------HQVLPADSFPNRT--VTLILNNNKIQELRNGSF--------------------------- ---FGLSALEKLDLRSNLISSVEPGAFLGLAA---LKRL-DLSNNSIGCLNVDVFKG-LASLMRLNLSG----------- ------------------------------------NVFSTIAPGTFDSLV------------------------SLKSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTAFLLCDCNLLWLLRWIKE-R SVAVK-STKCSYPQSLQGQLFTS-RPELFTCDAPLELPSFQLTPSQRQVVFQGDSLP---FQCQASFVAE---------- ---------DMQVLWFQNGR------------MVKADAAQGIFIEKRMVQNCSLIASALTISNIQPGFTGNWECLVRTSR GNTTRTVHIVVLETS----------------------AKYCAPERVSNNRGE---FRWPRTLAGIRAYLPCNRLPSSGGL YSSSS-----------GEEQRAWRYCD--SKGVWAEDDYSRCQFQKDVTRFLYVINQMPLN------------------- ----ESNVVAKARRLLVCTIDAANF---SDKVDIIFVAEMIEKIGKFVEEFKDR-QLGEVMLSMASNLMMADERVLWMAQ REALACSRIIACLQKIAVYRLATAP---------AFSLTSPNIALEAHAVRAG---DWNGMTCMLFQRPIPERSA----- -----------GQDRQLTFKCNMTGSFSSLLHKS---TIVEASLQLPQALLTQPA----VP--GQPEDVVFKLHLLGFRN GKFFPSTG---NSSQLADGGKRRSVATPVIMAKLE-GMPMHVLRTPVNIT----------------LRRLAHG----SDA VSATWNFSLVGGQGGWQSDGCRILGHYDNFTTISCSSLGNYGLLMDLSSMEFFSP------------SILPLHP--VIYA TAVVLLLCLVTVMVTYVYH-----HRAVRVSRKFWHML--------------------LNLCFHICLTFGVFAGGINQ-- ---TRLAGVCQAVGILLHYSTLATALWVGVTAR----------------------------------NIYKQVTRKAKRY EELDE-------PPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIKNYGSRP--NAPYCWMAWEPSIG------ -----------AFYVPVGFIIFIDCMYFLSI------------------------------------------------- ------------------LLQLRRHPERRYELKE-------STEEQHPLSPPHADVGGDGPG-NRHPLTLPLQPPEAS-- ----------SAHHAVPLSALENEHTFPAQLMGAAGALGLYAALWVFAAMAVSQEH-----PFDLVFTCLFG----VAAL ALAAFMVAHHCINRQDVKRLWSRA----------CCSGRRAYS----AQEDVLLPQAGGAAAAATG--DKADGESTK--- --------------------------------------------------------CGHSSADSSCVNKSAASARNSAH- GSKLTNIHAEAAQCKATAG-----------------------------------AAAGNGAAVLDNSLTEHSLDN----- ------------------EIKMHVAPVEVQFRP-------AAAAG-------RHHKNRARAHRASRLTV----------- -----------------LREYAYDVPT---SVDG-SVQ----SAPH---------------------------------- ------------------RRHHYYDMAARNSRR----AAYMAYRERHQSQLQQ--------------------------- ------------------------------------DSSDSAS--LPRRPRHK----------DTERGVASANSSGKDSA KQPSGSELENETKTYGVNLVTQNGAATKE----------NGQLLPLISTENAA---VVKTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Gasterosteus_aculeatus_GPR125_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------FTPPPPPADLLLRLLATLLLACGSAGSSDCKSYDEPPKGGKGGKKSPST---------- --ERKVVCSNMEL-------HQVLPADSFPNRT--VTLILNNNKIQELRNGSF--------------------------- ---IGLFTLEKLDLRSNLISHIEPGAFLGLRA---LKKL-DLSNNSIGCLNVDIFKG-LTNLIRLNLSG----------- ------------------------------------NMFSSLSQGILDSLV------------------------SLKSL -------------------------------------------------------------------------------- --------------------------------------------------------EFQTPYLLCDCNLLWLLRWIKE-R SITVK-NTKCSFPQSLQGQLITSIKPELFTCDAPLELPSFQLTPSQRQVVFQGDSLP---FQCQASFVAE---------- ---------DMQVLWYQNGR------------MVKSDAAQGIFIEKRMVQNCSLIASALTISNIQPGFTGNWECRVRTSR GNTTRTVHIVVLESS----------------------AEYCAPERVSNNKGE---FKWPRTLAGIRAYLPCNRLPSSAGT YSGGA-----------GEEQRAGRLCD--RKGLWTEEDYSRCQYQKDVTRFLYVINQMPLN------------------- ----ESNVVARARRLLVYTIDAANF---SDKMDIIFVAEMIEKFGKFVEKFKD---LGEVMLSMASNLMLADERVLWMAQ REAMACSRIIACLQKIAVYRLATVQ---------VFSLTSPNVALESHVVRAN---DWNGMTCMLFQRSSPER------- -----------TQERQLAFKCNTTSSFSSILHKS---PIVEASLQLPQSLFTQAA----LP--GQAEDTVYKLHLLGLRN GKFFPSTS---NSTQLADGGKRRSVAAPVIMARIE-GMSPRVLRSPVNVT----------------LRRLARG----SDA VSARWNFSLVGGHGGWQSDGCSIVGHNDNFTTISCNSLGNYGLLMDLSSVEYLSP------------SIQPLHP--VIYA TTIILLISLLTIIISYIYH-----HRSVRVSRKFWHML--------------------VNLCFHISLTCGVFVGGINQ-- ---TRHASVCQAVGILLHYSTLATALWVGVTAR----------------------------------NIYKQVTRKAKRY EELDE-------PPPPPRPMLRFYLIG-GGIPIIVCGITAAA-------NIKNYGSRT--NAPYCWMSWEPSIG------ -----------AFYGPVGFIVFVDCMYFLSI------------------------------------------------- ------------------LLQLRRHPERRYELKE-------PSEEQQHLAPANGEAGSEGPGGQCVPLTLQLQPQGASPC SA--------SAAHPVPLSALENEHTFAAQLMGAAGALGLYAALWVFGAMAVSQDH-----PYDLAFTCLFG----VAAL ALGAFMVAHHCVNRQDMRRYWSQA----------CCSGRRAYS----AQEDVLLPQPGVAMTSTAGSASKADGESVK--- --------------------------------------------------------CGHSSADSSYTNKSAPSVRNSAH- GSKLTNLHAEAAQCKPAP-------------------------------------ATANGGAVLDNSLTEHSLDN----- ------------------EIKMHVAPVEVQLRPVSNII-NAAAAATTNGHTSRHHKNRARAHRASRLTV----------- -----------------LREYAYDVPT---SVEG-SVQGSAQSAPH---------------------------------- ------------------RRHHHYDIAARNSRR----AAYMAYRERHQSQQQQQ-------------------------- ------------------------------------DSSDGAS--LPRRSR------------LTEKGGAGTAGDGPPAP DEAAGASLP---KSYGLNLVTQTGGAVKE----------NGHAGPLISPESAA---SVKTGLWKHETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Ciona_intestinalis_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------LAENQISYIGPSTFTNFRN----LKRLNLSHNNIGRLDRSMFLG-LTSLERLYLNN----------- ------------------------------------NIFPLIPGDTFTSLT------------------------SLKRL -------------------------------------------------------------------------------- --------------------------------------------------------NVSSTHLVCNCMMKEFLVWSKMNR TTKLKLNGACTVPLSMKGINLKRVKIKRLKCDVLSDLPYFDIRPAKQQVVFEGDSIS---LHCEGTDLFH---------- ---------AKIN-WSLNGV------------RISNSSMQMFNQTFRRSYDTSVVSSRLTLPNLTAQYSGVWGCTISSNI SFVSKHTEIKVLKTT----------------------AKYCDRVNVTNDMGN---FTWHEAVTGVTVRYNCTEPQQEITM EPHIAS-----------------RQCI--LPGVWSIGNYSQCQFHDPLARYSKVFNALYPL------------------- ---ITEKLVLYFKLLHCTSCNCSTK---MDYSKQISVALLAVSYVLCFVHIIS---LSSSILELMGKSMSSHAFYSILPS HEVVQTCNKLQRILKTTAIGFLSNM--------TNINMKSSNIALAGYNFNVT---DQKYIYCSISEAIEWTELTKYP-- -------ELELVCQDLLLFNFSILLFFHSFLFFILHTYITITVTLG---------------VFVATTFKTIHLLHPGFKN GNLFQSST---TTTNIKPDPERHVLVSSIYSVHVNNRNVVNLTKPAVYIFH--------------TQESVSQLNLDYEHY IAMWNGSGWNRAHHHCIFNHTTRDQQQHNITVIQCDVLATFAIMKQIKVPSRGGNNG---------RQTTLTHP--TVYA GSAVLTLTLLLMLITYAVFRKFIIFSSLLLSRDARHMI--------------------INTTLHLLVAVLTFTVGVWS-- ---ISSKVMCYVTGILLHYSSLSVLLWITLSSG----------------------------------NICKEMLAAQQPP LLEPK----------PSKPMLSLLFYY-GSIPIIICGITASA-------KIENYNGDG---GQYCWLSWETSLY------ -----------AFYAPAACIAIFCILVLLRI------------------------------------------------- ------------------LATLNCAPSGEVENEQ-------SSKTRLQGVALILVL---------------FITTWVT-- -----------AAMTVAAPRIQVCYSNFFNFWYLLLFYLFLISLKFFKQEEPTPSI-----DLHLIFSCIFA----MMCI AMSSFLLIQHLTSRSDVRRSWRNL----------C--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Caenorhabditis_elegans_GPR125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MAKQLKYPFLIFIISLAQCQVSNQNVNLCQSNICQNGGTCLVASSVPATATCP KNSIYYMGSCYVF-------DTTLRNWNDAALYCNNMNSATLPLVESAEDQAFF-------------------------- ---AGYLQAMIPSNPPADMRPPPDGIWTAVRG-VNNVTRASWVYYPGSFLVTDTFWAPQEPNIYVNYNDVCVALQS---- -----------------------------------DSFYREWTTALCTILKYTVCKVAP-------------TQIQAKYV AQCSCPN------------------------------------------------------------------------- --------------------------------------------------------GYGGQTCETQSTTNQQASTQRTCG SNDFQFSCPNDQTITVDFASFGAQESSMCNQASQSREQTCSNVNSLQTVINACQGLQSCEIRNLTSTFSNTPCPVP---- ----QEQYLETRMRCETAQQPSCLSGLIQFDSRCYSMTIETNEKKQRTMEDAQTYCSQSGGSIITSPPDALLQQIVQKVN AETKKTVNFWIGTPNNCQLLMVTG-----------SSTSYSQCPSSPSSTANVICSTVPQSTASVSARPTQSAPVDPVSQ TMARREVYTGVQPPSVPDSINKPRYCKKEKKDGITYEQTRACMLHEQPCPDPQNVEGTVTRYCNCQTAKWETPDTTNCTH RWVAEMETAIKDNQPVEDISSTVNRQLKSTIERTLFGGDITGTVRLSNDMLSLARNQFSVLNDRNLRENKARNFTENLGG SGDQLLSPVAATVWDQLSSTIRIQHA-----SKLMSVLEQSVLLLGDYMTDQKLNLQYINWAMEVERSEPEVQTFGAAAS PNVQDDMGMMRVMAAAPPAPQPETNTTIMFPSLKLSPTITLPSASLLSSLASPTPVAGGGPSILSSFQDDTPVGMASTPN LNRNPVKLGYYAFAGFGQLLNNNNDHTLINSQVIGASIQNATQSVTLPVDHP-------------VTFTFQHLT---TKG VSNPRCVYWDLMESKWSTLGCTLIATSSNSSQCSCTHLTSFAILMDISGQVGRLS------------GGLASALDVVSTI GCAISIVCLALSVCVFTFFR--------NLQNVRNSIH--------------------RNLCLCLLIAELVFVIGMDR-- ---TGNRTGCGVVAILLHYFFLSSFCWMLLEGY----------------------------------QLYMMLIQVFE-- --------------PNRTRIFLYYLFC-YGTPAVVVAISAGI-------KWEDYGTDS-----YCWIDTSTPTIW----- -----------AFVAPIIVIIAANIIFLLIA------------------------------------------------- ------------------LKVVLSVQSRDRTKWG---------------------------------------------- -------------------------RIIGWLKGSATLLCLLGITWIFGFLTAVKGG------TGTAFAWIFT----ILNC TQGIFIFVLHVVLNEKVRASIVRWLRTG----ICCLPETSSAAYNSRSFLSSRQRILN---------MIKVNGHSYP--- --------------------------------------------------------------STASTDDKEKQLTPITKT TDWLSRLPNQDSVSIPES-----------------------------------------NFNNLNGTLENSNLNS----- -------------------AEIKEEDEIPELRRR---------------------------------------------- -----------------------------VTVDLNPMIVSNNEIER---------------------------------- --------------------MSHASSDPRGSQ--------IIEVTAVEKKAP---------------------------- -------------------------------------------------------------------------------- ---------VKRIKFPLGAKQSERGSQHR------------TKAKVIAPPESP---VSESGSKDYRF------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Homo_sapiens_GPR124 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------MGAGGRRMRGAPARLLLPLLP---WLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGP ARRRVVCSGGDLP-------EPP-EPGLLPNGT--VTLLLSNNKITGLRNGSF--------------------------- ---LGLSLLEKLDLRNNIISTVQPGAFLGLGE----LKRLDLSNNRIGCLTSETFQG-LPRLLRLNISG----------- ------------------------------------NIFSSLQPGVFDELP------------------------ALKVV -------------------------------------------------------------------------------- --------------------------------------------------------DLGTEFLTCDCHLRWLLPWAQN-R SLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLP---FQCSASYLGN---------- ---------DTRIRWYHNRA------------PVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQ GNASKKVEIVVLETS----------------------ASYCPAERVANNRGD---FRWPRTLAGITAYQSCLQYPFTSVP LGGGAPGTR------------ASRRCD--RAGRWEPGDYSHCLYTNDITRVLYTFVLMPIN------------------- ----ASNALTLAHQLRVYTAEAASF---SDMMDVVYVAQMIQKFLGYVDQIKE---LVEVMVDMASNLMLVDEHLLWLAQ REDKACSRIVGALERIGGAALSPHA--------QHISVNARNVALEAYLIKPH---SYVGLTCTAFQRREGGVPGTRPGS PGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSL-----PAALAPPVPPDCTLQLLVFRN GRLFHSHS-NTSRPGAAGPGKRRGVATPVIFAGTS-GCGVGNLTEPVAVS----------------LRHWAEG----AEP VAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVG-----------GAGAGLHP--VVYP CTALLLLCLFATIITYILN-----HSSIRVSRKGWHML--------------------LNLCFHIAMTSAVFAGGITL-- ---TNYQMVCQAVGITLHYSSLSTLLWMGVKAR----------------------------------VLHKELTWRAPPP QEGD-------PALPTPSPMLRFYLIA-GGIPLIICGITAAV-------NIHNYRDHS----PYCWLVWRPSLG------ -----------AFYIPVALILLITWIYFLCA------------------------------------------------- ------------------GLRLRGPLAQNPKAGNSRAS--LEAGEELRGSTRLRGS-------------GPLLSDSGSLL ATGSA-----RVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRW-----LPRVVCSCLYG----VAAS ALGLFVFTHHCARRRDVRASWRAC----------CPPASPAAPHAPPRALPAA----------AE-DGSPVFGEGPP--- S-------------------------------------------------------LK-----SSPSGSSGHPL---ALG PCKLTNLQLAQSQVCEAGAAAGGEG--------------------------------EPEPAGTRGNLAHRHPNN----- ---------------------VHHGRRAHKSRAK-------GHRAGE-----ACGKNRLKALRGG--------------- --------------------AAGALELL--SSESGSLHNSPTDSYLG--------------------------------- ---------------------SSRNSPGAGL-----------QLEGEPMLTPS--------------------------- ------------------------------------EGSDTSAAPLSEA--------------GRAGQRRSASRDSLKGG G---ALEKESHRRSYPLNAASLNGAP-----------KGGKYDDVTLMGAEVASGGCMKTGLWKSETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Gorilla_gorilla_GPR124 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MRGAPARLLVPLLPLLPWLLLLLAPEARGAPGCPLPIRSCKCSGERPKGLSGGVPGP ARRRVVCSGGDLP-------EPP-EPGLLPNGT--VTLLLSNNKITGLRNGSF--------------------------- ---LGLSLLEKLDLRNNIISTVQPGAFLGLGE----LKRLDLSNNRIGCLTSETFQG-LPRLLRLNISG----------- ------------------------------------NIFSSLQPGVFDELP------------------------ALKVV -------------------------------------------------------------------------------- --------------------------------------------------------DLGTEFLTCDCHLRWLLPWAQN-R SLQLSERTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLP---FQCSASYLGN---------- ---------DTRIRWYHNRA------------PVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQ GNASKKVEIVVLETS----------------------ASYCPAERVANNRGD---FRWPRTLAGITAYQSCLQYPFTSVP LGGGAPGTR------------ASRRCD--RAGRWEPGDYSHCLYTNDITRVLYTFVLMPIN------------------- ----ASNALTLAHQLRVYTAEAASF---SDMMDVVYVAQMIQKFLGYVDQIKE---LIEVMVDMASNLMLVDEHLLWLAQ REDKACSRIVGALERIGGAALSPHA--------QHISVNARNVALEAYLIKPH---SYVGLTCTAFQRREGGVPGTRPGS PGQNPLPEPEPPADQKLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSL-----PAALAPPVPPDCTLQLLVFRN GRLFRSHS-NTSRPGAAGPGKRRGVATPVIFAGTS-GCGVGNLTEPVEEKN--------------NLGTLLLP----GHP LPRGPRLTGPGKR----------KAGLGAWRGVHIPHVLLPALSQELSAFPREVG-----------GAGAGLHP--VVYP CTALLLLCLFATIITYILN-----HSSIRVSQKGWHML--------------------LNLCFHMAMTSAVFAGGITL-- ---TNYQMVCQAVGITLHYSSLSTLLWMGVKAR----------------------------------VLHKELTWRAPPP QEGD-------PALPTPSPMLRFYLIA-GGIPLIICGITAAV-------NIHNYRDHS----PYCWLVWRPSLG------ -----------AFYIPVALSLLITWIYFLCA------------------------------------------------- ------------------GLRLRGPLAQNPKAG-----------EELRGSTRLRGS-------------GPLLSDSGSLL ATGSA-----RVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRW-----LPRVVCSCLYG----VAAS ALGLFVFTHHCX-------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------------------------------------------------------------------RHPNN----- ---------------------VHHGRRAHKSRAK-------GHRAGE-----ACGKNRLK-------------------- --------------------------LL--SSESGSLHNSPTDSYLG--------------------------------- ---------------------SSRNSPGAGL-----------QLEGEPMLTPS--------------------------- ------------------------------------EGSDTSAAPLSEV--------------GRAGQRRSASRDSLKGG G---ALEKESHRRSYPLNAASLNGAP-----------KGGKYDDVTVMGAEVASGGCMKTGLWKSETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Macaca_mulatta_GPR124 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------MRGAPARLLLPLLL---WLLLLLAPEARGSPGCPLPIRSCKCSGERPKGLSGGVPGP ARRRVVCGGGDLP-------EPP-EPGLLPNGT--VTLLLSNNKITGLRNGSF--------------------------- ---LGLSLLEKLDLRNNIISTVQPGAFLGLGE----LKRLDLSNNRIGCLTSETFRG-LPRLLRLNISG----------- ------------------------------------NIFSSLQPGVFDELP------------------------ALKVV -------------------------------------------------------------------------------- --------------------------------------------------------DLGTEFLTCDCRLRWLLPWAQN-R SLQLSERTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLP---FQCSASYLGN---------- ---------DTRIRWYHNRA------------PVEGDEQAGILLAESLIHDCTFITSGRTSAHCKLRLPGSRHSPASASR VAGTTGARHLARLVF----------------------CLFCLVHRQLP-ASA---PRWPRTLAGITAYQSCLQYPFTSVP LGGGAPGTR------------ASRRCD--RAGRWEPGDYSHCLYTNDITRVLYTFVLMPIN------------------- ----ASNALTLAHQLRVYTAEAASF---SDMMDVVYVAQMIQKFLGYVDQIKE---LVEVMVDMASNLMLVDEHLLWLAQ REDKACSRIILDLVSIKNTKITQEC--------WHAPVNARNVALEAYLIKPH---SYVGLTCTAFQRREGGVPGAQPGS PGQNPRPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSL-----PAALAPPVPPDCTLQLLVFRN GRLFRSHS-NASRPGAAGPGKRRGVATPVIFAGTS-GCGVGNLTEPVAVS----------------LRHWAEG----VEP VAAWWSQEGPGGAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVG-----------GAGAGLHP--VVYP CTALLLLCLFATIITYILN-----HSSIRVSRKGWHML--------------------LNLCFHMAMTSAVFAGGITL-- ---TNYQMVCQAVGITLHYSSLSTLLWMGVKAR----------------------------------VFHKELTWRAPPP QEGD-------PALPAPSPMLRFYLIA-GGIPLIICGITAAV-------NIHNYRDHS----PYCWLVWRPSLG------ -----------AFYIPVALILLITWIYFLCA------------------------------------------------- ------------------GLRLRGLLAQRPKGGNSRAS--LEAGEELRGSTRLRGS-------------GPLLSDSGSLL ATGSA-----RVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRW-----LPRVVCSCLYG----AAAS ALGLFVFTHHCARRRDVRASWRAC----------CPPASPSAPHALPRALPAA----------AAEDGSPVFGEGPP--- S-------------------------------------------------------LK-----SSPSGSSGHPL---ALG PCKLTNLQLAQSQVCEAGAAACGEE--------------------------------EPEAAGPRGSLGPRHPNN----- ---------------------VHHGRRAHKGRAK-------GHRAGE-----AGGKNRLKALRGG--------------- --------------------AAGAPELL--SSESGSLHNSPTDSYLG--------------------------------- ---------------------SSRNSPGVGL-----------QLEGEPMLTPS--------------------------- ------------------------------------EGSDTSAAPLSEA--------------GRPGQRRSASRDSLKGG G---ALEKESKRRSYPLNAASLNGVP-----------KGGKYDDVTMMGAEVASGGCMKTGLWKSETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Mus_musculus_GPR124 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------MGAGGRRMPVPPARLLLLPLLP---CLLL-LAPGTRGAPGCPVPIRGCKCSGERPKGLSGGAHNP ARRRVVCGGGDLP-------EPP-DPGLLPNGT--ITLLLSNNKITGLRNGSF--------------------------- ---LGLSLLEKLDLRSNVISTVQPGAFLGLGE----LKRLDLSNNRIGCLTSETFQG-LPRLLRLNISG----------- ------------------------------------NIYSSLQPGVFDELP------------------------ALKIV -------------------------------------------------------------------------------- --------------------------------------------------------DFGTEFLTCDCRLRWLLPWARN-H SLQLSERTLCAYPSALHAHALSSLQESQLRCEGALELHTHYLIPSLRQVVFQGDRLP---FQCSASYLGN---------- ---------DTRIHWYHNGA------------PMESDEQAGIVLAENLIHDCTFITSELTLSHIGVWASGEWECSVSTVQ GNTSKKVEIVVLETS----------------------ASYCPAERVTNNRGD---FRWPRTLAGITAYQSCLQYPFTSVP LSGGAPGTR------------ASRRCD--RAGRWEPGDYSHCLYTNDITRVLYTFVLMPIN------------------- ----ASNALTLAHQLRVYTAEAASF---SDMMDVVYVAQMIQKFLGYVDQIKE---LVEVMVDMASNLMLVDEHLLWLAQ REDKACSGIVGALERIGGAALSPHA--------QHISVNSRNVALEAYLIKPH---SYVGLTCTAFQRREVGVSGAQPSS VGQDAPVEPEPLADQQLRFRCTTGRPNISLSSFHIKNSVALASIQLPPSLFSTL-----PAALAPPVPPDCTLQLLVFRN GRLFRSHGNNTSRPGAAGPGKRRGVATPVIFAGTS-GCGVGNLTEPVAVS----------------LRHWAEG----ADP MAAWWNQDGPGG---WSSEGCRLRYSQPNVSSLYCQHLGNVAVLMELNAFPREAG-----------GSGAGLHP--VVYP CTALLLLCLFSTIITYILN-----HSSIHVSRKGWHML--------------------LNLCFHMAMTSAVFVGGVTL-- ---TNYQMVCQAVGITLHYSSLSSLLWMGVKAR----------------------------------VLHKELSWRAPPL EEGE-------AAPPGPRPMLRFYLIA-GGIPLIICGITAAV-------NIHNYRDHS----PYCWLVWRPSLG------ -----------AFYIPVALILPITWIYFLCA------------------------------------------------- ------------------GLHLRSHVAQNPKQGN-RIS--LEPGEELRGSTRLRSS-------------GVLLNDSGSLL ATVSA-----GVGTPAPPEDGDGVYSPGVQLGALMTTHFLYLAMWACGALAVSQRW-----LPRVVCSCLYG----VAAS ALGLFVFTHHCARRRDVRASWRAC----------CPPASPSASHVPARALPTA----------TE-DGSPVLGEGPA--- S-------------------------------------------------------LK-----SSPSGSSGRAP---PP- PCKLTNLQVAQSQVCEASVAARGDG--------------------------------EPEPTGSRGSLAPRHHNN----- ---------------------LHHGRRVHKSRAK-------GHRAGE-----TGGKSRLKALRAG--------------- -------------------TSPGAPELL--SSESGSLHNSPSDSYPG--------------------------------- ---------------------SSRNSPGDGL-----------PLEGEPMLTPS--------------------------- ------------------------------------EGSDTSAAPIAET--------------GRPGQRRSASRDNLKGS G--SALERESKRRSYPLNTTSLNGAP-----------KGGKYEDASVTGAEAIAGGSMKTGLWKSETTV----------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------- >Rattus_norvegicus_GPR124 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------MGAGGRRMPVRSARLLLLPLLP---CLLL-LAPGTRGAPGCPVPIRGCKCSGERPKGLSGGAHNP ARRRVVCGGGDLP-------EPP-DPGLLPNGT--ITLLLSNNKITGLRNGSF--------------------------- ---LGLSLLEKLDLRSNVISTVQPGAFLGLGE----LKRLDLSNNRIGCLTSETFQG-LPRLLRLNISG----------- ------------------------------------NIYSSLQPGVFDELP------------------------DLKIV -------------------------------------------------------------------------------- --------------------------------------------------------DFGTEFLTCDCRLRWLLPWARN-H SLQLSERTLCAYPSALHAHALSSLQESQLRCEGALELHTHYLIPSLRQVVFQGDRLP---FQCSASYLGN---------- ---------DTQIHWYHNGA------------PMESDEQAGIVLAENLIHDCTFITSELTLSHIGVWASGEWECSVSTVQ GNTSKKVEIVVLETS----------------------ASYCPAERVTNNRGD---FRWPRTLAGITAYQSCLQYPFTSVP LSGGAPGTR------------ASRRCD--RAGRWEPGDYSHCLYTNDITRVLYTFVLMPIN------------------- ----ASNALTLAHQLRVYTAEAASF---SDMMDVVYVAQMIQKFLGYVDQIKE---LVEVMVDMASNLMLVDEHLLWLAQ REDKACSGIVGALERIGGAALSPHA--------QHISVNSRNVALEAYLIKPH---SYVGLTCTAFQRREVGVSGVQPSS PGQDVPLEPEALADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSTL-----PAALAPPVPPDCTLQLLVFRN GRLFRSHG-NTSRPGTAEPSKRRGVATPVIFAGTS-GCGVGNLTEPVAVS----------------LRHWAEG----TDP LAAWWNQDGPGG---WSSEGCKLRFSQPNVSSLYCQHLGNVAVLMELSAFPREAG-----------GSGAGLHP--VVYP CTALLLLCLFSTIITYILN-----HSSIHVSRKGWHML--------------------LNLCFHMAMTSAVFVGGVTL-- ---TNYQMVCQAVGITLHYSSLSSLLWMGVKAR----------------------------------VLHKELSWRAPPP EEGE-------AAPPGPRPMLRFYLIA-GGIPLIICGITAAV-------NIHNYRDHS----PYCWLVWRPSLG------ -----------AFYIPVALILPITWIYFLCA----