>Homo_sapiens_FGFR1 -----------------------------------------------MEARVSLKRRIELTVEYPWRCGALSPTSNCRTG MWSWKCLLFWAVLVTATL---------------------CTARP------------------------------------ --------------SPTLPEQ------------------AQPWGAPVEVESFLVHPGDLLQLRCRLRDD---VQSINWLR DGVQLAESN------RTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVS----------------------- -------------------------------------------------------------------------------- --------------DALPSSEDDDDDDD-------SSSEEK--------------------------ETDNTKPN--PVA PYWTS-----PEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEF-KPDHRIGGYKVRYAT--WSIIMDSVVPSD KGNYTCIVENEYGSINHTYQLDVVER--SPHRPILQAGLPANKTVALGSNVEFMCK-VYSDPQPHIQWLKHIEVNGSKIG P-DNLPYVQILKTAGVNTTDK---------------------------------EMEVLHLRNVSFEDAGEYTCLAGNSI GLSHHSAWLTVL-------------------------------------------------------------------- ------------------------------------EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGT -KKSD------FHSQMAVHKLAKSIPLRRQVT-----VSADSSASMNSGVLLVRP-SRLSSSGT------PMLAGVS--E YELPEDPR--WELP-RD---RLVLGKPLGEG--CFGQVV-LAEAIGLDKDKPNRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLQARRPPGLEY----------------CYNPSHN PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRIVALTSNQ-----------------------------------------------EYLDLSM P-LDQYSPSFPDTRSS-----------------TCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR----------- ------------------------------ >Pan_troglodytes_FGFR1 -------------------------------------------------------------------------------- MWSWKCLLFWAVLVTATL---------------------CTARP------------------------------------ --------------SPTLPEQ------------------AQPWGAPVEVESFLVHPGDLLQLRCRLRDD---VQSINWLR DGVQLAESN------RTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVS----------------------- -------------------------------------------------------------------------------- --------------DALPSSEDDDDDDDD------SSSEEK--------------------------ETDNTKPNRMPVA PYWTS-----PEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEF-KPDHRIGGYKVRYAT--WSIIMDSVVPSD KGNYTCIVENEYGSINHTYQLDVVER--SPHRPILQAGLPANKTVALGSNVEFMCK-VYSDPQPHIQWLKHIEVNGSKIG P-DNLPYVQILKTAGVNTTDK---------------------------------EMEVLHLRNVSFEDAGEYTCLAGNSI GLSHHSAWLTVL-------------------------------------------------------------------- ------------------------------------EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGT -KKSD------FHSQMAVHKLAKSIPLRRQVT-----VSADSSASMNSGVLLVRP-SRLSSSGT------PMLAGVS--E YELPEDPR--WELP-RD---RLVLGKPLGEG--CFGQVV-LAEAIGLDKDKPNRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLQARRPPGLEY----------------CYNPSHN PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRIVALTSNQ-----------------------------------------------EYLDLSM P-LDQYSPSFPDTRSS-----------------TCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR----------- ------------------------------ >Macaca_mulatta_FGFR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------------------------XPADSGLYACVTSSPLGSDTTYFSVNVS----------------------- -------------------------------------------------------------------------------- --------------DALPSSEDDDDDDD-------SSSEEK--------------------------ETDNTKPNRMPVA PYWTS-----PEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEF-KPDHRIGGYKVRYAT--WSIIMDSVVPSD KGNYTCIVENEYGSINHTYQLDVVER--SPHRPILQAGLPANKTVALGSNVEFMCK-VYSDPQPHIQWLKHIEVNGSKIG P-DNLPYVQILKTAGVNTTDK---------------------------------EMEVLHLRNVSFEDAGEYTCLAGNSI GLSHHSAWLTVL-------------------------------------------------------------------- ------------------------------------EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGT -KKSD------FHSQMAVHKLAKSIPLRRQTR-----VSADSSASMNSGVLLVRP-SRLSSSGT------PMLAGVS--E YELPEDPR--WELP-RD---RLVLGKPLGEG--CFGQVV-LAEAIGLDKDKPNRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLQARRPPGLEY----------------CYNPSHN PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRIVALTSNQ-----------------------------------------------EYLDLSM P-LDQYSPSFPDTRSS-----------------TCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR----------- ------------------------------ >Callithrix_jacchus_FGFR1 -------------------------------------------------------------------------------- MWSWKCLLFWAVLVTATL---------------------CTARP------------------------------------ --------------APTLPEQ------------------AQPWGAPVEVESFLVHPGDLLQLRCRLRDD---VQSIDWLR DGVKLAESN------RTRITGEEVEVWDSVPADSGLYACVTSSPLGSDTTYFSVNVS----------------------- -------------------------------------------------------------------------------- --------------DALPSSEDDDDDDD-------SSSEEK--------------------------ETDNTKPN--PVA PYWTS-----PEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEF-KPDHRIGGYKVRYAT--WSIIMDSVVPSD KGNYTCIVENEYGSINHTYQLDVVER--SPHRPILQAGLPANKTVALGSNVEFMCK-VYSDPQPHIQWLKHIEVNGSKIG P-DNLPYVQILKTAGVNTTDK---------------------------------EMEVLHLRNVSFEDAGEYTCLAGNSI GLSHHSAWLTVL-------------------------------------------------------------------- ------------------------------------EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIIYKMKSST -KKSD------FHSQMAVHKLAKSIPLRRQVT-----VSADSSASMNSGVLLVRP-SRLSSSGT------PMLAGVS--E YELPEDPR--WELP-RD---RLVLGKPLGEG--CFGQVV-LAEAIGLDKDKPSRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLQARRPPGLEY----------------CYNPSHN PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRIVALTSNQ-----------------------------------------------EYLDLSM P-LDQYSPSFPDTRSS-----------------TCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR----------- ------------------------------ >Mus_musculus_FGFR1 -------------------------------------------------------------------------------- MWGWKCLLFWAVLVTATL---------------------CTARP------------------------------------ --------------APTLPEQ------------------AQPWGVPVEVESLLVHPGDLLQLRCRLRDD---VQSINWLR DGVQLVESN------RTRITGEEVEVRDSIPADSGLYACVTSSPSGSDTTYFSVNVS----------------------- -------------------------------------------------------------------------------- --------------DALPSSEDDDDDDD-------SSSEEK--------------------------ETDNTKPN--PVA PYWTS-----PEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEF-KPDHRIGGYKVRYAT--WSIIMDSVVPSD KGNYTCIVENEYGSINHTYQLDVVER--SPHRPILQAGLPANKTVALGSNVEFMCK-VYSDPQPHIQWLKHIEVNGSKIG P-DNLPYVQILKTAGVNTTDK---------------------------------EMEVLHLRNVSFEDAGEYTCLAGNSI GLSHHSAWLTVL-------------------------------------------------------------------- ------------------------------------EALEERPAVMTSPLYLEIIIYCTGAFLISCMLGSVIIYKMKSGT -KKSD------FHSQMAVHKLAKSIPLRRQVT-----VSADSSASMNSGVLLVRP-SRLSSSGT------PMLAGVS--E YELPEDPR--WELP-RD---RLVLGKPLGEG--CFGQVV-LAEAIGLDKDKPNRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLQARRPPGLEY----------------CYNPSHN PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRIVALTSNQ-----------------------------------------------EYLDLSI P-LDQYSPSFPDTRSS-----------------TCSSGEDSVFSHEPLPEEPCLPRHPTQLANSGLKRR----------- ------------------------------ >Oryctolagus_cuniculus_FGFR1 -------------------------------------------------------------------------------- MWSWKCLLFWAVLVTATL---------------------CTARPA----------------------------------- --------------APTLPEQGKA------QAPVPGVAAAQPWGAPVEVESLLVHPGDLLQLRCRLRDD---VQSINWLR DGVQLAESN------RTRITGEEVEVRDSVPADSGLYACVTSSPSGSDTTYFSVNVS----------------------- -------------------------------------------------------------------------------- --------------DALPSSEDDDDDDD-------SSSEEK--------------------------ETDNTKPN--PVA PYWTS-----PEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEF-KPDHRIGGYKVRYAT--WSIIMDSVVPSD KGNYTCIVENEYGSINHTYQLDVVER--SPHRPILQAGLPANKTVALGSNVEFMCK-VYSDPQPHIQWLKHIEVNGSKIG P-DNLPYVQILKTAGVNTTDK---------------------------------EMEVLHLRNVSFEDAGEYTCLAGNSI GLSHHSAWLTVL-------------------------------------------------------------------- ------------------------------------EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIIYKMKSGT -KKSD------FHSQMAVHKLAKSIPLRRQVT-----VSADSSASMNSGVLLVRP-SRLSSSGT------PMLAGVS--E YELPEDPR--WELP-RD---RLVLGKPLGEG--CFGQVV-LAEAIGLDKDKPNRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLQARRPPGLEY----------------CYNPSHN PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRIVALTSNQ-----------------------------------------------EYLDLSM P-LDQYSPSFPDTRSS-----------------TCSSGEDSVFSHEPLPEEPCLPRRSAQLANGGLKRR----------- ------------------------------ >Monodelphis_domestica_FGFR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------D-------SSSEEK--------------------------ESDNTKPN--PVA PYWTS-----PEKMENKLHAVPAAKTVKFKCPSNGTPNPSLRCLKNGKEF-KPDHRIGGYKVRYAT--WSIIMDSVVPSD KGNYTCIVEITFS--CFSFPFFSVER--SPHRPILQAGLPANKTVALGSNVEFMCK-VYSDPQPHIQWLKHIEVNGSKIG P-DNLPYVQILKTAGVNTTDK---------------------------------EMEVLHLRNVSFEDAGEYTCLAGNSI GLSHHSAWLTVL-------------------------------------------------------------------- ------------------------------------EALEERPAVMTSPVYLEIIIYCTGAFLISCMVGSVIIYKMKSGT -KKSD------FHSQMAVHKLAKSIPLRRQVTESRWGVSADSSASMNSGVLLVRP-SRLSSSGT------PMLAGVS--E YELPEDPR--WELP-RD---RLVLGKPLGEG--CFGQVV-LAEAIGLDKDKPNRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLQARRPPGLEY----------------CYNPSHA PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH AIPSQRPTFKQLVEDLDRIVALTSNQ-----------------------------------------------EYLDLSV P-LDQYSPSFPDTRSS-----------------TCSSGEDSVFSHDPLPEEPCLPRHPTQLANGGLKRR----------- ------------------------------ >Ornithorhynchus_anatinus_FGFR1 -------------------------------------------------------------------------------- MWSWKCLLFWAVLVTATL---------------------CPARA------------------------------------ --------------APTLPEH------------------ALPWGAPVEVESSLAHPGDLLQLRCRLRDD---VQSINWLR DGVQLAESN------RTRITGEEVEVRDAVPSDSGLYACVT-TPSGSDITYFSVNVS----------------------- -------------------------------------------------------------------------------- --------------DALPSAEDDDDDDD-------SSSEEK--------------------------ETDNTKPNRTPVA PYWTS-----PEKMEKKLHAVPAAKTVKFKCPSSGTPSPTLRWLKNGKEF-KPDHRIGGYKVRYAT--WSIIMDSVVPSD KGNYTCIVENKYGSINHTYQLDVVER--SPHRPILQAGLPANKTVALGSNVEFVCK-VYSDPQPHIQWLKHIEVNGSKIG P-DNLPYVQILKTAGVNTTDK---------------------------------EMEVLHLRNVSFEDAGEYTCLAGNSI GISHHSAWLTVL-------------------------------------------------------------------- ------------------------------------EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGTVIVYKMKSGT -KKSD------FHSQMAVHKLAKSIPLRRQVT-----VSADSSTSMNSGVLLVRP-SRLSSSGT------PMLAGVS--E YELPEDPR--WELP-RD---RLVLGKPLGEG--CFGQVV-LAEAIGLDKDKPNRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLQARRPPGLEY----------------CYNPSHA PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNDLYMMMRDCWH AVPSQRPTFKQLVEDLDRIVALTSNQ-----------------------------------------------EYLDLSV P-LDQYSPGFPDTRSS-----------------TCSSGEDSVFSHDPLPEEPCLPRHPAQLANGGLKRR----------- ------------------------------ >Gallus_gallus_FGFR1 -------------------------------------------------------------------------------- MFTWRCLILWAVLVTATL---------------------SAARP------------------------------------ --------------APTLPDQ------------------ALPK-ANIEVESHSAHPGDLLQLRCRLRDD---VQSINWVR DGVQLPENN------RTRITGEEVEVRDAVPEDSGLYACMTNSPSGSETTYFSVNVS----------------------- -------------------------------------------------------------------------------- --------------DALPSAEDDDDEDD-------SSSEEK--------------------------EADNTKPNQ-AVA PYWTY-----PEKMEKKLHAVPAAKTVKFKCPSGGTPNPTLRWLKNGKEF-KPDHRIGGYKVRYAT--WSIIMDSVVPSD KGNYTCIVENKYGSINHTYQLDVVER--SPHRPILQAGLPANKTVALGSNVEFVCK-VYSDPQPHIQWLKHIEVNGSKIG P-DNLPYVQILKTAGVNTTDK---------------------------------EMEVLHLRNVSFEDAGEYTCLAGNSI GISHHSAWLTVL-------------------------------------------------------------------- ------------------------------------EATEQSPAMMTSPLYLEIIIYCTGAFLISCMVVTVIIYKMKSTT -KKTD------FNSQLAVHKLAKSIPLRRQVT-----VSADSSSSMNSGVMLVRP-SRLSSSGT------PMLAGVS--E YELPEDPR--WELP-PT---RLILGKPLGEG--CFGQVV-LAEAIGLDKDKPNRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLQARRPPGMEY----------------CYNPTRI PEEQLSFKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRIVAMTSNQ-----------------------------------------------EYLDLSV P-LDQYSPGFPATRSS-----------------TCSSGEDSVFSHDPLPDEPCLPRCPP-HSHGALKRH----------- ------------------------------ >Taeniopygia_guttata_FGFR1 -------------------------------------------------------------------------------- MWTWRCLILWAVLVAAAL---------------------SAARP------------------------------------ --------------APTLPEQ------------------AVPK-AKIEVESHSAHPGELLQLRCRLRDD---VQSINWVH DGVQLAENN------RTRITGEEVEVRDVVPEDSGLYACMTNSPSGSKTTYFSVNVS----------------------- -------------------------------------------------------------------------------- --------------DALPSAEDDDDEDD-------SSSEEK--------------------------EADNTKPNQ-AIA PYWTY-----PEKMEKKLHAVPAVKTVKFKCPSSGTSNPNL-WLKNGKEF-KPDHRIGGYKVQGGA--GEQLLG-VVPSD KGNYTCMWRTSTAASTHTYQLDVVGRKRSPHRPILQAGLPANKTVALGSNVEFVCK-VYSDPQPHIQWLKHIEVNGSKIG P-DNLPYVQILKTAGVNTTDK---------------------------------EMEVLHLRNVSFEDAGEYTCLAGNSI GISHHSAWLTVL-------------------------------------------------------------------- ------------------------------------EAIEDTPAMMTSPIYLEIIIYCIGAFLISCMVVTIIIYKLKSTT -KKTD------FNSQLAVHKLAKSIPLRRQRS-----VSADSSSSMNSGVMLVRP-SRLSSSGT------PMLAGVS--E YELPEDPR--WELP-RD---RLILGKPLGEG--CFGQVV-LAEAIGLDKDKPNRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLQARRPPGMEY----------------CYNPSRV PEEQLSFKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRIVAMTSNQV---------------------------------------------GEYLDLSM P-LDQYSPGFPDTRSS-----------------TCSSGEDSVFSHDPLPDEPCLPKFPPQHSNGGLKRH----------- ------------------------------ >Anolis_carolinensis_FGFR1 -------------------------------------------------------------------------------- MPARRCLHAARVNASAIVHS-------------------CLAFPL----------------------------------- --------------PPSLSLFSP-------------LTLPVLPKTSIEVESLSAHPGDPLQLRCRLRDD---VQSINWVR DGVQLAENN------RTRITGEEVEVRDAVPEDSGLYACMTNSPSGSETTYFSVNVS----------------------- -------------------------------------------------------------------------------- --------------DALPSAEDDDDDDD-------SSSEEK--------------------------EADNSKPNRMVTP VWLCC-----PCRVQSRMRSTGADKTLG----------PTLRWRSK--ED-TVILSMHAFLVRHAT--WSIIMESVVPSD KGNYTCIVENKYGTINHTYQLDVVER--SPHRPILQAGLPANKTVSLGSNVEFVCK-VYSDPQPHIQWLKHIEVNGSRIG P-NNLPYVQVLKTAGVNTTDK---------------------------------EMEVLHLRNVSFEDAGQYTCLAGNSI GISHHSAWLTVL-------------------------------------------------------------------- ------------------------------------EAMEDKPAMMTSPLYLEIIIYCTGGFLISCMIVTVLLYKMKSTT -KKTD------FNSQLAVHKLAKSIPLRRQVT-----VSADSSSSMNSGVMLMRP-SRLSSSGT------PMLAGVS--E YDLPEDPR--WELP-RD---RLILGKPLGEG--CFGQVV-LAEAIGLDKDKPNRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLQARRPPGMEY----------------CYNPTHL PDEQLSFKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDSVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEVLYKNLYRVHWA-CLHRWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRIVAMTSNQ-----------------------------------------------EYLDLSM P-LDQYSPSFPDTRSS-----------------TCSSGEDSVFSHDPLPDEPCLPKHPPQLANGGLKRR----------- ------------------------------ >Xenopus_tropicalis_FGFR1 -------------------------------------------------------------------------------- MFSGRSLLLWGVLLGAAL---------------------SVARP------------------------------------ --------------PSTLPDQ-------------------VAPKTKTDVEPYSARPGDRITLQCRLRED---VQSINWAK NEMQLSETN------RTRITGEEIQISNAGPEDNGVYTCVTNGPSGTYTVLFSVNVS----------------------- -------------------------------------------------------------------------------- --------------DALPSAEDDDDDDDN------SSSEEK--------------------------ASENSKPN----R PFWSH-----PEKMEKKLHAVPAAKTVKFRCPANGTPQPNLRWLKNGKEF-RQDQRIGGYKVRSQT--WSLIMDSVVPSD KGNYTCIVENKYGTLNHTYQLDVVER--SPHRPILQAGLPANTSVIVGSTAEFFCK-VYSDPQPHIQWLRHIEINGSRVA S-DGFPYVEILKTAGVNTSDK---------------------------------DMEVLHLRNVTFEDAGQYTCLAANSI GISHHSAWLTVL-------------------------------------------------------------------- ------------------------------------EVEDDKPAPLASPLQLEIIIYCTGAAFVSAMVITIIIFKMKHPS -KKSD------FNSQLAVHKLAKSIPLRRQVT-----VSGDSNSSMHSGVILVRP-SRLSSSGT------PMLSGVS--E YELPEDPR--WEVA-RD---RLILGKPLGEG--CFGQVV-MAEAIGLDKEKPNKVT-KVAVKMLK---SDASEKDLSDLI SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------CYNPTCA PDQLLSFKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-MEELFKLLKEGHRMDKPTTCTNELYMMMKDCWH AMPSQRPTFNQLVEDLDRILALSSNQ-----------------------------------------------EYLDLSM P-VNQYSPCFPDTRSS-----------------TCSSGEDSVFSHDPLPDEPCLP----KYSNGGLKKR----------- ------------------------------ >Danio_rerio_FGFR1 ----------------------------------------------------------------------------MKMM MIMKTTLLLISVLLTQALQ--------------------SQGRP------------------------------------ ---------------AIQDEA----------------------PAEP--TSYTLDSGEKLELSCKAKED---TQKVTWTK DLVPLVDGE------HTRLRNDQMEIEKVEPTDSGLYACFAQGLNSNHTEYFNIS------------------------- -------------------------------------------------------------------------------- -------------------VTDEEDEVD-------SSSEEA--------------------------KLSNDQN--LPMA PVWAQ-----PDKMEKKLHAVPASKTVKFRCQANGNPTPTLKWLKNGKEF-KRDQRIGGFKVREHM--WTIIMESVVPSD RGNYTCLVENRHGSINHTYQLDVVE--RSPHRPILQAGLPANRTAVVGSDVEFECK-VFSDPQPHIQWLKHIEVNGSRYG P-DGLPYVRALKTAGVNTTDK---------------------------------EMEVLQIRNVSLEDAGEYTCLAGNSI GHSHHSAWLTVY-------------------------------------------------------------------- ------------------------------------KAVPPTQLPNQT--YLEVLIYCVGFFLICVMVGTAVLAKMHSSA -KKSD------FNSQLAVHKLAKSIPLRRQVT-----VSVDSSSSMHSGGMLVRP-SRLSSSGS------PMLSGVS--E YELPQDPR--WEVQ-RD---RLVLGKPLGEG--CFGQVM-MAEAMGMDKEKPNRIT-KVAVKMLK---SDATEKDLSDLI SEMEMMKIIGKHKNIINLLGACTQD---GPLYVIVEFAAKGNLREYLRVRRPPGMEY----------------CYNPDQV PVENMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDRPSTCTHELYMMMRDCWH AVPSQRPTFKQLVEDLDRTLSMTSNQ-----------------------------------------------EYLDLSV S-LDQFSPNFPDTRSS-----------------TCSSGEDSVFSHDAGADEPCLPKFPPHPNRGVAFKKR---------- ------------------------------ >Takifugu_rubripes_FGFR1 -------------------------------------------------------------------------------- -----FICSRTTVLYRALM--------------------QQHVQ------------------------------------ ---------------LCERGV----------------------AVEAPLEMFTLYPGQPLDLSCPASDS---TQAVNWTK DHVLVVDGE------HTRIRNGHLEIESVELSDSGLYACTTFG---NHSGLFNISVD----------------------- -------------------------------------------------------------------------------- --------------V-LASSEDDEEDEE-------SSSEEA--------------------------KLLGSQKE-LPMA PQWAH-----PEKMAKKLHAVPASKTVKFRCQASGNPTPTLKWYKNGREF-KRDHRIGGFKVRDHM--WTIIMEAVVPSD KGNYTCVVENQYGSINHTYQLDVVE--RSPHRPILQAGLPANRTAVVGSDVEFECK-VFSDPQPHIQWLKHIEVNGSRHG P-DGLPYVRILKTAGFNITDK---------------------------------EMEVLQLRNVSFDDAGKYTCLAGNSI GFSHHSAWLTVF-------------------------------------------------------------------- ------------------------------------EAVPHYPPANHT--YLEVVIYCVGFFLIVVMITVAIIVKIRTSS -KKSD------FNSQVAVHKLAKSIPLRRQVT-----VSVDSGSSIHSGAMLVRP-SRLSSSGS------PMLSGVS--E YELPQDPR--WELP-RD---RLVLGKPLGEG--CFGQVV-MGEAMGLDKEKPNRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKIIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------CYNPDQV PVENMSIKDLVSCAFQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSTCTHELYMMMRDCWN AVPSQRPTFKQLVEDLDRCLAMTSNQ-----------------------------------------------EYLELSM P-LDQC---YPDTRSS-----------------TCSSGEDSVFSHDAGAEEPCLPKFPPHSN-GAAIKKR---------- ------------------------------ >Tetraodon_nigroviridis_FGFR1a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------PSA----------------------ATEAPVEMFTLYSGERLDLSCAASDA---TQAVNWTK DQALVVDGE------HTRIHNGHLEIESVELSDSGLYACTTFG---NHSGFFNIS------------------------- -------------------------------------------------------------------------------- ------------------ASEDDEEDEE-------SSSEEA--------------------------KLLGSQKE-LPMA PQWAH-----PEKMAKKLHAVPASKTVKFRCQASGNPIPTLKWYKNGKEF-KREHRIGGFKVRDHM--WTIIMEAVVPSD KGNYTCVVENQYGSINHTYQLDVVE--RSPHRPILQAGLPANRTAVVGSDVEFECK-VFSDPQPHIQWLKHIEVNGSRLG P-DGLPYVRILKTAGFNTTDK---------------------------------EMEVLQLRNVSFEDAGKYTCLAGNSI GFSYHSAWLTVF-------------------------------------------------------------------- ------------------------------------EAVPHYPPANHT--YLEVVIYCVGFFFIAVMITIAIMVKIRTSS -KKSD------FSSQVAVHKLAKSIPLHRQVT-----VSVDSGSSVHSGAMLVRP-SRLSSSGS------PMLSGVS--E YELP-DPR--WELPPGD---RLVLGKPLGEG--CFGQVV-MGEAMGLDRDRPNWVT-KVAVKMLK---ADATEKDLSDLI SEMEMMKIIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------CYNPYQV PVENMSIKDLVSCAFQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSTCTHQLYMMMRDCWH AVPAQRPTFKQLVEDLDRCLAVASNQ-----------------------------------------------EYLELTT P-LDQC---YPDTRSS-----------------TCSSGEDSVFSHDAGAEEPCLPQLPPHAN-GAAVKKR---------- ------------------------------ >Gasterosteus_aculeatus_FGFR1a -------------------------------------------------------------------------------- MLMRPNILLCLVLFSQVLR--------------------TQSRP------------------------------------ ---------------ANNDEA----------------------SVETQVELFTLYLGGSLDLSCSAKDS---PHAVNWTK DHEAVVDGE------HTRIRGVQLVIEAVELTDSGLYACTTFG---NHSNYFNVT------------------------- -------------------------------------------------------------------------------- -------------------AEDDDEEEE-------SSSEEA--------------------------KLLGSQKL-LPMA PEWTH-----PEKMEKKLHAVPASKTVKFRCQASGNPTPSLKWYKNGKEF-KRDHRIGGFKVRDHV--WTIIMESAVPSD KGNYTCLVENEYGSINHTYQLDVVEE-RSPHRPILQAGLPANRTAVVGSDVEFECK-VFSDPQPHIQWLKHEEFNGSRLG P-DGLAYVRVLKSAGLNTTDK---------------------------------EMEVLQLRNVSFDDAGKYTCLAGNSI GYSYHSAWLAVF-------------------------------------------------------------------- ------------------------------------EAVPHYPPASDT--YLEVVIYCVGFFLIVVMIAIAILVKNRTSS -KKSD------FNSPLAVHKLAKSIPLRRQVT-----VSVDSSSSIHSGVMLVRP-SRLSSSGS------PMLSGVS--E YELPQDPR--WELP-RD---RLVLGKPLGEG--CFGLVV-MGEALGLDKEKQNRVT-KVAVKMLK---SDATEKDLSDLI SEMEMMKIIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------CYNPDQV PVETMSIKDLVSCAYQVARGMEYLSSKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTNQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSTCTHELYMMMRDCWH AVPSHRPTFKQLVEDLDRCLAMTSNQ-----------------------------------------------EYLELSV P-LDQYSPNYPDTRSS-----------------TCSSGEDSVFSHDAGAEEPCLPKFPPHSN-GAAIKKR---------- ------------------------------ >Oryzias_latipes_FGFR1a -------------------------------------------------------------------------------- -----HIIYWCFLILKCKL--------------------LLKPD------------------------------------ ---------------GVLPSS----------------------SVDAQPELFTLHLGSRLVLSCSVKDS---LHAVNWTK DQIAVVNGE------HVRINNGQLEIETVELSDSGLYTCTTFG---NHSLYFNVTVV----------------------- -------------------------------------------------------------------------------- --------------YNLASSEDDDDEEE-------SSSEET--------------------------KLLGSQKL-MPMA PQWID-----PEKMEKKLHAVPASKTVKFRCPASGNPIPTLKWYKNGREF-KKDHRIGGFKVREHM--WSIIMESVVPSD KGNYTCVVENQYGSINHTYQLDVVE--RSPHRPILQAGLPANRSVVVGSDVEFHCK-VFSDPQPHIQWLKHIEVNGSGVG P-DGLPHVKILKTAGLNTTDK---------------------------------EMEVLQLRNVSFGDAGQYTCLAGNSI GFSHHTAWLTVL-------------------------------------------------------------------- ------------------------------------EAVTQYPPTSHT--YLEVGIYCAGFFFIAVMVAIAVIIKIRSTS -KKSD------FNSQLAVHKLAKSIPLRRQV-------SVDSSSSNHSGVMLVRP-SRLSSSAS------PMLSGVS--E YELPQDPR--WEVP-RD---KLVLGKPLGEG--CFGQVM-MGEVLGLDKEKPNRVT-NVAVKMLK---SDATEKDLSDLI SEMEMMKIIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------CYNPDQV SVETMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR---LPVKWM APEALFDRIYTHQS----DVWSFGVLL----WEIFTLGGSPYPGVP-VEELFKLLKEGHRMDKPSTCTHELYMMMRDCWH AVPSQRPTFKQLVEDLDRCLAMTSNQ-----------------------------------------------EYLELSV P-LDQYSPSYPDTRSS-----------------TCSSGEDSVFSHDAGAEEPCLPKFPPHSN-GAAIKKR---------- ------------------------------ >Ciona_savignyi_FGFR1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------V PTWTN-----KRKMQKKLHAEPAGNTVTFRCLVNGARPISVDWYKDGEKI-LKNDRLGGYKFRQKS--QCIVLETVILSD RGMYMCVASNAYGSINHTYELDVAVR--MAIPPIVYSDEMKNQTVEIGQTATFRCK-IYSDAHPHIQWIK---FNGN--- -------ITALKKAGVNSTDA---------------------------------DLEKLTLKNVTFEDAGEYVCLAGNSF GSTHASAWLTVIP------------------------------------------------------------------- ------------------------------------VLDKSDVEKNYIQSETHYLIYIFGVICFVILF-VFIIYMCNSHY -QNKD------PPRLVPIENPDNIPRMT----------KMEQPVMLYGNEQAWRR---------------MCLPHADHIE INIQPDLQ--WELK-RE---DILLHERIDEG--FFGQVF-RADLIRCNGGRKEKID--AAVKMLKN---TRTEKDMLDLL TEMDQMKRIGKHKNIVN-LGVCTQNS---ILWLVTEYAQKGNLRDYLRRNRPSEMQYQFTNP---------D-PNAPPPP RDEPLTYHALMSAAHQVARGMEYLSQKKCIHRDLAARNVLVTDEFVMKIADFGLARDVRCNDYYRKQTRGH---LPYKWM AVEAMADNIFTPAT----DVWSFGVLL----WEIFSLGGSPYPGVK-THDLVRFLRSGDRLEQPQFASSELYRLMRDCWE ESPNRRPKFRQLVEDLDRMLASASNVE-----------------------------------------------YIDLNS PCEADYLPSDLDSEDET----------------ESSRDSANATGEDSDSVFEPIEQHGPHVYEVDEANPLLNHEPDSNIM CNGHARMQSDV------------------- >Branchiostoma_floridae_FGFR1 ------------------------------------------------------------------------MGLCRCLQ LRLLLAAMATAAMAAVTSTQD------------------ATPHPGGEGR------------------------------- ---------DVREGTRIFLSRG--------------------GCGRKETSMTKRLKLDGVPKRCSLAYLV-FSWNPTEIS LNTLKALEM------KPVISKGSYNIPVVTYRVGTTHLWTTERDSDDNFSGDGILMDTIGAEG----------------- -------------------------------------------------------------------------------- --------VDDLDVRDLAALRDAGDDEDY------AADEEE--------------------------DEPGMIHDDAPHA PVWQK------PEDNQKIIAAPAGNTVKMRCPATGNPRPTIRWLKDKQEF-RESDRMEGYKIRNKH--WSLVMTGIVPSD EGFYTCIIQNDYGSINHTYELDVIER--SPSRPILAPGLPQNQTVVVGSTVDFQCK-VFSDAQPHIQWLKHYEVNGSYVD A-NGKPHVRVLKSSSMDFSDTDTIPIDDTSGI------------------GKTDAAEKLIIRNVEQSDAGKYTCRAESYL GSVNQSAWLFVFKEYPTPP------------------------------------------------------------- -----------------------------------TVETRKPVQPDKYDIAAEIAVYSVGGVFLLTIFAFVAIYYFRFKR -KQVP------KSNEPPLCQLKKPLHLKRQVS-------LESSSSINSNAPLVRLRSTR--LSS-------SLGGVT--E YELPLDPD--WEFP-RD---R----------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------ >Hydra_magnipapillata_FGFR1 --------------------------------------------------------------------MISDWCVVLVLS ISKLVFGLN----------------------------------------------------------------------- ------------------------------------------FTEPVNYILKIGENNSSRLLDCSVGLSVELIKKIDWTY NGIVINKKPN----VTFTDKGQKLIIGHYKPHNSGRYGCKITAVSEESVERIFDLLP----------------------- -------------------------------------------------------------------------------- --------------TSVICFYFIIDLMPR--------------------------------------------------- -----------IKNDISLLVELVMNKLDLDCTAVGASPISITWLKNDKLI-EARS---NLRYSFSPNFLKLSIKEVRLDD AGIYKCILENKYGKIEHVMTVEIYEK---VFSKPIIYSTDKHKVFYADYGQNLTVPVYVTAFLPYPHFEMLYVYNKTIPN TNETKINVRKRPTFRELTVLEISQRKGTSIN----------------------HIRLDYFFTNISEQDFGNYTLMAGNKY GYDRYPFQILHTKYMQTTVSPP---------------------------------------------------------- -----------------------------------MKANINKIYKEESVEKTVIFIVIASMLAGLIFVAFFFFFICRVRS KEKFK-------NSNINYIKPSQTVILNLGDN-------NTSGVTMVTSVSAFSYANRRFRHSLN----NNPVNDKQKYN LKIAPDPA--WEIKLEQ----LETDCLLGEG--AFGRVF---RATARDLPNRTGVQ-TVAVKMLK---EDCCEQDLKDFI SEIEVMKSIGKHINILNLLAVSSQQG---KLYIVVEYCRHGNLRSFLKDNRPV--TQANS---------------VITKK ----ITSYDLMSFCLQVARGMNYLASKKCIHRDIAARNVLVGEGYLLKVADFGLARDVREHDYYRKCT-DGR--LPVKWM AIEALFDRVYTTQS----DIWSFGILA----WEIVTFGGSPYPGIA-LENMFDLLKQGYRMEKPPNCTDDMYALMLNCWK EIPSKRPTFSQLIEDLERMLLNASST-----------------------------------------------EYIDLQP IQPERAELFSTSIHTSTS-------------MLNTDLFNKNKYDHDEVSFTHEDGLSEADVLLNYQVVS----------- ------------------------------ >Homo_sapiens_FGFR2 -------------------------------------------------------------------------------- MVSWGR--FICLVVVTMATL-------------------SLARPSFS--------------------------------- ----------LVEDTTLEPEE------------------PPTKYQISQPEVYVAAPGESLEVRCLLKD----AAVISWTK DGVHLGPNN------RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----------------------- -------------------------------------------------------------------------------- --------------DAISSGDDEDDTDG---------AEDF--------------------------VSENSNNK---RA PYWTN-----TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEF-KQEHRIGGYKVRNQH--WSLIMESVVPSD KGNYTCVVENEYGSINHTYHLDVVER--SPHRPILQAGLPANASTVVGGDVEFVCK-VYSDAQPHIQWIKHVEKNGSKYG P-DGLPYLKVLKHSGINSSN-----------------------------------AEVLALFNVTEADAGEYICKVSNYI GQANQSAWLTVLPK------------------------------------------------------------------ -----------------------------------QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTT -KKPD------FSSQPAVHKLTKRIPLRRQVT-----VSAESSSSMNSNTPLVRITTRLSSTADT-----PMLAGVS--E YELPEDPK--WEFP-RD---KLTLGKPLGEG--CFGQVV-MAEAVGIDKDKPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SYDINRV PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRILTLTTN-----------------------------------------------EEYLDLSQ P-LEQYSPSYPDTRS------------------SCSSGDDSVFSPDPMPYEPCLPQYP--HINGSVKT------------ ------------------------------ >Pan_troglodytes_FGFR2 -------------------------------------------------------------------------------- MVSWGR--FICLVVVTMATL-------------------SLARPSFS--------------------------------- ----------LVEDTTLEPEE------------------PPTKYQISQPEVYVAAPGESLEVRCLLKD----AAVISWTK DGVHLGPNN------RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----------------------- -------------------------------------------------------------------------------- --------------DAISSGDDEDDTDG---------AEDF--------------------------VSENSNNK---RA PYWTN-----TEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEF-KQEHRIGGYKVRNQH--WSLIMESVVPSD KGNYTCVVENEYGSINHTYHLDVVER--SPHRPILQAGLPANASTVVGGDVEFVCK-VYSDAQPHIQWIKHVEKNGSKYG P-DGLPYLKVLKHSGINSSN-----------------------------------AEVLALFNVTEADAGEYICKVSNYI GQANQSAWLTVLPK------------------------------------------------------------------ -----------------------------------QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTT -KKPD------FSSQPAVHKLTKRIPLRRQVT-----VSAESSSSMNSNTPLVRITTRLSSTADT-----PMLAGVS--E YELPEDPK--WEFP-RD---KLTLGKPLGEG--CFGQVV-MAEAVGIDKDKPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SYDINRV PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRILTLTTN-----------------------------------------------EEYLDLSQ P-LEQYSPSYPDTRS------------------SCSSGDDSVFSPDPMPYEPCLPQYP--HINGSVKT------------ ------------------------------ >Gorilla_gorilla_FGFR2 ------------------------------------------------------------MGLTSTWRYGRGPGIGTVT- MVSWGR--FICLVVVTMATL-------------------SLARPSFS--------------------------------- ----------LVEDTTLEPEE------------------PPTKYQISQPEVYVAAPGESLEVRCLLKD----AAVISWTK DGVHLGPNN------RTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT----------------------- -------------------------------------------------------------------------------- --------------DAISSGDDEDDTDG---------AEDF--------------------------VSENSNNK---RA PYWTN-----TEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEF-KQEHRIGGYKVRNQH--WSLIMESVVPSD KGNYTCVVENEYGSINHTYHLDVVER--SPHRPILQAGLPANASTVVGGDVEFVCK-VYSDAQPHIQWIKHVEKNGSKYG P-DGLPYLKVLKHSGINSSN-----------------------------------AEVLALFNVTEADAGEYICKVSNYI GQANQSAWLTVLPK------------------------------------------------------------------ -----------------------------------QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTT -KKPD------FSSQPAVHKLTKRIPLRRQVT-----VSAESSSSMNSNTPLVRITTRLSSTADT-----PMLAGVS--E YELPEDPK--WEFP-RD---KLTLGKPLGEG--CFGQVV-MAEAVGIDKDKPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SYDINRV PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRILTLTTN-----------------------------------------------EEYLDLSQ P-LEQYSPSYPDTRS------------------SCSSGDDSVFSPDPMPYEPCLPQYP--HINGSVKT------------ ------------------------------ >Macaca_mulatta_FGFR2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------------------------------------GA PYWTN-----TEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEF-KQEHRIGGYKVRNQH--WSLIMESVVPSD KGNYTCVVENEYGSINHTYHLDVVER--SPHRPILQAGLPANASTVVGGDVEFVCK-VYSDAQPHIQWIKHVEKNGSKYG P-DGLPYLKVLKHSGINSSN-----------------------------------AEVLALFNVTEADAGEYICKVSNYI GQANQSAWLTVLPK------------------------------------------------------------------ -----------------------------------QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTT -KKPD------FSSQPAVHKLTKRIPLRRQV-------SAESSSSMNSNTPLVRITTRLSSTADT-----PMLAGVS--E YELPEDPK--WEFP-RD---KLTLGKPLGEG--CFGQVV-MAEAVGIDKDKPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQD---GENGWASRSCSQSTPHEHKEGSVPAGLEFLT--------------SSDPSTL TSQSVGITGMSHCTQPHS--VSYSILQLCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRILTLTTN-----------------------------------------------EEYLDLSQ P-LEQYSPSYPDTRS------------------SCSSGDDSVFSPDPMPYEPCLPQYP--HINGSVKT------------ ------------------------------ >Mus_musculus_FGFR2 -------------------------------------------------------------------------------- MVSWGR--FICLVLVTMATL-------------------SLARPSFS--------------------------------- ----------LVEDTTLEPEE------------------PPTKYQISQPEAYVVAPGESLELQCMLKD----AAVISWTK DGVHLGPNN------RTVLIGEYLQIKGATPRDSGLYACTAARTVDSETWYFMVNVT----------------------- -------------------------------------------------------------------------------- --------------DAISSGDDEDDTDS---------SEDV--------------------------VSENRSNQ---RA PYWTN-----TEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEF-KQEHRIGGYKVRNQH--WSLIMESVVPSD KGNYTCLVENEYGSINHTYHLDVVER--SPHRPILQAGLPANASTVVGGDVEFVCK-VYSDAQPHIQWIKHVEKNGSKYG P-DGLPYLKVLKHSGINSSN-----------------------------------AEVLALFNVTEMDAGEYICKVSNYI GQANQSAWLTVLPK------------------------------------------------------------------ -----------------------------------QQAPVREKEITASPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTT -KKPD------FSSQPAVHKLTKRIPLRRQVT-----VSAESSSSMNSNTPLVRITTRLSSTADT-----PMLAGVS--E YELPEDPK--WEFP-RD---KLTLGKPLGEG--CFGQVV-MAEAVGIDKDKPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SYDINRV PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPTNCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRILTLTTN-----------------------------------------------EEYLDLTQ P-LEQYSPSYPDTRS------------------SCSSGDDSVFSPDPMPYEPCLPQYP--HINGSVKT------------ ------------------------------ >Oryctolagus_cuniculus_FGFR2 ------------------------------------------------------------MGFTSTWRYGRGPGIGTVT- MVGWGR--FICLVMVTMATV-------------------SLARPSFN--------------------------------- ----------LVEDATVEPEE------------------PPTKYQISQPEVYVAAPGESLELRCLLKD----ASVISWTK DGVHLGPNN------RTVLIGEYLQIRGATPRDSGLYACTAARTVDSDTWYFMVNVT----------------------- -------------------------------------------------------------------------------- --------------DAISSGDDEDDTDG---------AEDF--------------------------VSENSNSK---RA PYWTN-----TEKMEKRLHAVPAANTVKFRCPAGGSPTPTMRWLKNGKEF-KQEHRIGGYKVRNQH--WSLIMESVVPSD KGNYTCVVENEYGSINHTYHLDVVER--SPHRPILQAGLPANASTVVGGDVEFVCK-VYSDAQPHIQWIKHVEKNGSKYG P-DGLPYLKVLKHSGINSSN-----------------------------------AEVLALFNVTEADAGEYICKVSNYI GQANQSAWLTVLPK------------------------------------------------------------------ -----------------------------------QQAPVREKEITASPDYLEIAIYCIGVFLIVCMVITVIVCRMKTTS -KKPD------FSSQPAVHKLTKRIPLRRQVT-----VSAESSSSMNSNTPLVRITTRLSSAADT-----PMLAGVS--E YELPEDPK--WEFP-RD---KLTLGKPLGEG--CFGQVV-MAEAVGIDKDKPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVLVEYASKGNLREYLRARRPPGMEY----------------SYDINRV PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRILTLTTN-----------------------------------------------EEYLDLSQ P-LEQYSPSYPDSRS------------------SCSSGDDSVFSPDPMPYEPRLPQYP--HVNGSVQT------------ ------------------------------ >Equus_caballus_FGFR2 -------------------------------------------------------------------------------- MVSWGR--FICLVVVTMATL-------------------SLARPSFN--------------------------------- ----------LVEDTTLEPEE------------------PPTKYQISQPEVYVAAPGESLELRCLLRD----AAMISWTK DGVHLGPSN------RTVLIGEYLQIKGATPRDSGLYACTAARTVDSETVYFMVNVT----------------------- -------------------------------------------------------------------------------- --------------DAISSGDDEDDTDG---------SEDF--------------------------VSESSNNK---RA PYWTN-----TEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEF-KQEHRIGGYKVRNQH--WSLIMESVVPSD KGNYTCVVENEYGSINHTYHLDVVER--SPHRPILQAGLPANASTVVGGDVEFVCK-VYSDAQPHIQWIKHVEKNGSKYG P-DGLPYLKVLKHSGINSSN-----------------------------------AEVLALFNVTEADAGEYICKVSNYI GQANQSAWLTVLPK------------------------------------------------------------------ -----------------------------------QQAPVREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKTTT -KKPD------FSSQPAVHKLTKRIPLRRQVF-----VSAESSSSMNSNTPLVRITTRLSSTADT-----PMLAGVS--E YELPEDPK--WEFP-RD---KLTLGKPLGEG--CFGQVV-MAEAVGIDKEKPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SYDINRV PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRILTLTTN-----------------------------------------------EEYLDLSQ P-LEQYSPSYPDTRS------------------SCSSGDDSVF----LCYDPCLPQYP--HINGSVKT------------ ------------------------------ >Dasypus_novemcinctus_FGFR2 ------------------------------------------------------------MGLTSTWRHGRGSGLGTVT- MVSWGR--FVCLVAVTMATV-------------------SLARPSFN--------------------------------- ----------LVEDTTFEPEE------------------PPTKYQISQPDVYVAAPGESLELRCLLKD----AAMISWTK DGVHLGPNN------RTVLIGEYLQIKGATSRDSGLYTCTAARTVDSETLYFIVNVT----------------------- -------------------------------------------------------------------------------- --------------DAISSGDDEDDTDG---------PEDF--------------------------VSEN-NNK---RA PYWTN-----TEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEF-KQEHRIGGYKVRNQH--WSLIMESVVPSD KGNYTCVVENEYGSINHTYHLDVVER--SPHRPILQAGLPANASAVVGGDVEFVCK-VYSDAQPHIQWIKHVEKNGSKYG P-DGLPYLKVLKHSGINSSN-----------------------------------AEVLALFNVTEADAGEYICKVSNYI GQANQSAWLTVLPK------------------------------------------------------------------ -----------------------------------QQAPVREKEITSSPDYLEIAIYCIGVFLIACMVVTVILCRMKTTT -KKPD------FGSQPAVHKLTKRIPLRRQVT-----VSAESSSSMNSNTPLVRITTRLSSTADT-----PMLAGVS--E YELPEDPK--WEFP-RD---KLTLGKPLGEG--CFGQVV-MAEAVGIDKDKPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SYDINRV PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRILTLTTN-----------------------------------------------EEYLDLSQ P-LEQYSPSYPDTRS------------------SCSSGDDSVFSPDPMPYEPCLPQYP--HANGSVKT------------ ------------------------------ >Pteropus_vampyrus_FGFR2 ------------------------------------------------------------MGLTSTWRYGRGRGIGTVT- MVSWGR--FVCLVVVTMATS-------------------SLARPS-N--------------------------------- ----------LVKDTTLEPEE------------------PPTKYQISQPEVYVAAPGDSLELRCQLRD----AAVISWTK DGGQLGPSN------RTVLIGEYLQIEGATPRDSGLYACTAARTVDSETVYFMVNVT----------------------- -------------------------------------------------------------------------------- --------------DAISSGDDEDDTDG---------SEDF--------------------------VSENRDNK---RA PYWTN-----TEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEF-KQEHRIGGYKVRNQH--WSLIMESVVPSD KGNYTCVVENEYGSINHTYHLDVVER--SPHRPILQAGLPANASTVVGGDVEFVCK-VYSDAQPHIQWIKHVEKNGSKYG P-DGLPYLKVLKHSGINSSN-----------------------------------AEVLALFNVTEADAGEYICKVSNYI GQANQSAWLTVLPK------------------------------------------------------------------ -----------------------------------QQAPVREKEITTSPDYLEIAIYCIGVFLIACMVVTVIVCRMKTTT -KKPD------FSSQPAVHKLTKRIPLRRQVT-----VSAESSSSMNSNTPLVRITTRLSSTADT-----PMLAGVS--E YELPEDPK--WEFP-RD---KLTLGKPLGEG--CFGQVV-MAEAVGIDKEKPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SYDINRV PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRVLTLTAN-----------------------------------------------EEYLDLSQ P-LEQYSPSFPDTRS------------------SCSSGDDSVFSPDPMPYEPCLPQYP--HINGSVKT------------ ------------------------------ >Gallus_gallus_FGFR2 ------------------------------------------------------------MGLKSTWRYGNGPGTYSKK- MVSWDSGCLICLVVVTMAGL-------------------SLARPSFNL-------------------------------- ----------VVEDATLEPEE------------------PPTKYQISQPDVHSALPGEPLELRCQLKD----AVMISWTK DGVPLGPDN------RTVIIGEYLQIKDASPRDSGLYACTAIRTLDSDTLYFIVNVT----------------------- -------------------------------------------------------------------------------- --------------DALSSGDDEDDNDG---------SEDF--------------------------VNDS-NQM---RA PYWTH-----TDKMEKRLHAVPAANTVKFRCPAMGNPTPTMRWLKNGKEF-KQEHRIGGYKVRNQH--WSLIMESVVPSD KGNYTCIVENQYGSINHTYHLDVVER--SPHRPILQAGLPANASAVVGGDVEFVCK-VYSDAQPHIQWIKHVERNGSKYG P-DGLPYLQVLKAAGVNTTDK---------------------------------EIEVLYIRNVTFEDAGEYTCLAGNSI GISFHTAWLTVLP------------------------------------------------------------------- -------------------------------------APEKEKEFPTSPDYLEIAIYCIGVFLIACMVLTVILCRMKNTT -KKPD------FSSQPAVHKLTKRIPLRRQVT-----VSADSSSSMNSNTPLVRITTRLSSTADA-----PMLAGVS--E YELPEDPK--WEFP-RD---KLTLGKPLGEG--CFGQVV-MAEAVGIDKDRPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SFDINRV PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWQ AVPSQRPTFKQLVEDLDRILTLTTN-----------------------------------------------EEYLDLSG P-LEQYSPSYPDTRS------------------SCSSGDDSVFSPDPMPYEPCLPKYQ--HMNGSVKT------------ ------------------------------ >Taeniopygia_guttata_FGFR2 ------------------------------------------------------------MGLKSTWRYGNGPGIYSKK- MVRWDSGCLICLVVVTMAGL-------------------SLARPSFNL-------------------------------- ----------VVEDTTVEPEE------------------PPTKYQISQPDVYSALPGETLELRCQLRD----AVMISWTK DGLPLGPDN------RTVIIGEYLQIKDATARDSGLYACTAVRTLDSDTLYFIVNVT----------------------- -------------------------------------------------------------------------------- --------------DALSSGDDEDDNDG---------SEDF--------------------------VNDS-NQM---RA PYWTH-----TDKMEKRLHAVPAANTVKFRCPAMGNPTPTMRWLKNGKEF-KQEHRIGGYKVRNQH--WSLIMESVVPSD KGNYTCIVENQYGSINHTYHLDVVER--SPHRPILQAGLPANASAVVGGDVEFVCK-VYSDAQPHIQWIKHVEKNGSKYG P-DGLPYLQVLKAAGVNTTDK---------------------------------EIEVLYIRNVTFEDAGEYTCLAGNSI GISFHTAWLTVLP------------------------------------------------------------------- -------------------------------------APEKEKEYPTSPDYVEIAIYCIGVFLIACMVLTVILCRMKNTT -KKPD------FSSQPAVHKLTKRIPLRRQV-------SADSSSSMNSNTPLVRITTRLSSAADA-----PMLAGVS--E YELPEDPK--WEFP-RD---KLTLGKPLGEG--CFGQVV-MAEAVGIDKDRPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SFDINRV PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWH AVPSHRPTFKQLVEDLDRILTLTTN-----------------------------------------------EEYLDLSG P-LEQYSPSYPDTRS------------------SCSSGDDSVFSPDPMPYEPCLPKYQ--HMNGSVKT------------ ------------------------------ >Anolis_carolinensis_FGFR2 ------------------------------------------------------------MGLKSTWRYGRGPGTGTEK- MVSWDSCCLICLVVITMAGF-------------------SLARPSYNL-------------------------------- ----------VGEDTTLEPEE------------------PPTKYQISQPEAHTVLPGETLKLHCQLKD----ATMITWTK DGVHLVPNN------RTIISGEYLWIKDTTPRDSGLYACT----VDSETLYFITNIT----------------------- -------------------------------------------------------------------------------- --------------DVLSSGDDEDDNDG---------SEDF--------------------------VNDN-NPI---KG PKWTQ-----TDKMEKRLHAVPAANTVKFRCPATGNPMPTMRWLKNGKEF-KQEHRIGGYKVRNQH--WSLIMESVVPSD KGNYTCIVENIHGSINHTYHLDVVER--SPHRPILQAGLPANTSAILGGEAKFVCK-VYSDAQPHIQWIKHIEKNGSKYG P-DGLPYLEVLKHSGINSSN-----------------------------------TEVLKLHNVTEEDAGEYICKVSNYI GEANQSAWLVVLP------------------------------------------------------------------- -----------------------------------DKAPVEDRPYPTSPDYLEIAIYCVGVFLIVCMVMTVILCRMRSTT -KKSD------FSSQPAVHKLTKRIPLRRQVT-----VSADSSSSMNSNTPLVRITTRLSSNTDA-----PMLAGVS--E YELPEDPK--WEFP-RD---KLTLGKPLGEG--CFGQVV-MAEAVGIDKDRPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVLVEYASKGNLREYLRARRPPGMEY----------------SFDINRV PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMRDCWH AVPSQRPTFKQLVEDLDRILTLTTN-----------------------------------------------EEYLDLSG P-LEQYSPSYPDTRS------------------SCSSGDDSVFSPDPMPYEPCLPKYQ--HINGSVKT------------ ------------------------------ >Danio_rerio_FGFR2 -------------------------------------------------------------------------------- -MFARGWLLGALLLMTLATV-------------------SVARPSLKID------------------------------- ----------LVN--TSAPEE------------------PPTKNQNCVPVLFSVHPGELLKLKCPLSG----ADDVVWTK DSSSLRPDN------RTLVTRDWLQISDATPKDSGLYSCSATGSRDCDVFSFIVNVT----------------------- -------------------------------------------------------------------------------- --------------DAISSGDDEDDTER---------SDDV--------------------------GADGEQM----RL PYWTF-----PEKMEKKLHAVPAANTVKFRCAAAGNPKPKMRWLKNAKPF-RQEDRMGGYKVRLQH--WTLIMESVVPSD KGNYTCLVENQYGSINHTYTLDVVER--SPHRPILQAGLPANVTVQVGQDAKFVCK-VYSDAQPHIQWLQHYTKNGSRYG P-DGLPYVRVLKSSGINSSD-----------------------------------VEVLMLTNVTEEDAGEITCKVSNYI GEANNSCWLIVIPA------------------------------------------------------------------ -----------------------------------E---TNPIETDYPPDYVEIAIYCIGVFLIACMVVIVVVCRMRTSA -KKPD------FSSQPAVHKLTKQIPLRRQVT-----VSSDSSSSMSSSTPLVRITTRR-SSAHD-----DPIP-----E YDLPEDPR--WEFS-RD---KLTLGKPLGEG--CFGQVV-MAEALGIDKDKPKEAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGRHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SYDIARV SDEPLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTNELYMMMKDCWH AISSHRPTFKQLVEDLDRILTLATN-----------------------------------------------EEYLDLCA P-VEQYSPSFPDTRS------------------SCSSGDDSVFSHDPLADEPCLPKYQ--HINGGIKT------------ ------------------------------ >Takifugu_rubripes_FGFR2 -------------------------------------------------------------------------------- -MSSWAWLLAAVLVS-LLTA-------------------SVARPPLTAA------------------------------- ----------KEEEATQRPED------------------TSNKYQISKPTVCSVHPGEVLKLSCPLPA----TGTISWTK DGSSLGANN------RTLIEQEVLQIRDATPKDSGLYTCTSVGK---DTVCFIVNVT----------------------- -------------------------------------------------------------------------------- --------------DAISSGDDEDDTER---------SEDS--------------------------GADGEQPTL--GA PYWIS-----SAKMEKKLHAVPAANTVKFRCAAGGNPEPKLRWLKNNRPF-RQEDRMGGYKVRNQH--WTLIMESVVPSD KGNYTCLVENEFGSINHTYTLDVVER--SPHRPILQAGLPANTTVHVGEDARFVCK-VYSDAQPHIQWLKHIAQNGSRFG P-DGNPYVRVLKRSGINSSD-----------------------------------VEILTLTNVTEEDAGEYICKVSNYI GEASQSGWLTVIPE------------------------------------------------------------------ -----------------------------------RETSIEESHGPLSPHYVEIAIYCAGVFLIACMVGIVVVCRMRNTT -KKPD------FGGQPAVHKLSKQIPLRRQVT-----VSADSSSSMNSNTPLVRITTRR-SSAHD-----EPIP-----E YDLPEDPR--WEFT-RD---RLTLGKPLGEG--CFGQVV-MAEALGVDKDKPKEAV-TVAVKMLK---DDATEKELSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SYDIARV SDEQLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNIMKIADFGLARDVHNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPGNCTNELYMMMKDCWH AISSQRPTFKQLVEDLDRILTLSSNE----------------------------------------------EYLDLCIP --SEQYSPSFPDTRS------------------SCSSGDDSVFSHDPLPDEPCLPKYQ--HINGNVKT------------ ------------------------------ >Tetraodon_nigroviridis_FGFR2a -------------------------------------------------------------------------------- -MALWAWLLAAVLLS-LLTA-------------------SVARPPLTAA------------------------------- ----------KEAEVTQEPED------------------TSNKNQISKPTVCSVHPGEVLKLSCPLPA----TGTITWTK DGSSLGANN------RTLIEQEVLQIRDATPRDSGLYTCTSVGK---DTVCFIVNVT----------------------- -------------------------------------------------------------------------------- --------------DATSSGDDEDDTER---------SEDS--------------------------GAEAEQP----SA PYWIS-----PEKMEKKLHAVPAANTVKFRCAAGGNPEPKLRWLKNNRPF-RQEDRMGGYKVRSQH--WTLIMESVVPSD KGNYTCLVENEYGSINHTYFLDVVER--SPHRPILQAGLPANTTVHVGEDARFVCK-VYSDAQPHIQWLKHISQNGSSVG P-DGNAYVRVLKTAGVNTTDK---------------------------------EIEVLYLHNVTFEDAGEYTCLAGNSI GLSHQTAWLTVLPA------------------------------------------------------------------ -----------------------------------R----EESQDPLSPHYVEIAIYCAGVFLIACMVGIVVVCRMRNTT -KKPD------FGGQPAVHKLSKQIPLRRQVT-----VSADSSASMNSNTPLVRIMTRR-SIAHD-----EPIP-----E YDLPEDPR--WEFA-RD---RLTLGKPLGEG--CFGQVV-MAEALGIDKDKPKEAV-TVAVKMLK---DDATEKELSDLV SEMEMMKMIGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SYDIARV SDEQLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNIMKIADFGLARDVHNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPGNCTNELYMMMKDCWH AISSQRPTFKQLVEDLDRILALSSNE------------------------------------------------------ -------VSLPQP------------------------------------------------------------------- ------------------------------ >Gasterosteus_aculeatus_FGFR2b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------PTLCSVHPGELLKLSCPLSP----PGTITWTK DGSSVGTNN------RTVIEQEVLQIRDATAKDSGLYTCTSVGK---KTVCFIVNVT----------------------- -------------------------------------------------------------------------------- --------------DAISSGDDEDDSER---------SEDT--------------------------GVDEEQI----SA PFWTS-----TAKMEKRLHAVPAANTVKFRCAAGGNPRPKMRWLKNSRPF-RQEDRMGGYKVRSQH--WTLIMESVVPSD KGNYTCLVENEFGAINHTYTLDVVER--SPHRPILQAGLPANITVHVGEDARFVCK-VYSDAQPHIQWLKHISRNGSRYG P-DGHPYVQVLKTAGVNTTDK---------------------------------EIEALYLPNVTFEDSGEYTCLAGNSI GISYHTAWLTVLP------------------------------------------------------------------- --------------------------------------AIEKSIGPFSPDYVEIAIYCAGVFLIACMVGIVVVCRMRNTA -KKPD------FGGQPAVHKLSKQIPLRRQV-------SADSSSSMNSSTPLVRITTRR-SSAHD-----DRIP-----E YDLPEDPC--WEFS-RD---RLTLGKPLGEG--CFGQVV-MAEALGIDKDKTKDAV-TVAVKMLK---DDATEKDLSDLV SEMEMMKMIGKHKNIINLLGACTQE---GPLYVIVEYASKGNLREY--------MEY----------------SYDIARV SDEQLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNFMKIADFGLARDVHNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPGNCTNELYMMMKDCWH AISSHRPTFKQLVEDLDRILSLNTNE----------------------------------------------EESVDLC- -------------------------------------------------------------------------------- ------------------------------ >Oryzias_latipes_FGFR2 ------------------------------------------------------------------------LFLTLWLL SSSFFFFTLCTLFLL-YFTL-------------------LSPHPPLSFT------------------------------- ----------PSPPPVCS-AE------------------ASNKYQISKPTVCSVHPGEALRLSCPLPA----TGTITWTK DGSSLGTNN------HTVIEQDVLQIRDATPKDSGLYACTSVGK---DTVFFIVNVT----------------------- -------------------------------------------------------------------------------- --------------DAISSGDDEDDTER---------SEDT--------------------------GLDGVQS----RP PYWTS-----PAKMEKRLHAVPAANTVKFRCAAGGNPRPSLRWLKNQKPF-RQEDRMGGYKVRSQH--WTLLMESVVPSD KGNYTCVVENELGSINHTYTLDVVER--SPHRPILQAGLPANTTVHVGEDARFVCK-VYSDAQPHIQWLKHITQNGSRLG P-DGHPYVRVLKTAGVNTTDK---------------------------------EIEVLHLPNVTFEDAGEYTCLAGNSI GISYHTATLTVLPG------------------------------------------------------------------ -----------------------------------H-SAPEKSPGPISPDYVEIAIYCAGVFLILCMVVIVVVCRMRTTA -KKPD------FNGQPAVHKLTKQLPLRRQVT-----VSSDSSSSMNSNTPLVRITTRR-SSAHD-----LPIP-----E YDLPEDPR--WEFS-RD---RLTLGKPLGEG--CFGQVV-MAEALGIDKDKPKEAA-TVAVKMLK---DDATEKDLSDLV SEMEMMKMMGKHKNIINLLGACTQD---GPLYVIVEYASKGNLREYLRARRPPGMEY----------------SYDIARV SDEQLTFKDLVSCTYQVARGMEYLASKKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKTTNGR---LPVKWM APEALFDRVYTH----QSDVWSFGVLM----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPGNCTNELYMMMKDCWH AISSQRPTFKQLVEDLDRILSLSTN-----------------------------------------------EEYLDLCA P-TEQYSPSFPDTRS------------------SCSSGDDSVFSHDPLPDEPCLPKYQ--HINGNVKR------------ ------------------------------ >Homo_sapiens_FGFR3 -------------------------------------------------------------------------------- MGAPACALALCVAVAIVA--------------------GASSESLGTEQ------------------------------- -------RVVGRAAEVPGPEPG-------------------------QQEQLVFGSGDAVELSCPPPGGG-PMGPTVWVK DGTGLVPSE------RVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVT------------------------ -------------------------------------------------------------------------------- --------------DAPSSGDDEDGEDE-------AEDTG-----------------------------------VDTGA PYWTR-----PERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREF-RGEHRIGGIKLRHQQ--WSLVMESVVPSD RGNYTCVVENKFGSIRQTYTLDVLER--SPHRPILQAGLPANQTAVLGSDVEFHCK-VYSDAQPHIQWLKHVEVNGSKVG P-DGTPYVTVLKSWISESVEA---------------------------------DVR-LRLANVSERDGGEYLCRATNFI GVAEKAFWLSVHGPRA---------------------------------------------------------------- ------------------------------------AEEELVEADEAGSVYAGILSYGVGFFLFILVV-AAVTLCRLRSP -PKKG------LGS-PTVHKISRFPLKR-QVS-------LESNASMSSNTPLVRIAR----LSS---GEGPTLANVS--E LELPADPK--WELS-RA---RLTLGKPLGEG--CFGQVV-MAEAIGIDKDRAAKPV-TVAVKMLK---DDATDKDLSDLV SEMEMMKMIGKHKNIINLLGACTQGG---PLYVLVEYAAKGNLREFLRARRPPGLDYS----------------FDTCKP PEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGR---LPVKWM APEALFDRVYTHQS----DVWSFGVLL----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTHDLYMIMRECWH AAPSQRPTFKQLVEDLDRVLTVTSTDE-----------------------------------------------YLDLSA P-FEQYSPGGQDTPSSS----------------SS--GDDSVFAHDLLPPAP------PSSGGSRT-------------- ------------------------------ >Macaca_mulatta_FGFR3 -------------------------------------------------------------------------------- MGAPACALALCVAVAIVA--------------------GASSESLGTEQ------------------------------- -------RVVGRVAEVSGPEPS-------------------------QQEQLVFGSGDAVELSCPPPGGG-PMGPTVWVK DGAGLVPSE------RVLVGPQRLQVLNASHEDSGAYSCRQRLTQLVLCHFSVRVT------------------------ -------------------------------------------------------------------------------- --------------DAPSSGDDEDGEDE-------AEDTG-----------------------------------VDTGA PYWTR-----PERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEF-RGEHRIGGIKLRHQQ--WSLVMESVVPSD RGNYTCVVENKFGSIRQTYTLDVLER--SPHRPILQAGLPANQTAVLGSDVEFHCK-VYSDAQPHIQWLKHVEVNGSKVG P-DGTPYVTVLKSWISESVEA---------------------------------DVR-LRLANVSERDGGEYLCRATNFI GVAEKAFWLSVHRPRA---------------------------------------------------------------- ------------------------------------AEEELVEADEAGSVYAGILSYGVGFFLFILVV-AAVTLCRLRST -PKKG------LGS-PTVHKISRFPLKR-QVS-------LESNASMSSNTPLVRIAR----LSS---GEGPTLANVS--E LELPADPK--WELS-RA---RLTLGKPLGEG--CFGQVV-MAEAIGIDKDRAAKPV-TVAVKMLK---DDATDKDLSDLV SEMEMMKMIGKHKNIINLLGACTQGG---PLYVLVEYAAKGNLREFLRARRPPGLDYS----------------FDTCKP PEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGR---LPVKWM APEALFDRVYTHQS----DVWSFGVLL----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTHDLYMIMRECWH AAPSQRPTFKQLVEDLDRVLTVTSTDE-----------------------------------------------YLDLSA P-FEQYSPGGQDTPSSS----------------SS--GDDSVFAHDLLPPAP------PSSGGSRT-------------- ------------------------------ >Mus_musculus_FGFR3 -------------------------------------------------------------------------------- MVVPACVLVFCVAV--VA--------------------GATSEPPGPEQ------------------------------- -------RVVRRAAEVPGPEPS-------------------------QQEQVAFGSGDTVELSCHPPGGA-PTGPTVWAK DGTGLVASH------RILVGPQRLQVLNASHEDAGVYSCQHRLTRRVLCHFSVRVT------------------------ -------------------------------------------------------------------------------- --------------DAPSSGDDEDGEDV-------AEDT---------------------------------------GA PYWTR-----PERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEF-RGEHRIGGIKLRHQQ--WSLVMESVVPSD RGNYTCVVENKFGSIRQTYTLDVLER--SPHRPILQAGLPANQTAILGSDVEFHCK-VYSDAQPHIQWLKHVEVNGSKVG P-DGTPYVTVLKSWISENVEA---------------------------------DAR-LRLANVSERDGGEYLCRATNFI GVAEKAFWLRVHGPQA---------------------------------------------------------------- ------------------------------------AEEELMETDEAGSVYAGVLSYGVVFFLFILVV-AAVILCRLRSP -PKKG------LGS-PTVHKVSRFPLKR-QVS-------LESNSSMNSNTPLVRIAR----LSS---GEGPVLANVS--E LELPADPK--WELS-RT---RLTLGKPLGEG--CFGQVV-MAEAIGIDKDRTAKPV-TVAVKMLK---DDATDKDLSDLV SEMEMMKMIGKHKNIINLLGACTQGG---PLYVLVEYAAKGNLREFLRARRPPGMDYS----------------FDACRL PEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGR---LPVKWM APEALFDRVYTHQS----DVWSFGVLL----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPASCTHDLYMIMRECWH AVPSQRPTFKQLVEDLDRILTVTSTDE-----------------------------------------------YLDLSV P-FEQYSPGGQDTPSSS----------------SS--GDDSVFTHDLLPPGP------PSNGGPRT-------------- ------------------------------ >Rattus_norvegicus_FGFR3 -------------------------------------------------------------------------------- MVVPACVLVFCVAV--VA--------------------GVTSEPPGPEQ------------------------------- -------RVGRRAAEVPGPEPS-------------------------QQEQVAFGSGDTVELSCHPPGGA-PTGPTLWAK DGVGLVASH------RILVGPQRLQVLNATHEDAGVYSCQQRLTRRVLCHFSVRVT------------------------ -------------------------------------------------------------------------------- --------------DAPSSGDDEDGEDV-------AEDT---------------------------------------GA PYWTR-----PERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEF-RGEHRIGGIKLRHQQ--WSLVMESVVPSD RGNYTCVVENKFGSIRQTYTLDVLER--SPHRPILQAGLPANQTAVLGSDVEFHCK-VYSDAQPHIQWLKHVEVNGSKVG P-DGTPYVTVLKTAGANTTDR---------------------------------ELEVLSLHNVTFEDAGEYTCLAGNSI GFSHHSAWLVVLP------------------------------------------------------------------- ------------------------------------AEEELMEVDEAGSVYAGVLSYGVGFFLFILVV-AAVTLCRLRSP -PKKG------LGS-PTVHKVSRFPLKR-QVS-------LESNSSMNSNTPLVRIAR----LSS---GEGPVLANVS--E LELPADPK--WELS-RT---RLTLGKPLGEG--CFGQVV-MAEAIGIDKDRTAKPV-TVAVKMLK---DDATDKDLSDLV SEMEMMKMIGKHKNIINLLGACTQGG---PLYVLVEYAAKGNLREFLRARRPPGMDYS----------------FDACRL PEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGR---LPVKWM APEALFDRVYTHQS----DVWSFGVLL----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTHDLYMIMRECWH AVPSQRPTFKQLVEDLDRILTVTSTDE-----------------------------------------------YLDLSV P-FEQYSPGGQDTPSSS----------------SS--GDDSVFTHDLLPPGP------PSNGGPRT-------------- ------------------------------ >Canis_familiaris_FGFR3 -------------------------------------------------------------------------------- -MVPPGGRVQVLSIPALG--------------------APALR------------------------------------- --------SSISPTETPGPEPG-------------------------QQEPLVFGSGDTVELTCPSPIDS-PTGPSIWVK DGVGLVPSD------RILVGPRRLQVLNASHEDAGTYSCRQRLTQRILCHFSVRVT------------------------ -------------------------------------------------------------------------------- --------------DAPSSGDDEDGEDE-------AEDTGSGG--------------------------------QRAGA PYWTR-----PERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEF-RGEHRIGGIKLRHQQ--WSLVMESVVPSD RGNYTCVVENKFGSIRQTYTLDVLER--SPHRPILQAGLPANQTAVLGSDVEFHCK-VYSDAQPHIQWLKHVEVNGSKVG P-DGTPYVTVLKTAGANTTDK---------------------------------ELEVLSLRNVTFEDAGEYTCLAGNSI GFSHHSAWLVVLP------------------------------------------------------------------- ------------------------------------AEEELVEAGEAGSVYAGVLSYGVGFLLFILVV-AAVTLCRLRTP -PKKG------LGS-PTVHKVSRFPLKR-QVS-------LESNSSMNSNTPLVRIAR----LSS---GEGPALANVS--E LELPADPK--WELS-RA---RLTLGKPLGEG--CFGQVV-MAEAIGIDKDRAAKPV-TVAVKMLK---DDATDKDLSDLV SEMEMMKMIGRHKNIINLLGACTQGG---PLYVLVEYAAKGNLREYLRARRPPGMDYS----------------FDTCKL PEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGR---LPVKWM APEALFDRVYTHQS----DVWSFGVLL----WEIFTLGGSPYPGIP-VEELFKLLKEGHRMDKPANCTHDLYMIMRECWH AVPSQRPTFKQLVEDLDRILTVTSTDE-----------------------------------------------YLDLSV P-FEQYSPGGQDTPSSS----------------SS--GDDSVFAHDLLPPAP------PGGGGPRT-------------- ------------------------------ >Bos_taurus_FGFR3 -------------------------------------------------------------------------------- MGAPARALAFCVAVAVMT--------------------GAALGSPGVEP------------------------------- -------RVARRAAEVPGPEPS-------------------------PQE-RAFGSGDTVELSCRLPAGV-PTEPTVWVK DGVGLAPSD------RVLVGPQRLQVLNASHEDAGAYSCRQRLSQRLLCLFSVRVT------------------------ -------------------------------------------------------------------------------- --------------DAPSSGDDEGGDDE-------AEDTAG--------------------------------------A PYWTR-----PERMDKKLLAVPAANTVRFRCPAAGNPTPSITWLKNGKEF-RGEHRIGGIKLRQQQ--WSLVMESVVPSD RGNYTCVVENKFGRIQQTYTLDVLER--SPHRPILQAGLPANQTAVLGSDVEFHCK-VYSDAQPHIQWLKHVEVNGSKVG P-DGTPYVTVLKTAGANTTDK---------------------------------ELEVLSLRNVTFEDAGEYTCLAGNSI