>Homo_sapiens_FGF18 -------------------------------------------------------------------------------- ----------------------------------------------MYSAPSACTCLCLHFLLLCFQ-VQV--------- -------------------------------------------------------------------LVAEEN-VDFR-- --------------------------------------IHVENQTRARDDVSRKQLRLYQL-------YSRTS------- ---------GKHIQVL------------GRRIS--ARGEDGDKYA------------------QLLVETDTFGSQVRIK- -------GKETEFYLCMNRKGKLVGK---------------PDGTSKE----------CVFIEKVLENN----------- YTALMSAKYS------------------------------GWYVGFTKKGRPR----KGPK------------------T RENQQDVHFMKRYP-KGQP------------------------------------------------------------- -------------------------------------------------------------------------------- -----ELQKPFKYTT---VTKRSRRIR---PTHPA--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Canis_familiaris_FGF18 -------------------------------------------------------------------------------- ----------------------------------------------MYSAPSACTCLCLHFLLLCFQ-VQV--------- -------------------------------------------------------------------LAAEEN-VDFR-- --------------------------------------IHVENQTRARDDVSRKQLRLYQL-------YSRTS------- ---------GKHIQVL------------GRRIS--ARGEDGDKYA------------------QLLVETDTFGSQVRIK- -------GKETEFYLCMNRKGKLVGK---------------PDGTSKE----------CVFIEKVLENN----------- YTALMSAKYS------------------------------GWYVGFTKKGRPR----KGPK------------------T RENQQDVHFMKRYP-KGQA------------------------------------------------------------- -------------------------------------------------------------------------------- -----ELQKPFKYTT---VTKRSRRIR---PTHPG--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Bos_taurus_FGF18 -------------------------------------------------------------------------------- ----------------------------------------------MYSAPSACTCLCLHFLLLCFQ-VQV--------- -------------------------------------------------------------------LAAEEN-VDFR-- --------------------------------------IHVENQTRARDDVSRKQLRLYQL-------YSRTS------- ---------GKHIQVL------------GRRIS--ARGEDGDKYA------------------QLLVETDTFGSQVRIK- -------GKETEFYLCMNRKGKLVGK---------------PDGTSKE----------CVFIEKVLENN----------- YTALMSAKYS------------------------------GWYVGFTKKGRPR----KGPK------------------T RENQQDVHFMKRYP-KGQA------------------------------------------------------------- -------------------------------------------------------------------------------- -----ELQKPFKYTT---VTKRSRRIR---PTHPG--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Gallus_gallus_FGF18 -------------------------------------------------------------------------------- -------------------------------------------VPYPPSRCSGLFCSWFLLCCFL---TVM--------- -------------------------------------------------------------------FVAEEN-VDFR-- --------------------------------------IHVENQTRARDDVSRKQLRLYQL-------YSRTS------- ---------GKHIQVL------------GRRIS--AKGEDGDKYEA-----------------QLLVETDTFGSQVRIK- -------GKETDFYLCMNRKGKLVGK---------------PDGTSKE----------CVFIEKVLENN----------- YTALMSAKYS------------------------------GWYVGFTKKGRPR----KGPK------------------T RENQQDVHFMKRYP-KGQV------------------------------------------------------------- -------------------------------------------------------------------------------- -----EIQKPFKYTT---VTKRTKRIR---PTNPS--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Anolis_carolinensis_FGF18 -------------------------------------------------------------------------------- -----------------------------------------------------MLNLFLLPSLFLKK-TQM--------- -------------------------------------------------------------------FVAEEN-VDFR-- --------------------------------------IHVENQTRARDDVSRKQLRLYQL-------YSRTS------- ---------GKHIQVM------------GRRIS--AKGEDGDKY-A-----------------QLLVETDTFGSQVRIK- -------GKETDFYLCMNRKGKLVGK---------------PDGTSKE----------CVFIEKVLENN----------- YTALMSAKYS------------------------------GWYVGFTKKGRPR----KGPK------------------T RENQQDVHFMKRYP-KGIV------------------------------------------------------------- -------------------------------------------------------------------------------- -----DLQKPFKYTT---VTKRTRRIR---PTNPS--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Danio_rerio_FGF18_a -------------------------------------------------------------------------------- -----------------------------------------------WKKMASISCRYIQMMLVMCNPLQ---------- -------------------------------------------------------------------VFGVDG-VNFS-- --------------------------------------VHVENQTRARDAMSRRQHRVYQL-------YSRTS------- ---------GKHVQVL------------GRKIS--ARGDDGDKY-A-----------------QLVVEADTFGSQVRIR- -------GKETNFYLCMNRKGKLVGK---------------KASNRGAD---------CVFIEKVLENN----------- YTALMSARYT------------------------------GWYVGFTKRGRPR----RGPH------------------T LPNQQDVHFMKRFPPGEQP------------------------------------------------------------- -------------------------------------------------------------------------------- -----DL-MPFRFTT---VSKRSKKVR---AARPR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Danio_rerio_FGF18_b -------------------------------------------------------------------------------- ----------------------------------------------MRSVLWSAVVLCYQVVLLFYSPLQ---------- -------------------------------------------------------------------VLAVDN-VNFG-- --------------------------------------VHVENQTGVRDGLSRKHHRVYQI-------YSRTS------- ---------GKHVQVL------------GKKIT--AMGEDGDKY-A-----------------QLVVEADTFGSQVRIR- -------GKETNYYLCMNRKGKLIGK---------------KDSSVNGG---------CVFIEIMLENN----------- YTAWMSAHYV------------------------------GWYVGFTKKGRPR----RGPN------------------T LPNQRDVHFMKRFPPGEQP------------------------------------------------------------- -------------------------------------------------------------------------------- -----DL-QPCSFTT---VSKRSKRVQQPSASPPPLP------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Takifugu_rubripes_FGF18_a -------------------------------------------------------------------------------- ----------------------------------------------MWSLLSTLTVLCIQMLLVMCNPLQQ--------- -------------------------------------------------------------------VLGVDG-VNFS-- --------------------------------------VHVENQTQVRDTMSRRHHRVYQL-------YSRTS------- ---------GKHVQVL------------GRKIS--ARGEDGDKYEA-----------------QLVVEADTFGSQVRIR- -------GKETNFYLCMNNRGKLVGM---------------TANNRSED---------CVFVEKVLENN----------- YTALMSARYA------------------------------DYYVGFTKKGRPR----RGRK------------------M LPNERDVHFMKRFPPGEQP------------------------------------------------------------- -------------------------------------------------------------------------------- -----NLTTPFRFTT---VSKRGKRVR---ATGPR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Tetraodon_nigroviridis_FGF18_a -------------------------------------------------------------------------------- ----------------------------------------------SSGSHFFCFYRCIQMLLVMCNPLQ---------- -------------------------------------------------------------------VLGVDG-VNFS-- --------------------------------------VHVENQTQVRDTMSRRHHRVYQL-------YSRTS------- ---------GKHVQVL------------GRRIS--ARGEDGDKYEA-----------------QLVVEADTFGSQVRIR- -------GKETNFYLCMNRRGKLVGK---------------KASNRSAD---------CVFVEKVLENN----------- YTALMSARYT------------------------------DWYVGFTKRGRPR----RGPN------------------T LPNQQDVHFMKRFPPGEQP------------------------------------------------------------- -------------------------------------------------------------------------------- -----NLTTPFRFTT---VSKRGKRVR---ATGPR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Gasterosteus_aculeatus_FGF18_a -------------------------------------------------------------------------------- --------------------------------------------VLLSLLITFCICLRMPTSRCVCVLSQQ--------- -------------------------------------------------------------------VLSVDG-VNFS-- --------------------------------------VHVENQTQVRDTMSRRQHRVYQL-------YSRTS------- ---------GKHVQVL------------GRRIS--ARGEDGDKFEA-----------------QLVVEADTFGSQVRIR- -------GKATDFYLCMNRRGKLVGK---------------KASNRSDD---------CVFVEKVLENH----------- YTALMSARHA------------------------------GWYVGFTKRGRPR----RGPQ------------------T LPNQQDVHFMKRFPPGEQP------------------------------------------------------------- -------------------------------------------------------------------------------- -----DFTTPFRFTT---VSKRGKRVR---ATGPR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Oryzias_latipes_FGF18_a -------------------------------------------------------------------------------- ----------------------------------------------MWSLLSTLTVLCIQMLLVMCNPLQ---------- -------------------------------------------------------------------VLGVDG-VNFS-- --------------------------------------VHVENQTQVRDTMSRRHHRVYQL-------YSRTS------- ---------GKHVQVL------------GRRIS--ARGEDGDKYEA-----------------QLVVEADTFGSQVRIR- -------GKETNFYLCMNSRGKLVGK---------------KASNRSAD---------CVFVEKVLENH----------- YTALMSARYT------------------------------DWYVGFNKRGRPR----PGSR------------------T QPNQQDGHFMKRFPPGEQP------------------------------------------------------------- -------------------------------------------------------------------------------- -----DLTTPFRFTT---ISKRGNRVR---ANGPR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Ciona_intestinalis_FGF18 -------------------------------------------------------------------------------- ---------------------------------------------MRPSI-CKDIYANLYRFLLGIIVLGDIAS------ -------------------------------------------------------------------GIPPNYIRD---- --------------------------------------YIKSEIFQENVSQSSSTRRYCEI-------YSKRT------- ---------SNHIRIL------------GKKVD--GRGRRGSNH------------------AKLIIHSKGLWGRIMIQ- -------GVQTERFLCMNKRGRLVGKN-------------YRKAINDPK---------CLFFEEMLENY----------- FDAFSNSKFR------------------------------DWHIGFHSNGRPK----RGPH------------------T KEIGTDEMFIKKCTASSGMVPNPTAASNEKYKWIIGEFERDVKRHNKKKKRAPLS------------------------- ----------VLRPNYSVTRDSSTADEVMLADSSRTLSTLPPYVQAEIERRRSLYPVLRQQRRLDVTIPPAGGTVSAMDP LYSSPKHRKLPRRNKPRRSRQNKKRKHRRHKSKWRSTVPTDIVDSDFQPTTGT---FTTPFPINSVSEPEAGFIRTP--- TTAPGLHRQRSRSGRRRPKQRRRTKKVHGRKQKTGRRNRKRANT------------------------------------ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Homo_sapiens_FGF17 -------------------------------------------------------------------------------- ---------------------------------------------MGAARLLPNLTLCLQLLILCC-QTQ---------- --------------------------------------------------------------------GENHPSPNFN-- --------------------------------------QYVRDQGAMTDQLSRRQIREYQL-------YSRTS------- ---------GKHVQVT------------GRRIS--ATAEDGNKF------------------AKLIVETDTFGSRVRIK- -------GAESEKYICMNKRGKLIGK---------------PSGKSKD----------CVFTEIVLENN----------- YTAFQNARHE------------------------------GWFMAFTRQGRPR----QASR------------------S RQNQREAHFIKRLYQGQLPFPN---------------------------------------------------------- -------------------------------------------------------------------------------- ---HAEKQKQFEFVG-SAPTRRTKRTRRPQPLT----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Mus_musculus_FGF17 -------------------------------------------------------------------------------- ---------------------------------------------MGAARLLPNLTLCLQLLILCC-QTQ---------- --------------------------------------------------------------------GENHPSPNFN-- --------------------------------------QYVRDQGAMTDQLSRRQIREYQL-------YSRTS------- ---------GKHVQVT------------GRRIS--ATAEDGNKF------------------AKLIVETDTFGSRVRIK- -------GAESEKYICMNKRGKLIGK---------------PSGKSKD----------CVFTEIVLENN----------- YTAFQNARHE------------------------------GWFMAFTRQGRPR----QASR------------------S RQNQREAHFIKRLYQGQLPFPN---------------------------------------------------------- -------------------------------------------------------------------------------- ---HAERQKQFEFVG-SAPTRRTKRTRRPQSQT----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Canis_familiaris_FGF17 -------------------------------------------------------------------------------- ---------------------------------------------MGATCLLPNLTLCLQLLILCC-QTQVTAK------ --------------------------------------------------------------------GENHPSPNFN-- --------------------------------------QYVRDQGAMTDQLSRRQIREYQL-------YSRTS------- ---------GKHVQVT------------GRRIS--ATAEDGNKF------------------AKLIVETDTFGSRVRIK- -------GAESEKYICMNKRGKLIGK---------------PSGKSKD----------CVFTEIVLENN----------- YTAFQNARHE------------------------------GWFMAFTRQGRPR----QASR------------------S RQNQREAHFIKRLYQGQLPFPN---------------------------------------------------------- -------------------------------------------------------------------------------- ---HAERQKQFEFVG-SAPTRRTKRTRRPQPLT----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Bos_taurus_FGF17 -------------------------------------------------------------------------------- ---------------------------------------------MGAARLLPNLTLCLQLLILCC-QTQG--------- ----------------------------------------------------------------------NEVKPRER-- --------------------------------------EHERDRCAPCRRVSRQEVVCFSP-------IQRCR------- ---------WTQIQKS------------GPLLHPWAGSPNGRRFLPLPT-------------AKLIVETDTFGSRVRIK- -------GAESEKYICMNKRGKLIGK---------------PSGKSKD----------CVFTEIVLENN----------- YTAFQNARHE------------------------------GWFMAFTRQGRPR----QASR------------------S RQNQREAHFIKRLYQGQLPFPN---------------------------------------------------------- -------------------------------------------------------------------------------- ---HAERQKQFEFVG-SAPTRRTKRTRRPQPLT----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Loxodonta_africana_FGF17 -------------------------------------------------------------------------------- ---------------------------------------------MEAARLLPNLTLCLQLLILCC-QTQVTAK------ --------------------------------------------------------------------GENHPSPNFN-- --------------------------------------QYVRDQGAMTDQLSRRQIREYQL-------YSRTS------- ---------GKHVQVT------------GRRIS--ATAEDGNKF------------------AKLIVETDTFGSRVRIK- -------GAESEKYICMNKRGKLIGK---------------PSGKSKD----------CVFTEIVLENN----------- YTAFQNARHE------------------------------GWFMAFTRQGRPR----QASR------------------S RQNQREAHFIKRLYQGQLPFPN---------------------------------------------------------- -------------------------------------------------------------------------------- ---HAERQKQFEFVG-SAPTRRTKRTRRPQPIT----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Danio_rerio_FGF17_a -------------------------------------------------------------------------------- ----------------------------------------------MYGINQRYLYISFHFFVVWC-HAQG--------- --------------------------------------------------------------------EKNHPSPNFK-- --------------------------------------QYVREQGSLTDQLSRRQVRVYQL-------YSRTS------- ---------GKHVQIR------------GHRVS--ATADDGNSY------------------ARLYVETDTFGSRVRIK- -------GAESGRYLCMNRRGKLVGK---------------PNGRGRD----------CIFTEIVLENN----------- YTALENARHE------------------------------GWFVAFTRKGRPI----RASK------------------T RQNQREVHFIKRLHKGPQPFP----------------------------------------------------------- -------------------------------------------------------------------------------- ---NAEQPKHFEFIS-FPSTRRAKRNRKHQTAS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Takifugu_rubripes_FGF17_a -------------------------------------------------------------------------------- ---------------------------------------------VALSNPIPLFCRSIHFFVLWC-HAQKK-------- --------------------------------------------------------------------GENHPSPNFK-- --------------------------------------QYVRTQGEVSDQLSRRQVRVYQL-------YSRTS------- ---------GKHVQIQ------------GKRVT--ATAEDGNIY------------------ARLLVETDSFGSRVRIR- -------GAESGHYLCMNRRGKLVGK---------------PNGRSRE----------CIFSEIVLENN----------- YTALQNAKYE------------------------------GWYVAFSRKGRPI----KASR------------------T RQNQREVHFIKRLHAGPPPFP----------------------------------------------------------- -------------------------------------------------------------------------------- ---NMDQSKHFEFFR-FSATSRAKRNRKSGTVS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Tetraodon_nigroviridis_FGF17_a -------------------------------------------------------------------------------- ----------------------------------------------MQGITQRCVYISLHFLALWC-QAQ---------- --------------------------------------------------------------------GENHPSPNFK-- --------------------------------------QHVRTQGAASDPLSRRQVRVYQL-------YSRTS------- ---------GQHVQIQ------------GRRVT--ATAADGSPH------------------ARLFVETDSFGSRVRIR- -------GAESGRYLCMNRKGKLVAK---------------PNGESRE----------CIFSEIVLENN----------- YTAFQNAKYE------------------------------GWYVAFSRKGRPI----KASR------------------T RENQREVHFIKRLHAGPPPFP----------------------------------------------------------- -------------------------------------------------------------------------------- ---NVDQSQHFEFIR-LSGTRRAKRNRKTRTFS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Gasterosteus_aculeatus_FGF17_a -------------------------------------------------------------------------------- ----------------------------------------------MYGINQRCIYISFHLFVLWC-HAQKK-------- --------------------------------------------------------------------GENHPSPHFK-- --------------------------------------QYVRTQGAGTDQLSRRQVRVYQL-------YSRTS------- ---------GKHVQIH------------GRRVT--ATAEDGDVF------------------ARLFVETDTFGSRVRIR- -------GAESRRYLCINRKGKLVGK---------------PNGRSRD----------CIFTEIVLENN----------- YTAFQNAKYE------------------------------GWYVAFTRKGRPV----KASR------------------T RENQREVHFIKRLHTGPPSFP----------------------------------------------------------- -------------------------------------------------------------------------------- ---NTDQSKQFEFIR-FPAASRAKRNRKSRTFS----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Drosophila_melanogaster_FGF17 ---------------------MRRNLRLDWRALALLGALLSFIIAWRGLVSAMPLMAMDNNLTDSSGSTNTSTSSTSKYN STNNSNLFSNSYLQSDHSRSSLVPSAVSERSVNQPTNQSINAEFNQSLSTHPTAITSTPQTQTQTQIQSQYPSQAE---- -------------------------------------------DSDQLEEPLGFVISAMPNEHLAVLSRTERSIRHQNQQ QQKKHHHHHQQQQQQQHQQQQPMSPADNNFIGSKSKRLSNPRSSLNINSSSSNTPISNLDR-------NERSTVP----- QSHLAW--TSRKIQLYIK----------NRILQILRDGVVNGTQDENSE-------------FTILQRSTVDVGRIKLQ- -------SVATCLYLCMDACGVPYGS----------------KDFTDD----------CVFNENMGLQN----------- YNTYSSTYHSQAR----------------------R----VFYLALNGSGQPR----RTQIPASRSLGKLSTYTNAITET VPQERVEQLIAKNFGANRVKHGVRQLCDTGKPLIELIDVARFKAPPHCSSN----------------------------- --------------------TSGSSSSISSSSSSSSKSSSNSSSSYVPVSAISSLSSISNSSQSESGHISSSLSGSSNSN SSSNSSSSNSSSNSSRPSGSKANKKKKPKCKPHEQEDTHNCQKRGGAGAGALRKLGPKAKRCKELREKAAAEKRAPPNCG KKNGARKNPTEAAKAVQQRPKGNIQHGGKKKPNKAGKQRQNGGKKQQQQQQHQLQQQPLQHQAKSISGGKRKHRKLDAST TTTMATSLGTPPSSHWESSSPLPAFSLSETSDRVERNVRMSSGEEQDQDNDQDQEQSDPGEQGEEETEGDGGSLEDASYE DSSSEAQGRSGAGGDDSLYYDFLCLQLIAMVLLRKRAIL----------------------------------------- ------------------------------------------------ >Anopheles_gambiae_FGF17 ----------------------MLSGRIRRRALALLGALLLVILVWPPCCATMPKPLSVTSPQAPWDVVPPARPHPAAAV MPVPVQPSWTSGEGTFAPKRHHVPIGPGSERHQNEQHQQQQQEPAESESRKSRRVSEFYRLLRALSPATQPRPTFEPNER TQSEVSAAVQLNLPPRENSRAGRVAR------DYLIEPIDKNKSQSARPASALDLPQDNAPVRVHARFDDTNRSPALSRS RREALPANPHRHQHQLAPAGAPMNGTGVWHGRRGGGGHRHHHQHHQQQQQQNRNIESNLER-------NERSAN------ LSHITG--ATRKIQLFIK----------NRYIQLLPDGTVNGTSDDLSD-------------YTILQRTTVGIGQIKIQ- -------AVATCLFLCMDTCGSVYGS----------------KEFTDD----------CIFNEQMEQHH----------- YNTYSSTQHSNAR----------------------R----TLYLALNKTGQPR----KIQIPVNRTLGKLATYTKALTLT VAHDRVEQLISRLFGADHVRHGLNHLCETGQPLVELTAKEMRPRPVCGAQAGPMKGIAAATSTGGGGGGGGKKNGQQNTA GKDEKEGLRQKKKKKRRKCREDEVPGEHCFRPGASGAGVGGTNSGKKKAGPNQGQSRGNSSISSDSGSISPSGSNSSVGS SSAGTNQSASLNNVTGSSSSSSSSSSSSSSSISNSSSANSLIASISNGGPVRPGQPSAQLTATPNARKPKPTKKLPGGPR NGTQPPSGGNTGTTGGGPSRKPKKPNQQSQNQQQQMANGKRNGTGGNSAKPSPAKIKLVGASIVTSKLSHPKPASLMIAR TVRPTTPFPLVTARPTSGPTTVSNDLLDTSQQSDDSELDMDDALQASAELVDELDDLDEGMLTVPGHAINFVDEEDLDDM EF------------------------------------------------------------------------------ ------------------------------------------------ >Homo_sapiens_FGF8 -------------------------------------------------------------------------------- -----------------------------------------------MGSPRSALSCLLLHLLVLCLQAQEGPG------ ----------------------------------------RGPALGRELASLFRAGREPQGVS---QQVTVQSSPNFT-- --------------------------------------QHVREQSLVTDQLSRRLIRTYQL-------YSRTS------- ---------GKHVQVL------------ANKR-INAMAEDGDPF------------------AKLIVETDTFGSRVRVR- -------GAETGLYICMNKKGKLIAK---------------SNGKGKD----------CVFTEIVLENN----------- YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T RQHQREVHFMKRLPRGHHT------------------------------------------------------------- -------------------------------------------------------------------------------- ----TEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Mus_musculus_FGF8 -------------------------------------------------------------------------------- -----------------------------------------------MGSPRSALSCLLLHLLVLCLQAQVRSA------ ----------------------------------------AQKRGPGAGNPADTLGQGHEDRP---FGQRSRAGKNFTNP APNYPEEGSKEQRDSVLPK----------------VTQRHVREQSLVTDQLSRRLIRTYQL-------YSRTS------- ---------GKHVQVL------------ANKR-INAMAEDGDPF------------------AKLIVETDTFGSRVRVR- -------GAETGLYICMNKKGKLIAK---------------SNGKGKD----------CVFTEIVLENN----------- YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T RQHQREVHFMKRLPRGHHT------------------------------------------------------------- -------------------------------------------------------------------------------- ----TEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Canis_familiaris_FGF8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------------------------------------------LG---APGQSSIIMACCVFFNFLKVTVQSSPNFT-- --------------------------------------QHVREQSLVTDQLSRRLIRTYQL-------YSRTS------- ---------GKHVQVL------------ANKR-INAMAEDGDPF------------------AKLIVETDTFGSRVRVR- -------GAETGLYICMNKKGKLIAK---------------SNGKGKD----------CVFTEIVLENN----------- YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T RQHQREVHFMKRLPRGHHT------------------------------------------------------------- -------------------------------------------------------------------------------- ----TEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Bos_taurus_FGF8 -------------------------------------------------------------------------------- -----------------------------------------------MGSPRSALSCLLLHLLVLCLQAQEGPG------ ----------------------------------------GGPALGRELASLFRAGRESQGVS---QQVTVQSSPNFT-- --------------------------------------QHVREQSLVTDQLSRRLIRTYQL-------YSRTS------- ---------GKHVQVL------------ANKR-INAMAEDGDPF------------------AKLIVETDTFGSRVRVR- -------GAETGLYICMNKKGKLIAK---------------SNGKGKD----------CVFTEIVLENN----------- YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T RQHQREVHFMKRLPRGHHT------------------------------------------------------------- -------------------------------------------------------------------------------- ----TEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Loxodonta_africana_FGF8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------PI------------------AKLIVETDTFGSRVRVR- -------GAETGLYICMNKKGKLIAK---------------SNGKGKD----------CVFTEIVLENN----------- YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T RQHQREVHFMKRLPRGHHT------------------------------------------------------------- -------------------------------------------------------------------------------- ----TEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Gallus_gallus_FGF8 -------------------------------------------------------------------------------- ----------------------------------------------------------FMHLFVLCLQAQ---------- --------------------------------------------------------------------VTVQSPPNFT-- --------------------------------------QHVREQSLVTDQLSRRLVRTYQL-------YSRTS------- ---------GKHVQIL------------DNKK-INAMAEDGDVH------------------AKLIVETDTFGSRVRIK- -------GAATGFYICMNKKGKLIGK---------------SNGKGKD----------CVFTEIVLENN----------- YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T RQHQREVHFMKRLPKGHQT------------------------------------------------------------- -------------------------------------------------------------------------------- ----TEPHRRFEFLNYP-FNR-RSKRTRNSSARVRP-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Anolis_carolinensis_FGF8 -------------------------------------------------------------------------------- -----------------------------------------------MNFFSSIFSYLVLHLFAFCLQAQ---------- --------------------------------------------------------------------VTVQSPPNFT-- --------------------------------------QHVREQSLVTDQLSRRLVRTYQL-------YSRTS------- ---------GKHVQIL------------DNKK-INAMAEDGDAH------------------AKLIVETDTFGSRVRIK- -------GAETGFYICMNKKGKLIGK---------------SNGKGKD----------CVFTEIVLENN----------- YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T RQHQREVHFMKRLPKGHQT------------------------------------------------------------- -------------------------------------------------------------------------------- ----TEPHRRFEFLNYP-FNR-RSKRTRNSSPKPSP-------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Xenopus_tropicalis_FGF8 -------------------------------------------------------------------------------- -----------------------------------------------MSYITSILGYLLLHLFVICLQAQARAG------ ---------------------------------------RIG----SPTEREGIRRESEAPRGEVSTQVTVQSPPNFT-- --------------------------------------QHVREQSLVTDQLSRRLIRTYQL-------YSRTS------- ---------GKHVQIL------------GNKK-INAMAEDGDPH------------------AKLIVETDTFGSRVRIK- -------GAETGYYICMNKKGKLIGK---------------TSGRGKD----------CVFSEIVLENN----------- YTALQNVKYE------------------------------GWYMAFTRRGRPR----KGSK------------------T RQHQREVHFMKRLPKGHHT------------------------------------------------------------- -------------------------------------------------------------------------------- ----TEPHKRFEFINYP-FNR-RSKRTRYSSSR----------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Danio_rerio_FGF8_a -------------------------------------------------------------------------------- -----------------------------------------------MRLIPSRLSYLFLHLFAFCYY------------ ------------------------------------------------------------------AQVTIQSPPNFT-- --------------------------------------QHVSEQSKVTDRVSRRLIRTYQL-------YSRTS------- ---------GKHVQVL------------ANKK-INAMAEDGDVH------------------AKLIVETDTFGSRVRIK- -------GAETGFYICMNRRGKLIGK---------------KNGLGKD----------CIFTEIVLENN----------- YTALQNVKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T RQHQREVHFMKRLPKGHQ-------------------------------------------------------------- -------------------------------------------------------------------------------- ----IAEHRPFDFINYPFNRRTKRTRYSGER------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Takifugu_rubripes_FGF8_a -------------------------------------------------------------------------------- -----------------------------------------------MRPIPSRLSYLFLHLFAFCYYAQEAFD------ ------------------------------------------PTWREFSMELAAIFIRDHTPQSIVAQVTNQSPPNFT-- --------------------------------------QHVSEQSKVTDHVSRRLIRVYQL-------YSRTS------- ---------GKHVQVL------------PNKK-INAMADDGDVH------------------AKLIVETDTFGSRVRIK- -------GAETGFYICMNKRGKLVGK---------------KNGQGRD----------CIFTEIVLENN----------- YTALRNARYE------------------------------GWYMAFTRRGRPR----KGSR------------------T RQHQREVHFMKRLPKGQQPVH----------------------------------------------------------- -------------------------------------------------------------------------------- ----PSHHRPFDFIHYPFNQRTKRTRHSSERPNPR--------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Tetraodon_nigroviridis_FGF8_a -------------------------------------------------------------------------------- -----------------------------------------------MQTISSRLSYLFLHLFAFCYY------------ ------------------------------------------------------------------AQVTNQSSPNFT-- --------------------------------------QHVSEQSKVTDHVSRR-IRIYQL-------YSRTS------- ---------GKHVQVL------------PNKK-INAMADDGDVHV-----------------AKLIVETDTFGSRVRIK- -------GAETGFYICMNKRGKLIGK---------------KNGQGRD----------CIFTEIVLENN----------- YTALRNARYE------------------------------GWYMAFTRRGRPR----KGSR------------------T RQHQREVHFMKRLPKGQQPVH----------------------------------------------------------- -------------------------------------------------------------------------------- ----PSHHRPFDFIHYPFNQRTKRTRYSSES------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Gasterosteus_aculeatus_FGF8_a -------------------------------------------------------------------------------- ---------------------------------------------RAICFMLPRLN-KCLHLFSFCYF------------ ------------------------------------------------------------------AQVTNQSPPNFT-- --------------------------------------QHVSEQSKVTDRVSRRLIRVYQL-------YSRTS------- ---------GKHVQVL------------PNKK-INAMADDGDVH------------------AKLIVETDTFGSRVRIK- -------GAETGFYICMNKKGKLIGK---------------NNGHGRD----------CIFTEIVLENN----------- YTALRNARYE------------------------------SWYMAFTRRGRPR----KGSR------------------T RQHQREVHFMKRLPKGQQPAH----------------------------------------------------------- -------------------------------------------------------------------------------- ----TSHHRPFDFVHYPFRQRTKRTRYSSER------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Oryzias_latipes_FGF8_a -------------------------------------------------------------------------------- ----------------------------------------------FTSLIPPVIGHGFLHLFAFCHY------------ ------------------------------------------------------------------AQVTNQSSPNFT-- --------------------------------------QHVSEQSRVTDHVSRRLIRVYQL-------YSRTS------- ---------GKHVQVL------------SNKK-INAMAEDGDVH------------------AKLIVETDTFGSQVRIK- -------GAQTGLYICMNKKGKLIGK---------------KNGQSRD----------CIFTEIVLENN----------- YTALRNAHYN------------------------------DWYMAFTRRGRPR----RGSQ------------------T RQHQREVHFMKRLPRGQQVIH----------------------------------------------------------- -------------------------------------------------------------------------------- ----SSQHRPFDFIHS-FSQRTKRTRYSSER------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------------------------------------------ >Ciona_savignyi_FGF8 -------------------------------------------------------------------------------- ---------------------------------------------MRPKITCENLYATICRFLLCVIIFGDETN------ -------------------------------------------------------------------AISNKRIED---- --------------------------------------YITMALSRS--QTTASTRRYYEI-------YAKAT------- ---------SSRVQIL------------GKRVN--AKGVRGNKY------------------SKMAILSTSFGGRIMIQ- -------GVETGRVLCMNRKGRLVGKV-------------LRRAKHDLK---------CQFNDLMMPNL----------- FDYFTNVAHP------------------------------KWYVAFNSHGRPK----KGPT------------------T KLGQVETMFLKRPIETFGYPSGAPVTDDSRFGEIARAMIKQIRGHPRRKHSR---------------------------- ----------AFTGSNRLMRDSPSAGEVMFPDAN--SPSLPPDVEAEMARRRSVLSDVQRQLSLDVTIPAHAPTVSATGP PDWSTRVQVRYRGQRKRNKRKRKNKKLRKVRKKPMPTVPTNVMDTDFDIQATTRPHLPTARPFAGLVRNVSGLPTFPSAV RTTESRHAGRRHGTKKRNKKRKSSLRKRGRRRRTRMRNRNSVNT------------------------------------ -------------------------------------------------------------------------------- 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