>Homo_sapiens_EIF4EBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSGGSSC-------SQTP--SRAIPA-TRRVVLGDGVQLPPGDYSTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLMECRNS--------PV---------------TKTPPRDLPTIPGVTSPS------SDEPPMEASQSHLRN------ ------------------------------------------------------SPEDKRA------------------- -------------------------------------------------------------------------------- ----------------------------------------GGEESQFEMDI----------------------------- ---------------- >Gorilla_gorilla_EIF4EBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSGGSSC-------SQTP--SRAIPA-TRRVVLGDGVQLPPGDYSTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLMECRNS--------PV---------------TKTPPRDLPTIPGVTSPS------SDEPPMEASQSHLRN------ ------------------------------------------------------SPEDKRA------------------- -------------------------------------------------------------------------------- ----------------------------------------GGEESQFEMDI----------------------------- ---------------- >Callithrix_jacchus_EIF4EBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSGGSSC-------SQTP--SRAIPA-TRRVVLGDGVQLPPGDYSTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLMECRNS--------PV---------------TKTPPRDLPAIPGVTSPA------GDEPPTEASQSHLRN------ ------------------------------------------------------SPEDKRA------------------- -------------------------------------------------------------------------------- ----------------------------------------GSEESQFEMDI----------------------------- ---------------- >Mus_musculus_EIF4EBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSAGSSC-------SQTP--SRAIP--TRRVALGDGVQLPPGDYSTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLMECRNS--------PV---------------AKTPPKDLPAIPGVTSPT------SDEPPMQASQSQLPS------ ------------------------------------------------------SPEDKRA------------------- -------------------------------------------------------------------------------- ----------------------------------------GGEESQFEMDI----------------------------- ---------------- >Rattus_norvegicus_EIF4EBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSAGSSC-------SQTP--SRAIP--TRRVALGDGVQLPPGDYSTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLMECRNS--------PV---------------AKTPPKDLPTIPGVTSPT------SDEPPMQASQSHLHS------ ------------------------------------------------------SPEDKRA------------------- -------------------------------------------------------------------------------- ----------------------------------------GGEESQFEMDI----------------------------- ---------------- >Oryctolagus_cuniculus_EIF4EBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------CLGAAGC-------SQTP--SRAIPT-TRRVVLADGVQLPPGDYSTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLMECRNS--------PV---------------AQTPPKDLPTIPGVTSPA------SDEPPTEASQSHLRN------ ------------------------------------------------------SPEDKRA------------------- -------------------------------------------------------------------------------- ----------------------------------------GGEESQFEMDI----------------------------- ---------------- >Dasypus_novemcinctus_EIF4EBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSGGSSC-------GHTP--SRAIPT-TRRVVLGEGVQLPPGDYSTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLMECRNS--------PV---------------AKTPPRDLPTIPGVTSPA------SEEPPAEASQSHLRG------ ------------------------------------------------------RPEDKPA------------------- -------------------------------------------------------------------------------- ----------------------------------------GGEWPGWARL------------------------------ ---------------- >Monodelphis_domestica_EIF4EBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSAGGSC-------GQTP--SRAIPA-TRRVVLSDGVQLPPGDYSTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLMECRNS--------PV---------------AKTPPRDLPAIPGVTSPA------SEEAAPEMNPNHLAN------ ------------------------------------------------------SHEDKPG------------------- -------------------------------------------------------------------------------- ----------------------------------------SNEESQFEMDI----------------------------- ---------------- >Gallus_gallus_EIF4EBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSGRCCQ-------GQTP--SRDIPGPGKRLALPDGAPLPPGDYSTTP-------------------- ----GGTVFGTTPG-----------------------------------------------------------GTRIIYD RKFLMECRNS--------PV---------------AKTPPSDLPDIPGVTSPI------VEELKIEN--NHVQN------ ------------------------------------------------------YDEKAN-------------------- -------------------------------------------------------------------------------- ----------------------------------------VGEEEQFDMDI----------------------------- ---------------- >Taeniopygia_guttata_EIF4EBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSGRCCH-------GQTP--NRDIPGPGKCLALPDEAPLPPGDYSTTP-------------------- ----GGTVFGTTPG-----------------------------------------------------------GTRIIYD RKFLMECRNS--------PG---------------AKTPPSDLPDIPGVTSPS------VEELKLEN--HHVQS------ ------------------------------------------------------CEEKVSA------------------- -------------------------------------------------------------------------------- ----------------------------------------AGEEEQFDMDI----------------------------- ---------------- >Anolis_carolinensis_EIF4EBP1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSSAATY-------FRSP--PALIP--AKRLHLPEGVALPPGDYSTTP-------------------- ----GGTLFGTTPG-----------------------------------------------------------GTRIIYD RKFLMECRNS--------PV---------------AKTPPCDLPDIPGVTCPN------VDEVRNES--SLVHA------ ------------------------------------------------------DVEKLG-------------------- -------------------------------------------------------------------------------- ----------------------------------------LGEEAQFDMDI----------------------------- ---------------- >Danio_rerio_EIF4EBP1_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSMGS---------QKTT--SQAIPT-TRRVILNDAAHLP-HDYSTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDCRSS--------PL---------------ARTPPCCLPDIPGVTSPP--SVTVNNEKAYPKPTVNNNSIS---- ------------------------------------------------------PPVDKS-------------------- -------------------------------------------------------------------------------- ----------------------------------------TGEDAQFEMDI----------------------------- ---------------- >Oryzias_latipes_EIF4EBP1_b -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSAGG---------QTTT--SLEIPA-VRRVAIHDAAHMP-HEYSTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYE RKFLLQCRTS--------PL---------------ARTPPNNLPDIPGVTRPLNSDSSHDTKNPVEAPTTNNHD-T---- ------------------------------------------------------DVQTEEG------------------- -------------------------------------------------------------------------------- ----------------------------------------TCEDAQFEMDI----------------------------- ---------------- >Homo_sapiens_EIF4EBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MSSSAGSGH-------QPSQ--SRAIPT--RTVAISDAAQLP-HDYCTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDRRNS--------PM---------------AQTPPCHLPNIPGVTSPG------TLIEDSKVEVNNLNNLN---- ------------------------------------------------------NHDRKHA------------------- -------------------------------------------------------------------------------- ----------------------------------------VGDDAQFEMDI----------------------------- ---------------- >Macaca_mulatta_EIF4EBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MSSSAGSGH-------QPSQ--SRAIPT--RTVAISDAAQLP-HDYCTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDRRNS--------PM---------------AQTPPCHLPNIPGVTSPG------TLIEDSKVEVNNLNNLN---- ------------------------------------------------------NHDRKHA------------------- -------------------------------------------------------------------------------- ----------------------------------------VGDDAQFEMDI----------------------------- ---------------- >Mus_musculus_EIF4EBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MSASAGGSH-------QPSQ--SRAIPT--RTVAISDAAQLP-QDYCTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDRRNS--------PM---------------AQTPPCHLPNIPGVTSPG------ALIEDSKVEVNNLNNLN---- ------------------------------------------------------NHDRKHA------------------- -------------------------------------------------------------------------------- ----------------------------------------VGDEAQFEMDI----------------------------- ---------------- >Rattus_norvegicus_EIF4EBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MSASAGGGH-------QPSQ--SRAIPT--RTVAISDAAQLP-QDYCTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDRRNS--------PM---------------AQTPPCHLPNIPGVTSPG------ALMEDSKVEVNNLNNLN---- ------------------------------------------------------NHDRKHA------------------- -------------------------------------------------------------------------------- ----------------------------------------VGDEAQFEMDI----------------------------- ---------------- >Anolis_carolinensis_EIF4EBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MSSSSSRNSSGGVGPLHPSQ--SRAIPT--RTVPISDSSQLP-HDYCTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDRRNS--------PM---------------AQTPPCHLPNIPGVTSPG------SMTEDSKVEVNNLN------- ------------------------------------------------------NHDGKAI------------------- -------------------------------------------------------------------------------- ----------------------------------------IGDDAQFEMDI----------------------------- ---------------- >Xenopus_tropicalis_EIF4EBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------QARNMSAGH-------QHSQ--SRAIPT--RTIPISDSSQLP-HDYCTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDRRNS--------PL---------------AQTPPRRLPDIPGVTSPN------TAVEESKVETNNLN------- ------------------------------------------------------NHDTKTA------------------- -------------------------------------------------------------------------------- ----------------------------------------AGDDSQFEMDI----------------------------- ---------------- >Danio_rerio_EIF4EBP2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------MSSSR-----------QLSE--SRAIPT--RTVLINDSTQLP-HDYCTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDRRNS--------PI---------------AQTPPAHLPVIPGVTGKN------ILNEIKRNEANN---IN---- ------------------------------------------------------NHDAKPG------------------- -------------------------------------------------------------------------------- ----------------------------------------QGEDAQFEMDI----------------------------- ---------------- >Takifugu_rubripes_EIF4EBP2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------ALKMSR-----------QLSE--SRAIPT--RTVLINDTTQLP-HDYCTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDRRNS--------PI---------------AQTPPAHLPVIPGVTSQN------VVRENKKNEANNR--IN---- ------------------------------------------------------KHDDKSA------------------- -------------------------------------------------------------------------------- ----------------------------------------NGDDAQFEMDI----------------------------- ---------------- >Tetraodon_nigroviridis_EIF4EBP2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------VDMSAGG---------QATR--SREIPA-VRRVAIHDTAHMP-QDYSTTP-------------------- ----GGTVFSTTPG-----------------------------------------------------------GTRIIYD RKFLLQCRSS--------PL---------------TRTPPN-LPDIPGVTRSVKRTPSCDSPQPHETPSTNSEH-S---- ------------------------------------------------------VHTEEHA------------------- -------------------------------------------------------------------------------- ----------------------------------------ALDDAQFEIDI----------------------------- ---------------- >Gasterosteus_aculeatus_EIF4EBP2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------RRRKMSTSR-----------QLSE--CRAIPT--RTVLINDTTQLP-HDYCTTP-------------------- ----GGTLFSTTPGA----------------------------------------------------------GTRIIYD RKFLLDRRNS--------PI---------------AQTPPAHLPVIPGVTSQN------VLRENKKNEANKH--II---- ------------------------------------------------------KHDGKPA------------------- -------------------------------------------------------------------------------- ----------------------------------------TGDDAQFEMDI----------------------------- ---------------- >Oryzias_latipes_EIF4EBP2_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------EKMSTEC---------QKTT--AKAIPS-TKRVTINNADHMP-HDYSTTP-------------------- ----GGTLFSTTPGET---------------------------------------------------------GTRIIYD RKFLLECRSS--------PL---------------AKTPPRGLPSIPGVTSPP--TKEFN-KKTLNGEVVNID--T---- ------------------------------------------------------PAADSSS------------------- -------------------------------------------------------------------------------- ----------------------------------------AGDDAQFEMDI----------------------------- ---------------- >Ciona_savignyi_EIF4EBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MSE--SKGIPI--RHIRLNHLSELP-NDYGTTP-------------------- ----GGTLYSTTPG-----------------------------------------------------------GTRIIYD RSFLLKCRSS--------PM---------------ANTPPSNLPDIPGVTSPDKSPNRQITKIVEEKEVTNGKDKPKENG GILPNWSMHGPHVPAFHPCPANGPLQQYRQRSLQQQRQAMLDKALDPNLVYTISGPVGQNVNPMVPPDYISYPPPPRSPQ AQFYDSNNNLQNNAGDGLWQMNGMPMLPQSNKPYPMSQLTSWRRMKVNQAITHAFTQSNQPFPNASQSQGAAVNFANQFS SCSCRNLHNKVTLYVPLTAICPAIATNRRWWMKIQTLSHTHKDEEQFDMEI----------------------------- ---------------- >Strongylocentrotus_purpuratus_EIF4EBP2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSAPAASR------QLSA--GRDIPS--KRVTVNDPSQLP-HDYSTTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RNFLLNMRNS--------PL---------------SQTPPKNLPSIPGVTCPE------VG--AGAEKPNGAR------- ------------------------------------------------------KTATKT-------------------- -------------------------------------------------------------------------------- ----------------------------------------DPAEDQFQMDI----------------------------- ---------------- >Homo_sapiens_EIF4EBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSTST---------------SCPIPG--------GRDQLP-DCYSTTP-------------------- ----GGTLYATTPG-----------------------------------------------------------GTRIIYD RKFLLECKNS--------PI---------------ARTPPCCLPQIPGVTTPP---------TAPLSKLEELKEQ----- ------------------------------------------------------ETEEE--------------------- -------------------------------------------------------------------------------- ----------------------------------------IPDDAQFEMDI----------------------------- ---------------- >Pan_troglodytes_EIF4EBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSTST---------------SCPIPG--------GRDQLP-DCYSTTP-------------------- ----GGTLYATTPG-----------------------------------------------------------GTRIIYD RKFLLECKNS--------PI---------------ARTPPCCLPQIPGVTTPP---------TAPLSKLEELKEQ----- ------------------------------------------------------ETEEE--------------------- -------------------------------------------------------------------------------- ----------------------------------------IPDDAQFEMDI----------------------------- ---------------- >Macaca_mulatta_EIF4EBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSTST---------------SCPIPW--------GRDQLP-DCYSTTP-------------------- ----GGTLYATTPG-----------------------------------------------------------GTRIIYD RNFLLECKNS--------PI---------------ARTPPCCLPQIPGVTTPP---------TAPLSKLEELKEQ----- ------------------------------------------------------ETEEE--------------------- -------------------------------------------------------------------------------- ----------------------------------------IPDDAQFEMDISSSCR------------------------ ---------------- >Mus_musculus_EIF4EBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSSST---------------SCPIPG--------CRDQLP-DGYSTTP-------------------- ----GGTLYATTPG-----------------------------------------------------------GTRIIYD RKFLLECKNS--------PI---------------ARTPPCCLPQIPGVTTLP---------AVPPSKLELLKEQK---- ------------------------------------------------------QTEVE--------------------- -------------------------------------------------------------------------------- ----------------------------------------ITDDEQFEMDM----------------------------- ---------------- >Rattus_norvegicus_EIF4EBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSTST---------------SCPIPG--------SWDQLP-DGYSTTP-------------------- ----GGTLYATTPG-----------------------------------------------------------GTRIIYD RKFLLECKNS--------PI---------------ARTPPCCLPQIPGVTIPP---------TVPPFKLELLKEQK---- ------------------------------------------------------QTEEE--------------------- -------------------------------------------------------------------------------- ----------------------------------------ITDDEQFEMDM----------------------------- ---------------- >Danio_rerio_EIF4EBP3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSTNTQQ---------SK--SCPIPT--RVLHLKDWSQLP-DCYSQTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDCRNS--------PI---------------ARTPPCCLPQIPGVTIPS---------LHPVSKLQELKEE----- -------------------------------------------------------LEEE--------------------- -------------------------------------------------------------------------------- -------------------------------------KELAADDSQFEMDI----------------------------- ---------------- >Takifugu_rubripes_EIF4EBP3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------TEASMSTGKGE---------VK--SCPIPT--RVLTLKDWSQLP-DCYSQTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDCRNS--------PL---------------ARTPPCCLPQIPGVTVPA---------THPIGKLQDLKDQ----- -------------------------------------------------------TGEKYFR------------------ -------------------------------------------------------------------------------- -------------------------------------NHACSDENQFEMDI----------------------------- ---------------- >Tetraodon_nigroviridis_EIF4EBP3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -----------SMSTGKGE---------VK--SCPIPT--RVLTLKDWSQLP-DCYSQTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDCRNS--------PL---------------ARTPPCCLPQIPGVTVPA---------THPVGKLQDLKEE----- -------------------------------------------------------AEEE--------------------- -------------------------------------------------------------------------------- -------------------------------------EKETADESQFEMDI----------------------------- ---------------- >Gasterosteus_aculeatus_EIF4EBP3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ----------LSMSTGTNE---------AK--SCPIPT--RVLTLKDWSQLP-DCYSQTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLDCRNS--------PL---------------ARTPPCCLPQIPGVTVPA---------THPMGKLQDLKEE----- -------------------------------------------------------AEEE--------------------- -------------------------------------------------------------------------------- -------------------------------------EKDVPDDNQFEMDI----------------------------- ---------------- >Oryzias_latipes_EIF4EBP3_a -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- --------QQASMSTGAKQ---------AK--SCPIPT--RVLTLKDWSQLP-DCYSQTP-------------------- ----GGTLFSTTPG-----------------------------------------------------------GTRIIYD RKFLLECRNS--------PL---------------ARTPPCCLPQIPGVTIPA---------THSVGKLQDLKEE----- -------------------------------------------------------EEKD--------------------- -------------------------------------------------------------------------------- ---------------------------------------VAADDSQFEMDI----------------------------- ---------------- >Ciona_intestinalis_EIF4EBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ---------------------------MSE--SKGIPI--RHIRLNHLSELP-NDYGTTP-------------------- ----GGTFYSTTPG-----------------------------------------------------------GTRIIYD RSFLLKCRSS--------PM---------------ANTPPSNLPDIPGVTSPDKSPTRQITKIKEEEEIAN-KD------ ------------------------------------------------------GSNGK--------------------- ----------EN--GD---------------------------------------------------------------- ---------------------------------------SHKDEEQFDLEI----------------------------- ---------------- >Amphimedon_queenslandica_EIF4EBP3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- ------------MSEEAKKGPTGLDRQSSN--SLDIPS--RTVLVKDASELP-SSYCMTP-------------------- ----GGTMYSTTPG-----------------------------------------------------------GTRIIYD RKMLLQLRDS--------PY---------------SRTPPTRLPPIP--------------DIIAEGSVAVP---QG--- ------------------------------------------------TKSPLAVPSENQP------------------- -------------------------------------------------------------------------------- ----------------------------------------NEPEVPFPFEIET--------------------------- ----------------