>Homo sapiens SP1
---------MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGG-AFSQARSSSTGSSSSTGGGG-QESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLT--ATQLSQGANGWQIISSSSGATPTSKEQSGSSTNGSNG---------------SESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQV--QQDGS---GQIQIIPGAN--QQIITNRGSGGN-IIAAMPNLLQQAVPLQ--GLANNVLSG-QTQYVTNVPVALNG-NITLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPVTSGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSS-GTNSQGQTPQRVSGLQG-----------SDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQ--QQILIQP-QLVQGGQALQALQA---APLSGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQ-------VQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTS--------------------GIQVHPIQGLPLAIAN------------------------APGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTRREACTCPYCKDSEGR--GSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSYCGKRFTRSDELQRHKRTHTGEKK--------------------FACP--------------ECPKRFMRSDHLSKHIKTHQNKKGGPG--VALSVGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINISGNGF-
>Mus musculus Sp1
---------MSDQDHSMDEVTAVVKIEKDVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLT--AAQLSQGANGWQIISSSSGATPTSKEQSGNSTNGS------------------ESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQV--QQDGS---GQIQIIPGAN--QQIIPNRGSGGN-IIAAMPNLLQQAVPLQ--GLANNVLSG-QTQYVTNVPVALNG-NITLLPVNSVSAATLTPSSQAGTISSSGSQESSSQPVTSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSS-GTSSQGQTPQRVGGLQG-----------SDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQ--QQILIQP-QLVQGGQALQALQA---APLSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQ-------VQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTS--------------------GIQVHQLPGLPLAIAN------------------------TPGDHGTQLGLHGSGGDGIHDETAGGE-GENSSDLQPQAGRRTRREACTCPYCKDSEGR--ASGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKK--------------------FACP--------------ECPKRFMRSDHLSKHIKTHQNKKGGPG--VALSVGTLPLDSGAGSEG--TATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSINISGNGF-
>Rattus norvegicus Sp1
---------FLDQDHSMDEVTA-VKIEKGVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLT--ATQLSQGANGWQIISSSSGATPTSKEQSGNSTNGSNG---------------SESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQV--QQDGS---GQIQIIPGAN--QQIITNRGSGGN-IIAAMPNLLQQAVPLQ--GLANNVLSG-QTQYVTNVPVALNG-NITLLPVNSVSAATLTPSSQAGTISSSGSQESGSQPVTSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSS-GTSSQGQTSQRVGGLQG-----------SDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQ--QQILIQP-QLVQGGQALQALQA---APLSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQ-------VQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTS--------------------GIQVHQLPGLPLAIAN------------------------TPGDHGAQLGLHGPGGDGIHDETAGGEEGENSPDPQPQAGRRTRREACTCPYCKDSEGR--GSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKK--------------------FACP--------------ECPKRFMRSDHLSKHIKTHQNKKGGPG--VALSVGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSINISGNGF-
>Xenopus tropicalis Sp1
---------MSDQEHTSDDMPTIK--SENRTGGG-------------------YIQ------KGQDSQPSPLALLAATCSRIEPP-ENGNGNSQ--QQGAT-ELDLS--TAQLAQTANGWQIISTAG---SASKDQAGGDAS----------------------SKNRPIAPGQFVVSTPS-VQNQQVLASLQGVMPNIQYQVIPQFQTVDGQQLQFTTAPAQVSVQQDAS---GQFQIIPATN--QQIITTNRTGTG-NILAMPNLLQQAVPIQGMGLTNNVLSG-QTQYLTNVPVALNG-NITLLPVN---AASLTPTSQSVTLSG--TQENNSQPVTSGVAISSSQLAS-QANSGAYFTNANSFSTTTTPSNVSLMNCSSAGSTPGSNVQVQTSQR-----S-----------TGQLSLLTDSVQ--QGNGNMQKDGDQNQQ-----QQILIQP-QIVQSGQTIQALQA---AQLSGQAFSTQAISQDALQNLQIQTVPNTGPIIIRTPAVGPNGQVTWQTIQLQNLQ-------VQNPQAQTITLAPMQGVSLGQSGSTNT-------LTSMPAGTVTVNAAQLSSMPGLQTINLGALGAS--------------------GIQVHQLQGVPLTITN------------------------ATGDI--------ASG-------------------------TIR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>Gallus gallus Sp1
---------MSDSE-SPEEMAAVKGTPERGEGDG-------------------SSDSSSPAGEGQESQPSPLALLAATCSRIESPNENSNSSQG--QQGGSGELDLTAAAAQIAQSANGWQIISTGSTTPTPSKEQGSNGSNGD-------------------PSKSRPVSTGPYVVTAASNLQNQQVLTGLPGVIPNIQYQVIPQFQTIDGQQLQFATTPAQVNVQQDAS---GQLQIIPGTN--QQIITS-RAGTG-NLIAMPNLLQQAVPIQGVGLANNTLSG-QTQYVANVPVALNG-NITLLPVNSV-AASLAPTSQTVTLSGSGSPDSSSQPTTSGAAISSSNIATSHASSGSFFTNANSYSTTTTTSNMGIMNFSSS-STVGTNVQVQTPQRAP---S-----------TDSLQSQVSGVA--LQPG-QQKEGDQSQQSQQQQQQILIQP-QLVQGGQTIQALQT---APLSGQTFATQAISQDALQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTIQLQNLQ-------VQNPQAQTITLAPMQGVSLGQTGSTSTTLT---PIASLPSGTVTVNAAQLSSMPGLQTINLSALGAS--------------------GIQVHQLQGLPLAIAN------------------------ATGEHGTQLGLHGASGDGLGDDSAAVEEGETSPDPQPQQGRKVRREACTCPYCKDSEGR--SSGDPGKKKQHICHIPGCGKVYGKTSHLRAHLRWHTGERPFICGWMLCGKRFTRSDELQRHKRTHTGEKK--------------------FACP--------------ECPKRFMRSDHLSKHIKTHQNKKGGAANSVAMNVSAVPMDTGASSEGSGGPTPSALIATNMVAMEAICPDGIARLASSGINVMQVADLQSINISGNGF-
>Tetraodon nigroviridis SP1
-------------------------------------------------------------------------------------------------------------------------------------------------------------------MSWLRLHQCQ-----------GEQVLTTISGVMPNIQYQVIPSFQTVDGQPLQLAHAQQESAGPAAAAPG-QQFQIVSSPNGQQIIAATNRAGAAGNIITMPSLLQGAIPIQNISLGNSVLKN-QPQFLANMPVSLNG-NITLLPIS--------TAASSGTAGDANGGDTARNPITQQQ-PASSNSATGYATSVSTAQTSTSYGLTQTQNSNGVMTGTFQQNAATLGVPIQPENR---------------------------------------EGQQPQQ-------ILIQPQQVLPGGATLQGIQAGTVATAGGQVFAAPTISQEGLQNLQI--MPNAGPILLHT--VGPNGQVSWQTIQIQ------------NPAGPQITLAPVQ--TLPQLGQGQG---------AAAASGVSVNAVQI---PGIQTINLNTLGGS--------------------GLQ---LQTVPLTLAN------------------------AAG-----------------------------------------------------------------------------------------------------------------------------EKR--------------------FACP--------------ECPKRFMRSDHLSKHIKTHMNKKVQAASASGPAGSTDSSSPAIVGTKVETGAAATADQHTIVTMETLSAESIARLASSGINMMQV-DLHQMNGNNY---
>Takifugu rubripes SP1
-------------------------------------------------------------------QPSPLALLAATCSRIDTPGESDSPSDQ---QNQQQQLELN--QGAFTSNSNGWQVIPLNIQASSGANTATTDSSAVMAGGDAGKSRQLLSPSVAVGSTQGQQHQPQQYVVAQAPSMPGQQVLTTISGVMPNIQYQVIPQFQTIDGQPLQLAHAQQESAVPAAAAPG-QQFQIVSSPNGQQLIAATNRAGTAGNIITMPSLIQGAIPIQNISLGNGMLKN-QPQFLANMPVSLNG-NITLLPIS--------TATG-GTGADTNGGDTARNQVTQQQQPVSSTGSTGYVTSVSTAQTATSYGLTQTQNSNGVMT--FQQNTANLGVPIQPESR---------------------------------------EGQPQQQ-------ILIQPQQVIQGGATLQPIQAGTVATAGGQVFAAPTISQEGLQNLQI--MPNTGSILLHT--VGPNGQVSWQTIQIQ------------NPAGPQITLAPMQ--TLPQLGQAQG---------AAAAAGVSVNAVQI---PGIQTINLNTLGGS--------------------GLQ---LQTVPITLAN------------------------TAGDHQNLHSGGDTLDDGTAIDEGDMS--------PPPQGRRNRREACTCPFCKDGEGR-----DPTKKKQHICHISGCGKIYGKTSHLRAHLRWHTGERPFVCSWSFCGKRFTRSDELQRHKRTHTGEKR--------------------FACP--------------ECPKRFMRSDHLSKHIKTHTNKKVPAASASGIAGSSD---PTAVGTKVEQGAGAASDQHTIVTMETLSAESIARLASSGLNMMQV-DLHPMN-------
>Homo sapiens SP4
---------------MATEGGKTSEPENNN---KKPKTSGSQDSQPSPLALLAATCSKIG--TPGENQATGQQQIIIDPS---------QGLVQLQNQ------PQQLELVTTQLAGNAWQLVASTPPASKENNVSQP----ASSSSSSSSS---------NNGSASPTKTKSGNS--STPGQFQVIQVQ---NPSGSVQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQ--IQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGG-VTLALPVIN----NVAAGGGTGQVGQP-AATADSGTSNGNQLVSTPTNTTTSASTMPESPSSST--TCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIEESQTP---AATESEAQSSSQLQPNGMQNAQDQSNSLQQVQI--VGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQ-LQAVN-PTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGG-TTLAQIA-------PVAVAGAPITLNTAQLASVPNLQTVSVANLGAAG--------VQVQGVPVTITSVAGQQQGQDGVKVQQAT-------------------IAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDQEVQPGKRLRRVACSCPNCREGEGR--GSNEPGKKKQHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKR--------------------FECP--------------ECSKRFMRSDHLSKHVKTHQNK-KGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNP------ATPNVSTNMEEF------------------
>Mus musculus SP4
VADQKKEEEEEAAAAMATEGGKTSEPENNN---KKPKTSGSQDSQPSPLALLAATCSKIG--TPGENQATGQQQIIIDPS---------QGLVQLQNQ------PQQLELVTTQLAGNAWQLVASTPPASKENNVSQP----ASSSSSSSSS---------NNGSSSPTKTKSGNP--STPNQFQVIQVQ---NPSGSVQYQVIPQLQTVEGQPIQINPTSSSSLHDSQGQ--IQLISA---------------------------VPLQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGG-VTLALPVIN----NVTAGGGTGQVGQP-TTTTDSGTSNGNQLVSTPTTSTAPASTMPESPSSST--TCTTTASTTLTSSDTLVSSADTGQYASTSASSSERTIEEPQTP---AATESEAQSSSQLQSNGIQNAQDQSNSLQQVQI--VGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQ-LQAVN-PTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGG-TTLAQIA-------PVAVAGAPITLNTAQLASVPNLQTVSVANLGAAG--------VQVQGVPVTITSVAGQQQGQDGVKVQQAT-------------------IAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDAEVQPGKRLRRVACSCPNCREGEGR--GSSEPGKKKQHVCHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKR--------------------FECP--------------ECSKRFMRSDHLSKHVKTHQNK-KGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNP------ATPNVSTNMEEF------------------
>Rattus norvegicus SP4
MSDQKKEEEEEAAAAMATEGGKTSEPENNN---KKPKTSGSQDSQPSPLALLAATCSKIG--TPGENQATGQQQIIIDPS---------QGLVQLQNQ------PQQLELVTTQLAGNAWQLVASTPPASKENNVSQP----ASSSSSSSSS---------NNGSSSPTKTKSGNP--STPNQFQVIQVQ---NPSGSVQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQ--IQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGG-VTLALPVIN----NVTAGGGTGQVGQPTTTTTDSGTSNGNQLVSTPTTSTAPASTMPESPSSST--TCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIEEPQTP---AATESEAQSSSQLQSNGIQNAQDQSNSLQQVQI--VGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQ-LQAVN-PTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGG-TTLAQIA-------PVAVAGAPITLNTAQLASVPNLQTVSVANLGAAG--------VQVQGVPVTITSVAGQQQGQDGVKVQQAT-------------------IAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDAEVQPGKRLRRVACSCPNCREGEGR--GSSEPGKKKQHVCHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKR--------------------FECP--------------ECSKRFMRSDHLSKHVKTHQNK-KGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNP------ATPNVSTNMEEF------------------
>Xenopus tropicalis Sp4
---------------MASEGGKASESENKK----KGKASGSQDSQPSPLALLAATCSKIG--TTGENQGAGQQQIIIDPS---------QGLVQLQNQ------PQQLELVTTQLAGSAWQIVAAAPPVSKENNITQQGVAIAASTAASSSI---------NSENASPTKSKPSNA-ATAPGQFQVIQVQ---TPGGNVQYQVIPQIQTVEGQHIQISPGNTTALQDLQGQ--IQFIPAGNNQAIITAGNRTASGNIIAQNLANQTVPVQIRPGVSIPLQLQTIPGAPAQVVTTLPINIGG-VTLALPVIN----SMPAGGGSAQIVQP----TDGGVSNGNQLLSTPITT-SSVSTMPESPSSSSSSTCTTTVSATLTSSDTLVSSAETNQYTSTSAS-AERNTEESPS----SVTDGEAQSSNQLQSNGLQNMSEQSNSLQQVQI--VGQPVLQQIQIQQPQQQIIQAIPQQSFQLQSGQTIQTLQQQQLQNVQ-LQALS-PTQVLIRAPTLTPSGQISWQTVQVQNIQSLQNLQVQNPGLPQQLTLTPVSTSSG-TTIAQIA-------PVTVAGTPITLNAAHFTSVPNLQTVSVANLGAAG--------VQVQGVPVTITSVGGQQQGAEGVKVQQAT-------------------IAPVTVAVGGIANATIGAVSPDQLTQVQLQQSQPSSDQEVQTGKRLRRVACSCPNCREGEGR--GNSEPGKKKQHICHIENCGKVYGKTSHLRAHLRWHTGERPFVCNWIFCGKRFTRSDELQRHRRTHTGEKR--------------------FECP--------------ECSKRFMRSDHLSKHVKTHQNK-KGGGTALAIVTSGDLDSSVTGVLGSPRIVTVAAISQDSNP------ATPNVSTNIDEF------------------
>Gallus gallus Sp4
FADQKKEE------TMPTEGEKSPEAENNNNNNKKGKTGGSQDSQPSPLALLAATCSKIG--TPGENQATGQQQIIIDPN---------QGLVQLQNQ------PQQLELVTTQLAGNSWQLVAASPSASKDNNVAQQGSSVASSAPSPSSS---------NNGSASPTKTKSGNSSATTPGQFQVIQVQ---NPSGSVQYQVIPQIQTTEGQQIQINPANATGLQDIQGQ--IQLIPAGNNQAILTASNRTASGNIIAQNLANQTVPVQIRPGVSIPLQLQTIPGTQAQVVTTLPINIGG-VTLALPVIN----NMAAGGGSGQVGQS----TEGGVSNGSQLASTPVTS-ASVSSMPDSPSSSS--TSTTTASTSLTSSDTLVSSAETGQYTSTAGSSSEQPTEESQT----TATDSEAQSSSQLQSNGLQNVQDQSGSLQQVQI--VGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQSLQNVQ-LQAVS-PTQVLIRAPTLTPSGQISWQTVQVQNLQSLSNLQVQNAGLPQQLTITPVSSSGG-TTIAQIA-------PVAVAGTPITLNAAQLASVPNLQTVSVANLGAAG--------VQVQGVPVTITSVAGQQQGQDGVKVQQAT-------------------IAPVTVAVGGIANAGIGAVSPDQITQVQLQQAQQASDQEVQPGKRTRRVACSCPNCREGEGR--SSNEPGKKKQHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWVFCGKRFTRSDELQRHRRTHTGEKR--------------------FECP--------------ECSKRFMRSDHLSKHVKTHQNK-KGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNP------ATPNVSTNMEEF------------------
>Tetraodon nigroviridis SP4
-------------------------------------------SQPSPLALLAATCSKIGGQGGAEGAQAGAQQIQVQAGPIQLQAGQLQGQIVVDAAGGQALVPQQLELVPAQFTGNGWQIITTAPTMAKETSNQPVAVTVATTLANDSSP---------GGRKAKEVGPAAQQQ--QQQQQFQIIQVQNLPSAGSGVQYQVIPHLQTADGQQIHISPAQTAPIGALPEQ--VQLIQTQSPSQTQAILQPASQQAILTST-ANQTVPLQIRPAQSFPLQLQTLQGSQAPVMTTVPINIGG-MTLALPVIN----NVAGAG-AVQLIQS--ADGTFSVANGNQLVTTALPG-----PAP--ASSGS----TAVAEGDGVSDGTQMVSVGAEGAQGDGQVQS-----------------GEADSQTQNQANGVQNQPDGTGTVQQVIVGQVGHQLVQQIQLQPQAQSPGQAQ-----GQQQPQHIQTLQLAPGQTLQPIQAFQNPAQVLIRTPTLSPSGQITWQTLQLPSGVSLQGG--LGAAVPQQLTLAPVASGTP---VGSGG-------LVSLSGAPLTLSAAQINPGSGVQTVSIAGLGAAG--------VQVQGVPLTITGLQGQPQGQDGVKVQS----------------------SPVTVAVGNVASGS--SMSPEQLGSVQS-----SSEQDGPPNKRLRRVACSCPNCRDGEGR--NSGDPTKKKQHICHMEGCGKVYGKTSHLRAHLRWHTGERPFVCNWIFCGKRFTRSDELQRHRRTHTGGKPLDTRGR---TPGRAFFSRVLFLFPSSQGKSASSVRSAPSASCAATTSPSTSKPTRTRRAEPRWQSSPPKTWRRTPPKAWARPLTSSPWRLSPATLTPRRPPPLITWRKRRTRTRSLSRRRTLLFTES----------
>Takifugu rubripes SP4
-------------------------------------------SQPSPLALLAATCSKIGGQGGAEVAQAGAQPIQVQAGQIQLQAGQLQGQIVVDTAGGQALVPQQLELVPAQFTGNGWQIITTAPTMAKETSNQPVAVTVATTLANDSSP---------GGRKVKPVGGTNSSP--ATQQQFQIIQVQNLPSAGSGVQYQVIPHLQTADGQQIHISPAQTAPIGALPEQ--VQLIQTQSPSQTQAILQPANQQAILTSS-ANQTVPLQIRPAQSFPLQLQTLQGSQAPVMTTVPINIGG-MTLALPVIN----NVGGAG-AVQLIQA--ADGTLSVANGNQLVTTAVPG-----PAPGTASSGS----TAVADGDSASDGTQMVSVGTEGAQADAQVQS-----------------SEADSQTQNQANGLQSQTDATGTVQQVIVGQVGHQFVQQIQLQPQAQSPGQVQ-----GQQQPQHIQTLQLAPGQTLQPIQAFQNPAQVLIRTPTLSPSGQLTWQTLQLPSSVSLQSG--LGAAVPQQLTLAPVAGGTP---MGGGG-------LVSLSGAPLTLSAAQINPGSGVQTVSIAGLGAAG--------VQVQGVPLTITGIQGQPQGQDGVKVQS----------------------SPVTVAVGNVASGS--SMSPEQLGSVQS-----SSEQDGPPNKRLRRVACSCPNCRDGEGR--NSGDPTKKKQHICHMEGCGKVYGKTSHLRAHLRWHTGERPFVCNWIFCGKRFTRSDELQRHRRTHTGGEQQPCKGARFFYSGIFFLARILCLCP--REKSASSVRSAQSASCAATTSPSTSRPTRTRRVELRWQSSPLKTWRKTLPKAWARPLTLSPWRLSRVTLTLLRPPPLITWRKRRRTTRSLSRR------------------
>Danio rerio Sp4
MSDQKKEA-------MATDGGKASGGDGGT----KGKTSGSQDAQPSPLALLAATCSKIGG-VGAEGQAAAQQQIIIDPN---------QGLLQLQNP------TQQLELVPAQLTGNGWQIIATSPATATKDSIQQAG-------ANAASS---------EAAAGRKVKAVGSNN--AAQQQFQIIQVQNLPNSSGGIQYQVIPHLQTADGQQIQISPSNPAALSVQPEQ--IQLISTGNNQAILATPQRTGSASIVQN----QTIPLQIRP--SFPLQLQTIQGTQAPMVTTLPINLGG-VTLALPVIN----NVAGAGGSVQLLQS----SDGSISNGNQLITTVTTS------TADSTGSST---STTTATG---SDSVVVTSADG--LSTTSMVSAESPK------------DNEADLT---QSNGLQSTSEQAGQIQQFQI--VGHPVLQQIQIQSPQQQVVQG----SIQIQPGQTLQPVQQ----NLQ-LQAFQNPAQVLIRTPTLTPSGQISWQTVQVQ-----------NAGMPQQLTLAPVASSAGGGTFAQIA-------PLTLGGSPITLSAAQLPAGSGVQTVNIAGLGAAG--------VQVQGVPLTITGVQGQQQGQDGVKVQS----------------------APVTVTVGNISN----AVSPEQMGQVQS-----PSDQEGQPSKRLRRVACSCPNCRDGEGR--NNSDPSKKKQHVCHMEGCGKVYGKTSHLRAHLRWHTGERPFVCNWIFCGKRFTRSDELQRHRRTHTGEKR--------------------FECP--------------ECSKRFMRSDHLSKHIKTHQNK-KGG-AALTIITTDEMEEEVDEVLGSPRIVTVATLSHDSNP------ATPTTSNNLEEEFE----------------
>Homo sapiens SP3
------MTAPEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHG--NGAVAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDEEEAAAAAG---APAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPSAA--------------------TSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSADGQQVQIGFTGS-SDNGGINQES-SQIQIIPGSN--QTLLASGTPSANIQN--LIPQTGQVQ-VQGVAIGGSSFPG-QTQVVANVPLGLPG-NITFVPINSVDLDSLGLSGSSQTMTAGINADG--HLINTGQAMDSSDNSERTG--ERVSPDINETNTDTDLFVPTSSS-SQLPVTIDSTGILQQNTNSLTTS------------SGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQ--LNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQ-IQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSP-------------------ADIRIKEEEPDPEEWQ-------------------------LSGDST-----LNTNDLTHLRVQVVDEEG----DQQHQEGKRLRRVACTCPNCKEGGG---RGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKK--------------------FVCP--------------ECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAA--RDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME
>Mus musculus Sp3
------MTAPEKPVKQEEMAALDVD---GGGGGGGHGEYLQQQQQQQQQHGNGAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDDEEAAVAAAAGVPAAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPGAA--------------------TSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQSTDAQQVQIGFTGS-SDNGGINQEN-SQIQIIPGSN--QTLLASGTPPANIQN--LIPQTGQVQ-VQGVAIGGSSFPG-QTQVVANVPLGLPG-NITFVPINSVDLDSLGLSGSSQTMTAGINADG--HLINTGQAMDSSDNSERTG--ERVSPDVNETNADTDLFVPTSSS-SQLPVTIDSTGILQQNTNSLTTT------------SGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQDSQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQ--LNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQ-IQNTAAQQITLTPVQTLTLGQVAAGGALTSTPVSLSTGQLPNLQTVTVNSIDSTGIQLHPGENADSP-------------------ADIRIKEEEPDPEEWQ-------------------------LSGDST-----LNTNDLTHLRVQVVDEEG----DQQHQEGKRLRRVACTCPNCKEGGG---RGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKK--------------------FVCP--------------ECSKRFMRSDHLAKHIKTHQNKKVIHSSSTVLASVEAG--RDDALITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETME
>Rattus norvegicus Sp3
--------------------------------------------------------------------------------------------------AAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPGAA--------------------TSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQSTDAQQVQIGFTGS-SDNGGINQES-SQIQIIPGSN--QTLLASGTPPANIQN--LIPQTGQVQ-VQGVAIGGSSFPG-QTQVVANVPLGLPG-NITFVPINSVDLDSLGLSGSSQTMTAGINADG--HLINTGQAMDSSDNSERTG--ERVSPDVNETNADTDLFVPTSSS-SQLPVTIDSTGILQQNTNSLTTT------------SGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQDSQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQ--LNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQ-IQNTAAQQITLTPVQTLTLGQVAAGGALTSTPVSLSTGQLPNLQTVTVNSIDSTGIQLHPGENADSP-------------------ADIRIKEEEPD-RKSQ-------------------------LSGDST-----LNTNDLTHLRVQVVDEEG----DQQHQEGKRLRRVACTCPNCKEGGG---RGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKK--------------------FVCP--------------ECSKRFMRSDHLAKHIKTHQNKKVIHSSSTVLASVEAG--RDDALITAGGTTLILANIQQGSVSGIGTVNASATSNQDILTNTEIPLQLVTVSGNETME
>Xenopus tropicalis Sp3
------LAAPEQPVKREEMAAMEVD---------GQSEYLQQHGDSS---------------------------------SAGDDSD----------QGGGGGQTEDLA-VQISGGPNRWEVLTPAQAALKDEAGNIVQIPGGATV------------------TSSGQYVLPIQTLQNQHLFSVAPGSDTANGTLSNVQYQVIPQLQTSDGQQVQLGFTTS-SDNGGLDQDG-GQIQIIPGNH--SGSLLSSSPNILTQAGQIQHSGGSVQ-IQGVTIGGTSYAG-QTQVVANVPIGLPG-NITFVPINSVDLDSLGLTGSTEAMTAGLTADG--HLIS-GHGMENSENSERTAEHEHISPDGVDTNSDTDLFVPTSSS-SQLPVTIDGTGMLQQNANSLTDSP-----------SGHVQTSDLHGNYIQTSMTDE--SQNIQVSASQTMVQQIHLQDSQ-PTSQAQLVQSIAQQAIQAVQGGTQGLSSQALQNLQLQ--LNPGTFLIQAQTVTPSGQIAWQTFQVQGVQNLQNLQ-IPNSSAQQITLTPVQTLTLGQVAGGG----TPVSLNAGQLPNLQTVTVNSVDAAGIHLHHGDNSDSPTEIETHQTRQHFSSLQLSNFGIRIKEEEPDPDEWQ-------------------------LAGDST-----VNTNDLTHLRVQVVDDEL----DQPNQEGKRLRRVACTCPNCKDGAG---RGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCTWMFCGKRFTRSDELQRHRRTHTGEKK--------------------FVCP--------------ECSKRFMRSDHLAKHIKTH--------------------------------------------------------------------------------
>Gallus gallus Sp3
------------------------------------------------------------------------------------------------MQLMNHSQTGDLASVQLAGTPNRWEVLSAAPATIKDEAGNIVQIPGAATV------------------TSSGQYVLPIQSLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQTADGQQVQLGFAAS-SDNSSINQET-GQIQIIPGSN--QTIIASGSPSANIQN--ILSQSGQVQ-VQGVAIGGSSFPG-QAQVVANVPLGLPG-NITFVPINSVDLDSLGLGSGSQTMTAGINADG--HLINTGQAMDSSDNSERTG--EQVSPEITETATDNDLFVPTSSS-SQLPVTIDSSSILEQNANNLTTT------------SGQVHSSDLQGNYIQTSVSDDTQAQNIQVSTAQPIVQHIQLQESQQPTSQAQIVQGIAQQTIHGVQAS-QSISPQALQNLQLQ--LNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQ-IQNAPGQQITLTPVQTLTLGQVAAGGALTSTPVSLSTAQLPNLQTVTVNSIDSAGIQLHQGENAGSP-------------------AGCTTLIQQHQTEHWEEVKP----------EKRIVAKVTDALSGASVDMFNNINTNDLTHLRVQVVDEEG----DQPHQEGKRLRRVACTCPNCKEGGGS--RGSNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMFCGKRFTRSDELQRHRRTHTGEKK--------------------FVCP--------------ECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEAT--SDDTLITAGGTTLILANIQQGSVSGIGTVNTSGTSN-----------------------
>Tetraodon nigroviridis Sp3
-------------------------------------------------------------------------------------------------------------ATQLTG-TDRWEVLTPTSE--KDESG-MIQIQSHGVF------------------TSNGQYVLPLQNLQSQPVFVTSETDTSSAASVPNIQYQVIPQIQTADG---QLSFSTSTMEGAALAQDATGQIQILPDGS--QTLGVSSAANILNNNQNLISQTGNVQQIQGVSIGSSTFSN-QGQVVTNVPVGLPG-NITFVPINSVDLDSLGLSG-AQTIATGVTADG--QLIMAGQPVDGSQNLAKTENHLPQTLPGNDSSANPELYVPTSSSQSQLHIPASEAALLTQDASLSSEAT-----------ARSNSSSGLQEGFVQ-----ENQEPNVQASSAQPIIQ---LQQVPIQTANGQVVPSVSP-------------GGQGLQNVQL---INPGTFIIQAQTVTPSGQIQWQTFQVQGVQNLQNLQ-LPTSPPQQITLAPVQALSLG---------SAPVSISTGQIPNLQTVTVNSVAPN-----EGEAEGLG--------------------DIQIK-EEPDSGDWQ-------------------------LSTDST-----LNTSDLSHLRGRLVDED-----DQIGQEGKRLRRVACTCPNCKESGG---RGSSTGKKKQHICHIAGCGKVYGKTSHLRAHLRWHSGERPFVCSWMLCGKRFTRSDELQRHRRTHTGEKK--------------------FVCP--------------ECSKRFMRSDHLAKHIKTHQNKKG---------------------------------------------------------------------------
>Takifugu rubripes Sp3
-------------------------------------------------------------------------------------------------------------STQLTG-TDRWEVLTPTSE--KDESG-MIQIQSQGIF------------------TSNGQYVLPLQNLQSQSVFVTSGTDTSSATSVPNIQYQVIPQIQTADG---QLSFSTSNMEGAGLAQDATGQIHILPDGS--QTLNVSSAANILNN-QNLISQTGNVQQIQGVSIGSSTFNN-QGQVVTNVPVGLPG-NITFVPINSVDLDSLGLSG-AQTIATGVTADG--QLIMANQPVDGSQNLVKTDNHLSQTLPVN-ANANREIYVPTSSSQSQLHIPVSESALLTQDTSLSSVTT-----------AQTNSSSGLQDGFIQ-----ENQDQNIQVSSAQPIIQ---LQQVPIQTTNGQVIQSVTP-------------GGQGLQNVQL---INPGTFIIQAQTVTPSGQIQWQTFQVQGVQNLQNLQ-LPTTPHQQITLAPVQTLSLG---------STPVSIGTGQIPNLQTVTVNSVALN-----EGEADTLG--------------------DIQIK-EEP---DWQ-------------------------LSTDST-----LNTSDLSHLRGRLVDED-----DQIGQEGKRLRRVACTCPNCKESGG---RGSSTGKKKQHICHIAGCGKVYGKTSHLRAHLRWHSGERPFVCSWMLCGKRFTRSDELQRHRRTHTGEKK--------------------FVCP--------------ECSKRFMRSDHLAKHIKTHQNKKGMNSGGSVVASMESTGSSDSIIATAGGTTLILTNIQQGSSNAQDILANAEIPLQLVTT----------VAASEVME
>Homo sapiens SP8
--------------------------------------------------------------------------------------------------------APGLLGEEPRLGSTPLAMLAATCNKIGSPSPSPS--------------------------SLSDSSSSFGKGFHPWKRSSSSSSASCNVVGSSLSSFGVSGASRNGGSSS---AAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTS---SSAAAAAAAAAAAASSSPFANDYS--------------------------------------------DGSHQPVFISKVHTSVDGLQGIY-PRVGMAHPYESWFKPSHPGLGAAGEVGSAGAS-SWWDVG---AGWIDVQNPNSAAALPG----------------------------------------------SLHPAAGGLQTSLHSPLGGYNSDYSGLSHSAFSSGAS---------------------SHLLSPAGQHLMDGFKPVL---------------------------------------------PGSYPDSAPSPLAGAGG--SMLSAGPSAPLG-------------------GSPRSS-------------------------------------------------------------------------ARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKR--------------------FACP--------------VCNKRFMRSDHLSKHVKTH------SGGGGGG--GSAGSGSGGKKG--------SDTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE------------
>Mus musculus Sp8
-------------------------------------------------------------------------------------------------------------------------MLAATCNKIGSPSPSPS--------------------------SLSDSSSSFGKGFHPWKRSSSSSSGSCNVVGSSLSSFGVSGASRNGGSSS---AAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTS---SSAAAAAAAAAAAASSSPFANDYSVFQAPGVSGGSGGGGGGGGGGS-----------------GAHSQDSSHQPVFISKVHTSVDGLQGIY-PRVGMAHPYESWFKPSHPGLGAAADVGSAGAS-SWWDVG---AGWIDVQNPNGAAALPG----------------------------------------------SLHPAAGGLQTSLHSPLGGYNSDYSGLSHSAFSSGAS---------------------SHLLSPAGQHLMDGFKPVL---------------------------------------------PGSYPDSAPSPLAGAGS--SMLSAGPAAQLG-------------------GSPRSS-------------------------------------------------------------------------ARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKR--------------------FACP--------------VCNKRFMRSDHLSKHVKTH------SGGGG-----SAGSG-GGKKG--------SDTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE------------
>Rattus norvegicus Sp8
-------------------------------------------------------------------------------------------------------MATSLLGEEPRLGSTPLAMLAATCNKIGSPSPSPS--------------------------SLSDSSSSFSKGFHPWKRSSSSSSGSCNVVGSSLSSFGVSGASRNGGSSS---AAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTS---SSAAAAAAAAAAAASSSPFANDYSVFQAPGVSGGSGGGGGGGGGGS-----------------GAHSQDSSHQPVFISKVHTSVDGLQGIY-PRVGMAHPYESWFKPSHPGLGAAADVGSAGAS-SWWDVG---AGWIDVQNPNGAAALPG----------------------------------------------SLHPAAGGLQTSLHSPLGGYNSDYSGLSHSAFR-------------------------------------------------------------------------------------------------------------------------------------------GSPRSS-------------------------------------------------------------------------ARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKR--------------------FACP--------------VCNKRFMRSDHLSKHVKTH------SGGGG-----SAGSG-GGKKG--------SDTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE------------
>Xenopus tropicalis Sp8
-------------------------------------------------------------------------------------------------------------------------MLAATCNKIGSPSPSPS--------------------------SLSDSSASFGKGFHPWKRSSSTSS-SCTLASGSLSGFSVGGSSRGGNGSSSAAAAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTSGVSGGGGGGGGSSGSVSAASPFANEYSVFPVSG--GSQEAAAAAAAAAA-----------------AAAAAASHHQPVFLSKVHASVDGLQSIY-PRVGMAHPYESWFKPSHPGEVSAAAAG--GAS-SWWEVG---AGWIDVQSPGAGAALH----------------------------------------------------PGALQGSLHSPLGGYGTDYSAAGLGHFSAGGGGGAGSGGGAAGAGNGGGGGPGSHLLSSGGQHIMDGFKPVIG--------------------------------------------PGSYPDPSSSPLSAGS------MLAPTGPLG-------------------GSPRSS-------------------------------------------------------------------------ARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKR--------------------FACP--------------VCNKRFMRSDHLSKHVKTH------SAGGAGGGAGSTGPGSGSKKG--------SDTDSEHSPSTSPPCHSPDLLHPPD---RNGLE------------
>Tetraodon nigroviridis SP8
--------------------------------------------------------------------------------------------------------------EEPRLGSTPLALLAAACSRIGDPSPSCSP-------------------------ALSE--PGLVKGFHPWKGGSGGTS--------NPGPFGVSSANCRNNGSG--LTNTSSAFSVTTVNSFVGNNYSMYQTSLSS-------------------DNIISDS---------------------------------------------------AHTQRSAFLTKFPPAVEDIAGIY-PRV---PGHQSWFKP-------VGEAGS-GTS-SWWDIG---TSWVDAPSP----------------------------------------------------------------AGLPASLGVCNAEYS----SAFSPGAP----------------------QHLLPATQHLFDGFRQPV---------------------------------------------LAPYADPSAMGAPAAA-----AAATNPVSLP-------------------ASSRSS-------------------------------------------------------------------------SRRYSGRATCDCPNCREAESPGQGGASPRRRGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKR--------------------FECA--------------VCQKRFMRSDHLSKHVRTH------SADGS------EDSGEAG-AR--------GGSDTDHSPPGSPAAPPAAPERLPTTGRQN---------------
>Takifugu rubripes SP8
--------------------------------------------------------------------------------------------------------------EEPRLGSTPLAMLAATCSRIGDPGPSCSP-------------------------ALSDGAPGLVKGFHPWKGGLGGSS--------NLGAFGVPPGNCRNNGTG--LANTNSAFSVTTVNSLMGNNYSMYQTSVSP-------------------DNIIPDS---------------------------------------------------AHSQRSAFLKKFPPSVEDLTGIY-PRV---HGHQSWFKP-------MGDTGN-GTS-AWWDIG---TSWMDAQSP----------------------------------------------------------------TGIPASFGACNTEYS----SPFSPSTS----------------------QHLLPAAQHLFDGFRPSV---------------------------------------------PAPYADTTKIGAP--------VVATNPVPLP-------------------ASSRSS-------------------------------------------------------------------------SRRYSGRATCDCPNCQEAESLGPGGASPQRRGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKR--------------------FECA--------------ICQKRFMRSDHLSKHIRTH------TADGS------EDSGETGHGK--------GSSDTDTSLSGSPASQSA---------------------------
>Homo sapiens Sp2
--------------------------------------------------------------------------------------------------------------MAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCS------------------KIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPGKNSFGILSSKGNILQIQGSQLSASYPGGQLVFAIQNPTMINKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAIITP-----------------SPSSHKPVPIKPAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPTQLLTESPPTP-LSKTNKKARKKSLPASQPP------------------VAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPTPTQVYIRTPSGEVQTVLVQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAPAG-SIISLNAAQLAAAAQAMQTININGVQVQG------------------VPVTITNTG----------------------------GQQQLTVQNVSGNNLTISGLSPTQIQLQMEQA----LAGETQPGEKRRRMACTCPNCKDGEK----RSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKR--------------------FECA--------------QCQKRFMRSDHLTKHYKTHLVTKNL--------------------------------------------------------------------------
>Mus musculus Sp2
-----------------------------------------------------------------------------------------EAAEAREEDVVMSDPQ---MSMAATAAVSPSDYLQPAAATTQAKQPSPLALLAATCS------------------KIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPCKNSFSILSSKGNILQIQGSQLSTSYPGGQFVFAIQNPTLINKGSRSNASIQYQ-VPQIQGNSSQTIQVQPSLTNQIQVIPGTNQAITTP-----------------STSGHKPVPIKPAPVQKSSTTTTPVQSGANVVKLTGGGSNMTLTLPLNNLVNTSDIGGPAQLLTESPPTP-LSKTNKKARKKSLPVSQPS------------------VAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQTTEPTPTQVYIRTPSGEVQTVLVQDSPPATAATTSTVTCNSPALRAPHLSGTSKKHSAAILRKERPLPKIAPAG-SIISLNAAQLAAAAQAMQTININGVQVQG------------------VPVTITNTG----------------------------GQQQLTVQNVSGNNLTISGLSPTQIQLQMEQA----LAGEAQPGEKRRRMACTCPNCKDGEK----RSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKR--------------------FECA--------------QCQKRFMRSDHLTKHYKTHLGTKGL--------------------------------------------------------------------------
>Rattus norvegicus Sp2
-----------------------------------------------------------------------------------------EAAEAREEDVVMSDSQ---MSMAATAAVSPSDYLQPAAAATQAIQPSPLALLAATCS------------------KIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPCKNSFSILSSKGNILQIQGSQLSASYPGGQFVFAIQNPTLINKGSRSNASIQYQ-VPQIQGNSSQTIQVQPNLTNQIQIIPGTNQAIITP-----------------STSGHKPVPIKPAPVQKSNTTTTPVQSGANVVKLTGGGGNMTLTLPLNNLVNTSDIGAPAQLLTESPPTP-LSKTNKKARKKSLPVSQPS------------------VAVAEQVETVLIETTAENIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQTTEPTPTQVYIRTPSGEVQTVLVQDSPPATAATTSTVSCSSPALRAPHLSGSSKKHSAAILRKERPLPKIAPAG-SIISLNAAQLAAAAQAMQTININGVQVQG------------------VPVTITNTG----------------------------GQQQLTVQNVSGNNLTISGLSPTQIQLQMEQA----LAGEAQPGEKRRRMACTCPNCKDGEK----RSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKR--------------------FECA--------------QCQKRFMRSDHLTKHYKTHLGTKGL--------------------------------------------------------------------------
>Gallus gallus Sp2
-----------------------------------------------------------------------------------------SALTADLTPVFLLPPCRLSDSMAATAAVSPSEYLQPAASTAQDSQPSPLALLAATCS------------------KIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLGSGKNSFGILSSKGNLFQIQGSQVGTSYPGGQLVFAIQNPTVISKGTRSSANIQYQAVPQIQAAGGQTIQVQPNLTNQIQIIPGTNQAILTP-----------------SSSSHKPVPIKPAPAQKSG--ASPVQGSSNVVKLTGG-SNVTLTLPMNNLVNTTESSTQAQVIAESP-----SKPGKKTRKKAMSPSQPST-----------------VAVAEQVETVLIETTAENIIQAGNNLLIVQSPGSGQPAVVQQVQVVQPKQESQ-VVQIPQQALRVVQAASATLPTVPQKSSQNIQIQTTESTPTQVYFKTPSGELQTVLLQEAPAVTVAPSS-TSCSSPVSRN---SGTVTSSKKPTARKERPLPKIAPAG-GVISLSAAQLAAAAQAMQTININGVQVQG------------------VPVTITNAG----------------------------GQQQLTVQNVSGNNLTISGLSPTQIQLQMEQA----LSGEMQPGEKRRRMACTCPNCKDGEK----RPGDQGKKKHICHIPECGRTFRKTSLLRAHVRLHTGERPFVCNWVFCGKRFTRSDELQRHARTHTGDKR--------------------FECA--------------QCQKRFMRSDHLTKHYKTHLITKNL--------------------------------------------------------------------------
>Tetraodon nigroviridis Sp2
---------------------------------------------------------------------------------------------------------EQQDSMAATAAVSPSEYLQPSTASSQDAQPSPFGLLAATCS------------------KIGPPAAQAPVTS-APEQPQPRRLLPIKPAPIAPAPPKN-LGFLSAKGNVIQLP-AGLTPTTPGSPIVLTIQQSPARANNP-TPTNIQYQVVPQIQG--AQTIQVMP-QAGQIQLIPGTNHAIITTPMTIPAPT-----AATTSVTPQKTVAIKPSPKPRKA---DTAAA-GNVVQLPGG-----LTLPLN--VATGEVGG-AQVVTETASAPPIPVKGRRGRKKKVAVAAQPPPPTPPPPPPPPPPPQPASPSSGPMETIVIEAG-DNIIQAGNNLLIVQSPG--QPAVVQQVQVVQPKPDSQ-VVQIPQQALKVVQAASATLPPVPQKQALPQSLQVAQTEPSPTQVSLS----LSFSLSLFLFTPPHRVSSRVPNVP---------LIFISLRLFSKQHRGSGRRFSSR----TPSPRRCLLAAQAVQTISINGVHVVG------------------LPVTITNTGRNPTWCLT--------------------GQQHLTVQTMQGGGLQLAATAGQP-TLQVDQT--LTLELPSQPGEKKRRMACTCPNCKDADK----RPGEVGKRKHICHVPGCEKTFRKTSLLRAHVRLHTGERPFVCSWVFCGKRFTRSDELQRHARTHTGDKR--------------------FECS--------------QCQKRFMRSDHLTKHYKTHINTKNL--------------------------------------------------------------------------
>Danio rerio Sp2
---------------------------------------------MDCFAEFLCVDIGWNSAWTLPGAQLPASLPADANEHQPTGISSLTNIGQREIRGVLEYCLYQKDSMATTVAVSPSEYLQPSTTTSQDSQPSPLALLAATCS------------------KIGPPAAQAPVST-PPSQPTTRRLHPIKPAPIAPAPPKN-LGFLSAKGNIIQLP-AGLG-SSGASPIVFTFQ-SPSRPAGT-STANFQYQVIPQFQG--SQTIQMMP-QGGQIQIIPGTNQAIITSPVTVQAATPTAPPLAPAPVPQHKTVAIKPSTQKRRQ---NNASVNANIVRLPSG-----LTLPLN--VTTGDVGG-AQVLTETAAAP---VKPKRGRKRQVAIAAPAPAPQPASPPP----------VAEQVEALLIETTADNIIQAGNNLLIVQNPGGSQPAVVQQVQLLQQKSDQQ-VVQIPPQALKVVQAASATLPPVPQRQTVTPSVQVSPPEPTQVLIKTASGEWQAVQIQETTVTTPTTPTS-TPTPA---------VVTKKVQTGTRKERTLPKIAPAGGGLITLNAAQLASAAQAVQTININGVQVQG------------------VPVTITNAG----------------------------GQQHLTVQTVPSAGLQLGSVQTQTQTMQIEQTQTLALELQTQPGEKKRRMACTCPNCKDAEK----KPGEVGKRKHICHIAGCEKTFRKTSLLRAHVRLHTGERPFVCNWVFCGKRFTRSDELQRHARTHTGDKR--------------------FECN--------------KCQKRFMRSDHLTKHYKTHINTKSL--------------------------------------------------------------------------
>Strongylocentrotus(XP_793203)
---------------------------------------------------------------------------------------MGTPETNVIRSVLMWCPDRAIDLEPSRKGRPPLAMLAATCDRVAEGSPESF------------------------------PDPPKAKGFHPFKRTTPTMSG--LTAEHAASRFAHMAAPGSMLGAS---LPYPLAPSSSLTSPFSGELFFSRKTEPRIP-----------------IATETAKS----------------------------------------------------NTSPYGHKTGFSSETEHLAGILPPHLCGHSAYESWLKAATSASMLSRENGVHGFSPAFWSLPGAQASLLDLHSS---------------------------------------------------------------AGTLPSHFGKMPTCSSASDCSALALSHSVLP------------------YPPLTTTNPHLFSPSQLFP---------------------------------------------PSSYNSFLPPGYDIMSLTEMRSSFFGPAGLG-------------------LSLSRA-------------------------------------------------------------------------GRRYSGRATCDCPNCQENERLAAAGQPLRKKNVHSCHIPGCGKIYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKR--------------------FSCP--------------TCNKRFMRSDHLSKHVKTHQNNNNNSGNDNGGNADSKAAGETGKMSPIKKLASVGSSEAESSPSGTEGSPSPVSTGPGPISMSVPQSAALKVASP----
>Strongylocentrotus(XP_784359)
---------------------MAKKSTKKGQSNYIQPSSMSQETQPSPLALLAATCSKIGTPAEGQAGAVNQGQTVTVLGQ------NQGQAVQIPGGFINAANAQQIQQALGLPPGFPLQFTTASTGVAGQQGTAAGGPMYIEVGPGGNIP---------SSSVGGATPTKSINAANILSLNQQSATGGQQIVTNGNVQYNITPQYQIDSEGNLITTHVATPVSVSQAQAQTTQTVVRQAPTTTSQATNVAGSNVAQIALPGAGVQYIQNGQIIQAVAPQPAPTQQRIMLGSQTITLQLAPNAVMSNANSHDQPVVTPVYNIISSTPPQGNQDNSAQTQQLQIQDQLQNAQIISNSGQIQAGNAANSNQATFVQVAGKPGQIILQQPQQAGQVQQIQVSGLQTSNTN---VQTTQIRQQSGKVVASVIPQQTVQQQPQAQVIQIHQPIQGQAGTQISLQQQPGTGYYTIQQPTPQPQQQAQTITLPVNVAGSQGSVQTITLPIQGNQLQGGSITIPQSVLQSIQQINGGQFMQNPIVLKAPQTQVQTVHLQHGGTPVATPQSSSSQVQQQVITTDVSPAISTANNSTIAGLPNYNVHLAPLSPGPGPAG---NTSAVNINTSTAATQQQITQQQQQQISQALVGMKAEKQQQASWQGVIQTEATGGAQGGTVTTISTNGTNYPPTMASYELQIDQSQIPKQEPPKKVRRLACTCPNCKDGDGR----NSEKGKKQHICHIADCGKIYGKTSHLRAHLRWHTGERPFVCDWLFCGKRFTRSDELQRHRRTHTGEKK--------------------FVCK--------------SCGKKFMRSDHLAKHQRTHIRKPGTVSMKGQSGGGDAPLQVDLSQGVDEFDEEMEKVMRDPQHEAMVQDAVQEAVY-----------------------