>Homo sapiens SLC4A2 MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTP-----QGPGRKPRRRPGASPTGETPTIEEGE----EDEDEASEAEGARALTQ-PSPVST---PSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAE----------------AEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKG-STQSGREGREPGPTPR-ARPRAPHKP---------------------------HEVFVELN--ELLLD-KNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSD------------------------EKDFSFPRNISAGSLGSLLGHHH--GQGAESDPHV----------TEPLMGGVPETR-----LEVERERELPPPAPPAGITRSKSKHELKL-----------------------------------LEKIPENAEATVVLVG--------------------------------CVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELL-RSVAHFQRQMLKKREEQGRLLPTGAGLEPKS------------------------AQDKAL-LQMVEA-----------------------AGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLG---------------------------EKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSEVDGGENM-----------------------TWAGARPTLGPGNRSLAGQSG-----------QGKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVK-------------------------EQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTA-ASLAFPFIL-------------------------ILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDE-----------------------YNEMPMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Mus musculus SLC4A2 MSSAPRRPASGADSLHTPEPESLSPGTPGFPEQEE-DELRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTP-----QGPGRKPRRRPGASPTGETPTIEEGE----EDEEEASEAEGFRAPPQQPSPATT---PSAVQFFLQEDEGAERKPERTSPSPPTQTPHQEAAPRASKGAQTGTLVEE--------------------MVAVASGTAGGDDGGAAGRPLTKAQPGHRSYNLQERRRIGSMTGVEQALLPRVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKG-STQAAREGREPGPTPR-ARPRAPHKP---------------------------HEVFVELN--ELLLD-KNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSD------------------------EKEFSFPRNISAGSLGSLLGHHH--AQGTESDPHV----------TEPLIGGVPETR-----LEVDRERELPPPAPPAGITRSKSKHELKL-----------------------------------LEKIPENAEATVVLVG--------------------------------CVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELL-RSVAHFQRQMLKKREEQGRLLPPGAGLEPKS------------------------AQDKAL-LQMVEV-----------------------AGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLG---------------------------EKTKDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNELEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPLHGCSGSNDSEAGSSSSS-----------------------NMTWATTILVPDNSSASGQSG-----------QEKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPDKRGWVINPLGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVK-------------------------EQRVTGLLVALLVGLSMVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTMRMHLFTALQLLCLALLWAVMSTA-ASLAFPFIL-------------------------ILTVPLRMVVLTRIFTEREMKCLDANEAEPVFDECEGVDE-----------------------YNEMPMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Rattus norvegicus SLC4A2 MSSAPRRPASGADSLHTPEPESLSPGTPGFPEQEEEDELRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTP-----QGPGRKPRRRPGASPTGETPTIEEGE----EDEDEVGEAEGFRAPPQQPSPASS---PSAVQFFLQEDEGTDRKAERTSPSPPTQTPHQEAAPRASKGAQTGTLVEE--------------------MVAVASGTAGGDDGGAAGRPLTKAQPGHRSYNLQERRRIGSMTGVEQALLPRVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKG-STQAAREGREPGPTPR-ARPRAPHKP---------------------------HEVFVELN--ELQLD-KNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSD------------------------EKEFSFPRNISAGSLGSLLGHHH--AQGTESDPHV----------TEPLIGGVPETR-----LEVDRERELPPPAPPAGITRSKSKHELKL-----------------------------------LEKIPENAEATVVLVG--------------------------------CVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELL-RSVAHFQRQMLKKREEQGRLLPPGAGLEPKS------------------------AQDKAL-LQMVEV-----------------------AGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLG---------------------------EKTQDLIGVSELIMSTALQGVIFCLLGAQPLLVIGFSGPLLVFEEAFFSFCKSNQLEYLVGRVWIGFWLVLLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPLHGCSVSNDSEADSSSN------------------------NMTWAATTLAPDNSSASGQ--------------ERPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPDKRGWVINPLGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVK-------------------------EQRVTGLLVALLVGLSMVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTMRMHLFTALQLLCLALLWAVMSTA-ASLAFPFIL-------------------------ILTVPLRMVVLTRIFTEREMKCLDANEAEPVFDECEGVDE-----------------------YNEMPMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Canis familiaris SLC4A2 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FVELN--ELLLD-RNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHRR------------------------------VALPR----------------------SDPSC----------HHWLLG------------------------------------------------------------------------------------------C--------------------------------CVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELL-RSVAHFQRQMLKKREEQGRLLPPGAGLEPKS------------------------AQDK---------------------------------GAVEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLG---------------------------EKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNNLEYLVGRVWIGFWLVLLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPLHGCSVSNGSEAHSGDND-----------------------TWHGAGATLGPGNGSSPGPVG-----------QGRPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRVRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGENSSFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVK-------------------------EQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTA-ASLAFPFIL-------------------------ILTVPLRMVVLTRIFTEREMKCV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Tetraodon nigroviridis SLC4A2 ---------------------SLLHGTARRDEEEDGDLNKALGVHRFQQILSPASTVPDEQLHN-YHEEDIEYHRHSSHNIHRPLSKLPS-EGRRKKS-------SKKRRKNKDLKSKLVALSSPVEEVE----DEEE--EEEEEVTDAPSSPSEAER---PRDVEFFLSDDDCVVRR--GGESVHSAREQDFASPSVEGDASSTDKSTSPEA----------------SSFTPQLVPPEHPPLTRVSSR----------SYDLQERRRTGNMTGAEQAKYQQIPTDETEAQTLASADLDGIKSHRFEDVPGVRRHLVRKSTKGQIVHIGKDHKEPTTRTR-KQDRTPHEPLPVILYRSASQPEGVLLDVGSGHMTQFREVFVELN--ELTMD-KNQELQWKETARWIKFEEDVEEETDRWGKPHVASLSFRSLLELRKTISHGAVLLDLDQKTLPGIAHQVVEQMIISDQIKAEDRANVLRALLLKHSHPSDEK----------------------EHSSHFPRNISAASLGSLITHHHNANHAHQPEPSV----------TDPLMGSVHATRETDTHIDMEKNDVQKEPTAVSGMHRSKSKHELKL-----------------------------------LEKIPENAEATVVLVGQWSPVILSGSTSNNYPFLTCLCSAHRVPPPPGCVDFLEQPTMAFVRLQEAVELESVLEVPVPVRFLFVLLGPPTSSMDYHQIGRSISTLMSDKRFHEAAYLADDRHDLLNAINSFLDCSIVLPPSEVGGDELL-RSVARFQREMLRKREELEVKLSA---KEPKS------------------------LKDK----EALLT-----------------------PLKKSDDPLERTRRPFGGLIRDVRRRYPKYLSDFKDALNSQCMAAVIFIYFAALSPAITFGGLLGGKQEFGYCRLLILQTVAQGVFFFFLLGEKTDGLIGVSELIVSTAVQGVIFCLLGAQPLLIVGFSGPLLVFEEAFYSFCKTNNMEYLTGRVWIGFWLIIIVTLMVAFEGSFLVRFVSRFTQEIFSFLISLIFICETFIKLGRIFKEHPLKRCSLDNSTGG-----------------------------NVTVENATSVPVNSTQPGA--------------EVTLGEPNTALLSLVLMAGTFFIAFYLRKFKNSAFFPGRLRRVIGDFGVPIAILIMVLVAYNLSDTFIQKLSVPKGFSVTSPSKRGWLINPLGSDGKFPVWMMFACCLPALLVFILIFMETQITTLIVSKKERMLVKGSGFHLDLLLIVVLGGTSAVFGLPWMAAATVRSVTHVNALTVMSKAVAPGDKPRIQEVK-------------------------EQRVTGLLVSILVGLSIVIGDLLRQIPLAVLFGIFLYMGVMSLNGIQLTERMMLLLMPPKYHPDHTYVRKVRTLRMHMFTCIQLVCLAVLWSVMSTQ-ASLAFPFIL-------------------------ILTVPVKTFLLPRIFTAREMASLDADDAEPKFDERECQDE-----------------------YSEMHMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Takifugu rubripes SLC4A2 ---------------------SSLHGTARRDEEDDGDLNKALGVQRFQQILSPAAAVPDEQLHN-YHEEDIEYHRHSSHHIHRPLSKLPS-EGRRKKG-------SKKRRKDKHHKSSHAAPSSPYTAYV----RPVG--NKTHFFSEQTFTPS---------SLQFFLSDDDRVVKH--GRGSGHSAREQDIASQSGEGDASSTDKSTSPEA----------------SSSAPQLVPAEHPPLTRVSSR----------SYDLQERRRTGNMTGAEQAKYQRIPTDETEAQTLASADLDGIKSHRFEDVPGVRRHLVRKSTKGQIVHIGKDHKEPTTRAR-KQDRTPHEPLPVILYRSASRPEGFLLDLGSSHMAQYKEVFVELN--ELTMD-KNQELQWKETARWIKFEEDVEEETDRWGKPHVASLSFRSLLELRKTISHGAVLLDLDQKTLPGIAHQVVEQMIISDQIKAEDRANVLRALLLKHSHPSDEK----------------------EHNSHFPRNISAASLGSLVTHHHNANHAHQPEPSV----------TDPLMGGGHAVGETDIHIDVEKNDVQKEPAVVSGMHRSKSKHELKL-----------------------------------LEKIPENAEATVVLVGQLSLVITSGIISNNY-FTACLC------PPPGCVDFLEQPTMAFVRLQEAVELESVLEVPVPVRFLFVLLGPPNSSMDYHQIGRSISTLMSDKRFHEAAYLADDRHDLLNAINSFLDCSIVLPPSEVGGDELL-RSVARFQREMLRKREELEVKLLA---KEPKS------------------------LKDK----EALLT-----------------------PLKKSDDPLERTRRPFGGLVRDVRRRYPKYLSDFKDALNSQCMAAVIFIYFAALSPAITFGGLLGETHTWRTG-VGLLQAVEG---VSLFLGEKTDGLIGVSELIVSTAVQGVIFCLLGAQPLLIVGFSGPLLVFEEAFYSFCKANNMEYLTGRVWIGFWLIIIVTLTVAFEGSFLVRFVSRFTQEIFSFLISLIFICETFIKLGRIFKEHPLKRCSVDNGTDG-----------------------------NVTVENVTSLLNNDTQPAA--------------VTTLGEPNTALLSLVLMAGTFFIAFYLRKFKNSAFFPGRLRRVIGDFGVPIAILIMVLVAYNLSDTFIQKLSVPRGFSVTTPAKRGWLIHPLGSDGNFPIWMMFACCLPALLVFILIFMETQITTLIVSKKERMLVKGSGFHLDLLLIVVLGGTSAVFGLPWMAAATVRSVTHVNALTVMSKAVAPGDKPRIQEVK-------------------------EQRVTGLLVSILVGLSIVIGDLLRQIPLAVLFGIFLYMGVMSLNGIQLTERMMLLLMPPKYHPDHSYVRKVRTLRMHMFTCIQVVCLAVLWAVMSTQ-ASLAFPFVL-------------------------ILTVPVKMFLLPRIFTAREMACLDADDAEPKFDERECQDE-----------------------YSEMRMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Danio rerio SLC4A2 -------------------------------------------------------------------------HRHTSLHIHHPLSKHLP-DGRRKKP-------GRKRKDSGRRRSSSMGAAPPIDEDD----EDEE--ADEDSCSQQDREGNVTTT---PTRLQFFVSEDDPKKNA--KTVNHVPFKTTHQHQHPRGCDGSLVSVHTKHFQ----------------MHVLCVLSSVSSPDGSCKTGR----------SYDLQERRRTGNMTGATLSHYQQMPTDESEAKTLATVDLDGIKSHRFEDVPGVRRHLVKKSAKGQVVHIGKDYKEFSSRIRTKLDRTPHE------------------------------VFVELN--ELLMD-KNQEMHWKETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRKTISHGAVLLDLDQKTLPGIAHQVVEQMIISDQIRAHDRANVLRALLLKHSHPSDGK----------------------EH-SLFNRNISATSLGSLISHYHSTNHIGAPELPA----------TDPLIGGLRNFESRSSVDYVEKN--EKDSPQFFGLHKTKSKHELKL-----------------------------------LEKIPEDAEATVVLVG--------------------------------CVDFLDQPTMAFVRLKEAVLLESVLEVPIPVRFLFVLLGPPSANIDYHQIGRSISTLMSDKHFHEAAYLADGRQDLLTAINSFLDCSIVLPPSEVGGDELL-HSIARFQKEMLHKRHEQEVKLQA---KEPKS------------------------PDDIVLMLSALQP-----------------------PLKPEDDPLRRTGRLFGGVIRDVRRRYPKYISDFKDALSPQCMATVIFIYFAALSPAVTFGGLLG---------------------------EKTDGLIGVSELIISTAVQGMLFCLLGAQPLLIVGFSGPLLVFEEAFYSFCKSNDLEYLTGRMWIGMWLIIIVLLTVAFEGSFLVRFVSRFTQEIFSILISLIFIYETFFKLGKIFMDHPLRSCSGPEENAT-----------------------------SLSTG-----SNDSRSTGA--------------SQTLNQPNTALLSLVLTSGTFFIAYYLRKFKNSAFFPGRLRRAIGDFGVPIAISTMVLLDYSIKDTYTQKLNVPDGFSVTSPDKRGWFIHPLGSDGQFPIWMMGACILPALLVYILIFMETQITTLIVSKKERMLVKGSGFHLDLLIIVVSGGIAALFGLPWLTGATVRSVTHANSLTVMSKAVAPGDKPRIQEVK-------------------------EQRVTGFLVALLVGLSIVIGDLLRQVPIAVLFGIFLYMGVMSLNGIQLTERMMLLFMPPKYHPDHTYVRKVRTLRMHLFTCLQLVCLAVLWIVMSTA-ASLAFPFVL-------------------------VLTVPFRRFLLSRIFSHREIQCLDADDAEPTLDDKDGQDE-----------------------YTEMQMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Homo sapiens SLC4A3 MANGVIPPPGGASPLPQVRVPLEEPPLSPDVEEEDDDLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEE-EEEEEGESEAEPVEPPHSGTPQKAKFSIGSDE--DDSPGLPGRAAVTKPLPSVGPHT---DKSPQHSSRPCSELRDGDGTTDLALSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRP---------------------------HEVFVELN--ELMLD-RSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPND-D----------------------KDSGFFPRNPSSSSMNSVLGNHH---PTPSHGPDG----------AVPTMADDLGEP-APLWPHDPDAKE-KPLH--MPGGDGHRGKSLKL-----------------------------------LEKIPEDAEATVVLVG--------------------------------CVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLL-RSVAAFQRELLRKRREREQTKVEMTTRGGYT------------------------APGKELSLELGGS-----------------------EATPEDDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLL---------------------------GEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHPLLPFYPPEGALEGSLDA-------------------------------GLEPNGSALPPTEG-----------PPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVR-------------------------EQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTA-ASLAFPFLL-------------------------LLTVPLRHCLLPRLFQDRELQALDSEDAEPNFDE-DGQDE-----------------------YNELHMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Mus musculus SLC4A3 MANGVIPPPGGASPLPQVRVPLEEPPLGPDVEEEDDDLGKTLAVSRFGDLISKTPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRPPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGAEEEEEE-EEEEEGESEAEPVEPLPPGPPQKAKFSIGSDE--DDSPGLPVKAPCAKALPSVGLQS---DQSPQRSG---------------------------SSPSPRARASRISTEKSRPWSPSASYDLRERLCPGSALGNPG-PEQRVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRIQGGRGSPSGLAPILRRKKKKKKLDRRP---------------------------HEVFVELN--ELMLD-RSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAQGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPND-D----------------------KDSGFFPRNPSSSSVNSVLGNHH---PTPSHGPDG----------AVPTMADDQGEP-APLWPHDPDAKE-KPLH--MPGGDGHRGKSLKL-----------------------------------LEKIPEDAEATVVLVG--------------------------------CVPFLEQPAAAFVRLSEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLGAISEFLDGSIVIPPSEVEGRDLL-RSVAAFQRELLRKRREREQTKVEMTTRGGYA------------------------APGKELSLEMGGS-----------------------EATSEDDPLQRTGSVFGGLVRDVKRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLL---------------------------GEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFHKLYKVFTEHPLLPFYPPDEALET-----------------------------------GLELNSSALPPTEG-----------PPGPRNQPNTALLSLILMLGTFLIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPHKRTWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVR-------------------------EQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLIFMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTA-ASLAFPFLL-------------------------LLTVPLRRCLLPRLFQDRELQALDSEDAEPNFDE-DGQDE-----------------------YNELHMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Rattus norvegicus SLC4A1 MANGVIPPPGGASPLPQVRVPLEEPPLGPDVEEEDDDLGKTLAVSRFGDLISKTPAWDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARHARRKRKKEKTSAPPSEGTPPIQEEGGAGAEEEEEE-EEEEEGESEAEPVEPPPPGPPQKAKFSIGSDE--DDSPGLSIKAPCAKALPSVGLPS---DQSPQRSG---------------------------SSPSPRARASRISTEKSRPWSPSASYDLRERLCPGSALGNPG-PEQRVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRIQGGRGSPSGLAPILRRKKKKKKLDRRP---------------------------HEVFVELN--ELMLD-RSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAQGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPND-D----------------------KDSGFFPRNPSSSSVNSVLGNHH---PTPSHGPDG----------AVPTMADDLGEP-APLWPHDPDAKE-KPLH--MPGGDGHRGKSLKL-----------------------------------LEKIPEDAEATVVLVG--------------------------------SVPFLEQPAAAFVRLSEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLGAISEFLDGSIVIPPSEVEGRDLL-RSVAAFQRELLRKRREREQTKVEMTTRGGYV------------------------APGKELSLEMGGS-----------------------EATSEDDPLQRTGSVFGGLVRDVKRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLL---------------------------GEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFHKLYKVFTEHPLLPFYPPEEALEP-----------------------------------GLELNSSALPPTEG-----------PPGPRNQPNTALLSLILMLGTFLIAFFLRKFRNSRFLGGKARRVIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPHKRTWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVR-------------------------EQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLIFMPAKHHPEQPYVTKVKTWRMHLFTFIQLGCIALLWVVKSTV-ASLAFPFLL-------------------------LLTVPLRRCLLPRLFQDRELQALDSEDAEPNFDE-DGQDE-----------------------YNELHMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Canis familiaris SLC4A3 MANGAIPPPGGASPLPQVRVPLEEPPLSPDLEE-DDDLGKTLAVSRFGDLISKPPARDPEKPSRSYSERDFEFHRHTSHHTHHPLSARLPPPHKLRRLPPTSARQTRRKRKKERTSAPPSEGTPPIQEEGGAGVEEEEEDDEEEEEGESEAEPAEPPPSGSPQKAKFSIGSDE--EDSPGLSGRAACAKPPASGGPGS---DKSAPPAVSP------------------RLPWCLLSSSSPRARVPRVAGEKSRPWSPSASYDLRERLCPGSALGSPGGPEQQVPTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPGGLAPVLRRKKKKKQLDRRP---------------------------HEVFVELN--ELTLD-RSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPND-D----------------------KDSGFFPRNPSSSSVNSVLGNHH---PTPSHGPDG----------AVPTMSDDVGEP-APLWPHDPDAKE-KPLH--MPGGDGHRGKSLKL-----------------------------------LEKIPEDAEATVVLVG--------------------------------CVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLL-RSVAAFQRELLRKRREREQTKVELTTQGSYV------------------------APGKELSVELGGS-----------------------EATPEDDPLLRTGSVFGGLVRDVKRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLL---------------------------GEKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRSQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFHKLYKVFTEHPLLPFYPPEGALEA-----------------------------------GLELNGSALPPTEG-----------PPGPRNQPNTALLSLILMLGTFLIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPHKRTWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVR-------------------------EQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLSCIALLWVVKSTA-ASLAFPFLL-------------------------LLTVPLRRCLLPRLFQDRELQALDSEDAEPNFDE-DGQDE-----------------------YNELHMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Takifugu rubripes SLC4A3 -------------------------------EEEEENLEKTLSVERFGDIISDSTSSSSGRMGRNYTEKDFEYHRHSFHHTHHPLSTHLPLPQRLRKRVHSMDRRRKKKRKKKKTSLPPSDVTPTIHEVD----EEE-AQSDTDGQGVA-ATPTEPPD----LQPQFSLGSQEDLEEPLPLTSFHVENEHLSTGCGQLKEDDAVLDLKKIHLQ---------LSFFTSIPPPSDPSPSSTTHSCFRRRPVHHRMAGAQRSNYDLRERICIGSMTALETAVYQQVPTDEAEAQMLASADLDDMKSHRFEDNPGVRRHLVKKSSRCQISRASNS-STPLSSLKKKKRAADKKT---------------------------HELFVELN--ELIVE-KDHEMRWKERARWIKFEEDVEEETDRWGKPHVASLSFRSLLELRRTITHGAILLDLEQNSLPGIAHLVVETMIISDQIRAEDRPSVLRALLLKHSHPSD-L----------------------KHR--FHRHQSSASLHGSFNHNH---VQDTN---------------LPLVTEEHVHI-TPLGPAFCCLSK-KSLHPLPPESNPAAARSMKL-----------------------------------LAKIPKDAEAVIVLVG--------------------------------CVEFLEQPAMAFVRLNEAVLLESVLEIPVPVRFLFVLLGPSQSNVDYHEIGRSFSTLMSDKSFHEVAYFADDRQDLLNGINEFLDYSIVIPPSEVEGKDLL-KTVADFQKQMLRKRKERELKKHQS--VLGIE------------------------LNNKEISPCEEEE-----------------------EGDQEVDPLKRSGIIFGGLIHDIRRRYPHYVSDLKDALDTQCIAAVIFIYFAALSPTITFGGLLE--------------------------GEKTEGMMGVTELIVSTATLGVIFSLLAGQPLLIIGFSGPLLVFEEAYFKFCQAYNYEYLTGRVWIGFWLIFIVLVIVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFSKLVKVFKEHPLMSVYPSDATTAN-----------------------------------GFHDDHLVFN---------------------QPNTALLSLVLMMGTFFLAFFLRKLRNSRFLGGKARRIIGDFGIPISILVFVMMDCSIPDTYTQKLNVPSGFSVTSPDKRGWFISPFGDKQPFPTWMMGASVVPALLVFILIFMETQITSLIVSKKERRLVKGSGFHLDLLLIVILGAFCPLFGLPWLTAATVRSVTHVNALTVMSKATAPGEKPKIQEVK-------------------------EQRLTGLLVAVLVGMSIVMTDVLRLIPLAVLFGIFLYMGVTSLTGIQLYERITLMVTPAKHHPDHIYVTKVKTWRMNMFTLTQLGCIITLWVVKSTT-ASLAFPFIL-------------------------IMTVPLRRLILSRIFEERELQALDCDEDSPNFDE-DGRDE-----------------------YNEIHMLV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Tetraodon nigroviridis SLC4A3 -------------------------------KEDEENLEKALSVERFGDIISDSASPSGDRMGRNYTEKDFEYHRHTFHHTHHPLSTHLPLPQRLRKRVHSMDRWRKKKRKKKKTSLPPSDVTPTIHEVD----EEEEAQSDTDGQGVS-ATPTETPD----IQPQFSLGSQEDLEEPPPLTTFHVENEHLLTKKAASMQIQAETHNGKIPLLGQNEEDDGEETACSSVPQQSDPSASNTTHSCFRKRAVHHRLAGTQRSNYDLRERICIGSMTALEMAVYQQVPTDEAEAQMLASADLDDMKSHRFEDNPGVRR-----PSGCQISRASNS-STPLSSLKKKKRAADKKT---------------------------HELFVELNGNRWCLT-KYMNDQWRKCVAFSIHLKHHIKKVERGFFGFFCSSSKKEYFGVLRFLCD----NPKPKQSLLASRSVVLVKIIGCDIVKPEQISNITKHLITKHSHPSD-L----------------------KHR--FHRLQSSTSLHGSFNHNH---VQDTN---------------LPLVTEEHDAV-SVMWLHYWSPYVPKSLHPLPPEGHPAAARSMKL-----------------------------------LAKIPKDAEAVIVLVG--------------------------------CVEFLQQPAMAFVRLNEAVLLESVLEVPVPVRFLFVLLGPSQSNVDYHEIGRSFSTLMSDKSFHEVAYFADNRQDLLNGINEFLDYSIVIPPSDIEGKDLL-KTVVEFQKQMLRKRKERELKKNHSFTAYGAC------------------------KHILEISPCEEEE-----------------------EGDEEVDPLKRSGIIFGGLIHDIRRRYPHYVSDLKDALDTQCIAAVIFIYFAALSPTITFGGLL---------------------------GEKTEGMMGVTELIVSTATLGVIFSLLAGQPLLIIGFSGPLLVFEEAYFKFCQAYNYEYLTGRVWIGFWLIFIVLVIVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFSKLIKVFKEHPLMSVYPNDTTMAY-----------------------------------GFHDDHLALLN--------------------QPNTALLSLVLMIGTFFLAFFLRKLRNSRFLGGKARRIIGDFGIPISILVFVMIDYSVPDTYTQKLNVPAGFSVTSPDKRNWFISPFGDKQPFPTWMMGASVVPALLVFILIFMETQITSLIVSKKERRLVKGSGFHLDLLLIVILGAICPLFGLPWLTAATVRSVTHVNALTVMSKATAPGEKLKIQEVK-------------------------EQRLTGLLVAVLVGMSVVMTRVLRLIPLAVLFGIFLYMGVTSLTGIQLYERITLMVTPAKHHPDRIYVTKVKTWRMNMFTLAQLGCIVALWVVKSTT-ASLAFPFIL-------------------------IMT-PLRRLILSRIFEERELQALDCDEDSPNFDE-DGRDE-----------------------YNEIHMLV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Homo sapiens SLC4A1 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEELQDDYEDMMEENLEQEEYEDPDIPESQMEEPAAHD---------------TEATATDYHTTSHP------GTHKV------------------------------YVELQ--ELVMDEKNQELRWMEAARWVQLEENLGEN-GAWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGELE----------------------ALGGVKPAVLTRSGDPSQPLLPQ----HSSLETQLFCE---------------------------------------QGDGGTEGHSPSGI-----------------------------------LEKIPPDSEATLVLVG--------------------------------RADFLEQPVLGFVRLQEAAEL-EAVELPVPIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQAL-LSLVPVQRELLRRRYQSS-------PAKPDS------------------------SFYKGLDLNGGP-----------------------------DDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLG---------------------------EKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTYNYNVLMVP-------------------------------------------------------------KPQGPLPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVK-------------------------EQRISGLLVAVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTP-ASLALPFVL-------------------------ILTVPLRRVLLPLIFRNVELQCLDADDAKATFDEEEGRDE-----------------------YDEVAMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Mus musculus SLC4A1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGDMRDHEEVLEIPDRDSEEELENIIGQIAYRDLTIPVTEMQDPEALP---------------TEQTATDYVPSSTSTPHP--SSGQV------------------------------YVELQ--ELMMDQRNQELQWVEAAHWIGLEENLRED-GVWGRPHLSYLTFWSLLELQKVFSKGTFLLGLAETSLAGVANHLLDCFIYEDQIRPQDREELLRALLLKRSHAEDLG----------------------NLEGVKPAVLTRSGGASEPLLPH----QPSLETQLYCG---------------------------------------QAEGGSEGPSTSGT-----------------------------------LK-IPPDSETTLVLVG--------------------------------RANFLEKPVLGFVRLKEAVPL-EDLVLPEPVGFLLVLLGPEAPHVDYTQLGRAAATLMTERVFRITASMAHNREELLRSLESFLDCSLVLPPTDAPSEKAL-LNLVPVQKELLRRRYLPS-------PAKPDP------------------------NLYNTLDLNGGKG-----------------------GPGDEDDPLRRTGRIFGGLIRDIRRRYPYYLSDITDALSPQVLAAVIFIYFAALSPAVTFGGLLG---------------------------EKTRNLMGVSELLISTAVQGILFALLGAQPLLVLGFSGPLLVFEEAFFSFCESNNLEYIVGRAWIGFWLILLVMLVVAFEGSFLVQYISRYTQEIFSFLISLIFIYETFSKLIKIFQDYPLQQTYAP-VVMKP-------------------------------------------------------------KPQGPVPNTALFSLVLMAGTFLLAMTLRKFKNSTYFPGKLRRVIGDFGVPISILIMVLVDSFIKGTYTQKLSVPDGLKVSNSSARGWVIHPLGLYRLFPTWMMFASVLPALLVFILIFLESQITTLIVSKPERKMIKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASGPGAAAQIQEVK-------------------------EQRISGLLVSVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPFVKRVKTWRMHLFTGIQIICLAVLWVVKSTP-ASLALPFVL-------------------------ILTVPLRRLILPLIFRELELQCLDGDDAKVTFDEENGLDE-----------------------YDEVPMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Rattus norvegicus SLC4A1(2) -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGDMQDHEKVLEIPDRDSEEELEHVIEQIAYRDLDIPVTEMQESEALP---------------TEQTATDYIPTSTSTSHP--SSSQV------------------------------YVELQ--ELMMDQRNQELQWVEAAHWIGLEENLRED-GVWGRPHLSYLTFWSLLELQKVFSKGTFLLDLAETSLAGVANKLLDSFIYEDQIRPQDRDELLRALLLKRSHAEDLK----------------------DLEGVKPAVLTRSGAPSEPLLPH----QPSLETKLYCA---------------------------------------QAEGGSEEPSPSGI-----------------------------------LK-IPPNSETTLVLVG--------------------------------RASFLVKPVLGFVRLKEAVPL-EDLVLPEPVSFLLVLLGPEAPHIDYTQLGRAAATLMTERVFRVTASLAQSRGELLSSLDSFLDCSLVLPPTEAPSEKAL-LNLVPVQKELLRKRYLPR-------PAKPDP------------------------NLYEALD--GGKE-----------------------GPGDEDDPLRRTGRIFGGLIRDIRRRYPYYLSDITDALSPQVLAAVIFIYFAALSPAVTFGGLLG---------------------------EKTRNLMGVSELLISTAVQGILFALLGAQPLLVLGFSGPLLVFEEAFYSFCESNNLEYIVGRAWIGFWLILLVVLVVAFEGSFLVQYISRYTQEIFSFLISLIFIYETFSKLIKIFQDYPLQESYAP-VVMKP-------------------------------------------------------------KPQGPVPNTALLSLVLMVGTFLLAMMLRKFKNSTYFPGKLRRVIGDFGVPISILIMVLVDTFIKNTYTQKLSVPDGLKVSNSSARGWVIHPLGLYNHFPKWMMFASVLPALLVFILIFLESQITTLIVSKPERKMIKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASGPGAAAQIQEVK-------------------------EQRISGLLVSVLVGLSILMEPILSRIPLAVLFGIFLYMGITSLSGIQLFDRILLLFKPPKYHPDVPFVKRVKTWRMHLFTGIQIICLAVLWVVKSTP-ASLALPFVL-------------------------ILTVPLRRLLLPLIFRELELQCLDGDDAKVTFDEAEGLDE-----------------------YDEVPMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Canis familiaris SLC4A1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDHEEGLEDTLEQEEYEDPYVPMVQVEEPVAYP---------------TEPTATDEDTVTHPDTTPRAGTHEI------------------------------YVELH--ELVMDEKNQELQWMEAAHWVRLEENLGED-GVWGPPHLSYLTFWSLLELQKAFVKGTVLLDLPETSLAGVANQLLDQFIYEEQIRPQDRDLLLRVLLLKHSHAGDLE----------------------ALGGVKPAVLMRSGDPSQPLLPQ----QPSLETQLFCK---------------------------------------QGEGGTE-DSPSRI-----------------------------------LEKIPPDSEATLVLVG--------------------------------RAAFLERPVLGFVRLQMATEL-DAVGLPLPVRFLFVLLGPEAPNTDYTQLGRAVATLMSERVFRTDAYLAQTKEELVRNLDCFLDCSLVLPPCEVPSEQAL-LSLVPVQKELLRRRYLLS-------PAKPDP------------------------HFYKGLDLNGGPG-----------------------GPGESDDPLQRTGLLFGGLVRDIRRRYPLYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLG---------------------------EKTQNQMGVSELLISTAVQGILFSLLGAQPLLVVGFSGPLLVFEEAFFSFCTSNNLEYIVGRVWIGFWLVLLVVLMVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFIKLIKIFQDHPLQRYYDYNMTIIP-------------------------------------------------------------KPQGPLPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVMVDFFIKDTYTQKLSVPRGLSVSNASARGWVIHPLGLYSPFPIWMMFASVLPALLVFILIFLESQITTLIISKPERKMVKGSGFHLDLLLVIGMGGVAALFGMPWLSATTVRSVTHANALTVMGKANIPGAAPQIQEVK-------------------------EQRISGLLVAVLVGVSILMGPILSLIPLAVLFGIFLYMGVTSLSGIQLFDRVLLLFKPPKYHPDVPYVKRVKTWRMHLFTVIQIICLAVLWTMKTFPTTSLTLPFIL-------------------------ILTVPLRRLLLPLIFRKLELQCLDADDAKPTFNEEEGQDE-----------------------YNEVHMPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Tetraodon nigroviridis SLC4A1 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G--------------------------------ALDFLEKPAVVFVRLKESAVLGSALEAPMPVRFVFVLVGPSSADMDYHETGRAMAALLADKVFNQCALQAKTARELTDAVADFMDCSIVIPPTEIQNEAML-TSIINFQKKLLQDRNQASN------PLARRD------------------------SKARRVSISTGP---------------------------PPEDPLSRTGRPFGGMIRDIRRRYQHYRSDITDALNAQVLAAVIFIYFAALSPAITFGGLLA---------------------------DKVENMMGVPELLISTSIQGIIFCFVAAQPVLVIGFSGPLLVFEEAFYAFCKSQEIEYIVGRVWVGVWLVIIVVAIVAFEGSFLVRFISRFTQEIFSILISLIFIYETFAKL-----------------------------------------------------------------------------------------------------------------------GRVRRLIGDFGVPISMFLMIVLDYNIADTYTQKLVVPKGLMVSNPAKRGWLINPFGEHEPFPVWLMFASCVPALLVFILIFLESQITTLIVSKPERKMVKGSGFHFDLLILVGMGGLSAIFGVPWLSAATVRSVTHANALTVMSKGPKP----AIEKVM-------------------------EQRVSGILVALLVGLSILMEPILKMIPVSALFGIFLYMGVTSLNGIQLWDRMLLLLIPKKYHPDEPYVTKVSTGRMHLFTAIQIVCLALLWIVKSSPDLSCSSLCAH-------------------------PHHPSAHAHDRAPVHRSGNEMCKCFPRLSRSRNVCRGRSK-----------------------L------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Homo sapiens SLC4A10 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEPLLPTRNDEEAVVDRGGTRSILKTHFEKEDLEGHR--TLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRE------------------RDSGLEDGRE-----SPSFDTPSQRVQFILGTEDDD------------------------EEHIPHDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTN-----------------------RIPIVRSFADIG-------------------------KKQSEPNSMDKNAGQVVSPQSAPACVENKND-------VSRENSTVDFSK------------------------------VDLHFMKKIPPGAEASNILVG--------------------------------ELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQ-EKRKIP------AVPNG---------------------------------TAAHGEAEP-----------------------HGGHSGPELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLG---------------------------EATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLELLTQYSCNCVEPHNPSNGTLKEWR----------ESNISASDIIWENLTVSECKSLHGEYVGRACGHDHPYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIG-IPSPKLQVPSVFKPTRDD-RGWFVTPLG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIR-------------------------EQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIK-VSRAAIVFPMM--------------------------VLALVFVRKLMDLLFTKRELSWLDDLMPESKKKKLEDA-----------------------EKEEEQSMLAMEDEG-------------------------------TVQLPLEGHYRDDPSVINISDEMSKTALWRN-----------LLITADNSKDKESSFPSK-RTPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Mus musculus SLC4A10 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RNDEEAVVDRGGTRSILKTHFEKEDLEGHR--TLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRE------------------RDSGLEDGRE-----SPSFDTPSQRVQFILGTEDDD------------------------EEHLPHDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTIEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLAN-----------------------RIPIVRSFADIG-------------------------KKQSEPNSMDKNAGQVVSPQSAPACAENKND-------VSRENSTVDFSK------------------------------VDLHFMKKIPPGAEASNILVG--------------------------------ELEFLDRTVVAFVRLSPAVLLQGLAEVPIPSRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQ-EKRKIP------AVPNG---------------------------------TAAHGEAEP-----------------------HGGHSGPELQRTGRIFGGLILDIKRKAPFFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLG---------------------------EATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSETYPINMHNDLELLTQYSCNCMEPHSPSNDTLKEWR----------ESNLSASDIIWGNLTVSECRSLHGEYVGRACGHGHPYVPDVLFWSVILFFSTVTMSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIG-IPSPKLQVPSVFKPTRDD-RGWFVTPLG---PNPWWTIIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIR-------------------------EQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQLFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTVIQMSCLGLLWIIK-VSRAAIVFPMM--------------------------VLALVFVRKLMDFLFTKRELSWLDDLMPESKKKKLEDA-----------------------EKEEEQSMLAMEDEG-------------------------------TVQLPLEGHYRDDPSVINISDEMSKTAMWGN-----------LLVTADNSKEKESRFPSK-SSPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Rattus norvegicus SLC4A10 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RNDEEAVVDRGGTRSILKTHFEKEDLEGHR--TLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRE------------------RDSGLEDGGE-----SPSFDTPSQRVQFILGTEDDD------------------------EEHIPHDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQSQKKLTN-----------------------RIPIVRSFADIG-------------------------KKQSEPNSMDKN-GQVVSPQSAPACAENKND-------VSRENSTVDFSKGLGGQQKGHTSPCGMKQRLDKGPPHQQEREVDLHFMKKIPPGAEASNILVG--------------------------------ELEFLDRTVVAFVRLSPAVLLQGLAEVPIPSRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQ-EKRKTP------SLPNG---------------------------------TAAHGGPEQ-----------------------HGGHSGPELQRTGRIFGGLILDIKRKAPFFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLG---------------------------EATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSESYPINMHNDLELLTQYSCNCMEPHSPSNDTLKEWR----------ESNISASDIIWGNLTVSECRSLHGEYVGRACGHGHPYVPDVLFWSVILFFSTVTMSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIG-IPSPKLQVPSVFKPTRDD-RGWFVTPLG---PNPWWTIIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIR-------------------------EQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQLFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTVIQMSCLGLLWIIK-VSRAAIVFPMM--------------------------VLALVFVRKLMDFLFTKRELSWLDDLMPESKKKKLEDA-----------------------EKEEEQSMLAMEDEG-------------------------------TVQLPLEGHYRDDPSVINISDEMSKTAMWGN-----------LLVTADNSKEKESRFPSKRSSPG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Canis familiaris SLC4A10 ------------------------------------------------------------------------------------------------------------------------------------------------------------QCRTWPAARVSRSHVTLVSWSVQPPPASEVPDPNTKQSECRAGCRTLKTLQRRVLIPEALQDMEIKDQGAQMEPLLPTRNDEEAVVDRGGTRSILKTHFEKEDLEGHR--TLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRE------------------RDSGLEDGRE-----SPSFDTPSQRVQFILGTEDDD------------------------EEHIPHDLFTELDEICWRESEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTN-----------------------RIPIVRSFADIG-------------------------KKQSEPNSMDKN-GQVVSPQSAPACVENKND-------VSRENSTVDFSK------------------------------VDLHFMKKIPPGAEASNILVG--------------------------------ELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQ-EKRKIP------AVPNG---------------------------------TAAHGEAEP-----------------------HGGHSGPELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLG---------------------------EATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLELLTQYSCNCVEPHNPSNDTLKEWK----------ESNISASDIIWENLTVS------------------------------------------------------VRSIVSDFAVFLTILCMVLIDYAIG-IPSPKLQVPSVFKPTRDD-RGWFVTPLG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIR-------------------------EQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTVIQMSCLGLLWIIK-VSRAAIVFPMM--------------------------VLALVFVRKLMDFLFTKRELSWLDDLMPESKKKKLEDA-----------------------EKEEEQSMLAMEDEG-------------------------------TVQLPLEGHYRDDPSVINISDEMSKTALWRN-----------LLMTADNSKDKESSFPSK-SSPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Homo sapiens SLC4A8 ------------------------------------------------------------------------------------------------------------------------------VLPREELQATATSRERRQEGPAWPSPFILLSGVVRRKRKRRRLAEEEDNYIESVVKFRLEHNKCSMFNKNNSNKLRSTPRYRRGDPGYLNFTELGPLKPEQKDQWSQHRPDEEAVVDQGGTSTILNIHYEKEELEGHR--TLYVGVRMPLG-RQSHRHHRTHGQKHRRRG--------------------RGKGASQGEE--GLEALAHDTPSQRVQFILGTEED-------------------------EEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNN-----------------------LIPIVRSFAEVG-------------------------KKQSDPHLMDKHGQTVSPQSVPTTNLEVKNG-------VNCEHSPVDLSK------------------------------VDLHFMKKIPTGAEASNVLVG--------------------------------EVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQ-EKRKMP------GVPNG---------------------------------NVCHIEQEP-----------------------HGGHSGPELQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLG---------------------------EATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWK----------DHNIVTAEVHWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLIG-VPSPKLQVPSVFKPTRDD-RGWIINPIG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIR-------------------------EQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIK-ASPAAIVFPMM--------------------------VLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDA-----------------------KKKAKEEEVIVLAPT--------------------------------VYLGASN-YRT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Mus musculus SLC4A8 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLRPAMPAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHR--TLYVGVRMPLG-RQSHRHHRTHGQKHRRRGG-------------------RGKGASQGEE--GLEALAHDTPSQRVQFILGTEED-------------------------EEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGSVLLDMRASSIEEISDLILDQQELLRDLSDSVRVKVREALLKKHHHQNERRRNN-----------------------LIPIVRSFAEVG-------------------------KKQSDPHSMDRDGQTVSPQS--ATNLEVKNG-------VNCEHSPVDLSK------------------------------VDLHFMKKIPTGAEASNVLVG--------------------------------EVDTLDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQ-EKRKMP------GVPNG---------------------------------NVCHIEPEP-----------------------HGGHSGPELERTGRLFGGLVLDVKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLG---------------------------EATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYALSYLSLRALIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCVLPENPNNHTLQYWK----------DHNILAAEVNWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFATFIVSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVVLDFLIG-VPSPKLQVPNVFKPTRDD-RGWFINPIG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIR-------------------------EQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIK-ASPAAIVFPMM--------------------------VLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDA-----------------------KKKEEEE-AEKMLDIGGDKFPLESRKL-------------------LSSPGKSSSFRCDPSEINISDEMPKTTVWKA-----------LSINSGNTKEKSPFC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Rattus norvegicus SLC4A8 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHR--TLYVGVRMPLG-RQSHRHHRTHGQKHRRRGG-------------------RGKGASQGEE--GLEASAHDTPSQRVQFILGTEED-------------------------EEHVPHELFTELDEICMKEGEEAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGSVLLDMRASSIEEISDLILDQQELLRDLSDSVRVKVREALLKKHHHQNEKKRNN-----------------------LIPIVRSFAEVG-------------------------KKQSDPHSMDRDGQTVSPQSAPATNLEVKNG-------VNCEHSPVDLSK------------------------------ADLHFMKKIPAGAEASNVLVG--------------------------------EVDTLDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQ-EKRKMP------GVPNG---------------------------------NICHVEPEP-----------------------HGGHSGPELERTGR-------------------------LQCLASFLFLYCACMSPVITFGGLLG---------------------------EATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCALPENPNNHTLQYWK----------EHSIPTADVNWANLTVSECQEMHGEFIGSACGHHGPYTPDVLFWSCILFFATFIVSSTLKTFKTSRYFPTRVRSTVSDFAVFLTIFTMVILDFLIG-VPSPKLQVPSVFKPTRDD-RGWFISPIG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLVVAIMLGVCSLMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIR-------------------------EQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIK-ASPAAIVFPMM--------------------------VLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDA-----------------------KKKEEEEEAEKMLDIGGDKFPLESRKL-------------------LSSPGKNNSFRCDPSEINISDEMPKTTVWKA-----------LSINSGNTKEKSPFN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Canis familiaris SLC4A8 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QQRPDEEAVVDQGGTSTILNIHYEKEELEGHR--TLYVGVRMPLG-RQSHRHHRTHGQKHRRRG--------------------RGKGASQGEE--GPEALAHDTPSQRVQFILGTEED-------------------------EEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMRANSIEEISDLILDQQELFSDLNDSMRVKVREALLKKHHHQNEKKRNN-----------------------LIPIVRSFAEVG-------------------------KKQSDPHSMDKNGQTVSPQSVPTTSLEVKNG-------VNYEHSPVDLSK------------------------------VDLHFMKKIPTGAEASNVLVG--------------------------------EVDSLDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQ-EKRKMP------GVPNG---------------------------------NVCHIEPEP-----------------------HGGHSGPELQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLG---------------------------EATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTVPENPSNHTLQYWK----------DHHIVTTEVQWANLTVSECQELHGEFTGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLIG-VPSPKLQVPSVFKPTRDD-RGWIISPIG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIR-------------------------EQRVTGLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIK-ASPAAIVFPMM--------------------------VLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDA-----------------------KKKAKEEEVIVLAPT--------------------------------VHSGAASSYRT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Tetraodon nigroviridis SLC4A8 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPDEEVVVDQGGTSSVLNIHYEKEELEGHR--TLFVGVRMP---RQSHRHHKTHSSRHRKREKRT-----------------GSIVTQQSEE-SVTISSIHDTPSQRVQFILGTEDD-------------------------AEHVAHELFTELDEICVKDGKDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCIINGSVLLDMRATCIEEIADMVLDHQEASSELDDSVRVKVREALLKRHHHQNEKKKN------------------------LIPIVRSITEGT-------------------------RKQSEPHLMG----TATSPQPQPAADLAKNG-------GGQDSTQVDLSK------------------------------VDLHFMKKIPEGAEASNVLVG--------------------------------ELDFLERPIVAFVRLSPAVLLTGLTEVPIPTRFLFILLGPDGKAQQYHEIGRSMATIMTDEIFHDVAYKAKDRSDLLAGIDEFLDQVTVLPPG--------DSLIFVCNVQEKRKMP------GVPNG---------------------------------TVCPVEEEL-----------------------HAEHHGPELQRTGKLFGGLIQDIKRKAPFYLSDFKDGVSLQCVASFLFLYCACMSPVITFGGLLG---------------------------EATEGRISAIESLFGASMTGVAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYDLSYLSLRACIGLWTALLCLILVATDASSLVCYITRFTEEAFAALICLIFIYEALEKLLHLGEVYPFNAHSDLDQLTLAYCRCSEPDSPSNKTLELWR----------DRNVTASAVTWSNLTVKECISLHGQFVGTACGHHGPYTPDVLFWSTILFFSTFFMSTFLKQFKTSRYFPTKVRSTISDFAVFLTIVIMVLLDFIIG-VPSQKLKVPSKFQPTRDD-RGWLINPIG---RNPWWTVLAASIPALLCTILIFMDQQITAVIINRKEHKLLKGCGYHLDLLMVGVMLAVCSIMGLPWFVAATVLSISHVNSLKLESESSAPGEQPRFLGIR-------------------------EQRLTGLVIFLLMGCSVFMTGALQFIPMPVLYGVFLYMGVSSLKGIQFFDRLKLFGMPPKHQPDFIYLRHVPLRKVHLFTVTQLTCLVLLWIIK-TSPAAIVFPMMANLFS----------------FYVLQVLALVFVRKVLDLCFSNRELSYLDDLMPEWKKKNLDDA-----------------------SKKIEEV---MLSEQ-----RENTIEIPMVSS-------------EPAHVQKTHDPR--IEEITYIDE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Takifugu rubripes SLC4A8 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPDEEVVVDQGGTSSAMNIHYEKEELEGHR--TLFVGVRMP---RQSHRHHKPHGSRHRKREKRT-----------------GSIVTQQSEE-SVTITSSHDTPSQRVQFILGTEDD-------------------------AEHVAHELFTELDEICVKDGKDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCIINGSVLLDMRASCIEEIADMVLDHQEASSELDDSVRVKVREALLKRHHHQNEKKKN------------------------LIPIVRSIAEGT-------------------------RKQSEPHLMGGNNRTATSPQPQPVADPAKNG-------GGQDSTQVDLSK------------------------------VDLHFMKKIPEGAEASNVLVG--------------------------------ELDFLERPIVAFVRLSPAVLLTGLTEVPIPTRFLFILLGPDGKAQQYHEIGRSMATIMTDEIFHDVAYKAKDRSDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQAGKRKMP------GVPNG---------------------------------TACPVEEEL-----------------------HAEHHGPELQRTGKLFGGLIQDIKRKAPFYLSDFKDGMSLQCVASFLFLYCACMSPVITFGGLLG---------------------------EATEGRISAIESLFGASMTGVAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYDLSYLSLRACIGLWTALLCLFLVATDASSLVCYITRFTEEAFAALICLIFIYEALEKLCHLGEVYPFNTHSDLDHLTLAYCRCAEPDIPTNKTLELWR----------ERNVTASVVPWSNLTVKECIGLHGQFVGTACGHHGPYTPDVLFWSTILFFSTFFMSTFLKQFKTSRYFPTKVRSTISDFAVFLTIVVMVLLDFVIG-VPSQKLKVPSKFQPTRDD-RGWLINPIG---RNPWWTVLAASIPALLCTILIFMDQQITAVIINRKEHKLLKGCGYHLDLLMVGVMLAVCSIMGLPWFVAATVLSITHVNSLKLESESSAPGEQPRFLGIR-------------------------EQRLTGLVIFLLMGCSVFMTGALQFIPMPVLYGVFLYMGVSSLKGIQFFDRLKLFGMPPKHQPDFIYLRHVPLRKVHLFTVTQLTCLVLLWVIK-TSPAAIVFPMMASLQTHFPRSPSKYEQYQQFFFLCLQVLALVFVRKVLDLCFSNRELSYLDDLMPEWKKKNLDDA-----------------------SKKIEEV---MLSEK-----RENTVEIPMESS-------------KPTHVQKTHDPRSDPSDINISDEMSKTTVWKS-----------LNSNQKDSRPATAKKARP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >Danio rerio SLC4A8 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------MPAENSDQESMLSYQCTCSSSGIPIARDNSSHHAFIIRVIDCVPAGARTVSVPRYPQMTLTPSSPSLDERPGEEAVVDHGGTSSVLNIHYEKEELEGHR--TLFVGVRMPMD-RPSHRHHRPHSSRHRRRSDRM-----------------RAGGSAQDDDNSESTPGAHDTPSQRVRFILGTEED-------------------------EEHVAHELFTELDEICVKEGKDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCIINGTVLLDMKAGSIEEIADLVLEKQETPHELDDSVRMKVREALLKRHHHQNDKKRNN-----------------------LLPMVKTLTEAN-------------------------RRHSETHFMDKTG-LATSPQPPTTSTDIKNG-------ATSEIGQMDLSK------------------------------VDTHFMKKIPTGAEASNVLVG--------------------------------ELDFLERSIVAFVRLSPAVLLTGLTEVPIPTRFLFILLGPDGKAQQYHEIGRSMATIMTDEIFHDVAYKAKDRTDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKCVPSQ-EKRKMP------GVPNG---------------------------------TAVTVEEEL-----------------------HAEHHGPELQRTGRLFGGLILDLKRKAPYYLSDFKDGLTLQCVASFLFLYCACMSPVITFGGLLG---------------------------EATEGQISAIESLLGASMTGVAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYDLSYLSLRTCIGLWTAFLCLLLVATDASSLVCYITRFTEEAFAALICLIFIYEALEKLFYLGELYPINRHSDLDKLTLAYCRCAEPDNPSNKTLEVWN----------QRNITASAVPWTNLTVTECLDLQGQFIGPSCGHHGPYTPDVLFWSSILFFGTFLMSSFLKQFKASRYFPTRVRSMISDFAVFLTIVFMVLIDYIIG-VPSQKLQVPSKFKPTRDD-RGWVMNPIG---RNPWWTVLAALIPALLCTILIFMDQQITAVIINRKEHKLVKGCGYHLDLLMVGVMLAVCSMLGLPWFVAATVLSISHVNSLKLESESSAPGEQPRFLGIQ-------------------------EQRLTGLFIFLLMGCSVFMTGLLQFIPMPVLYGVFLYMGVSSLKGIQLFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLTQLTCLVLLWVIK-HSPAAIVFPMM--------------------------VLALVFIRKLLDFCFSKRELSYLDDLMPENRKKKLDDD-----------------------SKKAEEESQEMLVDESGESDNKDTVQIPMES--------------KPLHSPRTPDPRTDPSDINISDEMSKTTVWKS-----------LNSNNMDTQRASTHKKHPLIYAVPHKSGLRNVSAFSGESVLLPCSCLDPQHRPNSVSWETNSRRASKDALYTDISSVFELYRHKITLFNQTSPGNFSLLLSDLTEEDQGSVRINDRESSEVSHDGHISKEELKNALQDDTVAQKLIEDFKKYGRDYELKLRDYLTRSIPNYPTPVEFHTSEVSHATHMDALDRILDSEGFKADGEDLKFSWWSLKIDEECIKAAEERYLEKVFPNRSQEQRERQEAFLSKFTTSPAFHIHESRYGNFRFVFSLNKMMEAYKEQFCGGRDPVLREYKTVFYKQEIMYAVLVHSPDDDEKFQNYSTIEESRFIDYRNNQIVWRAQAIGDSIQFNLILDEENKTANAERAFGENYYVWDHVCLAFHFRDLLKFPKDALLQNCIPCKKKKSRNKNCKGKMVLI >Homo sapiens SLC4A5 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKVKEEKAGVGKLDHTNHRRRFPDQKECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPDQPQQEL------TGP-GSGASSQDSSMDLISRTRSPAAEQLQDILGEEDE---------------------------APNPTLFTEMDTL-QHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKKPIHR----------------------SLADIGKSVSTTNRSPAR---------------------SPGAGPSLHHSTEDLRMRQSAN-YGRLCHAQ----SRSMNDISLTPNTD-----------------------------QRKNKFMKKIPKDSEASNVLVG--------------------------------EVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKR-KSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMP-----------------------AMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLG---------------------------DATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLLSKKECLSYGGRLLGNSCK----FIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFG-LETPKLHVPSVIKPTRPD-RGWFVAPFG---KNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVR-------------------------EQRVTGIIVFILTGISVFLAPILK------------------------------------------------------------------------------------------------------------ILGLIIVRRLLDFIFSQHDLAWIDNILPEKEKKET-DKKR---------------------KRKKGAHEDCDEEPQFPP-----------------------------PSVIKIPM---ESVQSDPQNG----IHCIA-----------RKRSSSWSYSL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ >Mus musculus SLC4A5 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDTL-QHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSCSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRKHRHQTKKPIHR----------------------SLADIGKSVSTTNRSSAR---------------------SSSAGPTLHRSTEDLRIRQSTS-YGHLCHAQ----SRSMNDISHTPNTD-----------------------------QRKNKFMKKIPKDSEASNVLVG--------------------------------EVDFLDQPFIAFVRLVQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSADKR-KSVFSLAEPGQMNGSVGGGGASAGG-------GGSGGGAGGSGAGGVGSGDEAEMP-----------------------AMHEIGEELIWTGRFFGGLCLDVKRKLPWFPSDFYDGFHLQSISAVLFIYLGCITNAITFGGLLG---------------------------DATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKANGLDYMEFRLWIGLHSAIQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINTDFKPDFITTYKCECVAPDTVNTTTVNASAPLAPNTNTSLYTPLNLTALDWSLLSKKECLSYGGRLLGSSCQ----FVPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRTLVADFSIVFSILLFCGIDACFG-LQTPKLHVPSVIKPTRPD-RGWFVAPFG---KNPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLRKAAGYHLDLFWVGILMALCSFTGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVR-------------------------EQRVTGVMVFILTGISVFLAPILKYIPMPVLYGVFLYMGVASLNGIQFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLALLWILK-STMAAIIFPVM--------------------------ILGLIIVRRLLDLIFSQHDLAWIDNILPEKDKKET-DKKK---------------------KRRKEVHETAEKEVAMEKDL---------------------------PVGVTLSD---SSISGSELDRSITLHFKIS-----------CPASPAFSYSRSPVFMVPQVRIEMESELNLTDDDEEDYG---REVGGETTL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------